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Conserved domains on  [gi|647321352|ref|WP_025758580|]
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MULTISPECIES: methyl-accepting chemotaxis protein [Enterobacter]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 1003728)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MCP_signal super family cl46910
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 1-553 0e+00

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


The actual alignment was detected with superfamily member PRK15041:

Pssm-ID: 481250 [Multi-domain]  Cd Length: 554  Bit Score: 557.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15041   1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  81 PASLAAINKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15041  81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 161 DDMEAVYNRWRAENNTLLKAAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQE 240
Cdd:PRK15041 161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNS 320
Cdd:PRK15041 241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 321 DNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041 321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15041 401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 647321352 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLNgKEKAVAPRPTNVKT---PQLLRPATTSASADsNWETF 553
Cdd:PRK15041 481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ-QQQQQQRETSAVVKtvtPATPRKMAVADSGE-NWETF 554
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-553 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 557.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15041   1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  81 PASLAAINKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15041  81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 161 DDMEAVYNRWRAENNTLLKAAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQE 240
Cdd:PRK15041 161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNS 320
Cdd:PRK15041 241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 321 DNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041 321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15041 401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 647321352 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLNgKEKAVAPRPTNVKT---PQLLRPATTSASADsNWETF 553
Cdd:PRK15041 481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ-QQQQQQRETSAVVKtvtPATPRKMAVADSGE-NWETF 554
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
20-517 4.55e-98

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 307.72  E-value: 4.55e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  20 LLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPASLAAINKLLGTAGDSLA 99
Cdd:COG0840    8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 100 KAEAYNKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLK 179
Cdd:COG0840   88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 180 AAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEM 259
Cdd:COG0840  168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 260 QQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNSDNARQATLLAKNASETAAR 339
Cdd:COG0840  248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 340 GGHVVDNVVR--------------TMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRT 405
Cdd:COG0840  328 GGEVVEEAVEgieeiresveetaeTIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRK 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 406 LASRSAQAAKEIKGLIENSVSRVNT--------------GSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIE 471
Cdd:COG0840  408 LAERSAEATKEIEELIEEIQSETEEaveameegseeveeGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTE 487

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 647321352 472 QVSLAVSQMDSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRL 517
Cdd:COG0840  488 EVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 269-516 8.95e-71

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 227.55  E-value: 8.95e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   269 AVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVV 348
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   349 RTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIEN----- 423
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   424 ---------SVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQS 494
Cdd:smart00283 161 neavaameeSSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 647321352   495 ATAAAALEDQSEQLRQAVAAFR 516
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 296-495 1.23e-60

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 199.00  E-value: 1.23e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 296 EQQAASLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQT 375
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 376 NILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDI 455
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 647321352 456 MGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQSA 495
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 329-484 6.48e-59

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 193.42  E-value: 6.48e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  329 LAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLAS 408
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  409 RSAQAAKEIKGLI--------------ENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVS 474
Cdd:pfam00015  83 RSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162

                         170
                  ....*....|
gi 647321352  475 LAVSQMDSVT 484
Cdd:pfam00015 163 QAVARMDQVT 172
antiphage_ZorA_1 NF033914
anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel ...
 248-514 1.02e-06

anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel proteins, but it has been reported that they are also involved in anti-phage defense.


Pssm-ID: 411475 [Multi-domain]  Cd Length: 619  Bit Score: 51.53  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 248 EMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTeqqAASLEETA----ASMEELTATVKQNSD-- 321
Cdd:NF033914 291 ELRELAETLKQMQGSLVEMQGGLRGSGEDFARRMSEAAENLNRLVSDA---GSSLGDSAeqsrDALAEVVAALRQTFEka 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 322 NARQATLLAKNASETAAR----GGHVVDNVVRTMTEIADSSQqiahitgvidsiAFQTNilaLNAAVEAARAGEQgrgfA 397
Cdd:NF033914 368 NAEVDEALGAAAGGASGKleeaMGRVLEKLEAQIGGLGEGLG------------AFQGT---LAEQLDETREQIA----A 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 398 VVAGEVRTLASRSAQAAKEIKGLIENSVSRVNtgsEQVSEAGSTMKEIVAAVTRVTDIMGEISSasdeQSRgieQVSLAV 477
Cdd:NF033914 429 AQQSAAAAVASASAEAAEALRDGLADALATIR---AEIDRFEAAMRASEGALASQANAIGDATS----QTR---KVADAF 498

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 647321352 478 SQM-DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAA 514
Cdd:NF033914 499 SKTaQDVRAAAAPLAQSGERIAGATESMAESVGRTVEA 536
 
Name Accession Description Interval E-value
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
1-553 0e+00

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 557.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15041   1 MLKRIKIVTSLLLVLAVFGLLQLTSGGLFFNALKNDKENFTVLQTIRQQQSTLNGSWVALLQTRNTLNRAGIRYMMDQNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  81 PASLAAINKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15041  81 IGSGSTVAELMQSASISLKQAEKNWADYEALPRDPRQSTAAAAEIKRNYDIYHNALAELIQLLGAGKINEFFDQPTQGYQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 161 DDMEAVYNRWRAENNTLLKAAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQE 240
Cdd:PRK15041 161 DGFEKQYVAYMEQNDRLYDIAVSDNNASYSQAMWILVGVMIVVLAVIFAVWFGIKASLVAPMNRLIDSIRHIAGGDLVKP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNS 320
Cdd:PRK15041 241 IEVDGSNEMGQLAESLRHMQGELMRTVGDVRNGANAIYSGASEIATGNNDLSSRTEQQAASLEETAASMEQLTATVKQNA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 321 DNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15041 321 ENARQASHLALSASETAQRGGKVVDNVVQTMRDISTSSQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15041 401 GEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVESAGETMAEIVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEM 480

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 647321352 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLNgKEKAVAPRPTNVKT---PQLLRPATTSASADsNWETF 553
Cdd:PRK15041 481 DRVTQQNAALVEESAAAAAALEEQASRLTEAVAVFRIQ-QQQQQQRETSAVVKtvtPATPRKMAVADSGE-NWETF 554
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 1-553 0e+00

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 538.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRD 80
Cdd:PRK15048   1 MINRIRVVTLLVMVLGVFALLQLISGSLFFSSLHHSQKSFVVSNQLREQQGELTSTWDLMLQTRINLSRSAVRMMMDSSN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  81 PASlAAINKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAAlTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQ 160
Cdd:PRK15048  81 QQS-NAKVELLDSARKTLAQAATHYKKFKSMAPLPEMVAT-SRNIDEKYKNYYTALTELIDYLDYGNTGAYFAQPTQGMQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 161 DDMEAVYNRWRAENNTLLKAAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQE 240
Cdd:PRK15048 159 NAMGEAFAQYALSSEKLYRDIVTDNADDYRFAQWQLAVIALVVVLILLVAWYGIRRMLLTPLAKIIAHIREIAGGNLANT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 241 ITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNS 320
Cdd:PRK15048 239 LTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTREIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 321 DNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVA 400
Cdd:PRK15048 319 DNARQASQLAQSASDTAQHGGKVVDGVVKTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVA 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 401 GEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQM 480
Cdd:PRK15048 399 GEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVESAGETMNNIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEM 478

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 481 DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLngkekavAPRPTNVKTPQLLRPATTSASA---------DSNWE 551
Cdd:PRK15048 479 DRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRL-------AASPLTNKPQTPSRPASEQPPAqprlriaeqDPNWE 551


                 ..
gi 647321352 552 TF 553
Cdd:PRK15048 552 TF 553
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
1-525 7.51e-138

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 410.23  E-value: 7.51e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   1 MLKNLHVITGIIFALTIFCLLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTV----TRVAIRYLK 76
Cdd:PRK09793   1 MFNRIRISTTLFLILILCGILQIGSNGMSFWAFRDDLQRLNQVEQSNQQRAALAQTRAVMLQASTALnkagTLTALSYPA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  77 NQrdpaslaaINKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDA 156
Cdd:PRK09793  81 DD--------IKTLMTTARASLTQSTTLFKSFMAMTAGNEHVRALQKETEKSFARWHNDLEHQATWLESNQLSDFLTAPV 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 157 QQAQDDMEAVYNRWRAENNTLLKAAAEENQSSF--TQMQWTLAAILLAVIAVLVVIWQglQHLLLKPLNTIMNHIRAIAG 234
Cdd:PRK09793 153 QGSQNAFDVNFEAWQLEINHVLEAASAQSQRNYqiSALVFISMIIVAAIYISSALWWT--RKMIVQPLAIIGSHFDSIAA 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 235 GDLTQEITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTA 314
Cdd:PRK09793 231 GNLARPIAVYGRNEITAIFASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSSRTEQQAASLAQTAASMEQLTA 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 315 TVKQNSDNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGR 394
Cdd:PRK09793 311 TVGQNADNARQASELAKNAATTAQAGGVQVSTMTHTMQEIATSSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGR 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 395 GFAVVAGEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVS 474
Cdd:PRK09793 391 GFAVVAGEVRNLASRSAQAAKEIKGLIEESVNRVQQGSKLVNNAAATMTDIVSSVTRVNDIMGEIASASEEQRRGIEQVA 470

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 647321352 475 LAVSQMDSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRLNGKEKAVA 525
Cdd:PRK09793 471 QAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTLEEHEVARH 521
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
20-517 4.55e-98

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 307.72  E-value: 4.55e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  20 LLQVVTGGLFYSAVSNDRHNFQNSGVLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPASLAAINKLLGTAGDSLA 99
Cdd:COG0840    8 LALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVVLLALLLA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 100 KAEAYNKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLK 179
Cdd:COG0840   88 LLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAAAALAALL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 180 AAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEM 259
Cdd:COG0840  168 EAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDLTVRIDVDSKDEIGQLADAFNRM 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 260 QQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNSDNARQATLLAKNASETAAR 339
Cdd:COG0840  248 IENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELAEEASELAEE 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 340 GGHVVDNVVR--------------TMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRT 405
Cdd:COG0840  328 GGEVVEEAVEgieeiresveetaeTIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGFAVVADEVRK 407

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 406 LASRSAQAAKEIKGLIENSVSRVNT--------------GSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIE 471
Cdd:COG0840  408 LAERSAEATKEIEELIEEIQSETEEaveameegseeveeGVELVEEAGEALEEIVEAVEEVSDLIQEIAAASEEQSAGTE 487

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 647321352 472 QVSLAVSQMDSVTQQNAALVQQSATAAAALEDQSEQLRQAVAAFRL 517
Cdd:COG0840  488 EVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 269-516 8.95e-71

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 227.55  E-value: 8.95e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   269 AVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVV 348
Cdd:smart00283   1 DVSEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   349 RTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIEN----- 423
Cdd:smart00283  81 SAVEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEiqeet 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   424 ---------SVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQS 494
Cdd:smart00283 161 neavaameeSSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEI 240

                          250       260
                   ....*....|....*....|..
gi 647321352   495 ATAAAALEDQSEQLRQAVAAFR 516
Cdd:smart00283 241 SAAAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 296-495 1.23e-60

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 199.00  E-value: 1.23e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 296 EQQAASLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQT 375
Cdd:cd11386    1 EELSASIEEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 376 NILALNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDI 455
Cdd:cd11386   81 NLLALNAAIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 647321352 456 MGEISSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQSA 495
Cdd:cd11386  161 FEEIVASVEEVADGIQEISAATQEQSASTQEIAAAVEEIA 200
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 329-484 6.48e-59

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 193.42  E-value: 6.48e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  329 LAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRTLAS 408
Cdd:pfam00015   3 LAQLASEEAQDGGKEVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLAE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  409 RSAQAAKEIKGLI--------------ENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVS 474
Cdd:pfam00015  83 RSAQAAKEIEALIieiqkqtndstasiESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQEIAAASDEQSAGIDQVN 162

                         170
                  ....*....|
gi 647321352  475 LAVSQMDSVT 484
Cdd:pfam00015 163 QAVARMDQVT 172
Tar_Tsr_sensor cd19407
ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar ...
 45-175 5.09e-27

ligand binding sensor domain of Tar- and Tsr-related chemoreceptors; Escherichia coli Tar (taxis to aspartate and repellents) and Tsr (taxis to serine and repellents) are homologous transmembrane chemoreceptors that have a high specificity for aspartate and serine, respectively. Both are homodimeric receptors and contain an N-terminal periplasmic ligand binding domain, a transmembrane region, a HAMP domain and a C-terminal cytosolic signaling domain. E. coli Tar mediates bacterial chemotaxis toward attractants, including aspartate (Asp) and maltose, and away from repellents such as nickel and cobalt ions. Tsr has many roles, including sensing of external (serine, leucine) and internal (pH) environments. In Salmonella enterica serovar Typhimurium, Tsr, also called methyl-accepting chemotaxis protein (MCP), is involved in sensing host-derived nitrate in murine intestinal epithelium, thus contributing to invasion of Peyer's patches. This model represents the ligand binding domain of Tar and Tsr.


Pssm-ID: 438625 [Multi-domain]  Cd Length: 131  Bit Score: 105.87  E-value: 5.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  45 VLNAQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPASlAAINKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAALTDE 124
Cdd:cd19407    2 QLRQQQSALNDSWVALLQARNTLNRAAIRYLLDANNGGG-AAVAELLDQAKKSLAQAEKHFAQFKALPKLPGQDEALAAE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 647321352 125 MQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENN 175
Cdd:cd19407   81 LEQSYQAYHDALAELIQFLEAGNIDAFLDQPTQGYQDAFEKAYNAYLAQNN 131
TarH pfam02203
Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a ...
 26-181 1.15e-26

Tar ligand binding domain homolog; This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate and also recognizes proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426656 [Multi-domain]  Cd Length: 152  Bit Score: 105.46  E-value: 1.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352   26 GGLFYSAVSNDRHNFQNSGVLN-AQQESLSDSVNTLVKTRVTVTRVAIRYLKNQRDPAslaaiNKLLGTAGDSLAKAEAY 104
Cdd:pfam02203   1 GGLGLSGLSRSNDALREVYTNRlQQQAALADAWLLLLQARLTLNRAGIAALLPDAPDA-----AELLARARESLAQSDAA 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 647321352  105 NKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLKAA 181
Cdd:pfam02203  76 WKAYLALPRTPDEEEALAAELKAKYDALQDGLAPLIAALRAGDLDAFFDQPTQKIQPLFEALYNAYLALRKFQNDAA 152
TarH smart00319
Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the ...
 46-182 1.64e-19

Homologues of the ligand binding domain of Tar; Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.


Pssm-ID: 128614 [Multi-domain]  Cd Length: 135  Bit Score: 84.82  E-value: 1.64e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352    46 LNAQQESLSDSVNTLVKTRVTVTRVAIRYlkNQRDPASLAaiNKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAALTDEM 125
Cdd:smart00319   3 SSYQQAALSLSRVLLLQARNNLNRAGIRM--MQNNIGSKA--KKLMTAASESLKQAEKNYKSYENMTALPRADRALDAEL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 647321352   126 QKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLKAAA 182
Cdd:smart00319  79 KEKFQQYITALQELIQILGNGNLGAFFDQPTQGMQDGFDPAYRDWLQQAVALKGQAV 135
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
216-268 1.32e-09

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 53.79  E-value: 1.32e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 647321352   216 HLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEMQQSLVTTVS 268
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
216-265 3.61e-09

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 52.63  E-value: 3.61e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 647321352  216 HLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEMQQSLVT 265
Cdd:pfam00672   4 RRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLRE 53
HAMP cd06225
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ...
 219-263 1.62e-08

Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.


Pssm-ID: 381743 [Multi-domain]  Cd Length: 45  Bit Score: 50.52  E-value: 1.62e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 647321352 219 LKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEMQQSL 263
Cdd:cd06225    1 TRPLRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 195-263 6.42e-08

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 54.97  E-value: 6.42e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 647321352 195 TLAAILLAVIAVLVVIWQGLQ--HLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEMQQSL 263
Cdd:COG5000    8 LLLLLLIALLLLLLALWLALLlaRRLTRPLRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQL 78
antiphage_ZorA_1 NF033914
anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel ...
 248-514 1.02e-06

anti-phage ZorAB system protein ZorA; Proteins of this subfamily are putative H+ channel proteins, but it has been reported that they are also involved in anti-phage defense.


Pssm-ID: 411475 [Multi-domain]  Cd Length: 619  Bit Score: 51.53  E-value: 1.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 248 EMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTeqqAASLEETA----ASMEELTATVKQNSD-- 321
Cdd:NF033914 291 ELRELAETLKQMQGSLVEMQGGLRGSGEDFARRMSEAAENLNRLVSDA---GSSLGDSAeqsrDALAEVVAALRQTFEka 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 322 NARQATLLAKNASETAAR----GGHVVDNVVRTMTEIADSSQqiahitgvidsiAFQTNilaLNAAVEAARAGEQgrgfA 397
Cdd:NF033914 368 NAEVDEALGAAAGGASGKleeaMGRVLEKLEAQIGGLGEGLG------------AFQGT---LAEQLDETREQIA----A 428

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 398 VVAGEVRTLASRSAQAAKEIKGLIENSVSRVNtgsEQVSEAGSTMKEIVAAVTRVTDIMGEISSasdeQSRgieQVSLAV 477
Cdd:NF033914 429 AQQSAAAAVASASAEAAEALRDGLADALATIR---AEIDRFEAAMRASEGALASQANAIGDATS----QTR---KVADAF 498

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 647321352 478 SQM-DSVTQQNAALVQQSATAAAALEDQSEQLRQAVAA 514
Cdd:NF033914 499 SKTaQDVRAAAAPLAQSGERIAGATESMAESVGRTVEA 536
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
198-304 6.22e-06

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 48.90  E-value: 6.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 198 AILLAVIAVLVVIWqgLQHLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEMQQslvttvsavrgstdsi 277
Cdd:PRK10600 131 AVFMALLLVFTIIW--LRRRLLQPWRQLLSMANAVSHRDFTQRANISGRDEMAMLGTALNNMSA---------------- 192

                         90       100
                 ....*....|....*....|....*..
gi 647321352 278 ytgagEIAAGSNDLSARTEQQAASLEE 304
Cdd:PRK10600 193 -----ELAESYAVLEQRVQEKTAGLEQ 214
HAMP COG2770
HAMP domain [Signal transduction mechanisms];
140-514 1.45e-04

HAMP domain [Signal transduction mechanisms];


Pssm-ID: 442051 [Multi-domain]  Cd Length: 631  Bit Score: 44.72  E-value: 1.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 140 IEYLRADNYQAYGDLDAQQAQDDMEAVYNRWRAENNTLLKAAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLL 219
Cdd:COG2770  158 LALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRIT 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 220 KPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQA 299
Cdd:COG2770  238 RPLRRLAEAARRIAAGDLDVRIPVSRKDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLL 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 300 ASLEETAASMEELTATVKQNSDNARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILA 379
Cdd:COG2770  318 LALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAA 397

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 380 LNAAVEAARAGEQGRGFAVVAGEVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEI 459
Cdd:COG2770  398 LAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAAAAEAEGGLAELEAEELVAAAEALLLLAA 477

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 647321352 460 SSASDEQSRGIEQVSLAVSQMDSVTQQNAALVQQSATAAAALEDQSEQLRQAVAA 514
Cdd:COG2770  478 LLLLAALGALELLLLEEEEEAGAAAEELAEELLLLEGLLLLLLLEAEALEVAEEL 532
NarQ COG3850
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ...
 82-515 4.26e-04

Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];


Pssm-ID: 443059 [Multi-domain]  Cd Length: 448  Bit Score: 42.95  E-value: 4.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352  82 ASLAAINKLLGTAGDSLAKAEAYNKAWQKLPQVNGQNAALTDEMQKSWNQMHEVMRLSIEYLRADNYQAYGDLDAQQAQD 161
Cdd:COG3850    6 LLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLLLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 162 DMEAVYNRWRAENNTLLKAAAEENQSSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQEI 241
Cdd:COG3850   86 LAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDARV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 242 TLSGRNEMGQLAAGLHEMQQSLVTTVSAVRGSTDSIYTGAGEIAAGSNDLSARTEQQAASLEETAASMEELTATVKQNSD 321
Cdd:COG3850  166 PVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQ 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 322 NARQATLLAKNASETAARGGHVVDNVVRTMTEIADSSQQIAHITGVIDSIAFQTNILALNAAVEAARAGEQGRGFAVVAG 401
Cdd:COG3850  246 DALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIAN 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 402 EVRTLASRSAQAAKEIKGLIENSVSRVNTGSEQVSEAGSTMKEIVAAVTRVTDIMGEISSASDEQSRGIEQVSLAVSQMD 481
Cdd:COG3850  326 ASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLVD 405

                        410       420       430
                 ....*....|....*....|....*....|....
gi 647321352 482 SVTQQNAALVQQSATAAAALEDQSEQLRQAVAAF 515
Cdd:COG3850  406 VEGGVAGEGGLVVLIVSIIAGGEAIARGEALAAR 439
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
188-253 2.51e-03

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 40.39  E-value: 2.51e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 647321352 188 SFTQMQ----WTLAAI--LLAVIAVLVviwqgLQHLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLA 253
Cdd:PRK10549 157 NFDKQQrrtsWLIVALstLLAALATFL-----LARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLA 223
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
187-259 2.57e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 40.39  E-value: 2.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 647321352 187 SSFTQMQWTLAAILLAVIAVLVVIWQGLQHLLLKPLNTIMNHIRAIAGGDLTQeITLSGRNEMGQLAAGLHEM 259
Cdd:COG2972  150 RGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR-LEVSGNDEIGILARSFNEM 221
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 139-257 6.16e-03

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 39.28  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647321352 139 SIEYLRADNYQAygDLDAQQAQDDMEAVYNRWRAENNTLLKAAAEE----NQSSFTQMQ----WTLAAILLAVIAVLVVI 210
Cdd:COG4192  266 GLPSLRRDELAA--QATLEALAEENNSILEQLRTQISGLVGNSREQlvalNQETAQLVQqsgiLLLAIALLSLLLAVLIN 343

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 647321352 211 WQGLQHLLLKPLNTIMNHIRAIAGGDLTQEITLSGRNEMGQLAAGLH 257
Cdd:COG4192  344 YFYVRRRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDEIGRIARLLR 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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