|
Name |
Accession |
Description |
Interval |
E-value |
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
63-486 |
3.86e-119 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 359.10 E-value: 3.86e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 63 IVQAESGQRGYLLTEEADYLAPYYDAIGQIEAQTDHVKSLHSEIDGQAERIAQLLVLVDSKIKELKQTVNLALDDKERRA 142
Cdd:COG4251 90 ALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILA 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 143 MYVLNTHKGRKLYKQIREYVNEIQDRELLFKVSHFSKLAQIKNEAKITFAITAITSGLLIIGMFIMTRLNLRNAAQYRFE 222
Cdd:COG4251 170 LLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLI 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 223 LEKQNETLAIKVSERTQELTLYSDELSRSNRELEEFAFVASHDLQEPLRKIQAFSDRLETMFKDELGEKGMDYIGRMKNA 302
Cdd:COG4251 250 LVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLERIRDA 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 303 AQRMSNLINDLLEFSRITTRGKDFDDTNLNEVVADILSDLEIAIKESEAQIDVEDLPVIQADKSQMQQLFLNLLSNAVKF 382
Cdd:COG4251 330 AERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKY 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 383 RRPNISPHIKISYQDEDifssdhnthlSFQVITIEDNGIGFSQDYADKIFVPFQRLHGRSQYKGTGIGLSVCRRIVERHG 462
Cdd:COG4251 410 SRPGEPPRIEIGAEREG----------GEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHG 479
|
410 420
....*....|....*....|....
gi 639325553 463 GTITAQSKDGEGATFIIKLPVEAE 486
Cdd:COG4251 480 GRIWVESEPGEGATFYFTLPKAPA 503
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
246-486 |
2.43e-60 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 198.21 E-value: 2.43e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 246 DELSRSNRELEEFAFVASHDLQEPLRKIQAFSDRLETMfKDELGEKGMDYIGRMKNAAQRMSNLINDLLEFSRITTRGKD 325
Cdd:COG2205 7 EELEELERLKSEFLANVSHELRTPLTSILGAAELLLDE-EDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 326 FD--DTNLNEVVADILSDLEIAIKESEAQIDVE---DLPVIQADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDI 400
Cdd:COG2205 86 LElePVDLAELLEEAVEELRPLAEEKGIRLELDlppELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 401 fssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIK 480
Cdd:COG2205 166 ------------RISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVT 233
|
....*.
gi 639325553 481 LPVEAE 486
Cdd:COG2205 234 LPLAES 239
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
189-484 |
5.47e-59 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 197.44 E-value: 5.47e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 189 ITFAITAITSGLLIIGMFIMTRLNLRNAAQYRFELEKQNETLAIKVSERTQELTLYSDELSRSNRELEEFAFVASHDLQE 268
Cdd:COG0642 44 LLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 269 PLRKIQAFSDRLEtmfkDELGEKGMDYIGRMKNAAQRMSNLINDLLEFSRITTRGKDFD--DTNLNEVVADILSDLEIAI 346
Cdd:COG0642 124 PLTAIRGYLELLL----EELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEpePVDLAELLEEVVELFRPLA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 347 KESEAQIDVE---DLPVIQADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIfssdhnthlsfqVITIEDNGIGF 423
Cdd:COG0642 200 EEKGIELELDlpdDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRV------------RISVEDTGPGI 267
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639325553 424 SQDYADKIFVPFQRLHGRSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVE 484
Cdd:COG0642 268 PPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
112-486 |
1.64e-50 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 177.05 E-value: 1.64e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 112 RIAQLLVLVDSKIKELKQTVNLALDDKERRAMYVLNTHKGRKLYKQIREYVNEIQDRELLFKVSHFSKLAQIKNEAKITF 191
Cdd:COG5002 22 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 192 AITAITSGLLIIGMFIMTRLNLRNAAQYRFELEKQNETLAIKVSERTQELTLYSDELSRSNRELEEFAFVASHDLQEPLR 271
Cdd:COG5002 102 LILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLT 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 272 KIQAFSDRLETMFKDElGEKGMDYIGRMKNAAQRMSNLINDLLEFSRITTRGK--DFDDTNLNEVVADILSDLEIAIKES 349
Cdd:COG5002 182 SIRGYLELLLDGAADD-PEERREYLEIILEEAERLSRLVNDLLDLSRLESGELklEKEPVDLAELLEEVVEELRPLAEEK 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 350 EAQIDVE---DLPVIQADKSQMQQLFLNLLSNAVKFRRPNisPHIKISYQDEDifssdhnthlSFQVITIEDNGIGFSQD 426
Cdd:COG5002 261 GIELELDlpeDPLLVLGDPDRLEQVLTNLLDNAIKYTPEG--GTITVSLREED----------DQVRISVRDTGIGIPEE 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 639325553 427 YADKIFVPFQRL-HGRS-QYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVEAE 486
Cdd:COG5002 329 DLPRIFERFYRVdKSRSrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
200-483 |
1.83e-44 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 159.96 E-value: 1.83e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 200 LLIIGMFIMTRLNLRNAAQYRFELEKQNETLAIKVSERTQELTlysdELSRSNRELEEFAFVAS---------HDLQEPL 270
Cdd:COG4191 82 LGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEE----ELRELQEQLVQSEKLAAlgelaagiaHEINNPL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 271 RKIQAFSDRLETMFKDEL-GEKGMDYIGRMKNAAQRMSNLINDLLEFSRitTRGKDFDDTNLNEVVADILSDLEIAIKES 349
Cdd:COG4191 158 AAILGNAELLRRRLEDEPdPEELREALERILEGAERAAEIVRSLRAFSR--RDEEEREPVDLNELIDEALELLRPRLKAR 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 350 EAQIDVE---DLPVIQADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDifssdhnthlSFQVITIEDNGIGFSQD 426
Cdd:COG4191 236 GIEVELDlppDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGGRITISTRREG----------DYVVISVRDNGPGIPPE 305
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639325553 427 YADKIFVPFqrlhgrsqY------KGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:COG4191 306 VLERIFEPF--------FttkpvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
247-486 |
2.24e-41 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 153.19 E-value: 2.24e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 247 ELSRSNRE--LEEFAFVASHDLQEPLRKIQAFSDRLETMFKDELGEKG---MDYIGRMKNAAQRMSNLINDLLEFSRITT 321
Cdd:COG5000 191 ELLRAERLaaWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDRedlERALDTIIRQVDRLKRIVDEFLDFARLPE 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 322 RgkDFDDTNLNEVVADILSDLEIAIKESEAQIDVE---DLPVIQADKSQMQQLFLNLLSNAVK--FRRPNIspHIKISYQ 396
Cdd:COG5000 271 P--QLEPVDLNELLREVLALYEPALKEKDIRLELDldpDLPEVLADRDQLEQVLINLLKNAIEaiEEGGEI--EVSTRRE 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 397 DEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFqrlhgrsqY----KGTGIGLSVCRRIVERHGGTITAQSKDG 472
Cdd:COG5000 347 DGRV------------RIEVSDNGPGIPEEVLERIFEPF--------FttkpKGTGLGLAIVKKIVEEHGGTIELESRPG 406
|
250
....*....|....
gi 639325553 473 EGATFIIKLPVEAE 486
Cdd:COG5000 407 GGTTFTIRLPLAEE 420
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-482 |
5.60e-41 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 142.47 E-value: 5.60e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVKFRRPNISPHIKISYQDEDifssdhNTHlsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRSQYKGT 447
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVG------EEW----TFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGT 70
|
90 100 110
....*....|....*....|....*....|....*
gi 639325553 448 GIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16921 71 GVGLAIVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
264-486 |
3.08e-37 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 140.37 E-value: 3.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 264 HDLQEPLRKIQAFSDRLETMFKDElgeKGMDYIGRMKNAAQRMSNLINDLLEFSRitTRGKDFDDTNLNEVVADILsdlE 343
Cdd:COG3852 144 HEIRNPLTGIRGAAQLLERELPDD---ELREYTQLIIEEADRLNNLVDRLLSFSR--PRPPEREPVNLHEVLERVL---E 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 344 IAIKESEAQIDVE-----DLPVIQADKSQMQQLFLNLLSNAVKFRRPniSPHIKISYQDEDIFSSDHNTHLSFQVITIED 418
Cdd:COG3852 216 LLRAEAPKNIRIVrdydpSLPEVLGDPDQLIQVLLNLVRNAAEAMPE--GGTITIRTRVERQVTLGGLRPRLYVRIEVID 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639325553 419 NGIGFSQDYADKIFVPFQRlhGRSqyKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVEAE 486
Cdd:COG3852 294 NGPGIPEEILDRIFEPFFT--TKE--KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQA 357
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
363-484 |
8.37e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 120.45 E-value: 8.37e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 363 ADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRS 442
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHV------------EITVEDNGPGIPPEDLEKIFEPFFRTDKRS 68
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 639325553 443 Q-YKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVE 484
Cdd:smart00387 69 RkIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
234-484 |
3.09e-32 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 128.94 E-value: 3.09e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 234 VSER--TQELTLYSDELSRsnreLEEFAFVASHDLQEPLRKIQAFSDrletMFKDELGEKGMDYIGRMKNAAQRMSNLIN 311
Cdd:COG5809 251 ITERkkLEELLRKSEKLSV----VGELAAGIAHEIRNPLTSLKGFIQ----LLKDTIDEEQKTYLDIMLSELDRIESIIS 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 312 DLLEFSRIttRGKDFDDTNLNEVVADIlsdleIAIKESEA-----QIDVE---DLPVIQADKSQMQQLFLNLLSNAVKFR 383
Cdd:COG5809 323 EFLVLAKP--QAIKYEPKDLNTLIEEV-----IPLLQPQAllknvQIELEledDIPDILGDENQLKQVFINLLKNAIEAM 395
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 384 RPNISPHIKISYQDEDIFssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRlhgrSQYKGTGIGLSVCRRIVERHGG 463
Cdd:COG5809 396 PEGGNITIETKAEDDDKV-----------VISVTDEGCGIPEERLKKLGEPFYT----TKEKGTGLGLMVSYKIIEEHGG 460
|
250 260
....*....|....*....|.
gi 639325553 464 TITAQSKDGEGATFIIKLPVE 484
Cdd:COG5809 461 KITVESEVGKGTTFSITLPIK 481
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
235-483 |
9.67e-31 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 122.75 E-value: 9.67e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 235 SERTQELTLYSDELSRSNRELEEF-----------AFVAsHDLQEPLrkiQAFSDRLETM---FKDELGEKGMDYIGR-- 298
Cdd:PRK09303 121 GRYSQELLQLSDELFVLRQENETLleqlkfkdrvlAMLA-HDLRTPL---TAASLALETLelgQIDEDTELKPALIEQlq 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 299 --MKNAAQRMSNLINDLLEFSRitTRGKDFD----DTNLNEVVADILSDLEIAIKESEAQI--DV-EDLPVIQADKSQMQ 369
Cdd:PRK09303 197 dqARRQLEEIERLITDLLEVGR--TRWEALRfnpqKLDLGSLCQEVILELEKRWLAKSLEIqtDIpSDLPSVYADQERIR 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 370 QLFLNLLSNAVKFrrpniSP---HIKISyqdedIFssdHNTHLSFQViTIEDNGIGFSQDYADKIFVPFQRLHGRSQYKG 446
Cdd:PRK09303 275 QVLLNLLDNAIKY-----TPeggTITLS-----ML---HRTTQKVQV-SICDTGPGIPEEEQERIFEDRVRLPRDEGTEG 340
|
250 260 270
....*....|....*....|....*....|....*..
gi 639325553 447 TGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:PRK09303 341 YGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPV 377
|
|
| HK9-like_sensor |
cd19410 |
ligand binding sensor domain of Rhodopseudomonas palustris histidine kinase HK9 and similar ... |
54-169 |
1.11e-27 |
|
ligand binding sensor domain of Rhodopseudomonas palustris histidine kinase HK9 and similar proteins; The ligand binding sensor domain of Rhodopseudomonas palustris histidine kinase HK9 and similar proteins forms a homodimer and binds to an as yet uncharacterized ligand, most likely via the dimerization interface, a feature that appears to be conserved in this domain superfamily. This domain is similar to the extracellular sensory domain CHASE3, specifically found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognized by CHASE3 domains are not known at this time.
Pssm-ID: 438628 Cd Length: 125 Bit Score: 106.91 E-value: 1.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 54 TAIEKLHLSIVQAESGQRGYLLTEEADYLAPYYDAIGQIEAQTDHVKSLHSEIDGQAERIAQLLVLVDSKIKELKQTVNL 133
Cdd:cd19410 8 SELERLLSLLKDAETGQRGYLLTGDESYLEPYNAARARLPALLAELRELTADNPAQQARLDELEPLIDEKLAELARTIEL 87
|
90 100 110
....*....|....*....|....*....|....*.
gi 639325553 134 ALDDKERRAMYVLNTHKGRKLYKQIREYVNEIQDRE 169
Cdd:cd19410 88 RRAGGFEAALALVRSGRGKRLMDEIRALIAEMIAEE 123
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
363-484 |
1.61e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 106.30 E-value: 1.61e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 363 ADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEdifssdhnthlsfQVITIEDNGIGFSQDYADKIFVPFQRLHGRS 442
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGE-------------LTLTVEDNGIGIPPEDLPRIFEPFSTADKRG 67
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 639325553 443 QyKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVE 484
Cdd:pfam02518 68 G-GGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
368-483 |
2.12e-27 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 105.65 E-value: 2.12e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVKF-RRPNIspHIKISYQDEDifssDHNTHLSFQVitiEDNGIGFSQDYADKIFVPFQRL--HGRSQY 444
Cdd:cd16922 1 LRQILLNLLGNAIKFtEEGEV--TLRVSLEEEE----EDGVQLRFSV---EDTGIGIPEEQQARLFEPFSQAdsSTTRKY 71
|
90 100 110
....*....|....*....|....*....|....*....
gi 639325553 445 KGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:cd16922 72 GGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
259-486 |
2.63e-25 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 109.29 E-value: 2.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 259 AFVAsHDLQEPLRKIQAFSDRLETMFKDELGEKgmdYIGRMKNAAQRMSNLINDLLEFSRitTRGKDFDDTNLNEVVADI 338
Cdd:PRK11360 395 AGVA-HEIRNPLTAIRGYVQIWRQQTSDPPSQE---YLSVVLREVDRLNKVIDQLLEFSR--PRESQWQPVSLNALVEEV 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 339 LSDLEIAIKESEAQIDV---EDLPVIQADKSQMQQLFLNLLSNAVKfrrpNISPHIKISYQDEDIfSSDHnthlsfQVIT 415
Cdd:PRK11360 469 LQLFQTAGVQARVDFETeldNELPPIWADPELLKQVLLNILINAVQ----AISARGKIRIRTWQY-SDGQ------VAVS 537
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639325553 416 IEDNGIGFSQDYADKIFVPFQRlhgrSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVEAE 486
Cdd:PRK11360 538 IEDNGCGIDPELLKKIFDPFFT----TKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
196-485 |
2.67e-25 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 110.13 E-value: 2.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 196 ITSGLLIIGMFIMTRLNLRnaaqyrfEL---EKQN--ETLAIKVSERTQELTL-YSDELSRSNRELEEF--AFVA--SHD 265
Cdd:PRK10490 602 LKSAQKTYGLLAVEPGNLR-------QLmipEQQRllETFTLLIANALERLTLtASEEQARLASEREQLrnALLAalSHD 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 266 LQEPLRKI--QAfsdrlETMFKDeLGEKGMDYIGRMKNAAQRMSN---LINDLLEFSRITTRGkdfddTNLN-------E 333
Cdd:PRK10490 675 LRTPLTVLfgQA-----EILTLD-LASEGSPHARQASEIRQQVLNttrLVNNLLDMARIQSGG-----FNLRkewltleE 743
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 334 VVADILSDLEIAIKESEAQIDV-EDLPVIQADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIFssdhnthlsfq 412
Cdd:PRK10490 744 VVGSALQMLEPGLSGHPINLSLpEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQ----------- 812
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639325553 413 vITIEDNGIGFSQDYADKIFVPFQRLHGRSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVEA 485
Cdd:PRK10490 813 -LDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLET 884
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
223-493 |
2.42e-22 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 100.87 E-value: 2.42e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 223 LEKQNETLAIKVSERTQELTLYSDELSRSNRELEEFAFVASHDLQEPLRKIQAFSDRLETmfkDELGEKGMDYIGRMKNA 302
Cdd:PRK15347 366 LNEQYDTLENKVAERTQALAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQN---TPLTAEQMDLADTARQC 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 303 AQRMSNLINDLLEFSRITTrgkdfDDTNLNEVVADILSDLEIAIK--ESEAQ--------IDVEDLP-VIQADKSQMQQL 371
Cdd:PRK15347 443 TLSLLAIINNLLDFSRIES-----GQMTLSLEETALLPLLDQAMLtiQGPAQsksltlrtFVGAHVPlYLHLDSLRLRQI 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 372 FLNLLSNAVKFRRP-NISPHIKIsyqdedifssdHNTHLSFqviTIEDNGIGFSQDYADKIFVPFQRLHGRSQykGTGIG 450
Cdd:PRK15347 518 LVNLLGNAVKFTETgGIRLRVKR-----------HEQQLCF---TVEDTGCGIDIQQQQQIFTPFYQADTHSQ--GTGLG 581
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 639325553 451 LSVCRRIVERHGGTITAQSKDGEGATFIIKLPVE--AELFTLQGE 493
Cdd:PRK15347 582 LTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLNeyAPPEPLKGE 626
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
234-483 |
8.30e-22 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 99.24 E-value: 8.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 234 VSERTQeltlYSDELSRSNRELEEFAFVASHDLQEPLRKIQAFSdrleTMFKD-ELGEKGMDYIGRMKNAAQRMSNLIND 312
Cdd:PRK11091 266 ITERKR----YQDALEKASRDKTTFISTISHELRTPLNGIVGLS----RILLDtELTAEQRKYLKTIHVSAITLGNIFND 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 313 LLEFSRITTRGKDFDDTNLNevVADILSDLE----IAIKESEAQIDVE---DLP-VIQADKSQMQQLFLNLLSNAVKFRR 384
Cdd:PRK11091 338 IIDMDKMERRKLQLDNQPID--FTDFLADLEnlsgLQAEQKGLRFDLEpllPLPhKVITDGTRLRQILWNLISNAVKFTQ 415
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 385 PNiSPHIKISYQDEDifssdhntHLSFQVitiEDNGIGFSQDYADKIFVPF---QRLHGRSQYKGTGIGLSVCRRIVERH 461
Cdd:PRK11091 416 QG-GVTVRVRYEEGD--------MLTFEV---EDSGIGIPEDELDKIFAMYyqvKDSHGGKPATGTGIGLAVSKRLAQAM 483
|
250 260
....*....|....*....|..
gi 639325553 462 GGTITAQSKDGEGATFIIKLPV 483
Cdd:PRK11091 484 GGDITVTSEEGKGSCFTLTIHA 505
|
|
| CHASE3 |
pfam05227 |
CHASE3 domain; CHASE3 is an extracellular sensory domain, which is present in various classes ... |
54-169 |
9.73e-22 |
|
CHASE3 domain; CHASE3 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria. Specifically, CHASE3 domains are found in histidine kinases, adenylate cyclases, methyl-accepting chemotaxis proteins and predicted diguanylate cyclases/phosphodiesterases. This domain recognizes pyrene (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 428379 Cd Length: 138 Bit Score: 90.83 E-value: 9.73e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 54 TAIEKLHLSIVQAESGQRGYLLTEEADYLAPYYDAIGQIEAQTDHVKSLHSEIDGQAERIAQLLVLVDSKIKELKQTVNL 133
Cdd:pfam05227 13 AALEQLLSALVDAETGQRGYLLTGDESFLEPYEEARAAIPELLARLRALTADNPEQQQRLERLEALIEQKLAELEPTIAL 92
|
90 100 110
....*....|....*....|....*....|....*.
gi 639325553 134 ALDDKERRAMYVLNTHKGRKLYKQIREYVNEIQDRE 169
Cdd:pfam05227 93 RREGGLEAALALVRSDEGKRLMDAIRALLAEMKAEE 128
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
294-494 |
2.95e-20 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 94.36 E-value: 2.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 294 DYIGRMKNAAQRMSNLINDLLEFSRITTRG-KDFDdtnLNEVVADILSDLEIAIKeSEAQIDVEDLP---VIQADKSQMQ 369
Cdd:PRK13837 487 RYIDEIISAGARARLIIDQILAFGRKGERNtKPFD---LSELVTEIAPLLRVSLP-PGVELDFDQDQepaVVEGNPAELQ 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 370 QLFLNLLSNAVKFRRPNISPHIKISYQD---EDIFSSDHNTHLSFQVITIEDNGIGFSQDYADKIFVPFqrLHGRSQykG 446
Cdd:PRK13837 563 QVLMNLCSNAAQAMDGAGRVDISLSRAKlraPKVLSHGVLPPGRYVLLRVSDTGAGIDEAVLPHIFEPF--FTTRAG--G 638
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 639325553 447 TGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP------VEAELFTLQGEA 494
Cdd:PRK13837 639 TGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPpsskvpVAPQAFFGPGPL 692
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
218-482 |
3.17e-20 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 93.98 E-value: 3.17e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 218 QYRFELEKQNETLAIKVSERTQEltlySDELSRSNRELEEFAFVA---------SHDLQEPLRKIQAFSDRLETMFKDEL 288
Cdd:COG4192 391 VFRDQAIEKTQELETEIEERKRI----EKNLRQTQDELIQAAKMAvvgqtmtslAHELNQPLNAMSMYLFSAKKALEQEN 466
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 289 GEKGMDYIGRMKNAAQRMSNLINDLLEFSRitTRGKDFDDTNLNEVVADILSDLEIAIKESEAQIDVEDLPVIQADKSQM 368
Cdd:COG4192 467 YAQLPTSLDKIEGLIERMDKIIKSLRQFSR--KSDTPLQPVDLRQVIEQAWELVESRAKPQQITLHIPDDLMVQGDQVLL 544
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 369 QQLFLNLLSNAvkFRRPNISPHIKIsyqdeDIFSSDHNthlsfQVITIEDNGIGFsqDYADKIFVPFQrlhgRSQYKGTG 448
Cdd:COG4192 545 EQVLVNLLVNA--LDAVATQPQISV-----DLLSNAEN-----LRVAISDNGNGW--PLVDKLFTPFT----TTKEVGLG 606
|
250 260 270
....*....|....*....|....*....|....
gi 639325553 449 IGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:COG4192 607 LGLSICRSIMQQFGGDLYLASTLERGAMVILEFN 640
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
233-486 |
9.16e-20 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 91.77 E-value: 9.16e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 233 KVSERTQELtlySDELSRSNR--ELEEFAFVASHDLQEPLRKIQAFSdrleTMFKDELGEKGMDY--IGRMKNAAQRMSN 308
Cdd:PRK10364 216 RYLRSRQLL---QDEMKRKEKlvALGHLAAGVAHEIRNPLSSIKGLA----KYFAERAPAGGEAHqlAQVMAKEADRLNR 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 309 LINDLLEFSRITTRGkdFDDTNLNEVVADILSDLEIAIKESEAQIDV---EDLPVIQADKSQMQQLFLNLLSNAVKfrrp 385
Cdd:PRK10364 289 VVSELLELVKPTHLA--LQAVDLNDLINHSLQLVSQDANSREIQLRFtanDTLPEIQADPDRLTQVLLNLYLNAIQ---- 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 386 NISPHIKISYQdedifSSDHNTHLSfqvITIEDNGIGFSQDYADKIFVPFQRLHGrsqyKGTGIGLSVCRRIVERHGGTI 465
Cdd:PRK10364 363 AIGQHGVISVT-----ASESGAGVK---ISVTDSGKGIAADQLEAIFTPYFTTKA----EGTGLGLAVVHNIVEQHGGTI 430
|
250 260
....*....|....*....|.
gi 639325553 466 TAQSKDGEGATFIIKLPVEAE 486
Cdd:PRK10364 431 QVASQEGKGATFTLWLPVNIT 451
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
234-483 |
2.11e-19 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 90.95 E-value: 2.11e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 234 VSERTQ--ELTLYSDELSRsnreLEEFAFVASHDLQEPLRKIQAFSdrleTMFKDELGEKGmDYIGRMKNAAQRMSNLIN 311
Cdd:COG5805 268 ITEKKEaeELMARSEKLSI----AGQLAAGIAHEIRNPLTSIKGFL----QLLQPGIEDKE-EYFDIMLSELDRIESIIS 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 312 DLLEFSRitTRGKDFDDTNLNEVVADILSDLEIAIKESEAQIDV---EDLPVIQADKSQMQQLFLNLLSNAVKFRRPNIS 388
Cdd:COG5805 339 EFLALAK--PQAVNKEKENINELIQDVVTLLETEAILHNIQIRLellDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGT 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 389 PHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLhgrsQYKGTGIGLSVCRRIVERHGGTITAQ 468
Cdd:COG5805 417 ITIHTEEEDNSV------------IIRVIDEGIGIPEERLKKLGEPFFTT----KEKGTGLGLMVSYKIIENHNGTIDID 480
|
250
....*....|....*
gi 639325553 469 SKDGEGATFIIKLPV 483
Cdd:COG5805 481 SKVGKGTTFTITLPL 495
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-483 |
3.61e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 79.77 E-value: 3.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 366 SQMQQLFLNLLSNAVKfrrpNISPHIKISYQdedifSSDHNTHlsfQVITIEDNGIGFSQDYADKIFVPF--QRLHGrsq 443
Cdd:cd16943 2 SQLNQVLLNLLVNAAQ----AMEGRGRITIR-----TWAHVDQ---VLIEVEDTGSGIDPEILGRIFDPFftTKPVG--- 66
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 639325553 444 yKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:cd16943 67 -EGTGLGLSLSYRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| CHASE3 |
COG5278 |
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms]; |
18-371 |
3.79e-18 |
|
Extracytoplasmic sensor domain CHASE3 (specificity unknown) [Signal transduction mechanisms];
Pssm-ID: 444089 [Multi-domain] Cd Length: 530 Bit Score: 87.27 E-value: 3.79e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 18 MVVVLGIIVGNAFLALNTIQGLTQTQKSLDNTSMLTTAIEKLHLSIVQAESGQRGYLLTEEADYLAPYYDAIGQIEAQTD 97
Cdd:COG5278 14 FALALLLLLVLGVLSYLSLNRLREASEWVEHTYEVLRALEELLSALLDAETGQRGYLLTGDESFLEPYEEARAEIDELLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 98 HVKSLHSEIDGQAERIAQLLVLVDSKIKELKQTVNLALDDKERRAMYVLNTHKGRKLYKQIREyvnEIQDRELLFKVSHF 177
Cdd:COG5278 94 ELRSLTADNPEQQARLDELEALIDQWLAELEQVIALRRAGGLEAALALVRSGEGKALMDEIRA---RLLLLALALAALLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 178 SKLAQIKNEAKITFAITAITSGLLIIGMFIMTRLNLRNAAQYRFELEKQNETLAIKVSERTQELTLYSDELSRSNRELEE 257
Cdd:COG5278 171 AAAALLLLLLALAALLALAELLLLALARALAALLLLLLLEAELAAAAALLAAAAALAALAALELLAALALALALLLAALL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 258 FAFVASHDLQEPLRKIQAFSDRLETMFKDELGEKGMDYIGRMKNAAQRMSNLINDLLEFSRITTRGKDFDDTNLNEVVAD 337
Cdd:COG5278 251 LALLAALALAALLAAALLALAALLLALAAAAALAAAAALELAAAEALALAELELELLLAAAAAAAAAAAAAAAALAALLA 330
|
330 340 350
....*....|....*....|....*....|....
gi 639325553 338 ILSDLEIAIKESEAQIDVEDLPVIQADKSQMQQL 371
Cdd:COG5278 331 LALATALAAAAAALALLAALLAEAAAAAAEEAEA 364
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
260-484 |
3.32e-17 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 84.90 E-value: 3.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 260 FVA--SHDLQEPLRKIQAFSdRLetMFKDELGEKGMDYIGRMKNAAQRMSNLINDLLEFSRITTrGK--------DFDDT 329
Cdd:PRK11107 296 FLAnmSHELRTPLNGVIGFT-RQ--TLKTPLTPTQRDYLQTIERSANNLLAIINDILDFSKLEA-GKlvlenipfSLRET 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 330 nLNEVVAdILS------DLEIAIKeseaqIDvEDLP--VIqADKSQMQQLFLNLLSNAVKF-RRPNIspHIKISYQDedi 400
Cdd:PRK11107 372 -LDEVVT-LLAhsahekGLELTLN-----ID-PDVPdnVI-GDPLRLQQIITNLVGNAIKFtESGNI--DILVELRA--- 437
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 401 fSSDHNTHLSFQVItieDNGIGFSQDYADKIFVPFQ-------RLHGrsqykGTGIGLSVCRRIVERHGGTITAQSKDGE 473
Cdd:PRK11107 438 -LSNTKVQLEVQIR---DTGIGISERQQSQLFQAFRqadasisRRHG-----GTGLGLVITQKLVNEMGGDISFHSQPNR 508
|
250
....*....|.
gi 639325553 474 GATFIIKLPVE 484
Cdd:PRK11107 509 GSTFWFHLPLD 519
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
223-483 |
1.22e-16 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 83.03 E-value: 1.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 223 LEKQNETLAIKVSERTQELTLYSDELSRSNRELE-----EFAFVA--SHDLQEPLRKIQAFSDRLEtmfKDELGEKGMDY 295
Cdd:PRK11466 405 LNRHREQLAAQVKARTAELQELVIEHRQARAEAEkasqaKSAFLAamSHEIRTPLYGILGTAQLLA---DNPALNAQRDD 481
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 296 IGRMKNAAQRMSNLINDLLEFSRITTRGKDfddTNLNE-------VVADILSDLEIAIKESEAQID---VEDLPV-IQAD 364
Cdd:PRK11466 482 LRAITDSGESLLTILNDILDYSAIEAGGKN---VSVSDepfeprpLLESTLQLMSGRVKGRPIRLAtdiADDLPTaLMGD 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 365 KSQMQQLFLNLLSNAVKFRRPNispHIKISYQDEDifssdhnTHLsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRSqy 444
Cdd:PRK11466 559 PRRIRQVITNLLSNALRFTDEG---SIVLRSRTDG-------EQW---LVEVEDSGCGIDPAKLAEIFQPFVQVSGKR-- 623
|
250 260 270
....*....|....*....|....*....|....*....
gi 639325553 445 KGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:PRK11466 624 GGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-482 |
1.88e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 74.88 E-value: 1.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 364 DKSQMQQLFLNLLSNAVKF--RRPNISPHIKISY---QDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRl 438
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAieGRPSDVGEVRIRVeadQDGRI------------VLIVCDNGKGFPREMRHRATEPYVT- 67
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 639325553 439 hgrSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16944 68 ---TRPKGTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-482 |
7.20e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 70.50 E-value: 7.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVK-FRRPNISPH---IKISYQDEDifssdhnthlsFQVITIEDNGIGFSQDYADKIFVPFQRlhgrSQ 443
Cdd:cd16920 1 IQQVLINLVRNGIEaMSEGGCERReltIRTSPADDR-----------AVTISVKDTGPGIAEEVAGQLFDPFYT----TK 65
|
90 100 110
....*....|....*....|....*....|....*....
gi 639325553 444 YKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16920 66 SEGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
290-486 |
7.87e-15 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 76.04 E-value: 7.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 290 EKGMDYIGRMKNAAQRMSNLINDLLEfsrittrgkdfddtnlNEVVADILSDLEIAIKESEAQIDVE---DLPVIQADKS 366
Cdd:COG3290 217 DEALEYIDEISEELQELIDSLLSRIG----------------NPVLAALLLGKAARARERGIDLTIDidsDLPDLPLSDT 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 367 QMQQLFLNLLSNAV------KFRRPNIspHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPfqrlhG 440
Cdd:COG3290 281 DLVTILGNLLDNAIeaveklPEEERRV--ELSIRDDGDEL------------VIEVEDSGPGIPEELLEKIFER-----G 341
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 639325553 441 RS--QYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVEAE 486
Cdd:COG3290 342 FStkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
374-482 |
8.58e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 70.05 E-value: 8.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 374 NLLSNAVKFRRPNIspHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRSQYK--GTGIGL 451
Cdd:cd16949 7 NVLRNALRYSPSKI--LLDISQDGDQW------------TITITDDGPGVPEDQLEQIFLPFYRVDSARDREsgGTGLGL 72
|
90 100 110
....*....|....*....|....*....|.
gi 639325553 452 SVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16949 73 AIAERAIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
258-482 |
8.98e-15 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 76.20 E-value: 8.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 258 FAFVaSHDLQEPLRKIQAFsdrLEtMFKDELGEKGM--DYIGRMKNAAQRMSNLINDLLEFSRITTRgkdfDDTNLNEVV 335
Cdd:PRK11006 208 FANV-SHELRTPLTVLQGY---LE-MMQDQPLEGALreKALHTMREQTQRMEGLVKQLLTLSKIEAA----PTIDLNEKV 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 336 aDILSDLEIAIKESEA--------QIDVEDLPVIQADKSQMQQLFLNLLSNAVKFRRPNIspHIKISYQdedifSSDHNT 407
Cdd:PRK11006 279 -DVPMMLRVLEREAQTlsqgkhtiTFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGT--HITVRWQ-----RVPQGA 350
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639325553 408 HLSfqvitIEDNGIGFSQDYADKIFVPFQRL-HGRS-QYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:PRK11006 351 EFS-----VEDNGPGIAPEHIPRLTERFYRVdKARSrQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
364-482 |
2.72e-14 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 69.06 E-value: 2.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 364 DKSQMQQLFLNLLSNAVKFrrpniSP---HIKISYQdedifssdhNTHLSFQVITIEDNGIGFSQDYADKIFVPFQRLHG 440
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKF-----TPdggRIRCILE---------KFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDG 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 639325553 441 RSQYK--GTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16925 67 SSTRAhgGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
350-481 |
7.91e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 67.92 E-value: 7.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 350 EAQIDVEDLPVI-QADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIFssdhnthlsfqvITIEDNGIGFSQDYA 428
Cdd:cd16947 2 QVEINIPDRPIYaNANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVY------------IDIWDKGKGISETEK 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 639325553 429 DKIFvpfQRLH-----GRSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKL 481
Cdd:cd16947 70 DHVF---ERLYtledsRNSAKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
374-482 |
9.03e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 67.31 E-value: 9.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 374 NLLSNAVKFRRPNISPHIKISyqdedIFSSDHNthlSFQVITIEDNGIGFSQDYADKIFVpfqrlHGRS--QYKGTGIGL 451
Cdd:cd16915 7 NLIDNALDALAATGAPNKQVE-----VFLRDEG---DDLVIEVRDTGPGIAPELRDKVFE-----RGVStkGQGERGIGL 73
|
90 100 110
....*....|....*....|....*....|.
gi 639325553 452 SVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16915 74 ALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
304-482 |
2.09e-13 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 72.04 E-value: 2.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 304 QRMSNLINDLLEFSRiTTRGK---DFDDTNLNEVVADILSDLEIAIKESEAQIDVEDLPVIQADKSQMQQLFLNLLSNAV 380
Cdd:TIGR01386 288 ERLSRMVSDMLFLAR-ADNGQlalERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNAL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 381 KFRRPNISPHIKISyQDEDIFSsdhnthlsfqvITIEDNGIGFSQDYADKIFVPFQRLHGRSQYK--GTGIGLSVCRRIV 458
Cdd:TIGR01386 367 RHTPDGGTITVRIE-RRSDEVR-----------VSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSgeGTGLGLAIVRSIM 434
|
170 180
....*....|....*....|....
gi 639325553 459 ERHGGTITAQSKDGEgATFIIKLP 482
Cdd:TIGR01386 435 EAHGGRASAESPDGK-TRFILRFP 457
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-481 |
2.73e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 65.94 E-value: 2.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAV----KFRRPNISphIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFqrLHGRSQ 443
Cdd:cd16976 1 IQQVLMNLLQNALdamgKVENPRIR--IAARRLGGRL------------VLVVRDNGPGIAEEHLSRVFDPF--FTTKPV 64
|
90 100 110
....*....|....*....|....*....|....*...
gi 639325553 444 YKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKL 481
Cdd:cd16976 65 GKGTGLGLSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-482 |
3.40e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 65.88 E-value: 3.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIFSSDHNTHLSFQViTIEDNGIGFSQDYADKIFVPFqrLHGRSQykGT 447
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGGEIILRTRTQRQVTLGHPRHRLALRV-SVIDNGPGIPPDLQDTIFYPM--VSGREN--GT 75
|
90 100 110
....*....|....*....|....*....|....*
gi 639325553 448 GIGLSVCRRIVERHGGTITAQSKDGEgATFIIKLP 482
Cdd:cd16918 76 GLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-474 |
3.68e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 65.89 E-value: 3.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 361 IQADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDifssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHG 440
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGA-------------VIRVEDNGPGIDEEELEALFERFYRSDG 73
|
90 100 110
....*....|....*....|....*....|....
gi 639325553 441 RSqYKGTGIGLSVCRRIVERHGGTITAQSKDGEG 474
Cdd:cd16940 74 QN-YGGSGLGLSIVKRIVELHGGQIFLGNAQGGG 106
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
226-482 |
1.20e-12 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 70.39 E-value: 1.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 226 QNETLAI----------KVSERTQELTLYSDELSRSNReleefAFVA--SHDLQEPLRKIQAFSDRLETMfkdELGEKGM 293
Cdd:PRK10841 411 RNENVAIcvlvdvsarvKMEESLQEMAQAAEQASQSKS-----MFLAtvSHELRTPLYGIIGNLDLLQTK---ELPKGVD 482
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 294 DYIGRMKNAAQRMSNLINDLLEFSRITTRG-----KDFddtNLNEVVADILSD-LEIAIKESEAQ---IDvEDLPV-IQA 363
Cdd:PRK10841 483 RLVTAMNNSSSLLLKIISDILDFSKIESEQlkiepREF---SPREVINHITANyLPLVVKKRLGLycfIE-PDVPVaLNG 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 364 DKSQMQQLFLNLLSNAVKFRRP-NISPHIkisYQDEDifssdhntHLSFQVitiEDNGIGFSQDYADKIFVPF-QRLHG- 440
Cdd:PRK10841 559 DPMRLQQVISNLLSNAIKFTDTgCIVLHV---RVDGD--------YLSFRV---RDTGVGIPAKEVVRLFDPFfQVGTGv 624
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 639325553 441 RSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:PRK10841 625 QRNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIP 666
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
240-483 |
1.42e-12 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 69.49 E-value: 1.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 240 ELTLYSDELSRSNRELEEFAFVAS------HDLQEPLRKIQAFSdrletmfkdELGEKGMD------YIGRMKNAAQRMS 307
Cdd:PRK11100 235 ELRELAQALESMRVKLEGKAYVEQyvqtltHELKSPLAAIRGAA---------ELLQEDPPpedrarFTGNILTQSARLQ 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 308 NLINDLLEFSRITTRG--KDFDDTNLNEVVADILSDLEIAI--KESEAQIDVEDLpVIQADKSQMQQLFLNLLSNAVKFR 383
Cdd:PRK11100 306 QLIDRLLELARLEQRQelEVLEPVALAALLEELVEAREAQAaaKGITLRLRPDDA-RVLGDPFLLRQALGNLLDNAIDFS 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 384 RPNISPHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSqDYA-DKIFVPF---QRLHGrsQYKGTGIGLSVCRRIVE 459
Cdd:PRK11100 385 PEGGTITLSAEVDGEQV------------ALSVEDQGPGIP-DYAlPRIFERFyslPRPAN--GRKSTGLGLAFVREVAR 449
|
250 260
....*....|....*....|....
gi 639325553 460 RHGGTITAQSKDGEGATFIIKLPV 483
Cdd:PRK11100 450 LHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-482 |
1.43e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 64.02 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 364 DKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHG--R 441
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEV------------RLDVEDSAPGVSDDQLARLFERFYRVESsrN 68
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 639325553 442 SQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16946 69 RASGGSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
257-484 |
5.26e-12 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 68.61 E-value: 5.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 257 EFAFVASHDLQEPLRKIQAFsdrLETMFKDELG-EKGMDYIGRMKNAAQRMSNLINDLLEFSRITTRGKDFDD--TNLNE 333
Cdd:PRK09959 714 QFLATMSHEIRTPISSIMGF---LELLSGSGLSkEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPqwVDIPT 790
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 334 VVADILSDL-EIAIKESEAQIDVEDLP---VIQADKSQMQQLFLNLLSNAVKFrrpNISPHIKISyqdEDIFSSDHNtHL 409
Cdd:PRK09959 791 LVQNTCHSFgAIAASKSIALSCSSTFPdhyLVKIDPQAFKQVLSNLLSNALKF---TTEGAVKIT---TSLGHIDDN-HA 863
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639325553 410 SFQvITIEDNGIGFSQDYADKIFVPFQRLHGRSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVE 484
Cdd:PRK09959 864 VIK-MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVE 937
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-482 |
1.06e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 61.25 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRSQYKGT 447
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVV------------NIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGA 68
|
90 100 110
....*....|....*....|....*....|....*
gi 639325553 448 GIGLSVCRRIVERHGGTITAQSkDGEGATFIIKLP 482
Cdd:cd16923 69 GLGLSIAKAIIELHGGSASAEY-DDNHDLFKVRLP 102
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
263-482 |
1.68e-11 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 66.11 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 263 SHDLQEPLRKIQafsdrLET-MFKDELGEKgmDYIGRMKNAAQRMSNLINDLLEFSRIT-----TRgkdfDDTNLNEVVA 336
Cdd:PRK09470 251 SHELRTPLTRLQ-----LATaLLRRRQGES--KELERIETEAQRLDSMINDLLVLSRNQqknhlER----ETFKANSLWS 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 337 DILSDLEIAIKESEAQIDVEDLP---VIQADKSQMQQLFLNLLSNAVKFRRPNISPHIKIsyQDEDIFssdhnthlsfqv 413
Cdd:PRK09470 320 EVLEDAKFEAEQMGKSLTVSAPPgpwPINGNPNALASALENIVRNALRYSHTKIEVAFSV--DKDGLT------------ 385
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639325553 414 ITIEDNGIGFSQDYADKIFVPFQRL-HGRS-QYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:PRK09470 386 ITVDDDGPGVPEEEREQIFRPFYRVdEARDrESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-483 |
1.71e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 60.91 E-value: 1.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVKFRRPNISphikISYQDEDifssdhnthlSFQVITIEDNGIGFSQDYADKIFVPFQRLH-GRS-QYK 445
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVR----IALLVSG----------GRLTLIVEDDGPGIPAAARERVFEPFVRLDpSRDrATG 66
|
90 100 110
....*....|....*....|....*....|....*...
gi 639325553 446 GTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:cd16939 67 GFGLGLAIVHRVALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
337-487 |
1.93e-11 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 65.81 E-value: 1.93e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 337 DILSDLEIAI---------KESEAQIDVEDLPVIQADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIfssdhnt 407
Cdd:PRK10549 313 DLVPLLEVAGgafrerfasRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTL------- 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 408 hlsfqVITIEDNGIGFSQDYADKIFVPFQRLHG-RSQYKG-TGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVEA 485
Cdd:PRK10549 386 -----RLTFADSAPGVSDEQLQKLFERFYRTEGsRNRASGgSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 460
|
..
gi 639325553 486 EL 487
Cdd:PRK10549 461 DL 462
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
370-482 |
3.67e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 59.89 E-value: 3.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 370 QLFLNLLSNAVKFRrPNISPHIKISYQDEDifssdhnthlSFQVITIEDNGIGFSQDYADKIFVPF--QRLHGRSQYKGT 447
Cdd:cd16953 3 QVLRNLIGNAISFS-PPDTGRITVSAMPTG----------KMVTISVEDEGPGIPQEKLESIFDRFytERPANEAFGQHS 71
|
90 100 110
....*....|....*....|....*....|....*....
gi 639325553 448 GIGLSVCRRIVERHGGTITA----QSKDGEGATFIIKLP 482
Cdd:cd16953 72 GLGLSISRQIIEAHGGISVAenhnQPGQVIGARFTVQLP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-482 |
4.22e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 59.38 E-value: 4.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVKFRRPNISPHikiSYQDEDIfssdhnthLSFQVitiEDNGIGFSQDYADKIFVPFQRLHGRSQYKGT 447
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVS---SDGEGNR--------TRIQV---LDNGPGIAPEEVDELFQPFYRGDNARGTSGT 66
|
90 100 110
....*....|....*....|....*....|....*
gi 639325553 448 GIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16950 67 GLGLAIVQRISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-482 |
5.15e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 59.52 E-value: 5.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 372 FLNLLSNAVKFRRPniSPHIKISYQDEDifssdHNTHLSfqvitIEDNGIGFSQDYADKIFVPFQRLH--GRSQYKGTGI 449
Cdd:cd16952 5 FSNLVSNAVKYTPP--SDTITVRWSQEE-----SGARLS-----VEDTGPGIPPEHIPRLTERFYRVDieRCRNTGGTGL 72
|
90 100 110
....*....|....*....|....*....|...
gi 639325553 450 GLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16952 73 GLAIVKHVMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
248-466 |
9.62e-11 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 63.78 E-value: 9.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 248 LSRSNRELEE-----FAFVaSHDLQEPLRKIqafsdRLETmfkdELGEKGMDYIGR-MKNAAQRMSNLINDLLEFSRiTT 321
Cdd:PRK09467 218 MAAGIKQLEDdrtllMAGV-SHDLRTPLTRI-----RLAT----EMMSEEDGYLAEsINKDIEECNAIIEQFIDYLR-TG 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 322 RGKDFDDTNLNEVVADILSdleiAIKESEAQIDVE--DLPV-IQADKSQMQQLFLNLLSNAvkFRRPNisPHIKISyqde 398
Cdd:PRK09467 287 QEMPMEMADLNALLGEVIA----AESGYEREIETAlqPGPIeVPMNPIAIKRALANLVVNA--ARYGN--GWIKVS---- 354
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639325553 399 difsSDHNTHLSFqvITIEDNGIGFSQDYADKIFVPFQRlhG---RSQyKGTGIGLSVCRRIVERHGGTIT 466
Cdd:PRK09467 355 ----SGTEGKRAW--FQVEDDGPGIPPEQLKHLFQPFTR--GdsaRGS-SGTGLGLAIVKRIVDQHNGKVE 416
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
263-483 |
1.28e-09 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 60.45 E-value: 1.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 263 SHDLQEPLRKIQAFSDRLETMFKDELGEKG-MDY-IGRMKNAAQRMSNLINDLLEFSRITT-RGKDFddtNLNEVVaDIL 339
Cdd:PRK13557 171 AHDFNNLLQVMSGYLDVIQAALSHPDADRGrMARsVENIRAAAERAATLTQQLLAFARKQRlEGRVL---NLNGLV-SGM 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 340 SDL-------EIAIKESEAqidvEDLPVIQADKSQMQQLFLNLLSNAvkfrR---PNiSPHIKISYQDEDIfsSDHNTHL 409
Cdd:PRK13557 247 GELaertlgdAVTIETDLA----PDLWNCRIDPTQAEVALLNVLINA----RdamPE-GGRVTIRTRNVEI--EDEDLAM 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 410 SFQV-------ITIEDNGIGFSQDYADKIFVPFqrLHGRSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:PRK13557 316 YHGLppgryvsIAVTDTGSGMPPEILARVMDPF--FTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
.
gi 639325553 483 V 483
Cdd:PRK13557 394 A 394
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
411-482 |
2.79e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 54.69 E-value: 2.79e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 639325553 411 FQVITIEDNGIGFSQDYADKIFVPFQRLHGRSqyKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16919 47 YVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVG--KGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
263-483 |
3.36e-09 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 58.55 E-value: 3.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 263 SHDLQEPLRKIQAFSDRLETMFKD-ELGEkgmdYIGRMKNAAQRMSNLINDLLEFSRITTRGKDfddtNLNEVVADILSD 341
Cdd:PRK11073 138 AHEIKNPLGGLRGAAQLLSKALPDpALTE----YTKVIIEQADRLRNLVDRLLGPQRPGTHVTE----SIHKVAERVVQL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 342 LEIaikESEAQIDVE-----DLPVIQADKSQMQQLFLNLLSNAVKFRRPnisPHIKISYQdedifssdhnTHLSFQV--- 413
Cdd:PRK11073 210 VSL---ELPDNVRLIrdydpSLPELAHDPDQIEQVLLNIVRNALQALGP---EGGTITLR----------TRTAFQLtlh 273
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639325553 414 ---------ITIEDNGIGFSQDYADKIFVPFqrLHGRSqyKGTGIGLSVCRRIVERHGGTITAQSKDGEgATFIIKLPV 483
Cdd:PRK11073 274 geryrlaarIDIEDNGPGIPPHLQDTLFYPM--VSGRE--GGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
254-321 |
1.07e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 51.41 E-value: 1.07e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639325553 254 ELEEFAFVASHDLQEPLRKIQAFSDRLEtmfKDELGEKGMDYIGRMKNAAQRMSNLINDLLEFSRITT 321
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLL---DTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
254-319 |
1.47e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 51.06 E-value: 1.47e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 639325553 254 ELEEFAFVASHDLQEPLRKIQAFSDRLEtmfKDELGEKGMDYIGRMKNAAQRMSNLINDLLEFSRI 319
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLR---DEKLDEEQREYLETILRSAERLLRLINDLLDLSRI 63
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-481 |
2.72e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 52.63 E-value: 2.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 364 DKSQMQQLFLNLLSNAVKFRRPNISphIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHgrSQ 443
Cdd:cd16954 34 ERNDLMELLGNLLDNACKWCLEFVE--VTARQTDGGL------------HLIVDDDGPGVPESQRSKIFQRGQRLD--EQ 97
|
90 100 110
....*....|....*....|....*....|....*...
gi 639325553 444 YKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKL 481
Cdd:cd16954 98 RPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
245-481 |
2.89e-08 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 55.81 E-value: 2.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 245 SDELSRSNReleeFAFVASHDLQEPLR--KIQA----FSDRLETMFKDELG--EKGMDyigrmknaaqRMSNLINDLLEF 316
Cdd:PRK10337 231 HAMMVRERR----FTSDAAHELRSPLAalKVQTevaqLSDDDPQARKKALLqlHAGID----------RATRLVDQLLTL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 317 SRIttrgkDFDDtNLNEVVADILSDL------EIAIKESEAQIDV----EDLPVIQadksQMQQLFL-----NLLSNAVK 381
Cdd:PRK10337 297 SRL-----DSLD-NLQDVAEIPLEDLlqsavmDIYHTAQQAGIDVrltlNAHPVIR----TGQPLLLsllvrNLLDNAIR 366
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 382 FrrpniSPHikisyqdedifSSDHNTHLSFQVITIEDNGIGFSQDYADKIFVPFQRLHGRSQyKGTGIGLSVCRRIVERH 461
Cdd:PRK10337 367 Y-----SPQ-----------GSVVDVTLNARNFTVRDNGPGVTPEALARIGERFYRPPGQEA-TGSGLGLSIVRRIAKLH 429
|
250 260
....*....|....*....|
gi 639325553 462 GGTITAQSKDGEGatFIIKL 481
Cdd:PRK10337 430 GMNVSFGNAPEGG--FEAKV 447
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
375-482 |
1.16e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 49.98 E-value: 1.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 375 LLSNAVKFRrpnisphikiSYQDEDIFSSDHNTHlsFQVITIEDNGIGFSQDYADKIFVP-FQRLHGRSQYKGTGIGLSV 453
Cdd:cd16948 13 IVSNALKYS----------KQGGKIEIYSETNEQ--GVVLSIKDFGIGIPEEDLPRVFDKgFTGENGRNFQESTGMGLYL 80
|
90 100
....*....|....*....|....*....
gi 639325553 454 CRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16948 81 VKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
252-318 |
1.35e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 48.36 E-value: 1.35e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639325553 252 NRELEEFAFVASHDLQEPLRKIQAFSDRLETmfKDELGEKGMDYIGRMKNAAQRMSNLINDLLEFSR 318
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEE--ELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
309-483 |
1.35e-07 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 53.84 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 309 LINDLLEFSRIttrgkDFDDTNLNEVVADILSDL-----EIAIKESEAQIDVEDLP---VIQADKSQMQQLFLNLLSNAV 380
Cdd:PRK10604 258 LIEELLTYARL-----DRPQNELHLSEPDLPAWLsthlaDIQAVTPEKTVRLDTPHqgdYGALDMRLMERVLDNLLNNAL 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 381 KFRRPNIspHIKISYQDEdifssdhnthlsFQVITIEDNGIGFSQDYADKIFVPFQRL---HGRSQyKGTGIGLSVCRRI 457
Cdd:PRK10604 333 RYAHSRV--RVSLLLDGN------------QACLIVEDDGPGIPPEERERVFEPFVRLdpsRDRAT-GGCGLGLAIVHSI 397
|
170 180
....*....|....*....|....*.
gi 639325553 458 VERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:PRK10604 398 ALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
405-490 |
2.53e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 52.99 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 405 HNTHLSfqvITIEDNGIGFSQDYADKIFVpfqrlHGRSQyKGT--GIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:PRK11086 464 RNGWLH---CEVSDDGPGIAPDEIDAIFD-----KGYST-KGSnrGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
....*...
gi 639325553 483 VEAELFTL 490
Cdd:PRK11086 535 WDGERSNR 542
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-480 |
3.08e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 48.61 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 364 DKSQMQQLFLNLLSNAVKFRRP--NISPHIkisYQDEDIFSsdhnthlsfqvITIEDNGIGFSQDYADKIFVPFQRLH-G 440
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEggTVSISI---YDEEEYLY-----------FEIWDNGHGFSEQDLKKALELFYRDDtS 66
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 639325553 441 RSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIK 480
Cdd:cd16975 67 RRSGGHYGMGLYIAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
258-482 |
7.69e-07 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 51.12 E-value: 7.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 258 FAFVASHDLQEPLRKIqafsdRLETmfkdELGEK-----GMDYIGRMknaaQRMSNLINDLLEFSRIttrGKDFDDTN-- 330
Cdd:PRK10755 140 FTADVAHELRTPLAGI-----RLHL----ELLEKqhhidVAPLIARL----DQMMHTVEQLLQLARA---GQSFSSGHyq 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 331 ----LNEVVADILSDLEIAIKESEAQIDVEDLP---VIQADKSQMQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIfss 403
Cdd:PRK10755 204 tvklLEDVILPSQDELSEMLEQRQQTLLLPESAadiTVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGA--- 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 404 dhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRsqYKGTGIGLSVCRRIVERHGGTITAQS-KDGEGATFIIKLP 482
Cdd:PRK10755 281 ---------VLAVEDEGPGIDESKCGELSKAFVRMDSR--YGGIGLGLSIVSRITQLHHGQFFLQNrQERSGTRAWVWLP 349
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
192-486 |
9.65e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 50.00 E-value: 9.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 192 AITAITSGLLIIGMFIMTRLNLRNAAQYRFELEKQNETLAIKVSERTQEltlysDELSRSNRELeefafvasHDlqEPLR 271
Cdd:COG4585 3 ALALLGALALLVGALLGLLLALVLLRARRAERAAELERELAARAEEARE-----EERRRIAREL--------HD--GVGQ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 272 KIQAFSDRLETMFK--DELGEKGMDYIGRMKNAAQR----MSNLINDLlefsrittRGKDFDDTNLNEVVADILSDLEia 345
Cdd:COG4585 68 SLSAIKLQLEAARRllDADPEAAREELEEIRELAREalaeLRRLVRGL--------RPPALDDLGLAAALEELAERLL-- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 346 iKESEAQIDVE-DLPVIQADKSQMQQLFLNL---LSNAVKfrrpnispH-------IKISYQDEDIfssdhnthlsfqVI 414
Cdd:COG4585 138 -RAAGIRVELDvDGDPDRLPPEVELALYRIVqeaLTNALK--------HagatrvtVTLEVDDGEL------------TL 196
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 639325553 415 TIEDNGIGFSQDyadkifvpfqrlhgrsQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPVEAE 486
Cdd:COG4585 197 TVRDDGVGFDPE----------------AAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAAA 252
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
303-486 |
1.36e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 50.79 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 303 AQRMSNLINDLLEFSRITTRGKDfDDTNLNEVVADILSDLEIAIKESEAQIDVEdlpvIQADKSQMQQLFLNLLS----- 377
Cdd:COG2972 272 PEEAEEMLEALSKLLRYSLSKGD-ELVTLEEELELIKSYLEIQKLRFGDRLEVE----IEIDEELLDLLIPKLILqplve 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 378 NAVK--FRRPNISPHIKISYQDEDifssdhnthlSFQVITIEDNGIGFSQDYADKIFVPFQrlhgrSQYKGTGIGLS-VC 454
Cdd:COG2972 347 NAIEhgIEPKEGGGTIRISIRKEG----------DRLVITVEDNGVGMPEEKLEKLLEELS-----SKGEGRGIGLRnVR 411
|
170 180 190
....*....|....*....|....*....|....
gi 639325553 455 RRIVERHGG--TITAQSKDGEGATFIIKLPVEAE 486
Cdd:COG2972 412 ERLKLYYGEeyGLEIESEPGEGTTVTIRIPLEEE 445
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
309-485 |
1.91e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 50.29 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 309 LINDLLefsritTRGKDFDDTNLNEVVADILSDLEIAIKESEAQIDVEDLPV-IQADKSQMQQLFLN-LLSNAVKFRRP- 385
Cdd:COG3920 345 LVHELL------YQSEDWEGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVeLPADAAVPLGLILNeLVTNALKHAFLs 418
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 386 NISPHIKISYQDEDifssdhnTHLsfqVITIEDNGIGFSQDYADKifvpfqrlhgrsqyKGTGIGLSVCRRIVERHGGTI 465
Cdd:COG3920 419 GEGGRIRVSWRRED-------GRL---RLTVSDNGVGLPEDVDPP--------------ARKGLGLRLIRALVRQLGGTL 474
|
170 180
....*....|....*....|
gi 639325553 466 TAQSkdGEGATFIIKLPVEA 485
Cdd:COG3920 475 ELDR--PEGTRVRITFPLAE 492
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
422-482 |
6.76e-06 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 46.42 E-value: 6.76e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639325553 422 GFSQdyADKIfvpfqrlhgrSQYKGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLP 482
Cdd:cd16916 130 GFST--AEQV----------TDVSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-478 |
6.78e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 44.76 E-value: 6.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 368 MQQLFLNLLSNAVKFRRPNISPHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSqDYA-DKIFVPFQRL-HGRSQYK 445
Cdd:cd16945 5 LRQAINNLLDNAIDFSPEGGLIALQLEADTEGI------------ELLVFDEGSGIP-DYAlNRVFERFYSLpRPHSGQK 71
|
90 100 110
....*....|....*....|....*....|...
gi 639325553 446 GTGIGLSVCRRIVERHGGTITAQSKDGEGATFI 478
Cdd:cd16945 72 STGLGLAFVQEVAQLHGGRITLRNRPDGVLAFL 104
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
304-482 |
8.79e-06 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 48.23 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 304 QRMSNLINDLL-----EFSRITTRGKDFDdtnLNEVVADILSDLEIAIKESEAQIDVE-DLPVIQADKSQMQQLFLNLLS 377
Cdd:PRK09835 309 TRMAKMVSDMLflaqaDNNQLIPEKKMLD---LADEVGKVFDFFEAWAEERGVELRFVgDPCQVAGDPLMLRRAISNLLS 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 378 NAVKFRRPNISPHIKISYQDEDIfssdhnthlsfqVITIEDNGIGFSQDYADKIFVPFQRLHGRSQYKG--TGIGLSVCR 455
Cdd:PRK09835 386 NALRYTPAGEAITVRCQEVDHQV------------QLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGegSGIGLAIVK 453
|
170 180
....*....|....*....|....*..
gi 639325553 456 RIVERHGGTITAQSkDGEGATFIIKLP 482
Cdd:PRK09835 454 SIVVAHKGTVAVTS-DARGTRFVISLP 479
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
446-483 |
4.27e-05 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 45.94 E-value: 4.27e-05
10 20 30
....*....|....*....|....*....|....*...
gi 639325553 446 GTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKLPV 483
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
358-481 |
7.82e-04 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 39.75 E-value: 7.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 358 LP-VIQADKSQMQQLFLNLLSNAVKFRRP--NISPHIKISYQDEDIF----------SSDHNTHLSFqviTIEDNGIGFS 424
Cdd:cd16938 1 LPdVVVGDERRVFQVLLHMLGNLLKMRNGggNITFRVFLEGGSEDRSdrdwgpwrpsMSDESVEIRF---EVEINDSGSP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 639325553 425 qdyADKIFVPFQRLHGRSQY--KGTGIGLSVCRRIVERHGGTITAQSKDGEGATFIIKL 481
Cdd:cd16938 78 ---SIESASMRNSLNRRYNLseLGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
374-467 |
1.17e-03 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 41.54 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 374 NLLSNAVKFrrpnISPHIKISYQdedifSSDHNTHlsfqvITIEDNGIGFSQDYADKIFVPFQRLHG-RSqykGTGIGLS 452
Cdd:PRK10815 385 NVLDNACKY----CLEFVEISAR-----QTDEHLH-----IVVEDDGPGIPESKRELIFDRGQRADTlRP---GQGLGLS 447
|
90
....*....|....*
gi 639325553 453 VCRRIVERHGGTITA 467
Cdd:PRK10815 448 VAREITEQYEGKISA 462
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
52-257 |
1.94e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 40.82 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 52 LTTAIEKLHLSIVQAESGQRGYLL-TEEADylapyyDAIGQIEAQTDHVKSLHSEIDGQAERIAQLLVLVDSKIKELKQT 130
Cdd:TIGR02169 292 VKEKIGELEAEIASLERSIAEKEReLEDAE------ERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEE 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 131 VNLALD-----DKERRAMYVLNTHKGRKLYKQIREyVNEIQ---DRELLFKVSHFSKLAQIKNEAK-ITFAITAITSGLL 201
Cdd:TIGR02169 366 LEDLRAeleevDKEFAETRDELKDYREKLEKLKRE-INELKrelDRLQEELQRLSEELADLNAAIAgIEAKINELEEEKE 444
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 639325553 202 IIgmfimtRLNLRNAAQYRFELEKQNETLAIKVSERTQELTLYSDELSRSNRELEE 257
Cdd:TIGR02169 445 DK------ALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE 494
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
371-473 |
7.07e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 36.79 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639325553 371 LFLNLLSNAV----KFRRPNISPHIKISYQDedifssdhnthlSFQVITIEDNgigfsqdYADKIFVPFQRLHGRSQYKG 446
Cdd:cd16935 40 IFGNLLDNAIeacaKIDKENRFIHLKIRQKK------------GFLIISIENS-------YEGELKKKNGLFLSTKKDKN 100
|
90 100
....*....|....*....|....*..
gi 639325553 447 TGIGLSVCRRIVERHGGTITAQSKDGE 473
Cdd:cd16935 101 HGIGLKSIREIVKKYNGNLSIEYENGI 127
|
|
| |
