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Conserved domains on  [gi|640727972|ref|WP_025150956|]
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MULTISPECIES: GntR family transcriptional regulator [Bacillus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448193)

GntR family transcriptional regulator simlar to MngR, which is involved in the regulation of mannosyl-glycerate transport and metabolism

CATH:  1.10.10.10
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  33509775|26172911|2060763

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-113 6.86e-45

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


:

Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 141.85  E-value: 6.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972   1 MKIEFSPNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVT-NEGE 79
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAeDARE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 640727972  80 KIMELRKDMAKELLHSFIDGMDNLGFSEEEILSI 113
Cdd:COG1725   81 LLEERREEFLEEALRELVAEARRLGLSLEELLEL 114
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-113 6.86e-45

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 141.85  E-value: 6.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972   1 MKIEFSPNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVT-NEGE 79
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAeDARE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 640727972  80 KIMELRKDMAKELLHSFIDGMDNLGFSEEEILSI 113
Cdd:COG1725   81 LLEERREEFLEEALRELVAEARRLGLSLEELLEL 114
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 2.03e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 83.27  E-value: 2.03e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640727972  10 PIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVT 75
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
15-74 4.80e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 66.83  E-value: 4.80e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972    15 VMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYV 74
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-74 1.06e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 63.40  E-value: 1.06e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640727972   12 YIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYV 74
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 14-71 8.16e-10

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 55.05  E-value: 8.16e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 640727972  14 QVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMG 71
Cdd:PRK15481   9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNG 66
 
Name Accession Description Interval E-value
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-113 6.86e-45

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 141.85  E-value: 6.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972   1 MKIEFSPNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVT-NEGE 79
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAeDARE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 640727972  80 KIMELRKDMAKELLHSFIDGMDNLGFSEEEILSI 113
Cdd:COG1725   81 LLEERREEFLEEALRELVAEARRLGLSLEELLEL 114
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 1-76 2.30e-23

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 93.35  E-value: 2.30e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640727972   1 MKIEFSPNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTN 76
Cdd:COG1167    3 IRLDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 2.03e-22

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 83.27  E-value: 2.03e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640727972  10 PIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVT 75
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-75 7.98e-20

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 81.06  E-value: 7.98e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972   6 SPNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVT 75
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA 70
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
15-74 4.80e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 66.83  E-value: 4.80e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972    15 VMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYV 74
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 12-74 1.06e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 63.40  E-value: 1.06e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640727972   12 YIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYV 74
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
7-76 1.45e-14

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 67.27  E-value: 1.45e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972   7 PNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTN 76
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 14-71 8.16e-10

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 55.05  E-value: 8.16e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 640727972  14 QVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMG 71
Cdd:PRK15481   9 EIFDSIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNG 66
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 14-79 5.52e-09

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 52.08  E-value: 5.52e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640727972  14 QVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTNEGE 79
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHE 71
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
14-85 1.83e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 47.61  E-value: 1.83e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640727972  14 QVMEYIKKEIVTGHLLPGDKIpSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVT----NEGEKIMELR 85
Cdd:COG1802   15 QVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAplspEEIRELYEVR 89
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-123 4.38e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 46.94  E-value: 4.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972   1 MKIEFSPNTPiYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTNEGEK 80
Cdd:PRK10225   1 MKSATSAQRP-YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGS 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 640727972  81 IMELRKDM-------------AKELLHSFIDGMDNLGFSEEEILSILRSSLSEKRE 123
Cdd:PRK10225  80 HNTDSPDAnvcndagpfellqARQLLESNIAEFAALQATREDIVKMRQALQLEERE 135
PRK14999 PRK14999
histidine utilization repressor; Provisional
 6-74 7.27e-07

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 46.08  E-value: 7.27e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 640727972   6 SPNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYV 74
Cdd:PRK14999   8 SAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
36-72 1.78e-06

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 44.91  E-value: 1.78e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 640727972  36 SVRELASELQVNPNTIQRTFQELERDGVVVT---RRGMGR 72
Cdd:COG2345   29 TAAELAEALGLTPNAVRRHLDALEEEGLVEReteRRGRGR 68
PRK11402 PRK11402
transcriptional regulator PhoB;
9-74 2.04e-06

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 44.83  E-value: 2.04e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 640727972   9 TPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYV 74
Cdd:PRK11402   8 QLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFV 73
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
15-77 5.12e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 43.86  E-value: 5.12e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 640727972  15 VMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTNE 77
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSS 77
IscR COG1959
DNA-binding transcriptional regulator, IscR family [Transcription];
28-69 5.37e-05

DNA-binding transcriptional regulator, IscR family [Transcription];


Pssm-ID: 441562  Cd Length: 141  Bit Score: 40.21  E-value: 5.37e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 640727972  28 LLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRG 69
Cdd:COG1959   18 LHPGGEPVTSKEIAERQGISPSYLEKILQKLRKAGLVESVRG 59
Rrf2 pfam02082
Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur ...
 28-74 1.30e-04

Iron-dependent Transcriptional regulator; Several proteins in this family form iron-sulfur clusters enabling iron dependent DNA transcription regulation. The iron binding is mediated by three conserved cysteine residues. Members of this family can also bind O-acetyl-L-serine, [Fe-S] and nitric oxide (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 396591 [Multi-domain]  Cd Length: 131  Bit Score: 38.69  E-value: 1.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 640727972   28 LLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRG-MGRYV 74
Cdd:pfam02082  17 LHPGGEPVTSEEIAERQNISPVYLEKILAKLRKAGLVESVRGaGGGYR 64
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 36-84 3.36e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 36.89  E-value: 3.36e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 640727972  36 SVRELASELQVNPNTIQRTFQELERDGVVVTRRG--MGRYVTNEGEKIMEL 84
Cdd:cd00090   22 TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREgrRVYYSLTDAERLLAL 72
PRK09764 PRK09764
GntR family transcriptional regulator;
8-77 3.38e-04

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 38.66  E-value: 3.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972   8 NTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTNE 77
Cdd:PRK09764   3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEE 72
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 15-103 3.90e-04

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 38.46  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972  15 VMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRG-MGRYVTNEGEKIMELRKDMAKELL 93
Cdd:PRK03837  18 VEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGeRARVSRPSADTIIGQLSGMAKDFL 97

                         90
                 ....*....|
gi 640727972  94 HSFIDGMDNL 103
Cdd:PRK03837  98 SQSPDGLAHL 107
PRK11523 PRK11523
transcriptional regulator ExuR;
3-80 4.23e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 38.29  E-value: 4.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 640727972   3 IEFSPNTPIYIQVMEYIKKEIVTGHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTNEGEK 80
Cdd:PRK11523   1 MEITEPRRLYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSNQPR 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
36-88 4.67e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.03  E-value: 4.67e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 640727972    36 SVRELASELQVNPNTIQRTFQELERDGVVVTRR-GMGRYVTNEGEKIMELRKDM 88
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRReGKRVYYSLTDEKVADLLEEL 65
HTH_41 pfam14502
Helix-turn-helix domain;
31-74 7.54e-04

Helix-turn-helix domain;


Pssm-ID: 433997 [Multi-domain]  Cd Length: 48  Bit Score: 35.16  E-value: 7.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 640727972   31 GDKIPSVRELASELQVNPNTIQRTFQELERDGVV-VTRRG-MGRYV 74
Cdd:pfam14502   3 GERLPTISEYSHKFELSVGTVQKALKKLEDMKAIqLERRGhNGTYL 48
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 26-74 1.05e-03

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 37.06  E-value: 1.05e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 640727972  26 GHLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYV 74
Cdd:PRK10079  27 QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV 75
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
27-110 1.79e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.95  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972  27 HLLPGDKIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTNEGEKIME--LRK-DMAKELLhsfidgMDNL 103
Cdd:COG1321   17 ELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALriVRRhRLLERFL------VEVL 90


                 ....*..
gi 640727972 104 GFSEEEI 110
Cdd:COG1321   91 GVDWDEA 97
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
 36-114 2.11e-03

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 36.59  E-value: 2.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 640727972  36 SVRELASELQVNPNTIQRTFQELERDGV-VVTRRG-MGRYVtnegekimeLRKDmakellhsfiDGMDNLGFSEEEILSI 113
Cdd:COG2378   21 TAAELAERLEVSERTIYRDIDALRELGVpIEAERGrGGGYR---------LRDG----------YRLPPLMLTEEEALAL 81


                 .
gi 640727972 114 L 114
Cdd:COG2378   82 L 82
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 37-110 3.87e-03

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 34.12  E-value: 3.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 640727972    37 VRELASELQVNPNTIQRTFQELERDGVVVTRRGMGRYVTNEGEKI--MELRKDM-AKELLHsfidgmDNLGFSEEEI 110
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLarRLLRKHRlLERFLV------DVLGVDEEEV 71
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
14-77 4.62e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 33.39  E-value: 4.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640727972   14 QVMEYIKKEivtGHLlpgdkipSVRELASELQVNPNTIQRTFQELERDGVVvtRRGMGRYVTNE 77
Cdd:pfam08220   4 QILELLKQQ---GTL-------SVEELAELLGVSEMTIRRDLNELEEQGLL--TRTHGGAVSNS 55
HTH_36 pfam13730
Helix-turn-helix domain;
35-62 7.34e-03

Helix-turn-helix domain;


Pssm-ID: 463970 [Multi-domain]  Cd Length: 55  Bit Score: 32.46  E-value: 7.34e-03
                          10        20
                  ....*....|....*....|....*...
gi 640727972   35 PSVRELASELQVNPNTIQRTFQELERDG 62
Cdd:pfam13730  26 PSVETLAKRLGLSRRTIQRAIKELEELG 53
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 9-72 8.81e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 34.51  E-value: 8.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 640727972   9 TPIYIQVMEYIKKEIVTGHLlpgdkIPSVRELASELQVNPNTIQRTFQELERDGVVVTRRGMGR 72
Cdd:COG1974    5 TKRQREILDFIKEYIRERGY-----PPSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKSR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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