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Conserved domains on  [gi|640723891|ref|WP_025146944|]
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MULTISPECIES: adenylosuccinate synthase [Bacillus]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10011626)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  3.40.440.10|3.90.170.10|1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0044208|GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  8244965|11916378|6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-429 0e+00

adenylosuccinate synthetase; Provisional


:

Pssm-ID: 234904  Cd Length: 430  Bit Score: 791.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALL 80
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  81 EELKYLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEK 159
Cdd:PRK01117  81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 160 LERNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTS 239
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 240 SNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARR 319
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 320 VSGLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVER 399
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                        410       420       430
                 ....*....|....*....|....*....|
gi 640723891 400 VSELTGIQLSMFSVGPDRNQTNIVRNVYEA 429
Cdd:PRK01117 401 IEELTGVPISIISTGPDRDQTIILRDPFAA 430
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-429 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 791.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALL 80
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  81 EELKYLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEK 159
Cdd:PRK01117  81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 160 LERNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTS 239
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 240 SNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARR 319
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 320 VSGLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVER 399
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                        410       420       430
                 ....*....|....*....|....*....|
gi 640723891 400 VSELTGIQLSMFSVGPDRNQTNIVRNVYEA 429
Cdd:PRK01117 401 IEELTGVPISIISTGPDRDQTIILRDPFAA 430
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-425 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 764.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   3 SVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEE 82
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  83 LKYLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLE 161
Cdd:COG0104   81 IDGLEARGVDVrSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 162 RNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSN 241
Cdd:COG0104  161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 242 PIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVS 321
Cdd:COG0104  241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 322 GLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVS 401
Cdd:COG0104  321 GLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIE 400

                        410       420
                 ....*....|....*....|....
gi 640723891 402 ELTGIQLSMFSVGPDRNQTnIVRN 425
Cdd:COG0104  401 ELLGVPISIVSVGPDREQT-IVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-420 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 729.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891    5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEELK 84
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   85 YLHDRGVS-TDNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLERN 163
Cdd:pfam00709  81 ELEERGIDvPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  164 LVEKNRLFEKMYDtEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSNPI 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  244 AGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGL 323
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  324 TDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVSEL 403
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*..
gi 640723891  404 TGIQLSMFSVGPDRNQT 420
Cdd:pfam00709 400 LGVPIKIISVGPDREQT 416
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-420 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 690.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891     3 SVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEE 82
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891    83 LKYLHDRGV-STDNLRVSNRAHVILPYHLKQDELEEASKgdnkIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLE 161
Cdd:smart00788  81 IEELEAKGVdVKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   162 RNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSN 241
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   242 PIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVS 321
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   322 GLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVS 401
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410
                   ....*....|....*....
gi 640723891   402 ELTGIQLSMFSVGPDRNQT 420
Cdd:smart00788 397 ELVGVPVSIISTGPDREQT 415
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 5-427 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 618.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891    5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEELK 84
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   85 YLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLERN 163
Cdd:TIGR00184  81 YLEKRGISVrDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  164 LVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSNPI 243
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  244 AGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGL 323
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  324 TDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVSEL 403
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEEL 400

                         410       420
                  ....*....|....*....|....
gi 640723891  404 TGIQLSMFSVGPDRNQTNIVRNVY 427
Cdd:TIGR00184 401 TGVPVTIISTGPEREQTIDLRKEL 424
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 2-420 8.96e-174

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 488.55  E-value: 8.96e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   2 SSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLE 81
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  82 ELKYLHDRGV-STDNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADlldreafkekl 160
Cdd:cd03108   81 EIEELEKKGIdVKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 161 ernlveknrlfekmydtegfsveeifeeyfeygqqiaQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSS 240
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 241 NPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRV 320
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 321 SGLTDLSLNSIDVltgiptlkicvaykyngevidevpanlnilakcepvyeelpgwteditgvrsldelpeNARKYVERV 400
Cdd:cd03108  273 NGLTELALTKLDV----------------------------------------------------------NAQKYIERI 294

                        410       420
                 ....*....|....*....|
gi 640723891 401 SELTGIQLSMFSVGPDRNQT 420
Cdd:cd03108  295 EELLGVPITYISVGPDREQT 314
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
5-322 8.78e-37

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 135.96  E-value: 8.78e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQ-GGNNAGHTIV-FGGVKYKLHLIPSGIFY-KEKICVIGNGLVVDPKALLE 81
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIdDEGRKFVHRMLPNGIVSpPLKQVLIGPGSEIDLEVLRE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  82 ELKYLHDRGVST-DNLRVSNRAHVILpyhlKQDELEEASKGDNKIGTTKKGIGPAYMDK----AARIGIRMADLLDREAF 156
Cdd:NF038379  83 EIEELEDAGHDVgKRLLIHEQATVIE----LHKHVEEEAGPMTKIGSTKKGIGAARAAKirrnPSTLGDAEGDFGEGAVR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 157 KEKLErnlveknrlfekmydtegfsveeifeeyfeygqqIAQYVCDTSVVLnDALDNNHRVLFEGAQGVMLDIDHGTYPF 236
Cdd:NF038379 159 DQPWE----------------------------------IAERVVDNALYD-FALQAAERIQIEGTQGYSLGLHAGFYPY 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 237 VTSSN--PIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGD-----GPFPTELH-DEIGhqireVGREYGTTTGRPRRVGW 308
Cdd:NF038379 204 CTSRDctPADFLADAGIPLPNVDAFKVVGTARTYPIRVAGwsgnsYPDQGETTwEELG-----LPEELTTVTKKVRRVGT 278

                        330
                 ....*....|....
gi 640723891 309 FDSVVVRHARRVSG 322
Cdd:NF038379 279 FSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 1-429 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 791.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALL 80
Cdd:PRK01117   1 MKNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  81 EELKYLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEK 159
Cdd:PRK01117  81 KEIDELEARGVDVrERLRISERAHLILPYHRALDKAREKARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPETFAEK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 160 LERNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTS 239
Cdd:PRK01117 161 LEENLEYKNFLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHGTYPFVTS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 240 SNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARR 319
Cdd:PRK01117 241 SNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAVALRYAVR 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 320 VSGLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVER 399
Cdd:PRK01117 321 VNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPENARKYIKR 400

                        410       420       430
                 ....*....|....*....|....*....|
gi 640723891 400 VSELTGIQLSMFSVGPDRNQTNIVRNVYEA 429
Cdd:PRK01117 401 IEELTGVPISIISTGPDRDQTIILRDPFAA 430
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 3-425 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 764.56  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   3 SVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEE 82
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  83 LKYLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLE 161
Cdd:COG0104   81 IDGLEARGVDVrSRLRISERAHLILPYHRALDKAREEARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDPEVLREKLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 162 RNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSN 241
Cdd:COG0104  161 ELLEYKNFLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 242 PIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVS 321
Cdd:COG0104  241 TTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVALRYAVRIN 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 322 GLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVS 401
Cdd:COG0104  321 GLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENARAYVERIE 400

                        410       420
                 ....*....|....*....|....
gi 640723891 402 ELTGIQLSMFSVGPDRNQTnIVRN 425
Cdd:COG0104  401 ELLGVPISIVSVGPDREQT-IVRR 423
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
5-420 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 729.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891    5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEELK 84
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   85 YLHDRGVS-TDNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLERN 163
Cdd:pfam00709  81 ELEERGIDvPDRLFISDRAHLILPYHKALDGLREEARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLDPEVFREKLEAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  164 LVEKNRLFEKMYDtEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSNPI 243
Cdd:pfam00709 161 LELKNKLLEKLYG-EPLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGTYPYVTSSNTT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  244 AGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGL 323
Cdd:pfam00709 240 AGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYAVRINGV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  324 TDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVSEL 403
Cdd:pfam00709 320 TGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYVEFIEEL 399

                         410
                  ....*....|....*..
gi 640723891  404 TGIQLSMFSVGPDRNQT 420
Cdd:pfam00709 400 LGVPIKIISVGPDREQT 416
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 3-420 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 690.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891     3 SVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEE 82
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891    83 LKYLHDRGV-STDNLRVSNRAHVILPYHLKQDELEEASKgdnkIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLE 161
Cdd:smart00788  81 IEELEAKGVdVKDRLFISDRAHLILPYHIALDKAREKAR----IGTTGRGIGPAYEDKVARRGIRVGDLFDEEVLREKLE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   162 RNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSN 241
Cdd:smart00788 157 ELLDYKNFLLKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDIDHGTYPYVTSSN 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   242 PIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVS 321
Cdd:smart00788 237 TTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLLRYAVRIN 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   322 GLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVS 401
Cdd:smart00788 317 GITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAKKYIERIE 396

                          410
                   ....*....|....*....
gi 640723891   402 ELTGIQLSMFSVGPDRNQT 420
Cdd:smart00788 397 ELVGVPVSIISTGPDREQT 415
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 5-427 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 618.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891    5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEELK 84
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   85 YLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLERN 163
Cdd:TIGR00184  81 YLEKRGISVrDRLFVSYRCHLILPYHKKLDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEAFAEKAKNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  164 LVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSNPI 243
Cdd:TIGR00184 161 LEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPYVTSSNTT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  244 AGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGL 323
Cdd:TIGR00184 241 AGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYACRLNGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  324 TDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVSEL 403
Cdd:TIGR00184 321 TQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYIERIEEL 400

                         410       420
                  ....*....|....*....|....
gi 640723891  404 TGIQLSMFSVGPDRNQTNIVRNVY 427
Cdd:TIGR00184 401 TGVPVTIISTGPEREQTIDLRKEL 424
PLN02513 PLN02513
adenylosuccinate synthase
 1-424 3.40e-177

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 501.48  E-value: 3.40e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVV-GTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFG-GVKYKLHLIPSGIFYKEKICVIGNGLVVDPKA 78
Cdd:PLN02513   1 LSQVSAVlGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYNDeGKKFALHLVPSGILNEKTTCVIGNGVVVHLPG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  79 LLEELKYLHDRGVSTDN-LRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFK 157
Cdd:PLN02513  81 LFEEIDGLESNGVSCEGrLLVSDRAHLLFDFHQEVDGLREAELAGSKIGTTKRGIGPAYSSKATRNGLRVGDLRHMDTFA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 158 EKLERNLVEKNRLFEKmYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFV 237
Cdd:PLN02513 161 EKLRELLADAAARFEG-FEYDASMVEEEVEAYKKFAERLEPFITDTVHYLNEAIQAGKKILVEGAQATMLDIDFGTYPFV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 238 TSSNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHA 317
Cdd:PLN02513 240 TSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVALKYS 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 318 RRVSGLTDLSLNSIDVLTGIPTLKICVAYKY-NGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKY 396
Cdd:PLN02513 320 CQINGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAAAQAY 399

                        410       420
                 ....*....|....*....|....*...
gi 640723891 397 VERVSELTGIQLSMFSVGPDRNQTnIVR 424
Cdd:PLN02513 400 VERIEELVGVPVHYIGVGPGRDAL-IVK 426
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 2-420 8.96e-174

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 488.55  E-value: 8.96e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   2 SSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLE 81
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  82 ELKYLHDRGV-STDNLRVSNRAHVILPYHLKQDELEEASKGDNKIGTTKKGIGPAYMDKAARIGIRMADlldreafkekl 160
Cdd:cd03108   81 EIEELEKKGIdVKGRLLISDRAHLVFPYHQELDGLEEKERGGKKIGTTKRGIGPAYADKAARTGIRVGD----------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 161 ernlveknrlfekmydtegfsveeifeeyfeygqqiaQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSS 240
Cdd:cd03108  150 -------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGTYPYVTSS 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 241 NPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRV 320
Cdd:cd03108  193 NTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYAVRI 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 321 SGLTDLSLNSIDVltgiptlkicvaykyngevidevpanlnilakcepvyeelpgwteditgvrsldelpeNARKYVERV 400
Cdd:cd03108  273 NGLTELALTKLDV----------------------------------------------------------NAQKYIERI 294

                        410       420
                 ....*....|....*....|
gi 640723891 401 SELTGIQLSMFSVGPDRNQT 420
Cdd:cd03108  295 EELLGVPITYISVGPDREQT 314
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 4-424 2.21e-170

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 484.53  E-value: 2.21e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   4 VVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEEL 83
Cdd:PTZ00350  15 VVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLEEI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  84 KYLHDRGVS-TDNLRVSNRAHVILPYHLKQDELEEASKGDN--KIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKL 160
Cdd:PTZ00350  95 EQLTKKGINlLGRLYISDRAHLVFDLHQAIDGIQESEKGKGgtQIGTTKRGIGPCYSTKASRTGLRVGDLLNFETFEKKY 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 161 eRNLVEKnrlFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSS 240
Cdd:PTZ00350 175 -RKLVEK---LQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGTYPYVTSS 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 241 NPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRV 320
Cdd:PTZ00350 251 NTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALRYVQMI 330

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 321 SGLTDLSLNSIDVLTGIPTLKICVAYKYNGEV--IDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVE 398
Cdd:PTZ00350 331 NGFDSINLTKLDVLSGLKEIKICVNYKNKGTGleIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENAQKYVL 410

                        410       420
                 ....*....|....*....|....*.
gi 640723891 399 RVSELTGIQLSMFSVGPDRNQTnIVR 424
Cdd:PTZ00350 411 FIEELLGVPIVWIGVGPNRENM-IVK 435
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 5-420 3.93e-154

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 442.70  E-value: 3.93e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKIcVIGNGLVVDPKALLEELK 84
Cdd:PRK13786   4 IITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEID 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  85 YLHDRG--VSTDNLRVSNRAHVILPYHLKQDELEEASKgDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLER 162
Cdd:PRK13786  83 MLEKHGvkVDAEKLGIDAKTSIIMPYHIELDGLRESAR-TEKIGTTKRGIGFAYIDKIARDEVRMSDLVDKERLMRRLEE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 163 NLVEKNRLFEKMY-DTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTSSN 241
Cdd:PRK13786 162 LAPQKEKEIKELGgDPSIVRDEALIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLDVIHGTQKFVTSSS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 242 PIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVS 321
Cdd:PRK13786 242 TIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLLKKAIYLN 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 322 GLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPGWTEDITGVRSLDELPENARKYVERVS 401
Cdd:PRK13786 322 GYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENARNYVERLE 401

                        410
                 ....*....|....*....
gi 640723891 402 ELTGIQLSMFSVGPDRNQT 420
Cdd:PRK13786 402 ELMGVPIKYISVGPGREQT 420
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 1-420 1.52e-142

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 413.19  E-value: 1.52e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALL 80
Cdd:PRK13787   1 MPASLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  81 EELKYLHDRGVST-DNLRVSNRAHVILPYHLKQDELEEA-SKGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDReAFKE 158
Cdd:PRK13787  81 EECDRLQKEGFPVkDKLLLSDACHLLFPYHSQIDSARETtSSQEHKIGTTKKGIGICYADKMMRTGLRVGDLLDK-SYKR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 159 KLERNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVT 238
Cdd:PRK13787 160 RLKHLVDEKNRELDKLYGMPPVSYNDINDGLKFFLSKVGKNIINTAYYLDTELKKGKRVLLEGAQGTGLDVDFGTYPYVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 239 SSNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHAR 318
Cdd:PRK13787 240 SSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEMLKHSV 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 319 RVSGLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLniLAKCEPVYEELPGWTEDITGVRSLDELPENARKYVE 398
Cdd:PRK13787 320 RINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPSQG--LEKVEPLYEEFPGWKDDISGINEFQKLPEKCKNYIS 397

                        410       420
                 ....*....|....*....|..
gi 640723891 399 RVSELTGIQLSMFSVGPDRNQT 420
Cdd:PRK13787 398 ALEKWIGVKINLVSTGPDRKDT 419
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 3-427 6.72e-139

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 405.30  E-value: 6.72e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   3 SVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFyKEKICVIGNGLVVDPKALLEE 82
Cdd:PRK13785   2 TVTIVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAV-RGKIGVLGNGCVVNPETLFDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  83 LKYLHDRGVSTDnLRVSNRAHVILPYHLKQDELEEASKGDN--KIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKL 160
Cdd:PRK13785  81 IDALRERGLDPD-VRVAERAHVILPYHRVLDGIEEEAKSDSdlEVGTTGRGIGPTYEDKAGRRGVRVGDLLDPDVLRDRL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 161 ERNLVEKNRLFEKMYD------TEGFSVEEIFEEYFEYGQQIAQ--YVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHG 232
Cdd:PRK13785 160 EYVVPQKRALAEDVYGldasetPEAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDGDNVMLEGAQGTSIDIDHG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 233 TYPFVTSSNPIAGGVTVGTGVGPAKVTR--VVGVCKAYTSRVGDGPFPTEL---------------HDEIGHQIREVGRE 295
Cdd:PRK13785 240 NYPYVTSSNPTAGGAATGTGLGPTVVGQgeVVGIVKAYLSRVGSGPLPTELggvegdtpdeggrpdEEELATYIREEGGE 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 296 YGTTTGRPRRVGWFDSVVVRHARRVSGLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNILAKCEPVYEELPG 375
Cdd:PRK13785 320 YGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPNFRSFDG 399

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 640723891 376 WTE-DITGVRS--LDELPENARKYVERVSELTGIQLSMFSVGPDRNQTNIVRNVY 427
Cdd:PRK13785 400 WPEvDWAAVAEegYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVLENPF 454
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 1-420 1.13e-138

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 402.65  E-value: 1.13e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALL 80
Cdd:PRK13788   1 MPGIAIIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  81 EELKYLHDRGVSTDnLRVSNRAHVILPYHLKQDEleeaskGDNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKL 160
Cdd:PRK13788  81 EERENLRAGGLNPK-LLISERAHLVLPHHKYVDG------RKNFVGTTGRGIGPAYSDRARRVGIRFGDLLDEAVLRERV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 161 ERNLVEK-NRLFEKMYDTegfsVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVTS 239
Cdd:PRK13788 154 ERLLEAKpNSTREAGWDT----VEKALADLAPMREILLPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYPYVTS 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 240 SNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVG----REYGTTTGRPRRVGWFDSVVVR 315
Cdd:PRK13788 230 SHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVLLK 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 316 HARRVSGLTDLSLNSIDVLTGIPTLKICVAYKYNGevidevpanlnilakcEPVYEELPGWTeDITGVRSLDELPENARK 395
Cdd:PRK13788 310 YACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDG----------------QPVYKELPGWG-DLDGVKSREALPKEAQA 372

                        410       420
                 ....*....|....*....|....*
gi 640723891 396 YVERVSELTGIQLSMFSVGPDRNQT 420
Cdd:PRK13788 373 YLELIEETTGVPVVMFSTSPRREDT 397
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 5-415 2.61e-134

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 391.77  E-value: 2.61e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALLEELK 84
Cdd:PRK13783   4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  85 YLHDR-GVSTDNLRVSNRAHVILPYHLKQDELEEASKGdNKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKEKLERN 163
Cdd:PRK13783  84 ELKEKfPDYSGRIFISELAHVVLPVHKELDEIIESVRK-NAIGTTKRGIGPAYADKVMRVGVRLADLFDEEKLREFLEKI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 164 LVEKNRLFEKMYDTEgfsveEIFEEYFEYGQQIAQYVCDtSVVLNDALDNNhRVLFEGAQGVMLDIDHGTYPFVTSSNPI 243
Cdd:PRK13783 163 LSLYKKLYGIEFDVE-----KMMEDLLTFYEKIKDLVVS-PVEIKRILEEK-SVLFEGTQGVLLDLDVGTYPYVTSSNCS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 244 AGGVTVGTGVgPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGL 323
Cdd:PRK13783 236 TTGVSAGMGF-PVKVDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEVSGV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 324 TDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEvPANLNILAKCEPVYEELPGWteditgvRSLDElpENARKYVERVSEL 403
Cdd:PRK13783 315 DSLVMTKADVLNGFEKIKVCVRYEIGGKEVRD-PSSLRDLEKAEPVYEEFDGW-------KSLED--KNFLKFVDFIERE 384

                        410
                 ....*....|..
gi 640723891 404 TGIQLSMFSVGP 415
Cdd:PRK13783 385 TGRKIAYISTGP 396
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 1-419 2.19e-115

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 344.31  E-value: 2.19e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVVGTQWGDEGKGKITDFLSEHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALL 80
Cdd:PRK13784   1 MSNIVIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  81 EELKYLHDRGV--STDNLRVSNRAHVILPYHLKQDELEEASKGDnKIGTTKKGIGPAYMDKAARIGIRMADLLDREAFKE 158
Cdd:PRK13784  81 EEITRLQAKGIaiSAENLFVSESCTIITSYHKLLDAVRESNTSE-KIGTTGKGIGPAYEDKVSRKGIKFKHLFDKDLLRS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 159 KLERNLVEKNRLFEKMYDTEGFSVEEIFEEYFEYGQQIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTYPFVT 238
Cdd:PRK13784 160 RLAISLAEKETLFRDLYKVEYPTLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYGTYPFVT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 239 SSNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVGREYGTTTGRPRRVGWFDSVVVRHAR 318
Cdd:PRK13784 240 SSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLPLLKYSA 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 319 RVSGLTDLSLNSIDVLTGIPTLKICVAYKYNGEVIDEVPANLNiLAKCEPVYEELPGWTEDITGVRslDELPENARKYVE 398
Cdd:PRK13784 320 KCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYCAYPGID-LYKVEPILVEMEPFSIDETVTK--DNMPAALKTYLK 396

                        410       420
                 ....*....|....*....|.
gi 640723891 399 RVSELTGIQLSMFSVGPDRNQ 419
Cdd:PRK13784 397 TIENHVGIPISSLAYGPSREQ 417
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 1-420 2.58e-75

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 238.24  E-value: 2.58e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   1 MSSVVVVGTQWGDEGKGKITDFLS--EHAEVVARYQGGNNAGHTIVFGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKA 78
Cdd:PRK04293   1 MTCTIVVGGFFGDEGKGKIIAYLAlkDKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  79 LLEELKYLHdrgvSTDNLRVSNRAHVILPYHLKQDeleeasKGD----NKIGTTKKGIGPAYMDKAARIGirmadlldre 154
Cdd:PRK04293  81 LLKEVEELN----VGGRVFVDYRCGIIEEKHVEED------RSDehlsKKIGSTGTGCGPANADRVLRRL---------- 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 155 afkeKLERNLVEknrlfekmydtegfsveeifeeyfeygqqIAQYVCDTSVVLNDALDNNHRVLFEGAQGVMLDIDHGTY 234
Cdd:PRK04293 141 ----KLAKDVEE-----------------------------LEKYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYYGTY 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 235 PFVTSSNPIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGDGPFPTELHDEIGHQIREVgrEYGTTTGRPRRVGWFDSVVV 314
Cdd:PRK04293 188 PYVTSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEAEKLGLV--EYGTVTGRRRRVGPFDFELA 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 315 RHARRVSGLTDLSLNSIDVLtgiptlkicvaYKyngevidevpanlnilakcepvyeelpgwteDITGVRSLDELPENAR 394
Cdd:PRK04293 266 RRAARINGATQIAITKLDKL-----------DK-------------------------------EAYGVTEYDKLPPEAK 303

                        410       420
                 ....*....|....*....|....*.
gi 640723891 395 KYVERVSELTGIQLSMFSVGPDRNQT 420
Cdd:PRK04293 304 KFIEEIEEELGVPVTLISTGPELEDT 329
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
5-322 8.78e-37

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 135.96  E-value: 8.78e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   5 VVVGTQWGDEGKGKITDFLSEHAEVVARYQ-GGNNAGHTIV-FGGVKYKLHLIPSGIFY-KEKICVIGNGLVVDPKALLE 81
Cdd:NF038379   3 VVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIdDEGRKFVHRMLPNGIVSpPLKQVLIGPGSEIDLEVLRE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  82 ELKYLHDRGVST-DNLRVSNRAHVILpyhlKQDELEEASKGDNKIGTTKKGIGPAYMDK----AARIGIRMADLLDREAF 156
Cdd:NF038379  83 EIEELEDAGHDVgKRLLIHEQATVIE----LHKHVEEEAGPMTKIGSTKKGIGAARAAKirrnPSTLGDAEGDFGEGAVR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 157 KEKLErnlveknrlfekmydtegfsveeifeeyfeygqqIAQYVCDTSVVLnDALDNNHRVLFEGAQGVMLDIDHGTYPF 236
Cdd:NF038379 159 DQPWE----------------------------------IAERVVDNALYD-FALQAAERIQIEGTQGYSLGLHAGFYPY 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891 237 VTSSN--PIAGGVTVGTGVGPAKVTRVVGVCKAYTSRVGD-----GPFPTELH-DEIGhqireVGREYGTTTGRPRRVGW 308
Cdd:NF038379 204 CTSRDctPADFLADAGIPLPNVDAFKVVGTARTYPIRVAGwsgnsYPDQGETTwEELG-----LPEELTTVTKKVRRVGT 278

                        330
                 ....*....|....
gi 640723891 309 FDSVVVRHARRVSG 322
Cdd:NF038379 279 FSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 4-164 1.28e-16

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 82.02  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891   4 VVVVGTQWGDEGKGKITDFLSEH--AEVVARYQGGNNAGHTIV-FGGVKYKLHLIPSGIFYKEKICVIGNGLVVDPKALL 80
Cdd:PTZ00351 172 IMVAGAFFGDEGKGKTVDAVAHHplCTCIARVNSGENAGHTVYdKAGRKFVFNLAPSGLLLPGKRNYIGPECVMDPVSFM 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640723891  81 E-ELKYLHDRGVS-TDNLRVSNRAhVILPYHLKQDELEEASKgdnkiGTTKKGIGPAYMDKAARIGIRMADLL-DREAFK 157
Cdd:PTZ00351 252 EkEIIQLIDAGIDyRDRLFIGNVC-IVTPYHKLLDLLGSAAN-----SSTLKGMAPVHGSKVMKRGIRLDHIFnDDETLR 325


                 ....*..
gi 640723891 158 EKLERNL 164
Cdd:PTZ00351 326 KRLEKDM 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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