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MULTISPECIES: choline trimethylamine-lyase [Streptococcus]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
choline_CutC super family
cl37434 choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and ...
60-848
0e+00
choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines]
TIGR04394 :Pssm-ID: 275187 [Multi-domain]
Cd Length: 789
Bit Score: 1568.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 60 I T P RL QA LK NQ YLK AQ P T I SLL RA TNL T R I S KEN E GMPK AI LR GT AF KEF C KI AP V VIQD N EL L VGAP N G GA R F GAFSPD 139
Cdd:TIGR04394 1 P T E RL VR LK EN YLK QV P S I TIY RA RAI T E I A KEN P GMPK IL LR AK AF RKC C ET AP L VIQD D EL I VGAP C G AP R A GAFSPD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 140 I S WRWLRDE I DT VS TRPQDP YAL SEEDKK VL REEIFP Y WEG R S V DE A CE T QYREAG A WELSGESFVSDCSYHA CS GGGDS 219
Cdd:TIGR04394 81 I A WRWLRDE L DT IG TRPQDP FYI SEEDKK IM REEIFP F WEG K S L DE Y CE D QYREAG V WELSGESFVSDCSYHA VN GGGDS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 220 NPGYDV VG M R KGMLDI K AEA EA HL SK L D Y G NP D D LE KIYFYK AQ I L T A EGVMIYAKR M SE H AAELAAKE LN PKRKAELE M 299
Cdd:TIGR04394 161 NPGYDV IL M K KGMLDI Q AEA KE HL AE L S Y E NP E D ID KIYFYK SV I D T T EGVMIYAKR L SE Y AAELAAKE QD PKRKAELE K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 300 I SR VNA N VPAHKP E TFWEA M Q Y V V T IQH LL LC EENQTG L SIGRVDQYMYP L YK R DIEAGRM ND Y Q AFELAGCM F IKMSEM 379
Cdd:TIGR04394 241 I AE VNA R VPAHKP R TFWEA I Q S V W T VES LL VV EENQTG M SIGRVDQYMYP F YK A DIEAGRM TE Y E AFELAGCM L IKMSEM 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 380 MWLTSEG S SKFFAGYQPFVNMCVGGVTREG R DATNDLTYLLMDA I RHVKVYQP T LA T RI N NKSP R KYLKKIVDVVRAG I G 459
Cdd:TIGR04394 321 MWLTSEG G SKFFAGYQPFVNMCVGGVTREG G DATNDLTYLLMDA V RHVKVYQP S LA C RI H NKSP Q KYLKKIVDVVRAG M G 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 460 FPACHFDD S HIKMMLAKGVS M EDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPI L IE TT LNHG I PLWYGK P V T PD M G S L D 539
Cdd:TIGR04394 401 FPACHFDD A HIKMMLAKGVS I EDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPI C IE LV LNHG V PLWYGK Q V C PD T G D L S 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 540 Q YK T F E Q F E AAVKE T IKY V TKW TS V M TVISQRV Q R E LAP A PLMS M MYEG T ME N G RG V KS GGAMYNFGPGVVWSGLA N YAD 619
Cdd:TIGR04394 481 Q FD T Y E K F D AAVKE Q IKY I TKW SA V A TVISQRV H R D LAP K PLMS L MYEG C ME K G KD V SA GGAMYNFGPGVVWSGLA T YAD 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 620 SMAAIKKLV FE DKKYTL DE LN K AL I A D FEGY D QIRADCL A APKYGNDDDY V D YF A S D IIE FTE E EHRKYKTLYS V LSHGT 699
Cdd:TIGR04394 561 SMAAIKKLV YD DKKYTL EQ LN E AL K A N FEGY E QIRADCL D APKYGNDDDY A D LI A A D LVN FTE R EHRKYKTLYS H LSHGT 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 700 LSISNNTP L GQ I TGASA S GR R AWTPLSDGISP DH G M D T KGPTAIIKSVSKMAN EN MNIGMVHNFK I M A GLLDTP Q GE ES L 779
Cdd:TIGR04394 641 LSISNNTP F GQ L TGASA N GR L AWTPLSDGISP TQ G A D F KGPTAIIKSVSKMAN DS MNIGMVHNFK L M S GLLDTP E GE NG L 720
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636996776 780 ITLLRTASILGNGEMQFNYLDN AI LLDAQQHPEKYRDL I VRVAGYSAFFVELCKDVQDEII A RT V L TRI 848
Cdd:TIGR04394 721 ITLLRTASILGNGEMQFNYLDN ET LLDAQQHPEKYRDL V VRVAGYSAFFVELCKDVQDEII S RT M L EHF 789
Name
Accession
Description
Interval
E-value
choline_CutC
TIGR04394 choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and ...
60-848
0e+00
choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines]
Pssm-ID: 275187 [Multi-domain]
Cd Length: 789
Bit Score: 1568.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 60 I T P RL QA LK NQ YLK AQ P T I SLL RA TNL T R I S KEN E GMPK AI LR GT AF KEF C KI AP V VIQD N EL L VGAP N G GA R F GAFSPD 139
Cdd:TIGR04394 1 P T E RL VR LK EN YLK QV P S I TIY RA RAI T E I A KEN P GMPK IL LR AK AF RKC C ET AP L VIQD D EL I VGAP C G AP R A GAFSPD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 140 I S WRWLRDE I DT VS TRPQDP YAL SEEDKK VL REEIFP Y WEG R S V DE A CE T QYREAG A WELSGESFVSDCSYHA CS GGGDS 219
Cdd:TIGR04394 81 I A WRWLRDE L DT IG TRPQDP FYI SEEDKK IM REEIFP F WEG K S L DE Y CE D QYREAG V WELSGESFVSDCSYHA VN GGGDS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 220 NPGYDV VG M R KGMLDI K AEA EA HL SK L D Y G NP D D LE KIYFYK AQ I L T A EGVMIYAKR M SE H AAELAAKE LN PKRKAELE M 299
Cdd:TIGR04394 161 NPGYDV IL M K KGMLDI Q AEA KE HL AE L S Y E NP E D ID KIYFYK SV I D T T EGVMIYAKR L SE Y AAELAAKE QD PKRKAELE K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 300 I SR VNA N VPAHKP E TFWEA M Q Y V V T IQH LL LC EENQTG L SIGRVDQYMYP L YK R DIEAGRM ND Y Q AFELAGCM F IKMSEM 379
Cdd:TIGR04394 241 I AE VNA R VPAHKP R TFWEA I Q S V W T VES LL VV EENQTG M SIGRVDQYMYP F YK A DIEAGRM TE Y E AFELAGCM L IKMSEM 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 380 MWLTSEG S SKFFAGYQPFVNMCVGGVTREG R DATNDLTYLLMDA I RHVKVYQP T LA T RI N NKSP R KYLKKIVDVVRAG I G 459
Cdd:TIGR04394 321 MWLTSEG G SKFFAGYQPFVNMCVGGVTREG G DATNDLTYLLMDA V RHVKVYQP S LA C RI H NKSP Q KYLKKIVDVVRAG M G 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 460 FPACHFDD S HIKMMLAKGVS M EDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPI L IE TT LNHG I PLWYGK P V T PD M G S L D 539
Cdd:TIGR04394 401 FPACHFDD A HIKMMLAKGVS I EDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPI C IE LV LNHG V PLWYGK Q V C PD T G D L S 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 540 Q YK T F E Q F E AAVKE T IKY V TKW TS V M TVISQRV Q R E LAP A PLMS M MYEG T ME N G RG V KS GGAMYNFGPGVVWSGLA N YAD 619
Cdd:TIGR04394 481 Q FD T Y E K F D AAVKE Q IKY I TKW SA V A TVISQRV H R D LAP K PLMS L MYEG C ME K G KD V SA GGAMYNFGPGVVWSGLA T YAD 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 620 SMAAIKKLV FE DKKYTL DE LN K AL I A D FEGY D QIRADCL A APKYGNDDDY V D YF A S D IIE FTE E EHRKYKTLYS V LSHGT 699
Cdd:TIGR04394 561 SMAAIKKLV YD DKKYTL EQ LN E AL K A N FEGY E QIRADCL D APKYGNDDDY A D LI A A D LVN FTE R EHRKYKTLYS H LSHGT 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 700 LSISNNTP L GQ I TGASA S GR R AWTPLSDGISP DH G M D T KGPTAIIKSVSKMAN EN MNIGMVHNFK I M A GLLDTP Q GE ES L 779
Cdd:TIGR04394 641 LSISNNTP F GQ L TGASA N GR L AWTPLSDGISP TQ G A D F KGPTAIIKSVSKMAN DS MNIGMVHNFK L M S GLLDTP E GE NG L 720
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636996776 780 ITLLRTASILGNGEMQFNYLDN AI LLDAQQHPEKYRDL I VRVAGYSAFFVELCKDVQDEII A RT V L TRI 848
Cdd:TIGR04394 721 ITLLRTASILGNGEMQFNYLDN ET LLDAQQHPEKYRDL V VRVAGYSAFFVELCKDVQDEII S RT M L EHF 789
PFL2_DhaB_BssA
cd01677 Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 ...
61-843
0e+00
Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.
Pssm-ID: 153086 [Multi-domain]
Cd Length: 781
Bit Score: 1045.71
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 61 T P R LQA LK NQY L K A Q P T IS LL RA TNL T RIS KE N EG M P KA I L R GT A F K EFCKI A PVV IQD N EL L VG APN G GA R FGAFS P DI 140
Cdd:cd01677 1 T E R IKR LK AKI L T A K P S IS IE RA RLY T ESY KE T EG K P VI I R R AK A L K HILEN A TIY IQD D EL I VG NRG G KP R AVPVF P EL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 141 S WR W LR DE I D TVST RP Q DP YAL SE e DKK VLR EEIFPYW E G RSVDEA C ETQYR E AGAWELSGES F VSDCSYH ac SG G G DSN 220
Cdd:cd01677 81 S VH W VE DE L D DLPK RP G DP FVI SE - DKK EYL EEIFPYW K G KTLRDR C FKYFP E ETLIAMAAGV F TEFMYFF -- SG P G HVA 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 221 PG Y DV V GMRKGMLD I K a EA EAHLSK LD YGN P D D LE KIYFY K A Q I LTA E G V MI YAKR MS E H A A ELAAKE LN PKRKAEL EM I 300
Cdd:cd01677 158 VD Y PK V LEKGLDGL I E - EA KEAIEA LD LTG P E D ID KIYFY Q A M I IVC E A V IT YAKR YA E L A K ELAAKE TD PKRKAEL LE I 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 301 SRVNAN VPAH K P E TFWEA M Q YVVT I QHL L LC E E N QTGL S I GR V DQY M YP L YK R DIE A GR MNDYQ A F EL AG C MF IK MS E MM 380
Cdd:cd01677 237 AEICRR VPAH P P R TFWEA L Q SFWF I HLI L QI E S N GHSI S P GR F DQY L YP F YK Q DIE E GR LTREG A I EL LE C LW IK IN E IN 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 381 WLT S EG S S K F FAGY QP F V N MCV GG V T RE G R DATN D L T YL LMD A I R H V KVY QP T L AT R INN KSP R K Y LKK IVD V V R A G I G F 460
Cdd:cd01677 317 KVR S GA S A K Y FAGY NT F Q N LTI GG Q T ED G S DATN E L S YL ILE A T R R V RLP QP S L TV R YHA KSP D K F LKK AAE V I R L G L G Y 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 461 PA CHF D DSH I KMM L A KGVS M EDARDY C L M GCVE PQKS GR L Y Q WT S T A Y TQWPILI E T TLN H G IPLWY GK P V T P DM G SLDQ 540
Cdd:cd01677 397 PA FFN D EVV I PAL L R KGVS L EDARDY G L I GCVE TGAP GR K Y R WT G T G Y INLAKVL E I TLN N G KDPRS GK Q V G P ET G DATD 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 541 Y KTFE QFEA A V K ETIKYVT K WTSVMTV IS QRVQR E L APAP LM S MMYEGTM E N G RGVKS GGA M YNFG p G VVWS G L A NYA DS 620
Cdd:cd01677 477 F KTFE ELWE A F K KQLRHFI K LSVRANN IS DIAHA E V APAP FL S ALVDDCI E K G KDINA GGA R YNFG - G IQGV G I A TLG DS 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 621 M AAIKKLVFE D KK Y T LD EL NK AL I A D F - EGY DQI R ADCLA APKYGNDDDY V D YF A SDII E FTEE E HR KY K - TLYSVLSH G 698
Cdd:cd01677 556 L AAIKKLVFE E KK L T ME EL LE AL K A N F a EGY EER R RLLNN APKYGNDDDY A D NI A RRVY E WYCK E VE KY Q n PRGGKFYP G 635
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 699 T L S I S N N T P L G QI TGA SAS GR R A W TPLSDG I SP DH G M D T KGPTA I IKSVSK MANE N MNI G MVH N F K IMAGL L DTPQ G EES 778
Cdd:cd01677 636 T Y S V S A N V P F G SV TGA TPD GR L A G TPLSDG V SP SQ G T D K KGPTA V IKSVSK LDHF N ISG G TLL N Q K FSPST L EGEE G LKK 715
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636996776 779 L IT L L RT ASI LG NGEM QFN YLDNAI L L DAQ Q HPEKYRDLIVRVAGYSA F FVEL C K D VQDEIIART 843
Cdd:cd01677 716 L AA L I RT YFD LG GHHI QFN VVSAET L R DAQ K HPEKYRDLIVRVAGYSA Y FVEL S K E VQDEIIART 780
PflD
COG1882 Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of ...
59-847
0e+00
Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 441486 [Multi-domain]
Cd Length: 789
Bit Score: 1006.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 59 G I T P R LQA L KNQY L K A Q P T I SLL RA TNL T RIS KE N EG M P KA I L R GT AF KEFCKIA P VV I Q D N EL L VG APNGGA R FGAFS P 138
Cdd:COG1882 6 G P T E R TKR L REKL L E A K P L I DIE RA RLF T ESY KE T EG L P VI I R R AK AF SHILEHK P IY I K D D EL I VG LQTDKP R KRPIF P 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 139 DISW RW LR DE I D TVS TRPQD PYAL S E EDK KVL RE e I F PYW E G RSVDEACETQ Y R E A ga WELSGESFVSDCSYH A c S G G G D 218
Cdd:COG1882 86 EGGI RW VE DE L D ALP TRPQD GFEI S P EDK EIF RE - I A PYW K G KTHNDGVFDA Y P E E -- IRKARKAGIITGLPD A - Y G R G H 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 219 SNPG Y DV V g MRK G MLDIKA EA EAH L SK LD YGN P D D L EKI Y FYKA Q I LTA E G V MIY A K R MS E H A A ELA A KE LN PKRKAEL E 298
Cdd:COG1882 162 IIGD Y RR V - LLY G LDGLIE EA KEK L AE LD LTD P E D I EKI D FYKA M I IVC E A V IRL A E R YA E L A R ELA E KE TD PKRKAEL L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 299 M I SRVNAN VPA HKPE TFWEA M Q Y V VTIQHLLLC E E N QTGL S I GR V DQY M YP L Y K RD I E A GR MNDYQ A F EL AG C MF IK MS E 378
Cdd:COG1882 241 E I AEICGF VPA NPAR TFWEA V Q W V WFVYLAAIK E Q N GAAM S L GR F DQY L YP Y Y E RD L E E GR LTEEE A Q EL LD C FW IK LR E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 379 MMW L TSEGSSKF FAGY QPF V NMCV GG V T RE GRDA T N D L T YL LMDAI R HVKVYQ P T L AT R INN K S P RKY LKK IVD V VRA G I 458
Cdd:COG1882 321 VRF L RTPEYAEL FAGY PTW V TLTI GG M T PD GRDA V N E L S YL ILETL R NLPLPE P N L TV R WSE K L P EGF LKK AAE V ISI G T 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 459 G F P ACHF DD SH I K M M L A KGV SM EDARDY CLM GCVEP QKS G RLY Q WTSTAYTQWPILI E TT LN H G IPLWY GK P V T P DM G SL 538
Cdd:COG1882 401 G S P QYEN DD LM I P M L L N KGV TL EDARDY GIA GCVEP MVP G KQM Q FFGAGRINLAKAL E YA LN N G VDEKT GK Q V G P ET G DP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 539 DQYK T FEQFEA A V K ETIK Y VTKWTSVMTV I SQRVQREL AP A P LM S MMYEGTM E N G RGVKS GGA M YNFG p GVVWS GL ANY A 618
Cdd:COG1882 481 TDFL T YDEVME A F K KQLD Y LADLYVNALN I IHYMHDKY AP E P FL S ALHDDCI E R G KDLNE GGA R YNFG - AIGIA GL SVV A 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 619 DS MA AIKKLVF ED KK Y T L DEL NK AL I A D FEGY DQI R ADC L A APKYGNDDDYVD YF A SDII E FTEE E H RKYKT LY - SVLSH 697
Cdd:COG1882 560 DS LS AIKKLVF DK KK V T M DEL LE AL A A N FEGY EEL R QLL L N APKYGNDDDYVD EI A VELV E TFMD E I RKYKT YR g GTYTL 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 698 GT L S I SN N T P L G QI TGA SAS GR R A WT PL S DG I SP D HG M D TK GPTA II KSV S K MAN E NMNI G MVH N F K IMAGL L DTPQ G E E 777
Cdd:COG1882 640 SI L T I TS N V P Y G KK TGA TPD GR K A GE PL A DG A SP M HG R D KN GPTA VL KSV A K LPY E KATD G ILL N Q K FSPSA L GGEE G I E 719
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 778 S L IT LLRT ASI LG NGEM QFN YL D NAI LLDAQ Q HPEKY R DL I VRVAGYSA F FVEL C K DV QD E IIART VLTR 847
Cdd:COG1882 720 N L VS LLRT YFD LG GHHI QFN VV D RET LLDAQ K HPEKY P DL T VRVAGYSA Y FVEL S K EQ QD D IIART EHEF 789
PFL-like
pfam02901 Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline ...
61-709
0e+00
Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.
Pssm-ID: 427048
Cd Length: 647
Bit Score: 780.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 61 TP R LQA LK NQ Y L -- KAQ P TI S LL RA TN LT RIS KE N EG M - P KA I L R GT A F K EFCKIA P VV I Q D N EL L VG APNGGA R FG A FS 137
Cdd:pfam02901 2 WE R IDV LK EN Y T ly TGD P SL S WE RA RL LT ESY KE T EG V l P VD I R R AK A L K KILSHL P GY I R D D EL I VG LQTDKP R KR A IY 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 138 P DISW RW LR DE I D TVS TRPQD PYAL SEEDKK VL RE e IFPYW E G RSVD E ACETQ Y REA ga WELSG ES FVSDCSYH A c S G G G 217
Cdd:pfam02901 82 P EGGI RW VE DE L D YLN TRPQD GFEI SEEDKK IF RE - IFPYW K G KTHN E GVFDA Y TPE -- MKAAR ES GIFTGLPD A - Y G R G 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 218 DSNPG Y DV V g MRK G MLDIKA E A E AH L S KLD y GN P D D L EKI Y FYKA Q I LTAEG V MI YA K R MSEH A A ELA AK E LN PKRKAEL 297
Cdd:pfam02901 158 HIIGD Y RR V - LLY G LDGLIE E K E EK L A KLD - TD P E D I EKI E FYKA M I ISCDA V IE YA E R YARL A E ELA EQ E TD PKRKAEL 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 298 EM I SRVNAN VPA HKP ETF W EA M Q YVVTIQHLLLC E E N QTGL S I GR V DQY M YP L Y K RD I E A GR MNDYQ A F EL AG C MF IK MS 377
Cdd:pfam02901 236 LE I AEICGR VPA RPA ETF Q EA I Q WFWFVYLAAVK E Q N GAAM S L GR L DQY L YP Y Y E RD L E E GR LTEEE A Q EL ID C FW IK LR 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 378 E MMW L TSEGSS K F FAGY Q PF V N MCV GG VT R E GRDA T N D L T YL LMD A IRHVKVYQ P T L AT R INN K S P RKY LKK IVD V V R A G 457
Cdd:pfam02901 316 E VRF L RTPEYN K L FAGY D PF Q N LTI GG QG R D GRDA V N K L S YL ILE A LDNLPLPE P N L TV R WSK K L P EEF LKK AAE V S R K G 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 458 I G F P ACHF DD SH I KMM L AK GVS M EDARDY CLM GCVEP Q K S G RLY Q WT s T A YTQWPILI E TT LN H G IPLWY GK P V T P DM G S 537
Cdd:pfam02901 396 T G S P QYEN DD VM I PAL L NR GVS L EDARDY GIA GCVEP M K P G KEM Q FF - G A RINLAKAL E YA LN G G RDELT GK Q V G P KT G P 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 538 LDQYKT FE QFEA A V K ETIK Y VTKWTSVMTV I SQRVQREL AP A P LM S MMYEGTM E N G RG V KS GGA M YNF g P G VVWS GLAN Y 617
Cdd:pfam02901 475 VTEFLS FE EVME A F K KQLD Y LADLYVNALN I IHYMHDKY AP E P FL S ALHDDCI E R G KD V GI GGA R YNF - S G PQGA GLAN V 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 618 ADS MA AIKKLVF E DK K YTL D EL NK AL I ADFEG YDQI R A D C L A - APKYGNDDD Y VD YF A SDII E FTEE E H RKYK TLY - SVL 695
Cdd:pfam02901 554 ADS LS AIKKLVF D DK V YTL R EL ED AL A ADFEG EEEL R Q D L L N d APKYGNDDD R VD DI A VEVV E TFMD E V RKYK NYR g GKF 633
650
....*....|....
gi 636996776 696 SHGT L S I SN N T P L G 709
Cdd:pfam02901 634 TPSL L T I TS N V P Y G 647
pflD
PRK09983 putative formate acetyltransferase 2; Provisional
60-843
4.26e-162
putative formate acetyltransferase 2; Provisional
Pssm-ID: 182181 [Multi-domain]
Cd Length: 765
Bit Score: 490.87
E-value: 4.26e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 60 I T P R LQA LK NQYLKAQPT ISL L RA TNL T RISKEN EG M P KAIL R GT A FKEFCKIAPVV I Q D N EL LV G APNGGA R F G AF SP D 139
Cdd:PRK09983 1 M T N R ISR LK TALFANTRE ISL E RA LLY T ASHRQT EG E P VILR R AK A TAYILEHVEIS I R D E EL IA G NRTVKP R A G IM SP E 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 140 ISWR WL RD E I D TVS TRPQD PY A L SEEDK KVL REE I FPYWE G RS VDEACET Q YREAGAWEL S GES F VSD csy HACS G G G DS 219
Cdd:PRK09983 81 MDPY WL LK E L D QFP TRPQD RF A I SEEDK RIY REE L FPYWE K RS MKDFING Q MTDEVKAAT S TQI F SIN --- QTDK G Q G HI 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 220 NPG Y DVV g MRK G MLDIK A EAEA H LSK ldyg N P DD leki Y FY K A QI L TA E GVMIYAK R MS E H A AEL AA KELNPK R KA EL EM 299
Cdd:PRK09983 158 IID Y PRL - LNH G LGELV A QMQQ H CQQ ---- Q P EN ---- H FY Q A AL L LL E ASQKHIL R YA E L A ETM AA NCTDAQ R RE EL LT 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 300 I SRVNANVPA HKP E TFW E A M Q YVVTIQHL L LC E E N QTG LS I GR V DQYM Y P L Y KRDIEA G rmn DYQ AF -- EL AGCMFI K MS 377
Cdd:PRK09983 229 I AEISRHNAQ HKP Q TFW Q A C Q LFWYMNII L QY E S N ASS LS L GR F DQYM L P F Y QASLTQ G --- EDP AF lk EL LESLWV K CN 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 378 EMMW L T S EG S SKF FAG YQPFVNMCV GG V T RE GR D A T N D L TY L LM DA IRH V KVY QP T L AT R I N NKSPRKY L K K IVDVV R A G 457
Cdd:PRK09983 306 DIVL L R S TS S ARY FAG FPTGYTALL GG L T EN GR S A V N V L SF L CL DA YQS V QLP QP N L GV R T N ALIDTPF L M K TAETI R L G 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 458 I G F P ACHF D DSHIKMM L AK GVS M EDARDY CLM GCVE PQKS GR L Y QWTST A YTQWPILI E TT L -- N H G iplwygkpvtpdm 535
Cdd:PRK09983 386 T G I P QIFN D EVVVPAF L NR GVS L EDARDY SVV GCVE LSIP GR T Y GLHDI A MFNLLKVM E IC L he N E G ------------- 452
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 536 gsl DQYK T F E QFEAAVKET I KYVTKWTSVMTV I SQRVQ R EL AP A PL M S MMYEGTM E N GR GVKS GGA M YNF G p GV VWS G L A 615
Cdd:PRK09983 453 --- NAAL T Y E GLLEQIRAK I SHYITLMVEGSN I CDIGH R DW AP V PL L S SFISDCL E K GR DITD GGA R YNF S - GV QGI G I A 528
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 616 N YA DS MA A I K KL VF EDKKYTL DEL NKA L I A D F -- EGYDQI RA DCLAA - P KYGND D D Y VD YFASDIIEFTEE E HR KY KTLY 692
Cdd:PRK09983 529 N LS DS LH A L K GM VF DQQRLSF DEL LSV L K A N F at PEGEKV RA RLINR f E KYGND I D E VD NISAELLRHYCK E VE KY QNPR 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 693 - SVLSH G TLSI S NNT PLG QIT GA SAS GR R A WTP L S D - G I SP DH G M D TK GPTA II KSVSK MA N ENMNI G MVH N F K IMAGL L 770
Cdd:PRK09983 609 g GYFTP G SYTV S AHV PLG SVV GA TPD GR F A GEQ L A D g G L SP ML G Q D AQ GPTA VL KSVSK LD N TLLSN G TLL N V K FTPAT L 688
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636996776 771 DTPQ G EES L ITL LR TASI L GNGEM QFN YLDNAI L LD AQQ H P EK Y RD L I VRVAGYSAFFVEL C K DV QD E II A RT 843
Cdd:PRK09983 689 EGEA G LRK L ADF LR AFTQ L KLQHI QFN VVNADT L RE AQQ R P QD Y AG L V VRVAGYSAFFVEL S K EI QD D II R RT 761
Name
Accession
Description
Interval
E-value
choline_CutC
TIGR04394 choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and ...
60-848
0e+00
choline trimethylamine-lyase; Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. [Energy metabolism, Amino acids and amines]
Pssm-ID: 275187 [Multi-domain]
Cd Length: 789
Bit Score: 1568.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 60 I T P RL QA LK NQ YLK AQ P T I SLL RA TNL T R I S KEN E GMPK AI LR GT AF KEF C KI AP V VIQD N EL L VGAP N G GA R F GAFSPD 139
Cdd:TIGR04394 1 P T E RL VR LK EN YLK QV P S I TIY RA RAI T E I A KEN P GMPK IL LR AK AF RKC C ET AP L VIQD D EL I VGAP C G AP R A GAFSPD 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 140 I S WRWLRDE I DT VS TRPQDP YAL SEEDKK VL REEIFP Y WEG R S V DE A CE T QYREAG A WELSGESFVSDCSYHA CS GGGDS 219
Cdd:TIGR04394 81 I A WRWLRDE L DT IG TRPQDP FYI SEEDKK IM REEIFP F WEG K S L DE Y CE D QYREAG V WELSGESFVSDCSYHA VN GGGDS 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 220 NPGYDV VG M R KGMLDI K AEA EA HL SK L D Y G NP D D LE KIYFYK AQ I L T A EGVMIYAKR M SE H AAELAAKE LN PKRKAELE M 299
Cdd:TIGR04394 161 NPGYDV IL M K KGMLDI Q AEA KE HL AE L S Y E NP E D ID KIYFYK SV I D T T EGVMIYAKR L SE Y AAELAAKE QD PKRKAELE K 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 300 I SR VNA N VPAHKP E TFWEA M Q Y V V T IQH LL LC EENQTG L SIGRVDQYMYP L YK R DIEAGRM ND Y Q AFELAGCM F IKMSEM 379
Cdd:TIGR04394 241 I AE VNA R VPAHKP R TFWEA I Q S V W T VES LL VV EENQTG M SIGRVDQYMYP F YK A DIEAGRM TE Y E AFELAGCM L IKMSEM 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 380 MWLTSEG S SKFFAGYQPFVNMCVGGVTREG R DATNDLTYLLMDA I RHVKVYQP T LA T RI N NKSP R KYLKKIVDVVRAG I G 459
Cdd:TIGR04394 321 MWLTSEG G SKFFAGYQPFVNMCVGGVTREG G DATNDLTYLLMDA V RHVKVYQP S LA C RI H NKSP Q KYLKKIVDVVRAG M G 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 460 FPACHFDD S HIKMMLAKGVS M EDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPI L IE TT LNHG I PLWYGK P V T PD M G S L D 539
Cdd:TIGR04394 401 FPACHFDD A HIKMMLAKGVS I EDARDYCLMGCVEPQKSGRLYQWTSTAYTQWPI C IE LV LNHG V PLWYGK Q V C PD T G D L S 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 540 Q YK T F E Q F E AAVKE T IKY V TKW TS V M TVISQRV Q R E LAP A PLMS M MYEG T ME N G RG V KS GGAMYNFGPGVVWSGLA N YAD 619
Cdd:TIGR04394 481 Q FD T Y E K F D AAVKE Q IKY I TKW SA V A TVISQRV H R D LAP K PLMS L MYEG C ME K G KD V SA GGAMYNFGPGVVWSGLA T YAD 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 620 SMAAIKKLV FE DKKYTL DE LN K AL I A D FEGY D QIRADCL A APKYGNDDDY V D YF A S D IIE FTE E EHRKYKTLYS V LSHGT 699
Cdd:TIGR04394 561 SMAAIKKLV YD DKKYTL EQ LN E AL K A N FEGY E QIRADCL D APKYGNDDDY A D LI A A D LVN FTE R EHRKYKTLYS H LSHGT 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 700 LSISNNTP L GQ I TGASA S GR R AWTPLSDGISP DH G M D T KGPTAIIKSVSKMAN EN MNIGMVHNFK I M A GLLDTP Q GE ES L 779
Cdd:TIGR04394 641 LSISNNTP F GQ L TGASA N GR L AWTPLSDGISP TQ G A D F KGPTAIIKSVSKMAN DS MNIGMVHNFK L M S GLLDTP E GE NG L 720
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 636996776 780 ITLLRTASILGNGEMQFNYLDN AI LLDAQQHPEKYRDL I VRVAGYSAFFVELCKDVQDEII A RT V L TRI 848
Cdd:TIGR04394 721 ITLLRTASILGNGEMQFNYLDN ET LLDAQQHPEKYRDL V VRVAGYSAFFVELCKDVQDEII S RT M L EHF 789
PFL2_DhaB_BssA
cd01677 Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 ...
61-843
0e+00
Pyruvate formate lyase 2 and related enzymes; This family includes pyruvate formate lyase 2 (PFL2), B12-independent glycerol dehydratase (DhaB) and the alpha subunit of benzylsuccinate synthase (BssA), all of which have a highly conserved ten-stranded alpha/beta barrel domain, which is similar to those of PFL1 (pyruvate formate lyase 1) and RNR (ribonucleotide reductase). Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. DhaB catalyzes the first step in the conversion of glycerol to 1,3-propanediol while BssA catalyzes the first step in the anaerobic mineralization of both toluene and m-xylene.
Pssm-ID: 153086 [Multi-domain]
Cd Length: 781
Bit Score: 1045.71
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 61 T P R LQA LK NQY L K A Q P T IS LL RA TNL T RIS KE N EG M P KA I L R GT A F K EFCKI A PVV IQD N EL L VG APN G GA R FGAFS P DI 140
Cdd:cd01677 1 T E R IKR LK AKI L T A K P S IS IE RA RLY T ESY KE T EG K P VI I R R AK A L K HILEN A TIY IQD D EL I VG NRG G KP R AVPVF P EL 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 141 S WR W LR DE I D TVST RP Q DP YAL SE e DKK VLR EEIFPYW E G RSVDEA C ETQYR E AGAWELSGES F VSDCSYH ac SG G G DSN 220
Cdd:cd01677 81 S VH W VE DE L D DLPK RP G DP FVI SE - DKK EYL EEIFPYW K G KTLRDR C FKYFP E ETLIAMAAGV F TEFMYFF -- SG P G HVA 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 221 PG Y DV V GMRKGMLD I K a EA EAHLSK LD YGN P D D LE KIYFY K A Q I LTA E G V MI YAKR MS E H A A ELAAKE LN PKRKAEL EM I 300
Cdd:cd01677 158 VD Y PK V LEKGLDGL I E - EA KEAIEA LD LTG P E D ID KIYFY Q A M I IVC E A V IT YAKR YA E L A K ELAAKE TD PKRKAEL LE I 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 301 SRVNAN VPAH K P E TFWEA M Q YVVT I QHL L LC E E N QTGL S I GR V DQY M YP L YK R DIE A GR MNDYQ A F EL AG C MF IK MS E MM 380
Cdd:cd01677 237 AEICRR VPAH P P R TFWEA L Q SFWF I HLI L QI E S N GHSI S P GR F DQY L YP F YK Q DIE E GR LTREG A I EL LE C LW IK IN E IN 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 381 WLT S EG S S K F FAGY QP F V N MCV GG V T RE G R DATN D L T YL LMD A I R H V KVY QP T L AT R INN KSP R K Y LKK IVD V V R A G I G F 460
Cdd:cd01677 317 KVR S GA S A K Y FAGY NT F Q N LTI GG Q T ED G S DATN E L S YL ILE A T R R V RLP QP S L TV R YHA KSP D K F LKK AAE V I R L G L G Y 396
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 461 PA CHF D DSH I KMM L A KGVS M EDARDY C L M GCVE PQKS GR L Y Q WT S T A Y TQWPILI E T TLN H G IPLWY GK P V T P DM G SLDQ 540
Cdd:cd01677 397 PA FFN D EVV I PAL L R KGVS L EDARDY G L I GCVE TGAP GR K Y R WT G T G Y INLAKVL E I TLN N G KDPRS GK Q V G P ET G DATD 476
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 541 Y KTFE QFEA A V K ETIKYVT K WTSVMTV IS QRVQR E L APAP LM S MMYEGTM E N G RGVKS GGA M YNFG p G VVWS G L A NYA DS 620
Cdd:cd01677 477 F KTFE ELWE A F K KQLRHFI K LSVRANN IS DIAHA E V APAP FL S ALVDDCI E K G KDINA GGA R YNFG - G IQGV G I A TLG DS 555
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 621 M AAIKKLVFE D KK Y T LD EL NK AL I A D F - EGY DQI R ADCLA APKYGNDDDY V D YF A SDII E FTEE E HR KY K - TLYSVLSH G 698
Cdd:cd01677 556 L AAIKKLVFE E KK L T ME EL LE AL K A N F a EGY EER R RLLNN APKYGNDDDY A D NI A RRVY E WYCK E VE KY Q n PRGGKFYP G 635
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 699 T L S I S N N T P L G QI TGA SAS GR R A W TPLSDG I SP DH G M D T KGPTA I IKSVSK MANE N MNI G MVH N F K IMAGL L DTPQ G EES 778
Cdd:cd01677 636 T Y S V S A N V P F G SV TGA TPD GR L A G TPLSDG V SP SQ G T D K KGPTA V IKSVSK LDHF N ISG G TLL N Q K FSPST L EGEE G LKK 715
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 636996776 779 L IT L L RT ASI LG NGEM QFN YLDNAI L L DAQ Q HPEKYRDLIVRVAGYSA F FVEL C K D VQDEIIART 843
Cdd:cd01677 716 L AA L I RT YFD LG GHHI QFN VVSAET L R DAQ K HPEKYRDLIVRVAGYSA Y FVEL S K E VQDEIIART 780
PflD
COG1882 Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of ...
59-847
0e+00
Pyruvate-formate lyase [Energy production and conversion]; Pyruvate-formate lyase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 441486 [Multi-domain]
Cd Length: 789
Bit Score: 1006.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 59 G I T P R LQA L KNQY L K A Q P T I SLL RA TNL T RIS KE N EG M P KA I L R GT AF KEFCKIA P VV I Q D N EL L VG APNGGA R FGAFS P 138
Cdd:COG1882 6 G P T E R TKR L REKL L E A K P L I DIE RA RLF T ESY KE T EG L P VI I R R AK AF SHILEHK P IY I K D D EL I VG LQTDKP R KRPIF P 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 139 DISW RW LR DE I D TVS TRPQD PYAL S E EDK KVL RE e I F PYW E G RSVDEACETQ Y R E A ga WELSGESFVSDCSYH A c S G G G D 218
Cdd:COG1882 86 EGGI RW VE DE L D ALP TRPQD GFEI S P EDK EIF RE - I A PYW K G KTHNDGVFDA Y P E E -- IRKARKAGIITGLPD A - Y G R G H 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 219 SNPG Y DV V g MRK G MLDIKA EA EAH L SK LD YGN P D D L EKI Y FYKA Q I LTA E G V MIY A K R MS E H A A ELA A KE LN PKRKAEL E 298
Cdd:COG1882 162 IIGD Y RR V - LLY G LDGLIE EA KEK L AE LD LTD P E D I EKI D FYKA M I IVC E A V IRL A E R YA E L A R ELA E KE TD PKRKAEL L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 299 M I SRVNAN VPA HKPE TFWEA M Q Y V VTIQHLLLC E E N QTGL S I GR V DQY M YP L Y K RD I E A GR MNDYQ A F EL AG C MF IK MS E 378
Cdd:COG1882 241 E I AEICGF VPA NPAR TFWEA V Q W V WFVYLAAIK E Q N GAAM S L GR F DQY L YP Y Y E RD L E E GR LTEEE A Q EL LD C FW IK LR E 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 379 MMW L TSEGSSKF FAGY QPF V NMCV GG V T RE GRDA T N D L T YL LMDAI R HVKVYQ P T L AT R INN K S P RKY LKK IVD V VRA G I 458
Cdd:COG1882 321 VRF L RTPEYAEL FAGY PTW V TLTI GG M T PD GRDA V N E L S YL ILETL R NLPLPE P N L TV R WSE K L P EGF LKK AAE V ISI G T 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 459 G F P ACHF DD SH I K M M L A KGV SM EDARDY CLM GCVEP QKS G RLY Q WTSTAYTQWPILI E TT LN H G IPLWY GK P V T P DM G SL 538
Cdd:COG1882 401 G S P QYEN DD LM I P M L L N KGV TL EDARDY GIA GCVEP MVP G KQM Q FFGAGRINLAKAL E YA LN N G VDEKT GK Q V G P ET G DP 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 539 DQYK T FEQFEA A V K ETIK Y VTKWTSVMTV I SQRVQREL AP A P LM S MMYEGTM E N G RGVKS GGA M YNFG p GVVWS GL ANY A 618
Cdd:COG1882 481 TDFL T YDEVME A F K KQLD Y LADLYVNALN I IHYMHDKY AP E P FL S ALHDDCI E R G KDLNE GGA R YNFG - AIGIA GL SVV A 559
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 619 DS MA AIKKLVF ED KK Y T L DEL NK AL I A D FEGY DQI R ADC L A APKYGNDDDYVD YF A SDII E FTEE E H RKYKT LY - SVLSH 697
Cdd:COG1882 560 DS LS AIKKLVF DK KK V T M DEL LE AL A A N FEGY EEL R QLL L N APKYGNDDDYVD EI A VELV E TFMD E I RKYKT YR g GTYTL 639
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 698 GT L S I SN N T P L G QI TGA SAS GR R A WT PL S DG I SP D HG M D TK GPTA II KSV S K MAN E NMNI G MVH N F K IMAGL L DTPQ G E E 777
Cdd:COG1882 640 SI L T I TS N V P Y G KK TGA TPD GR K A GE PL A DG A SP M HG R D KN GPTA VL KSV A K LPY E KATD G ILL N Q K FSPSA L GGEE G I E 719
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 778 S L IT LLRT ASI LG NGEM QFN YL D NAI LLDAQ Q HPEKY R DL I VRVAGYSA F FVEL C K DV QD E IIART VLTR 847
Cdd:COG1882 720 N L VS LLRT YFD LG GHHI QFN VV D RET LLDAQ K HPEKY P DL T VRVAGYSA Y FVEL S K EQ QD D IIART EHEF 789
PFL-like
pfam02901 Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline ...
61-709
0e+00
Pyruvate formate lyase-like; This family of enzymes includes pyruvate formate lyase, choline trimethylamine lyase, glycerol dehydratase, 4-hydroxyphenylacetate decarboxylase, and benzylsuccinate synthase.
Pssm-ID: 427048
Cd Length: 647
Bit Score: 780.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 61 TP R LQA LK NQ Y L -- KAQ P TI S LL RA TN LT RIS KE N EG M - P KA I L R GT A F K EFCKIA P VV I Q D N EL L VG APNGGA R FG A FS 137
Cdd:pfam02901 2 WE R IDV LK EN Y T ly TGD P SL S WE RA RL LT ESY KE T EG V l P VD I R R AK A L K KILSHL P GY I R D D EL I VG LQTDKP R KR A IY 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 138 P DISW RW LR DE I D TVS TRPQD PYAL SEEDKK VL RE e IFPYW E G RSVD E ACETQ Y REA ga WELSG ES FVSDCSYH A c S G G G 217
Cdd:pfam02901 82 P EGGI RW VE DE L D YLN TRPQD GFEI SEEDKK IF RE - IFPYW K G KTHN E GVFDA Y TPE -- MKAAR ES GIFTGLPD A - Y G R G 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 218 DSNPG Y DV V g MRK G MLDIKA E A E AH L S KLD y GN P D D L EKI Y FYKA Q I LTAEG V MI YA K R MSEH A A ELA AK E LN PKRKAEL 297
Cdd:pfam02901 158 HIIGD Y RR V - LLY G LDGLIE E K E EK L A KLD - TD P E D I EKI E FYKA M I ISCDA V IE YA E R YARL A E ELA EQ E TD PKRKAEL 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 298 EM I SRVNAN VPA HKP ETF W EA M Q YVVTIQHLLLC E E N QTGL S I GR V DQY M YP L Y K RD I E A GR MNDYQ A F EL AG C MF IK MS 377
Cdd:pfam02901 236 LE I AEICGR VPA RPA ETF Q EA I Q WFWFVYLAAVK E Q N GAAM S L GR L DQY L YP Y Y E RD L E E GR LTEEE A Q EL ID C FW IK LR 315
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 378 E MMW L TSEGSS K F FAGY Q PF V N MCV GG VT R E GRDA T N D L T YL LMD A IRHVKVYQ P T L AT R INN K S P RKY LKK IVD V V R A G 457
Cdd:pfam02901 316 E VRF L RTPEYN K L FAGY D PF Q N LTI GG QG R D GRDA V N K L S YL ILE A LDNLPLPE P N L TV R WSK K L P EEF LKK AAE V S R K G 395
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 458 I G F P ACHF DD SH I KMM L AK GVS M EDARDY CLM GCVEP Q K S G RLY Q WT s T A YTQWPILI E TT LN H G IPLWY GK P V T P DM G S 537
Cdd:pfam02901 396 T G S P QYEN DD VM I PAL L NR GVS L EDARDY GIA GCVEP M K P G KEM Q FF - G A RINLAKAL E YA LN G G RDELT GK Q V G P KT G P 474
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 538 LDQYKT FE QFEA A V K ETIK Y VTKWTSVMTV I SQRVQREL AP A P LM S MMYEGTM E N G RG V KS GGA M YNF g P G VVWS GLAN Y 617
Cdd:pfam02901 475 VTEFLS FE EVME A F K KQLD Y LADLYVNALN I IHYMHDKY AP E P FL S ALHDDCI E R G KD V GI GGA R YNF - S G PQGA GLAN V 553
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 618 ADS MA AIKKLVF E DK K YTL D EL NK AL I ADFEG YDQI R A D C L A - APKYGNDDD Y VD YF A SDII E FTEE E H RKYK TLY - SVL 695
Cdd:pfam02901 554 ADS LS AIKKLVF D DK V YTL R EL ED AL A ADFEG EEEL R Q D L L N d APKYGNDDD R VD DI A VEVV E TFMD E V RKYK NYR g GKF 633
650
....*....|....
gi 636996776 696 SHGT L S I SN N T P L G 709
Cdd:pfam02901 634 TPSL L T I TS N V P Y G 647
PFL2-3
TIGR01774 glycyl radical enzyme, PFL2/glycerol dehydratase family; This family previously was designated ...
60-843
0e+00
glycyl radical enzyme, PFL2/glycerol dehydratase family; This family previously was designated pyruvate formate-lyase, but it now appears that members include the B12-independent glycerol dehydratase. Therefore, the functional definition of the family is being broadened. This family includes the PflF and PflD proteins of E. coli, described as isoforms of pyruvate-formate lyase found in a limited number additional species. PFL catalyzes the reaction pyruvate + CoA -> acetyl-CoA + formate, which is a step in the fermentation of glucose.
Pssm-ID: 273798 [Multi-domain]
Cd Length: 786
Bit Score: 589.95
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 60 ITP R LQA LK NQYL K AQPTI S LL RA TNL T RIS K EN EG M P KA I L R GT A FKEFCKIA P VV I Q D N EL L VG APNGGA R FGAFS P D 139
Cdd:TIGR01774 2 CMD R IEK LK KALS K PVARL S VE RA RLY T ESM K QT EG E P MI I R R AK A LAHVLENI P IQ I L D S EL I VG NMLPNP R AAIIF P E 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 140 ISWR W LRD E I D TVST RP QDPY A L SEEDK K VLREEI F PYW EGRSVDEACETQYREAGAWELSGES FV SD csyhacsg G GDS 219
Cdd:TIGR01774 82 GVGL W IIK E L D SLPN RP TNRF A V SEEDK R VLREEI A PYW QRKTIEDFAFGLMTDEMKILYTTSI FV LT -------- G EIA 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 220 NPGYDV V G ---- M R K G MLDIKA E A E AHLSK L DYGNPDDL EK IY FY K A QILTA E G V MIYAK R MSEH A A E L AA K E LNPK R KA 295
Cdd:TIGR01774 154 GISHVA V N ypyl L R R G LRWLLE E S E RRIRA L EESGVYEG EK YS FY Q A AKIVL E A V INHIL R YAKL A E E M AA S E TGES R RE 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 296 EL EM I SRVNAN V P A H KP E TFW E A M Q Y V VTI Q HL L LC E E N QTGL S I GR V DQY M YP L YK R DI EA GR MNDYQ AFE LAGCMF IK 375
Cdd:TIGR01774 234 EL LK I AEICRK V A A E KP Q TFW Q A V Q L V WLV Q SI L QQ E S N EQSI S M GR I DQY L YP F YK K DI GE GR IDREL AFE ILASLW IK 313
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 376 MS E MMWLT S EGSSKF FAG YQPFVNMCV GG VTRE G R DA T N D L T YL LMDAIRHVKVY QP T L AT RIN NK SP RKY LK KIVDVV R 455
Cdd:TIGR01774 314 TN E IVPAR S SSLEQY FAG QPTNQAVTI GG CDIY G N DA V N E L S YL MLEVTDRLRLR QP N L HV RIN AG SP ESF LK RLAEAI R 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 456 A G I G F PA CHF D DSHIKMMLAK GV SME DA R DY CLM GCVE PQKS G RL Y QWTST A YTQWPILI E TT LN H G IP L WY G KPVTPDM 535
Cdd:TIGR01774 394 S G C G N PA LFN D EAVVPAFKNA GV DDR DA L DY TTD GCVE IAPF G NS Y TSSDA A LINVAKVM E YA LN E G VD L QF G YEFGAKT 473
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 536 GSL dqy K TF E QFEAAVK E T I KYVT K WTSVMTVISQRVQR E LA P A PL M S MMY E GTM E N G RGVKS GGA M YNF g P G VVWS G L A 615
Cdd:TIGR01774 474 EKP --- K FL E DLLEKLR E Q I SHYV K LVVEGSNVLDYANA E VK P T PL L S LCV E DCF E K G VDISR GGA R YNF - T G IQAV G I A 549
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 616 N YA DS MA AIK KL VFE DKK Y TL D E L NK AL IAD F E G -- YDQI R ADCL - AA PKYGNDDD Y VD YFASDII E FTE EE HRK Y KTLY 692
Cdd:TIGR01774 550 N LG DS LV AIK GA VFE QGA Y SM D D L VE AL RKN F V G lt HEEK R HRLI n QS PKYGNDDD A VD KYTAMVL E WYC EE VNR Y RNPR 629
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 693 - SVLSH G TLSI S N N T P L G QI T G A SAS GR R A WT PL SD G I SP DH GMD TK GPTA I I K SVSK MAN EN MNI G MVH N F K IMAGL L D 771
Cdd:TIGR01774 630 g GKFAA G CYPM S A N V P F G FF T S A TPD GR K A GE PL AP G V SP ST GMD RE GPTA V I N SVSK LSY EN LPN G ALL N I K LSPAT L E 709
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636996776 772 TPQGEES LI TL LR TAS - I L GNGEM QFN YLDNAI L LD AQQ H PEKYR D L I VRVAGYSAFFVEL CKD VQD E II A RT 843
Cdd:TIGR01774 710 EEGDKQK LI EA LR KSF m E L KVMHI QFN IVKEDT L RK AQQ E PEKYR W L V VRVAGYSAFFVEL SRP VQD D II R RT 782
pflD
PRK09983 putative formate acetyltransferase 2; Provisional
60-843
4.26e-162
putative formate acetyltransferase 2; Provisional
Pssm-ID: 182181 [Multi-domain]
Cd Length: 765
Bit Score: 490.87
E-value: 4.26e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 60 I T P R LQA LK NQYLKAQPT ISL L RA TNL T RISKEN EG M P KAIL R GT A FKEFCKIAPVV I Q D N EL LV G APNGGA R F G AF SP D 139
Cdd:PRK09983 1 M T N R ISR LK TALFANTRE ISL E RA LLY T ASHRQT EG E P VILR R AK A TAYILEHVEIS I R D E EL IA G NRTVKP R A G IM SP E 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 140 ISWR WL RD E I D TVS TRPQD PY A L SEEDK KVL REE I FPYWE G RS VDEACET Q YREAGAWEL S GES F VSD csy HACS G G G DS 219
Cdd:PRK09983 81 MDPY WL LK E L D QFP TRPQD RF A I SEEDK RIY REE L FPYWE K RS MKDFING Q MTDEVKAAT S TQI F SIN --- QTDK G Q G HI 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 220 NPG Y DVV g MRK G MLDIK A EAEA H LSK ldyg N P DD leki Y FY K A QI L TA E GVMIYAK R MS E H A AEL AA KELNPK R KA EL EM 299
Cdd:PRK09983 158 IID Y PRL - LNH G LGELV A QMQQ H CQQ ---- Q P EN ---- H FY Q A AL L LL E ASQKHIL R YA E L A ETM AA NCTDAQ R RE EL LT 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 300 I SRVNANVPA HKP E TFW E A M Q YVVTIQHL L LC E E N QTG LS I GR V DQYM Y P L Y KRDIEA G rmn DYQ AF -- EL AGCMFI K MS 377
Cdd:PRK09983 229 I AEISRHNAQ HKP Q TFW Q A C Q LFWYMNII L QY E S N ASS LS L GR F DQYM L P F Y QASLTQ G --- EDP AF lk EL LESLWV K CN 305
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 378 EMMW L T S EG S SKF FAG YQPFVNMCV GG V T RE GR D A T N D L TY L LM DA IRH V KVY QP T L AT R I N NKSPRKY L K K IVDVV R A G 457
Cdd:PRK09983 306 DIVL L R S TS S ARY FAG FPTGYTALL GG L T EN GR S A V N V L SF L CL DA YQS V QLP QP N L GV R T N ALIDTPF L M K TAETI R L G 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 458 I G F P ACHF D DSHIKMM L AK GVS M EDARDY CLM GCVE PQKS GR L Y QWTST A YTQWPILI E TT L -- N H G iplwygkpvtpdm 535
Cdd:PRK09983 386 T G I P QIFN D EVVVPAF L NR GVS L EDARDY SVV GCVE LSIP GR T Y GLHDI A MFNLLKVM E IC L he N E G ------------- 452
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 536 gsl DQYK T F E QFEAAVKET I KYVTKWTSVMTV I SQRVQ R EL AP A PL M S MMYEGTM E N GR GVKS GGA M YNF G p GV VWS G L A 615
Cdd:PRK09983 453 --- NAAL T Y E GLLEQIRAK I SHYITLMVEGSN I CDIGH R DW AP V PL L S SFISDCL E K GR DITD GGA R YNF S - GV QGI G I A 528
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 616 N YA DS MA A I K KL VF EDKKYTL DEL NKA L I A D F -- EGYDQI RA DCLAA - P KYGND D D Y VD YFASDIIEFTEE E HR KY KTLY 692
Cdd:PRK09983 529 N LS DS LH A L K GM VF DQQRLSF DEL LSV L K A N F at PEGEKV RA RLINR f E KYGND I D E VD NISAELLRHYCK E VE KY QNPR 608
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 693 - SVLSH G TLSI S NNT PLG QIT GA SAS GR R A WTP L S D - G I SP DH G M D TK GPTA II KSVSK MA N ENMNI G MVH N F K IMAGL L 770
Cdd:PRK09983 609 g GYFTP G SYTV S AHV PLG SVV GA TPD GR F A GEQ L A D g G L SP ML G Q D AQ GPTA VL KSVSK LD N TLLSN G TLL N V K FTPAT L 688
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 636996776 771 DTPQ G EES L ITL LR TASI L GNGEM QFN YLDNAI L LD AQQ H P EK Y RD L I VRVAGYSAFFVEL C K DV QD E II A RT 843
Cdd:PRK09983 689 EGEA G LRK L ADF LR AFTQ L KLQHI QFN VVNADT L RE AQQ R P QD Y AG L V VRVAGYSAFFVEL S K EI QD D II R RT 761
PFL1
cd01678 Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, ...
300-843
1.52e-41
Pyruvate formate lyase 1; Pyruvate formate lyase catalyzes a key step in anaerobic glycolysis, the conversion of pyruvate and CoenzymeA to formate and acetylCoA. The PFL mechanism involves an unusual radical cleavage of pyruvate in which two cysteines and one glycine form radicals that are required for catalysis. PFL has a ten-stranded alpha/beta barrel domain that is structurally similar to those of all three ribonucleotide reductase (RNR) classes as well as benzylsuccinate synthase and B12-independent glycerol dehydratase.
Pssm-ID: 153087 [Multi-domain]
Cd Length: 738
Bit Score: 163.31
E-value: 1.52e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 300 ISR VNA N V pah KPETF W EAMQ Y VVT I Q hlllc E E N QTGL S I GRV DQYMYPLYK RD IE AG RMNDYQ A F EL AGCMFI K MSEM 379
Cdd:cd01678 231 ISR PAT N A --- QEAIQ W TYFG Y LAA I K ----- E Q N GAAM S L GRV STFLDIYIE RD LK AG TITEAE A Q EL IDQFIM K LRMV 302
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 380 MW L TSEGSSKF F A G YQPF V NMCV GG VTRE GR DATNDLTYLLMDAIRHV - KVYQ P T L ATRINN K S P --- RKYLK K I vdvvr 455
Cdd:cd01678 303 RF L RTPEYNEL F S G DPTW V TESI GG MGND GR SLVTKTSFRFLNTLYNL g PAPE P N L TVLWSE K L P enf KRFCA K V ----- 377
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 456 agigfpac HF D D S H I ----- KM M LAKGVS meda R DY CLMG CV EPQKS G RLY Q WTS t A YTQWPILIETTL N H G IPLWY G KP 530
Cdd:cd01678 378 -------- SI D T S S I qyend DL M RPDWGG ---- D DY GIAC CV SAMRI G KQM Q FFG - A RANLAKALLYAI N G G RDEKT G DQ 444
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 531 V T PD MGSL - DQ Y KTFEQ feaa V K E TIKYVTK W TS ----- VMTV I SQRVQRELAP A PL M SMM yegtmen GRG V KS ggamy N 604
Cdd:cd01678 445 V G PD IEPI t SD Y LDYDE ---- V M E NYDKSMD W LA dtyvn ALNI I HYMHDKYAYE A LQ M ALH ------- DTD V RR ----- T 508
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 605 FGP G V vw S GL ANY ADS MA AIK klv FEDK K YTL DE ln KA L IA DFE gydq I RA D cla A P K YGNDDD YV D YF A SDIIEFTEEE 684
Cdd:cd01678 509 MAF G I -- A GL SVA ADS LS AIK --- YAKV K PIR DE -- DG L AV DFE ---- I EG D --- F P R YGNDDD RA D DI A VWVVKTFMNK 574
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 685 H RK Y KT l Y -- SVLSHGT L S I SN N TPL G QI TG ASAS GRRA WT P LSD G IS P D HG M D T KG PT A IIK SV S K MANENM N I G MVHN 762
Cdd:cd01678 575 L RK H KT - Y rn AEPTQSV L T I TS N VVY G KK TG NTPD GRRA GE P FAP G AN P M HG R D K KG AL A SLA SV A K LPYRDA N D G ISNT 653
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 763 F K I MAGL L -- DTPQGEES L ITL L RTASIL G NGEMQF N Y L DNAI LLDA QQ HPEKY RD L IV RV A GY SAF FV E L CKDV Q DEI I 840
Cdd:cd01678 654 F S I VPNA L gk TDEERIDN L VGI L DGYFTK G GHHLNV N V L NRET LLDA ME HPEKY PQ L TI RV S GY AVN FV K L TREQ Q LDV I 733
...
gi 636996776 841 A RT 843
Cdd:cd01678 734 S RT 736
Gly_radical
pfam01228 Glycine radical;
725-829
9.76e-37
Glycine radical;
Pssm-ID: 426140 [Multi-domain]
Cd Length: 106
Bit Score: 133.45
E-value: 9.76e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 725 LSD GISP D HG M D TK GPTA IIK SV S K MAN E NMNI G MVH N F K IMAGL L D -- TPQ G EES L I TL LR T ASI l G NGEM QFN YL D NA 802
Cdd:pfam01228 1 VAP GISP S HG A D FE GPTA VLN SV G K IDY E VELD G ISL N Q K FLPAV L G yy DEE G YAN L N TL ID T YFE - G GHHL QFN VV D RE 79
90 100
....*....|....*....|....*..
gi 636996776 803 I L L DAQ Q HPEKY R DL I VRV A GYSA F FV 829
Cdd:pfam01228 80 T L P DAQ K HPEKY P DL T VRV S GYSA N FV 106
PRK11127
PRK11127 autonomous glycyl radical cofactor GrcA; Provisional
797-843
5.77e-11
autonomous glycyl radical cofactor GrcA; Provisional
Pssm-ID: 182983 [Multi-domain]
Cd Length: 127
Bit Score: 60.63
E-value: 5.77e-11
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 636996776 797 N Y L DNAI L L DA QQ HPEKY RD L IV RV A GY SAF F VE L CKDV Q DEI IART 843
Cdd:PRK11127 76 N V L RRET L E DA VK HPEKY PQ L TI RV S GY AVR F NS L TPEQ Q RDV IART 122
RNR_PFL
cd00576 Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...
312-452
8.28e-03
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain]
Cd Length: 401
Bit Score: 39.44
E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 636996776 312 PETFW EA M Q YVVT I QH L LLCEE N QT G L S IG R VDQYMY P LYK RD IEA G RMNDYQ A F E L A GCMFIKMS E M mwltsegss KFF 391
Cdd:cd00576 45 AKSIN EA I Q KTYQ I IA L AASNQ N GG G V S FA R ASSILS P YGS RD YAK G SGTETD A V E A A DAFNLALK E V --------- GQG 115
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 636996776 392 A G YQPFVNMCV GGV T reg RDATNDLTYLLMDAIRHVKVY ----- Q P T L AT R INNKS P r KY L K K I V D 452
Cdd:cd00576 116 N G RTGAATGFI GGV H --- KGKGDKISQEFLNLALANGGE gipln F P N L SV R VSSDK P - GI L V K A V E 177
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
