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Conserved domains on  [gi|567929780|ref|WP_024032176|]
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MULTISPECIES: cell envelope integrity protein TolA [Pseudoalteromonas]

Protein Classification

cell envelope integrity protein TolA( domain architecture ID 11495137)

cell envelope integrity protein TolA is part of the Tol-Pal system that plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TonB_C super family cl10048
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 213-304 2.62e-24

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


The actual alignment was detected with superfamily member pfam06519:

Pssm-ID: 471968 [Multi-domain]  Cd Length: 94  Bit Score: 94.42  E-value: 2.62e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  213 RQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVCEAALRAVRMADTLPVSKDKD 292
Cdd:pfam06519   3 GSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAVAKTAKIPKPPSQD 82

                          90
                  ....*....|..
gi 567929780  293 VFEQLKNINLTI 304
Cdd:pfam06519  83 VYEKFKNINLDF 94
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 45-306 1.39e-23

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


:

Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 98.76  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   45 DNAVSAVTVDQKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKK 124
Cdd:TIGR02794  35 AEIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  125 AREIEQKERAKAKQAEKQKQEAENAAKAAAD--------------------------KRKAEEEALKKAEAERKKREAEA 178
Cdd:TIGR02794 115 EEKQKQAEEAKAKQAAEAKAKAEAEAERKAKeeaakqaeeeakakaaaeakkkaeeaKKKAEAEAKAKAEAEAKAKAEEA 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  179 KERAKEAERKRQQALQEQMLQEQLAKEQAARSK------------------------IRQQQVVSEVDKYRALIMARIQQ 234
Cdd:TIGR02794 195 KAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERkadeaelgdifglasgsnaekqggARGAAAGSEVDKYAAIIQQAIQQ 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 567929780  235 NLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVCEAALRAVRMADTLPVSKDKDVFEQLKNINLTIKP 306
Cdd:TIGR02794 275 NLYDDPSFRGKTCRLRIRLAPDGTLLSVTKSSGDPALCQAALAAVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
 
Name Accession Description Interval E-value
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 213-304 2.62e-24

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 94.42  E-value: 2.62e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  213 RQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVCEAALRAVRMADTLPVSKDKD 292
Cdd:pfam06519   3 GSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAVAKTAKIPKPPSQD 82

                          90
                  ....*....|..
gi 567929780  293 VFEQLKNINLTI 304
Cdd:pfam06519  83 VYEKFKNINLDF 94
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 45-306 1.39e-23

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 98.76  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   45 DNAVSAVTVDQKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKK 124
Cdd:TIGR02794  35 AEIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  125 AREIEQKERAKAKQAEKQKQEAENAAKAAAD--------------------------KRKAEEEALKKAEAERKKREAEA 178
Cdd:TIGR02794 115 EEKQKQAEEAKAKQAAEAKAKAEAEAERKAKeeaakqaeeeakakaaaeakkkaeeaKKKAEAEAKAKAEAEAKAKAEEA 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  179 KERAKEAERKRQQALQEQMLQEQLAKEQAARSK------------------------IRQQQVVSEVDKYRALIMARIQQ 234
Cdd:TIGR02794 195 KAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERkadeaelgdifglasgsnaekqggARGAAAGSEVDKYAAIIQQAIQQ 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 567929780  235 NLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVCEAALRAVRMADTLPVSKDKDVFEQLKNINLTIKP 306
Cdd:TIGR02794 275 NLYDDPSFRGKTCRLRIRLAPDGTLLSVTKSSGDPALCQAALAAVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 55-307 8.54e-10

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 59.05  E-value: 8.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLE----------RRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKK 124
Cdd:PRK09510 114 QEQKKQAEEAAKQAALKQKQAEEAAAKAAAaakakaeaeaKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAA 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 125 AREIEQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAK 204
Cdd:PRK09510 194 KAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAP 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 205 EQAARSKIRQQQVV------------SEVDKYRALIMARIQQNLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVC 272
Cdd:PRK09510 274 KTGGGAKGNGAQGAgagngkkggasgADIDQYAGQIKSAIQSKFYDASSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALC 353

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 567929780 273 EAALRAVRMAdTLPVSKDKDVFEQLKNINLTIKPE 307
Cdd:PRK09510 354 QAALAAAKTA-KIPKPPSQEVYEKFKNAPLDFKPQ 387
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 37-282 3.12e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 3.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  37 LNSAIPEPDNAVSAVTVDQKQVEQKIAELQKKED---AKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEK 113
Cdd:COG1196  293 LLAELARLEQDIARLEERRRELEERLEELEEELAeleEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 114 EKAQAEAEAKKAREIEQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQAL 193
Cdd:COG1196  373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 194 QEQMLQEQLAKEQAARSKIRQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQ-----CRVNIRLGFNGLVTQVKSLGGD 268
Cdd:COG1196  453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGflegvKAALLLAGLRGLAGAVAVLIGV 532

                        250
                 ....*....|....
gi 567929780 269 KLVCEAALRAVRMA 282
Cdd:COG1196  533 EAAYEAALEAALAA 546
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 161-213 1.17e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 567929780  161 EEALKKA--EAERKKREAEAKERAKEAERKRQQALQEQmlQEQLAKEQAARSKIR 213
Cdd:pfam03154 590 EEALEKAkrEAEQKAREEKEREKEKEKERERERERERE--AERAAKASSSSHEGR 642
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 43-204 1.04e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.77  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  43 EPDNAVSAVTVDQKQVEQKIAELQKK-EDAKKRAEDKRIRDLERRAANARKQREAEARnikklEQQRKAKEKEKAQAEAE 121
Cdd:NF033838 122 ELDAAFEQFKKDTLEPGKKVAEATKKvEEAEKKAKDQKEEDRRNYPTNTYKTLELEIA-----ESDVEVKKAELELVKEE 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 122 AKKAREIEQKERAKAKQAEKQKQEAEnaakaaadkrkaeeeaLKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQ 201
Cdd:NF033838 197 AKEPRDEEKIKQAKAKVESKKAEATR----------------LEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDK 260


                 ...
gi 567929780 202 LAK 204
Cdd:NF033838 261 PKR 263
 
Name Accession Description Interval E-value
TolA pfam06519
TolA C-terminal; This family consists of several bacterial TolA proteins as well as two ...
 213-304 2.62e-24

TolA C-terminal; This family consists of several bacterial TolA proteins as well as two eukaryotic proteins of unknown function. Tol proteins are involved in the translocation of group A colicins. Colicins are bacterial protein toxins, which are active against Escherichia coli and other related species (See pfam01024). TolA is anchored to the cytoplasmic membrane by a single membrane spanning segment near the N-terminus, leaving most of the protein exposed to the periplasm.


Pssm-ID: 399492 [Multi-domain]  Cd Length: 94  Bit Score: 94.42  E-value: 2.62e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  213 RQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVCEAALRAVRMADTLPVSKDKD 292
Cdd:pfam06519   3 GSGASGAEVDRYAGQIKQAIQSRFLKDDSFAGKTCRVRIKLAPDGTLISVKVEGGDPALCQAAKAAVAKTAKIPKPPSQD 82

                          90
                  ....*....|..
gi 567929780  293 VFEQLKNINLTI 304
Cdd:pfam06519  83 VYEKFKNINLDF 94
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 45-306 1.39e-23

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 98.76  E-value: 1.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   45 DNAVSAVTVDQKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKK 124
Cdd:TIGR02794  35 AEIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  125 AREIEQKERAKAKQAEKQKQEAENAAKAAAD--------------------------KRKAEEEALKKAEAERKKREAEA 178
Cdd:TIGR02794 115 EEKQKQAEEAKAKQAAEAKAKAEAEAERKAKeeaakqaeeeakakaaaeakkkaeeaKKKAEAEAKAKAEAEAKAKAEEA 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  179 KERAKEAERKRQQALQEQMLQEQLAKEQAARSK------------------------IRQQQVVSEVDKYRALIMARIQQ 234
Cdd:TIGR02794 195 KAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERkadeaelgdifglasgsnaekqggARGAAAGSEVDKYAAIIQQAIQQ 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 567929780  235 NLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVCEAALRAVRMADTLPVSKDKDVFEQLKNINLTIKP 306
Cdd:TIGR02794 275 NLYDDPSFRGKTCRLRIRLAPDGTLLSVTKSSGDPALCQAALAAVAKAAKLPMPPSDPVYEEFKNINLTFKP 346
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 55-307 8.54e-10

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 59.05  E-value: 8.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLE----------RRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKK 124
Cdd:PRK09510 114 QEQKKQAEEAAKQAALKQKQAEEAAAKAAAaakakaeaeaKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAA 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 125 AREIEQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAK 204
Cdd:PRK09510 194 KAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLFGGLDSGKNAP 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 205 EQAARSKIRQQQVV------------SEVDKYRALIMARIQQNLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVC 272
Cdd:PRK09510 274 KTGGGAKGNGAQGAgagngkkggasgADIDQYAGQIKSAIQSKFYDASSYAGKTCTLRIKLAPDGTLLDIKKEGGDPALC 353

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 567929780 273 EAALRAVRMAdTLPVSKDKDVFEQLKNINLTIKPE 307
Cdd:PRK09510 354 QAALAAAKTA-KIPKPPSQEVYEKFKNAPLDFKPQ 387
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 37-282 3.12e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 3.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  37 LNSAIPEPDNAVSAVTVDQKQVEQKIAELQKKED---AKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEK 113
Cdd:COG1196  293 LLAELARLEQDIARLEERRRELEERLEELEEELAeleEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 114 EKAQAEAEAKKAREIEQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQAL 193
Cdd:COG1196  373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEA 452

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 194 QEQMLQEQLAKEQAARSKIRQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQ-----CRVNIRLGFNGLVTQVKSLGGD 268
Cdd:COG1196  453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGflegvKAALLLAGLRGLAGAVAVLIGV 532

                        250
                 ....*....|....
gi 567929780 269 KLVCEAALRAVRMA 282
Cdd:COG1196  533 EAAYEAALEAALAA 546
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 55-246 1.72e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.71  E-value: 1.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIE--QKE 132
Cdd:COG1196  280 ELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEeaEAE 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 133 RAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQmLQEQLAKEQAARSKI 212
Cdd:COG1196  360 LAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL-EELEEALAELEEEEE 438

                        170       180       190
                 ....*....|....*....|....*....|....
gi 567929780 213 RQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQ 246
Cdd:COG1196  439 EEEEALEEAAEEEAELEEEEEALLELLAELLEEA 472
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 57-302 1.74e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.71  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  57 QVEQKIAELQKKEDAKKRAE---DKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKER 133
Cdd:COG1196  271 ELRLELEELELELEEAQAEEyelLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 134 AKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQAARSKIR 213
Cdd:COG1196  351 EELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL 430

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 214 QQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGGDKLVCEAALRAVRMADTLPVSKDKDV 293
Cdd:COG1196  431 AELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGV 510


                 ....*....
gi 567929780 294 FEQLKNINL 302
Cdd:COG1196  511 KAALLLAGL 519
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 56-236 1.78e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 55.71  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  56 KQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQ-QRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEaQAEEYELLAELARLEQDIARLEERRREL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 135 KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQAARSKIRQ 214
Cdd:COG1196  315 EERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA 394

                        170       180
                 ....*....|....*....|..
gi 567929780 215 QQVVSEVDKYRALIMARIQQNL 236
Cdd:COG1196  395 AAELAAQLEELEEAEEALLERL 416
PTZ00121 PTZ00121
MAEBL; Provisional
 56-223 3.39e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.76  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   56 KQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREA-EARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAkKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKA 1572

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  135 KAKQ--AEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQAARSKI 212
Cdd:PTZ00121 1573 EEDKnmALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEEL 1652

                         170
                  ....*....|.
gi 567929780  213 RQQQVVSEVDK 223
Cdd:PTZ00121 1653 KKAEEENKIKA 1663
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 55-216 6.55e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.79  E-value: 6.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  55 QKQVEQKIAELQKKEdAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:COG1196  252 EAELEELEAELAELE-AELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEE 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 135 KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQAARSKIRQ 214
Cdd:COG1196  331 ELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEE 410


                 ..
gi 567929780 215 QQ 216
Cdd:COG1196  411 AL 412
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 55-246 9.45e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 9.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  55 QKQVEQKIAELQKKEDAKKRAEDkRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:COG1196  259 EAELAELEAELEELRLELEELEL-ELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEE 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 135 KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQAARSKIRQ 214
Cdd:COG1196  338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLE 417

                        170       180       190
                 ....*....|....*....|....*....|..
gi 567929780 215 QQVVSEVDKYRALIMARIQQNLLIDEKMKNQQ 246
Cdd:COG1196  418 RLEEELEELEEALAELEEEEEEEEEALEEAAE 449
PTZ00121 PTZ00121
MAEBL; Provisional
 54-223 1.48e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   54 DQKQVE--QKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQK 131
Cdd:PTZ00121 1222 DAKKAEavKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK 1301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  132 ERA--------KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKErAKEAERKRQQAlqEQMLQEQLA 203
Cdd:PTZ00121 1302 KKAdeakkkaeEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADE-AEAAEEKAEAA--EKKKEEAKK 1378

                         170       180
                  ....*....|....*....|
gi 567929780  204 KEQAARSKIRQQQVVSEVDK 223
Cdd:PTZ00121 1379 KADAAKKKAEEKKKADEAKK 1398
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 55-246 2.94e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 51.86  E-value: 2.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:COG1196  219 KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELA 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 135 KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQAARSKIRQ 214
Cdd:COG1196  299 RLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                        170       180       190
                 ....*....|....*....|....*....|..
gi 567929780 215 QQVVSEVDKYRALIMARIQQNLLIDEKMKNQQ 246
Cdd:COG1196  379 EELEELAEELLEALRAAAELAAQLEELEEAEE 410
PTZ00121 PTZ00121
MAEBL; Provisional
 63-211 3.20e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.07  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   63 AELQKKEDAKKRAEDKRIRDLERRAANARKQREAE--ARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAKAKQAE 140
Cdd:PTZ00121 1274 AEEARKADELKKAEEKKKADEAKKAEEKKKADEAKkkAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAE 1353

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 567929780  141 KQKQEAENAAKAAADKRKAEEEALKKAEAERKKreAEAKERAKEAERKrqqALQEQMLQEQLAKEQAARSK 211
Cdd:PTZ00121 1354 AAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK--AEEKKKADEAKKK---AEEDKKKADELKKAAAAKKK 1419
PTZ00121 PTZ00121
MAEBL; Provisional
 55-226 6.18e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 6.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREI------ 128
Cdd:PTZ00121 1534 KKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMkaeeak 1613

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  129 -EQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEA--LKKAEAERKKREAEAKERAKEAERKRQQALQEQmlQEQLAKE 205
Cdd:PTZ00121 1614 kAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAeeLKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAE--EDEKKAA 1691

                         170       180
                  ....*....|....*....|.
gi 567929780  206 QAARSKIRQQQVVSEVDKYRA 226
Cdd:PTZ00121 1692 EALKKEAEEAKKAEELKKKEA 1712
PTZ00121 PTZ00121
MAEBL; Provisional
 57-248 7.19e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 7.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   57 QVEQKIAELQKKEDAKKRAEDKRIRD-LERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAK 135
Cdd:PTZ00121 1409 ELKKAAAAKKKADEAKKKAEEKKKADeAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEA 1488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  136 AKQAEKQKQEAENAAKAAADKRKAEE----EALKKAEAERKKREAEAKERAKEAERKRQ-----QALQEQMLQEQLAKEQ 206
Cdd:PTZ00121 1489 KKKAEEAKKKADEAKKAAEAKKKADEakkaEEAKKADEAKKAEEAKKADEAKKAEEKKKadelkKAEELKKAEEKKKAEE 1568

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 567929780  207 AARSKIRQQQVVSEVDKYRALIMARIQQNLLIDE---KMKNQQCR 248
Cdd:PTZ00121 1569 AKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEeekKMKAEEAK 1613
PTZ00121 PTZ00121
MAEBL; Provisional
 55-226 9.22e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 9.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLeRRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:PTZ00121 1552 KKAEELKKAEEKKKAEEAKKAEEDKNMAL-RKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEE 1630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  135 KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREaeakERAKEAERKRQQALQEQMLQEQLAKEQAARSKIRQ 214
Cdd:PTZ00121 1631 EKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE----EDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE 1706

                         170
                  ....*....|..
gi 567929780  215 QQVVSEVDKYRA 226
Cdd:PTZ00121 1707 LKKKEAEEKKKA 1718
PTZ00121 PTZ00121
MAEBL; Provisional
 55-248 9.30e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.52  E-value: 9.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREA-EARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKER 133
Cdd:PTZ00121 1104 KKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEArKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARK 1183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  134 A----KAKQAEKQKQEAENAAKAAADKRKAEEEAlKKAEAERKkreAEAKERAKEAERKRQQALQEQmlqeqlakeqaar 209
Cdd:PTZ00121 1184 AeevrKAEELRKAEDARKAEAARKAEEERKAEEA-RKAEDAKK---AEAVKKAEEAKKDAEEAKKAE------------- 1246

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 567929780  210 sKIRQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQCR 248
Cdd:PTZ00121 1247 -EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK 1284
PTZ00121 PTZ00121
MAEBL; Provisional
 56-252 1.12e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   56 KQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARniKKLEQQRKAKEKEKAQAEAEAKKAREIEQKerak 135
Cdd:PTZ00121 1460 EEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAK--KAAEAKKKADEAKKAEEAKKADEAKKAEEA---- 1533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  136 aKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAK-------ERAKEAERKRQQAL------QEQMLQEQL 202
Cdd:PTZ00121 1534 -KKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKnmalrkaEEAKKAEEARIEEVmklyeeEKKMKAEEA 1612

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 567929780  203 AKEQAARSKIRQQQVVSEVDKYRALIMARIQQNLLIDEKMKNQQCRVNIR 252
Cdd:PTZ00121 1613 KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIK 1662
PTZ00121 PTZ00121
MAEBL; Provisional
 29-227 1.30e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   29 APKVMEVTLNSAIPEPDNAVSAVTVDQKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARK-QREAEARNIKKLEQQ 107
Cdd:PTZ00121 1181 ARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKaEEERNNEEIRKFEEA 1260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  108 RKAKEKEKAQAEAEAKKAREIEQK---ERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKE 184
Cdd:PTZ00121 1261 RMAHFARRQAAIKAEEARKADELKkaeEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEE 1340

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 567929780  185 AERKRQQALQEQMLQEQLAKEQAARSKIRQQQVVSEVDKYRAL 227
Cdd:PTZ00121 1341 AKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
49-211 3.72e-06

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 47.95  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  49 SAVTVDQKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQRE-AEARNIKKLEQQRKAKEKEKAQAEAEAKKARE 127
Cdd:COG2268  212 TEIAIAQANREAEEAELEQEREIETARIAEAEAELAKKKAEERREAEtARAEAEAAYEIAEANAEREVQRQLEIAERERE 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 128 IEQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQA 207
Cdd:COG2268  292 IELQEKEAEREEAELEADVRKPAEAEKQAAEAEAEAEAEAIRAKGLAEAEGKRALAEAWNKLGDAAILLMLIEKLPEIAE 371


                 ....
gi 567929780 208 ARSK 211
Cdd:COG2268  372 AAAK 375
PTZ00121 PTZ00121
MAEBL; Provisional
 55-223 6.29e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 6.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEdkrirDLERRAANARKQREAEarniKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:PTZ00121 1284 KKAEEKKKADEAKKAEEKKKAD-----EAKKKAEEAKKADEAK----KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEA 1354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  135 KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAK--------ERAKEAERKRQQALQEQMLQEQLAKEQ 206
Cdd:PTZ00121 1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKaeedkkkaDELKKAAAAKKKADEAKKKAEEKKKAD 1434

                         170
                  ....*....|....*..
gi 567929780  207 AARSKIRQQQVVSEVDK 223
Cdd:PTZ00121 1435 EAKKKAEEAKKADEAKK 1451
PTZ00121 PTZ00121
MAEBL; Provisional
 55-211 1.29e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.67  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAE----ARNIKKLEQQRK-AKEKEKAQAEAEAKKAREIE 129
Cdd:PTZ00121 1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEekkkAEELKKAEEENKiKAAEEAKKAEEDKKKAEEAK 1681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  130 QKERAKAKQAEKQKQEAENAAKAAADKRKAEEEA-----LKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAK 204
Cdd:PTZ00121 1682 KAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeeLKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAH 1761


                  ....*..
gi 567929780  205 EQAARSK 211
Cdd:PTZ00121 1762 LKKEEEK 1768
PTZ00121 PTZ00121
MAEBL; Provisional
 55-223 4.78e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEArniKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:PTZ00121 1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEED---KKKADELKKAAAAKKKADEAKKKAEEKKKADEA 1436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  135 KAKQAEKQKqeAENAAKAAADKrKAEEEALKKAEAERKKREAEAK-ERAKEAERKRQQALQEQMLQEQLAKEQAARSKIR 213
Cdd:PTZ00121 1437 KKKAEEAKK--ADEAKKKAEEA-KKAEEAKKKAEEAKKADEAKKKaEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD 1513

                         170
                  ....*....|
gi 567929780  214 QQQVVSEVDK 223
Cdd:PTZ00121 1514 EAKKAEEAKK 1523
PTZ00121 PTZ00121
MAEBL; Provisional
 60-223 7.76e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 7.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   60 QKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARniKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA----- 134
Cdd:PTZ00121 1296 KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAK--KKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAaekkk 1373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  135 --KAKQAEKQKQEAENAAKAAADKRKAEE-----EALKKAEAERK-----KREAEAKERAKEAERKRQQALQEQMLQ--- 199
Cdd:PTZ00121 1374 eeAKKKADAAKKKAEEKKKADEAKKKAEEdkkkaDELKKAAAAKKkadeaKKKAEEKKKADEAKKKAEEAKKADEAKkka 1453

                         170       180
                  ....*....|....*....|....
gi 567929780  200 EQLAKEQAARSKIRQQQVVSEVDK 223
Cdd:PTZ00121 1454 EEAKKAEEAKKKAEEAKKADEAKK 1477
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 161-213 1.17e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 1.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 567929780  161 EEALKKA--EAERKKREAEAKERAKEAERKRQQALQEQmlQEQLAKEQAARSKIR 213
Cdd:pfam03154 590 EEALEKAkrEAEQKAREEKEREKEKEKERERERERERE--AERAAKASSSSHEGR 642
PRK12704 PRK12704
phosphodiesterase; Provisional
 58-234 1.52e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  58 VEQKIAElQKKEDAKKRAEdKRIRDLERRAANARKQREAEARN-IKKLEQQrkakekekaqaeaeakKAREIEQKeRAKA 136
Cdd:PRK12704  24 VRKKIAE-AKIKEAEEEAK-RILEEAKKEAEAIKKEALLEAKEeIHKLRNE----------------FEKELRER-RNEL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 137 KQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEqmLQE--QLAKEQAarskirQ 214
Cdd:PRK12704  85 QKLEKRLLQKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQE--LERisGLTAEEA------K 156

                        170       180
                 ....*....|....*....|.
gi 567929780 215 QQVVSEV-DKYRALIMARIQQ 234
Cdd:PRK12704 157 EILLEKVeEEARHEAAVLIKE 177
PTZ00121 PTZ00121
MAEBL; Provisional
 57-223 1.62e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   57 QVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARniKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAKA 136
Cdd:PTZ00121 1382 AAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAK--KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKA 1459

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  137 KQAEK---QKQEAENAAKAAADKrKAEEEALKKAEAERKKRE-----AEAKERAKEAERKRQQALQEQMLQEQLAKEQAA 208
Cdd:PTZ00121 1460 EEAKKkaeEAKKADEAKKKAEEA-KKADEAKKKAEEAKKKADeakkaAEAKKKADEAKKAEEAKKADEAKKAEEAKKADE 1538

                         170
                  ....*....|....*
gi 567929780  209 RSKIRQQQVVSEVDK 223
Cdd:PTZ00121 1539 AKKAEEKKKADELKK 1553
PTZ00121 PTZ00121
MAEBL; Provisional
 60-223 3.83e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   60 QKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAKaKQA 139
Cdd:PTZ00121 1342 KKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAK-KKA 1420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  140 EKQKQEAENAAKAAADKRKAEE-----EALKKAEAERKKREAEAK-ERAKEAERKRQQALQEQMLQEQLAKEQAARSKIR 213
Cdd:PTZ00121 1421 DEAKKKAEEKKKADEAKKKAEEakkadEAKKKAEEAKKAEEAKKKaEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKAD 1500

                         170
                  ....*....|
gi 567929780  214 QQQVVSEVDK 223
Cdd:PTZ00121 1501 EAKKAAEAKK 1510
PTZ00121 PTZ00121
MAEBL; Provisional
 55-208 3.93e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:PTZ00121 1628 AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEEL 1707

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 567929780  135 KAKQAEKQKQEAENAAKAAADKRKAeeEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQAA 208
Cdd:PTZ00121 1708 KKKEAEEKKKAEELKKAEEENKIKA--EEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEA 1779
PTZ00121 PTZ00121
MAEBL; Provisional
 56-223 4.08e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 4.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   56 KQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAK 135
Cdd:PTZ00121 1325 EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDK 1404

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  136 AKQAEKQKQEAENAA----KAAADKRKAEEEALKKAEAERKKREAEAK-ERAKEAERKRQQALQEQMLQEQLAKEQAARS 210
Cdd:PTZ00121 1405 KKADELKKAAAAKKKadeaKKKAEEKKKADEAKKKAEEAKKADEAKKKaEEAKKAEEAKKKAEEAKKADEAKKKAEEAKK 1484

                         170
                  ....*....|...
gi 567929780  211 KIRQQQVVSEVDK 223
Cdd:PTZ00121 1485 ADEAKKKAEEAKK 1497
PTZ00121 PTZ00121
MAEBL; Provisional
 55-226 6.66e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 6.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREA-EARNIKKLEQQRKAKEKEKAQAEAEAKKAR----EIE 129
Cdd:PTZ00121 1164 RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAArKAEEERKAEEARKAEDAKKAEAVKKAEEAKkdaeEAK 1243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  130 QKERAKAKQAEKQKQEAENAAKAAADKRKAEEEA-----LKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAK 204
Cdd:PTZ00121 1244 KAEEERNNEEIRKFEEARMAHFARRQAAIKAEEArkadeLKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323

                         170       180
                  ....*....|....*....|..
gi 567929780  205 EQAARSKIRQQQVVSEVDKYRA 226
Cdd:PTZ00121 1324 AEEAKKKADAAKKKAEEAKKAA 1345
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 55-212 8.48e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.88  E-value: 8.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEarNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERA 134
Cdd:pfam17380 407 LEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREME--RVRLEEQERQQQVERLRQQEEERKRKKLELEKEKR 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  135 KAKQAEKQKQEAENAAKAAADKRKAEEE----ALKKAEAERKKREAEAKER--AKEAERKRQQALQEQMLQEQLAKEQAA 208
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEErkrkLLEKEMEERQKAIYEEERRreAEEERRKQQEMEERRRIQEQMRKATEE 564


                  ....
gi 567929780  209 RSKI 212
Cdd:pfam17380 565 RSRL 568
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 63-232 1.01e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 40.70  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  63 AELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQ------------ 130
Cdd:PRK05035 436 AEIRAIEQEKKKAEEAKARFEARQARLEREKAAREARHKKAAEARAAKDKDAVAAALARVKAKKAAATqpivikagarpd 515

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 131 -----KERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAeRKKREAEAKERAKEAERKRQQALQEQMLQEQLAKE 205
Cdd:PRK05035 516 nsaviAAREARKAQARARQAEKQAAAAADPKKAAVAAAIARAKA-KKAAQQAANAEAEEEVDPKKAAVAAAIARAKAKKA 594

                        170       180
                 ....*....|....*....|....*..
gi 567929780 206 QAARSKIRQQQVVSEVDKYRALIMARI 232
Cdd:PRK05035 595 AQQAASAEPEEQVAEVDPKKAAVAAAI 621
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 43-204 1.04e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.77  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  43 EPDNAVSAVTVDQKQVEQKIAELQKK-EDAKKRAEDKRIRDLERRAANARKQREAEARnikklEQQRKAKEKEKAQAEAE 121
Cdd:NF033838 122 ELDAAFEQFKKDTLEPGKKVAEATKKvEEAEKKAKDQKEEDRRNYPTNTYKTLELEIA-----ESDVEVKKAELELVKEE 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 122 AKKAREIEQKERAKAKQAEKQKQEAEnaakaaadkrkaeeeaLKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQ 201
Cdd:NF033838 197 AKEPRDEEKIKQAKAKVESKKAEATR----------------LEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDK 260


                 ...
gi 567929780 202 LAK 204
Cdd:NF033838 261 PKR 263
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 56-144 1.40e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.20  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  56 KQVEQKIAELQKKEDAKKRAEDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAK 135
Cdd:PRK00409 544 KEAEKLKEELEEKKEKLQEEEDKLLEEAEKEAQQAIKEAKKEADEIIKELRQLQKGGYASVKAHELIEARKRLNKANEKK 623


                 ....*....
gi 567929780 136 AKQAEKQKQ 144
Cdd:PRK00409 624 EKKKKKQKE 632
PTZ00121 PTZ00121
MAEBL; Provisional
 55-223 3.35e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   55 QKQVEQKIAELQKKEDAKKRAEDKRIRDLE--RRAANARKQRE-----AEARNIKKLEQQRKAKEKEKAQAEAEAKKarE 127
Cdd:PTZ00121 1615 AEEAKIKAEELKKAEEEKKKVEQLKKKEAEekKKAEELKKAEEenkikAAEEAKKAEEDKKKAEEAKKAEEDEKKAA--E 1692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  128 IEQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEaERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKEQA 207
Cdd:PTZ00121 1693 ALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAE-EAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAE 1771

                         170
                  ....*....|....*.
gi 567929780  208 ARSKIRQQQVVSEVDK 223
Cdd:PTZ00121 1772 EIRKEKEAVIEEELDE 1787
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 53-211 5.81e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.18  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   53 VDQKQVEQKIAELQKKEDAKKRA-EDKRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQK 131
Cdd:pfam17380 425 IRAEQEEARQREVRRLEEERAREmERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEER 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  132 ERA------KAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQEQLAKE 205
Cdd:pfam17380 505 KQAmieeerKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVES 584


                  ....*.
gi 567929780  206 QAARSK 211
Cdd:pfam17380 585 EKARAE 590
PRK12705 PRK12705
hypothetical protein; Provisional
 78-230 8.96e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 37.38  E-value: 8.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  78 KRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAKAKQAEKQKQEAENAAKAAADKR 157
Cdd:PRK12705  28 RQRLAKEAERILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREELQREEERLVQKEEQLDARAEKLDNLENQL 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 567929780 158 KAEEEALKKAEAERKKREAEAKERAKEAERKRQQALQEQMLQE---QLAKEQAARSKIRQQQVVSEVDKYRALIMA 230
Cdd:PRK12705 108 EEREKALSARELELEELEKQLDNELYRVAGLTPEQARKLLLKLldaELEEEKAQRVKKIEEEADLEAERKAQNILA 183
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
56-238 9.59e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 37.44  E-value: 9.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780  56 KQVEQKIAELQKKEDAKKRAEDkRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKEKAQAEAEAKKAREIEQKERAK 135
Cdd:COG4717   74 KELEEELKEAEEKEEEYAELQE-ELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELE 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780 136 AKQAEKQKQEAENAAKAAADkrkaeEEALKKAEAERKKREAEAKERAKEAERKRQQALQE-QMLQEQLAKEQAARSKIRQ 214
Cdd:COG4717  153 ERLEELRELEEELEELEAEL-----AELQEELEELLEQLSLATEEELQDLAEELEELQQRlAELEEELEEAQEELEELEE 227

                        170       180
                 ....*....|....*....|....
gi 567929780 215 QQVVSEVDKYRALIMARIQQNLLI 238
Cdd:COG4717  228 ELEQLENELEAAALEERLKEARLL 251
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 38-280 9.95e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 37.73  E-value: 9.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780    38 NSAIPEPDNAVSAVTVDQKQVEQKIAELQKK-EDAKKRAED--KRIRDLERRAANARKQREAEARNIKKLEQQRKAKEKE 114
Cdd:TIGR02168  669 NSSILERRREIEELEEKIEELEEKIAELEKAlAELRKELEEleEELEQLRKELEELSRQISALRKDLARLEAEVEQLEER 748

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   115 KAQAEAEAKKAREIEQKERAKAKQAEKQKQEAENAAKAAADKRKAEEEALKKAEAERKKREAEA---KERAKEAERKRQQ 191
Cdd:TIGR02168  749 IAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELtllNEEAANLRERLES 828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 567929780   192 ALQEQMLQEQLAKEQAARSKIRQQQVVS---EVDKYRALIM-ARIQQNLLIDEKMKNQQCRVNIRLGFNGLVTQVKSLGG 267
Cdd:TIGR02168  829 LERRIAATERRLEDLEEQIEELSEDIESlaaEIEELEELIEeLESELEALLNERASLEEALALLRSELEELSEELRELES 908

                          250
                   ....*....|...
gi 567929780   268 DKLVCEAALRAVR 280
Cdd:TIGR02168  909 KRSELRRELEELR 921
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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