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Conserved domains on  [gi|647614062|ref|WP_025889389|]
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VOC family protein [Shewanella algae]

Protein Classification

VOC family protein( domain architecture ID 10163510)

vicinal oxygen chelate (VOC) family protein uses a metal center to coordinate a substrate, intermediate, or transition state through vicinal oxygen atoms

CATH:  3.10.180.10
PubMed:  21820381

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-115 7.64e-30

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


:

Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 103.11  E-value: 7.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062   7 INYLELPARELEATKAFFQAVFGWGFVDY---GPDYSCFTQAG-IDGGFFRSSLSFDTLNGSPLLVIYSNDLNASLEAVK 82
Cdd:cd07247    1 PVWFELPTTDLERAKAFYGAVFGWTFEDEgdgGGDYALFTAGGgAVGGLMRAPEEVAGAPPGWLIYFAVDDLDAALARVE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 647614062  83 TQGGEICKDIFSFPG-GRRFHFRCPSQNEYAVWS 115
Cdd:cd07247   81 AAGGKVVVPPTDIPGgGRFAVFADPEGNRFGLWS 114
 
Name Accession Description Interval E-value
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-115 7.64e-30

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 103.11  E-value: 7.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062   7 INYLELPARELEATKAFFQAVFGWGFVDY---GPDYSCFTQAG-IDGGFFRSSLSFDTLNGSPLLVIYSNDLNASLEAVK 82
Cdd:cd07247    1 PVWFELPTTDLERAKAFYGAVFGWTFEDEgdgGGDYALFTAGGgAVGGLMRAPEEVAGAPPGWLIYFAVDDLDAALARVE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 647614062  83 TQGGEICKDIFSFPG-GRRFHFRCPSQNEYAVWS 115
Cdd:cd07247   81 AAGGKVVVPPTDIPGgGRFAVFADPEGNRFGLWS 114
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 4-115 5.54e-24

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 88.54  E-value: 5.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062   4 HHRINYLELPARELEATKAFFQAVFGWGFVDY---GPDYSCF-TQAGIDGGFFRSslSFDTLNGSPLLVIYSNDLNASLE 79
Cdd:COG3324    2 PGTIVWVELPVDDLERAKAFYEEVFGWTFEDDagpGGDYAEFdTDGGQVGGLMPG--AEEPGGPGWLLYFAVDDLDAAVA 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 647614062  80 AVKTQGGEICKDIFSFPG-GRRFHFRCPSQNEYAVWS 115
Cdd:COG3324   80 RVEAAGGTVLRPPTDIPPwGRFAVFRDPEGNRFGLWQ 116
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
6-110 9.39e-04

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 36.27  E-value: 9.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062    6 RINYLELPARELEATKAFFQAVFGWGFVD-------YGPDYSCFTQAGIDGGFF-----RSSLSFDTLNGSPLLVIYSND 73
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLVEetdageeGGLRSAFFLAGGRVLELLlnetpPPAAAGFGGHHIAFIAFSVDD 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 647614062   74 LNASLEAVKTQGGEICKDIFSFP-GGRRFHFRCPSQNE 110
Cdd:pfam00903  81 VDAAYDRLKAAGVEIVREPGRHGwGGRYSYFRDPDGNL 118
 
Name Accession Description Interval E-value
SgaA_N_like cd07247
N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth ...
 7-115 7.64e-30

N-terminal domain of Streptomyces griseus SgaA and similar domains; SgaA suppresses the growth disturbances caused by high osmolarity and a high concentration of A-factor, a microbial hormone, during the early growth phase in Streptomyces griseus. A-factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) controls morphological differentiation and secondary metabolism in Streptomyces griseus. It is a chemical signaling molecule that at a very low concentration acts as a switch for yellow pigment production, aerial mycelium formation, streptomycin production, and streptomycin resistance. The structure and amino acid sequence of SgaA are closely related to a group of antibiotics resistance proteins, including bleomycin resistance protein, mitomycin resistance protein, and fosfomycin resistance proteins. SgaA might also function as a streptomycin resistance protein.


Pssm-ID: 319911 [Multi-domain]  Cd Length: 114  Bit Score: 103.11  E-value: 7.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062   7 INYLELPARELEATKAFFQAVFGWGFVDY---GPDYSCFTQAG-IDGGFFRSSLSFDTLNGSPLLVIYSNDLNASLEAVK 82
Cdd:cd07247    1 PVWFELPTTDLERAKAFYGAVFGWTFEDEgdgGGDYALFTAGGgAVGGLMRAPEEVAGAPPGWLIYFAVDDLDAALARVE 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 647614062  83 TQGGEICKDIFSFPG-GRRFHFRCPSQNEYAVWS 115
Cdd:cd07247   81 AAGGKVVVPPTDIPGgGRFAVFADPEGNRFGLWS 114
VOC COG3324
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 4-115 5.54e-24

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442553 [Multi-domain]  Cd Length: 119  Bit Score: 88.54  E-value: 5.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062   4 HHRINYLELPARELEATKAFFQAVFGWGFVDY---GPDYSCF-TQAGIDGGFFRSslSFDTLNGSPLLVIYSNDLNASLE 79
Cdd:COG3324    2 PGTIVWVELPVDDLERAKAFYEEVFGWTFEDDagpGGDYAEFdTDGGQVGGLMPG--AEEPGGPGWLLYFAVDDLDAAVA 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 647614062  80 AVKTQGGEICKDIFSFPG-GRRFHFRCPSQNEYAVWS 115
Cdd:COG3324   80 RVEAAGGTVLRPPTDIPPwGRFAVFRDPEGNRFGLWQ 116
Glyoxalase pfam00903
Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;
6-110 9.39e-04

Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily;


Pssm-ID: 395724 [Multi-domain]  Cd Length: 121  Bit Score: 36.27  E-value: 9.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062    6 RINYLELPARELEATKAFFQAVFGWGFVD-------YGPDYSCFTQAGIDGGFF-----RSSLSFDTLNGSPLLVIYSND 73
Cdd:pfam00903   1 RIDHVALRVGDLEKSLDFYTDVLGFKLVEetdageeGGLRSAFFLAGGRVLELLlnetpPPAAAGFGGHHIAFIAFSVDD 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 647614062   74 LNASLEAVKTQGGEICKDIFSFP-GGRRFHFRCPSQNE 110
Cdd:pfam00903  81 VDAAYDRLKAAGVEIVREPGRHGwGGRYSYFRDPDGNL 118
COG3607 COG3607
Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function ...
 5-106 9.33e-03

Lactoylglutathione lyase-related enzyme, vicinal oxygen chelate (VOC) family [General function prediction only];


Pssm-ID: 442825  Cd Length: 126  Bit Score: 33.65  E-value: 9.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 647614062   5 HRINYLELPARELEATKAFFQAvFGWGFVDY--GPDYSCFTqagIDGGFF-----RSSLS-------FDTLNGSPLLVIY 70
Cdd:COG3607    2 PRIIFVNLPVADLERSRAFYEA-LGFTFNPQfsDEGAACFV---LGEGIVlmllpREKFAtftgkpiADATGFTEVLLAL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 647614062  71 S----NDLNASLEAVKTQGGEICKDIFSFPGGRRFHFRCP 106
Cdd:COG3607   78 NvesrEEVDALVAKALAAGGTVLKPPQDVGGMYSGYFADP 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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