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Conserved domains on  [gi|639316652|ref|WP_024594631|]
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MULTISPECIES: sensor histidine kinase [Pseudoalteromonas]

Protein Classification

sensor histidine kinase( domain architecture ID 11468388)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals, such as Bacillus subtilis thermosensor DesK which regulates the order of membrane lipids by controlling the expression of the gene encoding delta 5-acyl-lipid desaturase, oxygen sensor histidine kinase NreB which is involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen, sensor histidine kinase LiaS which is involved in sensing cell wall stress, and Staphylococcus aureus VraS which positively modulates cell wall biosynthesis

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10500846|10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
135-364 1.64e-49

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


:

Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 166.72  E-value: 1.64e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 135 FLGVALILCATLFSYGIA-----AKRESLYKKREQESANQLEQlAAIAERERIARDLHDILGHSLSSIALKAELANKLNQ 209
Cdd:COG4585    6 LLGALALLVGALLGLLLAlvllrARRAERAAELERELAARAEE-AREEERRRIARELHDGVGQSLSAIKLQLEAARRLLD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 210 gERYAQANSEIAQVADLARQLLSDVRSAVSDLK-----QLNLVSQVAQLKQRLIEQ-GFNVSFNVV--LNALPAKVEGIA 281
Cdd:COG4585   85 -ADPEAAREELEEIRELAREALAELRRLVRGLRppaldDLGLAAALEELAERLLRAaGIRVELDVDgdPDRLPPEVELAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 282 GLIIKEAVTNLLRHSNTKNCEINIEQTAQQLLITVIDHG----PCSTLNSGNGLNGIKERAEQLNGSAAFTCGDN--FTL 355
Cdd:COG4585  164 YRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGvgfdPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGggTRV 243


                 ....*....
gi 639316652 356 KVVLPITAK 364
Cdd:COG4585  244 RATLPLAAA 252
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
135-364 1.64e-49

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 166.72  E-value: 1.64e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 135 FLGVALILCATLFSYGIA-----AKRESLYKKREQESANQLEQlAAIAERERIARDLHDILGHSLSSIALKAELANKLNQ 209
Cdd:COG4585    6 LLGALALLVGALLGLLLAlvllrARRAERAAELERELAARAEE-AREEERRRIARELHDGVGQSLSAIKLQLEAARRLLD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 210 gERYAQANSEIAQVADLARQLLSDVRSAVSDLK-----QLNLVSQVAQLKQRLIEQ-GFNVSFNVV--LNALPAKVEGIA 281
Cdd:COG4585   85 -ADPEAAREELEEIRELAREALAELRRLVRGLRppaldDLGLAAALEELAERLLRAaGIRVELDVDgdPDRLPPEVELAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 282 GLIIKEAVTNLLRHSNTKNCEINIEQTAQQLLITVIDHG----PCSTLNSGNGLNGIKERAEQLNGSAAFTCGDN--FTL 355
Cdd:COG4585  164 YRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGvgfdPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGggTRV 243


                 ....*....
gi 639316652 356 KVVLPITAK 364
Cdd:COG4585  244 RATLPLAAA 252
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 178-242 1.37e-17

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 76.12  E-value: 1.37e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639316652  178 ERERIARDLHDILGHSLSSIALKAELANKLNQGERyAQANSEIAQVADLARQLLSDVRSAVSDLK 242
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDP-EEAREQLDAIRELAREALQELRRLLGDLR 64
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 281-360 2.80e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 64.88  E-value: 2.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 281 AGLIIKEAVTNLLRHSNTKNCEINIEQTAQQLLITVIDHGPCSTLN-----SGNGLNGIKERAEQLNGSAAFTCGDN--F 353
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPappggGGFGLLGMRERAELLGGTLTIGSRPGggT 80


                 ....*..
gi 639316652 354 TLKVVLP 360
Cdd:cd16917   81 RVTARLP 87
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
179-360 4.77e-10

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 60.76  E-value: 4.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 179 RERIARDLHDILGHSLSSIALKAELANKLNQGERYAQANSE-IAQ----VADLARQLLSDVRSAVsdLKQLNLVSQVAQL 253
Cdd:PRK11644 302 RRDVARELHDEIGQTITAIRTQAGIIKRLAADNASVKQSAQlIEQlslgVYDTVRRLLGRLRPRQ--LDDLTLEQAIRSL 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 254 KQRLI--EQGFNVSFNVVLN--ALPAKVEGIAGLIIKEAVTNLLRHSNTKNCEINIEQTAQQLLITVIDHG---PCSTLN 326
Cdd:PRK11644 380 MREMEleDRGIVSHLDWRIDesALSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGsglPPGSGQ 459

                        170       180       190
                 ....*....|....*....|....*....|....
gi 639316652 327 SGNGLNGIKERAEQLNGSAAFTCGDNFTLKVVLP 360
Cdd:PRK11644 460 QGFGLRGMRERVTALGGTLTISCTHGTRLSVSLP 493
 
Name Accession Description Interval E-value
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
135-364 1.64e-49

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 166.72  E-value: 1.64e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 135 FLGVALILCATLFSYGIA-----AKRESLYKKREQESANQLEQlAAIAERERIARDLHDILGHSLSSIALKAELANKLNQ 209
Cdd:COG4585    6 LLGALALLVGALLGLLLAlvllrARRAERAAELERELAARAEE-AREEERRRIARELHDGVGQSLSAIKLQLEAARRLLD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 210 gERYAQANSEIAQVADLARQLLSDVRSAVSDLK-----QLNLVSQVAQLKQRLIEQ-GFNVSFNVV--LNALPAKVEGIA 281
Cdd:COG4585   85 -ADPEAAREELEEIRELAREALAELRRLVRGLRppaldDLGLAAALEELAERLLRAaGIRVELDVDgdPDRLPPEVELAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 282 GLIIKEAVTNLLRHSNTKNCEINIEQTAQQLLITVIDHG----PCSTLNSGNGLNGIKERAEQLNGSAAFTCGDN--FTL 355
Cdd:COG4585  164 YRIVQEALTNALKHAGATRVTVTLEVDDGELTLTVRDDGvgfdPEAAPGGGLGLRGMRERAEALGGTLTIGSAPGggTRV 243


                 ....*....
gi 639316652 356 KVVLPITAK 364
Cdd:COG4585  244 RATLPLAAA 252
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 178-242 1.37e-17

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 76.12  E-value: 1.37e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639316652  178 ERERIARDLHDILGHSLSSIALKAELANKLNQGERyAQANSEIAQVADLARQLLSDVRSAVSDLK 242
Cdd:pfam07730   1 ERNRIARELHDSVGQSLTAIKLQLELARRLLDRDP-EEAREQLDAIRELAREALQELRRLLGDLR 64
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 162-363 5.12e-15

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 76.20  E-value: 5.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 162 REQESANQLEQLAA-----------IAERER--IARDLHDILGHSLSSIALKAELANKLNQGERYAQANSEIAQVA---- 224
Cdd:COG3851  263 RQRQLNQQLEQELRenralarqlvsAEESERreIARELHDEIGQNITAIRTQASILKRLAPQPEIEQSAQSIESLAlriy 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 225 DLARQLLSDVRSAVsdLKQLNLVSQVAQLKQRLI--EQGFNVSFN--VVLNALPAKVEGIAGLIIKEAVTNLLRHSNTKN 300
Cdd:COG3851  343 DTTRRLLDRLRPAV--LDELGLEEALRELPRELAfeEPGISCQLDlrGDPSLLDDTLQLTLYRLVQEALTNILKHAEASQ 420

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639316652 301 CEINIEQTAQQLLITVIDHG---PCSTLNSGNGLNGIKERAEQLNGSAAFTCGDNFT-LKVVLPITA 363
Cdd:COG3851  421 IRISLSQDKRLLSLEIRDDGiglPPELRAKGFGLRGMRERVRALGGDFRLSSAPKGTrLSVLLPTPA 487
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 281-360 2.80e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 64.88  E-value: 2.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 281 AGLIIKEAVTNLLRHSNTKNCEINIEQTAQQLLITVIDHGPCSTLN-----SGNGLNGIKERAEQLNGSAAFTCGDN--F 353
Cdd:cd16917    1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGFDGPappggGGFGLLGMRERAELLGGTLTIGSRPGggT 80


                 ....*..
gi 639316652 354 TLKVVLP 360
Cdd:cd16917   81 RVTARLP 87
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
179-360 4.77e-10

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 60.76  E-value: 4.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 179 RERIARDLHDILGHSLSSIALKAELANKLNQGERYAQANSE-IAQ----VADLARQLLSDVRSAVsdLKQLNLVSQVAQL 253
Cdd:PRK11644 302 RRDVARELHDEIGQTITAIRTQAGIIKRLAADNASVKQSAQlIEQlslgVYDTVRRLLGRLRPRQ--LDDLTLEQAIRSL 379

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 254 KQRLI--EQGFNVSFNVVLN--ALPAKVEGIAGLIIKEAVTNLLRHSNTKNCEINIEQTAQQLLITVIDHG---PCSTLN 326
Cdd:PRK11644 380 MREMEleDRGIVSHLDWRIDesALSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGsglPPGSGQ 459

                        170       180       190
                 ....*....|....*....|....*....|....
gi 639316652 327 SGNGLNGIKERAEQLNGSAAFTCGDNFTLKVVLP 360
Cdd:PRK11644 460 QGFGLRGMRERVTALGGTLTISCTHGTRLSVSLP 493
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
157-348 3.01e-08

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 55.24  E-value: 3.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 157 SLYKKREQEsanQLEQLAAIAERERIARDLHDILGHSLSsiALKAELAN-KLNQGERYAQANSEIAQ----VADLARQ-- 229
Cdd:PRK10935 345 GLYFNQAQK---QQQQLLLMEERATIARELHDSLAQVLS--YLKIQLTLlKRSLDEDNAKAQSIIAEfdqaLSDAYRQlr 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 230 -LLSDVRSAV--SDLKQlNLVSQVAQLKQ----------RLIEQGFNVSFNVvlNALPakvegiaglIIKEAVTNLLRHS 296
Cdd:PRK10935 420 eLLTTFRLTIqeANLGS-ALEEMLDQLRNqtdakitldcRLPSQALDAQQQV--HLLQ---------IIREATLNAIKHA 487

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 639316652 297 NTKNCEINIEQTAQ-QLLITVIDHG----PCSTLNSGNGLNGIKERAEQLNGSAAFT 348
Cdd:PRK10935 488 NASEIAVSCVTNPDgEHTVSIRDDGigigELKEPEGHYGLNIMQERAERLGGTLTIS 544
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
164-342 7.48e-07

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 50.82  E-value: 7.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 164 QESANQleQLAAIAERERIARDLHDILGHSLSsiALKAELANKLNQGERYAQANseiaqvadlaRQLLSDVR----SAVS 239
Cdd:PRK10600 349 QQERQQ--QLIVMEERATIARELHDSIAQSLS--CMKMQVSCLQMQGDALPESS----------RELLSQIRnelnASWR 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 240 DLK--------QLN-------LVSQVAQLKQRLieqGFNVSFNVVL--NALPAKvEGIAGL-IIKEAVTNLLRHSNTKNC 301
Cdd:PRK10600 415 QLRellttfrlQLTepglrpaLEASCEEFSARF---GFPVKLDYQLppRLVPSH-QAIHLLqIAREALSNALKHAQASEV 490

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 639316652 302 EINIEQTAQQLLITVIDHGpCstlnsgnglnGIKERAEQLN 342
Cdd:PRK10600 491 VVTVAQNQNQVKLSVQDNG-C----------GVPENAERSN 520
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
171-321 1.77e-05

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 45.67  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 171 EQLAAIAERERIARDLHDILGH----SLSSIALKAELANKLN------QGERYAQANSEIAQVADLARQLLS----DVRS 236
Cdd:COG2205    4 EALEELEELERLKSEFLANVSHelrtPLTSILGAAELLLDEEdlspeeRRELLEIIRESAERLLRLIEDLLDlsrlESGK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 237 AVSDLKQLNLVSQVAQLKQRLIE--QGFNVSFNVVLNALPAKVEGIAGLIiKEAVTNLL----RHSNTKNC-EINIEQTA 309
Cdd:COG2205   84 LSLELEPVDLAELLEEAVEELRPlaEEKGIRLELDLPPELPLVYADPELL-EQVLANLLdnaiKYSPPGGTiTISARREG 162

                        170
                 ....*....|..
gi 639316652 310 QQLLITVIDHGP 321
Cdd:COG2205  163 DGVRISVSDNGP 174
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
283-321 5.95e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 39.51  E-value: 5.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 639316652 283 LIIKEAVTNLLRHSN----TKNCEINIEQTAQQLLITVIDHGP 321
Cdd:COG2172   37 LAVSEAVTNAVRHAYggdpDGPVEVELELDPDGLEIEVRDEGP 79
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
92-321 8.61e-04

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 41.05  E-value: 8.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652  92 LFGFVAYIAGYSYSYRQRIYAAIAIIFTVLLSTYIGDIGKVQYFLGVALILCATLFSYGIAAKRESLYKKREQESANQLE 171
Cdd:COG0642   25 LLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 172 QlaAIAERERIARDL-HDILGHsLSSIALKAELANKL---NQGERYAQANSEIAQVADLARQLL----SDVRSAVSDLKQ 243
Cdd:COG0642  105 E--ANEAKSRFLANVsHELRTP-LTAIRGYLELLLEEldeEQREYLETILRSADRLLRLINDLLdlsrLEAGKLELEPEP 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 244 LNL---VSQVAQLKQRLIEQGfNVSFNVVLNALPAKVEGIAGLIiKEAVTNLL----RHSNTKNC-EINIEQTAQQLLIT 315
Cdd:COG0642  182 VDLaelLEEVVELFRPLAEEK-GIELELDLPDDLPTVRGDPDRL-RQVLLNLLsnaiKYTPEGGTvTVSVRREGDRVRIS 259


                 ....*.
gi 639316652 316 VIDHGP 321
Cdd:COG0642  260 VEDTGP 265
DUF3375 pfam11855
Protein of unknown function (DUF3375); This family of proteins are functionally ...
 169-259 3.04e-03

Protein of unknown function (DUF3375); This family of proteins are functionally uncharacterized. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.


Pssm-ID: 463373  Cd Length: 469  Bit Score: 39.55  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652  169 QLEQLAAIAE---RERIARDLHDILghslssiALKAELAnKLNQGERY----AQANSEIAQVADLARQLLSDVRSAVSDL 241
Cdd:pfam11855 124 ALRQLAEGTEpdpEERLAELEAEIA-------EIDAEID-RLRAGEVPelddTQALERAREILQLARELPADFRRVEDEF 195

                          90
                  ....*....|....*...
gi 639316652  242 KQLNlvsqvAQLKQRLIE 259
Cdd:pfam11855 196 RQLD-----RELRERIID 208
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 169-321 4.80e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 38.79  E-value: 4.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 169 QLEQLAAIAErerIARDL-HDIlGHSLSSIALKAE-LANKLNQgeryaqansEIAQVADLARQLLSDVRSAVSDLKQL-- 244
Cdd:COG5000  194 RAERLAAWGE---LARRIaHEI-KNPLTPIQLSAErLRRKLAD---------KLEEDREDLERALDTIIRQVDRLKRIvd 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 245 -------------------NLVSQVAQLkQRLIEQGFNVSFNVVLNALPAKVEGIAGLIiKEAVTNLLrhsntKNC---- 301
Cdd:COG5000  261 efldfarlpepqlepvdlnELLREVLAL-YEPALKEKDIRLELDLDPDLPEVLADRDQL-EQVLINLL-----KNAieai 333

                        170       180
                 ....*....|....*....|....*.
gi 639316652 302 ------EINIEQTAQQLLITVIDHGP 321
Cdd:COG5000  334 eeggeiEVSTRREDGRVRIEVSDNGP 359
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 282-363 8.84e-03

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 37.96  E-value: 8.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639316652 282 GLIIKEAVTNLLRH--SNTKNCEINI--EQTAQQLLITVIDHG----PCSTLNSGNGLnG---IKERAEQLNGSAAFTCG 350
Cdd:COG3920  401 GLILNELVTNALKHafLSGEGGRIRVswRREDGRLRLTVSDNGvglpEDVDPPARKGL-GlrlIRALVRQLGGTLELDRP 479

                         90
                 ....*....|...
gi 639316652 351 DNFTLKVVLPITA 363
Cdd:COG3920  480 EGTRVRITFPLAE 492
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 272-329 9.29e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 35.86  E-value: 9.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639316652 272 ALPAKVEGIAGLIIKEAVTNLLRHS----NTKNCEINIEQTAQQLLITVIDHG-----PCSTLNSGN 329
Cdd:cd16951   31 PVSSEVATAIGLVVNELLQNALKHAfsdrEGGTITIRSVVDGDYLRITVIDDGvglpqDEDWPNKGS 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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