|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-417 |
1.22e-46 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 165.42 E-value: 1.22e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAP 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRF-GRKRVFLIGLALFGLASLLCA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPF 173
Cdd:cd17321 80 LAPSLAFLIAARALQGIGAAAIMPASLALIAATFpGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 174 ILISFFLGlslfpkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdep 253
Cdd:cd17321 160 GLVALLLA------------------------------------------------------------------------ 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 254 fiqirmfrqeKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHPV 333
Cdd:cd17321 168 ----------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVL 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 334 LASAVLMLAGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLG 413
Cdd:cd17321 238 VAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
....
gi 639685059 414 MLFG 417
Cdd:cd17321 318 ALLT 321
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-408 |
8.93e-44 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 157.06 E-value: 8.93e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 1 MIKWKNNRKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFL 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 81 FGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMT 159
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 160 IGSWPAIFLVNLPFILISFFLGLSLFPKEKKKKLRigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqgilclvs 239
Cdd:COG2814 160 LFGWRWVFLVNAVLALLALLLLLRLLPESRPAARA--------------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 240 agafiwweyqvdEPFIQIRMFRQEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPL 319
Cdd:COG2814 195 ------------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 320 TGKWVDRGDERHPVLASAVLMLAGASAMTFFfipAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQT 399
Cdd:COG2814 263 AGRLADRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNS 339
|
....*....
gi 639685059 400 CRYLGSILS 408
Cdd:COG2814 340 AFFLGGPLA 348
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-450 |
3.87e-39 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 145.41 E-value: 3.87e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAP 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRF-GTRRLFLTALALFTLGSLLCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPF 173
Cdd:cd17503 80 LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYpPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 174 ILISFFLGlslfpkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdeP 253
Cdd:cd17503 160 GILALLLA-----------------------------------------------------------------------P 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 254 FIQIRMFRqEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHPV 333
Cdd:cd17503 169 LLDLRLFK-DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLL 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 334 LASAVLMLAGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLG 413
Cdd:cd17503 248 LAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLA 327
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 639685059 414 MLFGEEIAGSHFEQLGWTLIMIS----LVGISVSLYFSSMV 450
Cdd:cd17503 328 TLLTNRTQFHHSRLSELLAQQVQkqalIIAFNDAFLVSAIL 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-416 |
3.69e-35 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 134.24 E-value: 3.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAP 94
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPF 173
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEErGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 174 ILISFFLGLSLFPKEKKKKLRIGDTVRKLDLPgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdep 253
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSG------------------------------------------------ 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 254 fiqIRMFRQEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHPV 333
Cdd:cd17325 192 ---LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 334 LASAVLMlagASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLG 413
Cdd:cd17325 269 LIGLLLS---AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG 345
|
...
gi 639685059 414 MLF 416
Cdd:cd17325 346 FLY 348
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
14-404 |
4.04e-33 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 130.58 E-value: 4.04e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 14 AIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRtLFLFGLVLVAVSAICA 93
Cdd:TIGR00711 6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRR-LFLISTFAFTLGSLLC 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 94 PFAPTFAVLIVIRLLQAIGSSAIYPSGVGLI-RDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLP 172
Cdd:TIGR00711 85 GVAPNLELMIIFRVIQGFGGGPLIPLSFSTLlNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 173 FILISFFLGLSLFPKEKKKKLrigdtvRKLDLPGMFLFTVCIVLLLSFLLS------LSDGIQYVQGILCLVSAGAFIWW 246
Cdd:TIGR00711 165 IGIIVVVVAFFILPRDKPAAS------ENFDFLGLLLLSVGLGSLLYGLSEgpergwFDSNEILILSITGLVAIIAFVVW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 247 EYQVDEPFIQIRMFrQEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDR 326
Cdd:TIGR00711 239 ELTDDNPLVDLRLF-KYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDK 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639685059 327 GDERHPVLASAVLMLAGASAMTFFFIP-APFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLG 404
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFTFTPdTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLG 396
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-409 |
8.79e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 121.76 E-value: 8.79e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQ-IQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 94 PFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLP 172
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 173 FILISFFLGLSLFPKEKKKKLRIGDTVRKLdlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvde 252
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLS-------------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 253 PFIQIRMFRQEKRLSLVYVqFIILNIFFYCLFFGLPSYfQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHP 332
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRR 267
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639685059 333 VLASAVLMLAGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSS 409
Cdd:pfam07690 268 LLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
16-415 |
4.77e-30 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 119.99 E-value: 4.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 16 AFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFgLVLVAVSAICAPF 95
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIV-LAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 96 APTFAVLIVIRLLQAIGsSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFI 174
Cdd:cd17504 81 APNLPVLIAGRALQGIG-GAVFPLAFALVREEFpPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 175 LISFFLglslfpkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdEPF 254
Cdd:cd17504 160 VLLAAL-----------------------------------------------------------------------VPL 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 255 IQIRMFRQeKRLSLVYVQFIILNIFFYCLFFGLPSYFQDE----LGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDER 330
Cdd:cd17504 169 IDLRLLRR-RNVLLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPR 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 331 HPVLASAVLMLAGASAMTFFfiPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSA 410
Cdd:cd17504 248 RVLLIGLVISAVGLLLLALL--HSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPA 325
|
....*
gi 639685059 411 VLGML 415
Cdd:cd17504 326 IAGAI 330
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
3-442 |
8.18e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 116.51 E-value: 8.18e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 3 KWKNNRKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFG 82
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF-GRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 83 LVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIG 161
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 162 SWPAIFLVNlpfilisfflglslfpkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqGILCLVSAG 241
Cdd:COG2271 162 GWRAAFLIL--------------------------------------------------------------GLPGLLLAL 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 242 AFIWweyqvdepfiqirmfrqekrlsLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTG 321
Cdd:COG2271 180 LRFW----------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGG 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 322 KWVDRGDERHPVLASAVLMLAGASAMTFFFIPAPFWGkGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCR 401
Cdd:COG2271 238 WLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALA-IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 639685059 402 YLGSILSSAVLGMLfgeeiagshFEQLGWTLIMISLVGISV 442
Cdd:COG2271 317 FLGGALGPLLVGYL---------LDATGYQAAFLLLAALAL 348
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-184 |
7.88e-28 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 112.21 E-value: 7.88e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 7 NRKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLV 86
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDR-YGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 87 AVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTIGSWPA 165
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170
....*....|....*....
gi 639685059 166 IFLVNLPFILISFFLGLSL 184
Cdd:COG0477 170 IFLINAPLGLLALVLRLRL 188
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-417 |
5.26e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 111.51 E-value: 5.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 12 LTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLfLFGLVLVAVSAI 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVL-LPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 92 CAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTIgSWPAIFLVN 170
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGErAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 171 LPFILISFFLGLSLFPKEKKKKLRIGDTVRKldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqv 250
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSSSATKLR------------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 251 depfIQIRMFRQeKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDER 330
Cdd:cd17474 190 ----DLKKALRG-RGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 331 HPVLASAVLMLAGASAMtFFFIPAPFWgKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSA 410
Cdd:cd17474 265 RRILVIGLLLYALSLLL-LGFVPSLAL-LLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPL 342
|
....*..
gi 639685059 411 VLGMLFG 417
Cdd:cd17474 343 LFGLLLE 349
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-446 |
3.43e-26 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 109.18 E-value: 3.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 12 LTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAI 91
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDR-IERRRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 92 CAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVN 170
Cdd:cd17324 80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 171 LPFILISFFLGLSLFPKEKKKKLRIGDTVRkldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqv 250
Cdd:cd17324 160 AVLALLAALLLWRLLPSLPPKKPGSLGLLS-------------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 251 depfiQIRMFRQEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDER 330
Cdd:cd17324 190 -----SLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRR 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 331 HPVLASAVLMLAGasaMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPqQMIGTTSGLFQTCRYLGSILSSA 410
Cdd:cd17324 265 ALLIALLLLAAAL---LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAA 340
|
410 420 430
....*....|....*....|....*....|....*.
gi 639685059 411 VLGMLFgeeiagSHFEQLGWTLIMISLVGISVSLYF 446
Cdd:cd17324 341 LGGLVL------DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
18-407 |
9.93e-23 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 98.79 E-value: 9.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 18 GTMLNPLNSSMISLALHQIQHEFGlSFTTVSWLISTFYLASAVTQPVSGRIGDhVMSRRTLFLFGLVLVAV-SAICApFA 96
Cdd:cd17502 4 ALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSD-LFGRKWVLLIAIVIFELgSLLCG-LA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 97 PTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASAL-AVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFIL 175
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYqGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 176 ISFFLglslfpkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdepfi 255
Cdd:cd17502 161 LALAL--------------------------------------------------------------------------- 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 256 qIRMFrqekrlSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDR-GDERHPVL 334
Cdd:cd17502 166 -LRTI------LLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtGRYKPLIV 238
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639685059 335 ASAVLMLAGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSIL 407
Cdd:cd17502 239 IGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTL 311
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
15-418 |
6.63e-22 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 96.88 E-value: 6.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAP 94
Cdd:cd17320 4 LALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRF-GRRPVLLAGLLLFILASLLCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPF 173
Cdd:cd17320 83 LASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAElAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 174 ILISFFLGLsLFPKEKKKKLRIGDTVRKLdlpgmflftvcivlllsfllslsdgiqyvqgilclvsAGAFiwweyqvdep 253
Cdd:cd17320 163 GLLLLLLVL-LFLPETLPEEKRKPLLSSL-------------------------------------LRAY---------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 254 fiqIRMFRQekRLSLVYVQFIILNI-FFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHP 332
Cdd:cd17320 195 ---KRVLKN--RRFLGYALALGLSFaGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 333 VLASAVLMLAGASAM--TFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPqQMIGTTSGLFQTCRYLGSILSSA 410
Cdd:cd17320 270 LRLGLLLLLAAALVLllAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGA 348
|
....*...
gi 639685059 411 VLGMLFGE 418
Cdd:cd17320 349 LVGLLPNG 356
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
38-416 |
4.89e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 94.20 E-value: 4.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 38 HEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIY 117
Cdd:cd17489 24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF-GRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFT 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 118 PSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLSL-FPKEKKKKLRi 195
Cdd:cd17489 103 TAAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVkDPPPVAAEEA- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 196 gdtvrkldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdEPFIQIRMFRQEKRLSLVYVQFII 275
Cdd:cd17489 182 --------------------------------------------------------EAGTRAFRRLVEKKVLPPALILFL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 276 LNIFFYCLFFGLPSYFqDELGWrvEMTGLFMLCMSGMSIMVSPLTGKWVDRGderHPVLASAVLMLAGASAMTFFFIPAP 355
Cdd:cd17489 206 ASIAYGAISTFLPLYA-AERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRK---GPKTVIIPGLLLLALGLLLLSFAGS 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639685059 356 FWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLGMLF 416
Cdd:cd17489 280 PWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVA 340
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
6-453 |
7.29e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 94.18 E-value: 7.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 6 NNRKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVL 85
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDR-FGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 86 VAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWP 164
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 165 AIFLVNLPFILISFFLgLSLFPKEKKKKLRIGDTVRKLDLPGMFlftvcivlllsfllslSDGIQYVQGILCLVSAGAFI 244
Cdd:COG2223 160 NAFLILGILLLVVAVL-AWLFLRDPPAGAAAAAKASLRDQLEAL----------------RDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 245 wweyqvdepfiqirmfrqekrlslvyvqfiilniffyCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWV 324
Cdd:COG2223 223 -------------------------------------GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLS 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 325 DRGDERHPVLASAVLMLAGasAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFqtcrYLG 404
Cdd:COG2223 266 DRIGGRRVLLIVFALMALG--LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLV----GAA 339
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 639685059 405 SILSSAVLGMLFGEEIAGSHFEQLGWTLIMI-SLVGISVSLYFSSMVRGK 453
Cdd:COG2223 340 GGLGGFLGPLLFGALLDATGSYTAAFLVFAVlALVALVLTLLLYRRPRRA 389
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
29-456 |
3.66e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 89.16 E-value: 3.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 29 ISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLfGLVLVAVSAICAPFAPTFAVLIVIRLL 108
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLL-ALLLLAAGLLLRSLAPSVALLLAGTAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 109 QAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLSLFPKE 188
Cdd:COG2807 116 IGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 189 KKKKLRIGDTVRKldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdepfiqIRMFRQeKRLSL 268
Cdd:COG2807 196 PAAAAAAPAAASL-------------------------------------------------------RSLWRS-PLAWL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 269 VYVQFIILNIFFYCLFFGLPSYFQDeLGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDR-GDERHPVLASAVLMLAGASAM 347
Cdd:COG2807 220 LTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRlGDRRPLLLLLGLLGLAGLLGL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 348 TFffipAPFWGKGLVLALLGLSYGIGN-VALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLGMLFgeEIAGShfe 426
Cdd:COG2807 299 LL----APGSLPWLWAVLLGLGQGGLFpLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALH--DATGS--- 369
|
410 420 430
....*....|....*....|....*....|
gi 639685059 427 qlgWTLIMISLVGISVSLYFSSMVRGKQTM 456
Cdd:COG2807 370 ---WTAALLLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-416 |
4.74e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.64 E-value: 4.74e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAP 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTI--GSWPAIFLVNL 171
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERErGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 172 PFILISFFLGLSLFPKEKKKKLRIGDTVRKLdlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvd 251
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSK------------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 252 EPFIQIRMFRQEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERH 331
Cdd:cd06174 191 SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRK 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 332 PVLASAVLMLAGasAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAV 411
Cdd:cd06174 271 PLLLIGLLLMAL--GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348
|
....*
gi 639685059 412 LGMLF 416
Cdd:cd06174 349 AGFLL 353
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
12-415 |
4.27e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 82.62 E-value: 4.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 12 LTAIAFGTMLNPLNSSMISLALHQIQHEF-GLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSA 90
Cdd:cd17473 1 LITLLLASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRF-GRKRLLIAGLLLYGIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 91 ICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDH-VKERQASALAVLSIFASAMTALGPTLGGFLMTIGsWPAIFLV 169
Cdd:cd17473 80 VAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYfEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIG-WRAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 170 NLPFILISFFLGLSLFPKEKKKKlrigdtvrkldlpgmflftvcivlllsfllslsdgiqyVQGILCLVSAGAFIWweyq 249
Cdd:cd17473 159 YLLALPVLILVLLFLPEPARKSK--------------------------------------SAASPGAATAAALPW---- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 250 vdepfiqirmfrqeKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDE 329
Cdd:cd17473 197 --------------KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 330 RHPVLASAVLMlagASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSS 409
Cdd:cd17473 263 RRLLAIGFALM---ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSP 339
|
....*.
gi 639685059 410 AVLGML 415
Cdd:cd17473 340 LVLGPL 345
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
15-215 |
5.23e-17 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 82.22 E-value: 5.23e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAP 94
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADR-KPRRYLLPLGPLLTGLGLSLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFI 174
Cdd:cd17478 80 FAPNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPG 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 639685059 175 LISFFLGLSLFP-----KEKKKKLRIGDTVRKLDLPGMFLFTVCIV 215
Cdd:cd17478 160 LAVALLLLRLRPlkkpeAKKAAAKSSARSTLKGVWRALLLLLIIVF 205
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
14-411 |
2.45e-16 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 81.13 E-value: 2.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 14 AIAFGTMLNPLNSSMISLALHQIQHEFGLSfTTVSWLISTFYLASAVTQPVSGRIGDhVMSRRTLFLFGLVLVAVSAICA 93
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSD-LFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 94 PFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLM--TIGSWPAIFLVNL 171
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 172 PFILISFFL-GLSLFPKEKKKKLRIGDT--VRKLDLPGMFLFTVCIVLLLSFLLSLsdGIQY-----------VQGILCL 237
Cdd:cd06179 160 IFNALALILlFFFYHPPPRPQLHGSSTRqkLKRLDWVGLFLLIAGLVLFLLGLSWG--GNPYpwssahviaplVIGGVLL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 238 VsaGAFIWWEYQVDEPFIQIRMFRQEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVS 317
Cdd:cd06179 238 I--AFGLYEWKGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 318 PLTGKWVDR-GDERHPVLASAVLMLAGASAMtffFIPAPFwGKGLVLALLGLSyGIG-NVALQAAMLKAS---PQQMIGT 392
Cdd:cd06179 316 ILAGLLLTKiKHIKWQLVAGFVLFTAFLALL---ALITPD-NKALAIAFSVLA-GIGiGGPLVLAIVIVQlsvPPEDIGT 390
|
410
....*....|....*....
gi 639685059 393 TSGLFQTCRYLGSILSSAV 411
Cdd:cd06179 391 ASGLLGSARALGGAVGTAI 409
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
41-415 |
5.52e-16 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 80.16 E-value: 5.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 41 GLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLfGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSG 120
Cdd:PRK14995 37 GASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLML-GGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPAT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 121 VGLIRD-HVKERQAS-ALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLSLFPKEKkkklriGDT 198
Cdd:PRK14995 116 LAGIRAtFTEEKQRNmALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQA------GRR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 199 VRKLDLPGMFLFTVCIVLLLSFLLSLSDGIQYVQGILCLVSAGA-----FIWWEYQVDEPFIQIRMFRQEKRLSLVYVQF 273
Cdd:PRK14995 190 DQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGAlllglFIRTQLAASRPMIDMRLFTHRIILSGVVMAM 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 274 --IILNIFFYCLffgLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERhPVLASAVLMlagaSAMTFF- 350
Cdd:PRK14995 270 taMITLVGFELL---MAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLR-LVATGGMAL----SALSFYg 341
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639685059 351 -----FIPAPFWGKGLvLALLGLSYGIGNVALQAAMLKASPQQMiGTTSGLFQTCRY-LGSILSSAVLGML 415
Cdd:PRK14995 342 lamtdFSTQQWQAWGL-MALLGFSAASALLASTSAIMAAAPPEK-AAAAGAIETMAYeLGAGLGIAIFGLL 410
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
15-186 |
7.55e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 72.61 E-value: 7.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDhVMSRRTLFLFGLVLVAVSAICAP 94
Cdd:cd17323 4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSE-LYGRRPVYLVSLFIFVIFQIGCA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQA-SALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPF 173
Cdd:cd17323 83 LAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERgKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAII 162
|
170
....*....|...
gi 639685059 174 ILISFFLGLSLFP 186
Cdd:cd17323 163 SGFCLILIFLFLP 175
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
12-416 |
2.18e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 71.06 E-value: 2.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 12 LTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAI 91
Cdd:cd17319 5 IPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTAL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 92 CApFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRD-HVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFlvn 170
Cdd:cd17319 85 TG-FATSLTSLYVLRFLLGVAEAGFFPGAIKALAEwFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF--- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 171 lpfilisfflglslfpkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqYVQGILCLVSagAFIWWEYqv 250
Cdd:cd17319 161 -----------------------------------------------------------IIEGLLGLLL--AVLWWFY-- 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 251 depfiqirmfrqEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDER 330
Cdd:cd17319 178 ------------LRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 331 HPVLASAVLMLAGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSA 410
Cdd:cd17319 246 ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPL 325
|
....*.
gi 639685059 411 VLGMLF 416
Cdd:cd17319 326 LIGYLV 331
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
15-417 |
9.83e-13 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 69.76 E-value: 9.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 15 IAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAP 94
Cdd:PRK10504 15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRV-GVRNIFFTAIVLFTLGSLFCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 95 FAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPF 173
Cdd:PRK10504 94 LSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVpREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 174 ILISFFLGLSLFPKEKKKklrigdtVRKLDLPGMFLFTVCIvlllSFLLSLSDG--------IQYVQGILCLVSAGAFIW 245
Cdd:PRK10504 174 GIIGAIATLMLMPNYTMQ-------TRRFDLSGFLLLAVGM----ATLTLALDGskglglspLAIAGLVAVGVVALLLYL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 246 WEYQVDE-PFIQIRMFRQeKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWV 324
Cdd:PRK10504 243 LHARNNNrALFSLKLFRT-RTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 325 DRGDERHpVLASAVLMLAGASAM-TFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYL 403
Cdd:PRK10504 322 NRFGYRR-VLVATTLGLALVSLLfMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQL 400
|
410
....*....|....
gi 639685059 404 GSILSSAVLGMLFG 417
Cdd:PRK10504 401 SMSIGVTIAGLLLG 414
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-190 |
5.48e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 66.82 E-value: 5.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 11 FLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRR-TLFLFGLVLVAVS 89
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRkLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 90 AICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFL 168
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|..
gi 639685059 169 VNLPFILISFFLGLSLFPKEKK 190
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
47-416 |
1.31e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 66.10 E-value: 1.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 47 VSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAICAPFA----PTFAVLIVIRLLQAIGSSAIYPSGVG 122
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgsLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 123 LIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLSLFPKEKKKKLRigdtvrk 201
Cdd:cd06173 116 LLPELVPKEQlVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGE------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 202 ldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafiWWEYQVDEPFIQIRMFRQEKRLSLVYVQFIILNIFFY 281
Cdd:cd06173 189 -------------------------------------------SSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 282 CLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRgdeRHPVLASAVLMLAGASAMTFFFIPAPFWGKGL 361
Cdd:cd06173 226 ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR---RRRGRLLLIGALLLGLALLVLGLSPSLWLLLA 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 639685059 362 VLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLGMLF 416
Cdd:cd06173 303 ALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-192 |
4.91e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 64.10 E-value: 4.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 5 KNNRKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLfLFGLV 84
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL-LLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 85 LVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIG--- 161
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGlsl 161
|
170 180 190
....*....|....*....|....*....|..
gi 639685059 162 SWPAIFLVN-LPFILISFFLGLSLFPKEKKKK 192
Cdd:COG0738 162 SWHLPYLILaVLLLLLALLFLRSKLPEIEEEE 193
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
8-195 |
8.40e-11 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 63.56 E-value: 8.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 8 RKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDhVMSRRTLFLFGLVLVA 87
Cdd:TIGR00710 3 AKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSD-RYGRRPVLLLGLFIFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 88 VSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASAL-AVLSIFASAMTALGPTLGGFLMTIGSWPAI 166
Cdd:TIGR00710 82 LSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIySILMPVLALAPAVAPLLGGYILVWLSWHAI 161
|
170 180 190
....*....|....*....|....*....|...
gi 639685059 167 F----LVNLPFILISFFLGLSLFPKEKKKKLRI 195
Cdd:TIGR00710 162 FaflsLAGILLSALIFFILPETLPYEARIQIST 194
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
39-417 |
3.01e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 3.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 39 EFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMS----RRTLFLFGLVLVAVSAICAPFAPT------FAVLIVIRLL 108
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrRRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 109 QAIGSSAIYPSGVGLIRD---HVKERqASALAVLSIFASAMTALGPTLGGFLMtigswpAIFLVNLPFILISFFLGLSLF 185
Cdd:COG2211 120 LGLAYTLVNIPYSALGAEltpDYEER-TRLSSWRFAFAGLGGLLASVLPPPLV------AAFGGDAALGYRLTALIFAVL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 186 pkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqGILCLVSAGAFIWWEYQVDEP----FIQIRMFR 261
Cdd:COG2211 193 -----------------------------------------------GLLAFLLTFFGTKERPVPEEEkvslKESLKALL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 262 QEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDeRHPVLASAVLML 341
Cdd:COG2211 226 KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG-KKKAFIIGLLLA 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 342 AGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASP-------QQMIGTTSGLFQTCRYLGSILSSAVLGM 414
Cdd:COG2211 305 ALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGL 384
|
...
gi 639685059 415 LFG 417
Cdd:COG2211 385 LLA 387
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
37-191 |
2.50e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 2.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 37 QHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAI 116
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639685059 117 YPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLSLFPKEKKK 191
Cdd:COG0738 317 FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
10-184 |
2.84e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.36 E-value: 2.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 10 VFLTAIAFGTMLnPLNSSMISLAlhqiqHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVS 89
Cdd:cd17330 5 VFLDALGFGIVF-PVLPFYVREF-----NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRY-GRKPVLLLSLAGSAVS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 90 AICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSwpaiflV 169
Cdd:cd17330 78 YVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG------Y 151
|
170
....*....|....*
gi 639685059 170 NLPFILISFFLGLSL 184
Cdd:cd17330 152 ALPFLVAAALALLNL 166
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
5-192 |
4.68e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 57.98 E-value: 4.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 5 KNNRKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQ----PVSGRIGdhvmsRRTLFL 80
Cdd:PRK11043 1 MQPSKGFLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQllwgPLSDRYG-----RKPVLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 81 FGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASalavlSIFASAM------TALGPTLG 154
Cdd:PRK11043 76 AGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKAN-----RVFATIMplvalsPALAPLLG 150
|
170 180 190
....*....|....*....|....*....|....*...
gi 639685059 155 GFLMTIGSWPAIFLVNLPFILISFFLGLSLFPKEKKKK 192
Cdd:PRK11043 151 AWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARK 188
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
21-167 |
6.45e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 57.66 E-value: 6.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 21 LNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDhVMSRRTLFLFGLVLVAVSAICAPFAPTFA 100
Cdd:cd17476 9 LNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGD-IYGHKKMFVIGSFWFAIWSLIAGFSPNFI 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639685059 101 VLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAMT--ALGPTLGGFLMTIGSWPAIF 167
Cdd:cd17476 88 FFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLgfALGGVFGGLFAQLAWWPWIF 156
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-440 |
7.58e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.28 E-value: 7.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 29 ISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLL 108
Cdd:cd17312 22 FSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDR-SNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 109 QAIGSSAIYPSGVGLIRD--HVKERqASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFlvnlpfilisfflglslfp 186
Cdd:cd17312 101 NGLFQSMGWPPCVKLLGNwfSKKER-GTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF------------------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 187 kekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqYVQGILCLVsAGAFIWWEYQVDEPFIQIrmfrqekrL 266
Cdd:cd17312 161 -------------------------------------------LVPGIVGLV-VAIILFFFLRDSPPYVWV--------L 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 267 SLVYVqfiILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDR--GDERHPVLASAVLMLAGa 344
Cdd:cd17312 189 SLAYA---FVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKlfGGRRAPIAVIYMLLMTL- 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 345 SAMTFFFIPAPFWGKGLVLALLGLS-YGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLGMLfgeeIAGS 423
Cdd:cd17312 265 SLALFWFFPHNKLLSIVLLFLIGFFvGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYI----IDHY 340
|
410
....*....|....*..
gi 639685059 424 HFEQLGWTLIMISLVGI 440
Cdd:cd17312 341 GWSTVFYFLISAALLSV 357
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
52-422 |
8.15e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 57.27 E-value: 8.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 52 STFyLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIyPSGVGLIRDHV-KE 130
Cdd:cd17391 44 STF-LVSAIFSPIWGRLADR-YGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTpKE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 131 RQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLsLFPKEKKKKLRigdtvRKLDLPGMFLF 210
Cdd:cd17391 121 KSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTL-FFVKEDFKPVE-----KKKMVSTKEVW 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 211 TvcivlllsfllslsdGIQYVQGILCLVSAGAFIWWEYQVDEPFIQIrmfrqekrlslvYVQFI---ILNIFFyclffgl 287
Cdd:cd17391 195 N---------------SVPNPSLLISLFVTTFIIQLANQSIEPILTL------------YIRQLmgdASNLAF------- 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 288 psyfqdelgwrveMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHpvlasaVLMLAGASAMTFFFIPAPF---WGKGLVLA 364
Cdd:cd17391 241 -------------ISGLVFSATGVSSLLSAPRLGKLGDRIGHHR------ILLGALLASALLYIPQAFVqtpWQLGILRF 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 639685059 365 LLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSilssaVLGMLFGEEIAG 422
Cdd:cd17391 302 LLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGN-----VAGPLLGSAIAA 354
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
41-446 |
1.11e-08 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 56.84 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 41 GLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRrTLFLFGLVLVAVSAIC------APFAPTFAVL-IVIRLLQAIGS 113
Cdd:cd17385 30 GVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAK-FMFVAGMFVSGGCTILfgfldrVPDGTVFIALcFLVRIVEAVGF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 114 SAIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLSLFPK-EKKKK 192
Cdd:cd17385 109 AAFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRyDDDPS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 193 LRIGDTVRKLDLPGMFLFTVCIVLLLSfllslsdGIQYVQGILclvsagafiwweyqvdEPFIqirmfrQEKRLSLVYVq 272
Cdd:cd17385 189 PKSGSMLKLLKIPSVLLLCLSIVSGSV-------SLGFLDPTL----------------SPHL------RQFKLSPGQV- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 273 fiilniffyclffglpsyfqdelgwrvemtGLFMLCMSGMSIMVSPLTGKWVDRGDERHPVLASAVLMlagaSAMTFFFI 352
Cdd:cd17385 239 ------------------------------GLMFLILAGSYAISAPLWGWLSDKKKIPKWLMVIGSII----TGVGFLLL 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 353 -PAPF-------WGKGLVLALLGLSYGIGNV-----ALQAAMLKASPQQM--IGTTSGLFQTCRYLGSILssavlgmlfG 417
Cdd:cd17385 285 gPAPLlpikselWMVIIGLVLLGLSLGAALVptfpeLLNCAREYGFPDNLstYGLVSGLFNAAFSLGAFI---------G 355
|
410 420 430
....*....|....*....|....*....|....*
gi 639685059 418 EEIAGSHFEQLGW---TLIMISL---VGISVSLYF 446
Cdd:cd17385 356 PTLGGFLLERLGFewaATIQAGLafvVGILMSIYY 390
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-180 |
1.78e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 56.28 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 1 MIKWKNNRKVFLTAIAFGTMLNPLNSSMISLALHQIQHeFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFL 80
Cdd:cd06174 196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL-GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 81 FGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLI-RDHVKERQASALAVLSIFASAMTALGPTLGGFLMT 159
Cdd:cd06174 275 IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIaELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
|
170 180
....*....|....*....|..
gi 639685059 160 I-GSWPAIFLVNLPFILISFFL 180
Cdd:cd06174 355 AtFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-444 |
4.92e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.53 E-value: 4.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 12 LTAIAFGTMLNPLNSSMISLALHQIQHEF--GLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVS 89
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRI-GRKKALILTLLLFGLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 90 AICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGS----WP 164
Cdd:cd17316 80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFApSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 165 AIFLVNLPFILISFFLglslfpkekkkklrigdtvrkldlpgmflftvcivlllsfllslsdgiqyvqgilclvsagafi 244
Cdd:cd17316 160 ILFLIGALPALLALLL---------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 245 wweyqvdepfiqirmfrqEKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWV 324
Cdd:cd17316 176 ------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLS 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 325 DRgDERHPVLASAVLMLAGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLG 404
Cdd:cd17316 238 DR-IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 639685059 405 SILSSAVLGMLFgeeIAGSHFEQLGWTLIMISLVGISVSL 444
Cdd:cd17316 317 GGGAPPLIALLL---ASTGGTGVPALILALLAIVALIVAL 353
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-415 |
8.42e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 53.92 E-value: 8.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 30 SLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQ 109
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDR-SNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALN 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 110 AIGSSAIYPSGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTI-GSWPAIFLV-NLPFILISFFLGLSLFP 186
Cdd:TIGR00881 94 GIFQGMGWPPCGRTVTKWFSRSErGTWVSFWNCSHNVGGGLLPPLVLFGIAElYSWHWVFIVpGIIAIIVSLICFLLLRD 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 187 KEKKKKLRIGDTVRKLDLPGMFlftvcivlllsflLSLSDGIQYVQGILCLVSAGAFIWWeyqvdepfiqirmfrqekrL 266
Cdd:TIGR00881 174 SPQSCGLPPAEEMPNEEPDGDA-------------EKKEEELTKKQIFLQYVLLNKVLWY-------------------I 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 267 SLVYVqfiilniFFYCLFFG----LPSYFQDELGWRVEMTGLFMLcMSGMSIMVSPLTGKWVDRGDERHPVLASAVLMLA 342
Cdd:TIGR00881 222 SLGYV-------FVYVVRTGildwSPLYLTQEKGFSKEKASWAFT-LYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMA 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639685059 343 G--ASAMTFFFIPA--PFWGKGLVLALLGLSYGIGNVALQAAMlKASPQQMIGTTSGLFQTCRYLGSILSSAVLGML 415
Cdd:TIGR00881 294 LiiVSLLVYWLNPAanPLMDLICLFALGFLVYGPQMLIGVIAS-ELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
39-185 |
9.03e-08 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 9.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 39 EFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYP 118
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639685059 119 SGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTIGSWPAiflvnLPFILISFFLGLSLF 185
Cdd:cd17477 297 LALALAGDRLPGDElVAANAALLLLYGLGSVIGPLLAGALMDAFGPHG-----LFLFLAAVALLFLLF 359
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
54-445 |
9.26e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 53.76 E-value: 9.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 54 FYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQaiGSSAIYPSGVGLIRDHVKER-- 131
Cdd:cd17472 41 YGLTQAIFQIPFGLLSDRI-GRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ--GSGAISSVVMALLADLTREEnr 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 132 -QASALAVLSIFASAM--TALGPTLGGFLmtigSWPAIFLVNLPFILISFFLGLSLFPKEKKKKLrIGDTVRKldlpgmf 208
Cdd:cd17472 118 tKAMALIGASIGIAFAisMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLFFVPDPPKIVQ-ISEKEKK------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 209 lftvcivlllsfllslsdgiqyvqgilclvsagafiwweyqvdepfiQIRMFRQEKRLSLVYVQFIILNIFFYCLFFGLP 288
Cdd:cd17472 186 -----------------------------------------------KLKKLLKNKRLLRLDFSIFILHFVLMAFFYILP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 289 SYFQDELGWRVEMTGLFMLCMSGMSIMVSPLtGKWVDRGDERHPVLASAVLMLAgASAMTFFFIPAPFWGKGLVLALLGL 368
Cdd:cd17472 219 LLLTQLGGGKGQLWKVYLPAILIGFILMVPF-VIYAEKKGKMKQVFVSSILLIA-VGFLLLLFAATSLWLLIIGLIIFFI 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639685059 369 SYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLGMLFGEEIAGSHFeqLGWTLIMISLVGISVSLY 445
Cdd:cd17472 297 GFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVF--LTILILALLWLLVSFLLP 371
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
10-202 |
9.38e-08 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 54.13 E-value: 9.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 10 VFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmsRRTLFL-FGLVLVAV 88
Cdd:pfam03137 1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKG--HRPRWIgVGALLMGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 89 SAICapFA-PTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALavLSIFAsAMTALGPTLG---GFLMT----- 159
Cdd:pfam03137 79 GSLL--FAlPHFLSFFLGQLLLGIGGTPIYTLGISYIDDNVKKKNSPLY--LGILY-AVRVLGPALGfllGSLCLriyvd 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 639685059 160 ---------------IGSWPAIFLVnLPFILISFFLGLSLFPKEKKKKLRIGDTVRKL 202
Cdd:pfam03137 154 igkvsitltpkdprwVGAWWLGFLI-AGLLLLLTAIPFFFFPKSLPGAAKRRAKKKKE 210
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
16-169 |
1.21e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 53.33 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 16 AFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLfLFGLVLVAVSAICAPF 95
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVL-LLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 639685059 96 AP--TFAVLIVIRLLQAIGSSAIYPSGVGLI--RDHVKERqASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLV 169
Cdd:cd17380 84 LAysSLPLLILSRILLGLGEGVHFPSMTSLFsrWVPVSER-SRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-444 |
1.86e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 53.00 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 11 FLTAIAFGTMLnplnsSMISLALHQiqhEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSA 90
Cdd:cd17329 9 FLNRLGFFMVW-----PFMAIYLHQ---QLGLSASIVGLVLALSAVAGIVASLIGGRLADRF-GRKPVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 91 ICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVK-ERQASALAVLSIFASAMTALGPTLGGFLMTIGSwPAIFLV 169
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTpENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 170 NLPFILISFFLGLSLFPKEKKKKLRIGDTVRKLDLPGMFLFtvcivlllsfllslsdgiqyvqGILCLVSAGAFIWWeyq 249
Cdd:cd17329 159 AAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRD----------------------RAFLLFLLASFLIS--- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 250 vdepfiqirmfrqekrlsLVYVQFiilniffyclFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDE 329
Cdd:cd17329 214 ------------------LIYFQL----------ESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRL 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 330 RHPVLASAVLMLAGASAMTFFFIPAPFwgkGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSS 409
Cdd:cd17329 266 RKILMIGILLFAIGFAVLAFANTLAVL---ILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGP 342
|
410 420 430
....*....|....*....|....*....|....*
gi 639685059 410 AVLGMLFgeeiagsHFEQLGWTLIMISLVGISVSL 444
Cdd:cd17329 343 LVGGLLL-------DLLGPGLPWLILAALGLIAAA 370
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-192 |
2.34e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.58 E-value: 2.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 36 IQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSA 115
Cdd:COG2223 232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG 311
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639685059 116 IYPSGVGLIRDHVKERQASALA--VLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGLSLFPKEKKKK 192
Cdd:COG2223 312 GNGAVFALVPDIFPTKNAGAVYglVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-200 |
3.71e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 52.22 E-value: 3.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 20 MLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAPFAPTF 99
Cdd:PRK11102 1 MLMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSF-GRKPVILGGTLVFALAAVACALAQTI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 100 AVLIVIRLLQaiGSSAIYPSGV--GLIRD-HVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLV-----NL 171
Cdd:PRK11102 80 DQLIYMRFLH--GLAAAAASVVinALMRDmFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVlalaaIL 157
|
170 180
....*....|....*....|....*....
gi 639685059 172 PFILISFFLGLSLfPKEKKKKLRIGDTVR 200
Cdd:PRK11102 158 AAALVFFFIPETL-PKERRQPFHLRTTIR 185
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
12-194 |
5.61e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.47 E-value: 5.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 12 LTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAI 91
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRY-NRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 92 CAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRD-HVKERQASALAVLSIFASAMTALGPTLGGFL-MTIGSWPAIFLV 169
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADlFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRV 159
|
170 180
....*....|....*....|....*
gi 639685059 170 NLPFILISFFLgLSLFPKEKKKKLR 194
Cdd:cd17328 160 TGVLGVLLAIL-LLLFVREPPRGAA 183
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
9-178 |
7.31e-07 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 51.09 E-value: 7.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 9 KVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvmSRRTLFL-FGLVLVA 87
Cdd:cd17336 2 KVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGR--GHRPRWIgIGSILMG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 88 VSAICApFAPTFavLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALavLSIFAsAMTALGPTLgGFLMtiGSWPAIF 167
Cdd:cd17336 80 LGCFLL-ALPHF--LFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLY--IGILY-AMRVLGPAL-GFLL--GSFLLRI 150
|
170
....*....|.
gi 639685059 168 LVNLPFILISF 178
Cdd:cd17336 151 YVDFSRVPLGI 161
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
1-180 |
1.71e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 1 MIKWKNNRKVFLTAIAFGTMLNPLNSSMISLALHqIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFL 80
Cdd:cd17471 192 LVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLY-VTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKR-FGKRRLLL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 81 FGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAvlsIFASAMTA---LGPTLGGFL 157
Cdd:cd17471 270 AGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQPGLATT---LYSNASRIgslLGGLLAGVI 346
|
170 180
....*....|....*....|...
gi 639685059 158 MTIGSWPAIFLVNLPFILISFFL 180
Cdd:cd17471 347 AQYFGYRAVFLVCAVLALLALVL 369
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-438 |
1.41e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.23 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 36 IQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLfGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSA 115
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAV-GLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 116 IYPSGVGLIrdhvkerqasalavlsifasaMTALGPTLGGFLMTIgswpaiflvnlpfilisfflglslfpkeKKKKLRI 195
Cdd:cd17475 101 VQPGGGRAI---------------------MRWFPPRERGLAMGI----------------------------RQTGVPL 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 196 GDTVRKLDLPGMFL---FTVCIVlllsfllslsdgiqyVQGILCLVSAGAFIWW--EYQV--------DEPFIQIRMFRQ 262
Cdd:cd17475 132 GGALAAALLPPLALhygWRAAFV---------------VAGLVSILAAVLFWLFyrEPPAasaatesaSTLLRSLKEVLR 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 263 EKRLSLVYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDR--GDERHPVLASAVLM 340
Cdd:cd17475 197 NRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAI 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 341 LAGASAMTFFFIPA-PFWGKGLVLALLGLSyGIGNVALQAAMLKAS-PQQMIGTTSGLFQTCRYLGSILSSAVLGMLfge 418
Cdd:cd17475 277 AAAALLVLSLLSPGtPLWLLVLLLILLGLF-AIGWNGLYLTLVAESaGPEQAGTALGLANTINFIGIAIGPPLFGLL--- 352
|
410 420
....*....|....*....|
gi 639685059 419 eIAGSHFEQLGWTLIMISLV 438
Cdd:cd17475 353 -VDATHSYAPAWLALALLLV 371
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
2-180 |
1.80e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 2 IKWKNNRKVFLTAIAFGTMLNPLNSSMISLALHQiqHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLF 81
Cdd:cd17370 193 TSLKKLPKAFWLYLLAVALFALGNFSFAFLILRA--QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRI-GRKKLLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 82 GLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTI 160
Cdd:cd17370 270 GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVpAELRGTAYGLFNTVVGIGWLLASLIAGYLWDL 349
|
170 180
....*....|....*....|
gi 639685059 161 GSWPAIFLVNLPFILISFFL 180
Cdd:cd17370 350 ISPSAAFLFSAVLALIALLL 369
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
47-180 |
1.94e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.42 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 47 VSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRD 126
Cdd:cd17317 27 VALVQTIFFLGVLIGSLLFGYLADRF-GRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 127 HV--KERQASALAVLSIFASAMTAlgptLGGFLMTIGSWP----AIFLVNLPFILISFFL 180
Cdd:cd17317 106 IVgpKYRSFVGILFGLFWALGYML----LALLAYLIRDWRwlqlAISLPGLLFLLLLWWL 161
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
235-415 |
2.81e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.00 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 235 LCLVSAGAFIWWEYQVDEPFIQIRMFRQEKRLSLVYVQFIILNIFFYC--LFFGLPSYFQDELGWRVEMTGLFMLCMSGM 312
Cdd:cd17370 167 LLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALgnFSFAFLILRAQELGLSAALIPLLYALFNLV 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 313 SIMVSPLTGKWVDRGDERhpVLASAVLMLAGASAMTFFFIPaPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGT 392
Cdd:cd17370 247 YALAAYPAGRLSDRIGRK--KLLILGYLSLALAYLGFALGS-SLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGT 323
|
170 180
....*....|....*....|...
gi 639685059 393 TSGLFQTCRYLGSILSSAVLGML 415
Cdd:cd17370 324 AYGLFNTVVGIGWLLASLIAGYL 346
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
7-182 |
4.60e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 4.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 7 NRKVFLTAIAFGTMLNPLNSSMISLALHQIQHefGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRR-TLFLFGLVL 85
Cdd:cd17352 182 DPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL--GIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRlYLYIFTLLI 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 86 VAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVK-ERQASALAVLSIFASAMTALGPTLGGFLMTI-GSW 163
Cdd:cd17352 260 LGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGlEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYtGDY 339
|
170
....*....|....*....
gi 639685059 164 PAIFLVNLPFILISFFLGL 182
Cdd:cd17352 340 DAAFYFCGACLLLSGVLLF 358
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-169 |
4.93e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.34 E-value: 4.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 36 IQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLfLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSA 115
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVM-LLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAG 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 639685059 116 I--YPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLV 169
Cdd:cd17355 108 TlaAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-186 |
5.35e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.24 E-value: 5.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 10 VFLTAIAFGtMLNPLnssmISLALHQIqhefGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTlFLFGLVLVAVS 89
Cdd:cd17477 5 VALLGLGSG-LLLPL----LSLRLERE----GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRA-FAAGAAITAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 90 AICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGswpaifl 168
Cdd:cd17477 75 VLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAtNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG------- 147
|
170
....*....|....*...
gi 639685059 169 vNLPFILISFFLGLSLFP 186
Cdd:cd17477 148 -ALPFLIAAVLLLLALVP 164
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
35-182 |
5.60e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 5.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 35 QIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSS 114
Cdd:cd17490 220 LIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTG 299
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 115 AIYPSGVGL-IRDHVKERQASALAVL-SIFASAMTaLGPTLGGFLMTIGSWPAIFLVNLPFILISFFLGL 182
Cdd:cd17490 300 ILFPLLMSLsIEGVPAEQRSTAMGFFqAIYALGMF-LGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
290-445 |
6.48e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 6.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 290 YFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHPVLASAVLMLAGASAMTFFFIPAPFWgkgLVLALLGLS 369
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA---IALVLTGFG 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 639685059 370 YGIGNVALQAAMLKASPqqmiGTTSGLFQTCRYLGSILsSAVLGMLFGEEIAGSHFEQLGWTLIMISLVGISVSLY 445
Cdd:cd17329 102 GGLFEPASEAMIADVTT----PENRTRAFSLLYWAINL-GVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLF 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-161 |
8.33e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 8.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 8 RKVFLTAIAFGTMLNplnsSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVA 87
Cdd:COG2211 231 LLLLLAYLLFFLALA----LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR-FGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 88 VSAICAPFAP--TFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV--------KERQASALAVLSIFASAMTALGPTLGGFL 157
Cdd:COG2211 306 LGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktgRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
....
gi 639685059 158 MTIG 161
Cdd:COG2211 386 LALF 389
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
11-179 |
1.12e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 11 FLTAIAfgtmlnplnSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQ----PVSGRIGdhvmsRRTLFLFGLVLV 86
Cdd:PRK15402 23 FATYIA---------NDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQwllgPLSDRIG-----RRPVMLAGVAFF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 87 AVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKErqASALAVLSIFAS-AMTA--LGPTLGGFLMTIGSW 163
Cdd:PRK15402 89 ILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEE--ADAIKITALMANvALLAplLGPLVGAALIHVLPW 166
|
170
....*....|....*.
gi 639685059 164 PAIFLVNLPFILISFF 179
Cdd:PRK15402 167 RGMFVLFAALAALSFF 182
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
32-192 |
1.33e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 44.13 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 32 ALHQIQHEFGLSFTTVSWLISTFYLASAVTQ----PVSGRIGdhvmsRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRL 107
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQlfygPLSDRVG-----RRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 108 LQAIGssaiypSGVG------LIRDHVKE---RQASALAVLSIFASAMTAlgPTLGGFLMTIGSWPAIFLVNLPF-ILIS 177
Cdd:PRK11652 105 IQGLG------TGVGgvmartLPRDLYEGtqlRHANSLLNMGILVSPLLA--PLIGGLLTTLFGWRACYLFLLLLgAGVT 176
|
170
....*....|....*...
gi 639685059 178 FFLGLSL---FPKEKKKK 192
Cdd:PRK11652 177 FSMARWMpetRPADARRT 194
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
16-118 |
1.83e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 43.71 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 16 AFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGlVLVAVSAICAPF 95
Cdd:cd17359 7 ALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISA-VLFFISALGSAF 85
|
90 100
....*....|....*....|....*.
gi 639685059 96 APTFAVLIVIRLLQAIG---SSAIYP 118
Cdd:cd17359 86 SPNFTIFIIARIIGGLAvggASALVP 111
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
28-180 |
2.02e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.53 E-value: 2.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 28 MISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRL 107
Cdd:PRK03893 38 LITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDR-YGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARL 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639685059 108 LQAIGSSAIYPSGVGLIRD--HVKERQASALAVLSIFaSAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFL 180
Cdd:PRK03893 117 VIGMGMAGEYGSSATYVIEswPKHLRNKASGFLISGF-SIGAVVAAQVYSLVVPVWGWRALFFIGILPIIFALWL 190
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
38-181 |
2.24e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 43.34 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 38 HEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDhVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIY 117
Cdd:cd17365 27 QDWGLSPAQLGPVGSAALFGMAIGALLAGPLAD-RFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAM 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 639685059 118 PSGVGLIRDHVKERQAS-ALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVN--LPFILISFFLG 181
Cdd:cd17365 106 PNAITLVSEYAPARRRSlAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGgvPPLILLPLLRG 172
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
36-182 |
2.65e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 36 IQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVM--SRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGS 113
Cdd:cd17319 206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGI 285
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639685059 114 SAIYPSGVGLIRDHVKERQ-ASALAVLSIFASAMTALGPTLGGFLMTI-GSWPAIFLVNLPFILISFFLGL 182
Cdd:cd17319 286 GAASPVFWSLPADLLPGEAaATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-151 |
2.70e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 1 MIKWKNNRKVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFL 80
Cdd:pfam07690 191 IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 639685059 81 FGLVLVAVSAICAPFAPTF--AVLIVIRLLQAIGSSAIYPSGVGLIRDHV-KERQASALAVLSIFASAMTALGP 151
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLssLWLLLALLLLGFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGALGP 344
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
9-179 |
3.40e-04 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 42.77 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 9 KVFLTAIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAV 88
Cdd:PRK10091 2 KKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSR-YSLKHILLFLVALCVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 89 SAICAPFAPTFAVLIVIRLLQAIGSSAIYpsGVGLIRDHVKERQASALAVLSIFASAMTA---LGPTLGGFLMTIGSWPA 165
Cdd:PRK10091 81 GNAMFTLSSSYLMLAIGRLVSGFPHGAFF--GVGAIVLSKIIKPGKVTAAVAGMVSGMTVanlLGIPLGTYLSQEFSWRY 158
|
170
....*....|....
gi 639685059 166 IFLVNLPFILISFF 179
Cdd:PRK10091 159 TFLLIAVFNIAVLA 172
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-191 |
3.65e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.69 E-value: 3.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 35 QIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLfGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSS 114
Cdd:cd17333 21 SLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLIL-GLLLISLALALIFATPSIYLFVVLMFLAGLGAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 115 AIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIG---SWPAIFLVNLPFILISFFLGLSLFPKEKKK 191
Cdd:cd17333 100 ILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSElswSWAYLIIGLIYLLLAILILLTLFPELPSAR 179
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
14-112 |
4.31e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.56 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 14 AIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTV--SWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAI 91
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSlqGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100
....*....|....*....|.
gi 639685059 92 CApFAPTFAVLIVIRLLQAIG 112
Cdd:cd17315 81 SA-LAPNVWVLIVGRFLLGLG 100
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
269-442 |
4.58e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 269 VYVQFIILNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDRGDERHPVLASAVLMLAGASAMT 348
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 349 FFfipAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLGMLfgeeiagshFEQL 428
Cdd:pfam07690 81 FA---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL---------ASLF 148
|
170
....*....|....
gi 639685059 429 GWTLIMISLVGISV 442
Cdd:pfam07690 149 GWRAAFLILAILSL 162
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
32-212 |
4.75e-04 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 42.73 E-value: 4.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 32 ALHQIQHEFGLSFTtvSWLISTFY-LASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQ- 109
Cdd:pfam06609 66 ALPNILQDIGQSEN--QGLFSTLWtMGQAVSILMMGRLTDR-FGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLg 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 110 -AIGSSAIYPSGVGLIRDHvkERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLV-----NLPFILISFFLGLS 183
Cdd:pfam06609 143 vAAGPAGASPLFIGELMSN--KTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIyiimsAIAVLLIIIWYHPP 220
|
170 180
....*....|....*....|....*....
gi 639685059 184 LFPKEKKKKLRIGDTVRKLDLPGMFLFTV 212
Cdd:pfam06609 221 SFAQLHGKKARKRDELAKLDWIGIFLVIA 249
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
39-180 |
5.18e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 5.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 39 EFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYP 118
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFP 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639685059 119 SGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLVNLPFILISFFL 180
Cdd:cd17330 284 ALSALLSKSVpSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
10-192 |
5.25e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 5.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 10 VFLTAIAFGtMLNPLNSSMISLALHQIQHEFGLSFTTVSwlistfyLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVS 89
Cdd:cd17471 5 TLLTGLAGA-FVLPYLSLFLTEELGASPLQIGIFMTLSA-------LSGIVVSQWLGRLSDRGGDRKPLILLALLAGALG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 90 AICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVK----ERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPA 165
Cdd:cd17471 77 YLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADrssgRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTG 156
|
170 180
....*....|....*....|....*..
gi 639685059 166 IFLVNLPFILISFFLGLSLFPKEKKKK 192
Cdd:cd17471 157 LFLLAALLYLVVALLVLFLLPSVKPPA 183
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
50-184 |
7.03e-04 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 41.61 E-value: 7.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 50 LISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGL-VLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHV 128
Cdd:cd17423 245 VVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWtALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELV 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 639685059 129 K-ERQASALAVLSIFASAMTALGPTLGGFLMTI-GSWPAIFLVNLPFILISFFLGLSL 184
Cdd:cd17423 325 GvERVLNATGLLQMIESVGGLLGPPLSGWLRDItGDYTASFLVAGSFLLLGSLILLTL 382
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-184 |
7.23e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.90 E-value: 7.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 14 AIAFGTMLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLfLFGLVLVAVSAICA 93
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVL-VITILLFAVFTLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 94 PFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQ--------ASALAVLSIFASAMTALgptLGGFLMTIGSWPA 165
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHrgkalgyvQSGWAVGWLLATLLAAL---LFPLLPPEIAWRV 158
|
170
....*....|....*....
gi 639685059 166 IFLVNLPFILISFFLGLSL 184
Cdd:cd17371 159 LFLLGALPALLVLFIRRFV 177
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
44-161 |
8.28e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 41.72 E-value: 8.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 44 FTTVSWLI--STFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAICAPFAPT-----FAVLIVIRLLQAIGSSAI 116
Cdd:cd17337 241 FSTSQWLQiwGIIFLVNIFFNLIFGILGDKIGWRRTVRWFGGVGCAISTLLFYYVPQlfghnYWAALIAAILFGIGLAGF 320
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 639685059 117 YPSGvGLIRDHVKERQASALAVLSIFASAMTALGPTLGG-FLMTIG 161
Cdd:cd17337 321 VPLS-ALMPSLAPEHKGAAMSILNLGAGLSNFVGPAIVTlFLGSFG 365
|
|
| MFS_SLCO5_OATP5 |
cd17404 |
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ... |
9-186 |
1.12e-03 |
|
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340962 [Multi-domain] Cd Length: 425 Bit Score: 41.18 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 9 KVFLTAIAFGTMLNPLNSS-MISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHvmSRRTLFL-FGLVLV 86
Cdd:cd17404 1 KAFLVCMCLLIFIQSALSSgYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGR--GHRPRWIaVGGVLI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 87 AV-SAICApfAPTFavLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVlsiFASAMTALGPT----LGGFLMTIG 161
Cdd:cd17404 79 ALgSFLFS--LPHF--FILAQILIGMGGTPIFTLGTTYLDDHVKKESSSLYLA---IMYVMGALGPAagflLGGLLINFY 151
|
170 180 190
....*....|....*....|....*....|....*...
gi 639685059 162 SWPAIFLVNLP-------------FILISFFLGLSLFP 186
Cdd:cd17404 152 VDPLSTPPDISpgdprwigawwggFLLCGIALLLVAFP 189
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
40-185 |
1.47e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.64 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 40 FGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLfLFGLVLVAVS-AICAPFAPTFAVLIVIRLLQAIGSSAIYP 118
Cdd:cd17504 212 FGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL-LIGLVISAVGlLLLALLHSSLWALVVALLLIGIGLGLAFA 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 639685059 119 SGVGLIRDHV-KERQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIFLV-------NLPFILISFFLGLSLF 185
Cdd:cd17504 291 SLPNIVVESVpPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGvptegayVLAFLIGAALALAALL 365
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
35-180 |
1.48e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.77 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 35 QIQHEFGLSfTTVSWL----ISTFYLASAVTQPVSGRIGDHvMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQA 110
Cdd:TIGR00898 114 TIVTEWDLV-CEDAWKvdltQSCFFVGVLLGSFVFGYLSDR-FGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVG 191
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 639685059 111 IGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAMTALGptLGGFLMTIGSWPAIFLV----NLPFILISFFL 180
Cdd:TIGR00898 192 MGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVL--LPLVAYFIPDWRWLQLAvslpTFLFFLLSWFV 263
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
316-422 |
1.49e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.91 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 316 VSPLTGKWVDRGDERHPVLASAVLMLAGASAMTFFFIPAPFWGKGLVLALLGLSYGIGNVALQAAMLKASPQQMIGTTSG 395
Cdd:COG2270 68 LAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLGLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGRVSG 147
|
90 100
....*....|....*....|....*...
gi 639685059 396 LFQTCRYLGSILSSAV-LGMLFGEEIAG 422
Cdd:COG2270 148 LGWALGYLGGVLLLLInLALFLKPEAFG 175
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
20-167 |
2.56e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 40.00 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 20 MLNPLNSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVmSRRTLFLFGLVLVAVSAICAPFAPTF 99
Cdd:PRK10473 13 LLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRS-GRKPVAIPGAALFIIASLLCSLAETS 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639685059 100 AVLIVIRLLQAIGSSAIYPSGVGLIRDHVKE-RQASALAVLSIFASAMTALGPTLGGFLMTIGSWPAIF 167
Cdd:PRK10473 92 SLFLAGRFLQGIGAGCCYVVAFAILRDTLDDrRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
39-189 |
3.50e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 39 EFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYp 118
Cdd:cd17371 239 ERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPF- 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639685059 119 SGVG--LIRDHVKERQASALAVLSIFASAMTALGPTLGGFLMTIGSWpAIFLVNLPFILISFFLGLSLFPKEK 189
Cdd:cd17371 318 SGMGayLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSL-GTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
25-167 |
6.76e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 25 NSSMISLALHQIQHEFGLSFTTVSWLISTFYLASAVTQPVSGRIGDHVMSRRTLFlfglVLVAVSAICAPFAPTFA---- 100
Cdd:cd17318 36 NTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLG----YSILITALLTLLTPLAArggy 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639685059 101 -VLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASAM-TALGPTLGGFLMTIGSWPAIF 167
Cdd:cd17318 112 gALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFgTVIAMPLSGFLCESLGWPSIF 180
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
275-446 |
7.42e-03 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 38.41 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 275 ILNIFFYCLFFGL----PSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDR-GDERHPVLASAVLMLAGASAMTF 349
Cdd:cd17340 224 IICVFYYVAVFPFiglgTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKvGRNILWVLIALVITLLGHLLLAF 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 350 FFIPaPFWGkglvLALLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLGMLFGEEIAGShFEQLG 429
Cdd:cd17340 304 TFVN-PLIA----MVIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLL-LEVFF 377
|
170
....*....|....*..
gi 639685059 430 WTLIMISLVgISVSLYF 446
Cdd:cd17340 378 IACLCVSLI-ALIILYL 393
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
58-413 |
7.85e-03 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 38.44 E-value: 7.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 58 SAVTQPVSGRIGDhVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSaiypsGVGLIR-------DHVKE 130
Cdd:cd17322 50 SAVSQPPYAKLSD-VFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYT-----GLNLLLtliladfSSLKN 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 131 RqASALAVLSIFASAMTALGPTL-GGFLMT------IGSWPAIF-LVNLPFILISFFL-----------GLSLFPKEKKK 191
Cdd:cd17322 124 R-GFASAIPSLPYIITTWIGGNIaQAALPNsnwrwgYGMWAIILpLSSLPLVLCLLYMqrkarkdgeikELKNQETEEQT 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 192 KLRIGDTVR---KLDLPGMFLFTV---CIVLLLSFLLSLSDG-------IQYVQGILCLVsagAFIWWEYQV-DEPFIQI 257
Cdd:cd17322 203 GGLSQNLVKlfwKLDIFGVILLTAglgLILVPLTLAGGAKSKwknssiiAMIVLGGVLLV---AFLLWEAKFaKYPFLPF 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 258 RMFRQEKRLSLVYVQFIIlNIFFYCLFFGLPSYFQDELGWRVEMTGLFMLCMSGMSIMVSPLTGKWVDR-GDERHPVLAS 336
Cdd:cd17322 280 RLLKDRTILAACLIDFFY-FFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKtRRYKVLVIIG 358
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 639685059 337 AVLMLAGASAMTFFFIPAPFWGkGLVLA--LLGLSYGIGNVALQAAMLKASPQQMIGTTSGLFQTCRYLGSILSSAVLG 413
Cdd:cd17322 359 VPLYIVGMGLLIRYRGGSGSHG-GIIGAliLIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISG 436
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
66-190 |
9.02e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 9.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639685059 66 GRIGDHVMSRRTLFLFGLVLVAVSAICAPFAPTFAVLIVIRLLQAIGSSAIYPSGVGLIRDHVKERQASALAVLSIFASA 145
Cdd:cd17490 52 GILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNL 131
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 639685059 146 MTALGPTLGGFLMTIGSWPAIFLVNLPFILISFflGLSLFPKEKK 190
Cdd:cd17490 132 GQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGF--ILSLFIKEER 174
|
|
| |
