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Conserved domains on  [gi|648228523|ref|WP_026009672|]
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GntR family transcriptional regulator [Priestia filamentosa]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
13-239 1.24e-54

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 175.44  E-value: 1.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:COG2188    5 PLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  93 TEVLVEEGHKIQRQLLQAEVV-CNEE-----GTEPyrlfGEHCLRVERLYHLDDVPYIHYTHYVTTQI-EGTERSDLNTQ 165
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVpADEEvaealGLPP----GAPVLRIERLRLADGEPVALETSYLPAALfPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523 166 SLYEVIEEQ-DISLEKFRDQFAVAIAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTEMQHYVVNY 239
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
13-239 1.24e-54

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 175.44  E-value: 1.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:COG2188    5 PLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  93 TEVLVEEGHKIQRQLLQAEVV-CNEE-----GTEPyrlfGEHCLRVERLYHLDDVPYIHYTHYVTTQI-EGTERSDLNTQ 165
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVpADEEvaealGLPP----GAPVLRIERLRLADGEPVALETSYLPAALfPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523 166 SLYEVIEEQ-DISLEKFRDQFAVAIAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTEMQHYVVNY 239
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
PRK11402 PRK11402
transcriptional regulator PhoB;
13-174 4.02e-22

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 91.05  E-value: 4.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  93 TEVLVEEGHKIQRQLLQAEVVCNEEGTEPYRLFGE-HCLRVERLYHLDDVP-YIHYTHYVTTQIEGTERSDLNTQSLYEV 170
Cdd:PRK11402  89 TDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGNsEVFHLCRVMYLDKEPlFIDSSWIPLSRYPDFDEIYVEGSSTYQL 168


                 ....
gi 648228523 171 IEEQ 174
Cdd:PRK11402 169 FQER 172
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-77 1.33e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 82.11  E-value: 1.33e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKV 77
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 98-231 2.35e-17

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 75.71  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523   98 EEGHKIQRQLLQAEVV-CNEEGTEPYRL-FGEHCLRVERLYHLDDVPYIHYTHYVTTQI-EGTERSDLNTQSLYEVIEEQ 174
Cdd:pfam07702   1 AQGREPKTEVLSLEEVpASAEIAEALGLpPGEPVYRIERLRYADGEPVALEEDYLPAELvPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 648228523  175 -DISLEKFRDQFAVAIAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTE 231
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGD 138
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 98-231 3.86e-14

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 67.32  E-value: 3.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523    98 EEGHKIQRQLLQAEVV-CNEEgtEPYRLF---GEHCLRVERLYHLDDVPYIHYTHYVTTQI-EGTERSDLnTQSLYEVIE 172
Cdd:smart00866   1 AQGRKPTTKVLSFERVpADEE--LAEALGlppGDPVYRIERLRLADGEPVALETTYLPAALfPGLLEEDL-SGSLYEYLE 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648228523   173 EQ----DISLEKFRDQFAVAIAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTE 231
Cdd:smart00866  78 ERlglkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 9-237 1.09e-13

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 68.27  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523    9 RKKGP-LYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLS 87
Cdd:TIGR02325   3 RTSGVaLWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523   88 KGKRFTEVLVEEGHKIQRQLLQA--EVVCNEEGTEPYRLFGEHCLRVERLYHLDDVPYIHYTHYVTT-QIEGTERSDLNT 164
Cdd:TIGR02325  83 ARTRFSQNLADQGREPTGELLLSdlEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAaRFPGIGQAYAAS 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523  165 QSLYEVIEEQDISlEKFRDQFAVA--IAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTEMQHYVV 237
Cdd:TIGR02325 163 GSITDALREQGVA-DYRRSSTRISarHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTM 236
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
13-239 1.24e-54

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 175.44  E-value: 1.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:COG2188    5 PLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  93 TEVLVEEGHKIQRQLLQAEVV-CNEE-----GTEPyrlfGEHCLRVERLYHLDDVPYIHYTHYVTTQI-EGTERSDLNTQ 165
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVpADEEvaealGLPP----GAPVLRIERLRLADGEPVALETSYLPAALfPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523 166 SLYEVIEEQ-DISLEKFRDQFAVAIAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTEMQHYVVNY 239
Cdd:COG2188  161 SLYELLEERyGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVEL 235
PRK11402 PRK11402
transcriptional regulator PhoB;
13-174 4.02e-22

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 91.05  E-value: 4.02e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  93 TEVLVEEGHKIQRQLLQAEVVCNEEGTEPYRLFGE-HCLRVERLYHLDDVP-YIHYTHYVTTQIEGTERSDLNTQSLYEV 170
Cdd:PRK11402  89 TDFGVSQGKATKEKVIEQERVSAAPFCEKLNIPGNsEVFHLCRVMYLDKEPlFIDSSWIPLSRYPDFDEIYVEGSSTYQL 168


                 ....
gi 648228523 171 IEEQ 174
Cdd:PRK11402 169 FQER 172
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 13-77 1.33e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 82.11  E-value: 1.33e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKV 77
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 98-231 2.35e-17

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 75.71  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523   98 EEGHKIQRQLLQAEVV-CNEEGTEPYRL-FGEHCLRVERLYHLDDVPYIHYTHYVTTQI-EGTERSDLNTQSLYEVIEEQ 174
Cdd:pfam07702   1 AQGREPKTEVLSLEEVpASAEIAEALGLpPGEPVYRIERLRYADGEPVALEEDYLPAELvPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 648228523  175 -DISLEKFRDQFAVAIAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTE 231
Cdd:pfam07702  81 yGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGD 138
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
13-99 2.67e-14

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 66.74  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:COG1725   10 PIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEERREEF 89


                 ....*..
gi 648228523  93 TEVLVEE 99
Cdd:COG1725   90 LEEALRE 96
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 98-231 3.86e-14

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 67.32  E-value: 3.86e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523    98 EEGHKIQRQLLQAEVV-CNEEgtEPYRLF---GEHCLRVERLYHLDDVPYIHYTHYVTTQI-EGTERSDLnTQSLYEVIE 172
Cdd:smart00866   1 AQGRKPTTKVLSFERVpADEE--LAEALGlppGDPVYRIERLRLADGEPVALETTYLPAALfPGLLEEDL-SGSLYEYLE 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648228523   173 EQ----DISLEKFRDQFAVAIAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTE 231
Cdd:smart00866  78 ERlglkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 9-237 1.09e-13

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 68.27  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523    9 RKKGP-LYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLS 87
Cdd:TIGR02325   3 RTSGVaLWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523   88 KGKRFTEVLVEEGHKIQRQLLQA--EVVCNEEGTEPYRLFGEHCLRVERLYHLDDVPYIHYTHYVTT-QIEGTERSDLNT 164
Cdd:TIGR02325  83 ARTRFSQNLADQGREPTGELLLSdlEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAaRFPGIGQAYAAS 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523  165 QSLYEVIEEQDISlEKFRDQFAVA--IAPSYVEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTEMQHYVV 237
Cdd:TIGR02325 163 GSITDALREQGVA-DYRRSSTRISarHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTM 236
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 14-77 4.33e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 62.25  E-value: 4.33e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 648228523   14 LYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKV 77
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
10-84 1.88e-12

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 64.57  E-value: 1.88e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648228523  10 KKGPLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSAS 84
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWA 78
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
18-77 1.49e-11

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 57.97  E-value: 1.49e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523    18 IKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKV 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK09764 PRK09764
GntR family transcriptional regulator;
13-231 4.99e-11

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 60.61  E-value: 4.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  93 TEVLVEEGHKIQRQLLQAEVV-CNEEGTEPYRLF-GEHCLRVERLYHLDDVPYIHYTHYVTTQIEGTERSDLNTQSLYEV 170
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIpADDFLQQQLQITaQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHF 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648228523 171 IEEQDISLEKFRDQFAVAIAPSY-VEDRLHVKRKTPLLKRLRYSYDEMGNLIEYSEGYYNTE 231
Cdd:PRK09764 165 IEEVKKMVIDRSEQEIIPLMPTEeMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTD 226
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 11-87 1.01e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 61.00  E-value: 1.01e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 648228523  11 KGPLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLS 87
Cdd:COG1167   10 SGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAPA 86
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 15-199 4.64e-10

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 57.76  E-value: 4.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523   15 YLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVI-RNTSASKLSKGKRFT 93
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLnRKQIEFPISGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523   94 EVLVEEGHKIqrqllQAEVVCNE-EGTEPYRL-------FGEHCLRVERLYHLDDVPYIHYTHYVTTQIEGTERSDLNTQ 165
Cdd:TIGR02404  82 ELNETLGLDS-----KTEVVELDkEDPLPETLaqltgleEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAED 156

                         170       180       190
                  ....*....|....*....|....*....|....
gi 648228523  166 SLYEVIeEQDISLEKFRDQFAVAIAPSYVEDRLH 199
Cdd:TIGR02404 157 SIYQYL-ENELGLAISYAQKEITVEPCTDEDKKL 189
PRK14999 PRK14999
histidine utilization repressor; Provisional
 13-155 5.44e-10

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 57.64  E-value: 5.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  13 PLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRF 92
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSI 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 648228523  93 TEVLVEEGH----------KIQRQLLQAEVVCNEEGTepyRLFgeHCLRVerlyhlddvpyiHYTHYVTTQIE 155
Cdd:PRK14999  92 AEEIAARRHqhrcevltleRVRANAIQASALNVNESD---VIF--HSIMV------------HYENDLPVQIE 147
PRK11523 PRK11523
transcriptional regulator ExuR;
14-80 1.01e-09

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 57.16  E-value: 1.01e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 648228523  14 LYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRN 80
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVVSN 75
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 27-224 1.15e-07

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 50.93  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523  27 LHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKLSKGKRFTEVLVEEG-HKIQR 105
Cdd:PRK10079  25 LRQHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFSQNLLDQGsHPTSE 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523 106 QLLQAEVVCNEEGTEPYRLF-GEHCLRVERLYHLDDVPYIHYTHYVTTQIEGTERSDLNTQSLYEVIEEQ-DISLEKFRD 183
Cdd:PRK10079 105 KLLSVLRPASGHVADALGITeGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTLQRFDSGSLHDFLREQlGIALRRSQT 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 648228523 184 QFAVAIAPSYVEDRLHVKRKTPLL-KRLRYSYDEMGNLIEYS 224
Cdd:PRK10079 185 RISARRAQAKESQLLEIPNMSPLLcVRTLNHRDGESSPAEYS 226
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
4-77 5.83e-07

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 48.77  E-value: 5.83e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648228523   4 TVNVSRKKGPLYLQIKNILKDRILHGVYPiktniP----SEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKV 77
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELP-----PgerlSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV 74
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 37-77 4.51e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 40.52  E-value: 4.51e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 648228523  37 IPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKV 77
Cdd:PRK10421  26 LPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
Tox-ART-HYE1 pfam15634
HYE1 signature containing ADP-ribosyltransferase; A predicted toxin of the ...
 4-128 6.54e-04

HYE1 signature containing ADP-ribosyltransferase; A predicted toxin of the ADP-ribosyltransferase superfamily present in bacterial polymorphic toxin systems. The domain has characteriztic histidine, tyrosine and glutamate residues that comprise the active site.


Pssm-ID: 292267  Cd Length: 282  Bit Score: 40.11  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523    4 TVNVSRKKgplylqiKNILKDRIL------HGVYPIKTNIPSEPQLENEfnVSKITIRNAIKELVQEGYLEKKSGKGTKV 77
Cdd:pfam15634  77 TINKNRKA-------KKISKDNFLmpqefwHEFKNFYQNIPTQTNIDDQ--LLKKSITESIDKLDQNKFMEKHSDRKQTI 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 648228523   78 IRNTSASKLSKGKRFTEVLVEEGHKIQRQllqaevvcNEEGTEPYRLFGEH 128
Cdd:pfam15634 148 INNEREAILQQDERINEIISSRAKMIQQR--------EAENTEGYIYLAPH 190
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 7-87 3.19e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 37.69  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648228523   7 VSRKKgpLYLQIKNILKDRILHGVYPIKTNIPSEPQLENEFNVSKITIRNAIKELVQEGYLEKKSGKGTKVIRNTSASKL 86
Cdd:PRK03837   9 IARKK--LSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRPSADTII 86


                 .
gi 648228523  87 S 87
Cdd:PRK03837  87 G 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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