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Conserved domains on  [gi|640724120|ref|WP_025147171|]
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MULTISPECIES: GNAT family N-acetyltransferase [Bacillus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 18514829)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  15581578|10940244|9175471
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 4.07e-41

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


:

Pssm-ID: 436212  Cd Length: 123  Bit Score: 138.19  E-value: 4.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120  157 IIQIDEDAFGTNREEFLKCRIIQSEQCIVIKDIQQNVLGYGMSIQTPENKIIGPVFAKNDAMAMRIVHYLAREHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 640724120  237 DVPEGKGNFMKELEITGFQKVNKPPIMMKNSDQLLKRNNEPYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 9-123 1.42e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 66.17  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   9 ERLRREKIEDIVALSSYIGWDYNREEIETILntgivygVVNEKEELIASAAIILYGETLASIGMVIVHPDYKGRGIGKAI 88
Cdd:COG1246    1 MTIRPATPDDVPAILELIRPYALEEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRL 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 640724120  89 TDLCVKSVSTQ--TPIVLIATDEGKPLYEKLGFRTVS 123
Cdd:COG1246   74 LEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 4.07e-41

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 138.19  E-value: 4.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120  157 IIQIDEDAFGTNREEFLKCRIIQSEQCIVIKDIQQNVLGYGMSIQTPENKIIGPVFAKNDAMAMRIVHYLAREHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 640724120  237 DVPEGKGNFMKELEITGFQKVNKPPIMMKNSDQLLKRNNEPYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 9-123 1.42e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 66.17  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   9 ERLRREKIEDIVALSSYIGWDYNREEIETILntgivygVVNEKEELIASAAIILYGETLASIGMVIVHPDYKGRGIGKAI 88
Cdd:COG1246    1 MTIRPATPDDVPAILELIRPYALEEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRL 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 640724120  89 TDLCVKSVSTQ--TPIVLIATDEGKPLYEKLGFRTVS 123
Cdd:COG1246   74 LEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 17-123 3.03e-09

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 54.20  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   17 EDIVALSSYIgwdyNREEIETILNTGIVYGVV-NEKEELIASAAIILYGEtlasIGMVIVHPDYKGRGIGKAITDLCVKS 95
Cdd:pfam13673   8 EGIETFYEFI----SPEALRERIDQGEYFFFVaFEGGQIVGVIALRDRGH----ISLLFVDPDYQGQGIGKALLEAVEDY 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 640724120   96 VSTQTP----IVLIATDEGKPLYEKLGFRTVS 123
Cdd:pfam13673  80 AEKDGIklseLTVNASPYAVPFYEKLGFRATG 111
PTZ00330 PTZ00330
acetyltransferase; Provisional
 64-120 1.32e-07

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 49.84  E-value: 1.32e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 640724120  64 GETLASIGMVIVHPDYKGRGIGKA-ITDLCVKSVSTQT-PIVLIATDEGKPLYEKLGFR 120
Cdd:PTZ00330  79 GKCVGHIEDVVVDPSYRGQGLGRAlISDLCEIARSSGCyKVILDCTEDMVAFYKKLGFR 137
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-94 3.46e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.03  E-value: 3.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 640724120  47 VVNEKEELIASAAIILYGETL--ASIGMVIVHPDYKGRGIGKAITDLCVK 94
Cdd:cd04301    3 VAEDDGEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEE 52
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 45-128 1.30e-03

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.08  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   45 YGVVNEKEELIASAA--IILYGETLASIGmviVHPDYKGRGIGKA-----ITDLCVKSVSTQTPIVLIATDEGKPLYEKL 117
Cdd:TIGR01575  33 YLLARIGGKVVGYAGvqIVLDEAHILNIA---VKPEYQGQGIGRAllrelIDEAKGRGVNEIFLEVRVSNIAAQALYKKL 109

                          90
                  ....*....|.
gi 640724120  118 GFRTVSYVSKY 128
Cdd:TIGR01575 110 GFNEIAIRRNY 120
 
Name Accession Description Interval E-value
Acetyltransf_18 pfam18014
Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that ...
 157-279 4.07e-41

Acetyltransferase (GNAT) domain; This entry represents a likely acetyltransferase enzyme that is related to pfam06852.


Pssm-ID: 436212  Cd Length: 123  Bit Score: 138.19  E-value: 4.07e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120  157 IIQIDEDAFGTNREEFLKCRIIQSEQCIVIKDIQQNVLGYGMSIQTPENKIIGPVFAKNDAMAMRIVHYLAREHNGKLRI 236
Cdd:pfam18014   1 VLELDREAFGADRSAFLKRRLKQADQVAVVRNEDGEIRGYGLARRCPAGLKIGPLVANNEEIALALIRALAANHEGPVRI 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 640724120  237 DVPEGKGNFMKELEITGFQKVNKPPIMMKNSDQLLKRNNEPYS 279
Cdd:pfam18014  81 DVPEENPALIALLESLGFEKVFECPRMVKGGPPLPERNETLYG 123
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 9-123 1.42e-13

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 66.17  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   9 ERLRREKIEDIVALSSYIGWDYNREEIETILntgivygVVNEKEELIASAAIILYGETLASIGMVIVHPDYKGRGIGKAI 88
Cdd:COG1246    1 MTIRPATPDDVPAILELIRPYALEEEIGEFW-------VAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRL 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 640724120  89 TDLCVKSVSTQ--TPIVLIATDEGKPLYEKLGFRTVS 123
Cdd:COG1246   74 LEALLAEARELglKRLFLLTTSAAIHFYEKLGFEEID 110
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
53-122 2.86e-11

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 58.38  E-value: 2.86e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 640724120  53 ELIASAAIILYGETLASIGMVIVHPDYKGRGIGKAITDLCVKSVSTQ---TPI--VLIATDEGKPLYEKLGFRTV 122
Cdd:COG3393    1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARgarTPFlyVDADNPAARRLYERLGFRPV 75
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
11-123 1.03e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 55.86  E-value: 1.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120  11 LRREKIEDIVALSSYI--GWDYNREE--IETILNTGIVYG--VVNEKEELIASAAI----ILYGETLASIGMVIVHPDYK 80
Cdd:COG3153    1 IRPATPEDAEAIAALLraAFGPGREAelVDRLREDPAAGLslVAEDDGEIVGHVALspvdIDGEGPALLLGPLAVDPEYR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 640724120  81 GRGIGKAITDLCVKSVSTQ--TPIVLIATDEGKPLYEKLGFRTVS 123
Cdd:COG3153   81 GQGIGRALMRAALEAARERgaRAVVLLGDPSLLPFYERFGFRPAG 125
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
50-123 1.30e-09

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 55.19  E-value: 1.30e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640724120  50 EKEELIASAAIILYGETLASIGMVIVHPDYKGRGIGKAITDLCVKSVSTQ--TPIVLIATDEGKPLYEKLGFRTVS 123
Cdd:COG2153   41 DDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERgaRRIVLSAQAHAVGFYEKLGFVPVG 116
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 17-123 3.03e-09

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 54.20  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   17 EDIVALSSYIgwdyNREEIETILNTGIVYGVV-NEKEELIASAAIILYGEtlasIGMVIVHPDYKGRGIGKAITDLCVKS 95
Cdd:pfam13673   8 EGIETFYEFI----SPEALRERIDQGEYFFFVaFEGGQIVGVIALRDRGH----ISLLFVDPDYQGQGIGKALLEAVEDY 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 640724120   96 VSTQTP----IVLIATDEGKPLYEKLGFRTVS 123
Cdd:pfam13673  80 AEKDGIklseLTVNASPYAVPFYEKLGFRATG 111
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 10-123 8.45e-09

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 53.13  E-value: 8.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120  10 RLRREKIEDIVALSSYIGWDynrEEIETILNTGIVYG--VVNEKEELIASAAIILYGETLASIGMVIVHPDYKGRGIGKA 87
Cdd:COG0454    2 SIRKATPEDINFILLIEALD---AELKAMEGSLAGAEfiAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKA 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 640724120  88 ITDLCV-----KSVSTQTPIVLIATDEGKPLYEKLGFRTVS 123
Cdd:COG0454   79 LLEALLewareRGCTALELDTLDGNPAAIRFYERLGFKEIE 119
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 47-120 8.90e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 48.60  E-value: 8.90e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 640724120   47 VVNEKEELIASAAIILYGETLASIG-MVIVHPDYKGRGIGKAITDLC--VKSVSTQTPIVLIATDEGKPLYEKLGFR 120
Cdd:pfam13508   7 VAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAeaAAKEGGIKLLELETTNRAAAFYEKLGFE 83
PTZ00330 PTZ00330
acetyltransferase; Provisional
 64-120 1.32e-07

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 49.84  E-value: 1.32e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 640724120  64 GETLASIGMVIVHPDYKGRGIGKA-ITDLCVKSVSTQT-PIVLIATDEGKPLYEKLGFR 120
Cdd:PTZ00330  79 GKCVGHIEDVVVDPSYRGQGLGRAlISDLCEIARSSGCyKVILDCTEDMVAFYKKLGFR 137
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 58-128 2.01e-07

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 48.11  E-value: 2.01e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640724120  58 AAIILYGETLASIGMVIVHPDYKGRGIGKAITDLCVKSVSTQ--TPIVLIATDEGKP---LYEKLGFRTVSYVSKY 128
Cdd:COG0456    4 LLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERgaRRLRLEVREDNEAaiaLYEKLGFEEVGERPNY 79
Eis COG4552
Predicted acetyltransferase [General function prediction only];
4-87 6.06e-07

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 50.28  E-value: 6.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   4 LEIRveRLRREKIEDIVALSSYI-GWDYNREEIET---ILNTGIVYGVVNEkEELIASAAII-----LYGETL--ASIGM 72
Cdd:COG4552    1 MEIR--PLTEDDLDAFARLLAYAfGPEPDDEELEAyrpLLEPGRVLGVFDD-GELVGTLALYpftlnVGGARVpmAGITG 77

                         90
                 ....*....|....*
gi 640724120  73 VIVHPDYKGRGIGKA 87
Cdd:COG4552   78 VAVAPEHRRRGVARA 92
PRK07757 PRK07757
N-acetyltransferase;
10-123 8.34e-07

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 47.50  E-value: 8.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120  10 RLRREKIEDIVALSSYIGwDYNREEI----------ETILNtgivYGVVNEKEELIASAAIILYGETLASIGMVIVHPDY 79
Cdd:PRK07757   3 EIRKARLSDVKAIHALIN-VYAKKGLmlprsldelyENIRD----FYVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDY 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 640724120  80 KGRGIGKAITDLCVKsvstqtpivlIATDEG----------KPLYEKLGFRTVS 123
Cdd:PRK07757  78 RGQGIGRMLVEACLE----------EARELGvkrvfaltyqPEFFEKLGFREVD 121
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 32-119 1.55e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 43.28  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   32 REEIETILNTGIVYGVVNEKEELIASAAIILYGETL--ASIGMVIVHPDYKGRGIGKA-ITDLCVKSVSTQTPIVLIATD 108
Cdd:pfam00583  22 DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPpvGEIEGLAVAPEYRGKGIGTAlLQALLEWARERGCERIFLEVA 101

                          90
                  ....*....|....*
gi 640724120  109 EG----KPLYEKLGF 119
Cdd:pfam00583 102 ADnlaaIALYEKLGF 116
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 6-121 8.38e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 41.40  E-value: 8.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120    6 IRveRLRREKIEDIVALSSYI-GWDY---NREEIETILNTGIVYGVvNEKEELIASAAII-----LYGETL--ASIGMVI 74
Cdd:pfam13527   1 IR--PLTEDEFDEVLRLLEYAfQDEDspeLREYFRPLLEEGRVLGA-FDDGELVSTLALYpfelnVPGKTLpaAGITGVA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 640724120   75 VHPDYKGRGIGKAITD--LCVKSVSTQTPIVLIATDEgkPLYEKLGFRT 121
Cdd:pfam13527  78 TYPEYRGRGVMSRLLRrsLEEMRERGVPLSFLYPSSY--PIYRRFGYEI 124
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 47-94 3.46e-04

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 38.03  E-value: 3.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 640724120  47 VVNEKEELIASAAIILYGETL--ASIGMVIVHPDYKGRGIGKAITDLCVK 94
Cdd:cd04301    3 VAEDDGEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEE 52
PRK09831 PRK09831
GNAT family N-acetyltransferase;
70-122 7.44e-04

GNAT family N-acetyltransferase;


Pssm-ID: 182099  Cd Length: 147  Bit Score: 39.17  E-value: 7.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 640724120  70 IGMVIVHPDYKGRGIGKAITDLCVKSVSTQTpivLIATDEGKPLYEKLGFRTV 122
Cdd:PRK09831  75 IDMLFVDPEYTRRGVASALLKPLIKSESELT---VDASITAKPFFERYGFQTV 124
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 45-128 1.30e-03

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.08  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   45 YGVVNEKEELIASAA--IILYGETLASIGmviVHPDYKGRGIGKA-----ITDLCVKSVSTQTPIVLIATDEGKPLYEKL 117
Cdd:TIGR01575  33 YLLARIGGKVVGYAGvqIVLDEAHILNIA---VKPEYQGQGIGRAllrelIDEAKGRGVNEIFLEVRVSNIAAQALYKKL 109

                          90
                  ....*....|.
gi 640724120  118 GFRTVSYVSKY 128
Cdd:TIGR01575 110 GFNEIAIRRNY 120
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 44-120 2.28e-03

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 36.54  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120   44 VYGVVneKEELIASAAIIL---YGEtlasIGMVIVHPDYKGRGIG----KAITDLCVKSVSTQTPIVLIATDEGKPLYEK 116
Cdd:pfam08445   1 VLGIY--RGDTGELAAWCLrlpGGE----LGALQTLPEHRRRGLGsrlvAALARGIAERGITPFAVVVAGNTPSRRLYEK 74


                  ....
gi 640724120  117 LGFR 120
Cdd:pfam08445  75 LGFR 78
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 52-123 2.63e-03

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 37.60  E-value: 2.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640724120  52 EELIASAAI---ILYGETLASIGmviVHPDYKGRGIGKA-----ITDLCVKSVST------QTPIVLIAtdegkpLYEKL 117
Cdd:PRK09491  48 NGQMAAFAItqvVLDEATLFNIA---VDPDYQRQGLGRAllehlIDELEKRGVATlwlevrASNAAAIA------LYESL 118


                 ....*.
gi 640724120 118 GFRTVS 123
Cdd:PRK09491 119 GFNEVT 124
PRK13688 PRK13688
N-acetyltransferase;
75-124 4.29e-03

N-acetyltransferase;


Pssm-ID: 237470  Cd Length: 156  Bit Score: 36.92  E-value: 4.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 640724120  75 VHPDYKGRGIGKAITDLcvkSVSTQTPIVLIATDEGKPLYEKLGFRTVSY 124
Cdd:PRK13688  87 VLPKYQNRGYGEMLVDF---AKSFQLPIKTIARNKSKDFWLKLGFTPVEY 133
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
73-122 6.84e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 36.51  E-value: 6.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 640724120  73 VIVHPDYKGRGIGKA----ITDLCVKS-VSTqtpIVLIATDEGKP---LYEKLGFRTV 122
Cdd:COG1247   86 IYVDPDARGRGIGRAlleaLIERARARgYRR---LVAVVLADNEAsiaLYEKLGFEEV 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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