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Conserved domains on  [gi|644366275|ref|WP_025304489|]
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MULTISPECIES: type I DNA topoisomerase [Serratia]

Protein Classification

type I DNA topoisomerase( domain architecture ID 11425664)

DNA topoisomerase I is a type IA DNA topoisomerase that releases the supercoiling and torsional tension of DNA, which is introduced during DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex

EC:  5.6.2.1
Gene Ontology:  GO:0003917
PubMed:  19208647

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 54-175 6.27e-51

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


:

Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 173.51  E-value: 6.27e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  54 HIVKVLDGQPCPKCQATLVLRQGRYGMFIGCSDYPQCDHTEVIDKPDETAITCPQCGqGKLLQRKSRYGKVFHSCDRYPE 133
Cdd:COG0551  579 SEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNYPECKYTKPLPKPEVTGVKCPKCG-KKLVLRKSKKGKVFYGCSNYPK 657

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 644366275 134 CQFALNVKPVAGECAYCHYPLLmEKRTAKGpvlcCASKLCGK 175
Cdd:COG0551  658 CKFTEWDKPVKEPCPKCGSPLV-EKKTKKG----CANKLCGY 694
YrdD super family cl33943
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 12-92 4.93e-15

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0551:

Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 72.20  E-value: 4.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  12 NEPCPECGAELVIRSGRHG-PFLGCSQYPECQYIRPLKAQADghivkvldgqPCPKCQATLVLRQGRYgmfiGCSDYpQC 90
Cdd:COG0551  628 GVKCPKCGKKLVLRKSKKGkVFYGCSNYPKCKFTEWDKPVKE----------PCPKCGSPLVEKKTKK----GCANK-LC 692


                 ..
gi 644366275  91 DH 92
Cdd:COG0551  693 GY 694
 
Name Accession Description Interval E-value
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 54-175 6.27e-51

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 173.51  E-value: 6.27e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  54 HIVKVLDGQPCPKCQATLVLRQGRYGMFIGCSDYPQCDHTEVIDKPDETAITCPQCGqGKLLQRKSRYGKVFHSCDRYPE 133
Cdd:COG0551  579 SEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNYPECKYTKPLPKPEVTGVKCPKCG-KKLVLRKSKKGKVFYGCSNYPK 657

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 644366275 134 CQFALNVKPVAGECAYCHYPLLmEKRTAKGpvlcCASKLCGK 175
Cdd:COG0551  658 CKFTEWDKPVKEPCPKCGSPLV-EKKTKKG----CANKLCGY 694
PRK06599 PRK06599
DNA topoisomerase I; Validated
 12-99 1.09e-31

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 119.96  E-value: 1.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  12 NEPCPEC-GAELVIRSGRHGPFLGCSQYPECQYIRPLKAQADG--HIVKVLDGQPCPKCQATLVLRQGRYGMFIGCSDYP 88
Cdd:PRK06599 585 DETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNITRDEDEpiEEEEIVEEEKCPKCGGPLVLKKGRYGKFLACSGYP 664

                         90
                 ....*....|.
gi 644366275  89 QCDHTEVIDKP 99
Cdd:PRK06599 665 ECKHIKPLEKP 675
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 12-92 4.93e-15

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 72.20  E-value: 4.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  12 NEPCPECGAELVIRSGRHG-PFLGCSQYPECQYIRPLKAQADghivkvldgqPCPKCQATLVLRQGRYgmfiGCSDYpQC 90
Cdd:COG0551  628 GVKCPKCGKKLVLRKSKKGkVFYGCSNYPKCKFTEWDKPVKE----------PCPKCGSPLVEKKTKK----GCANK-LC 692


                 ..
gi 644366275  91 DH 92
Cdd:COG0551  693 GY 694
PRK06599 PRK06599
DNA topoisomerase I; Validated
 5-48 1.32e-13

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 67.96  E-value: 1.32e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 644366275   5 AIFAARQNEPCPECGAELVIRSGRHGPFLGCSQYPECQYIRPLK 48
Cdd:PRK06599 630 EEEEIVEEEKCPKCGGPLVLKKGRYGKFLACSGYPECKHIKPLE 673
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
15-48 4.20e-10

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 52.65  E-value: 4.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 644366275   15 CPECGAELVIRSGRHGPFLGCSQYPECQYIRPLK 48
Cdd:pfam01396   4 CPKCGGDLVLKRGRFGKFVGCSNYPECRFTRPLK 37
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
61-98 1.88e-09

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 50.72  E-value: 1.88e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 644366275   61 GQPCPKCQATLVLRQGRYGMFIGCSDYPQCDHTEVIDK 98
Cdd:pfam01396   1 GGKCPKCGGDLVLKRGRFGKFVGCSNYPECRFTRPLKK 38
topA_arch TIGR01057
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ...
 15-41 5.04e-05

DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273420 [Multi-domain]  Cd Length: 618  Bit Score: 42.89  E-value: 5.04e-05
                          10        20
                  ....*....|....*....|....*..
gi 644366275   15 CPECGAELVIRSGRHGPFLGCSQYPEC 41
Cdd:TIGR01057 592 CPKCGGKLVSKYAKKGRFVGCSNYPEC 618
topA_arch TIGR01057
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ...
 64-90 9.69e-04

DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273420 [Multi-domain]  Cd Length: 618  Bit Score: 39.04  E-value: 9.69e-04
                          10        20
                  ....*....|....*....|....*..
gi 644366275   64 CPKCQATLVLRQGRYGMFIGCSDYPQC 90
Cdd:TIGR01057 592 CPKCGGKLVSKYAKKGRFVGCSNYPEC 618
 
Name Accession Description Interval E-value
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 54-175 6.27e-51

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 173.51  E-value: 6.27e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  54 HIVKVLDGQPCPKCQATLVLRQGRYGMFIGCSDYPQCDHTEVIDKPDETAITCPQCGqGKLLQRKSRYGKVFHSCDRYPE 133
Cdd:COG0551  579 SEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNYPECKYTKPLPKPEVTGVKCPKCG-KKLVLRKSKKGKVFYGCSNYPK 657

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 644366275 134 CQFALNVKPVAGECAYCHYPLLmEKRTAKGpvlcCASKLCGK 175
Cdd:COG0551  658 CKFTEWDKPVKEPCPKCGSPLV-EKKTKKG----CANKLCGY 694
PRK06599 PRK06599
DNA topoisomerase I; Validated
 12-99 1.09e-31

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 119.96  E-value: 1.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  12 NEPCPEC-GAELVIRSGRHGPFLGCSQYPECQYIRPLKAQADG--HIVKVLDGQPCPKCQATLVLRQGRYGMFIGCSDYP 88
Cdd:PRK06599 585 DETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNITRDEDEpiEEEEIVEEEKCPKCGGPLVLKKGRYGKFLACSGYP 664

                         90
                 ....*....|.
gi 644366275  89 QCDHTEVIDKP 99
Cdd:PRK06599 665 ECKHIKPLEKP 675
PRK07219 PRK07219
DNA topoisomerase I; Validated
 14-173 4.08e-31

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 118.18  E-value: 4.08e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  14 PCPECGAELVIRSGRHGP-FLGCSQYPECQYIRPLKAQadGHIvKVLDgQPCPKCQATLV-LRQGRYGMFIGCsdyPQCD 91
Cdd:PRK07219 604 KCPECGGDLIIIRTDKGSrFVGCSGYPDCRNTFPLPST--GRI-KVLD-EVCEKCGLPVIkILRGKQTFVVGC---PDCE 676

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  92 HTEVIDKPDETAITCPQCGqGKLLQRKSRYGKvFHSCDRYPECQFAL------NVKPVAGECAYCHYPLLMEKRTAKGPV 165
Cdd:PRK07219 677 AEKEEEDPDEVIGPCPKCG-GELAIKQLKYGS-FLGCTNYPKCKYTLplprrgKITVTDEKCPECGLPLLRVKGGFGDEL 754


                 ....*...
gi 644366275 166 LCCASKLC 173
Cdd:PRK07219 755 GCCNNPKC 762
PRK06319 PRK06319
DNA topoisomerase I/SWI domain fusion protein; Validated
 15-139 1.65e-29

DNA topoisomerase I/SWI domain fusion protein; Validated


Pssm-ID: 235778 [Multi-domain]  Cd Length: 860  Bit Score: 113.76  E-value: 1.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  15 CPEC-GAELVIRSGRHGPFLGCSQYPECQYIRP---LKAQADGHIVKVLDGQPCPKCQATLVLRQGRYGMFIGCSDYPQC 90
Cdd:PRK06319 595 CPKChKGKLVKIWAKNRYFYGCSEYPECDYKTSeeeLTFNKEDYAEDTPWDSPCPLCGGEMKVRHGRFGTFLGCENYPEC 674

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 644366275  91 DHTEVIDKPDETA------ITCPQCG-QGKLLQRKSRYGKVFHSCDRYPECQFALN 139
Cdd:PRK06319 675 RGIINIHKKGEEGiepeetVPCPAIGcTGHIVKRRSRFNKMFYSCSEYPACSVIGN 730
PRK07219 PRK07219
DNA topoisomerase I; Validated
 14-98 6.72e-23

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 94.68  E-value: 6.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  14 PCPECGAELVIRSGRHGPFLGCSQYPECQYIRPLKAQADghiVKVLDGQpCPKCQATLVLRQGRYGMFIGCSDYPQCDHT 93
Cdd:PRK07219 690 PCPKCGGELAIKQLKYGSFLGCTNYPKCKYTLPLPRRGK---ITVTDEK-CPECGLPLLRVKGGFGDELGCCNNPKCNYT 765


                 ....*
gi 644366275  94 EVIDK 98
Cdd:PRK07219 766 EKQKK 770
PRK06599 PRK06599
DNA topoisomerase I; Validated
 49-142 1.49e-19

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 84.91  E-value: 1.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  49 AQADGHIVKVLDGQ-----PCPKC-QATLVLRQGRYGMFIGCSDYPQCDHTEVIDKPDETAI---------TCPQCGQGK 113
Cdd:PRK06599 568 EKVEEDVRTEKVTQeetdeTCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNITRDEDEPIeeeeiveeeKCPKCGGPL 647

                         90       100
                 ....*....|....*....|....*....
gi 644366275 114 LLqRKSRYGKvFHSCDRYPECQfalNVKP 142
Cdd:PRK06599 648 VL-KKGRYGK-FLACSGYPECK---HIKP 671
YrdD COG0551
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ...
 12-92 4.93e-15

DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];


Pssm-ID: 440317 [Multi-domain]  Cd Length: 695  Bit Score: 72.20  E-value: 4.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  12 NEPCPECGAELVIRSGRHG-PFLGCSQYPECQYIRPLKAQADghivkvldgqPCPKCQATLVLRQGRYgmfiGCSDYpQC 90
Cdd:COG0551  628 GVKCPKCGKKLVLRKSKKGkVFYGCSNYPKCKFTEWDKPVKE----------PCPKCGSPLVEKKTKK----GCANK-LC 692


                 ..
gi 644366275  91 DH 92
Cdd:COG0551  693 GY 694
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 12-134 3.18e-14

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 69.82  E-value: 3.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  12 NEPCPECGAELVIRSGRHGPFLGCSQY---PECQYIRPLKaqADGHIVKVLDGQPC--------PKCQATLVLRQGRYGM 80
Cdd:PRK07561 587 DRDCPTCGRGMGIRTGKTGVFLGCSGYalkERCKTTRNLT--PEEETLNVLEGEDAetralgadPECGTAMVLRSGRFGP 664

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644366275  81 FI--GCSD-----------YPQCDHTEV----IDKPDETaITCPQCGqGKLLQRKSRYGKVFhSCDR-YPEC 134
Cdd:PRK07561 665 YVqeGEGDkprrlslpkgnNPECVGLEIalglLSLPRPV-GEHPECG-SEIQAKIGRFGPYV-KCGGtYASL 733
PRK06599 PRK06599
DNA topoisomerase I; Validated
 5-48 1.32e-13

DNA topoisomerase I; Validated


Pssm-ID: 235840 [Multi-domain]  Cd Length: 675  Bit Score: 67.96  E-value: 1.32e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 644366275   5 AIFAARQNEPCPECGAELVIRSGRHGPFLGCSQYPECQYIRPLK 48
Cdd:PRK06599 630 EEEEIVEEEKCPKCGGPLVLKKGRYGKFLACSGYPECKHIKPLE 673
PRK07220 PRK07220
DNA topoisomerase I; Validated
 14-124 4.46e-12

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 63.62  E-value: 4.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  14 PCPECGAELVIRSGRHGP-FLGCSQYPECQYIRPLKAQadGHIVkVLDGQpCPKC--QATLVLRQGRYGMFIGCsdyPQC 90
Cdd:PRK07220 591 KCPLCGSDLMVRRSKRGSrFIGCEGYPECTFSLPLPKS--GQII-VTDKV-CEAHglNHIRIINGGKRPWDLGC---PQC 663

                         90       100       110
                 ....*....|....*....|....*....|....
gi 644366275  91 DHTEVIDKPDETAITCPQCGQGKLLQRKSRYGKV 124
Cdd:PRK07220 664 NFIEWQKKQKEEKAQQPKKEKPKSIKDIKGIGKK 697
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
15-48 4.20e-10

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 52.65  E-value: 4.20e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 644366275   15 CPECGAELVIRSGRHGPFLGCSQYPECQYIRPLK 48
Cdd:pfam01396   4 CPKCGGDLVLKRGRFGKFVGCSNYPECRFTRPLK 37
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
61-98 1.88e-09

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 50.72  E-value: 1.88e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 644366275   61 GQPCPKCQATLVLRQGRYGMFIGCSDYPQCDHTEVIDK 98
Cdd:pfam01396   1 GGKCPKCGGDLVLKRGRFGKFVGCSNYPECRFTRPLKK 38
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 14-84 2.20e-08

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 52.87  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  14 PCPECGAELVIRSGRHGPFLGC-SQYPECQ---------YIRPLKAQADGHI-------VKVLdgqPCPKCQATLVLRQG 76
Cdd:PRK07561 705 EHPECGSEIQAKIGRFGPYVKCgGTYASLKntrkvltigLNRAVELLAEPKRpkedpvpLPEL---GCPKSGAPFVLRDG 781


                 ....*...
gi 644366275  77 RYGMFIGC 84
Cdd:PRK07561 782 RYGPYVKH 789
PRK07561 PRK07561
DNA topoisomerase I subunit omega; Validated
 56-103 2.51e-08

DNA topoisomerase I subunit omega; Validated


Pssm-ID: 236048 [Multi-domain]  Cd Length: 859  Bit Score: 52.49  E-value: 2.51e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 644366275  56 VKVLDGQPCPKCQATLVLRQGRYGMFIGCSDY---PQCDHTEVIDKPDETA 103
Cdd:PRK07561 582 QMVITDRDCPTCGRGMGIRTGKTGVFLGCSGYalkERCKTTRNLTPEEETL 632
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
9-79 1.86e-07

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 50.20  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275   9 ARQNEPCPECGAELVIRSGRHGPFLGCSQY-------PECQYIRPL---------KAQADGhiVKVLdGQpCPKCQATLV 72
Cdd:COG1754  599 PREINSCPLGTGGLSLRVGRYGPFIECSNYeprrasiPECLAPDELtpekaeellEAPADG--PRVL-GT-DPETGKPIV 674


                 ....*..
gi 644366275  73 LRQGRYG 79
Cdd:COG1754  675 LKDGRFG 681
PRK07219 PRK07219
DNA topoisomerase I; Validated
 13-53 1.94e-07

DNA topoisomerase I; Validated


Pssm-ID: 235971 [Multi-domain]  Cd Length: 822  Bit Score: 50.00  E-value: 1.94e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 644366275  13 EPCPECGAELVIRSGRHGPFLGCSQYPECQYIRPLKAQADG 53
Cdd:PRK07219 734 EKCPECGLPLLRVKGGFGDELGCCNNPKCNYTEKQKKEKES 774
PRK14973 PRK14973
DNA topoisomerase I; Provisional
 14-118 2.39e-07

DNA topoisomerase I; Provisional


Pssm-ID: 184936 [Multi-domain]  Cd Length: 936  Bit Score: 49.85  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 644366275  14 PCPECGAELVIRSGRHGPFLGCSQYPECQYIRPLKAQADGHIVKVLDgqPCPKCQATLV--LRQGRYGMFIGCsdyPQCD 91
Cdd:PRK14973 590 PCPVCGKDLRIKHIGSSQFIGCSGYPDCTFNIGLPGTTWGWAIRTDE--VCPIHHLNHVrlIRKGARPWDIGC---PLCS 664

                         90       100       110
                 ....*....|....*....|....*....|
gi 644366275  92 HtevIDKPDETAITCP---QCGQGKLLQRK 118
Cdd:PRK14973 665 H---IESNTESLLLMPsmtEELLQKLNAVH 691
zf-C4_Topoisom pfam01396
Topoisomerase DNA binding C4 zinc finger;
104-142 3.34e-07

Topoisomerase DNA binding C4 zinc finger;


Pssm-ID: 307520 [Multi-domain]  Cd Length: 39  Bit Score: 44.94  E-value: 3.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 644366275  104 ITCPQCGqGKLLQRKSRYGKvFHSCDRYPECQFALNVKP 142
Cdd:pfam01396   2 GKCPKCG-GDLVLKRGRFGK-FVGCSNYPECRFTRPLKK 38
PRK07220 PRK07220
DNA topoisomerase I; Validated
 100-138 3.99e-06

DNA topoisomerase I; Validated


Pssm-ID: 180892 [Multi-domain]  Cd Length: 740  Bit Score: 45.90  E-value: 3.99e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 644366275 100 DETAITCPQCGQgKLLQRKSRYGKVFHSCDRYPECQFAL 138
Cdd:PRK07220 586 DKIIGKCPLCGS-DLMVRRSKRGSRFIGCEGYPECTFSL 623
PRK06319 PRK06319
DNA topoisomerase I/SWI domain fusion protein; Validated
 102-136 2.38e-05

DNA topoisomerase I/SWI domain fusion protein; Validated


Pssm-ID: 235778 [Multi-domain]  Cd Length: 860  Bit Score: 43.66  E-value: 2.38e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 644366275 102 TAITCPQCGQGKLLQ--RKSRYgkvFHSCDRYPECQF 136
Cdd:PRK06319 591 TEIDCPKCHKGKLVKiwAKNRY---FYGCSEYPECDY 624
PRK07726 PRK07726
DNA topoisomerase 3;
48-109 3.82e-05

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 43.23  E-value: 3.82e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 644366275  48 KAQADGHIVKVLDGQPCPKCQATLVLRQGRYGMFIGCSDYPqCDHTEVIDKPdeTAITCPQC 109
Cdd:PRK07726 597 KQSSEKYKFDNLTGPKCPDCGKPMLKVKGKNGKMLVCQDRE-CGKRKNVSKK--TNARCPNC 655
topA_arch TIGR01057
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ...
 15-41 5.04e-05

DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273420 [Multi-domain]  Cd Length: 618  Bit Score: 42.89  E-value: 5.04e-05
                          10        20
                  ....*....|....*....|....*..
gi 644366275   15 CPECGAELVIRSGRHGPFLGCSQYPEC 41
Cdd:TIGR01057 592 CPKCGGKLVSKYAKKGRFVGCSNYPEC 618
topA_arch TIGR01057
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ...
 64-90 9.69e-04

DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273420 [Multi-domain]  Cd Length: 618  Bit Score: 39.04  E-value: 9.69e-04
                          10        20
                  ....*....|....*....|....*..
gi 644366275   64 CPKCQATLVLRQGRYGMFIGCSDYPQC 90
Cdd:TIGR01057 592 CPKCGGKLVSKYAKKGRFVGCSNYPEC 618
PRK07726 PRK07726
DNA topoisomerase 3;
13-42 1.97e-03

DNA topoisomerase 3;


Pssm-ID: 236078 [Multi-domain]  Cd Length: 658  Bit Score: 37.84  E-value: 1.97e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 644366275  13 EPCPECGAELVIRSGRHGPFLGCSQYPECQ 42
Cdd:PRK07726 611 PKCPDCGKPMLKVKGKNGKMLVCQDRECGK 640
COG1754 COG1754
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
64-93 2.10e-03

Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];


Pssm-ID: 441360 [Multi-domain]  Cd Length: 892  Bit Score: 37.87  E-value: 2.10e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 644366275  64 CPKCQATLVLRQGRYGMFIGCSDY-------PQCDHT 93
Cdd:COG1754  605 CPLGTGGLSLRVGRYGPFIECSNYeprrasiPECLAP 641
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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