|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
70-439 |
3.66e-61 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 206.41 E-value: 3.66e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 70 SILTPELNNLNSDTYAMIYRD---------DVPiwHSESAVNVNFV--PQYIEPKAGAADFRRVVYNNTAYwQLSLTVIL 138
Cdd:PRK10815 69 SIELPENLDLNSPTLVLIYDEngkllwrqrDVP--WLEKMIQPEWLkkNGFHEIETDVNDSSLLLSGDHSA-QQQLKEVR 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 139 NNIDQSEQARFILLKRNDALLRL-------MDGFKQTL----VDWMFIMGIAIAGL-MAIGFI-----WSARPLQRLDKE 201
Cdd:PRK10815 146 EDDDDAEMTHSVAVNVYPATSRLpkltivvVDTIPQELqrsyMVWSWFSYVLLANLlLVIPLLwlaawWSLRPIEALAKQ 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 202 IKAIESGDIQEIKGLYPVELQTIKADLNLLLESQQRQKERYRASLSDLAHALKTPLAVLKSSPLA---------NDADA- 271
Cdd:PRK10815 226 VRELEEGEREQLDPNPPRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKTPLAVLQSTLRSlrsgkqmsvEQAEPi 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 272 -QEQLDRINVMIEHQLKRAA--TGASDTWKKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDKDYFLGDKTDLMELLGN 348
Cdd:PRK10815 306 mLEQISRISQQIGYYLHRASmrSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGN 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 349 LIDNACKACRSQVSIDVSQA-KTLSISICDDGPGIQPDKRESLLQRGTRLDTYESGHGVGMAIVSDLVKSYHGLLTISHS 427
Cdd:PRK10815 386 VLDNACKYCLEFVEISARQTdEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDS 465
|
410
....*....|..
gi 639351759 428 QrLGGAKFILEF 439
Cdd:PRK10815 466 P-LGGARMEVIF 476
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
305-439 |
6.22e-46 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 155.48 E-value: 6.22e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 305 PVIDSILSAMGKVYRDKDIIFNCKVSDKDYFLGDKTDLMELLGNLIDNACKACRSQVSIDVSQAKT-LSISICDDGPGIQ 383
Cdd:cd16954 1 PLLDSLCSALNKVYQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGgLHLIVDDDGPGVP 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 639351759 384 PDKRESLLQRGTRLDTYESGHGVGMAIVSDLVKSYHGLLTISHSqRLGGAKFILEF 439
Cdd:cd16954 81 ESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDS-PLGGARFEVVF 135
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
130-439 |
2.10e-34 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 130.80 E-value: 2.10e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 130 WQLSLTVILNNIDQSEQARFILLKRNDALLRLMDGFKQTLVDWMFIMGIAIAGLMAIGFIWSARPLQRLDKEIKAIESGD 209
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 210 IQEIKGLYPVELQTIKADLNLLLESQQRQKERYrasLSDLAHALKTPLAVLK--SSPLANDADA---------QEQLDRI 278
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRF---LANVSHELRTPLTAIRgyLELLLEELDEeqreyletiLRSADRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 279 NVMIEHQLK--RAATGASDTWKKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDK-DYFLGDKTDLMELLGNLIDNACK 355
Cdd:COG0642 158 LRLINDLLDlsRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDlPTVRGDPDRLRQVLLNLLSNAIK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 356 ACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLD--TYESGHGVGMAIVSDLVKSYHGLLTIShSQRL 430
Cdd:COG0642 238 YTPEGGTVTVSvrrEGDRVRISVEDTGPGIPPEDLERIFEPFFRTDpsRRGGGTGLGLAIVKRIVELHGGTIEVE-SEPG 316
|
....*....
gi 639351759 431 GGAKFILEF 439
Cdd:COG0642 317 KGTTFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
235-439 |
1.03e-30 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 118.47 E-value: 1.03e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 235 QQRQKERYRAS-LSDLAHALKTPLAV-------LKSSPLANDADAQEQLDRI-------NVMIEHQLK--RAATGASDTW 297
Cdd:COG2205 8 ELEELERLKSEfLANVSHELRTPLTSilgaaelLLDEEDLSPEERRELLEIIresaerlLRLIEDLLDlsRLESGKLSLE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 298 KKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDKD-YFLGDKTDLMELLGNLIDNACKACRSQVSIDVS---QAKTLSI 373
Cdd:COG2205 88 LEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPGGTITISarrEGDGVRI 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639351759 374 SICDDGPGIQPDKRESLLQRGTRLDTY--ESGHGVGMAIVSDLVKSYHGLLTIsHSQRLGGAKFILEF 439
Cdd:COG2205 168 SVSDNGPGIPEEELERIFERFYRGDNSrgEGGTGLGLAIVKRIVEAHGGTIWV-ESEPGGGTTFTVTL 234
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
119-439 |
2.35e-26 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 109.64 E-value: 2.35e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 119 FRRVVYNNTAYWQLSLTVILNNIDQSEQARFILLKRNDALLRLMDGFKQTLVDWMFIMGIAIAGLMAIGFIWSARPLQRL 198
Cdd:COG5002 37 LLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 199 DKEIKAIESGDIQEIKGLYPVELQTIKADLNLLLE----SQQRQKERYRASL-SDLAHALKTPLAVLKS------SPLAN 267
Cdd:COG5002 117 LLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVerdiTELERLEQMRREFvANVSHELRTPLTSIRGylelllDGAAD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 268 DAD--------AQEQLDRINVMIE--HQLKRAATGASDTWKKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDKDYFL- 336
Cdd:COG5002 197 DPEerreyleiILEEAERLSRLVNdlLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVl 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 337 GDKTDLMELLGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYES----GHGVGMA 409
Cdd:COG5002 277 GDPDRLEQVLTNLLDNAIKYTPEGGTITVSlreEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSretgGTGLGLA 356
|
330 340 350
....*....|....*....|....*....|
gi 639351759 410 IVSDLVKSYHGLLTIsHSQRLGGAKFILEF 439
Cdd:COG5002 357 IVKHIVEAHGGRIWV-ESEPGKGTTFTITL 385
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
337-439 |
6.08e-21 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 87.70 E-value: 6.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 337 GDKTDLMELLGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYE---SGHGVGMAI 410
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTlerDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiGGTGLGLSI 80
|
90 100
....*....|....*....|....*....
gi 639351759 411 VSDLVKSYHGLLTIShSQRLGGAKFILEF 439
Cdd:smart00387 81 VKKLVELHGGEISVE-SEPGGGTTFTITL 108
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
337-439 |
3.46e-20 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 85.50 E-value: 3.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 337 GDKTDLMELLGNLIDNACKAC--RSQVSIDVSQAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYE-SGHGVGMAIVSD 413
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAakAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGgGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*.
gi 639351759 414 LVKSYHGLLTIShSQRLGGAKFILEF 439
Cdd:pfam02518 81 LVELLGGTITVE-SEPGGGTTVTLTL 105
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
305-444 |
6.34e-18 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 85.29 E-value: 6.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 305 PVIDSILSAMGKVYRDKDIIFNCKVSD--KDYFLGDkTDLMELLGNLIDNACKACRSQ------VSIDVSQAK-TLSISI 375
Cdd:COG3290 244 PVLAALLLGKAARARERGIDLTIDIDSdlPDLPLSD-TDLVTILGNLLDNAIEAVEKLpeeerrVELSIRDDGdELVIEV 322
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639351759 376 CDDGPGIQPDKRESLLQRG--TRLdtyESGHGVGMAIVSDLVKSYHGLLTIsHSQRLGGAKFILEFNYHEK 444
Cdd:COG3290 323 EDSGPGIPEELLEKIFERGfsTKL---GEGRGLGLALVKQIVEKYGGTIEV-ESEEGEGTVFTVRLPKEGE 389
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
117-439 |
1.81e-17 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 83.31 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 117 ADFRRVVYNNTAYWQLSLTVILNNIDQSEQARFILLKRNDALLRLMDGFKQTLVDWMFIMGIAIAGLMAIGFIWSARPLQ 196
Cdd:COG4191 8 LLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 197 RLDKEIKAIESGDIQEIKGLYPVELQTIKADLNLLLESQQRQKERYR-----ASL----SDLAHALKTPLAVLKSS---- 263
Cdd:COG4191 88 LLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVqseklAALgelaAGIAHEINNPLAAILGNaell 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 264 -----PLANDADAQEQLDRINVMIEH------QLKRAATGASDTwKKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDK 332
Cdd:COG4191 168 rrrleDEPDPEELREALERILEGAERaaeivrSLRAFSRRDEEE-REPVDLNELIDEALELLRPRLKARGIEVELDLPPD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 333 D-YFLGDKTDLMELLGNLIDNACKACRS----QVSIDVSQA-KTLSISICDDGPGIQPDKRESL---------LQRGTrl 397
Cdd:COG4191 247 LpPVLGDPGQLEQVLLNLLINAIDAMEEgeggRITISTRREgDYVVISVRDNGPGIPPEVLERIfepffttkpVGKGT-- 324
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 639351759 398 dtyesghGVGMAIVSDLVKSYHGLLTIsHSQRLGGAKFILEF 439
Cdd:COG4191 325 -------GLGLSISYGIVEKHGGRIEV-ESEPGGGTTFTITL 358
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
342-439 |
1.93e-17 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 77.26 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYES--GHGVGMAIVSDLVK 416
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISlrqEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREggGTGLGLAIVRRIVE 80
|
90 100
....*....|....*....|...
gi 639351759 417 SYHGLLTIsHSQRLGGAKFILEF 439
Cdd:cd00075 81 AHGGRITV-ESEPGGGTTFTVTL 102
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
337-431 |
7.67e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 75.91 E-value: 7.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 337 GDKTDLMELLGNLIDNACKACR--SQVSIDVSQAKTLSISICDDGPGIQPDKRESLLQRGTRLD-TYESGHGVGMAIVSD 413
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPqgSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDgQNYGGSGLGLSIVKR 88
|
90
....*....|....*...
gi 639351759 414 LVKSYHGLLTISHSQRLG 431
Cdd:cd16940 89 IVELHGGQIFLGNAQGGG 106
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
234-444 |
1.70e-16 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 81.16 E-value: 1.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 234 SQQRQKERyRASLSD----LAHALKTPLAVLKSS----------PLANDAD--------AQEQLDRINVMIEHQLKRAAT 291
Cdd:COG5000 190 TELLRAER-LAAWGElarrIAHEIKNPLTPIQLSaerlrrkladKLEEDREdleraldtIIRQVDRLKRIVDEFLDFARL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 292 GASDtwKKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDKD-YFLGDKTDLMELLGNLIDNACKACRSQVSIDVS---Q 367
Cdd:COG5000 269 PEPQ--LEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVStrrE 346
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639351759 368 AKTLSISICDDGPGIQPDKRESLLQRG--TRldtyESGHGVGMAIVSDLVKSYHGLLTIsHSQRLGGAKFILEFNYHEK 444
Cdd:COG5000 347 DGRVRIEVSDNGPGIPEEVLERIFEPFftTK----PKGTGLGLAIVKKIVEEHGGTIEL-ESRPGGGTTFTIRLPLAEE 420
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
6-439 |
1.96e-16 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 81.28 E-value: 1.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 6 ISLKIRQG--FILVFVLLVALP--ILFYSIGKAYYASLVDATEKNLEAHLYSLISEVDFTERGIIMPSSIltPELNNLNS 81
Cdd:TIGR01386 2 RSLTLRLAllFAAVTALVFALSgfMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEDIKRLQEKI--DDLLVGHS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 82 DTYAMIYRDDVPIWHSESAVNVnfVPQYIEPKAGAADFRRVVYNNTAYWQLSLTV-ILNNIDQSEQARFILLKRNDALLR 160
Cdd:TIGR01386 80 DLALSILNPDGRLLFERAQGAA--LVPAVAANDALLELDQADAKMTHYRSILRSVaALPGGKGRKPVQITVALDINAHTH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 161 LMDGFKQTLVdwmfimGIAIAGLMAIGFI--WSAR----PLQRLDKEIKAIESGDI-QEIK-GLYPVELQTIKADLNLLL 232
Cdd:TIGR01386 158 LLDALRKWLI------LIAVLLVLLTALLgwWITRlglePLRRLSAVAARISPESLdQRLDpSRAPAELRELAQSFNAML 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 233 esqQRQKERYR--ASLS-DLAHALKTPLA-------VLKSSPLANDA------DAQEQLDRINVMIEHQ--LKRAATGAS 294
Cdd:TIGR01386 232 ---GRLEDAFQrlSQFSaDLAHELRTPLTnllgqtqVALSQPRTGEEyrevleSNLEELERLSRMVSDMlfLARADNGQL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 295 DTWKKQTPIKPVIDSILSAMGKVYRDKDIIFncKVSDKDYFLGDKTDLMELLGNLIDNACKACRSQVSIDVS---QAKTL 371
Cdd:TIGR01386 309 ALERVRLDLAAELAKVAEYFEPLAEERGVRI--RVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRierRSDEV 386
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 639351759 372 SISICDDGPGIQPDKRESLLQRGTRLDT----YESGHGVGMAIVSDLVKSYHGllTISHSQRLGGAKFILEF 439
Cdd:TIGR01386 387 RVSVSNPGPGIPPEHLSRLFDRFYRVDParsnSGEGTGLGLAIVRSIMEAHGG--RASAESPDGKTRFILRF 456
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
169-437 |
3.65e-16 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 80.03 E-value: 3.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 169 LVDWMFIMGIAIAglMAIG-FIWsARP----LQRLDKEIKAIESGDIQEIKGLYP--------VELQTIKADLNLLLESq 235
Cdd:PRK10604 136 LLDIALLALIGLS--LAFPvFLW-MRPhwqdMLKLEAAAQRLGDGHLAERIHFDEgsslerlgVAFNQMADNINALIAS- 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 236 qrqkeryRASLSD-LAHALKTPLAVLKSS-PLANDADAQEQ------LDRINVMIEHQLKRAATGASDTWKKQTPI--KP 305
Cdd:PRK10604 212 -------KKQLIDgIAHELRTPLVRLRYRlEMSDNLSAAESqalnrdIGQLEALIEELLTYARLDRPQNELHLSEPdlPA 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 306 VIDSILSAMGKVYRDKDIifNCKVSDKDYFLGDKTDLME-LLGNLIDNACKACRSQVSIDVS-QAKTLSISICDDGPGIQ 383
Cdd:PRK10604 285 WLSTHLADIQAVTPEKTV--RLDTPHQGDYGALDMRLMErVLDNLLNNALRYAHSRVRVSLLlDGNQACLIVEDDGPGIP 362
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 384 PDKRESLLQRGTRLDtyES------GHGVGMAIVSDLVKSYHGLLTISHSQrLGGAKFIL 437
Cdd:PRK10604 363 PEERERVFEPFVRLD--PSrdratgGCGLGLAIVHSIALAMGGSVNCDESE-LGGARFSF 419
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
116-439 |
2.00e-14 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 75.21 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 116 AADFRRVVYNNTAYWQLSLTVILNNIDQSEQARFILLKRNDALLRLMDGFKQTLVDWMFIMGIAIAGLMAIGFIWSARPL 195
Cdd:COG4251 145 LALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGG 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 196 QRLDKEIKAIESGDIQEIKGLYPVELQTIKADLNLLLESQQRQKERYRASL----SDL-------AHALKTPL------- 257
Cdd:COG4251 225 LGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELersnEELeqfayvaSHDLREPLrkisgfs 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 258 -AVLKSSPLANDADAQEQLDRI-------NVMIEH--QLKRAATGASDtwKKQTPIKPVIDSILSAMGKVYRDKDIIFNc 327
Cdd:COG4251 305 qLLEEDYGDKLDEEGREYLERIrdaaermQALIDDllAYSRVGRQELE--FEPVDLNELLEEVLEDLEPRIEERGAEIE- 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 328 kVSDKDYFLGDKTDLMELLGNLIDNACKACRS----QVSIDVSQAKT-LSISICDDGPGIQPDKRE---SLLQRGTRLDT 399
Cdd:COG4251 382 -VGPLPTVRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGeWVFSVRDNGIGIDPEYAEkifEIFQRLHSRDE 460
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 639351759 400 YEsGHGVGMAIVSDLVKSYHGLLTIsHSQRLGGAKFILEF 439
Cdd:COG4251 461 YE-GTGIGLAIVKKIVERHGGRIWV-ESEPGEGATFYFTL 498
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
190-432 |
5.99e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 72.69 E-value: 5.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 190 WSARPLQRLDKEIKA---------IESGDIQEIkglypvelQTIKADLNLLLESQQRQKERYRASLSDLAHALKTPLAVL 260
Cdd:PRK10755 84 WITRPLAELQKELEArtadnltpiAIHSSTLEI--------EAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 261 --------KSSPlandADAQEQLDRINVM---IEHQLKRAATGASDTWKKQTPIKPVIDSI------LSAMGKVyRDKDI 323
Cdd:PRK10755 156 rlhlelleKQHH----IDVAPLIARLDQMmhtVEQLLQLARAGQSFSSGHYQTVKLLEDVIlpsqdeLSEMLEQ-RQQTL 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 324 IFNCKVSDKdYFLGDKTDLMELLGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTY 400
Cdd:PRK10755 231 LLPESAADI-TVQGDATLLRLLLRNLVENAHRYSPEGSTITIKlsqEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSR 309
|
250 260 270
....*....|....*....|....*....|..
gi 639351759 401 ESGHGVGMAIVSDLVKSYHGLLTISHSQRLGG 432
Cdd:PRK10755 310 YGGIGLGLSIVSRITQLHHGQFFLQNRQERSG 341
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-437 |
2.54e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 65.91 E-value: 2.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 346 LGNLIDNACKACRSQVSIDVS-QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYES----GHGVGMAIVSDLVKSYHG 420
Cdd:cd16939 5 LDNLLRNALRYAHRTVRIALLvSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDratgGFGLGLAIVHRVALWHGG 84
|
90
....*....|....*..
gi 639351759 421 LLTISHSQrLGGAKFIL 437
Cdd:cd16939 85 HVECDDSE-LGGACFRL 100
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
190-432 |
4.89e-13 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 70.73 E-value: 4.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 190 WS-ARPLQRLDKEIKAIESGDIQEIKGLY--PVEL--------QTIKAdLNLLLESQQRQkeryrasLSDLAHALKTPLA 258
Cdd:PRK09470 188 WSlAKPARKLKNAADEVAQGNLRQHPELEtgPQEFrqagasfnQMVTA-LERMMTSQQRL-------LSDISHELRTPLT 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 259 VLKsspLAN----------------DADAQeqldRINVMI-----------EHQLKRAATGASDTWkkqtpikpviDSIL 311
Cdd:PRK09470 260 RLQ---LATallrrrqgeskeleriETEAQ----RLDSMIndllvlsrnqqKNHLERETFKANSLW----------SEVL 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 312 samgkvyrdKDIIFNCKVSDKD---------YFL-GDKTDLMELLGNLIDNACKACRSQVSIDVS-QAKTLSISICDDGP 380
Cdd:PRK09470 323 ---------EDAKFEAEQMGKSltvsappgpWPInGNPNALASALENIVRNALRYSHTKIEVAFSvDKDGLTITVDDDGP 393
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 639351759 381 GIQPDKRESLLQRGTRLDT---YES-GHGVGMAIVSDLVKSYHGLLTISHSQrLGG 432
Cdd:PRK09470 394 GVPEEEREQIFRPFYRVDEardRESgGTGLGLAIVENAIQQHRGWVKAEDSP-LGG 448
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-431 |
4.32e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 62.08 E-value: 4.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACKACRSQVSIDV-SQAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYE--SGHGVGMAIVSDLVKSY 418
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSdGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARgtSGTGLGLAIVQRISDAH 80
|
90
....*....|...
gi 639351759 419 HGLLTISHSQRLG 431
Cdd:cd16950 81 GGSLTLANRAGGG 93
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
232-439 |
5.42e-12 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 66.79 E-value: 5.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 232 LESQQRQKERYRAS---LSDLAHALKTPLAVLKSSP--LANDADAQEQLDRINVMIEhQLKRAAT---------GASDTW 297
Cdd:COG3852 122 LERELRRAEKLAAVgelAAGLAHEIRNPLTGIRGAAqlLERELPDDELREYTQLIIE-EADRLNNlvdrllsfsRPRPPE 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 298 KKQTPIKPVIDSILSAMGKVY-RDKDIIFNCKVSDKDyFLGDKTDLMELLGNLIDNACKAC------------RSQVSID 364
Cdd:COG3852 201 REPVNLHEVLERVLELLRAEApKNIRIVRDYDPSLPE-VLGDPDQLIQVLLNLVRNAAEAMpeggtitirtrvERQVTLG 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 365 VSQAKT-LSISICDDGPGIQPDKRESLlqrgtrLD----TYESGHGVGMAIVSDLVKSYHGLLTIsHSQRLGGAKFILEF 439
Cdd:COG3852 280 GLRPRLyVRIEVIDNGPGIPEEILDRI------FEpfftTKEKGTGLGLAIVQKIVEQHGGTIEV-ESEPGKGTTFRIYL 352
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
175-440 |
1.31e-11 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 66.63 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 175 IMGIAIAGLMAIGFI-W-------SARpLQRLDKEIKAIESGDIQE---IKG------------LYPVELQTIKADLNLL 231
Cdd:COG4192 328 LLAIALLSLLLAVLInYfyvrrrlVKR-LNALSDAMAAIAAGDLDVpipVDGndeigriarllrVFRDQAIEKTQELETE 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 232 LESQQRQKERYRASLSDLAHALK--------TPLAVLKSSPL----------------ANDADAQEQLDRINVMIEHQLK 287
Cdd:COG4192 407 IEERKRIEKNLRQTQDELIQAAKmavvgqtmTSLAHELNQPLnamsmylfsakkaleqENYAQLPTSLDKIEGLIERMDK 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 288 RAATGASDTWKKQTPIKPV--IDSILSAMGKV---YRDKDIIFNckVSDKDYFLGDKTDLMELLGNLIDNACKACRSQVS 362
Cdd:COG4192 487 IIKSLRQFSRKSDTPLQPVdlRQVIEQAWELVesrAKPQQITLH--IPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQ 564
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 363 IDV---SQAKTLSISICDDGPGIqpDKRESLLQRGTrlDTYESGHGVGMAIVSDLVKSYHGLLTIShSQRLGGAKFILEF 439
Cdd:COG4192 565 ISVdllSNAENLRVAISDNGNGW--PLVDKLFTPFT--TTKEVGLGLGLSICRSIMQQFGGDLYLA-STLERGAMVILEF 639
|
.
gi 639351759 440 N 440
Cdd:COG4192 640 N 640
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
338-439 |
2.28e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 57.47 E-value: 2.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 338 DKTDLMELLGNLIDNACKACRSQVSIDVSQAKT---LSISICDDGPGIQPDKRESLLQRGTRLDTYES----GHGVGMAI 410
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTpqeVRLDVEDSAPGVSDDQLARLFERFYRVESSRNrasgGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 639351759 411 VSDLVKSYHGLLTISHSQrLGGAKFILEF 439
Cdd:cd16946 81 CHNIALAHGGTISAEHSP-LGGLRLVLTL 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-437 |
2.82e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.30 E-value: 2.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACKAC------RSQVSIDVSQ-AKTLSISICDDGPGIQPDKRESLLQRG--TRldtYESGHGVGMAIVS 412
Cdd:cd16915 1 LITIVGNLIDNALDALaatgapNKQVEVFLRDeGDDLVIEVRDTGPGIAPELRDKVFERGvsTK---GQGERGIGLALVR 77
|
90 100
....*....|....*....|....*
gi 639351759 413 DLVKSYHGLLTIShSQRLGGAKFIL 437
Cdd:cd16915 78 QSVERLGGSITVE-SEPGGGTTFSI 101
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-431 |
1.34e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 55.02 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 348 NLIDNACKACRSQVSIDVSQAKT-LSISICDDGPGIQPDKRESLLQRGTRLDTYES----GHGVGMAIVSDLVKSYHGLL 422
Cdd:cd16949 7 NVLRNALRYSPSKILLDISQDGDqWTITITDDGPGVPEDQLEQIFLPFYRVDSARDresgGTGLGLAIAERAIEQHGGKI 86
|
....*....
gi 639351759 423 TISHSQRLG 431
Cdd:cd16949 87 KASNRKPGG 95
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
306-426 |
1.79e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 55.66 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 306 VIDSILSAMGKVYRDKDIIFNCKVSDKDYFLGDKTDLMELLGNLIDNACKACR------SQVSIDVSQAK-TLSISICDD 378
Cdd:cd16935 1 ALDSLLSEKLELAREKGIEFTIEIDIPILLPISPLDLCIIFGNLLDNAIEACAkidkenRFIHLKIRQKKgFLIISIENS 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 639351759 379 GPGIQPDKRESLLQrgtrlDTYESGHGVGMAIVSDLVKSYHGLLTISH 426
Cdd:cd16935 81 YEGELKKKNGLFLS-----TKKDKNHGIGLKSIREIVKKYNGNLSIEY 123
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
338-433 |
1.21e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 52.54 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 338 DKTDLMELLGNLIDNACKAC------RSQVSIDVS--QAKTLSISICDDGPGIQPDKRESLLQrgTRLDTYESGHGVGMA 409
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIegrpsdVGEVRIRVEadQDGRIVLIVCDNGKGFPREMRHRATE--PYVTTRPKGTGLGLA 78
|
90 100
....*....|....*....|....
gi 639351759 410 IVSDLVKSYHGLLTIShSQRLGGA 433
Cdd:cd16944 79 IVKKIMEEHGGRISLS-NREAGGA 101
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
234-435 |
3.16e-08 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 55.40 E-value: 3.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 234 SQQRQKERYRASL-SDLAHALKTPLAVLK-----------SSPLANDA--DAQEQLDRINVMIEHQL---KRAATGASDt 296
Cdd:PRK11006 195 TQMHQLEGARRNFfANVSHELRTPLTVLQgylemmqdqplEGALREKAlhTMREQTQRMEGLVKQLLtlsKIEAAPTID- 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 297 wkkqtpIKPVIDsiLSAMGKVYRDK---------DIIFNckVSDKDYFLGDKTDLMELLGNLIDNACKACRSQVSIDVSQ 367
Cdd:PRK11006 274 ------LNEKVD--VPMMLRVLEREaqtlsqgkhTITFE--VDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRW 343
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639351759 368 AKTLS---ISICDDGPGIQPDKRESLLQRGTRLDTYES----GHGVGMAIVSDLVKSYHGLLTIShSQRLGGAKF 435
Cdd:PRK11006 344 QRVPQgaeFSVEDNGPGIAPEHIPRLTERFYRVDKARSrqtgGSGLGLAIVKHALSHHDSRLEIE-SEVGKGTRF 417
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-435 |
3.57e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 51.24 E-value: 3.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACKAC------RSQVSIDVSQA--KTLSISICDDGPGIQPDKRESLLQRGTrlDTYESGHGVGMAIVSD 413
Cdd:cd16920 1 IQQVLINLVRNGIEAMseggceRRELTIRTSPAddRAVTISVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICRS 78
|
90 100
....*....|....*....|...
gi 639351759 414 LVKSYHGllTISHSQR-LGGAKF 435
Cdd:cd16920 79 IIEAHGG--RLSVESPaGGGATF 99
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
346-432 |
3.97e-08 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 55.30 E-value: 3.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 346 LGNLIDNACKACRSQVSIDVSQ-AKTLSISICDDGPGIQPDKRESLLQRGTRLDTYE--SGHGVGMAIVSDLVKSYHGLL 422
Cdd:PRK09467 336 LANLVVNAARYGNGWIKVSSGTeGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARgsSGTGLGLAIVKRIVDQHNGKV 415
|
90
....*....|
gi 639351759 423 TISHSQRlGG 432
Cdd:PRK09467 416 ELGNSEE-GG 424
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
348-438 |
4.00e-08 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 51.34 E-value: 4.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 348 NLIDNACKAC----RSQVSIDVSQAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYES----GHGVGMAIVSDLVKSYH 419
Cdd:cd16925 11 NLLSNAFKFTpdggRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTrahgGTGLGLSIVKEFVELHG 90
|
90
....*....|....*....
gi 639351759 420 GLLTISHSQRlGGAKFILE 438
Cdd:cd16925 91 GTVTVSDAPG-GGALFQVE 108
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
154-432 |
5.87e-08 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 54.66 E-value: 5.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 154 RNDALLRLMDGfkqTLVDWMFIMGIAIagLMAIGFIW-SARPLQRLDKEI--KAIESGDIQEIKGLyPVELQTIKADLNL 230
Cdd:PRK10337 152 REDMALAIVAG---QLIPWLVALPIML--IILMVLLGrELAPLKKLALALrmRDPDSETPLNATGV-PSEVRPLVEALNQ 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 231 LLESQQRQKERYRASLSDLAHALKTPLAVLK----SSPLANDaDAQEQ----------LDRINVMIEH--QLKRAATGAS 294
Cdd:PRK10337 226 LFARTHAMMVRERRFTSDAAHELRSPLAALKvqteVAQLSDD-DPQARkkallqlhagIDRATRLVDQllTLSRLDSLDN 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 295 DTWKKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDKDYFLGDKTDLMELL-GNLIDNACKACRSQVSIDVsqakTLS- 372
Cdd:PRK10337 305 LQDVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLvRNLLDNAIRYSPQGSVVDV----TLNa 380
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639351759 373 --ISICDDGPGIQPDKRESLLQRGTRLDTYE-SGHGVGMAIVSDlVKSYHGlLTISHSQRLGG 432
Cdd:PRK10337 381 rnFTVRDNGPGVTPEALARIGERFYRPPGQEaTGSGLGLSIVRR-IAKLHG-MNVSFGNAPEG 441
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
232-420 |
9.77e-08 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 53.80 E-value: 9.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 232 LESQQRQKERYrasLSDLAHALKTPL--AVLKSSPLA---NDAD--------------AQEQLDRINVMIeHQLKRAATG 292
Cdd:PRK09303 144 LLEQLKFKDRV---LAMLAHDLRTPLtaASLALETLElgqIDEDtelkpalieqlqdqARRQLEEIERLI-TDLLEVGRT 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 293 ASDTWK---KQTPIKPVIDSILSAMGKVYRDKDIIFNCKV-SDKDYFLGDKTDLMELLGNLIDNACKACRSQVSIDVS-- 366
Cdd:PRK09303 220 RWEALRfnpQKLDLGSLCQEVILELEKRWLAKSLEIQTDIpSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSml 299
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 639351759 367 --QAKTLSISICDDGPGIQPDKRESLLQRGTRL--DTYESGHGVGMAIVSDLVKSYHG 420
Cdd:PRK09303 300 hrTTQKVQVSICDTGPGIPEEEQERIFEDRVRLprDEGTEGYGIGLSVCRRIVRVHYG 357
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
300-424 |
1.01e-07 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 54.15 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 300 QTPIKPVIDSILSA------MGKVYRDKDIIFNCKVSDKDYF--LGDK---TDLMELLGNLIDNACKACRSQV--SIDVS 366
Cdd:PRK11086 381 QEEIGSLLGKIKSPviagflLGKISRARELGITLIISEDSQLpdSGDEdqvHELITILGNLIENALEAVGGEEggEISVS 460
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639351759 367 ---QAKTLSISICDDGPGIQPDKRESLLQRGtrLDTYESGHGVGMAIVSDLVKSYHGLLTI 424
Cdd:PRK11086 461 lhyRNGWLHCEVSDDGPGIAPDEIDAIFDKG--YSTKGSNRGVGLYLVKQSVENLGGSIAV 519
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
232-438 |
2.66e-07 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 53.11 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 232 LESQQRQKERY--RAS--LSDLAHALKTPL-------AVLKSSPLAND----ADAQEQ-----LDRINVMIEhqLKRAAT 291
Cdd:PRK15347 384 LAEAKQRAEQAnkRKSehLTTISHEIRTPLngvlgalELLQNTPLTAEqmdlADTARQctlslLAIINNLLD--FSRIES 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 292 GASDTWKKQTPIKPVID-SILSAMGKVYrDKDIIFNCKVSDK--DYFLGDKTDLMELLGNLIDNACKACRS-QVSIDV-S 366
Cdd:PRK15347 462 GQMTLSLEETALLPLLDqAMLTIQGPAQ-SKSLTLRTFVGAHvpLYLHLDSLRLRQILVNLLGNAVKFTETgGIRLRVkR 540
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639351759 367 QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYESGHGVGMAIVSDLVKSYHGLLTIshSQRLG-GAKFILE 438
Cdd:PRK15347 541 HEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTL--FSTPGvGSCFSLV 611
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
273-431 |
2.87e-07 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 52.81 E-value: 2.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 273 EQLDRINVMIEHQLKRAATGASDtwKKQTPIKPVIDSILSAMGKVYRDKDIIFNCKVSDKDYFL-GDKTDLMELLGNLID 351
Cdd:COG5805 328 SELDRIESIISEFLALAKPQAVN--KEKENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIyCDENQIKQVFINLIK 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 352 NACKACRSQVSIDVSQAK---TLSISICDDGPGIQPDkresLLQR-GTR-LDTYESGHGVGMAIVSDLVKSYHGLLTISH 426
Cdd:COG5805 406 NAIEAMPNGGTITIHTEEednSVIIRVIDEGIGIPEE----RLKKlGEPfFTTKEKGTGLGLMVSYKIIENHNGTIDIDS 481
|
....*
gi 639351759 427 SQRLG 431
Cdd:COG5805 482 KVGKG 486
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-436 |
8.14e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 47.32 E-value: 8.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACKACRSQVS--IDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYESGH--GVGMAIVSDL 414
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGaedVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEgtGVGLAIVRKI 80
|
90 100
....*....|....*....|..
gi 639351759 415 VKSYHGLLTIShSQRLGGAKFI 436
Cdd:cd16921 81 IERHGGRIWLE-SEPGEGTTFY 101
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
9-444 |
1.02e-06 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 50.79 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 9 KIRQGFILVFVLLVALPILFYSIGKAYYASLVDATEKNLEAHLYSLISEVDFTERGIIMPSSILTPELNNLNSDTYAMIY 88
Cdd:COG2972 1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 89 RDDVPIWHSESAVNVNFVPQYIEPKAGAADFRRVVYNNTAYWQLSLTVILNNIDQseQARFILLKRNDALLRLMDGFKQT 168
Cdd:COG2972 81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLL--GWTLVSLIPKSELFRGLFSLRRL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 169 LVdWMFIMGIAIAGLMAIGFIWS-ARPLQRLDKEIKAIESGDIQEIKGLYPVELQTIKADLNLLLESQQRQKERYRASLS 247
Cdd:COG2972 159 IL-LIILLLLLLALLLSYLLSRSiTRPIKRLKKAMKKVEKGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEVYELEL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 248 DLAHA-LKT------P------LAVLKSspLANDADAQEqldrINVMIEH--QLKRAATGASDTWkkqTPIK---PVIDS 309
Cdd:COG2972 238 EKKEAeLKAlqaqinPhflfntLNSIRW--LAELEDPEE----AEEMLEAlsKLLRYSLSKGDEL---VTLEeelELIKS 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 310 ILSAMGKVYRDKdIIFNCKVSDkdyflgdktDLME------LLGNLIDNACKA----CRSQVSIDVS---QAKTLSISIC 376
Cdd:COG2972 309 YLEIQKLRFGDR-LEVEIEIDE---------ELLDllipklILQPLVENAIEHgiepKEGGGTIRISirkEGDRLVITVE 378
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639351759 377 DDGPGIQPDKRESLLQrgtRLDTYESGHGVGMAIVSDLVKSYHG---LLTIShSQRLGGAKFILEFNYHEK 444
Cdd:COG2972 379 DNGVGMPEEKLEKLLE---ELSSKGEGRGIGLRNVRERLKLYYGeeyGLEIE-SEPGEGTTVTIRIPLEEE 445
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
246-431 |
2.78e-06 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 49.73 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 246 LSDLAHALKTP-------LAVLKSSPLAND----------ADAQEQLDRINVMIEhqLKRAATGASDTWKKQTPIKPVID 308
Cdd:PRK09959 716 LATMSHEIRTPissimgfLELLSGSGLSKEqrveaislayATGQSLLGLIGEILD--VDKIESGNYQLQPQWVDIPTLVQ 793
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 309 SILSAMGKVYRDKDIIFNCKVSDKDYFLG--DKTDLMELLGNLIDNA--------CKACRSQVSIDVSQAkTLSISICDD 378
Cdd:PRK09959 794 NTCHSFGAIAASKSIALSCSSTFPDHYLVkiDPQAFKQVLSNLLSNAlkfttegaVKITTSLGHIDDNHA-VIKMTIMDS 872
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 639351759 379 GPGIQPDKRESLLQR--GTRLDTYESGHGVGMAIVSDLVKSYHGLLTISHSQRLG 431
Cdd:PRK09959 873 GSGLSQEEQQQLFKRysQTSAGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIG 927
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
338-439 |
3.64e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 45.53 E-value: 3.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 338 DKTDLMELLGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGI-QPDKRESLLQ--RGTRLDTYESGHGVGMAIV 411
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISiydEEEYLYFEIWDNGHGFsEQDLKKALELfyRDDTSRRSGGHYGMGLYIA 80
|
90 100
....*....|....*....|....*...
gi 639351759 412 SDLVKSYHGLLTISHSQRlGGAKFILEF 439
Cdd:cd16975 81 KNLVEKHGGSLIIENSQK-GGAEVTVKI 107
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
342-435 |
3.65e-06 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 49.26 E-value: 3.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LME-LLGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTyES---GHGVGMAIVSDL 414
Cdd:PRK10490 778 LFErVLINLLENAVKYAGAQAEIGIDahvEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNK-ESaipGVGLGLAICRAI 856
|
90 100
....*....|....*....|.
gi 639351759 415 VKSYHGLLTISHSQRlGGAKF 435
Cdd:PRK10490 857 VEVHGGTIWAENRPE-GGACF 876
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
172-433 |
5.37e-06 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 48.69 E-value: 5.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 172 WMFIMGIAIAGLMAIgfiWSARPLQRLDKEIKAIESGDIQEIKGLYPVELqtikADLNLLLESQQRQ---K---ERYRAS 245
Cdd:PRK11100 190 LLLGIALLIGAGVVW---WLNRSIRRLTRYADAVTEGKPVPLPKLGSSEL----RELAQALESMRVKlegKayvEQYVQT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 246 LsdlAHALKTPLA-------VLKSSPLAND-----ADAQEQLDRINVMIEHQLKRAATGASDTWKKQTPI--KPVIDSIL 311
Cdd:PRK11100 263 L---THELKSPLAairgaaeLLQEDPPPEDrarftGNILTQSARLQQLIDRLLELARLEQRQELEVLEPValAALLEELV 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 312 SAMGKVYRDKDIIFNCKVSDkDYFLGDkTDLMEL-LGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGIqPD-K 386
Cdd:PRK11100 340 EAREAQAAAKGITLRLRPDD-ARVLGD-PFLLRQaLGNLLDNAIDFSPEGGTITLSaevDGEQVALSVEDQGPGI-PDyA 416
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 639351759 387 RESLLQRG---TRLDTYESGHGVGMAIVSDLVKSYHGLLTIsHSQRLGGA 433
Cdd:PRK11100 417 LPRIFERFyslPRPANGRKSTGLGLAFVREVARLHGGEVTL-RNRPEGGV 465
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
250-439 |
1.51e-05 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 47.28 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 250 AHALKTPLAVLKS-----SPLANDADAQ------EQLDRINVMIEHQLKRAATGASDTwkKQTPIKPVIDSILSAMGKVY 318
Cdd:COG5809 278 AHEIRNPLTSLKGfiqllKDTIDEEQKTyldimlSELDRIESIISEFLVLAKPQAIKY--EPKDLNTLIEEVIPLLQPQA 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 319 RDKDIIFNCKVSDK-DYFLGDKTDLMELLGNLIDNACKACRSQVSIDVSQAKT----LSISICDDGPGIQPDKRESLlqr 393
Cdd:COG5809 356 LLKNVQIELELEDDiPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEdddkVVISVTDEGCGIPEERLKKL--- 432
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 639351759 394 GTRL-DTYESGHGVGMAIVSDLVKSYHGLLTIShSQRLGGAKFILEF 439
Cdd:COG5809 433 GEPFyTTKEKGTGLGLMVSYKIIEEHGGKITVE-SEVGKGTTFSITL 478
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-428 |
2.42e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 43.16 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACKAC---------RSQVSIDVSQAKT-----LSISICDDGPGIQPDKRESLLQrgTRLDTYESGHGVG 407
Cdd:cd16918 1 LIQVFLNLVRNAAQALagsggeiilRTRTQRQVTLGHPrhrlaLRVSVIDNGPGIPPDLQDTIFY--PMVSGRENGTGLG 78
|
90 100
....*....|....*....|.
gi 639351759 408 MAIVSDLVKSYHGLLTIsHSQ 428
Cdd:cd16918 79 LAIAQNIVSQHGGVIEC-DSQ 98
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
125-431 |
2.81e-05 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 46.44 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 125 NNTAYWQLSlTVILNNIDQ-----SEQARFI--LLKRNDALLRLMDGFKQTLVDWMFIMGIAiaGLMAIGFI-WS----- 191
Cdd:PRK11466 279 DSEISNHLQ-TLAQNNIAQfaqfsSEVSQLVdtIELRNQHGLAHLEKASARGQYSLLLLGMV--SLCALILIlWRvvyrs 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 192 -ARPLQRLDKEIKAIESGDIQ----EIKGLYpvELQTI----------------------------KADLN-LLLESQQR 237
Cdd:PRK11466 356 vTRPLAEQTQALQRLLDGDIDspfpETAGVR--ELDTIgrlmdafrsnvhalnrhreqlaaqvkarTAELQeLVIEHRQA 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 238 QKERYRAS------LSDLAHALKTPL-------AVLKSSPLANDA--------DAQEQLDRI-NVMIEHQLKRAatGASD 295
Cdd:PRK11466 434 RAEAEKASqaksafLAAMSHEIRTPLygilgtaQLLADNPALNAQrddlraitDSGESLLTIlNDILDYSAIEA--GGKN 511
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 296 TWKKQTPIKP--VIDSILSAMGKVYRDKDIIFNCKVSDK--DYFLGDKTDLMELLGNLIDNACKACRSQVSIDVSQAKTL 371
Cdd:PRK11466 512 VSVSDEPFEPrpLLESTLQLMSGRVKGRPIRLATDIADDlpTALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGE 591
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 639351759 372 S--ISICDDGPGIQPDKRESLLQRGTRLDTYESGHGVGMAIVSDLVKSYHGLLTISHSQRLG 431
Cdd:PRK11466 592 QwlVEVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVG 653
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
338-431 |
4.37e-05 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 45.59 E-value: 4.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 338 DKTDLMELLGNLIDNACKAC------RSQVSIDVS-QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYESG-HGVGMA 409
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASlrsdegNKIVELFLSdEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGeHGIGLY 508
|
90 100
....*....|....*....|..
gi 639351759 410 IVSDLVKSYHGLLTISHSQRLG 431
Cdd:PRK15053 509 LIASYVTRCGGVITLEDNDPCG 530
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
340-425 |
5.30e-05 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 42.20 E-value: 5.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 340 TDLMELLGNLIDNA---CKACRSQVSIDVS---QAKTLSISI---CDdgpgiqPDKRESLLQRGTRLDtyESGHGVGMAI 410
Cdd:pfam14501 4 VDLCVIFGNLLDNAieaCSKIDDNRFIRLKireKQNFLIIRIentYE------GELKFEGKLPSTKTK--GDGHGIGLKS 75
|
90
....*....|....*
gi 639351759 411 VSDLVKSYHGLLTIS 425
Cdd:pfam14501 76 IRRIVKKYGGNLSTE 90
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-438 |
5.57e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 42.17 E-value: 5.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACK-ACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQR----GTRLDTYESGHGVGMAIVSD 413
Cdd:cd16953 1 LGQVLRNLIGNAISfSPPDTGRITVSampTGKMVTISVEDEGPGIPQEKLESIFDRfyteRPANEAFGQHSGLGLSISRQ 80
|
90 100
....*....|....*....|....*...
gi 639351759 414 LVKSYHGLLT---ISHSQRLGGAKFILE 438
Cdd:cd16953 81 IIEAHGGISVaenHNQPGQVIGARFTVQ 108
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
342-439 |
4.52e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 39.49 E-value: 4.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 342 LMELLGNLIDNACKACRSQVSIDVSQAKTLS---ISICDDGPGIQPDKRESLLQRGTRLDTY----ESGHGVGMAIVSDL 414
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESgarLSVEDTGPGIPPEHIPRLTERFYRVDIErcrnTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 639351759 415 VKSYHGLLTIShSQRLGGAKFILEF 439
Cdd:cd16952 81 MSRHDARLLIA-SELGKGSRFTCLF 104
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
232-445 |
1.04e-03 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 41.49 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 232 LESQQRQKERYrASLSDL----AHALKTPLAVL-----------------KSSPLANdadaqEQLDRINVMIEHQLKRAA 290
Cdd:PRK11360 377 LQRRVARQERL-AALGELvagvAHEIRNPLTAIrgyvqiwrqqtsdppsqEYLSVVL-----REVDRLNKVIDQLLEFSR 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 291 TGASDTWKKQtpIKPVIDSILSAMGKVYRDKDIIFNCKV-SDKDYFLGDKTDLMELLGNLIDNACKAC--RSQVSIDVSQ 367
Cdd:PRK11360 451 PRESQWQPVS--LNALVEEVLQLFQTAGVQARVDFETELdNELPPIWADPELLKQVLLNILINAVQAIsaRGKIRIRTWQ 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 368 AK--TLSISICDDGPGIQPDkresLLQRgtRLD----TYESGHGVGMAIVSDLVKSYHGLLTIShSQRLGGAKFILEFNY 441
Cdd:PRK11360 529 YSdgQVAVSIEDNGCGIDPE----LLKK--IFDpfftTKAKGTGLGLALSQRIINAHGGDIEVE-SEPGVGTTFTLYLPI 601
|
....
gi 639351759 442 HEKK 445
Cdd:PRK11360 602 NPQG 605
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-425 |
5.40e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 36.72 E-value: 5.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639351759 334 YFLGDKTDLMELLGNLIDNACKACRSQVSIDVS---QAKTLSISICDDGPGIQPDKRESLLQRGTRLDTYES----GHGV 406
Cdd:cd16947 13 YANANTEALQRILKNLISNAIKYGSDGKFLGMTlreDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNsakqGNGL 92
|
90
....*....|....*....
gi 639351759 407 GMAIVSDLVKSYHGLLTIS 425
Cdd:cd16947 93 GLTITKRLAESMGGSIYVN 111
|
|
| |
