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Conserved domains on  [gi|568065183|ref|WP_024052845|]
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MULTISPECIES: FeoA family protein [Streptococcus]

Protein Classification

FeoA family protein( domain architecture ID 10004922)

FeoA family protein similar to ferrous iron transport protein A (FeoA), which is part of the Feo (ferrous iron-transport) system that functions in the uptake of ferrous iron

CATH:  2.30.30.90
Gene Ontology:  GO:0046914|GO:0006826
PubMed:  26684538|8407793|35012344
TCDB:  9.A.8.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
79-151 5.55e-24

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


:

Pssm-ID: 441522  Cd Length: 73  Bit Score: 88.65  E-value: 5.55e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183  79 LPLSELAVGDVAYIEAIHADGVLKRRLMDMGLTKNTKVQLQKVAPLGDPLEIKLRGYDLTLRKSEASLVSVVK 151
Cdd:COG1918    1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
1-71 2.71e-07

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


:

Pssm-ID: 441522  Cd Length: 73  Bit Score: 45.51  E-value: 2.71e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183   1 MDLSRITLLTEYEIVGIDLEEASVRHLADLGIKIGSFIQVISKT--NDTAILLVRAARIALDNSILKKLDVVP 71
Cdd:COG1918    1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAplGGPLVVRVGGTRIALRREEAAKILVEP 73
 
Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
79-151 5.55e-24

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 88.65  E-value: 5.55e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183  79 LPLSELAVGDVAYIEAIHADGVLKRRLMDMGLTKNTKVQLQKVAPLGDPLEIKLRGYDLTLRKSEASLVSVVK 151
Cdd:COG1918    1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 80-151 4.91e-19

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 76.09  E-value: 4.91e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183   80 PLSELAVGDVAYIEAIHA-DGVLKRRLMDMGLTKNTKVQLQKVAPLGDPLEIKLRGYDLTLRKSEASLVSVVK 151
Cdd:pfam04023   2 PLSELKEGETARIVRIRDgDPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 79-151 2.89e-14

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 63.74  E-value: 2.89e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568065183    79 LPLSELAVGDVAYIEAI-HADGVLKRRLMDMGLTKNTKVQLQKVAPLGdPLEIKLRGyDLTLRKSEASLVSVVK 151
Cdd:smart00899   1 MPLSELKPGEKARIVRIrDEDPELLRRLLELGLVPGTEVTVLRKAPFG-PLVVRVGG-ELALRREEAEKIFVEP 72
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
1-71 2.71e-07

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 45.51  E-value: 2.71e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183   1 MDLSRITLLTEYEIVGIDLEEASVRHLADLGIKIGSFIQVISKT--NDTAILLVRAARIALDNSILKKLDVVP 71
Cdd:COG1918    1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAplGGPLVVRVGGTRIALRREEAAKILVEP 73
feoA PRK09555
ferrous iron transporter A;
102-150 7.19e-06

ferrous iron transporter A;


Pssm-ID: 181949  Cd Length: 74  Bit Score: 41.66  E-value: 7.19e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 568065183 102 KRRLMDMGLTKNTKVQLQKVAPLGDPLEIKLRGYDLTLRKSEASLVSVV 150
Cdd:PRK09555  23 RQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLELE 71
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 1-71 4.28e-05

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 39.49  E-value: 4.28e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568065183    1 MDLSRITLLTEYEIVGI-DLEEASVRHLADLGIKIGSFIQVISKT--NDTAILLVRAARIALDNSILKKLDVVP 71
Cdd:pfam04023   1 MPLSELKEGETARIVRIrDGDPELLRRLLELGLVPGAEVTVVRKApfGGPIIVRVGGTRIALRREEASKIFVEP 74
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 1-71 1.20e-04

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 38.32  E-value: 1.20e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568065183     1 MDLSRITLLTEYEIVGI-DLEEASVRHLADLGIKIGSFIQVISKTNDTAILLVRAARIALDNSILKKLDVVP 71
Cdd:smart00899   1 MPLSELKPGEKARIVRIrDEDPELLRRLLELGLVPGTEVTVLRKAPFGPLVVRVGGELALRREEAEKIFVEP 72
 
Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
79-151 5.55e-24

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 88.65  E-value: 5.55e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183  79 LPLSELAVGDVAYIEAIHADGVLKRRLMDMGLTKNTKVQLQKVAPLGDPLEIKLRGYDLTLRKSEASLVSVVK 151
Cdd:COG1918    1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAPLGGPLVVRVGGTRIALRREEAAKILVEP 73
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 80-151 4.91e-19

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 76.09  E-value: 4.91e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183   80 PLSELAVGDVAYIEAIHA-DGVLKRRLMDMGLTKNTKVQLQKVAPLGDPLEIKLRGYDLTLRKSEASLVSVVK 151
Cdd:pfam04023   2 PLSELKEGETARIVRIRDgDPELLRRLLELGLVPGAEVTVVRKAPFGGPIIVRVGGTRIALRREEASKIFVEP 74
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 79-151 2.89e-14

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 63.74  E-value: 2.89e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568065183    79 LPLSELAVGDVAYIEAI-HADGVLKRRLMDMGLTKNTKVQLQKVAPLGdPLEIKLRGyDLTLRKSEASLVSVVK 151
Cdd:smart00899   1 MPLSELKPGEKARIVRIrDEDPELLRRLLELGLVPGTEVTVLRKAPFG-PLVVRVGG-ELALRREEAEKIFVEP 72
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
1-71 2.71e-07

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 45.51  E-value: 2.71e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568065183   1 MDLSRITLLTEYEIVGIDLEEASVRHLADLGIKIGSFIQVISKT--NDTAILLVRAARIALDNSILKKLDVVP 71
Cdd:COG1918    1 MTLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAplGGPLVVRVGGTRIALRREEAAKILVEP 73
feoA PRK09555
ferrous iron transporter A;
102-150 7.19e-06

ferrous iron transporter A;


Pssm-ID: 181949  Cd Length: 74  Bit Score: 41.66  E-value: 7.19e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 568065183 102 KRRLMDMGLTKNTKVQLQKVAPLGDPLEIKLRGYDLTLRKSEASLVSVV 150
Cdd:PRK09555  23 RQKLLSLGMLPGSSFNVVRVAPLGDPIHIETRRVSLVLRKKDLALLELE 71
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 1-71 4.28e-05

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 39.49  E-value: 4.28e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568065183    1 MDLSRITLLTEYEIVGI-DLEEASVRHLADLGIKIGSFIQVISKT--NDTAILLVRAARIALDNSILKKLDVVP 71
Cdd:pfam04023   1 MPLSELKEGETARIVRIrDGDPELLRRLLELGLVPGAEVTVVRKApfGGPIIVRVGGTRIALRREEASKIFVEP 74
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 1-71 1.20e-04

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 38.32  E-value: 1.20e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568065183     1 MDLSRITLLTEYEIVGI-DLEEASVRHLADLGIKIGSFIQVISKTNDTAILLVRAARIALDNSILKKLDVVP 71
Cdd:smart00899   1 MPLSELKPGEKARIVRIrDEDPELLRRLLELGLVPGTEVTVLRKAPFGPLVVRVGGELALRREEAEKIFVEP 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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