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Conserved domains on  [gi|636784589|ref|WP_024320802|]
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EF-hand domain-containing protein [Rhizobium ruizarguesonis]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
21-115 3.45e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.62  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636784589  21 LDKNGDGVISADELAAASQSSTSATASTDSDDSSTDI-VKKITADILSLMLSMQKTDGS------DDQGDGS-------- 85
Cdd:COG5126   14 LDADGDGVLERDDFEALFRRLWATLFSEADTDGDGRIsREEFVAGMESLFEATVEPFARaafdllDTDGDGKisadefrr 93

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 636784589  86 -----DQSDDASKGVFAAMDTNGDGKLTESEFLAA 115
Cdd:COG5126   94 lltalGVSEEEADELFARLDTDGDGKISFEEFVAA 128
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
21-115 3.45e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.62  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636784589  21 LDKNGDGVISADELAAASQSSTSATASTDSDDSSTDI-VKKITADILSLMLSMQKTDGS------DDQGDGS-------- 85
Cdd:COG5126   14 LDADGDGVLERDDFEALFRRLWATLFSEADTDGDGRIsREEFVAGMESLFEATVEPFARaafdllDTDGDGKisadefrr 93

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 636784589  86 -----DQSDDASKGVFAAMDTNGDGKLTESEFLAA 115
Cdd:COG5126   94 lltalGVSEEEADELFARLDTDGDGKISFEEFVAA 128
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 21-115 1.43e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.22  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636784589  21 LDKNGDGVISADELAAasqsstsatastdsddsstdIVKKItadilslmlsmqktdgsddqgdGSDQSDDASKGVFAAMD 100
Cdd:cd00051    9 FDKDGDGTISADELKA--------------------ALKSL----------------------GEGLSEEEIDEMIREVD 46

                         90
                 ....*....|....*
gi 636784589 101 TNGDGKLTESEFLAA 115
Cdd:cd00051   47 KDGDGKIDFEEFLEL 61
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
21-115 3.45e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.62  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636784589  21 LDKNGDGVISADELAAASQSSTSATASTDSDDSSTDI-VKKITADILSLMLSMQKTDGS------DDQGDGS-------- 85
Cdd:COG5126   14 LDADGDGVLERDDFEALFRRLWATLFSEADTDGDGRIsREEFVAGMESLFEATVEPFARaafdllDTDGDGKisadefrr 93

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 636784589  86 -----DQSDDASKGVFAAMDTNGDGKLTESEFLAA 115
Cdd:COG5126   94 lltalGVSEEEADELFARLDTDGDGKISFEEFVAA 128
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 21-115 1.43e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.22  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636784589  21 LDKNGDGVISADELAAasqsstsatastdsddsstdIVKKItadilslmlsmqktdgsddqgdGSDQSDDASKGVFAAMD 100
Cdd:cd00051    9 FDKDGDGTISADELKA--------------------ALKSL----------------------GEGLSEEEIDEMIREVD 46

                         90
                 ....*....|....*
gi 636784589 101 TNGDGKLTESEFLAA 115
Cdd:cd00051   47 KDGDGKIDFEEFLEL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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