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Conserved domains on  [gi|639305470|ref|WP_024591726|]
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MULTISPECIES: TonB-dependent receptor domain-containing protein [unclassified Pseudoalteromonas]

Protein Classification

porin family protein( domain architecture ID 229388)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OM_channels super family cl21487
Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in ...
 56-947 1.04e-42

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20), which associate as trimers. Maltoporin-like channels have specificities for various sugars and form 18 beta-stranded barrels (18,22), which associate as trimers. Ligand-gated protein channels cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force and they form monomeric, (22,24) barrels. The 150-200 N-terminal residues form a plug that blocks the channel from the periplasmic end.


The actual alignment was detected with superfamily member cd01347:

Pssm-ID: 473880 [Multi-domain]  Cd Length: 635  Bit Score: 166.09  E-value: 1.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  56 PVTVISGEQLMNTGAVNIGEALNNLPALGNTYSMANSGRFIgtaglnilDLRNMGTDRTLVLVNGKRhVSSSAGSQSVDT 135
Cdd:cd01347    1 SVSVITAEDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTI--------SIRGFGPDRTLVLVDGLP-LASSNYGRGVDL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 136 NTIPSVWVERVEIITGGASAVYGADAVTGVVNFILKDNIEGMDFSVTrgfadlSSYNNEKATFSYGSNFDndrgnaafai 215
Cdd:cd01347   72 NTIPPELIERVEVLKGPSSALYGSGAIGGVVNIITKRPTDEFGGSVT------AGYGSDNSGSSGGGGFD---------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 216 eysgqdslnaldhpwtstsfsslrrevlpgedtnsldfpdkiltpNAGYYAINNAGVYALEDSTKFINSFNPDSSARDLY 295
Cdd:cd01347  136 ---------------------------------------------VSGALADDGAFGARLYGAYRDGDGTIDGDGQADDS 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 296 ignnvdlyscaecdffnlgqfeeiqpEFERYNVNFKVNYDVTDDLNVYFDAKYVNSQGESIGQPAFFFFDDENSIKIDNP 375
Cdd:cd01347  171 --------------------------DEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSS 224

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 376 YldpaikarmeeqgvdsimvnrmmTDLGRRIENNTRETTRFVTGLKGTVF-EDWELDTSVVYGQTDLERENGANMIVANY 454
Cdd:cd01347  225 N-----------------------TNGDRDWDYRDRYRKRASLGLEHDLNdTGWTLRANLSYSYTDNDGDPLILNGGNNA 281

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 455 FNAldavedtngnvvcrsaaaqadgcvpvnimgfgspsqqaiDYINTVSVGTSTIKQTVISGSLaNGAIFELPAGYVgVA 534
Cdd:cd01347  282 AGG---------------------------------------DLGRSGYSSERDTTQLGFDAGL-NAPFGTGPVAHT-LT 320

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 535 FGAEYRKEESETKepdnaegtffnalgedkgsfnVREVFFEATMPILTDLPLIqdlvfdTAVRHADYSTIGEAT------ 608
Cdd:cd01347  321 LGVEYRREELDEK---------------------QTALYAQDTIELTDDLTLT------LGLRYDHYDQDSKDTiaggtt 373

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 609 --------SWKLGLDWTVNDELRVRVTQSAALRAPNISEVFGAASQTFynvddpcradnlgdlsngatrtancaalgvas 680
Cdd:cd01347  374 akksyshwSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGG-------------------------------- 421

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 681 dfnsgydaasldGLSSGNRDVKGEESTSTTVGIVYQPEflENALLTIDYWEIELEDAIDTInaqdildrcvdsatginnq 760
Cdd:cd01347  422 ------------TAAVGNPNLKPEKSKQYELGLKYDPG--DGLTLSAALFRIDIKNEIVST------------------- 468

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 761 ycnlitrNTNSEITLIQNSVlNVAGQKASGVDFELGYDFDaleGSFKTRLIGTYLIERKDYPFQDDPSNYIeyagtTGEA 840
Cdd:cd01347  469 -------PTNTGLGLVTVYV-NGGKARIRGVELEASYDLT---DGLGLTGSYTYTDTEVKRTDGATTGNRL-----PGIP 532

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 841 KWQTNLSVSY--VMDNFFSTVETRFLSEVELYTNfeldsnpNPSNQMSYGKYFITDMTVGYNFNSGLGVKVGVDNVFNRK 918
Cdd:cd01347  533 KHTANLGLDYelPDEGLTAGGGVRYRGKQYADTA-------NGNNTVKVPGYTLVDLSASYQFTKNLTLRLGVNNLFDKD 605

                        890       900
                 ....*....|....*....|....*....
gi 639305470 919 LPYGSRGTSAGSASYDNIGRFGYINLSYS 947
Cdd:cd01347  606 YYTSLSVRGSGLYGYYGPGRTYYLSVSYK 634
 
Name Accession Description Interval E-value
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 56-947 1.04e-42

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 166.09  E-value: 1.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  56 PVTVISGEQLMNTGAVNIGEALNNLPALGNTYSMANSGRFIgtaglnilDLRNMGTDRTLVLVNGKRhVSSSAGSQSVDT 135
Cdd:cd01347    1 SVSVITAEDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTI--------SIRGFGPDRTLVLVDGLP-LASSNYGRGVDL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 136 NTIPSVWVERVEIITGGASAVYGADAVTGVVNFILKDNIEGMDFSVTrgfadlSSYNNEKATFSYGSNFDndrgnaafai 215
Cdd:cd01347   72 NTIPPELIERVEVLKGPSSALYGSGAIGGVVNIITKRPTDEFGGSVT------AGYGSDNSGSSGGGGFD---------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 216 eysgqdslnaldhpwtstsfsslrrevlpgedtnsldfpdkiltpNAGYYAINNAGVYALEDSTKFINSFNPDSSARDLY 295
Cdd:cd01347  136 ---------------------------------------------VSGALADDGAFGARLYGAYRDGDGTIDGDGQADDS 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 296 ignnvdlyscaecdffnlgqfeeiqpEFERYNVNFKVNYDVTDDLNVYFDAKYVNSQGESIGQPAFFFFDDENSIKIDNP 375
Cdd:cd01347  171 --------------------------DEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSS 224

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 376 YldpaikarmeeqgvdsimvnrmmTDLGRRIENNTRETTRFVTGLKGTVF-EDWELDTSVVYGQTDLERENGANMIVANY 454
Cdd:cd01347  225 N-----------------------TNGDRDWDYRDRYRKRASLGLEHDLNdTGWTLRANLSYSYTDNDGDPLILNGGNNA 281

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 455 FNAldavedtngnvvcrsaaaqadgcvpvnimgfgspsqqaiDYINTVSVGTSTIKQTVISGSLaNGAIFELPAGYVgVA 534
Cdd:cd01347  282 AGG---------------------------------------DLGRSGYSSERDTTQLGFDAGL-NAPFGTGPVAHT-LT 320

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 535 FGAEYRKEESETKepdnaegtffnalgedkgsfnVREVFFEATMPILTDLPLIqdlvfdTAVRHADYSTIGEAT------ 608
Cdd:cd01347  321 LGVEYRREELDEK---------------------QTALYAQDTIELTDDLTLT------LGLRYDHYDQDSKDTiaggtt 373

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 609 --------SWKLGLDWTVNDELRVRVTQSAALRAPNISEVFGAASQTFynvddpcradnlgdlsngatrtancaalgvas 680
Cdd:cd01347  374 akksyshwSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGG-------------------------------- 421

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 681 dfnsgydaasldGLSSGNRDVKGEESTSTTVGIVYQPEflENALLTIDYWEIELEDAIDTInaqdildrcvdsatginnq 760
Cdd:cd01347  422 ------------TAAVGNPNLKPEKSKQYELGLKYDPG--DGLTLSAALFRIDIKNEIVST------------------- 468

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 761 ycnlitrNTNSEITLIQNSVlNVAGQKASGVDFELGYDFDaleGSFKTRLIGTYLIERKDYPFQDDPSNYIeyagtTGEA 840
Cdd:cd01347  469 -------PTNTGLGLVTVYV-NGGKARIRGVELEASYDLT---DGLGLTGSYTYTDTEVKRTDGATTGNRL-----PGIP 532

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 841 KWQTNLSVSY--VMDNFFSTVETRFLSEVELYTNfeldsnpNPSNQMSYGKYFITDMTVGYNFNSGLGVKVGVDNVFNRK 918
Cdd:cd01347  533 KHTANLGLDYelPDEGLTAGGGVRYRGKQYADTA-------NGNNTVKVPGYTLVDLSASYQFTKNLTLRLGVNNLFDKD 605

                        890       900
                 ....*....|....*....|....*....
gi 639305470 919 LPYGSRGTSAGSASYDNIGRFGYINLSYS 947
Cdd:cd01347  606 YYTSLSVRGSGLYGYYGPGRTYYLSVSYK 634
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 13-905 3.98e-42

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 163.87  E-value: 3.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  13 CALITAAATASNSVLAQDEQATKIERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPALgntysmaNS 92
Cdd:COG4771    4 ASLLLLLALAAQAADALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALRLLPGV-------SV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  93 GRFIGTAGLNILDLRNMGTDRTLVLVNGKRhVSSSAGSQSVDTNTIPSVWVERVEIITGGASAVYGADAVTGVVNFILKD 172
Cdd:COG4771   77 TRSGGRGGSSGISIRGLGGDRVLVLIDGVP-VNNPALGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIITKK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 173 NIEGMDFSVTrgfADLSSYNNEKATFSYGSNFDNDRGNAAFAIEYSGQDSLNaldhpwtstsfsslrrevlpgeDTNSLD 252
Cdd:COG4771  156 PTDELEGSVS---LGYGSNGNGTYSGSLSLGGPGDKLSFLLSGSYRDRDGYL----------------------DYRNGG 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 253 FPDkiltpnagyyainnagvyaledstkfinsfnpdssardlyignnvdlyscaecdffnlgqfeeiQPEFERYNVNFKV 332
Cdd:COG4771  211 FVG----------------------------------------------------------------NSGYERYNLNAKL 226

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 333 NYDVTDDLNVYFDAKYVNSQGESIGQPAFFFFDDENsikidnpyldpaikarmeeqgvdsimvnrmmtdlGRRIENNTRE 412
Cdd:COG4771  227 GYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEISSD----------------------------------NAGDRDTTTD 272

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 413 TTRFVTGLKGTVfeDWELDTSVVYGQTDLERENGANMIVANYFNALDaVEDTNGNVvcrsaaaqadgcvpvnimgfgsps 492
Cdd:COG4771  273 RGNYSLRYNGDL--GDNLDLSLYYSRTDRDSTNGSLGGSTGSFSDSD-DTTYGLEL------------------------ 325

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 493 qqaiDYINTVSVGTStikqtvisgslangaifelpagyvgVAFGAEYRKEESETKepdnaegtffNALGEDKGSFNVREV 572
Cdd:COG4771  326 ----DLTYPLGGNHT-------------------------LTLGAEYRYDDLDSS----------SFLGGADASRDTYGL 366

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 573 FFEATMPILtdlpliQDLVFDTAVRHADYSTIGE----ATSWKLGLDWTVNDELRVRVTQSAALRAPNISEVFGAASQTF 648
Cdd:COG4771  367 FAQDEWKLT------DKLTLTAGLRYDYYSTFGAsnytAFSPRLGLRYDLSDNLTLRASYGRGFRAPSLAELYGSGTGTP 440

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 649 YNVddpcradnlgdlsngatrtancaalgvasdfnsgydaasldglSSGNRDVKGEESTSTTVGIVYQPeFLENALLTID 728
Cdd:COG4771  441 GRY-------------------------------------------VLGNPDLKPETSDNYELGLEYRL-GNGGLSLSLT 476

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 729 YWEIELEDAIDTINaqdildrcVDSATGINNQYcnlitrntnseitliqnsvLNVAGQKASGVDFELGYDFDAlegSFKT 808
Cdd:COG4771  477 GFYTDIKDLIVLVP--------VGPGPGDVLQY-------------------ENVGKARTYGLELELKYRLGK---GLTL 526

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 809 RLIGTYLIERKDYPFQDDPSNYIeyagttgeAKWQTNLSVSYVMDNFFSTVETRFlsevelYTNFELDSNPNPSNQMSYG 888
Cdd:COG4771  527 TASYTYLDSKIDDGDTGEPLPNV--------PPHKANLGLDYRLPKWWLLLLLTR------YYGGRYVTPPSGRLEGYTP 592

                        890
                 ....*....|....*..
gi 639305470 889 KYFITDMTVGYNFNSGL 905
Cdd:COG4771  593 GYTLLDLRASYKLTKNL 609
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 53-165 5.92e-20

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 85.78  E-value: 5.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   53 APAPVTVISGEQLMNTGAVNIGEALNNLPALGNTYSMANSGRFIgtaglnilDLRNMGTDRTLVLVNGKRHVSSSAGSqs 132
Cdd:pfam07715   5 TPGSVSVVTAEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSI--------SIRGFGSNRVLVLVDGVPLNSGGGGS-- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 639305470  133 VDTNTIPSVWVERVEIITGGASAVYGADAVTGV 165
Cdd:pfam07715  75 VDLNSIDPEDIERVEVLKGPASALYGSGAIGGV 107
PRK13483 PRK13483
ligand-gated channel protein;
1-169 4.63e-19

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 92.53  E-value: 4.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   1 MKRHNLLSTSikcALITAAATASNSVLAQDEQATKIERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNL 80
Cdd:PRK13483   1 MKKYLAQVIS---ALCLLPAVFVTHALAQAAPDKTMETVVVTASGYEQQIRDAPASISVITREDLENRFYRDLTDALLDV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  81 PALgntysmansgrfIGTAGLNILD--LRNMGTDRTLVLVNGKRHVSSSAGSQSvDTNTIPSVW------VERVEIITGG 152
Cdd:PRK13483  78 PGV------------VVTGGGDRTDisLRGMGSQYTLILVDGKRQSSRETRPNS-DGPGVEQAWtpplaaIERIEVIRGP 144

                        170
                 ....*....|....*..
gi 639305470 153 ASAVYGADAVTGVVNFI 169
Cdd:PRK13483 145 MSSLYGSDAIGGVINII 161
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 37-214 1.36e-14

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 78.20  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   37 ERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPAlgntYSMANSGRFIGTAgLNIldlRNMGTDRTLV 116
Cdd:TIGR01785   2 DTVTVTATRTRQVLSEAPASVSVISGEQIESKQANNLADALNTVPG----VDVTGGGRPPGQS-INI---RGLQDNRVLV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  117 LVNGKRHVSSSAGSQ----SVDTNTIpsvwvERVEIITGGASAVYGADAVTGVVNFILKDNI----EGMDFSVtrgfadl 188
Cdd:TIGR01785  74 VVDGARQNYQRGGAHngslFVDPELL-----KRIEIVKGPSSSLYGSGALGGVVAFRTKDAAdllrPGQLFGG------- 141

                         170       180
                  ....*....|....*....|....*.
gi 639305470  189 ssynneKATFSYGSNFDNDRGNAAFA 214
Cdd:TIGR01785 142 ------LAKLSYGSNNNSFGGSVAVA 161
 
Name Accession Description Interval E-value
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 56-947 1.04e-42

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 166.09  E-value: 1.04e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  56 PVTVISGEQLMNTGAVNIGEALNNLPALGNTYSMANSGRFIgtaglnilDLRNMGTDRTLVLVNGKRhVSSSAGSQSVDT 135
Cdd:cd01347    1 SVSVITAEDIEKQPATSLADLLRRIPGVSVTRGGGGGGSTI--------SIRGFGPDRTLVLVDGLP-LASSNYGRGVDL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 136 NTIPSVWVERVEIITGGASAVYGADAVTGVVNFILKDNIEGMDFSVTrgfadlSSYNNEKATFSYGSNFDndrgnaafai 215
Cdd:cd01347   72 NTIPPELIERVEVLKGPSSALYGSGAIGGVVNIITKRPTDEFGGSVT------AGYGSDNSGSSGGGGFD---------- 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 216 eysgqdslnaldhpwtstsfsslrrevlpgedtnsldfpdkiltpNAGYYAINNAGVYALEDSTKFINSFNPDSSARDLY 295
Cdd:cd01347  136 ---------------------------------------------VSGALADDGAFGARLYGAYRDGDGTIDGDGQADDS 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 296 ignnvdlyscaecdffnlgqfeeiqpEFERYNVNFKVNYDVTDDLNVYFDAKYVNSQGESIGQPAFFFFDDENSIKIDNP 375
Cdd:cd01347  171 --------------------------DEERYNVAGKLDWRPDDDTRLTLDAGYQDQDADGPGGTLPANGTGSSLGGGPSS 224

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 376 YldpaikarmeeqgvdsimvnrmmTDLGRRIENNTRETTRFVTGLKGTVF-EDWELDTSVVYGQTDLERENGANMIVANY 454
Cdd:cd01347  225 N-----------------------TNGDRDWDYRDRYRKRASLGLEHDLNdTGWTLRANLSYSYTDNDGDPLILNGGNNA 281

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 455 FNAldavedtngnvvcrsaaaqadgcvpvnimgfgspsqqaiDYINTVSVGTSTIKQTVISGSLaNGAIFELPAGYVgVA 534
Cdd:cd01347  282 AGG---------------------------------------DLGRSGYSSERDTTQLGFDAGL-NAPFGTGPVAHT-LT 320

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 535 FGAEYRKEESETKepdnaegtffnalgedkgsfnVREVFFEATMPILTDLPLIqdlvfdTAVRHADYSTIGEAT------ 608
Cdd:cd01347  321 LGVEYRREELDEK---------------------QTALYAQDTIELTDDLTLT------LGLRYDHYDQDSKDTiaggtt 373

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 609 --------SWKLGLDWTVNDELRVRVTQSAALRAPNISEVFGAASQTFynvddpcradnlgdlsngatrtancaalgvas 680
Cdd:cd01347  374 akksyshwSPSLGLVYKLTDGLSLYASYSQGFRAPSLGELYGGGSHGG-------------------------------- 421

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 681 dfnsgydaasldGLSSGNRDVKGEESTSTTVGIVYQPEflENALLTIDYWEIELEDAIDTInaqdildrcvdsatginnq 760
Cdd:cd01347  422 ------------TAAVGNPNLKPEKSKQYELGLKYDPG--DGLTLSAALFRIDIKNEIVST------------------- 468

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 761 ycnlitrNTNSEITLIQNSVlNVAGQKASGVDFELGYDFDaleGSFKTRLIGTYLIERKDYPFQDDPSNYIeyagtTGEA 840
Cdd:cd01347  469 -------PTNTGLGLVTVYV-NGGKARIRGVELEASYDLT---DGLGLTGSYTYTDTEVKRTDGATTGNRL-----PGIP 532

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 841 KWQTNLSVSY--VMDNFFSTVETRFLSEVELYTNfeldsnpNPSNQMSYGKYFITDMTVGYNFNSGLGVKVGVDNVFNRK 918
Cdd:cd01347  533 KHTANLGLDYelPDEGLTAGGGVRYRGKQYADTA-------NGNNTVKVPGYTLVDLSASYQFTKNLTLRLGVNNLFDKD 605

                        890       900
                 ....*....|....*....|....*....
gi 639305470 919 LPYGSRGTSAGSASYDNIGRFGYINLSYS 947
Cdd:cd01347  606 YYTSLSVRGSGLYGYYGPGRTYYLSVSYK 634
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 13-905 3.98e-42

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 163.87  E-value: 3.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  13 CALITAAATASNSVLAQDEQATKIERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPALgntysmaNS 92
Cdd:COG4771    4 ASLLLLLALAAQAADALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALRLLPGV-------SV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  93 GRFIGTAGLNILDLRNMGTDRTLVLVNGKRhVSSSAGSQSVDTNTIPSVWVERVEIITGGASAVYGADAVTGVVNFILKD 172
Cdd:COG4771   77 TRSGGRGGSSGISIRGLGGDRVLVLIDGVP-VNNPALGGGGDLSYIPPDDIERIEVIRGPASALYGSDAIGGVINIITKK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 173 NIEGMDFSVTrgfADLSSYNNEKATFSYGSNFDNDRGNAAFAIEYSGQDSLNaldhpwtstsfsslrrevlpgeDTNSLD 252
Cdd:COG4771  156 PTDELEGSVS---LGYGSNGNGTYSGSLSLGGPGDKLSFLLSGSYRDRDGYL----------------------DYRNGG 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 253 FPDkiltpnagyyainnagvyaledstkfinsfnpdssardlyignnvdlyscaecdffnlgqfeeiQPEFERYNVNFKV 332
Cdd:COG4771  211 FVG----------------------------------------------------------------NSGYERYNLNAKL 226

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 333 NYDVTDDLNVYFDAKYVNSQGESIGQPAFFFFDDENsikidnpyldpaikarmeeqgvdsimvnrmmtdlGRRIENNTRE 412
Cdd:COG4771  227 GYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEISSD----------------------------------NAGDRDTTTD 272

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 413 TTRFVTGLKGTVfeDWELDTSVVYGQTDLERENGANMIVANYFNALDaVEDTNGNVvcrsaaaqadgcvpvnimgfgsps 492
Cdd:COG4771  273 RGNYSLRYNGDL--GDNLDLSLYYSRTDRDSTNGSLGGSTGSFSDSD-DTTYGLEL------------------------ 325

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 493 qqaiDYINTVSVGTStikqtvisgslangaifelpagyvgVAFGAEYRKEESETKepdnaegtffNALGEDKGSFNVREV 572
Cdd:COG4771  326 ----DLTYPLGGNHT-------------------------LTLGAEYRYDDLDSS----------SFLGGADASRDTYGL 366

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 573 FFEATMPILtdlpliQDLVFDTAVRHADYSTIGE----ATSWKLGLDWTVNDELRVRVTQSAALRAPNISEVFGAASQTF 648
Cdd:COG4771  367 FAQDEWKLT------DKLTLTAGLRYDYYSTFGAsnytAFSPRLGLRYDLSDNLTLRASYGRGFRAPSLAELYGSGTGTP 440

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 649 YNVddpcradnlgdlsngatrtancaalgvasdfnsgydaasldglSSGNRDVKGEESTSTTVGIVYQPeFLENALLTID 728
Cdd:COG4771  441 GRY-------------------------------------------VLGNPDLKPETSDNYELGLEYRL-GNGGLSLSLT 476

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 729 YWEIELEDAIDTINaqdildrcVDSATGINNQYcnlitrntnseitliqnsvLNVAGQKASGVDFELGYDFDAlegSFKT 808
Cdd:COG4771  477 GFYTDIKDLIVLVP--------VGPGPGDVLQY-------------------ENVGKARTYGLELELKYRLGK---GLTL 526

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 809 RLIGTYLIERKDYPFQDDPSNYIeyagttgeAKWQTNLSVSYVMDNFFSTVETRFlsevelYTNFELDSNPNPSNQMSYG 888
Cdd:COG4771  527 TASYTYLDSKIDDGDTGEPLPNV--------PPHKANLGLDYRLPKWWLLLLLTR------YYGGRYVTPPSGRLEGYTP 592

                        890
                 ....*....|....*..
gi 639305470 889 KYFITDMTVGYNFNSGL 905
Cdd:COG4771  593 GYTLLDLRASYKLTKNL 609
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
39-234 4.94e-29

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 117.67  E-value: 4.94e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  39 VEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPALgntySMANSGRFIGTAGLNIldlRNMGTDRTLVLV 118
Cdd:COG4206    1 VVVTATRLEQSKSDLTGSVTVIDAEELERSGATSLADALRRVPGV----QVSSSGGPGSAASISI---RGLGSNQTLVLI 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 119 NGKRhvSSSAGSQSVDTNTIPSVWVERVEIITGGASAVYGADAVTGVVNFILKDNIEGMDFSVTrgfADLSSYNNEKATF 198
Cdd:COG4206   74 DGVP--LNDPSLGGVDLSLIPPDDIERIEVLKGAASALYGSDAIGGVINITTKKGKKGFKGSVS---ASYGSFGTRRLSA 148

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 639305470 199 SYGSNfdNDRGNAAFAIEYSGQDSLNALDHPWTSTS 234
Cdd:COG4206  149 SLSGG--AGKFSYSLSASYRRSDGYRYNDPDLRNND 182
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
36-933 2.59e-25

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 112.23  E-value: 2.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  36 IERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPalgntySMANSGRFIGTAGLNIldlRNMGT--DR 113
Cdd:COG1629    1 LEEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLLRRVP------GVSVTSAGGGAGQISI---RGFGGggNR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 114 TLVLVNGKRhvSSSAGSQSVDTNTIPSVWVERVEIITGGASAVYGADAVTGVVNFILKDNIEGMDFSVTrgfADLSSYNN 193
Cdd:COG1629   72 VLVLVDGVP--LNDPSGGDGGLSYIDPEDIERVEVLRGPSSALYGSGALGGVINIVTKKPKDGKGGEVS---ASYGSYGT 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 194 EKATFSYGSNfdNDRGNAAFAIEYSGQDSlnaldhpwtstsfsslrrevlpgedtnsldfpdkiltpnagyyainnagvy 273
Cdd:COG1629  147 YRASLSLSGG--NGKLAYRLSASYRDSDG--------------------------------------------------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 274 aledstkfinsfnpdssardlYIGNNvdlyscaecdffnlgqfeeiqpEFERYNVNFKVNYDVTDDLNVYFDAKYVNSQG 353
Cdd:COG1629  174 ---------------------YRDNS----------------------DSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQ 210

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 354 ESIGQPAFFFFD-DENSIKIDNPYLDPaikarmeeqgvdsimvnrmmtdlgrrieNNTRETTRFVTGLKGTVFED-WELD 431
Cdd:COG1629  211 DSPGYLTLAALRpRGAMDDGTNPYSND----------------------------TDDNTRDRYSLSLEYEHLGDgLKLS 262

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 432 TSVVYGQTDLerenganmivaNYFNALDAVEDTNGNvvcrsaaaqadgcvpvnimgfgspsqqaidyintvsVGTSTIKQ 511
Cdd:COG1629  263 ASAYYRYDDT-----------DLDSDFTPTPADGGT------------------------------------LEQTDFDN 295

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 512 TVISGSLANGAIFELPAGYVGVaFGAEYRKEESETKEPDNAEG----TFFNALGEDKGSFNVREVFFEATMPILTDLPLI 587
Cdd:COG1629  296 RTYGLELRLTYDLGFGGKHTLL-VGLDYQRQDLDGSGYPLDLGsgslPTLTSGADDDGTTTSLALYAQDTYKLTDKLTLT 374

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 588 QDLVFDTAVRHADYSTIGE----------ATSWKLGLDWTVNDELRVRVTQSAALRAPNISEVFGAASQTFynvddpcra 657
Cdd:COG1629  375 AGLRYDYVSYDVDDTVTGTdsasgsrsysAFSPSLGLTYQLSPNLSLYASYSRGFRAPTFGELYANGTDPY--------- 445

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 658 dnlgdlsngatrtancaalgvasdfnsgydaasldglSSGNRDVKGEESTSTTVGIVYQPeFLENALLTIDYWEIELEDA 737
Cdd:COG1629  446 -------------------------------------SVGNPDLKPETSTNYELGLRYRL-LDGRLSLSLALFYSDVDNE 487

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 738 IDTINaqdildrcVDSATGINNQYcnlitrntnseitliqnsvLNVAGQKASGVDFELGYDFDAlegSFKTRLIGTYLie 817
Cdd:COG1629  488 ILSVP--------LPNDSGFSTYY-------------------TNAGKARSYGVELELSYQLTP---GLSLNASYSYT-- 535

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 818 rkDYPFQDDPSNYIEYAGT--TGEAKWQTNLSVSY-VMDNFFSTVETRFLSEVELytnfeldsnPNPSNQMSYGKYFITD 894
Cdd:COG1629  536 --DAKFDDDTDGSADLDGNrlPGVPPLTANLGLTYeFPGGWSLGLGVRYVGDRYL---------DDANTQGAPGGYTLVD 604

                        890       900       910
                 ....*....|....*....|....*....|....*....
gi 639305470 895 MTVGYNFNSGLGVKVGVDNVFNRKLPYGSRGTSAGSASY 933
Cdd:COG1629  605 LGAGYRFGDNLTLSLGVDNLFDKKYATSLSVRASNVRGF 643
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 53-165 5.92e-20

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 85.78  E-value: 5.92e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   53 APAPVTVISGEQLMNTGAVNIGEALNNLPALGNTYSMANSGRFIgtaglnilDLRNMGTDRTLVLVNGKRHVSSSAGSqs 132
Cdd:pfam07715   5 TPGSVSVVTAEDIEDQGATNLADALRGVPGVSVSSGGGGGGSSI--------SIRGFGSNRVLVLVDGVPLNSGGGGS-- 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 639305470  133 VDTNTIPSVWVERVEIITGGASAVYGADAVTGV 165
Cdd:pfam07715  75 VDLNSIDPEDIERVEVLKGPASALYGSGAIGGV 107
PRK13483 PRK13483
ligand-gated channel protein;
1-169 4.63e-19

ligand-gated channel protein;


Pssm-ID: 184080 [Multi-domain]  Cd Length: 660  Bit Score: 92.53  E-value: 4.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   1 MKRHNLLSTSikcALITAAATASNSVLAQDEQATKIERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNL 80
Cdd:PRK13483   1 MKKYLAQVIS---ALCLLPAVFVTHALAQAAPDKTMETVVVTASGYEQQIRDAPASISVITREDLENRFYRDLTDALLDV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  81 PALgntysmansgrfIGTAGLNILD--LRNMGTDRTLVLVNGKRHVSSSAGSQSvDTNTIPSVW------VERVEIITGG 152
Cdd:PRK13483  78 PGV------------VVTGGGDRTDisLRGMGSQYTLILVDGKRQSSRETRPNS-DGPGVEQAWtpplaaIERIEVIRGP 144

                        170
                 ....*....|....*..
gi 639305470 153 ASAVYGADAVTGVVNFI 169
Cdd:PRK13483 145 MSSLYGSDAIGGVINII 161
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 487-947 9.38e-19

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 90.60  E-value: 9.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  487 GFGSPSQQAIDYINTVSVGTSTIKQTVISGSLANGAIFelpaGYVGVAFGAEYRKEESETKEPDNAEGTFFNAlgEDKGS 566
Cdd:pfam00593  98 SSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLL----GVELRTAGLDYRRLDDDAYDPYDPANPSSSS--YSDTT 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  567 FNVREVFFEATMPILTDLPLI--------QDLVFDTAVRHADYSTIGEATSWKLGLDWTVNDELRVRVTQSAALRAPNIS 638
Cdd:pfam00593 172 TDSYGLYLQDNIKLTDRLTLTlglrydhySTDGDDGNGGGDNFSRSYSAFSPRLGLVYKPTDNLSLYASYSRGFRAPSLG 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  639 EVFGAASQTFYNVddpcradnlgdlsngatrtancaalgvasdfnsgydaasldgLSSGNRDVKGEESTSTTVGIVYQPE 718
Cdd:pfam00593 252 ELYGSGSGGGGGA------------------------------------------VAGGNPDLKPETSDNYELGLKYDDG 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  719 FLenaLLTIDYWEIELEDAIDTINAQDILDRCVDSATginnqycnlitrntnseitliqnsvlNVAGQKASGVDFELGYD 798
Cdd:pfam00593 290 RL---SLSLALFYIDIKNLITSDPDGPGLGGTVYTYT--------------------------NVGKARIRGVELELSGR 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  799 FdalegsFKTRLIGTYLIERKDYPFQDDPSNYIEYAGTtgeAKWQTNLSVSY--VMDNFFSTVETRFLSEVELYTNfeld 876
Cdd:pfam00593 341 L------WGLGLSGGGYTYTDADDDADADDTGNPLPNV---PRHTANLGLTYdfPLGGWGARLGARYVGSGERRYG---- 407

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639305470  877 snpNPSNQMSYGKYFITDMTVGYNFNSGLGVKVGVDNVFNRKLPYGSRGTSAGSASYDNIGRFGYINLSYS 947
Cdd:pfam00593 408 ---DAANTFKTPGYTLVDLSAGYRLNKNLTLRLGVNNLFDKYYKRYYSSGGGNLGGYPGPGRTFYLGLSYK 475
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 1-171 2.58e-16

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 83.78  E-value: 2.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   1 MKRHNLLstsIKCALITAAATASNSVLAQDEQAtkiERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNL 80
Cdd:PRK10064   1 MFRLNPF---VRVGLCASAISCAWPVLAVDDDG---ETMVVTASAVEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  81 PALGNTYSMANSgrfigtaglNILDLRNMGTDRTLVLVNGKRHVSSSA--GSQSVDTNTIPSVWVERVEIITGGASAVYG 158
Cdd:PRK10064  75 PGVQLTNEGDNR---------KGVSIRGLDSSYTLILIDGKRVNSRNAvfRHNDFDLNWIPVDAIERIEVVRGPMSSLYG 145

                        170
                 ....*....|...
gi 639305470 159 ADAVTGVVNFILK 171
Cdd:PRK10064 146 SDALGGVVNIITK 158
TonB-hemin TIGR01785
TonB-dependent heme/hemoglobin receptor family protein; This model represents the ...
 37-214 1.36e-14

TonB-dependent heme/hemoglobin receptor family protein; This model represents the TonB-dependent outer membrane heme/hemoglobin receptor/transporter found in bacteria which live in contact with animals (which contain hemoglobin or other heme-bearing globins) or legumes (which contain leghemoglobin). Some species having hits to this model such as Nostoc, Caulobacter and Chlorobium do not have an obvious source of hemoglobin-like proteins in their biological niche and so the possibility exists that they act on some other substance. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273807 [Multi-domain]  Cd Length: 665  Bit Score: 78.20  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   37 ERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPAlgntYSMANSGRFIGTAgLNIldlRNMGTDRTLV 116
Cdd:TIGR01785   2 DTVTVTATRTRQVLSEAPASVSVISGEQIESKQANNLADALNTVPG----VDVTGGGRPPGQS-INI---RGLQDNRVLV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  117 LVNGKRHVSSSAGSQ----SVDTNTIpsvwvERVEIITGGASAVYGADAVTGVVNFILKDNI----EGMDFSVtrgfadl 188
Cdd:TIGR01785  74 VVDGARQNYQRGGAHngslFVDPELL-----KRIEIVKGPSSSLYGSGALGGVVAFRTKDAAdllrPGQLFGG------- 141

                         170       180
                  ....*....|....*....|....*.
gi 639305470  189 ssynneKATFSYGSNFDNDRGNAAFA 214
Cdd:TIGR01785 142 ------LAKLSYGSNNNSFGGSVAVA 161
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
19-222 3.61e-14

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 76.89  E-value: 3.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  19 AATASNSVLAQDEQATKIERVEVTGSRILREGAIA-PAPVTVISGEQLMNTGAVNIGEALNNLPALgNTYSMANSGRF-- 95
Cdd:COG4772    6 AAALLLAAAAAAEAATTLETVVVTGSRAAEARLKDvPGSVSVVDREELENQAATSLREVLRRVPGV-NVQEEDGFGLRpn 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  96 IGTAGLNILDLRnmgtdRTLVLVNGkrhVSSSA----GSQSVDTNTIPSVwvERVEIITGGASAVYGADAVTGVVNFILK 171
Cdd:COG4772   85 IGIRGLGPRRSR-----GITLLEDG---IPIAPapygDPAAYYFPDLERM--ERIEVLRGAAALRYGPQTVGGAINFVTR 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 639305470 172 DNIEGMDFSVTrgfADLSSYNNEKATFSYGsnfdNDRGNAAFAIEYSGQDS 222
Cdd:COG4772  155 TIPTAFGGELR---VTGGSFGYRRTHASVG----GTVGNFGYLVEYSRKRG 198
PRK13513 PRK13513
ligand-gated channel protein;
12-171 8.48e-14

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 75.57  E-value: 8.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  12 KCALITAAATASNSVLA-QDEQATKIERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPALGNTysma 90
Cdd:PRK13513  10 KAALVIAAAISSQAYAAeKTNTATPTDTMVVTASGFQQRIQDAPASISVVTREQLENKAYRDVTDALKDVPGVVVT---- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  91 nsgrfiGTAGLNILDLRNMGTDRTLVLVNGKRhVSSSAGSQSVDTNTIPSVW------VERVEIITGGASAVYGADAVTG 164
Cdd:PRK13513  86 ------GGGSTSDISIRGMAAKYTLILVDGKR-VDTRSTRPNSDGSGIEQGWlpplaaIERIEVVRGPMSSLYGSDAMGG 158


                 ....*..
gi 639305470 165 VVNFILK 171
Cdd:PRK13513 159 VINIITR 165
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
1-171 1.01e-13

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 75.43  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   1 MKRHNLLSTSIKcalITAAATASNSVLAQDEqatKIERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNL 80
Cdd:PRK13484   1 MKNKYIIAPGIA---VMCSAVISSGYASSDK---KEDTLVVTASGFTQQLRNAPASVSVITSEQLQKKPVSDLVDAVKDV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  81 PALGNTysmansgrfiGTAGLNILDLRNMGTDRTLVLVNGKRHVSSSA---GSQSVDTNTIPSV-WVERVEIITGGASAV 156
Cdd:PRK13484  75 EGISIT----------GGNEKPDISIRGLSGDYTLILVDGRRQSGRESrpnGSGGFEAGFIPPVeAIERIEVIRGPMSSL 144

                        170
                 ....*....|....*
gi 639305470 157 YGADAVTGVVNFILK 171
Cdd:PRK13484 145 YGSDAIGGVINIITK 159
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
1-171 2.04e-13

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 74.30  E-value: 2.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   1 MKRHNLLSTSIKCALITAAATASNSV-LAQDEQATKIERVEVTGSRILREgaiAPApVTVISGEQLMNTGAVN-IGEALN 78
Cdd:PRK13524   2 NKKIHSLALLVNLGIYGVAQAAEAEDaKTDDTPASHEDTIVVTAAEQNLQ---APG-VSTITAEDIRKRPPANdVSEIIR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  79 NLPAL---GNTYSmansgrfiGTAGLN-ILDLRNMGTDRTLVLVNGKRhVSSS-------AGSQSV--DTNTIPSVWVER 145
Cdd:PRK13524  78 TMPGVnltGNSTS--------GQRGNNrQIDIRGMGPENTLILIDGKP-VSSRnsvrygwRGERDTrgDTNWVPPEMIER 148

                        170       180
                 ....*....|....*....|....*.
gi 639305470 146 VEIITGGASAVYGADAVTGVVNFILK 171
Cdd:PRK13524 149 IEVLRGPAAARYGNGAAGGVVNIITK 174
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 1-171 2.15e-13

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 74.41  E-value: 2.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   1 MKRHNLLSTSIkcALITAAATASNSVLAQDEQATKIERVEVTGSRILREgaiAPApVTVISGEQLMNTGAVN-IGEALNN 79
Cdd:PRK13528   3 MRVNKILWLLT--VLLVGLNSPVSAAESSDDDNGETMVVEATAEQELKQ---QPG-VSIITAEDIKKRPPVNdLSDIIRK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  80 LPAL---GNTYSmansgrfiGTAGLN-ILDLRNMGTDRTLVLVNGKRHVSSSA------GSQSV--DTNTIPSVWVERVE 147
Cdd:PRK13528  77 MPGVnltGNSAS--------GTRGNNrQIDIRGMGPENTLILIDGVPVTSRNSvryswrGERDTrgDTNWVPPEMVERIE 148

                        170       180
                 ....*....|....*....|....
gi 639305470 148 IITGGASAVYGADAVTGVVNFILK 171
Cdd:PRK13528 149 VIRGPAAARYGSGAAGGVVNIITK 172
PRK13486 PRK13486
TonB-dependent receptor;
1-184 1.10e-12

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 71.98  E-value: 1.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   1 MKRHNLLSTSIKCAlitaAATASNSVLAQDEQAtkierveVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNL 80
Cdd:PRK13486   1 MRITTLASVVIPCL----GFSASSIAAAEDVMI-------VSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRSV 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  81 PALGNTYSMANSGrfigtaGLNIlDLRNMGTDRTLVLVNGKRHVSSS----AGSQSVDTNTIPSV-WVERVEIITGGASA 155
Cdd:PRK13486  70 EGVDVESGTGKTG------GLEI-SIRGMPASYTLILIDGVRQGGSSdvtpNGFSAMNTGFMPPLaAIERIEVIRGPMST 142

                        170       180
                 ....*....|....*....|....*....
gi 639305470 156 VYGADAVTGVVNFILKDNIEGMDFSVTRG 184
Cdd:PRK13486 143 LYGSDAMGGVVNIITRKNADKWLSSVNAG 171
btuB PRK10641
TonB-dependent vitamin B12 receptor BtuB;
12-192 1.31e-10

TonB-dependent vitamin B12 receptor BtuB;


Pssm-ID: 236730 [Multi-domain]  Cd Length: 614  Bit Score: 65.01  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  12 KCALITAAATASNSVLAQDEQAtkiERVEVTGSRILREGAIAPAPVTVISGEQLMNTGAVNIGEALNNLPALgntySMAN 91
Cdd:PRK10641   4 KASLLTALSVTAFSGWAQDTSP---DTLVVTANRFQQPVSTVLAPTTVVTRDDIDRWQSKSVNDVLRRLPGV----DIAQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  92 SGrfiGTAGLNILDLRNMGTDRTLVLVNGKRhvSSSAG-SQSVDTNTIPSVWVERVEIITGGASAVYGADAVTGVVNFIL 170
Cdd:PRK10641  77 NG---GLGQLSSLFIRGTNSSHVLVLIDGVR--LNQAGiSGSADLSQIPISLVQRIEYIRGPRSAVYGSDAIGGVVNIIT 151

                        170       180
                 ....*....|....*....|..
gi 639305470 171 KDNIEGMDFSVTRGFADLSSYN 192
Cdd:PRK10641 152 TRDKPGTTLSAGWGSNGYQNYD 173
TonB-Xanth-Caul TIGR01782
TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane ...
 36-948 1.85e-09

TonB-dependent receptor; This model represents a family of TonB-dependent outer-membrane receptors which are found mainly in Xanthomonas and Caulobacter. These appear to represent the expansion of a paralogous family in that the 22 X. axonopodis (21 in X. campestris) and 18 C. crescentus sequences are more closely related to each other than any of the many TonB-dependent receptors found in other species. In fact, the Crescentus and Xanthomonas sequences are inseparable on a phylogenetic tree using a PAM-weighted neighbor-joining method, indicating that one of the two genuses may have acquired this set of receptors from the other. The mechanism by which this family is shared between Xanthomonas, a gamma proteobacterial plant pathogen and Caulobacter, an alpha proteobacterial aquatic organism is unclear. [Transport and binding proteins, Porins]


Pssm-ID: 273804 [Multi-domain]  Cd Length: 845  Bit Score: 61.58  E-value: 1.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   36 IERVEVTGSRILREGAI-----APAPVTVISGEQLMNTGAVNIGEALNNLPALgNTYSMANSGRFIgtaglnilDLRNMG 110
Cdd:TIGR01782   1 LDAVQVTGQRASLEKAIdakrdADSVVDVISAEDIGKLPDVNVAEALQRVPGV-SIERDQGEGRYV--------SVRGLG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  111 TDRTLVLVNGKRHVSSSAGSQSVDTNTIPSVWVERVEII-TGGASAVygADAVTGVVN------FILKDNieGMDFSVTR 183
Cdd:TIGR01782  72 PSYNRTTLNGRTIASTDSGGRAFSLDLLPSELVSGVEVYkTPTADMD--EGGIGGTVDlrtrspFDYDGR--TLSGSAQG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  184 GFADLSSYNNEKATFSYGSNFDNDRGNAAFAIEYSGQDSLNALDHPWTStsfsslrrevlpgedtnsldfpdkiltpNAG 263
Cdd:TIGR01782 148 GYNDLAGKDKPGPRGAASYSWTFGDGQFGVLLSASYQKRDFAEDNVETE----------------------------NWG 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  264 YYAINnagvyaledstkfinsfnpDSSARDLYIGNNVDLYScaecdffnlgqfeeIQPEFERYNVNFKVNYDVTDDLNVY 343
Cdd:TIGR01782 200 TYTSA-------------------DGGAQGLYFPRGVRYRS--------------YRNDRERKGVNGSLQWRPSDALELY 246

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  344 FDAKYvnsqgesigqpaFFFFDDENSIKID---NPYLDPAIKARMEEQG--VDSIMVNRMMTDLGRRIENNTRETTRFVT 418
Cdd:TIGR01782 247 LDTLY------------SKYDDDETRQQIEfrtLNGGSTVITSNQTATSgaLVQGTVANLQILVEARYNEEKETTTSLTL 314

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  419 GLKGTvFEDWELDTSVVYGQTDLERENGANMIVANYFnALDAVeDTNGNVVcRSAAAQADGCVPVNimgFGSPSQQAIDY 498
Cdd:TIGR01782 315 GGEWT-GDRWTLDGDLGYSKATRDRPDRVTRFFTAPT-PGYDF-DYRGGPT-LTLGTPADGDDASN---YTNPANGELRR 387

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  499 INtvsvgtstIKQTVISGSLANGAI-FELPAGYVGVAFGAEYRKEESETKEPDN----------------------AEGT 555
Cdd:TIGR01782 388 TQ--------ISYQKAEDSEDAAQLdATFDGPFTSLKFGVRYRRRDKTNRGSRYrrsiigatgasglagvpsdlagAGLD 459

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  556 FFNALGEDKGSFNVREVFFEATMPILTDlpliqDLVFDTAVRHADYSTIGEATS-------WKLGLDWTVNDELRVRVTQ 628
Cdd:TIGR01782 460 GGLGGPLTGWDPADLDAFLNAARGDAAG-----GGTYTYASTAPNTYTVTEDTTaayamanFDTGLRLRGNVGVRYERTD 534

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  629 --SAALRAPNISEVFGAASQTF-----YNVDDPC-----RADNLGDLSNGATRTANCAALG-VASDFNSGYDAASLD-GL 694
Cdd:TIGR01782 535 qtSDGWQSQPAANGTGSVLVPVsadrdYTDVLPSlnlayDLTDDLVLRFAASKTITRPDFGdLAANTSLSDDGTGGTvTV 614

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  695 SSGNRDVKGEESTSttVGIVYQPEFLENALLTIDYWEIELEDAIdtinaQDILDRCVDSATGINNQYCNLITRNTNSEit 774
Cdd:TIGR01782 615 SGGNPDLKPYESDN--LDLSLEWYFGPGGLLSAAVFYKDIKNFI-----VTTTSTETNDGGGGLVVAGVLVSRPVNGG-- 685

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  775 liqnsvlnvAGQKASGVdfELGYD--FDALEGSFK---TRLIGTYLIERKDYPFQDDPSNYIeyaGTTGEAKWQTNLSVS 849
Cdd:TIGR01782 686 ---------KAGKIRGV--ELGYQqtFDFLPGPLSgfgVQANYTYVDSEADPSVDGVQRRKL---PLPGLSKNTANATLY 751

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  850 YVMDNFFSTVETRFLSEVELYTNfELDSNPNPSNQMSYGKYfitDMTVGYNFNSGLGVKVGVDNVFNRKLPYGSRGTSAG 929
Cdd:TIGR01782 752 YEKGGFSARLSYNYRSDYLLDVG-GSNINRLDRYVDPRGQL---DLSASYQVSDHLSLGLQASNLTNEPSRWYTGGKQRP 827

                         970
                  ....*....|....*....
gi 639305470  930 SASYDNiGRFGYINLSYSL 948
Cdd:TIGR01782 828 REYVET-GRTYMLGLRYKF 845
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 54-249 3.84e-09

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 60.50  E-value: 3.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   54 PAPVTVISGEQLMNTGAVNIGEALNNLPALGNTYSMANSGRfigtaglNILDLRNMG--TDRTLVLVNGKRhVSSSAGSQ 131
Cdd:TIGR01783   3 PQSVSVITRQELEDQQAGSLSEALQRVPGVVVGGSGGTTQF-------GNITIRGFGleVDIDNVYLDGVP-LLSRGNLA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  132 SVDTNTipsvwVERVEIITGGASAVYGADAVTGVVNFILKDNIEGMDFSVTRGFadlSSYNNEKATFSYGSNFDNDrGNA 211
Cdd:TIGR01783  75 IVDPAM-----VERVEVLRGPASLLYGGSAPGGVINIVTKRPQDEPKGSVTFGA---GTRSGYRTAFDLGGPLGAD-GTF 145

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 639305470  212 AFAIEYSGQDSLNALDHPWTSTSFSSLRREVLPGEDTN 249
Cdd:TIGR01783 146 RGRLNGARQDGDSFYDGAGEETRLGATATDWQLDDRTL 183
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
54-348 5.65e-09

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 59.89  E-value: 5.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  54 PAPVTVISGEQLMNTGAVNIGEALNNLPAL-GNTYSMANSGRFIgtaglnildLRNMGTdRTLVLVNGKRhvssSAGSQS 132
Cdd:COG4774   10 PQSVTVVTRELIEDQGATSLADALRNVPGVtFGAGEGGNGDSFS---------IRGFSA-SGDIYVDGLR----DPGQYR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 133 VDTNTIpsvwvERVEIITGGASAVYGADAVTGVVNFILKdniEGMDFSVTRGFADLSSYNNEKATFSYGSNFDNDrgnAA 212
Cdd:COG4774   76 RDTFNL-----ERVEVLKGPASVLYGRGSPGGVINLVTK---RPTDEPFTEVTLTYGSDGQRRATLDVNGPLGDD---LA 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470 213 FAIEYSGQDSlnaldHPWtsTSFSSLRREVL-------PGEDTNsldfpdkiLTPNAGYY---AINNAGVYALEDStkfi 282
Cdd:COG4774  145 YRLNGMYRDS-----DSY--RDGVDNDRWGIapsltwrLGDRTR--------LTLDYEYQdddRTPDYGVPAVANG---- 205

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 639305470 283 nsfNPDSSARDLYIGNNVDLYscaecdffnlgqfeeiqpEFERYNVNFKVNYDVTDDLNVYFDAKY 348
Cdd:COG4774  206 ---RPVDVDRSTFYGQPDDYS------------------DSETDSATLRLEHDFNDNWTLRNALRY 250
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 17-171 1.92e-08

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 58.37  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  17 TAAATASNSVLAQDEQATKIERVEVTGSRILREGAIA----------------PAPVTVISGEQLMNTGAVNIGEALNNL 80
Cdd:COG4773   13 AAAGALAQAAAAAAAEATTLPEVTVTGTAEGTGGYTAkssstatkldtplretPQSVSVVTRQLIEDQGATTLDDALRNV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  81 PAL-GNTYSMANSGRFIgtaglnildLRnmGTDRTLVLVNGKRhvSSSAGSQSVDTNTIpsvwvERVEIITGGASAVYGA 159
Cdd:COG4773   93 PGVtVSSYDGGGRDSFS---------IR--GFSIDNYLRDGLP--LGGFGGGQPDTANL-----ERVEVLKGPAGLLYGA 154

                        170
                 ....*....|..
gi 639305470 160 DAVTGVVNFILK 171
Cdd:COG4773  155 GSPGGLVNLVTK 166
PRK09840 PRK09840
catecholate siderophore receptor Fiu; Provisional
 2-222 1.17e-06

catecholate siderophore receptor Fiu; Provisional


Pssm-ID: 182105 [Multi-domain]  Cd Length: 761  Bit Score: 52.50  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   2 KRHNLLSTSIKCALITAAATASNSVLAQdEQATKIERVEVTGSRILREGAIA-----------PAPVTVISGEQLMNTGA 70
Cdd:PRK09840  10 RQFHSLAFFAGLCIGITPVAQALAAEGQ-TNADDTLVVEASTPSLYAPDQSAdpkfsqpladtTQTITVISEQVIKDQGA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  71 VNIGEALNNLPALGNTYSMANSGRFIGTAglniLDLRNMGTDRTlVLVNGKRHVsssaGSQSVDTNTIpsvwvERVEIIT 150
Cdd:PRK09840  89 TNLTEALRNVPGVGTFFAGENGNTTTGDA----IYMRGFDTSNS-IYVDGIRDI----GSISRDTFNT-----EQVEVIK 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 639305470 151 GGASAVYGADAVTGVVNFILKDniEGMDFSVTrGFADLSSYNNEKATFSYGSNFDndrGNAAFAIEYSGQDS 222
Cdd:PRK09840 155 GPSGTDYGRSAPTGSINMISKQ--PRNDSGID-ASASIGSAWFRRGTLDVNQVIG---DTTAVRLNVMGEKT 220
PRK14050 PRK14050
TonB-dependent siderophore receptor;
14-171 5.43e-04

TonB-dependent siderophore receptor;


Pssm-ID: 237595 [Multi-domain]  Cd Length: 728  Bit Score: 44.02  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  14 ALITAAATASNSVLAQDEQATKIERVEVTGSRILREGAIAPA-----------------------PVTVISGEQLMNTGA 70
Cdd:PRK14050  17 GVALAALVLSGLVAAQEGNTTQLETIVVEGGNAASATATGPVdgyvakatatgsktdtpiteipqSVSVVGRQEMDDRGV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  71 VN-IGEALNNLPALgntysmanSGRFIGTAG-LNILDLRNMGTDRTLVLVNGKRHVSSSAGSQSVDtntipSVWVERVEI 148
Cdd:PRK14050  97 TNkVDEALRYTPGV--------LSQPFGTDGdTDWFYIRGFDATQTGVFLDGLNLFSYGFGGFQID-----PFMLERVEV 163

                        170       180
                 ....*....|....*....|...
gi 639305470 149 ITGGASAVYGADAVTGVVNFILK 171
Cdd:PRK14050 164 LKGPASVLYGGSNPGGIVNMVSK 186
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 26-357 6.43e-03

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 40.27  E-value: 6.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470   26 VLAQDEQAtkIERVEVTGSRILREGAIAPApVTVISGEQLMNTGAVNIGEALN-NLPALgNTYSmaNSGRFIGTAGLNIL 104
Cdd:TIGR04056  70 TLKEDTQE--LDEVVVVGYGTQKKKSLTGA-VSTVKAKELKKVPVSNLSNALQgKVAGV-IITQ--SSGEPGGDAEIWIR 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  105 DLRNMGTDRT-LVLVNGkrhVSSSAGSQSVDTNTIpsvwvERVEIITGGAS-AVYGADAVTGVvnfILkdniegmdfsVT 182
Cdd:TIGR04056 144 GISSFGGNNSpLYVIDG---VPRDNGLSDLNPEDI-----ESISVLKDASAtAIYGSRGANGV---IL----------IT 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  183 --RGfadlssyNNEKATFSYgsnfdndRGNAAFAIEYSGQDSLNALDhpwtstsFSSLRREVLpgedTNSLDFPDKILTP 260
Cdd:TIGR04056 203 tkRG-------KEGKPKISY-------NAEFGFSTPTRLPEMLNAYE-------YAELYNEAL----LNRGSSPPDIYTD 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639305470  261 NAGYYAINNAGVYALED-----------STKFINSFNPDSsardlyiGNNVDLYscaecdFFNLGQFEE----IQPEFER 325
Cdd:TIGR04056 258 EEIEAYRNGLDPDLYPNtdwqdeifkrtAFNQRHNLSVSG-------GTEKARY------YVSLGYYNEegilKNSDYKR 324

                         330       340       350
                  ....*....|....*....|....*....|..
gi 639305470  326 YNVNFKVNYDVTDDLNVYFDAKYVNSQGESIG 357
Cdd:TIGR04056 325 YNFRANIDAKLTKTLKLSLNVSGSLSKYNNPG 356
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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