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Conserved domains on  [gi|639683839|ref|WP_024718443|]
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MULTISPECIES: alpha/beta hydrolase [Bacillus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10785415)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YpfH COG0400
Predicted esterase [General function prediction only];
14-203 9.96e-61

Predicted esterase [General function prediction only];


:

Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 188.19  E-value: 9.96e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  14 KPVLLMLHGTGGTEQDLLPLAEVVD-PEASVLSVRGNVSE-NGMPRFFR-RLAEGVFDEQDLIERTEELYTFIGEAADKY 90
Cdd:COG0400    5 APLVVLLHGYGGDEEDLLPLAPELAlPGAAVLAPRAPVPEgPGGRAWFDlSFLEGREDEEGLAAAAEALAAFIDELEARY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  91 GFDRHNVVAIGYSNGANIAGSLLFHYGDALKGAILHHPMVP---RRGVSLPSLAGKQVFIAAGENDPMCRPEESQELEQL 167
Cdd:COG0400   85 GIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYLPgeeALPAPEAALAGTPVFLAHGTQDPVIPVERAREAAEA 164

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 639683839 168 LQEAGASVTLHWENRGHQLTREEVDAAALWYRRQFK 203
Cdd:COG0400  165 LEAAGADVTYREYPGGHEISPEELADARAWLAERLA 200
 
Name Accession Description Interval E-value
YpfH COG0400
Predicted esterase [General function prediction only];
14-203 9.96e-61

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 188.19  E-value: 9.96e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  14 KPVLLMLHGTGGTEQDLLPLAEVVD-PEASVLSVRGNVSE-NGMPRFFR-RLAEGVFDEQDLIERTEELYTFIGEAADKY 90
Cdd:COG0400    5 APLVVLLHGYGGDEEDLLPLAPELAlPGAAVLAPRAPVPEgPGGRAWFDlSFLEGREDEEGLAAAAEALAAFIDELEARY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  91 GFDRHNVVAIGYSNGANIAGSLLFHYGDALKGAILHHPMVP---RRGVSLPSLAGKQVFIAAGENDPMCRPEESQELEQL 167
Cdd:COG0400   85 GIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYLPgeeALPAPEAALAGTPVFLAHGTQDPVIPVERAREAAEA 164

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 639683839 168 LQEAGASVTLHWENRGHQLTREEVDAAALWYRRQFK 203
Cdd:COG0400  165 LEAAGADVTYREYPGGHEISPEELADARAWLAERLA 200
PRK11460 PRK11460
putative hydrolase; Provisional
 2-194 2.64e-05

putative hydrolase; Provisional


Pssm-ID: 183144 [Multi-domain]  Cd Length: 232  Bit Score: 43.49  E-value: 2.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839   2 MKH---LFQKGKNEQKPVLLMLHGTGGTEQDLLPLAEVVD---PEASVLSVRGnVSENGMPRFFRRLAEGVFDEQDLIER 75
Cdd:PRK11460   1 MKHdhfVVQSPDKPAQQLLLLFHGVGDNPVAMGEIGSWFApafPDALVVSVGG-PEPSGNGAGRQWFSVQGITEDNRQAR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  76 TEE-LYTFIG---EAADKYGFDRHNVVAIGYSNGANIagsllfhygdALKGAILHHPMVPR------RGVSLPSLAGKQV 145
Cdd:PRK11460  80 VAAiMPTFIEtvrYWQQQSGVGASATALIGFSQGAIM----------ALEAVKAEPGLAGRviafsgRYASLPETAPTAT 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 639683839 146 FI--AAGENDPMCRPEESQELEQLLQEAGASVTLH-WENRGHQLTREEVDAA 194
Cdd:PRK11460 150 TIhlIHGGEDPVIDVAHAVAAQEALISLGGDVTLDiVEDLGHAIDPRLMQFA 201
DLH pfam01738
Dienelactone hydrolase family;
93-202 1.48e-04

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 41.18  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839   93 DRHNVVAIGYSNGANIAgSLLFHYGDALKGAILHHPMVPRRGVSLPSLAGKQVFIAAGENDPMCRPEESQELEQLLQEAG 172
Cdd:pfam01738  94 SPKKVGVVGYCMGGALA-VLLAAKGPLVDAAVGFYGVGPEPPLIEAPDIKAPILFHFGEEDHFVPADSRELIEEALKAAN 172

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 639683839  173 ASVTLHW-ENRGHQLTREEVD-----AAALWYRRQF 202
Cdd:pfam01738 173 VDHQIHSyPGAGHAFANDSRPsynaaAAEDAWERTL 208
 
Name Accession Description Interval E-value
YpfH COG0400
Predicted esterase [General function prediction only];
14-203 9.96e-61

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 188.19  E-value: 9.96e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  14 KPVLLMLHGTGGTEQDLLPLAEVVD-PEASVLSVRGNVSE-NGMPRFFR-RLAEGVFDEQDLIERTEELYTFIGEAADKY 90
Cdd:COG0400    5 APLVVLLHGYGGDEEDLLPLAPELAlPGAAVLAPRAPVPEgPGGRAWFDlSFLEGREDEEGLAAAAEALAAFIDELEARY 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  91 GFDRHNVVAIGYSNGANIAGSLLFHYGDALKGAILHHPMVP---RRGVSLPSLAGKQVFIAAGENDPMCRPEESQELEQL 167
Cdd:COG0400   85 GIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSGYLPgeeALPAPEAALAGTPVFLAHGTQDPVIPVERAREAAEA 164

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 639683839 168 LQEAGASVTLHWENRGHQLTREEVDAAALWYRRQFK 203
Cdd:COG0400  165 LEAAGADVTYREYPGGHEISPEELADARAWLAERLA 200
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
61-203 1.96e-12

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 63.35  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  61 RLA-EGVFDEQdlIERTEELYTFIGEAADKYGFDRHNVVAIGYSNGANIAGSLLFHYGD----ALKGAILHHPMV----- 130
Cdd:COG0657   53 RLApEHPFPAA--LEDAYAALRWLRANAAELGIDPDRIAVAGDSAGGHLAAALALRARDrggpRPAAQVLIYPVLdltas 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839 131 P-RRGVS-LPSlagkqVFIAAGENDPMCrpEESQELEQLLQEAGASVTLH-WENRGH--------QLTREEVDAAALWYR 199
Cdd:COG0657  131 PlRADLAgLPP-----TLIVTGEADPLV--DESEALAAALRAAGVPVELHvYPGGGHgfgllaglPEARAALAEIAAFLR 203


                 ....
gi 639683839 200 RQFK 203
Cdd:COG0657  204 RALA 207
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
15-184 2.30e-08

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 52.93  E-value: 2.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  15 PVLLMLHGTGGTEQD---LLPLAEVVD--------PEASVLSVRGNVSEN------GMPRFFRRLAEgvfdeqDLIERTE 77
Cdd:COG2382  113 PVLYLLDGGGGDEQDwfdQGRLPTILDnliaagkiPPMIVVMPDGGDGGDrgtegpGNDAFERFLAE------ELIPFVE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  78 ELYTFIGEAAdkygfdrHNVVAiGYSNGANIAGSLLFHYGD------ALKGAILHHPMVPRRGVSLPSLAGKQ------V 145
Cdd:COG2382  187 KNYRVSADPE-------HRAIA-GLSMGGLAALYAALRHPDlfgyvgSFSGSFWWPPGDADRGGWAELLAAGApkkplrF 258

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 639683839 146 FIAAGENDPMcrPEESQELEQLLQEAGASVTLHWENRGH 184
Cdd:COG2382  259 YLDVGTEDDL--LEANRALAAALKAKGYDVEYREFPGGH 295
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
10-203 1.07e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 50.40  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  10 KNEQKPVLLMLHGTGGT-EQDLLPLAEVVdpeAS----VLSV--RGN-VSENGMprffrrlaeGVFDEQDLIerteelyT 81
Cdd:COG1506   19 DGKKYPVVVYVHGGPGSrDDSFLPLAQAL---ASrgyaVLAPdyRGYgESAGDW---------GGDEVDDVL-------A 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  82 FIGEAADKYGFDRHNVVAIGYSNGANIAGSLLFHYGDALKGAILHHPMV------------PRRGVSLPSLAGKQ----- 144
Cdd:COG1506   80 AIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSdlrsyygttreyTERLMGGPWEDPEAyaars 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639683839 145 -----------VFIAAGENDPMCRPEESQELEQLLQEAGASVTLHW-ENRGHQLTREE----VDAAALWYRRQFK 203
Cdd:COG1506  160 playadklktpLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVyPGEGHGFSGAGapdyLERILDFLDRHLK 234
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
12-196 1.55e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 44.22  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  12 EQKPVLLMLHGTGGTEQDLLPLAEV-VDPEASVLSV--RGNVSENGMPRFFRRLAEGVFDEQDLIERTEELYtfigeaad 88
Cdd:COG2267   26 SPRGTVVLVHGLGEHSGRYAELAEAlAAAGYAVLAFdlRGHGRSDGPRGHVDSFDDYVDDLRAALDALRARP-------- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  89 kygfdRHNVVAIGYSNGANIAGSLLFHYGDALKGAILHHPMV---PRRGVSLPSLAGKQ-----------VFIAAGENDP 154
Cdd:COG2267   98 -----GLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYradPLLGPSARWLRALRlaealaridvpVLVLHGGADR 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 639683839 155 MCRPEESqelEQLLQEAGASVTLH-WENRGHQLTREEVDAAAL 196
Cdd:COG2267  173 VVPPEAA---RRLAARLSPDVELVlLPGARHELLNEPAREEVL 212
PRK11460 PRK11460
putative hydrolase; Provisional
 2-194 2.64e-05

putative hydrolase; Provisional


Pssm-ID: 183144 [Multi-domain]  Cd Length: 232  Bit Score: 43.49  E-value: 2.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839   2 MKH---LFQKGKNEQKPVLLMLHGTGGTEQDLLPLAEVVD---PEASVLSVRGnVSENGMPRFFRRLAEGVFDEQDLIER 75
Cdd:PRK11460   1 MKHdhfVVQSPDKPAQQLLLLFHGVGDNPVAMGEIGSWFApafPDALVVSVGG-PEPSGNGAGRQWFSVQGITEDNRQAR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  76 TEE-LYTFIG---EAADKYGFDRHNVVAIGYSNGANIagsllfhygdALKGAILHHPMVPR------RGVSLPSLAGKQV 145
Cdd:PRK11460  80 VAAiMPTFIEtvrYWQQQSGVGASATALIGFSQGAIM----------ALEAVKAEPGLAGRviafsgRYASLPETAPTAT 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 639683839 146 FI--AAGENDPMCRPEESQELEQLLQEAGASVTLH-WENRGHQLTREEVDAA 194
Cdd:PRK11460 150 TIhlIHGGEDPVIDVAHAVAAQEALISLGGDVTLDiVEDLGHAIDPRLMQFA 201
DLH pfam01738
Dienelactone hydrolase family;
93-202 1.48e-04

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 41.18  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839   93 DRHNVVAIGYSNGANIAgSLLFHYGDALKGAILHHPMVPRRGVSLPSLAGKQVFIAAGENDPMCRPEESQELEQLLQEAG 172
Cdd:pfam01738  94 SPKKVGVVGYCMGGALA-VLLAAKGPLVDAAVGFYGVGPEPPLIEAPDIKAPILFHFGEEDHFVPADSRELIEEALKAAN 172

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 639683839  173 ASVTLHW-ENRGHQLTREEVD-----AAALWYRRQF 202
Cdd:pfam01738 173 VDHQIHSyPGAGHAFANDSRPsynaaAAEDAWERTL 208
PRK10566 PRK10566
esterase; Provisional
 137-201 4.71e-04

esterase; Provisional


Pssm-ID: 182555 [Multi-domain]  Cd Length: 249  Bit Score: 39.97  E-value: 4.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639683839 137 LPSLAGKQVFIAAGENDPMCRPEESQELEQLLQEAG--ASVTLHWE-NRGHQLTREEVDAAALWYRRQ 201
Cdd:PRK10566 181 LEQLADRPLLLWHGLADDVVPAAESLRLQQALRERGldKNLTCLWEpGVRHRITPEALDAGVAFFRQH 248
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 12-195 5.25e-04

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 39.60  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  12 EQKPVLLMLHGTGGTEQDLLPLAEVVDPEASVLSV--RGnvseNGmprfFRRLAEGVFDEQDLIERTEELytfigeaADK 89
Cdd:COG0596   21 PDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPdlRG----HG----RSDKPAGGYTLDDLADDLAAL-------LDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839  90 YGFDRhnVVAIGYSNGANIAGSLLFHYGDALKGAIL-------HHPMVPRRGVSLPSLAGKQ------------------ 144
Cdd:COG0596   86 LGLER--VVLVGHSMGGMVALELAARHPERVAGLVLvdevlaaLAEPLRRPGLAPEALAALLralartdlrerlaritvp 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 639683839 145 VFIAAGENDPMCRPEESQELEQLLQEAgasvTLHW-ENRGHQLTREEVDAAA 195
Cdd:COG0596  164 TLVIWGEKDPIVPPALARRLAELLPNA----ELVVlPGAGHFPPLEQPEAFA 211
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 9-125 1.00e-03

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 39.45  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639683839    9 GKNEQKPVLLMLHGTGGTEQDLLPLAEVVDPEASVLSVrgNVSENGMPRFFRRLAEGVFDEQDLIERTEE-LYTFIGEAA 87
Cdd:PLN02980 1366 GQNAEGSVVLFLHGFLGTGEDWIPIMKAISGSARCISI--DLPGHGGSKIQNHAKETQTEPTLSVELVADlLYKLIEHIT 1443

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 639683839   88 DKygfdrhNVVAIGYSNGANIAGSLLFHYGDALKGAIL 125
Cdd:PLN02980 1444 PG------KVTLVGYSMGARIALYMALRFSDKIEGAVI 1475
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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