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Conserved domains on  [gi|636787836|ref|WP_024323995|]
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metalloregulator ArsR/SmtB family transcription factor [Rhizobium ruizarguesonis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
repress_SdpR super family cl41436
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-84 3.97e-30

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


The actual alignment was detected with superfamily member NF033789:

Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 102.88  E-value: 3.97e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636787836  21 VFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-84 3.97e-30

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 102.88  E-value: 3.97e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636787836  21 VFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
17-84 6.62e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.95  E-value: 6.62e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636787836  17 AAQRVFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:COG0640    9 ELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRL 76
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-84 1.28e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 88.67  E-value: 1.28e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636787836  18 AQRVFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRL 67
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-84 9.71e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 9.71e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636787836  22 FHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL 63
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-97 5.24e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.86  E-value: 5.24e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 636787836    32 KILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSLIENNLVNTLNGFV 97
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 19-78 2.02e-14

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 62.56  E-value: 2.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636787836   19 QRVFHALSSAPRRKILAYL-SASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQ 78
Cdd:pfam12840   1 DDVAEALADPTRLRILRALvGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 20-84 3.15e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.89  E-value: 3.15e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 636787836  20 RVFHALSSAPRRKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRESGeLCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-84 3.97e-30

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 102.88  E-value: 3.97e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 636787836  21 VFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
17-84 6.62e-25

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 89.95  E-value: 6.62e-25
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 636787836  17 AAQRVFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:COG0640    9 ELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRL 76
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-84 1.28e-24

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 88.67  E-value: 1.28e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636787836  18 AQRVFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRL 67
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-84 9.71e-20

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 76.57  E-value: 9.71e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636787836  22 FHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSL 63
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-97 5.24e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 71.86  E-value: 5.24e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 636787836    32 KILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSLIENNLVNTLNGFV 97
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
19-84 4.95e-16

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 69.14  E-value: 4.95e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 636787836  19 QRVFHALSSAPRRKILAYLSAS-GLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:COG3398   88 KKILAYLRRETPRRILLYLLENpGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYL 154
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
18-100 1.61e-15

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 66.52  E-value: 1.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636787836  18 AQRVFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIR----REKQGQFVHYSLIENNLVNTL 93
Cdd:COG4189    9 SLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRteykPGKRGRQKICYLRVDKILIVL 88


                 ....*..
gi 636787836  94 NGFVQEV 100
Cdd:COG4189   89 PGLDESD 95
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
20-77 7.14e-15

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 65.06  E-value: 7.14e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 636787836  20 RVFHALSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQG 77
Cdd:COG1777    9 RLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREG 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 19-78 2.02e-14

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 62.56  E-value: 2.02e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636787836   19 QRVFHALSSAPRRKILAYL-SASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQ 78
Cdd:pfam12840   1 DDVAEALADPTRLRILRALvGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 30-71 4.21e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.60  E-value: 4.21e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 636787836   30 RRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLI 71
Cdd:pfam01022   4 RLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
24-76 6.50e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 56.86  E-value: 6.50e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 636787836  24 ALSSAPRRKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQ 76
Cdd:COG2345    9 ALADPTRRRILELLKRAGpVTAAELAEALGLTPNAVRRHLDALEEEGLVERETE 62
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 31-86 4.25e-09

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 49.53  E-value: 4.25e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 636787836  31 RKILAYLSASG--LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSLIE 86
Cdd:COG2512   18 RRVLELLRENGgrMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPE 75
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 33-74 2.62e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.81  E-value: 2.62e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 636787836   33 ILAYLSAS-GLTAGEIADRFSMSKPAVSQHLSILEAAGLIRRE 74
Cdd:pfam12802  10 VLLALARNpGLTVAELARRLGISKQTVSRLVKRLEAKGLVERE 52
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 20-84 3.15e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 47.89  E-value: 3.15e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 636787836  20 RVFHALSSAPRRKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHYSL 84
Cdd:PRK10141   8 QLFKILSDETRLGIVLLLRESGeLCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
32-76 3.65e-08

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 48.78  E-value: 3.65e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 636787836  32 KILA--YLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQ 76
Cdd:COG1510   31 RIYAllYLSDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRK 77
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
27-75 4.49e-08

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 48.04  E-value: 4.49e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 636787836  27 SAPRRKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREK 75
Cdd:COG1846   37 TPAQFRVLAALAEAGgLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREP 86
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
23-82 1.44e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 47.18  E-value: 1.44e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 636787836  23 HALSSAPRRKILAYLSAS-GLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFVHY 82
Cdd:COG3398   16 NVLDNDTRRRIYEYIRENpGIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRY 76
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
25-74 1.39e-06

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 45.27  E-value: 1.39e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 636787836  25 LSSAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRRE 74
Cdd:COG4742   13 FLSEKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIERD 62
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
30-71 1.40e-06

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 42.04  E-value: 1.40e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 636787836   30 RRKILAYLSA-SGLTAGEIADRFSMSKPAVSQHLSILEAAGLI 71
Cdd:pfam13412   3 DRKILNLLQEnPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
27-75 3.86e-06

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 42.20  E-value: 3.86e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 636787836    27 SAPRRKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREK 75
Cdd:smart00347   9 TPTQFLVLRILYEEGpLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREP 58
Smf COG0758
Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake ...
 27-80 1.43e-05

Predicted Rossmann fold nucleotide-binding protein DprA/Smf involved in DNA uptake [Replication, recombination and repair];


Pssm-ID: 440521 [Multi-domain]  Cd Length: 360  Bit Score: 42.38  E-value: 1.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 636787836  27 SAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFV 80
Cdd:COG0758  305 DPEEKRVLDALGPEPVSIDELARRTGLPVAEVLAALLELELKGLVERLPGGRYS 358
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
31-73 2.23e-05

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 40.92  E-value: 2.23e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 636787836  31 RKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRR 73
Cdd:COG1522    8 RRILRLLQEDGrLSFAELAERVGLSESTVLRRVRRLEEAGVIRG 51
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-75 2.30e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 36.37  E-value: 2.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 636787836   27 SAPRRKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREK 75
Cdd:pfam01047   2 TLTQFHILRILYEHGpLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSR 51
DprA_WH pfam17782
DprA winged helix domain; This winged helix domain is found in the DprA protein.
 27-73 4.10e-04

DprA winged helix domain; This winged helix domain is found in the DprA protein.


Pssm-ID: 436040 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 636787836   27 SAPRRKILAYLSASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRR 73
Cdd:pfam17782  11 DADEARVLAALGPDPVSVDELVRRTGLPAAEVSAALLELELAGRVER 57
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
 31-71 6.59e-04

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 35.10  E-value: 6.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 636787836   31 RKILAYLSAS--GLTAGEIADRFSMSKPAVSQHLSILEAAGLI 71
Cdd:pfam08279   1 LQILQLLLEArgPISGQELAEKLGVSRRTIRRDIKILEELGVP 43
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
43-77 6.62e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 36.72  E-value: 6.62e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 636787836  43 TAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQG 77
Cdd:COG1321   26 RTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYG 60
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
28-73 9.65e-04

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 36.47  E-value: 9.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 636787836  28 APRRKILAYLSASG--LTAGEIADRF-----SMSKPAVSQHLSILEAAGLIRR 73
Cdd:COG0735   20 PQRLAILELLLESDrhLSAEEIYEALrkkgpSISLATVYRTLDLLVEAGLVHR 72
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
30-75 1.08e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 36.92  E-value: 1.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 636787836  30 RRKILAYLS---ASGLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREK 75
Cdd:COG3888    5 REKILRILKnygGEGIPQSELVRLLGASKSRVSEILSELEKEGLIARKK 53
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 42-80 1.49e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 34.56  E-value: 1.49e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 636787836  42 LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQFV 80
Cdd:cd00092   26 LTRQEIADYLGLTRETVSRTLKELEEEGLISRRGRGKYR 64
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 27-74 1.53e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 36.43  E-value: 1.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 636787836  27 SAPRRKILAYLSASGLTAG------EIADRFSMSKPAVSQHLSILEAAGLIRRE 74
Cdd:COG1974    5 TKRQREILDFIKEYIRERGyppsqrEIAEALGLSSSAVHRHLKALEKKGYLRRD 58
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
46-75 1.56e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 33.95  E-value: 1.56e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 636787836    46 EIADRFSMSKPAVSQHLSILEAAGLIRREK 75
Cdd:smart00419  13 EIAELLGLTRETVSRTLKRLEKEGLISREG 42
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
32-89 1.86e-03

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 34.87  E-value: 1.86e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 636787836    32 KILAYLSAS--GLTAGEIADRFSMSKPAVSQHLSILEAAGLIRREKQGQfvHYSLIENNL 89
Cdd:smart00346   9 AVLRALAEEpgGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNG--RYRLGPKVL 66
PRK11402 PRK11402
transcriptional regulator PhoB;
43-118 2.40e-03

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 35.97  E-value: 2.40e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636787836  43 TAGEIADRFSMSKPAVSQHLSILEAAG-LIRREKQGQFVHYSLIENNLVnTLNGFVQEVCPVGRPIKKE--SQARTRAK 118
Cdd:PRK11402  35 TENELCTQYNVSRITIRKAISDLVADGvLIRWQGKGTFVQSQKVENALL-TVSGFTDFGVSQGKATKEKviEQERVSAA 112
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
3-75 4.28e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 34.55  E-value: 4.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636787836   3 EETFDDAVEgssvsaaqrVFHALSSAPRRkILAYLSASG--LTAGEIADRFSMSKPAVSQHLSILEAAGLIRREK 75
Cdd:COG3355   12 EPDLEDVLE---------CVYGLSETDAE-VYLILLENGepLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREK 76
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 30-73 4.85e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 35.11  E-value: 4.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 636787836  30 RRKILAYLSASG-LTAGEIADRFSMSKPAVSQHLSILEAAGLIRR 73
Cdd:COG1349    7 RQKILELLRERGrVSVEELAERLGVSEETIRRDLAELEEQGLLRR 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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