|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
2-454 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 593.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 2 IKRTVKQVAQMAGGTLSNEAfgEEQIHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWnqtEANPPFGV 81
Cdd:COG0770 1 ILLTLAEIAEATGGRLIGDP--DLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALV---SRPLPADL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 82 PVILVEDTLTALQQLAKSYLKEENPRVVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNFNNHIGLPLTILAMPEGTEIA 161
Cdd:COG0770 76 PLIVVDDTLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 162 VLEMGMSAKGEIEFLSKLAEPDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARSV 241
Cdd:COG0770 156 VLEMGMNHPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAKARV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 242 KTFGESEDCDIKVIHIHQLAEGTEFQVEGYAQG--FLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRL 319
Cdd:COG0770 236 LTFGLSEDADVRAEDIELDEDGTRFTLHTPGGEleVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 320 ELFKTDKGITVINDAYNASPTSMKAAIDLVGDMDGFANRILVLGDMLEMGSEEETYHFEVGEYIKPEFIDHVLTFGRLGA 399
Cdd:COG0770 316 EVIEGAGGVTLIDDSYNANPDSMKAALDVLAQLPGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELAR 395
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 639691732 400 FIAEgakkAFGDDRVSSYMDKEELKKKLADVAGPDDVVLVKASRGMRLEDVITAL 454
Cdd:COG0770 396 AIAE----AAGGERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEAL 446
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
32-454 |
7.85e-160 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 457.88 E-value: 7.85e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 32 TDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWNQtEANPPFGVPVILVEDTLTALQQLAKSYLKEENPRVVGI 111
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDR-EVGPDNGLPQILVDDTLEALQALARAKRAKFSGKVIGI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 112 TGSNGKTTTKDMIHSVLQTTYRVHKTDGNFNNHIGLPLTILAMPEGTEIAVLEMGMSAKGEIEFLSKLAEPDAAVITNIG 191
Cdd:TIGR01143 80 TGSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 192 ESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQ-RANALARSVKTFG-ESEDCDIKVIHIHQLA-EGTEFQV 268
Cdd:TIGR01143 160 PAHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADlAKRLPNRNILSFGfEGGDFVAKDISYSALGsTSFTLVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 269 EGYAQGFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRLELFkTDKGITVINDAYNASPTSMKAAIDL 348
Cdd:TIGR01143 240 PGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFEVQ-TKNGLTLIDDTYNANPDSMRAALDA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 349 VGDMDGfaNRILVLGDMLEMGSEEETYHFEVGEYIKPEFIDHVLTFGRLGAFIAEGAKKafgddRVSSYMDKEELKKKLA 428
Cdd:TIGR01143 319 LARFPG--KKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGK-----QGKHFADKDELLAFLK 391
|
410 420
....*....|....*....|....*.
gi 639691732 429 DVAGPDDVVLVKASRGMRLEDVITAL 454
Cdd:TIGR01143 392 TLVRKGDVVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
13-454 |
4.24e-118 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 367.88 E-value: 4.24e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 13 AGGTLSNEAFGEEQIHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWNQteANPPFGVPVILVEDTLTA 92
Cdd:PRK11929 512 KGGSNSLQINSLPHAGAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVER--QVADVDLPQIVVDDTRAA 589
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 93 LQQLAKSYLKEENPRVVGITGSNGKTTTKDMIHSVL---QTTYRVHKTDGNFNNHIGLPLTILAMPEGTEIAVLEMGMSA 169
Cdd:PRK11929 590 LGRLATAWRARFSLPVVAITGSNGKTTTKEMIAAILaawQGEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNH 669
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 170 KGEIEFLSKLAEPDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRAN-ALARSVKTFGESE 248
Cdd:PRK11929 670 PGEIAYLAAIAAPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKlAGARRVLRFGLQP 749
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 249 ------DCDIKVIHIHQlAEGTEFQV---EGYAQgFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRL 319
Cdd:PRK11929 750 gadvyaEKIAKDISVGE-AGGTRCQVvtpAGSAE-VYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRM 827
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 320 ELFKTDKGITVINDAYNASPTSMKAAIDLVGDMDGfANRILVLGDMLEMGSEEETYHFEVGEYIKPEFIDHVLTFGRLGA 399
Cdd:PRK11929 828 QRRRLSCGTRIIDDTYNANPDSMRAAIDVLAELPN-GPRALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAAR 906
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 639691732 400 FIAegakKAFGDDRVSSYMDKEELKKKLADVAGPDDVVLVKASRGMRLEDVITAL 454
Cdd:PRK11929 907 DAA----AAFGAGARGVCASVDEIIAALRGALPEGDSVLIKGSRFMRLERVVDAL 957
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
1-454 |
5.97e-94 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 291.16 E-value: 5.97e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 1 MIKRTVKQVAQMAGGTLsneaFGEE-QIHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWNQteaNPPF 79
Cdd:PRK10773 1 MISVTLSQLADILNGEL----QGADiTIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSR---PLDI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 80 GVPVILVEDTLTALQQLAKSYLKEENPRVVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNFNNHIGLPLTILAMPEGTE 159
Cdd:PRK10773 74 DLPQLVVKDTRLAFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 160 IAVLEMGMSAKGEIEFLSKLAEPDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDE-PLLRQRANALA 238
Cdd:PRK10773 154 YAVIELGANHQGEIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSnDWLNWQSVIGS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 239 RSVKTF--GESEDCDIKVIHIHQLAEGTEFQVE---GYAQgFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTK 313
Cdd:PRK10773 234 KTVWRFspNAANSVDFTATNIHVTSHGTEFTLHtptGSVD-VLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 314 LTGMRLELFKTDKGITVINDAYNASPTSMKAAIDLVGDMDGFanRILVLGDMLEMGSEEETYHFEVGEYIKPEFIDHVLT 393
Cdd:PRK10773 313 AVPGRLFPIQLAEGQLLLDDSYNANVGSMTAAAQVLAEMPGY--RVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLS 390
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 639691732 394 FGRLGAFIAEgakkAFGddRVSSYMDKEELKKKLADVAGPDDV--VLVKASRGMRLEDVITAL 454
Cdd:PRK10773 391 VGKLSHAISE----ASG--VGEHFADKTALIARLKALLAEHQVitILVKGSRSAAMEEVVRAL 447
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
5-454 |
1.46e-69 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 228.51 E-value: 1.46e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 5 TVKQVAQMAGGTLSNEAfgEEQIHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAA-AVLWNQTEANPPFGVPV 83
Cdd:PRK14093 8 TSDAMAEAMGATRSGAL--PRDVTGISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAAlAVVERAQRDKFAADAPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 84 ILVEDTLTALQQLAKSYLKEENPRVVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNFNNHIGLPLTILAMPEGTEIAVL 163
Cdd:PRK14093 86 LVVDDVLAALRDLGRAARARLEAKVIAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 164 EMGMSAKGEIEFLSKLAEPDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLL-RQRANALARSVK 242
Cdd:PRK14093 166 EIGMNHAGEIEPLVKMVRPHVAIITTVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFdRLAASARAAGIA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 243 ---TFGESEDCDIKVIHIHQLAEGTEFQVE--GYAQGFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLT-- 315
Cdd:PRK14093 246 rivSFGADEKADARLLDVALHADCSAVHADilGHDVTYKLGMPGRHIAMNSLAVLAAAELAGADLALAALALSQVQPAag 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 316 -GMRLELFKTDKGITVINDAYNASPTSMKAAIDLVGD--MDGFANRILVLGDMLEMGSEEETYHFEVGEYIKPEFIDHVL 392
Cdd:PRK14093 326 rGVRHTLEVGGGEATLIDESYNANPASMAAALGVLGRapVGPQGRRIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVF 405
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 639691732 393 TFG----RLGAFIAEGAKKAFGDDRVSsymdkeeLKKKLADVAGPDDVVLVKASRGMRLEDVITAL 454
Cdd:PRK14093 406 CCGplmrNLWDALSSGKRGGYAEDAAA-------LESQVVAAIRAGDVIMVKGSLGSRMKTIVTAL 464
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
15-454 |
1.18e-65 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 225.22 E-value: 1.18e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 15 GTLSNEAFGEE--QIHGVTTDTRKVS--KGALFIPLIGEHFNGHTFASKAVELGA--AAVLWNQTEANPPFGVPVILVED 88
Cdd:PRK11930 10 GILGAEGLGDKdaIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVrnFVVSEEKHPEESYPDANFLKVKD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 89 TLTALQQLAKSYLKEENPRVVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNFNNHIGLPLTILAMPEGTEIAVLEMGMS 168
Cdd:PRK11930 90 PLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHELGIFEAGIS 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 169 AKGEIEFLSKLAEPDAAVITNIGESHMQDLGSREAIADAKCEITKglKEDGTFYYLGDEPLLRQ--RANALARSVKTFGE 246
Cdd:PRK11930 170 QPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLFK--DCDVIIYNGDNELISSCitKSNLTLKLISWSRK 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 247 SEDCDIKVIHIHQLAEGTEFQVE--GYAQGFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRLELFKT 324
Cdd:PRK11930 248 DPEAPLYIPFVEKKEDHTVISYTykGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEPVAMRLEVKEG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 325 DKGITVINDAYNASPTSMKAAIDLVGDMDGFANRILVLGDMLEMGSEEETYHFEVGEYIKPEFIDHVLTFgrlGAFIAEG 404
Cdd:PRK11930 328 INNCTLINDSYNSDLQSLDIALDFLNRRSQSKKKTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGI---GEEISSE 404
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 639691732 405 AKKaFGDDRVSSYMDKEELKKKLADVAGPDDVVLVKASRGMRLEDVITAL 454
Cdd:PRK11930 405 ASK-FEGTEKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
111-295 |
2.79e-54 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 179.81 E-value: 2.79e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 111 ITGSNGKTTTKDMIHSVLQTTYRVHKTDG--------NFNNHIGLPLTILAMPE-GTEIAVLEMGMSAKGEiEFLSKLAE 181
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGTIGtyigksgnTTNNAIGLPLTLAEMVEaGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 182 PDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARS---VKTFGESEDCDIKVIHIH 258
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLKKAgvrVITYGIEGEADLRAANIE 159
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 639691732 259 QLAEGTEFQVEGYAQGFL---IPVLGKHNVKNALAAIAIG 295
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELeieIPLLGRHNVYNALAAIAAA 199
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
29-347 |
1.24e-45 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 164.48 E-value: 1.24e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 29 GVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWNQTEANPPFGVPVILVEDTLTALQQLAKSYLKE--ENP 106
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGALLAAGVPVIVVPDPRAALALLAAAFYGHpsQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 107 RVVGITGSNGKTTTKDMIHSVLQTTYrvHKTdGNF---NNHIG-----LPLT---------ILAM--PEGTEIAVLEmgM 167
Cdd:COG0769 81 KLIGVTGTNGKTTTTYLLAQILRALG--KKT-GLIgtvGNGIGgelipSSLTtpealdlqrLLAEmvDAGVTHVVME--V 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 168 SAKG-------EIEFlsklaepDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARS 240
Cdd:COG0769 156 SSHAldqgrvdGVRF-------DVAVFTNLTRDHLDYHGTMEAYFAAKARLFDQLGPGGAAVINADDPYGRRLAAAAPAR 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 241 VKTFGESEDCDIKVIHIHQLAEGTEFQVEGYAQGFLI--PVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQtkLTGM- 317
Cdd:COG0769 229 VITYGLKADADLRATDIELSADGTRFTLVTPGGEVEVrlPLIGRFNVYNALAAIAAALALGIDLEEILAALEK--LKGVp 306
|
330 340 350
....*....|....*....|....*....|.
gi 639691732 318 -RLELFKTDKGITVINDaYNASPTSMKAAID 347
Cdd:COG0769 307 gRMERVDGGQGPTVIVD-YAHTPDALENVLE 336
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
105-438 |
4.76e-32 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 126.73 E-value: 4.76e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 105 NPRVVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNfnnhIGLP-LTILAMPEGTEIAVLEMgmsakgeIEFLSKLAePD 183
Cdd:COG0771 104 PAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGN----IGTPlLDLLLEPEPPDVYVLELss---fqLETTPSLR-PD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 184 AAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARSVKTFGESEDCDIKV------IHI 257
Cdd:COG0771 176 VAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLTRALAEEAKARVVPFSLKEPLEGGAgledgkLVD 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 258 HQLAEgTEFQVEGyaqgflIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRLELFKTDKGITVIND--AY 335
Cdd:COG0771 256 RASGE-ELLPVDD------LRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFINDskAT 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 336 NasPTSMKAAIdlvgdmDGFANR-ILVLG------DMLEMGSeeetyhfEVGEYIKpefidHVLTFGRLGAFIAEgakkA 408
Cdd:COG0771 329 N--PDATLAAL------ESFDGPvVLIAGgldkgaDFSPLAP-------AVAERVK-----AVVLIGEDAEKIAA----A 384
|
330 340 350
....*....|....*....|....*....|..
gi 639691732 409 FGDDRVSSYM--DKEELKKKLADVAGPDDVVL 438
Cdd:COG0771 385 LAGAGVPVVIveTMEEAVAAAAELARPGDVVL 416
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
27-345 |
6.01e-32 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 127.05 E-value: 6.01e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 27 IHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWnQTEANPPF-GVPVILVEDTLTALQQLAKSYLKE-- 103
Cdd:TIGR01085 4 VTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVV-ERDVDFYVaPVPVIIVPDLRHALSSLAAAFYGHps 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 104 ENPRVVGITGSNGKTTTKDMIHSVLQTTYR---VHKTDGNF---NNHIGLP--------LTILAMPE-----GTEIAVLE 164
Cdd:TIGR01085 83 KKLKVIGVTGTNGKTTTTSLIAQLLRLLGKktgLIGTIGYRlggNDLIKNPaalttpeaLTLQSTLAemveaGAQYAVME 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 165 M---GMSAK--GEIEFlsklaepDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALAR 239
Cdd:TIGR01085 163 VsshALAQGrvRGVRF-------DAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLPK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 240 S-----VKTFGESEDCDIKVIHIHQLAEGTEFQVEGYAQGFLI--PVLGKHNVKNALAAIAIGQHFG-LNERQIAQGLMQ 311
Cdd:TIGR01085 236 DitvsaITQPADGRAQDIKITDSGYSFEGQQFTFETPAGEGHLhtPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEK 315
|
330 340 350
....*....|....*....|....*....|....
gi 639691732 312 TKLTGMRLELFKTDKGITVINDaYNASPTSMKAA 345
Cdd:TIGR01085 316 FRGVPGRMELVDGGQKFLVIVD-YAHTPDALEKA 348
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
107-439 |
1.19e-30 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 122.87 E-value: 1.19e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 107 RVVGITGSNGKTTTKDMIHSVLQttyrvhktdgnfnnHIGLPLTIL--AMPEGTeiavlemGMSAK-GEIEFLskLAE-- 181
Cdd:COG0773 105 RSIAVAGTHGKTTTTSMLAHILE--------------EAGLDPTFLigGILNNF-------GTNARlGDGDYF--VAEad 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 182 ----------PDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARSVKTFGESEDCD 251
Cdd:COG0773 162 esdgsflhysPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPRCGRPVITYGFSEDAD 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 252 IKVIHIHQLAEGTEFQV--EGYAQG-FLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRLELFKTDKGI 328
Cdd:COG0773 242 YRAENIRIDGGGSTFDVlrRGEELGeVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGV 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 329 TVINDaYNASPTSMKAAID----LVGDmdgfaNRILV---------LGDMLEmgseeetyhfevgeyikpEFI------D 389
Cdd:COG0773 322 TVIDD-YAHHPTEIAATLAaareKYPD-----RRLVAvfqphrysrTRDFLD------------------EFAealslaD 377
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 639691732 390 HVL-----------TFGRLGAFIAEGAKKAFGDdrVSSYMDKEELKKKLADVAGPDDVVLV 439
Cdd:COG0773 378 EVIlldiyaarekpIPGVSSEDLAEAIRKRGKD--VVYVPDLDELVEALAEIARPGDVVLT 436
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
106-438 |
1.66e-29 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 119.37 E-value: 1.66e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 106 PRVVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNfnnhIGLPLTILAMPEGTEIAVLEMgmsAKGEIEFLSKLAePDAA 185
Cdd:TIGR01087 102 LPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGN----IGTPALEVLDQEGAELYVLEL---SSFQLETTESLR-PEIA 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 186 VITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARSVKTFGESEDCDIKvihIHQLAEGTE 265
Cdd:TIGR01087 174 LILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQKSKAQVIWFSVEKDAERG---LCIRDGGLY 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 266 FQVegyaQGFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRLELFKTDKGITVINDAYNASPTSMKAA 345
Cdd:TIGR01087 251 LKP----NDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDSKATNVHATLAA 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 346 IdlvgdmDGFANRI-LVLGDMLemgsEEETYHFEVgEYIKPeFIDHVLTFGRLGAFIAEGAKKAFGDDRVSSYMdkEELK 424
Cdd:TIGR01087 327 L------SAFDNPViLIVGGDD----KGADFSPLA-PAAAG-KVKAVLAIGEDAAKIAPLLKEAGLSVYLVESL--EEAV 392
|
330
....*....|....
gi 639691732 425 KKLADVAGPDDVVL 438
Cdd:TIGR01087 393 QAAREVASPGDVVL 406
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
19-347 |
2.41e-28 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 116.38 E-value: 2.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 19 NEAFGEEQIHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWnQTEANPPFGVPVILVEDTLTALQQLAK 98
Cdd:PRK00139 7 RDLLAPVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVA-EADGEAGTGVPVIIVPDLRKALALLAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 99 SYLKE--ENPRVVGITGSNGKTTTKDMIHSVLQ----------TTYRVhktDGNFNNHIGL----PLTILAM-----PEG 157
Cdd:PRK00139 86 AFYGHpsDKLKLIGVTGTNGKTTTAYLLAQILRllgektaligTLGNG---IGGELIPSGLttpdALDLQRLlaelvDAG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 158 TEIAVLEmgMSAKG-------EIEFlsklaepDAAVITNIGESHMQDLGSREAIADAKceitKGLkedgtFyylgDEPLL 230
Cdd:PRK00139 163 VTYAAME--VSSHAldqgrvdGLKF-------DVAVFTNLSRDHLDYHGTMEDYLAAK----ARL-----F----SELGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 231 RQRANA-------LARSVKTFG-ESEDCDIKVIHIHQLAEGTEFQVEGyaqGFLIPVLGKHNVKNALAAIAIGQHFGLNE 302
Cdd:PRK00139 221 AAVINAddevgrrLLALPDAYAvSMAGADLRATDVEYTDSGQTFTLVT---EVESPLIGRFNVSNLLAALAALLALGVPL 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 639691732 303 RQIAQGLMQtkLTGM--RLELFKTDKGITVIND-AYNasPTSMKAAID 347
Cdd:PRK00139 298 EDALAALAK--LQGVpgRMERVDAGQGPLVIVDyAHT--PDALEKVLE 341
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-361 |
6.89e-25 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 108.25 E-value: 6.89e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 27 IHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLWNQ--TEANPPFGVPVILVEDTLTALQQLAKSYL--K 102
Cdd:PRK11929 29 TADLRLDSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAegEDQVAAADALVLPVADLRKALGELAARWYgrP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 103 EENPRVVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNFNNH-----IGLPLT---------ILA-MPE-GTEIAVLEMG 166
Cdd:PRK11929 109 SEQLSLVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARldgrlIPGSLTtpdaiilhrILArMRAaGADAVAMEAS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 167 mSAKGEIEFLSKLaEPDAAVITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARSVKTFGE 246
Cdd:PRK11929 189 -SHGLEQGRLDGL-RIAVAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLLAALPRGLKVGYS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 247 SEDCDIKViHIHQLAEGTEFQV------EGYAQgFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRLE 320
Cdd:PRK11929 267 PQNAGADV-QARDLRATAHGQVftlatpDGSYQ-LVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRME 344
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 639691732 321 ---LFKTDKGITVINDaYNASPTSMKAAIDLVGDMDGFANRILV 361
Cdd:PRK11929 345 rvgPTAGAQGPLVVVD-YAHTPDALAKALTALRPVAQARNGRLV 387
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
80-346 |
2.40e-22 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 98.92 E-value: 2.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 80 GVPVILVEDTLTALqqlaksyLKEEnpRVVGITGSNGKTTTKDMIHSVLQ-----TTYRV--HKTDGNFNNHIGlpltil 152
Cdd:TIGR01082 82 GIPVIRRAEMLAEL-------MRFR--HSIAVAGTHGKTTTTAMIAVILKeagldPTVVVggLVKEAGTNARLG------ 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 153 ampeGTEIAVLEMGMSAKGEIEFlsklaEPDAAVITNIGESHMQDLGSR-EAIADAKCEITKGLKEDGTFYYLGDEPLLR 231
Cdd:TIGR01082 147 ----SGEYLVAEADESDASFLHL-----QPNVAIVTNIEPDHLDTYGSSfERLKAAFEKFIHNLPFYGLAVICADDPVLR 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 232 QRANALARSVKTFG-ESEDCDIKVIHIHQLAEGTEFQVEG---YAQGFLIPVLGKHNVKNALAAIAIGQHFGLNERQIAQ 307
Cdd:TIGR01082 218 ELVPKATEQVITYGgSGEDADYRAENIQQSGAEGKFSVRGkgkLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILR 297
|
250 260 270
....*....|....*....|....*....|....*....
gi 639691732 308 GLMQTKLTGMRLELFKTDKGITVINDaYNASPTSMKAAI 346
Cdd:TIGR01082 298 ALANFQGVKRRFEILGEFGGVLLIDD-YAHHPTEIKATL 335
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
108-438 |
2.90e-17 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 83.48 E-value: 2.90e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 108 VVGITGSNGKTTTKDMIHSVLQTTYRVHKTDGNfnnhIGLPLtILAMPEGTE--IAVLEMgmsAKGEIEFLSKLAePDAA 185
Cdd:PRK14106 110 IVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGN----IGYPL-IDAVEEYGEddIIVAEV---SSFQLETIKEFK-PKVG 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 186 VITNIGESHMQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARSVKTFGESedcdikvihiHQLAEGT- 264
Cdd:PRK14106 181 CILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKARVIFFSRK----------SLLEEGVf 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 265 ------EFQVEGYAQGFL----IPVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTKLTGMRLELFKTDKGITVINDA 334
Cdd:PRK14106 251 vkngkiVISLGGKEEEVIdideIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKFINDS 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 335 YNASP-TSMKAaidlvgdMDGFANRILVLGDMLEMGSEEETYHFEVGEYIKpefidHVLTFGRLGAFIAEGAKKA-FGD- 411
Cdd:PRK14106 331 KGTNPdAAIKA-------LEAYETPIVLIAGGYDKGSDFDEFAKAFKEKVK-----KLILLGETAQEIAEAARKYgFDNi 398
|
330 340
....*....|....*....|....*..
gi 639691732 412 DRVSSYmdkEELKKKLADVAGPDDVVL 438
Cdd:PRK14106 399 LFAETL---EEAVKKAYEIAKPGDVVL 422
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
103-366 |
4.88e-15 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 76.68 E-value: 4.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 103 EENPRVVGITGSNGKTTTKDMIHSVLQTT-YRVH--------------KTDGN----------------FNNHIGLP--- 148
Cdd:COG0285 37 QRKLPVIHVAGTNGKGSTAAMLESILRAAgYRVGlytsphlvrfneriRINGEpisdeelvealeevepAVEEVDAGppt 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 149 ----LTILAM----PEGTEIAVLEMGM-------SAkgeieflsklAEPDAAVITNIGESHMQDLGS-REAIADAKCEIt 212
Cdd:COG0285 117 ffevTTAAAFlyfaEAPVDVAVLEVGLggrldatNV----------IDPLVSVITSIGLDHTDFLGDtLEEIAREKAGI- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 213 kgLKEDGTFYY--LGDEPL--LRQRANALARSVKTFGesEDCDIKVIHIHQLAEGTEfqvEGYAQGFLIPVLGKHNVKNA 288
Cdd:COG0285 186 --IKPGVPVVTgdQQPEALevIEERAAELGAPLYRAG--RDFSVEEREGAVFSYQGP---GGEYEDLPLPLLGAHQAENA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 289 LAAIAI-----GQHFGLNERQIAQGLMQTKLTGmRLELFKTDKgiTVIND-AYNasPTSMKAAIDLVGDMDGFANRILVL 362
Cdd:COG0285 259 ALALAAlealrELGLPISEEAIREGLANARWPG-RLEVLSRGP--LVILDgAHN--PAGARALAETLKELFPFRKLHLVF 333
|
....
gi 639691732 363 GdML 366
Cdd:COG0285 334 G-ML 336
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
27-100 |
5.32e-15 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 69.96 E-value: 5.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 27 IHGVTTDTRKVSKGALFIPLIGEHFNGHTFASKAVELGAAAVLW-----NQTEANPP---FGVPVILVEDTLTALQQLAK 98
Cdd:pfam01225 2 IHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGhdaanNISPDNPEleaAKVPGIPVIDRREALAELAA 81
|
..
gi 639691732 99 SY 100
Cdd:pfam01225 82 AF 83
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
111-309 |
3.40e-14 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 74.85 E-value: 3.40e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 111 ITGSNGKTTTKDMIHSVLQTTyrvhKTDGNFNnhIG--LPLTILAMPEGTEIAVLEMGMSaKGEIEFLSklaePDAAVIT 188
Cdd:PRK14573 109 VSGSHGKTTVSSLITAIFQEA----KKDPSYA--IGglNQEGLNGYSGSSEYFVAEADES-DGSLKHYT----PEFSVIT 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 189 NIGESHMQDL-GSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRAnalarSVKTFGESEDCDIKVIHIHQLAEGTEFQ 267
Cdd:PRK14573 178 NIDNEHLSNFeGDRELLLASIQDFARKVQQINKCFYNGDCPRLKGCL-----QGHSYGFSSSCDLHILSYYQEGWRSYFS 252
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 639691732 268 VEGYAQGFL---IPVLGKHNVKNALAAIAIGQHFGLNERQIAQGL 309
Cdd:PRK14573 253 AKFLGVVYQdieLNLVGMHNVANAAAAMGIALTLGIDEGAIRNAL 297
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
22-349 |
7.00e-13 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 70.45 E-value: 7.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 22 FGEEQIHGVTTDTRKVSKGALFIPLiGEHFNgHTFASKAVELGAAAVLwnqTEANPPFGVPVILVEDTLTALQQLAKSYL 101
Cdd:PRK14022 29 YSGVQFDDISYDSRTADEGTLFFAK-GAYFK-HKFLQNAITQGLKLYV---SEKDYEVGIPQVIVPDIKKAMSLIAMEFY 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 102 keENP----RVVGITGSNGKTTTKDMIHSVLQTTYRV-------------HKTDGNFNNHIGLPLTIL---AMPEGTEIA 161
Cdd:PRK14022 104 --DNPqhklKLLAFTGTKGKTTAAYFAYHILKQLHKPamlstmnttldgeTFFKSALTTPESLDLFKMmaeAVDNGMTHL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 162 VLEMGMSA--KGEIEFLsklaEPDAAVITNIGESHMqdlgsreaiadakceitkGLKEDGTF--YYLGDEPLLRQ-RA-- 234
Cdd:PRK14022 182 IMEVSSQAylVGRVYGL----TFDVGVFLNITPDHI------------------GPIEHPTFedYFYHKRLLMENsKAvv 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 235 --------NALARSVK-----TFGESEDCDIKVIHihqlaeGTEFQVEGYAQG-FLIPVLGKHNVKNALAAIAIGQHFGL 300
Cdd:PRK14022 240 vnsdmdhfSELLEQVTpqehdFYGIDSENQIMASN------AFSFEATGKLAGtYDIQLIGKFNQENAMAAGLACLRLGA 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 639691732 301 NERQIAQGLMQTKLTGmRLELFKTDKGITVINDaYNASPTSMKAAIDLV 349
Cdd:PRK14022 314 SLEDIQKGIAQTPVPG-RMEVLTQSNGAKVFID-YAHNGDSLNKLIDVV 360
|
|
| folC |
TIGR01499 |
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of ... |
103-349 |
2.60e-11 |
|
folylpolyglutamate synthase/dihydrofolate synthase; This model represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]
Pssm-ID: 273659 [Multi-domain] Cd Length: 397 Bit Score: 65.00 E-value: 2.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 103 EENPRVVGITGSNGKTTTKDMIHSVLQTT-YRVHK--------------TDG-----------------NFNNHIGLP-- 148
Cdd:TIGR01499 15 QDLYPVIHVAGTNGKGSTCAFLESILRAAgYKVGLftsphlvsfnerirINGepisdeelaqafeqvrpILESLSQQPty 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 149 ---LTILAM----PEGTEIAVLEMGMSakGEIEfLSKLAEPDAAVITNIGESHMQDLG-SREAIADAKCEITKGlkedGT 220
Cdd:TIGR01499 95 felLTLLAFlyfaQAQVDVAVLEVGLG--GRLD-ATNVIEPLVSVITSIGLDHTEILGdTLEEIAWEKAGIIKE----GV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 221 FYYLGDEP-----LLRQRANALARSVKTFGesEDCDIKVIHIHQLAEGTEFQvegYAQGFLIPVLGKHNVKNALAAIA-- 293
Cdd:TIGR01499 168 PIVTGEQEpealnVLKKKAQEKGAPLFVVG--RDFNYSETDENYLSFSGANL---FLEPLALSLLGDHQQENAALALAal 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 639691732 294 --IGQHF-GLNERQIAQGLMQTKLTGmRLELFKTDKGITVINDAYNasPTSMKAAIDLV 349
Cdd:TIGR01499 243 evLGKQNpKLSEEAIRQGLANTIWPG-RLEILSEDNPNILLDGAHN--PHSAEALAEWF 298
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
108-311 |
5.64e-11 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 64.79 E-value: 5.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 108 VVGITGSNGKTTTKDMIHSVLQTT----------------YRVHKTD--GNFNNHiglplTILAMPEgTEIAVLEmgmSA 169
Cdd:PRK14016 482 IVAVTGTNGKTTTTRLIAHILKLSgkrvgmtttdgvyidgRLIDKGDctGPKSAR-----RVLMNPD-VEAAVLE---TA 552
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 170 KGEIefLSK-LA--EPDAAVITNIGESH--MQDLGSREAIADAKCEITKGLKEDGTFYYLGDEPLLRQRANALARSVKTF 244
Cdd:PRK14016 553 RGGI--LREgLAydRCDVGVVTNIGEDHlgLGGINTLEDLAKVKRVVVEAVKPDGYAVLNADDPMVAAMAERCKGKVIFF 630
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 245 geSEDCDIKVI--HIHQ-------------LAEG-TEFQVEGYAQgflIPVL--GK--HNVKNALAAIAIGQHFGLNERQ 304
Cdd:PRK14016 631 --SMDPDNPVIaeHRAQggravyvegdyivLAEGgWEIRIISLAD---IPLTlgGKagFNIENALAAIAAAWALGIDIEL 705
|
....*..
gi 639691732 305 IAQGLMQ 311
Cdd:PRK14016 706 IRAGLRT 712
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
315-394 |
6.61e-11 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 58.51 E-value: 6.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 315 TGMRLELFKTDKGITVINDaYNASPTSMKAAIDLVGDMDGFaNRILVLGDMLEmgsEEETYHFEVGEYIKPEFIDHVLTF 394
Cdd:pfam02875 1 VPGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFPG-RLILVFGGMGD---RDAEFHALLGRLAAALADVVILTG 75
|
|
| F430_CfbE |
NF033197 |
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in ... |
107-363 |
2.67e-06 |
|
coenzyme F430 synthase; Members of this family are coenzyme F430 synthase, involving in synthesizing coenzyme F430, which is used in methanogens by coenzyme M reductase. Members of this family are restricted to archaeal methanogens, and resemble (and may be misannotated as) MurD, an enzyme of bacterial cell wall biosynthesis.
Pssm-ID: 467992 [Multi-domain] Cd Length: 419 Bit Score: 49.63 E-value: 2.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 107 RVVGITGSNGKTTTKDMIHSVLQTTYRV-HKTDGNFNNHIGL--------PLTILAMPEGTEiavlEMGMSAKGEIEF-- 175
Cdd:NF033197 93 KFIEITGVKGKTTTAELLAHILSDEYVLlHTSRGTERYPEGElsnkgsitPASILNALELAE----EIGIDDYGFLIFev 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 176 -LSKLAEPDAAVITNIGESHMQDLGSREAIaDAKCEITKGLKEDGTF-----YYLGDEPLLRQRANALARSVKTFGESED 249
Cdd:NF033197 169 sLGGTGAGDVGIITNILEDYPIAGGKRSAS-AAKLQSLKNAKVGSINvadlgIYINGKNKLVITVAGVEILSKYPLRFKY 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 250 CDikvihihqlaegTEFQVEGYaqgflipVLGKHNVKNALAAIAIGQHFGLNERQIAQGLMQTK-LTGMrlELFKTDKGI 328
Cdd:NF033197 248 GN------------TEFEFNPL-------LFGPHYRENSLFAIEAALNLGVDPEDIISALKGFKgLPGR--MAVKKEGGV 306
|
250 260 270
....*....|....*....|....*....|....*....
gi 639691732 329 TVINdayNASP-TSMKA---AIDLVGDMDGfaNRILVLG 363
Cdd:NF033197 307 VIVD---NINPgLNVKAieyALDDALELLG--DGTLVIG 340
|
|
| PLN02913 |
PLN02913 |
dihydrofolate synthetase |
156-349 |
3.75e-06 |
|
dihydrofolate synthetase
Pssm-ID: 178501 [Multi-domain] Cd Length: 510 Bit Score: 49.05 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 156 EGTEIAVLEMGMSAKGEIEFLSKLAEPDAAVITNIGESHMQDL-GSREAIADAKCEITKglkeDGTFYYLGD------EP 228
Cdd:PLN02913 172 ENVDIAVIEAGLGGARDATNVIDSSGLAASVITTIGEEHLAALgGSLESIALAKSGIIK----QGRPVVLGGpflphiES 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 639691732 229 LLRQRANALARSV-KTFGESEDCDIKVIHIhqlAEGTEFQ-------VEGYAQGFL------IPVLGKHNVKNALAAIAI 294
Cdd:PLN02913 248 ILRDKASSMNSPVvSASDPGVRSSIKGIIT---DNGKPCQscdivirVEKDDPLFIelsdvnLRMLGSHQLQNAVTAACA 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 639691732 295 G-----QHFGLNERQIAQGLMQTKLTGMRLELFKTD------KGITVINDAYNaSPTSMKAAIDLV 349
Cdd:PLN02913 325 AlclrdQGWRISDASIRAGLENTNLLGRSQFLTSKEaevlglPGATVLLDGAH-TKESAKALVDTI 389
|
|
| |
