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Conserved domains on  [gi|639320131|ref|WP_024595742|]
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MULTISPECIES: energy transducer TonB [Pseudoalteromonas]

Protein Classification

energy transducer TonB( domain architecture ID 11435256)

energy transducer TonB interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.)

PubMed:  8188372

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 308-362 2.82e-15

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 69.92  E-value: 2.82e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 639320131 308 VILEITVDTHGFVQSPKVISSEGSKAFEKSAIAAVKQWRYAPKFKNGKPVNATTQ 362
Cdd:COG0810   13 VTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKPAKQNGKPVRVKTV 67
 
Name Accession Description Interval E-value
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 308-362 2.82e-15

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 69.92  E-value: 2.82e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 639320131 308 VILEITVDTHGFVQSPKVISSEGSKAFEKSAIAAVKQWRYAPKFKNGKPVNATTQ 362
Cdd:COG0810   13 VTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKPAKQNGKPVRVKTV 67
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 293-368 4.58e-15

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 69.62  E-value: 4.58e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639320131  293 TEPIYPRGETKSHV--IVILEITVDTHGFVQSPKVISSEGSKAFEKSAIAAVKQWRYAPKFKNGKPVNATTQAELYFE 368
Cdd:pfam03544   1 PEPVYPEEARRRGIegTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKKWRFKPAPKNGQPVTVEITVPIRFK 78
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 308-368 5.79e-09

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 52.31  E-value: 5.79e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639320131  308 VILEITVDTHGFVQSPKVISSEGSKAFEKSAIAAVKQWRYAPKFKNGKPVNATTQAELYFE 368
Cdd:TIGR01352  12 VVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPPPPPGGVVAASVTIPVRFK 72
 
Name Accession Description Interval E-value
TonB COG0810
Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope ...
 308-362 2.82e-15

Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440572 [Multi-domain]  Cd Length: 70  Bit Score: 69.92  E-value: 2.82e-15
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 639320131 308 VILEITVDTHGFVQSPKVISSEGSKAFEKSAIAAVKQWRYAPKFKNGKPVNATTQ 362
Cdd:COG0810   13 VTVRFTIDADGRVTDVEVVKSSGHPLLDEAALRAVRRWRFKPAKQNGKPVRVKTV 67
TonB_C pfam03544
Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized ...
 293-368 4.58e-15

Gram-negative bacterial TonB protein C-terminal; The TonB_C domain is the well-characterized C-terminal region of the TonB receptor molecule. This protein is bound to an inner membrane-bound protein ExbB via a globular domain and has a flexible middle region that is likely to help in positioning the C-terminal domain into the iron-transporter barrel in the outer membrane. TonB_C interacts with the N-terminal TonB box of the outer membrane transporter that binds the Fe3+-siderophore complex. The barrel of the transporter, consisting of 22 beta-sheets and an inside plug, binds the iron complex in the barrel entrance.


Pssm-ID: 427361 [Multi-domain]  Cd Length: 79  Bit Score: 69.62  E-value: 4.58e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639320131  293 TEPIYPRGETKSHV--IVILEITVDTHGFVQSPKVISSEGSKAFEKSAIAAVKQWRYAPKFKNGKPVNATTQAELYFE 368
Cdd:pfam03544   1 PEPVYPEEARRRGIegTVVVEFLIDPDGNVTNVRVVKSSGYSILDEAALEAVKKWRFKPAPKNGQPVTVEITVPIRFK 78
tonB_Cterm TIGR01352
TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. ...
 308-368 5.79e-09

TonB family C-terminal domain; This model represents the C-terminal of TonB and is homologs. TonB is an energy-transducer for TonB-dependent receptors of Gram-negative bacteria. Most members are designated as TonB or TonB-related proteins, but a few represent the paralogous TolA protein. Several bacteria have up to four TonB paralogs. In nearly every case, a proline-rich repetive region is found N-terminal to this domain; these low-complexity regions are highly divergent and cannot readily be aligned. The region is suggested to help span the periplasm. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273570 [Multi-domain]  Cd Length: 74  Bit Score: 52.31  E-value: 5.79e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639320131  308 VILEITVDTHGFVQSPKVISSEGSKAFEKSAIAAVKQWRYAPKFKNGKPVNATTQAELYFE 368
Cdd:TIGR01352  12 VVVRFTVDPSGRVTSVSVLKSSGDRALDRAALEAVRKARFEPPPPPGGVVAASVTIPVRFK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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