Protein Kinases, catalytic domain; The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases, and choline kinases. These proteins catalyze the transfer of the gamma-phosphoryl group from ATP to hydroxyl groups in specific substrates such as serine, threonine, or tyrosine residues of proteins.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640508570  54 GLTAEVFHLKVEGHHWCLkRRRHDSLVANVDgrtaflteleRRREIEALRELHPtilANVVCTCFGS-ARAGVLVSPWLR 132
Cdd:cd05151    9 GLTNKNYLVEVAGKKYVL-RIPGAGTELLID----------RENEKANSKAAAE---LGIAPEVIYFdPETGVKITEFIE 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640508570 133 GVPVHE---LNERNLAQMLAVQAELAHWGWFDW-----DPSPGNLLDDGQQISVFDFGYmwpfdprhefnsNGLTDPAF 203
Cdd:cd05151   75 GATLLTndfSDPENLERIAALLRKLHSSPLEDLvlchnDLVPGNFLLDDDRLYLIDWEY------------AGMNDPLF 141

Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic choline kinases, as well as eukaryotic ethanolamine kinase. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. Bacterial ChoK is also referred to as licA protein. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640508570  54 GLTAEVFHLKVEGHHWCLkRRRHDSLVANVDgrtaflteleRRREIEALRELHPtilANVVCTCFGS-ARAGVLVSPWLR 132
Cdd:cd05151    9 GLTNKNYLVEVAGKKYVL-RIPGAGTELLID----------RENEKANSKAAAE---LGIAPEVIYFdPETGVKITEFIE 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640508570 133 GVPVHE---LNERNLAQMLAVQAELAHWGWFDW-----DPSPGNLLDDGQQISVFDFGYmwpfdprhefnsNGLTDPAF 203
Cdd:cd05151   75 GATLLTndfSDPENLERIAALLRKLHSSPLEDLvlchnDLVPGNFLLDDDRLYLIDWEY------------AGMNDPLF 141

Choline Kinase and similar proteins; This subfamily is composed of bacterial and eukaryotic choline kinases, as well as eukaryotic ethanolamine kinase. ChoK catalyzes the transfer of the gamma-phosphoryl group from ATP (or CTP) to its substrate, choline, producing phosphorylcholine (PCho), a precursor to the biosynthesis of two major membrane phospholipids, phosphatidylcholine (PC), and sphingomyelin (SM). Although choline is the preferred substrate, ChoK also shows substantial activity towards ethanolamine and its N-methylated derivatives. Bacterial ChoK is also referred to as licA protein. ETNK catalyzes the transfer of the gamma-phosphoryl group from CTP to ethanolamine (Etn), the first step in the CDP-Etn pathway for the formation of the major phospholipid, phosphatidylethanolamine (PtdEtn). Unlike ChoK, ETNK shows specific activity for its substrate and displays negligible activity towards N-methylated derivatives of Etn. ChoK plays an important role in cell signaling pathways and the regulation of cell growth. The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and phosphoinositide 3-kinase (PI3K).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640508570  54 GLTAEVFHLKVEGHHWCLkRRRHDSLVANVDgrtaflteleRRREIEALRELHPtilANVVCTCFGS-ARAGVLVSPWLR 132
Cdd:cd05151    9 GLTNKNYLVEVAGKKYVL-RIPGAGTELLID----------RENEKANSKAAAE---LGIAPEVIYFdPETGVKITEFIE 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640508570 133 GVPVHE---LNERNLAQMLAVQAELAHWGWFDW-----DPSPGNLLDDGQQISVFDFGYmwpfdprhefnsNGLTDPAF 203
Cdd:cd05151   75 GATLLTndfSDPENLERIAALLRKLHSSPLEDLvlchnDLVPGNFLLDDDRLYLIDWEY------------AGMNDPLF 141

Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins; This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640508570  39 RLKEDHPAVLKVYRHGLTAEV----FHLK-----VEGHHWCLKRRRHDSLVANVdgRTAFLTELERRRE---IEALREL- 105
Cdd:cd05121   50 RLKDGREVAVKVQRPGIEEIIeadlRILRrlarlLERLSPLLRRLDLVAIVDEF--ARSLLEELDFRREarnAERFRKNl 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640508570 106 --HPTILANVVCTCFGSARagVLVSPWLRGVPVHELNE------------RNLAQMLAVQAeLAHwGWFDWDPSPGNLL- 170
Cdd:cd05121  128 kdSPDVYVPKVYPELSTRR--VLVMEYIDGVKLTDLEAlraagidrkelaRRLVDAYLKQI-FED-GFFHADPHPGNILv 203

                        170
                 ....*....|....
gi 640508570 171 DDGQQISVFDFGYM 184
Cdd:cd05121  204 LPDGRIALLDFGMV 217