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Conserved domains on  [gi|639237782|ref|WP_024568443|]
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MULTISPECIES: arsenate reductase family protein [Elizabethkingia]

Protein Classification

arsenate reductase family protein( domain architecture ID 10003639)

arsenate reductase family protein belongs to the thioredoxin fold superfamily, and may catalyze the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 1-110 1.55e-24

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


:

Pssm-ID: 441003  Cd Length: 115  Bit Score: 89.77  E-value: 1.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   1 MKKVFYLKTCGTCKKIMAEFNLDG--WELREIKSAPVTESELAEMY-KLTNSYEALFSKKSTQIKAREIDVKNLKEEDFK 77
Cdd:COG1393    1 MITIYGNPNCSTSRKALAWLEEAGieYEFIDYLKTPPTAEELKELLaKLGLGVEELLNTRGTTYRELGLKDKALSEEEAL 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 639237782  78 GLILDHYSFLKRPVFITDKNIFAGSDKSNLEKL 110
Cdd:COG1393   81 ALMLEHPSLIKRPIVVTGDKALVGFPPEEVLAL 113
 
Name Accession Description Interval E-value
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 1-110 1.55e-24

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 89.77  E-value: 1.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   1 MKKVFYLKTCGTCKKIMAEFNLDG--WELREIKSAPVTESELAEMY-KLTNSYEALFSKKSTQIKAREIDVKNLKEEDFK 77
Cdd:COG1393    1 MITIYGNPNCSTSRKALAWLEEAGieYEFIDYLKTPPTAEELKELLaKLGLGVEELLNTRGTTYRELGLKDKALSEEEAL 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 639237782  78 GLILDHYSFLKRPVFITDKNIFAGSDKSNLEKL 110
Cdd:COG1393   81 ALMLEHPSLIKRPIVVTGDKALVGFPPEEVLAL 113
ArsC_family cd02977
Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins ...
 3-101 3.25e-11

Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases. Spx is a general regulator that exerts negative and positive control over transcription initiation by binding to the C-terminal domain of the alpha subunit of RNA polymerase.


Pssm-ID: 239275  Cd Length: 105  Bit Score: 55.19  E-value: 3.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   3 KVFYLKTCGTCKKIMAEFNLDG--WELREIKSAPVTESELAEMYKLT-NSYEALFSKKSTQIKAR-EIDVKNLKEEDFKG 78
Cdd:cd02977    2 TIYGNPNCSTSRKALAWLEEHGieYEFIDYLKEPPTKEELKELLAKLgLGVEDLFNTRGTPYRKLgLADKDELSDEEALE 81

                         90       100
                 ....*....|....*....|...
gi 639237782  79 LILDHYSFLKRPVFITDKNIFAG 101
Cdd:cd02977   82 LMAEHPKLIKRPIVVDGDRLLVG 104
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 5-96 6.15e-10

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 52.22  E-value: 6.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782    5 FYLKTCGTCKKIMA---EFNLDgWELREIKSAPVTESELAEMYKLT-NSYEALFSKKSTQIKAREIDVKNLKEEDFKGLI 80
Cdd:pfam03960   1 YGSPNCSTCRKALAwleEHGIE-YQEIDYLETPPSKEELKDILAKLgDGVEALLNTRGTTYRELNLDKEDLSEDELLELI 79

                          90
                  ....*....|....*.
gi 639237782   81 LDHYSFLKRPVFITDK 96
Cdd:pfam03960  80 LEHPSLIRRPIVVDGG 95
spxA PRK13344
transcriptional regulator Spx; Reviewed
 1-101 7.27e-07

transcriptional regulator Spx; Reviewed


Pssm-ID: 183988  Cd Length: 132  Bit Score: 44.57  E-value: 7.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   1 MKKVFYLKTCGTCKKIMAEFNLDGWELRE--IKSAPVTESE-LAEMYKLTNSYEALFSKKSTQIKAREIDVKNLKEEDFK 77
Cdd:PRK13344   1 MIKIYTISSCTSCKKAKTWLNAHQLSYKEqnLGKEPLTKEEiLAILTKTENGIESIVSSKNRYAKALDCDIEELSVNEVI 80

                         90       100
                 ....*....|....*....|....
gi 639237782  78 GLILDHYSFLKRPVFITDKNIFAG 101
Cdd:PRK13344  81 DLIQENPRILKSPILIDDKRLQVG 104
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 3-100 1.37e-04

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 38.18  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782    3 KVFYLKTCGTCKKIMAEFNLDGWELREI--KSAPVTESELAEMYKLT-NSYEALFSKKSTqiKAREIDVKNLKE----ED 75
Cdd:TIGR01617   2 KVYGSPNCTTCKKARRWLEANGIEYQFIdiGEDGPTREELLDILSLLeDGIDPLLNTRGQ--SYRALNTSNTFLdlsdKE 79

                          90       100
                  ....*....|....*....|....*
gi 639237782   76 FKGLILDHYSFLKRPVFITDKNIFA 100
Cdd:TIGR01617  80 ALELLAEDPALLRRPLIVDTKNRLL 104
 
Name Accession Description Interval E-value
ArsC COG1393
Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and ...
 1-110 1.55e-24

Arsenate reductase or related protein, glutaredoxin family [Inorganic ion transport and metabolism];


Pssm-ID: 441003  Cd Length: 115  Bit Score: 89.77  E-value: 1.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   1 MKKVFYLKTCGTCKKIMAEFNLDG--WELREIKSAPVTESELAEMY-KLTNSYEALFSKKSTQIKAREIDVKNLKEEDFK 77
Cdd:COG1393    1 MITIYGNPNCSTSRKALAWLEEAGieYEFIDYLKTPPTAEELKELLaKLGLGVEELLNTRGTTYRELGLKDKALSEEEAL 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 639237782  78 GLILDHYSFLKRPVFITDKNIFAGSDKSNLEKL 110
Cdd:COG1393   81 ALMLEHPSLIKRPIVVTGDKALVGFPPEEVLAL 113
ArsC_family cd02977
Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins ...
 3-101 3.25e-11

Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from glutathione (GSH) via glutaredoxin (GRX), through a single catalytic cysteine. This family of predominantly bacterial enzymes is unrelated to two other families of arsenate reductases which show similarity to low-molecular-weight acid phosphatases and phosphotyrosyl phosphatases. Spx is a general regulator that exerts negative and positive control over transcription initiation by binding to the C-terminal domain of the alpha subunit of RNA polymerase.


Pssm-ID: 239275  Cd Length: 105  Bit Score: 55.19  E-value: 3.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   3 KVFYLKTCGTCKKIMAEFNLDG--WELREIKSAPVTESELAEMYKLT-NSYEALFSKKSTQIKAR-EIDVKNLKEEDFKG 78
Cdd:cd02977    2 TIYGNPNCSTSRKALAWLEEHGieYEFIDYLKEPPTKEELKELLAKLgLGVEDLFNTRGTPYRKLgLADKDELSDEEALE 81

                         90       100
                 ....*....|....*....|...
gi 639237782  79 LILDHYSFLKRPVFITDKNIFAG 101
Cdd:cd02977   82 LMAEHPKLIKRPIVVDGDRLLVG 104
ArsC pfam03960
ArsC family; This family is related to glutaredoxins pfam00462.
 5-96 6.15e-10

ArsC family; This family is related to glutaredoxins pfam00462.


Pssm-ID: 427617  Cd Length: 109  Bit Score: 52.22  E-value: 6.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782    5 FYLKTCGTCKKIMA---EFNLDgWELREIKSAPVTESELAEMYKLT-NSYEALFSKKSTQIKAREIDVKNLKEEDFKGLI 80
Cdd:pfam03960   1 YGSPNCSTCRKALAwleEHGIE-YQEIDYLETPPSKEELKDILAKLgDGVEALLNTRGTTYRELNLDKEDLSEDELLELI 79

                          90
                  ....*....|....*.
gi 639237782   81 LDHYSFLKRPVFITDK 96
Cdd:pfam03960  80 LEHPSLIRRPIVVDGG 95
spxA PRK13344
transcriptional regulator Spx; Reviewed
 1-101 7.27e-07

transcriptional regulator Spx; Reviewed


Pssm-ID: 183988  Cd Length: 132  Bit Score: 44.57  E-value: 7.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   1 MKKVFYLKTCGTCKKIMAEFNLDGWELRE--IKSAPVTESE-LAEMYKLTNSYEALFSKKSTQIKAREIDVKNLKEEDFK 77
Cdd:PRK13344   1 MIKIYTISSCTSCKKAKTWLNAHQLSYKEqnLGKEPLTKEEiLAILTKTENGIESIVSSKNRYAKALDCDIEELSVNEVI 80

                         90       100
                 ....*....|....*....|....
gi 639237782  78 GLILDHYSFLKRPVFITDKNIFAG 101
Cdd:PRK13344  81 DLIQENPRILKSPILIDDKRLQVG 104
spxA PRK01655
transcriptional regulator Spx; Reviewed
 1-101 3.66e-06

transcriptional regulator Spx; Reviewed


Pssm-ID: 179316  Cd Length: 131  Bit Score: 42.75  E-value: 3.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   1 MKKVFYLKTCGTCKKIMA---EFNLDgWELREIKSAPVTESELAEMYKLT-NSYEALFSKKSTQIKAREIDVKNLKEEDF 76
Cdd:PRK01655   1 MVTLFTSPSCTSCRKAKAwleEHDIP-FTERNIFSSPLTIDEIKQILRMTeDGTDEIISTRSKVFQKLNVDVESLSLQDL 79

                         90       100
                 ....*....|....*....|....*
gi 639237782  77 KGLILDHYSFLKRPVFITDKNIFAG 101
Cdd:PRK01655  80 IKLISDNPGLLRRPIIIDEKRLQVG 104
PRK12559 PRK12559
transcriptional regulator Spx; Provisional
 1-110 6.22e-05

transcriptional regulator Spx; Provisional


Pssm-ID: 79035  Cd Length: 131  Bit Score: 39.70  E-value: 6.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   1 MKKVFYLKTCGTCKKIMA--EFNLDGWELREIKSAPVTESELAEMYKLTNS-YEALFSKKSTQIKAREIDVKNLKEEDFK 77
Cdd:PRK12559   1 MVVLYTTASCASCRKAKAwlEENQIDYTEKNIVSNSMTVDELKSILRLTEEgATEIISTRSKTFQDLNINIEELSLNEFY 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 639237782  78 GLILDHYSFLKRPVFITDKNIFAGSDKSNLEKL 110
Cdd:PRK12559  81 KLIIEHPLMLRRPIMLDEKRLQIGFNDEEIRKF 113
arsC_related TIGR01617
transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins ...
 3-100 1.37e-04

transcriptional regulator, Spx/MgsR family; This model represents a portion of the proteins within the larger set covered by pfam03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. [Regulatory functions, DNA interactions]


Pssm-ID: 273720  Cd Length: 117  Bit Score: 38.18  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782    3 KVFYLKTCGTCKKIMAEFNLDGWELREI--KSAPVTESELAEMYKLT-NSYEALFSKKSTqiKAREIDVKNLKE----ED 75
Cdd:TIGR01617   2 KVYGSPNCTTCKKARRWLEANGIEYQFIdiGEDGPTREELLDILSLLeDGIDPLLNTRGQ--SYRALNTSNTFLdlsdKE 79

                          90       100
                  ....*....|....*....|....*
gi 639237782   76 FKGLILDHYSFLKRPVFITDKNIFA 100
Cdd:TIGR01617  80 ALELLAEDPALLRRPLIVDTKNRLL 104
ArsC_Yffb cd03035
Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein ...
 3-101 1.15e-03

Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine suggest that it is likely to function as a glutathione (GSH)-dependent thiol reductase. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from GSH via glutaredoxin, through a single catalytic cysteine.


Pssm-ID: 239333  Cd Length: 105  Bit Score: 35.65  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639237782   3 KVFYLKTCGTCKKIM---AEFNLDgWELREIKSAPVTESELAEMYKLTnSYEALFSKKSTQIKA-REIDVKNLKEEDFKG 78
Cdd:cd03035    2 TLYGIKNCDTVKKARkwlEARGVA-YTFHDYRKDGLDAATLERWLAKV-GWETLLNKRGTTWRKlDDAQKAALDAAKAIA 79

                         90       100
                 ....*....|....*....|...
gi 639237782  79 LILDHYSFLKRPVFITDKNIFAG 101
Cdd:cd03035   80 LMLEHPSLIKRPVLETGGKVLVG 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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