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Conserved domains on  [gi|585342505|ref|WP_024224130|]
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helix-turn-helix domain-containing protein [Escherichia coli]

Protein Classification

MarR family transcriptional regulator( domain architecture ID 10581578)

MarR family transcriptional regulator containing a DNA-binding helix-turn-helix (HTH) domain, may act as a transcriptional activator or as a transcriptional repressor in controlling the expression of genes encoding metabolic enzymes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
30-97 5.98e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


:

Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.49  E-value: 5.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 585342505   30 SGLSRSAGHILSQCANLAATTSeyfihkphRLIAAETGYSQSTVVRAFREAVNKGILSVEIVIGDHRE 97
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTV--------AELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
 
Name Accession Description Interval E-value
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
30-97 5.98e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.49  E-value: 5.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 585342505   30 SGLSRSAGHILSQCANLAATTSeyfihkphRLIAAETGYSQSTVVRAFREAVNKGILSVEIVIGDHRE 97
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTV--------AELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
 
Name Accession Description Interval E-value
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
30-97 5.98e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.49  E-value: 5.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 585342505   30 SGLSRSAGHILSQCANLAATTSeyfihkphRLIAAETGYSQSTVVRAFREAVNKGILSVEIVIGDHRE 97
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTV--------AELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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