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Conserved domains on  [gi|637164839|ref|WP_024425495|]
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MULTISPECIES: BlaI/MecI/CopY family transcriptional regulator [Bacillus]

Protein Classification

BlaI/MecI/CopY family transcriptional regulator( domain architecture ID 10007832)

BlaI/MecI/CopY family transcriptional regulator similar to Mycobacterium tuberculosis transcriptional regulator BlaI and Staphylococcus aureus repressor and methicillin resistance regulatory protein MecI

CATH:  1.10.10.10
Gene Ontology:  GO:0045892|GO:0003677
PubMed:  8226686
SCOP:  4000185

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
18-138 2.69e-27

Transcriptional regulator, CopY/TcrY family [Transcription];


:

Pssm-ID: 442898  Cd Length: 125  Bit Score: 97.94  E-value: 2.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637164839  18 GPLEGRIMEILYQGEDMPIKEVQQKLSDEKPINFNTVMTVLNRLTEKGIVEKKTKGRSSIYNPILTKEEFLNEQTKWITQ 97
Cdd:COG3682    6 TEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQELRDLLD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 637164839  98 GLMDDFGPLAVNHMVDAiESADPELLKVLEARLASKKEEQQ 138
Cdd:COG3682   86 RFFGGSLKALVAAFVEE-EKLSPEELEELRKLLDEKKKKKK 125
 
Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
18-138 2.69e-27

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 97.94  E-value: 2.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637164839  18 GPLEGRIMEILYQGEDMPIKEVQQKLSDEKPINFNTVMTVLNRLTEKGIVEKKTKGRSSIYNPILTKEEFLNEQTKWITQ 97
Cdd:COG3682    6 TEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQELRDLLD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 637164839  98 GLMDDFGPLAVNHMVDAiESADPELLKVLEARLASKKEEQQ 138
Cdd:COG3682   86 RFFGGSLKALVAAFVEE-EKLSPEELEELRKLLDEKKKKKK 125
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 17-131 1.75e-22

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 85.35  E-value: 1.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637164839   17 FGPLEGRIMEILYQGEDMPIKEVQQKLSDEKPINFNTVMTVLNRLTEKGIVEKKTKGRSSIYNPILTKEEFLNEQTKWIT 96
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKDGRAFIYSPLVSREEYKAGQVKQLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 637164839   97 QGLMD-DFGPLAVNHMVDaiESADPELLKVLEARLA 131
Cdd:pfam03965  81 DRFFGgSVPALVANFVER--EKLSPDDIEELRQLLD 114
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 24-69 4.70e-03

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 34.86  E-value: 4.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 637164839  24 IMEILYQGEDMP-IKEVQQKLSDEKP-INFNTVMTVLNRLTEKGIVEK 69
Cdd:cd07153    6 ILEVLLESDGHLtAEEIYERLRKKGPsISLATVYRTLELLEEAGLVRE 53
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-89 5.96e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 33.34  E-value: 5.96e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 637164839    23 RIMEILYQGEdMPIKEVQQKLSdekpINFNTVMTVLNRLTEKGIVEKKTKGRSSIYnpILTKEEFLN 89
Cdd:smart00418   1 KILKLLAEGE-LCVCELAEILG----LSQSTVSHHLKKLREAGLVESRREGKRVYY--SLTDEKVAD 60
 
Name Accession Description Interval E-value
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
18-138 2.69e-27

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 97.94  E-value: 2.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637164839  18 GPLEGRIMEILYQGEDMPIKEVQQKLSDEKPINFNTVMTVLNRLTEKGIVEKKTKGRSSIYNPILTKEEFLNEQTKWITQ 97
Cdd:COG3682    6 TEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQELRDLLD 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 637164839  98 GLMDDFGPLAVNHMVDAiESADPELLKVLEARLASKKEEQQ 138
Cdd:COG3682   86 RFFGGSLKALVAAFVEE-EKLSPEELEELRKLLDEKKKKKK 125
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 17-131 1.75e-22

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 85.35  E-value: 1.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 637164839   17 FGPLEGRIMEILYQGEDMPIKEVQQKLSDEKPINFNTVMTVLNRLTEKGIVEKKTKGRSSIYNPILTKEEFLNEQTKWIT 96
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKDGRAFIYSPLVSREEYKAGQVKQLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 637164839   97 QGLMD-DFGPLAVNHMVDaiESADPELLKVLEARLA 131
Cdd:pfam03965  81 DRFFGgSVPALVANFVER--EKLSPDDIEELRQLLD 114
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 24-69 4.70e-03

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 34.86  E-value: 4.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 637164839  24 IMEILYQGEDMP-IKEVQQKLSDEKP-INFNTVMTVLNRLTEKGIVEK 69
Cdd:cd07153    6 ILEVLLESDGHLtAEEIYERLRKKGPsISLATVYRTLELLEEAGLVRE 53
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
23-89 5.96e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 33.34  E-value: 5.96e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 637164839    23 RIMEILYQGEdMPIKEVQQKLSdekpINFNTVMTVLNRLTEKGIVEKKTKGRSSIYnpILTKEEFLN 89
Cdd:smart00418   1 KILKLLAEGE-LCVCELAEILG----LSQSTVSHHLKKLREAGLVESRREGKRVYY--SLTDEKVAD 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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