|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11128 |
PRK11128 |
3-phenylpropionate MFS transporter; |
1-380 |
0e+00 |
|
3-phenylpropionate MFS transporter;
Pssm-ID: 236856 [Multi-domain] Cd Length: 382 Bit Score: 581.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 1 MVLQSTRWLALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLLIAPRVKDPSHLVSALRLLALLT 80
Cdd:PRK11128 1 MVLQPTRWLALSYFGYFFAYGVFLPFWSVWLKGQGYTPETIGLLLGAGLVARFLGSLLIAPRVKDPSQLIPALRLLALLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 81 LAFAVGFCFGNGWGWLMLVIAG-FNLFFSPLVPLTDALAATWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAI 159
Cdd:PRK11128 81 LLFAVAFWFGAHSFWLLFVAIGlFNLFFSPLVPLTDALANTWQKQIGLDYGKVRLWGSIAFVIGSALTGKLVSWFGEQAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 160 LYSLIFSVLAMLLGMLLKPSVMPQGEARTHSDTER-SLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEAGYSAS 238
Cdd:PRK11128 161 LWILTAGVASMLLGQLLRPTIMPQGESRQQESAGWpAWKALLKEPTVWRFLLCVSLLQGSHAAYYGFSAIYWQAAGYSAS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 239 TIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAA 318
Cdd:PRK11128 241 TIGYLWSLGVVAEVLIFAFSNRLFRRWSARDLLLLSAICGVVRWGLMGSTTALPWLIVIQILHCGTFTVCHLAAMRYIAA 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644363006 319 RQGQEVIRLQAVYSALAMGGGIAVMTVIAGFLFEHWQGGVFWVMAAVAVPALFIRPPAVSVS 380
Cdd:PRK11128 321 RPGSEVIRLQALYSALAMGGSIAIMTVLSGFLYQHLGAGVFWVMALVALPALFIRPKVVASF 382
|
|
| 2A0127 |
TIGR00902 |
phenyl proprionate permease family protein; This family of proteins is involved in the uptake ... |
1-377 |
1.44e-137 |
|
phenyl proprionate permease family protein; This family of proteins is involved in the uptake of 3-phenylpropionic acid. This uptake mechanism is for the metabolism of phenylpropanoid compounds and plays an important role in the natural degradative cycle of these aromatic molecules. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129980 Cd Length: 382 Bit Score: 397.38 E-value: 1.44e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 1 MVLQSTRWLALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLLIAPRVKDPSHLVSALRLLALLT 80
Cdd:TIGR00902 1 MQLQPFRWLALGFFGYFCAYGIFLPFFPAWLKGIGLGEEMIGLLIGAALIARFAGGLFFAPLIKDANHIIIALRLLALAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 81 LAFAVGFCFGNGWGWLMLVIAG-FNLFFSPLVPLTDALAATWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAI 159
Cdd:TIGR00902 81 AIFAAAFSAGAHNAWLLFIAIGlFALFFSAGMPIGDALANTWQKQFGLDYGKVRLIGSAAFIIGSALFGGLIGMFDEQNI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 160 LYSLIFSVLAMLLGMLLKPSVMPQGEARTHSDTERSLW-ALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEAGYSAS 238
Cdd:TIGR00902 161 LAILTAGLAFMLIGFLIKPTIPPKDAIPEDESQGDSAFiALLKNPMNLRFLAAVCLIQGAHAAYYGFSAIYWQAAGISAS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 239 TIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAA 318
Cdd:TIGR00902 241 ATGLLWGIGVLAEIIIFAFSNKLFQNCSARDLLLISAIACVGRWAIIGAIEAFPLIFLLQILHCGTFAVCHLAAMRYIAA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 644363006 319 RQGQEVIRLQAVYSALAMGGGIAVMTVIAGFLFEHWQGGVFWVMAAVAVPALFIRPPAV 377
Cdd:TIGR00902 321 QPGSEIAKLQALYNALAMGGLIAIFTAFAGFIYPTLGAGTFVFMAIIAAAAFFLIPKKL 379
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
8-374 |
4.65e-81 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 252.50 E-value: 4.65e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 8 WLALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLLIAPRVKDPSHLVSALRLLALLTLAFAVGF 87
Cdd:cd17335 1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 88 CFGNG--WgWLMLVIAGFNLFFSPLVPLTDALAATWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAILY-SLI 164
Cdd:cd17335 81 FFVAQifW-LLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYKNYTiAFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 165 FSVLAMLLGMLLKPSVMPQGEARTHSDTERSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEAGYSASTIGYLW 244
Cdd:cd17335 160 VFAVLMLLALLLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLW 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 245 SLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAARQGQEV 324
Cdd:cd17335 240 TVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 644363006 325 -IRLQAVYSALAMGGGIAVMTVIAGFLFEHWQGG----VFWVMAAVAVPALFIRP 374
Cdd:cd17335 320 rATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARttfrFFAIAALAGLLAFFLIQ 374
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
8-360 |
3.59e-49 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 169.73 E-value: 3.59e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 8 WLALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLL---IAPRVKDPSHLVSALRLLALLTLAFA 84
Cdd:pfam12832 3 RLKGFYFFYFAALGCLLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIwgwLADRTGKRKAVVRLASILAAVLFLSV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 85 VGFCFGNGWGWLMLVIAGFNLFFSPLVPLTDALAATWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAILYSLI 164
Cdd:pfam12832 83 LFIPISLTFWWLALLVVLFSFFWNAILPQFEVATLQHLGEKRKDYGRQRLWGSVGFALSVFGLGALFDHYSVGLLPSVLF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 165 FSVLAMLLGMLLKPSVMPQGEARTHSDTERSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEAGYSASTIGYLW 244
Cdd:pfam12832 163 YLFAALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGASNTLLGALW 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 245 SLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLL-IQILHCGTFTVCHLAAMRFIAARQGQE 323
Cdd:pfam12832 243 ALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLYAFFVENPWLVLpIQFLHAISFGLTHAAAIEYVRRIFPGS 322
|
330 340 350
....*....|....*....|....*....|....*...
gi 644363006 324 VI-RLQAVYSALAMGGGIAVMTVIAGFLFEHWQGGVFW 360
Cdd:pfam12832 323 LQgTGQALYSGLYFGLGGALGSLIGGQLWDLFGARFTF 360
|
|
| mfs |
NF037955 |
MFS transporter; |
9-370 |
1.17e-36 |
|
MFS transporter;
Pssm-ID: 411561 [Multi-domain] Cd Length: 366 Bit Score: 136.32 E-value: 1.17e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 9 LALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSlliAPRVKDPSHLVSALRLLALLTLAFAVGFC 88
Cdd:NF037955 2 LSLLYAVVFVEIGIAMPFMPVWLEALGLDAGVIGLLLALPIAVRIVAT---APLMSLIDRGVGARRLLLAGSLGLALTYA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 89 F-----GNGWGWLMLVIAGFNLFFSPLVPLTDALA-ATWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHN-AILY 161
Cdd:NF037955 79 LmpaaaALGWPLLALLVALNAVAQAPLVPSIDYLTlAAVRRDPRLDYARIRMSGSVAFLAANLAGGALLGALGERvAVPL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 162 SLIFSVLAMLLGMLLKPSVMPQGEARTHSDTERSLWALLkegpvWRFLLCVTLLQGAHAGYYSFGSIYWQEAGYSASTIG 241
Cdd:NF037955 159 LLTGLALVAALVALASRVRAAAAPPRPREAGRPRLPRVL-----WLAIAAGAAIQASHAAIYAFGSIHWRAHGISTAWIG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 242 YLWSLGVVAEVIIFASSNVLFRRWNA-RNLLLLSACCGVLRWSLMA-YSTELGWLLLIQILHCGTFTVCHLAAMRFIAAR 319
Cdd:NF037955 234 ALWAIGVVAEIVLFALLGRLPARWRTpFRLLGLGAAAALVRAIGMAlLGGTLAAVVPLQALHGLTFGATQLGAMAAVSAF 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 644363006 320 QGQEVI-RLQAVYSAlAMGGGIAVMTVIAGFLFEHWQGGVFWVMAAVAVPAL 370
Cdd:NF037955 314 APEGARgRAQGTYSA-ANALASASATLASGLAYRAGGPLAFALMAPLALIGL 364
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
9-372 |
4.34e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.83 E-value: 4.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 9 LALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLLIApRVKDPSHLVSALRLLALLTLAFAVGFC 88
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAG-RLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 89 FGNGWGWLMLVIAGFNLFFSPLVPLTDALAA--TWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAILY-SLIF 165
Cdd:cd17325 80 FATSYWQLLLARFLQGLASAAVWPAAMALIAdiAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLvCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 166 SVLAMLLGMLLKPSVMPQGEARTHSDTE--RSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQE-AGYSASTIGY 242
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARlrSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAElGGLSPAQIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 243 LWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAARQGQ 322
Cdd:cd17325 240 LFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 644363006 323 EviRLQAVYSALAMGGGIAVMT--VIAGFLFEHWQ-GGVFWVMAAVAVPALFI 372
Cdd:cd17325 320 E--GRGTAMGLFNTAFSLGMVLgpLLGGFLYDAFGfATPFLAAAALLLLAAVL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-339 |
7.13e-12 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.77 E-value: 7.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 9 LALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLlIAPRVKDPSHLVSALRLLALLTLAFAVGFC 88
Cdd:COG2814 15 LALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAP-LAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 89 FGNGWGWLMLVIAGFNLFFSPLVPLTDALAATW--QKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAILYSLIFS 166
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAGALFPAALALIADLvpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 167 VLAMLLGMLLkpsVMPQGEARTHSDTERSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQE-AGYSASTIGYLWS 245
Cdd:COG2814 174 ALLALLLLLR---LLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 246 LGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAARQGQEVI 325
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR 330
|
330
....*....|....*
gi 644363006 326 -RLQAVYSALAMGGG 339
Cdd:COG2814 331 gRASGLYNSAFFLGG 345
|
|
| MFS_NHS |
cd06177 |
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The ... |
95-301 |
2.38e-10 |
|
Nucleoside:H(+) symporter family of the Major Facilitator Superfamily of transporters; The prototypical members of the Nucleoside:H(+) symporter (NHS) family are Escherichia coli nucleoside permease NupG and xanthosine permease. Nucleoside:H(+) symporters are proton-driven transporters that facilitate the import of nucleosides across the cytoplasmic membrane. NupG is a broad-specificity transporter of purine and pyrimidine nucleosides. Xanthosine permease is involved in the uptake of xanthosine and other nucleosides such as inosine, adenosine, cytidine, uridine and thymidine. The NHS family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340866 [Multi-domain] Cd Length: 386 Bit Score: 61.49 E-value: 2.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 95 WLMLViagFNLFFSPLVPLTDALAATWQKQIRMDYGRVRLWGSLAFvIGSALTGQLVAVWGHNAILY-----SLIFSVLA 169
Cdd:cd06177 92 WVMLL---YSLCYMPTLALTNSIAFSNLEDPVKDFPPIRVWGTIGW-IAAGWPVGFLGWEASNLQFYiaagaSLLLGLYS 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 170 MLLgmllkPSVMPQGEARThSDTERSLW----ALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEAGYSASTIGYLWS 245
Cdd:cd06177 168 LTL-----PHTPPKKAGKG-VSKRSLLGldafVLLKNPFFAVFFIFSFLLGAPLQFYYTFANPFLNDFGMIVKNPAGIMS 241
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 644363006 246 LGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAY---STELGWLLLIQILH 301
Cdd:cd06177 242 LGQISEILFMLAIPFFLKRLGIKKVMLIGMLAWVLRFGLFAYgdpSPGVWMLVLSIILH 300
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
137-372 |
7.10e-09 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 56.79 E-value: 7.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 137 SLAFVIGSALTGQLVAVWGHNAILY-SLIFSVLAMLLGMLLKPSVMPQgeaRTHSDTERSLWALLKEGPVWRFLLCVTLL 215
Cdd:cd17471 135 SLAWVIGPPLAFLLLDVLGFTGLFLlAALLYLVVALLVLFLLPSVKPP---AQKATPASSLVKAPVNRRLLLLFAAFTLL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 216 QGAHAGYYSFGSIYW-QEAGYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWL 294
Cdd:cd17471 212 FAANSMYIIAMPLYVtNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQL 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 295 LLIQILHCGTFTVCHLAAMRFIaarqgQEVIRLQAVY-SAL---AMGGGIAVMTVIAGFLFEHW-QGGVFWVMAAVAVPA 369
Cdd:cd17471 292 IALQLLNAIFIGITAGLGISYF-----QDLMPGQPGLaTTLysnASRIGSLLGGLLAGVIAQYFgYRAVFLVCAVLALLA 366
|
...
gi 644363006 370 LFI 372
Cdd:cd17471 367 LVL 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-365 |
1.15e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 56.08 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 7 RWLALSYFTYFFSYGIFLPFWGVWLKGE-GIAPETIGILLGAGLVARFLGSLlIAPRVKDPSHLVSALRLLALLTLAFAV 85
Cdd:cd17329 2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQlGLSASIVGLVLALSAVAGIVASL-IGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 86 GFCFGNGWGWLMLVIAGFNLFFSPLVPLTDALAA--TWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAILYSL 163
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIAdvTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 164 IFSVLAMLLGMLLKPSVMPQGEARTHSDTERSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEA-GYSASTIGY 242
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEIlGLGESLLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 243 LWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILhcgtFTVCHL----AAMRFIAA 318
Cdd:cd17329 241 LLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIV----LTLGEMlvfpAVQTLVAA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 644363006 319 RQGQEVIRLQAVYSALAMGGGIAVMTVIAGFLFEHWQGGVFWVMAAV 365
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAA 363
|
|
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
10-353 |
2.01e-08 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 55.54 E-value: 2.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 10 ALSYFTYFFSYGIFLPFWGVWLKG-EGIAPETIGIL-----LGAGLVARFLGslLIAPRVKDPSHLVSALRLLALLTLAF 83
Cdd:pfam01306 13 GLFFFFYFFIMSAYFPFFPIWLHDvNHLSKTDTGIVfscisLFSILFQPLFG--LISDKLGLRKHLLWCITGLLVLFAPF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 84 AVgFCFG-----NGWGWLMLVIAGFNLFFSPLVPLTDALAATWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNA 158
Cdd:pfam01306 91 FI-YVFGpllqsNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGILFSIDPQIV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 159 ILYSLIFSVLAMLLGMLLKPS------VMPQGEARTHSDTERSLWALLKEGPVWRFLLCVTllqgahaGYYSFGSIYWQE 232
Cdd:pfam01306 170 FWLGSGFALILALLLMFAKPDksssaiVADALGANKSAFSLRLALELFRMPKFWVFVLYVV-------GVACVYDVFDQQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 233 -----AGYSAS------TIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILH 301
Cdd:pfam01306 243 fanffTSFFATpqqgtrVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKMLH 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 644363006 302 CGTFTVCHLAAMRFIAArqgQEVIRLQA----VYSALAMGGGIAVMTVIAGFLFEH 353
Cdd:pfam01306 323 MFEVPFLLVGCFKYITS---QFDVRLSAtiylIGFQFSKQLAMILLSTLAGIMYDS 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
137-372 |
5.75e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.09 E-value: 5.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 137 SLAFVIGSALTGQLVAVWGHNAILYSL-IFSVLAMLLGMLLKPSVmpQGEARTHSDTERSLWALLKEGPVWRFLLCVTLL 215
Cdd:cd17324 133 TLGLVLGRPLGGLLGQLLGWRAAFLAIaVLALLAALLLWRLLPSL--PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 216 QGAHAGYYSF-GSIYWQEAGYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWL 294
Cdd:cd17324 211 FGGFFALYTYlAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLL 290
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 644363006 295 LLIQILHCGTFTVCHLAAMRFIAARQGQEVIRLQAVYSAlAMGGGIAVMTVIAGFLFEHWQ-GGVFWVMAAVAVPALFI 372
Cdd:cd17324 291 LVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLA-AYNLGGALGAALGGLVLDHGGwAGVGWVGAALLLLALLL 368
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
137-371 |
9.13e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.35 E-value: 9.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 137 SLAFVIGSALTGQLVAVWGHNAILYSL-IFSVLAMLLGMLLKPSVMPQGEARTH-SDTERSLWALLKEGPVWRFLLCVTL 214
Cdd:cd17320 133 AIAPALAPLLGGLLLLFFGWRAIFVFLaLLGLLLLLLVLLFLPETLPEEKRKPLlSSLLRAYKRVLKNRRFLGYALALGL 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 215 LQGAHAGYYSFGS-IYWQEAGYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELG- 292
Cdd:cd17320 213 SFAGLFAYLAAAPfIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGg 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 293 ----WLLLIQILHCGTFTVCHLAAMRFIAARQGQEVIRLQAVYSALAMGGGiAVMTVIAGFLFEHWQGGVFWVMAAVAVP 368
Cdd:cd17320 293 lslwPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIG-ALAGALVGLLPNGTALPMGLLILVLGLL 371
|
...
gi 644363006 369 ALF 371
Cdd:cd17320 372 ALL 374
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
126-353 |
1.19e-07 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 53.01 E-value: 1.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 126 RMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAILYSLIFSVLAMLLGMLLKPSVMPQGEARTHSDTERSL---WALLKE 202
Cdd:cd06172 129 NFEYGRARMWGSLGWALAAFFAGILFNINPNINFWLGSGFALILLLLLLFAKPEDSDTAAAAGANASSVSLkdvLELFRM 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 203 GPVWRFLLCVtllqgahAGYYSFGSIYWQE-AGYSAS----------TIGYLWSLGVVAEVIIFASSNVLFRRWNARNLL 271
Cdd:cd06172 209 PKFWFFILFV-------IGVSCFYDVFDQQfPPYFTSlfatpeqgnrVFGYLNSAQVFLEAGMMFLAPLIVNRIGAKNGL 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 272 LLSACCGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAarqGQEVIRLQA----VYSALAMGGGIAVMTVIA 347
Cdd:cd06172 282 LLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLVSIFKYIT---SHFDTRLSAtlylVGFQFAKQLGAVVLSPLA 358
|
....*.
gi 644363006 348 GFLFEH 353
Cdd:cd06172 359 GNLYDS 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-300 |
1.47e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 9 LALSYFTYFFSYGIFLPFWGVWLKGE-GIAPETIGILLGAGLVARFLGSLLIAPRVKDPSHLVSALRLLALLTLAFAVGF 87
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 88 cFGNGWGWLMLVIAGFNLFFSPLVPLTDALAATW--QKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWGHNAILYSLIF 165
Cdd:pfam07690 81 -FASSLWLLLVLRVLQGLGAGALFPAALALIADWfpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 166 SVLAMLLGMLL---KPSVMPQGEARTHSDTERSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEAGYSASTIGY 242
Cdd:pfam07690 160 LSLLAAVLLLLprpPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGL 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 644363006 243 LWSLGVVAEVIIFASSNVLFRRWNARNLLL---LSACCGVLRWSLMAYSTELGWLLLIQIL 300
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLlalLLLILAALGLLLLSLTLSSLWLLLALLL 300
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-372 |
1.72e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.35 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 9 LALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLLIAPRVkDPSHLVSALRLLALLTLAFAVGFC 88
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLA-DRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 89 FGNGWGWLMLVIAGFNLFFSPLVPLTDALAATWQKQIRMD--YGRVRLWGSLAFVIGSALTGQLV--AVWGHNAILYSLI 164
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGraLGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 165 FSVLAMLLGMLLKPSVMP-----QGEARTHSDTERSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYW-QEAGYSAS 238
Cdd:cd06174 160 ALALLAAILLLLVVPDPPesaraKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLlDLGGLSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 239 TIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSAC-CGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIA 317
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLlLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 644363006 318 ARQGQEVIRLQAVYSALAMGGGIAVMTVIAGFLFEHWQG--GVFWVMAAVAVPALFI 372
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGltGAFLVLAVLLLLAAIL 376
|
|
| lacY |
PRK09528 |
galactoside permease; Reviewed |
129-372 |
3.51e-06 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 48.74 E-value: 3.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 129 YGRVRLWGSLAFVIGSALTGQLVAVWGHNAILYSLIFSVLAMLLGMLLKPS------VMPQGEARTHSDTERSLWALLKE 202
Cdd:PRK09528 143 YGRARMWGSLGWALCAFIAGILFNINPQINFWLGSGSALILLVLLFFAKPDapstakVANALGANASAVSLKDALALLKL 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 203 GPVWRFLLCVTllqgahaGYYSFGSIYWQE-AGYSAS----------TIGYLWSLGVVAEVIIFASSNVLFRRWNARNLL 271
Cdd:PRK09528 223 PKFWFLVLYVI-------GVACFYDVFDQQfPNFFASffatpeqgtrVFGYLNSFQVFLEALIMFFAPFIINRIGAKNAL 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 272 LLSACCGVLRWSLMAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAARQGQeviRLQA----VYSALAMGGGIAVMTVIA 347
Cdd:PRK09528 296 LLAGTIMAVRIIGSGFATGPLEVSILKLLHAFEVPFLLVGVFKYITLNFDV---RLSAtiylVGFQFAKQLGAVFLSTLA 372
|
250 260
....*....|....*....|....*.
gi 644363006 348 GFLFEHWQ-GGVFWVMAAVAVPALFI 372
Cdd:PRK09528 373 GNLYDSIGfQGTYLILGGIVLLFTLI 398
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
7-353 |
4.07e-06 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 48.59 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 7 RWLALSYFTYFFSYGIFLPFWGVWLKG-EGIAPETIGIL-----LGAGLVARFLGslLIAPRVKDPSHLVSALRLLALLT 80
Cdd:TIGR00882 5 WMFGLFFFLYFFIMSAYFPFFPIWLHDvNGLSKTDTGIVfscisLFSILFQPLFG--LISDKLGLKKHLLWIISGLLVLF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 81 LAFAVgFCFG-----NGWGWLMLVIAGFNLFFSPLVPLTDALAATWQKQIRMDYGRVRLWGSLAFVIGSALTGQLVAVWG 155
Cdd:TIGR00882 83 APFFI-YVFGpllqsNILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSIDP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 156 HNAILYSLIFSVLAMLLGMLLKPSVMPQGE------ARTHSDTERSLWALLKEGPVWRFLLCVTllqgahaGYYSFGSIY 229
Cdd:TIGR00882 162 QIVFWLGSGFALILMLLLMFAKPKAPSSATvanalgANASAFSLKLALELFRQRKFWMFVLYVV-------GVACVYDVF 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 230 WQE-----AGYSAS------TIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQ 298
Cdd:TIGR00882 235 DQQfanffTSFFATpqqgtrVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILK 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 644363006 299 ILHCGTFTVCHLAAMRFIAarqGQEVIRLQA----VYSALAMGGGIAVMTVIAGFLFEH 353
Cdd:TIGR00882 315 MLHAFEVPFLLVGCFKYIT---SQFDVRLSAtiylIGFQFAKQLAMIFLSTLAGNMYDS 370
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
9-372 |
4.78e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.99 E-value: 4.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 9 LALSYFTYFFSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSL---LIAPRVkdPSHLVSALRLLALLTLAFAV 85
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIplgILSDRI--GKRKLFIIIGLLFTVLASLI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 86 GFCFGNGWGWLMLVIAG---------FNLFFSPLVPLTDALAATwqkqirmdyGRVRLWGSLAFVIGSALTGQLVAVWGH 156
Cdd:cd17490 79 MILFPSPWGLLIARFLSgiaaatwvsFTVLYASYFPPDEAAKAM---------GLINLVNNLGQLIAFLIGGLIAEHFGM 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 157 NAILY-SLIFSVLAMLLGMLLKPSVMPQGEARTHSdteRSLWALLKEGPVWRF-LLCVTLLQGAHAGYYSFGSIYWQEAG 234
Cdd:cd17490 150 RAPFLlAALAGVLGFILSLFIKEERREKKPVLTEL---KELLSVLKDKKLLFFsLLAILQQMITFSTTFGFTPLIAKQLG 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 235 YSASTIGYLWSLGVVAEVI-IFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLIQILH-CGT---FTVCH 309
Cdd:cd17490 227 ASSFQLGLLSIIYLLPNALaSLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNgFGTgilFPLLM 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 644363006 310 LAAMRFIAARQGQEVIRL-QAVYSAlamggGIAVMTVIAGFLFEHWQ-GGVFWVMAAVAVPALFI 372
Cdd:cd17490 307 SLSIEGVPAEQRSTAMGFfQAIYAL-----GMFLGPVLVGIISEAFGlQTGFFVIGVIALLAAIL 366
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
18-297 |
6.16e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 6.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 18 FSYGIFLPFWGVWLKGEGIAPETIGILLGAGLVARFLGSLLIAPRVKDPSHLVSALRLLALLTLAFAVGFCFGNGWGWLM 97
Cdd:cd17477 10 LGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 98 L-VIAGFNLFFSpLVPLTDALAATWQKQIRmdyGRVRLWGSLAFVIGSALtGQLVAVWGHNAILYSLIFSVLAMLLGMLL 176
Cdd:cd17477 90 LrFVMGIGLAGL-FVVSESWLNALATNENR---GRVLGLYSTVLGLGFAL-GPLLLALVGTAGALPFLIAAVLLLLALVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 177 kPSVMPQGEARTHSDTERSLWALLKEGPVwrfLLCVTLLQG-AHAGYYSFGSIYWQEAGYSASTIGYLWSLGVVAEVIIF 255
Cdd:cd17477 165 -LLLTRRAAPEIEEAESISLRRLLRIAPL---ALLGAFVAGfLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQ 240
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 644363006 256 ASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELGWLLLI 297
Cdd:cd17477 241 WPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLV 282
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
137-372 |
1.10e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.07 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 137 SLAFVIGSALTGQLVAVWGHNAILYS-LIFSVLAMLLGMLLKPSVMPQGEARTH--SDTERSLWALLKEGPVWRFLLCVT 213
Cdd:COG0738 141 SLGALLGPLLGGLLILLGLSLSWHLPyLILAVLLLLLALLFLRSKLPEIEEEEEeaAGSAASLKSLLKNPRLLLGGLAIF 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 214 LLQGAHAGYYSFGSIYWQEA-GYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELG 292
Cdd:COG0738 221 LYVGAEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPW 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 293 WLLLIQILHCGTFTVCHLAAMRFIAARQGQEVIRLQAVYSALAMGGGiAVMTVIAGFLFEHWqgGVFWVMAAVAVPALFI 372
Cdd:COG0738 301 LALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGG-AIGPPLIGFLADAF--GLRAAFLVPLVCYLLI 377
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
137-372 |
1.19e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 137 SLAFVIGSALTGQLVAVWG-HNAILYSLIFSVLAMLLGMLLkpsVMPQGEARTHSDTERSLWALLKEGPVWRFLLCVTLL 215
Cdd:COG2807 151 GLGAALAAGLTVPLAAALGwRGALAVWALLALLALLLWLPL---LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQ 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 216 QGAHAGYYSFGSIYWQEAGYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSAC----CGVLRWSLMAYSTEL 291
Cdd:COG2807 228 SLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGllglAGLLGLLLAPGSLPW 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 292 GWLLLIQILHCGTFTVC-HLAAMRFiaaRQGQEVIRLqavySALAMGGGI---AVMTVIAGFLFEHWQG--GVFWVMAAV 365
Cdd:COG2807 308 LWAVLLGLGQGGLFPLAlTLIGLRA---RTPAEAAAL----SGMAQSVGYllaALGPLLVGALHDATGSwtAALLLLAAL 380
|
....*..
gi 644363006 366 AVPALFI 372
Cdd:COG2807 381 AVLMLVA 387
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
134-372 |
3.35e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.16 E-value: 3.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 134 LWGSLAFVIGSALTGQLVAVWGHNAILYSLIFSVLAMLLGMLLKPSVMPQGEARTHSDTERSLWALLKEGPVWRFLLCVT 213
Cdd:cd17478 126 VGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVF 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 214 LLQGAHAGYYSFGSIYWQEAGYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTELG- 292
Cdd:cd17478 206 LRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWs 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 293 --WLLLIQILHCGTFTVCHLAAMRFIAARQGqevirlqaVYSALAMG---GGIAVMTVIAGFLFEHWQGG-VFWVMAAVA 366
Cdd:cd17478 286 yiLLVLAGFLLFASFPVTVVLAQELLPGNVG--------LASGLMMGlsfGLGGIGAPVLGALADAFGLEsVLLILALLP 357
|
....*.
gi 644363006 367 VPALFI 372
Cdd:cd17478 358 LLGALL 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
130-372 |
4.93e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.79 E-value: 4.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 130 GRVRLWGSLAFVIGSALTGQLVAVWG-HNAILYSLIFSVLAMLLGMLLKPSVmPQGEARTHSDTERSLWALLKEGPVWRF 208
Cdd:COG2223 132 GLAAGGGNLGAAVAAFLAPLLIAAFGwRNAFLILGILLLVVAVLAWLFLRDP-PAGAAAAAKASLRDQLEALRDPRFWLL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 209 LLCVTLLQGAHAGYYSFGSIYWQEA-GYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAY 287
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLAL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 288 STELGWLLLIQILHCGTFTVCHLAAM-RFIAARQGQEviRLQAVYSALAMGGGIA--VMTVIAGFLFEHWQG--GVFWVM 362
Cdd:COG2223 291 ALGSLWLFLVLFLLLGLALGGGNGAVfALVPDIFPTK--NAGAVYGLVGAAGGLGgfLGPLLFGALLDATGSytAAFLVF 368
|
250
....*....|
gi 644363006 363 AAVAVPALFI 372
Cdd:COG2223 369 AVLALVALVL 378
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
138-365 |
2.14e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.93 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 138 LAFVIGSALTGQLVAVWGHNAILYSLIFSVLAMLLGMLLKPSVMPQGEARTHSDTE----RSLWALLKEGPVWRFLLCVT 213
Cdd:cd17388 137 LGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRanpfGSLRWLTGFPGLLGLLAVFF 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 214 LLQGAHAGYYSFGSIYWQEA-GYSASTIGY-LWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYSTEL 291
Cdd:cd17388 217 LIQLIGQVPATTWVLFTEDRfDWSPTMVGLsLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQG 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 292 GWLLLIQILHC-GTFTVCHLAAM---RFIAARQGQevirLQAVYSALAMGGGIA---VMTVIAGFLFEHWQGGVfWVMAA 364
Cdd:cd17388 297 WMVFPILILLAlGGIAGPALQGLlsrQVPENEQGE----LQGVLTSLTSLTSIIgplLFTGIFAASPATWPGLA-WIIGA 371
|
.
gi 644363006 365 V 365
Cdd:cd17388 372 A 372
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
93-300 |
5.18e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.73 E-value: 5.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 93 WGWLMLVIAGFNLFFS----PLVPLTDALAATWQKQIRMdYGRVRLWGSLAFVIGSALTGQLVAVWGHN--------AIL 160
Cdd:COG2211 110 LIYALVTYLLLGLAYTlvniPYSALGAELTPDYEERTRL-SSWRFAFAGLGGLLASVLPPPLVAAFGGDaalgyrltALI 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 161 YSLIFSVLAMLLGMLLKPSVMPQGEARTHSDterSLWALLKEGPVWRFLLCVTLLQGAHAGYYSFGSIYWQEA-GYSAST 239
Cdd:COG2211 189 FAVLGLLAFLLTFFGTKERPVPEEEKVSLKE---SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAAL 265
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 644363006 240 IGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSLMAYS--TELGWLLLIQIL 300
Cdd:COG2211 266 VGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAAL 328
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
130-372 |
8.79e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 37.98 E-value: 8.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 130 GRVRLWGSLAFVIGSALTGQLVAVWGHNAILY----SLIFSVLAMLLGMLLKPSVMPQGEARTHSDTERSLWALLKEGPV 205
Cdd:cd06173 131 ALNSLATQLARIIGPALGGLLVALLGPGGAFAinalSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 206 WRFLLCVTLLQGAHAGYYSFGSIYWQEA-GYSASTIGYLWSLGVVAEVIIFASSNVLFRRWNARNLLLLSACCGVLRWSL 284
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644363006 285 MAYSTELGWLLLIQILHCGTFTVCHLAAMRFIAARQGQEVI-RLQAVYSALAMgGGIAVMTVIAGFLFEHWQG-GVFWVM 362
Cdd:cd06173 291 LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgRVFSVYNALNS-GAMPLGALLAGLLADALGLsAVFLLA 369
|
250
....*....|
gi 644363006 363 AAVAVPALFI 372
Cdd:cd06173 370 GALLLLAALL 379
|
|
| |
