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Conserved domains on  [gi|648556643|ref|WP_026248394|]
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flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [Streptomyces sp. LaPpAH-108]

Protein Classification

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase( domain architecture ID 10011395)

flavodoxin/ferredoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate, part of an alternative non-mevalonate pathway for isoprenoid biosynthesis

CATH:  3.30.413.10|3.20.20.20
EC:  1.17.7.-
Gene Ontology:  GO:0016114|GO:0046429|GO:0005506|GO:0051539|GO:0019288
SCOP:  4001495|4003972|4004884

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
10-372 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


:

Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 657.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  10 SIPTKIAERRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARKSQ 89
Cdd:PRK00366   1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  90 IPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEALVE 169
Cdd:PRK00366  81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 170 SALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVS 249
Cdd:PRK00366 161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 250 LSAPPAEEVKVGLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAREA 329
Cdd:PRK00366 241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGP---GEAKEA 317

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 648556643 330 DLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKLAEQM 372
Cdd:PRK00366 318 DIGIAGGNPKGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
10-372 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 657.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  10 SIPTKIAERRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARKSQ 89
Cdd:PRK00366   1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  90 IPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEALVE 169
Cdd:PRK00366  81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 170 SALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVS 249
Cdd:PRK00366 161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 250 LSAPPAEEVKVGLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAREA 329
Cdd:PRK00366 241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGP---GEAKEA 317

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 648556643 330 DLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKLAEQM 372
Cdd:PRK00366 318 DIGIAGGNPKGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
 8-376 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 617.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   8 MPSIPTKiaeRRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARK 87
Cdd:COG0821    1 MPSSPIP---RRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  88 SQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKqFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEAL 167
Cdd:COG0821   78 LPVPLVADIHFDYRLALEAAEAGVDKLRINPGNIG-SDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEAL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 168 VESALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIR 247
Cdd:COG0821  157 VESALEHARILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIR 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 248 VSLSAPPAEEVKVGLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAR 327
Cdd:COG0821  237 VSLTADPVEEVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRDIKEPLKVAVMGCVVNGP---GEAK 313

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 648556643 328 EADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKLAEQMQDEG 376
Cdd:COG0821  314 EADIGIAGGGGEGLLFKKGEIIRKVPEDEIVEELLEEIEKYVAERYGEG 362
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
 21-364 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 583.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   21 SRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQP 100
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  101 KYVFAAIEAGCAAVRVNPGNIKqFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEALVESALWEASLFEE 180
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNIG-SEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  181 HDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEVKV 260
Cdd:pfam04551 160 LGFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  261 GLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAREADLGVASGNGKG 340
Cdd:pfam04551 240 AKEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEHLKKPLKVAVMGCVVNGP---GEAKEADIGIAGGKGEG 316

                         330       340
                  ....*....|....*....|....
gi 648556643  341 QIFVKGEVIKTVPESKIVETLIEE 364
Cdd:pfam04551 317 LLFKKGEIVRKVPEEELVEELLEE 340
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
 18-364 1.09e-151

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 431.85  E-value: 1.09e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   18 RRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIH 97
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   98 FQPKYVFAAIEAGCAAVRVNPGNIKqFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEALVESALWEASL 177
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNIG-FEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  178 FEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEE 257
Cdd:TIGR00612 160 LEKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  258 VKVGLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAREADLG-VASG 336
Cdd:TIGR00612 240 VPVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALSHLKTPLKVAVMGCVVNGP---GEAKHADIGiSGPG 316

                         330       340
                  ....*....|....*....|....*...
gi 648556643  337 NGKGQIFVKGEVIKTVPESKIVETLIEE 364
Cdd:TIGR00612 317 TGFAWLFKHGKPKAKVPETDMVDELIKL 344
 
Name Accession Description Interval E-value
ispG PRK00366
flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;
10-372 0e+00

flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase;


Pssm-ID: 234737 [Multi-domain]  Cd Length: 360  Bit Score: 657.92  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  10 SIPTKIAERRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARKSQ 89
Cdd:PRK00366   1 MRPSTPIPRRKTRQVKVGNVPIGGDAPIVVQSMTNTDTADVEATVAQIKRLARAGCEIVRVAVPDMEAAAALPEIKKQLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  90 IPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKQFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEALVE 169
Cdd:PRK00366  81 VPLVADIHFDYRLALAAAEAGADALRINPGNIGKRDERVREVVEAAKDYGIPIRIGVNAGSLEKDLLEKYGEPTPEALVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 170 SALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVS 249
Cdd:PRK00366 161 SALRHAKILEELGFDDIKISVKASDVQDLIAAYRLLAKRCDYPLHLGVTEAGMGFKGTVKSAAGLGALLQEGIGDTIRVS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 250 LSAPPAEEVKVGLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAREA 329
Cdd:PRK00366 241 LTADPVEEVKVGQEILQSLGLRSRGPEVISCPTCGRTEFDVIQELAEVEQRLEHIKMPLKVAVMGCVVNGP---GEAKEA 317

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 648556643 330 DLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKLAEQM 372
Cdd:PRK00366 318 DIGIAGGNPKGPVFVDGEKIKTLPEENIVEELEAEIEAYAEER 360
IspG COG0821
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism] ...
 8-376 0e+00

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE [Lipid transport and metabolism]; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG/GcpE is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440583 [Multi-domain]  Cd Length: 363  Bit Score: 617.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   8 MPSIPTKiaeRRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARK 87
Cdd:COG0821    1 MPSSPIP---RRKTRQVRVGNVAIGGGAPISVQSMTNTDTADVEATVAQIKALAEAGCEIVRVAVPDEEAAAALPEIKKQ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  88 SQIPVIADIHFQPKYVFAAIEAGCAAVRVNPGNIKqFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEAL 167
Cdd:COG0821   78 LPVPLVADIHFDYRLALEAAEAGVDKLRINPGNIG-SDEKVREVVEAAKERGIPIRIGVNAGSLEKDLLEKYGDPTPEAL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 168 VESALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIR 247
Cdd:COG0821  157 VESALEHARILEELGFDDIKISLKASDVQDTIAAYRLLAERCDYPLHLGVTEAGTGRKGTVKSAAGLGILLAEGIGDTIR 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 248 VSLSAPPAEEVKVGLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAR 327
Cdd:COG0821  237 VSLTADPVEEVKVAQEILKSLGLRSRGPEVISCPTCGRTEIDLIQLAEEVEERLRDIKEPLKVAVMGCVVNGP---GEAK 313

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 648556643 328 EADLGVASGNGKGQIFVKGEVIKTVPESKIVETLIEEAMKLAEQMQDEG 376
Cdd:COG0821  314 EADIGIAGGGGEGLLFKKGEIIRKVPEDEIVEELLEEIEKYVAERYGEG 362
GcpE pfam04551
GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids ...
 21-364 0e+00

GcpE protein; In a variety of organizms, including plants and several eubacteria, isoprenoids are synthesized by the mevalonate-independent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Although different enzymes of this pathway have been described, the terminal biosynthetic steps of the MEP pathway have not been fully elucidated. GcpE gene of Escherichia coli is involved in this pathway.


Pssm-ID: 428003 [Multi-domain]  Cd Length: 343  Bit Score: 583.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   21 SRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQP 100
Cdd:pfam04551   1 TRQVRVGNVPIGGGAPIVVQSMTNTDTRDVEATVAQIRRLAEAGCEIVRVAVPDMEAAEALKEIKKRLPIPLVADIHFDY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  101 KYVFAAIEAGCAAVRVNPGNIKqFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEALVESALWEASLFEE 180
Cdd:pfam04551  81 RLALEAAEAGVDKIRINPGNIG-SEEKVREVVEAAKERGIPIRIGVNSGSLEKDLLEKYGGPTPEALVESALEHVRILEE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  181 HDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEVKV 260
Cdd:pfam04551 160 LGFDDIVISLKASDVPLTVEAYRLLAERCDYPLHLGVTEAGTGESGTIKSAVGIGALLAEGIGDTIRVSLTGDPVEEVKV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  261 GLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAREADLGVASGNGKG 340
Cdd:pfam04551 240 AKEILQSLGLRKRGVEIISCPTCGRTEIDLIELAEEVEERLEHLKKPLKVAVMGCVVNGP---GEAKEADIGIAGGKGEG 316

                         330       340
                  ....*....|....*....|....
gi 648556643  341 QIFVKGEVIKTVPESKIVETLIEE 364
Cdd:pfam04551 317 LLFKKGEIVRKVPEEELVEELLEE 340
ispG_gcpE TIGR00612
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown ...
 18-364 1.09e-151

1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; This protein of previously unknown biochemical function has now been identified as an enzyme of the non-mevalonate pathway of IPP biosynthesis. Chlamydial members of the family have a long insert. The family is largely restricted to Bacteria, where it is widely but not universally distributed. No homology can be detected between the GcpE family and other proteins. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 273174 [Multi-domain]  Cd Length: 346  Bit Score: 431.85  E-value: 1.09e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   18 RRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIH 97
Cdd:TIGR00612   1 RRKTRQVRVGNVKVGGDAPIVVQSMTNTDTHDVDATVAQIRRLEEAGCEIVRVTVPDKESAEALEEIKEGSNVPLVADIH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   98 FQPKYVFAAIEAGCAAVRVNPGNIKqFDDKVKEIARAAKDHGTPIRIGVNAGSLDRRLLQKYGKATPEALVESALWEASL 177
Cdd:TIGR00612  81 FAYSYAALAMAKGVAKVRINPGNIG-FEERVRDIVEKARRHGKAMRIGVNHGSLERRLLEKYGDPTAEAMVQSALEWAEI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  178 FEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEE 257
Cdd:TIGR00612 160 LEKLGFRNVVVSMKASDVLQTVAAYRLLAERSDYPLHLGVTEAGMGVKGIIKSSVGIGILLAMGIGDTIRVSLTDDPVVE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  258 VKVGLQILESLNLKQRGLEIVSCPSCGRAQVDVYKLAEEVTAGLTGMEVPLRVAVMGCVVNGPgqgGEAREADLG-VASG 336
Cdd:TIGR00612 240 VPVAYEILQSLGLRRRGVEIVACPSCGRTGFDLEKVVKEVQEALSHLKTPLKVAVMGCVVNGP---GEAKHADIGiSGPG 316

                         330       340
                  ....*....|....*....|....*...
gi 648556643  337 NGKGQIFVKGEVIKTVPESKIVETLIEE 364
Cdd:TIGR00612 317 TGFAWLFKHGKPKAKVPETDMVDELIKL 344
PRK00694 PRK00694
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated
 8-266 1.46e-63

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated


Pssm-ID: 234812  Cd Length: 606  Bit Score: 213.93  E-value: 1.46e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643   8 MPSIPTKIAERRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATI--- 84
Cdd:PRK00694   2 MATPCIQNAFRRKTHPVRIGNLFVGSEHSIKIQSMTTTATTDVDGTVRQICALQEWGCDIVRVTVQGLKEAQACEHIker 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  85 --ARKSQIPVIADIHFQPKyvfAAIE-AGCA-AVRVNPGN---------------------IKQFDDKVKEIARAAKDHG 139
Cdd:PRK00694  82 liQQGISIPLVADIHFFPQ---AAMHvADFVdKVRINPGNyvdkrnmftgkiytdeqyahsLLRLEEKFSPLVEKCKRLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 140 TPIRIGVNAGSLDRRLLQKYGKaTPEALVESALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCD-----YPLH 214
Cdd:PRK00694 159 KAMRIGVNHGSLSERVMQRYGD-TIEGMVYSALEYIEVCEKLDYRDVVFSMKSSNPKVMVAAYRQLAKDLDargwlYPLH 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 648556643 215 LGVTEAGPAFQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEVKVGLQILE 266
Cdd:PRK00694 238 LGVTEAGSGTDGIIKSAVGIGTLLSEGLGDTIRCSLTGCPTNEIPVCISLLK 289
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
 18-258 1.49e-62

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 213.47  E-value: 1.49e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  18 RRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATI-----ARKSQIPV 92
Cdd:PLN02925  77 RRKTRTVMVGNVALGSEHPIRIQTMTTTDTKDVEATVDQVMRIADKGADIVRITVQGKKEADACFEIkntlvQKGYNIPL 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  93 IADIHFQPKyvFAAIEAGC-AAVRVNPGNI----KQFDDKV-------KEIAR----------AAKDHGTPIRIGVNAGS 150
Cdd:PLN02925 157 VADIHFAPS--VALRVAECfDKIRVNPGNFadrrAQFEKLEyteddyqKELEHieevftplveKCKKYGRAMRIGTNHGS 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 151 LDRRLLQKYGKaTPEALVESALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQC-----DYPLHLGVTEAGPAFQ 225
Cdd:PLN02925 235 LSDRIMSYYGD-SPRGMVESAFEFARICRKLDYHNFVFSMKASNPVVMVQAYRLLVAEMyvlgwDYPLHLGVTEAGEGED 313

                        250       260       270
                 ....*....|....*....|....*....|...
gi 648556643 226 GTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEV 258
Cdd:PLN02925 314 GRMKSAIGIGTLLQDGLGDTIRVSLTEPPEEEI 346
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
 17-272 4.41e-61

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 207.38  E-value: 4.41e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  17 ERRKSRQIQVGTVAVGGDAPVSVQSMTTTRTSDIGSTLQQIAELTASGCQIVRVACPTQDDADALATI-----ARKSQIP 91
Cdd:PRK02048   7 SRRKTSVVNIGATPLGGPNPIRIQSMTNTSTMDTEACVAQAKRIIDAGGEYVRLTTQGVREAENLMNIniglrSQGYMVP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  92 VIADIHFQPKYV-FAAIEAgcAAVRVNPGN---------------------IKQFDDKVKEIARAAKDHGTPIRIGVNAG 149
Cdd:PRK02048  87 LVADVHFNPKVAdVAAQYA--EKVRINPGNyvdpgrtfkkleytdeeyaqeIQKIRDRFVPFLNICKENHTAIRIGVNHG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 150 SLDRRLLQKYGKaTPEALVESALWEASLFEEHDFRDIKISVKHNDPVVMIEAYRQLAAQCD-----YPLHLGVTEAGPAF 224
Cdd:PRK02048 165 SLSDRIMSRYGD-TPEGMVESCMEFLRICVEEHFTDVVISIKASNTVVMVRTVRLLVAVMEaegmhYPLHLGVTEAGDGE 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 648556643 225 QGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEVKVGLQILESLNLKQ 272
Cdd:PRK02048 244 DGRIKSAVGIGALLADGIGDTIRVSLSEEPEAEIPVARKLVDYIRSRE 291
PRK02048 PRK02048
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional
 228-363 5.15e-18

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional


Pssm-ID: 179361  Cd Length: 611  Bit Score: 85.65  E-value: 5.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 228 IKSAVAFGALLSQGIGDTIRV----SLSAPPAEEVKVGlqILESLNLKQRGLEIVSCPSCGRAQVDVYKLA---EEVTAG 300
Cdd:PRK02048 467 LKAAADMGALIFDGLCDGIFLfnqgKLSHVVVDATAFG--ILQAGRLRTSKTEYISCPGCGRTLYDLQSTIariKEATSH 544

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 648556643 301 LTGmevpLRVAVMGCVVNGPgqgGEAREADLG-VASGNGKGQIFVKGE-VIKTVPESKIVETLIE 363
Cdd:PRK02048 545 LKG----LKIGIMGCIVNGP---GEMADADYGyVGAGRGKISLYKQKEcVEKNIPEEEAVERLIE 602
PRK00694 PRK00694
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated
 224-377 3.03e-17

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated


Pssm-ID: 234812  Cd Length: 606  Bit Score: 83.35  E-value: 3.03e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 224 FQGTIKSAVAFGALLSQGIGDTIRVSLSAPPAEEV-KVGLQILESLNLKQRGLEIVSCPSCGRAQVD---VYKLAEEVTA 299
Cdd:PRK00694 456 NEAAIDIATEFGALLLDGLGECVLLDLPNIKLSDVrTIAFGTLQSAGVRLVKTEYISCPGCGRTLFDlleVTQRIRERTQ 535

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 300 GLTGmevpLRVAVMGCVVNGPgqgGEAREADLG-VASGNGKGQIFVKGEVIKT-VPeskiVETLIEEAMKLaeqMQDEGV 377
Cdd:PRK00694 536 HLPG----LKIAVMGCIVNGP---GEMADADFGfVGSKTGMIDLYVKHTCVKAhIP----MENAEEELVQL---LKEHGV 601
PLN02925 PLN02925
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
 228-363 6.53e-12

4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase


Pssm-ID: 178513  Cd Length: 733  Bit Score: 67.09  E-value: 6.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 228 IKSAVAFGALLSQGIGDTIRVSLSAPPAEEVK-VGLQILESLNLKQRGLEIVSCPSCGRAQVDVyklaEEVTAGL---TG 303
Cdd:PLN02925 584 IQAGSQAGALLVDGLGDGVLLEAPDQDFDFLRnTSFGLLQGCRMRNTKTEYVSCPSCGRTLFDL----QEVSAEIrekTS 659

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648556643 304 MEVPLRVAVMGCVVNGPgqgGEAREADLG-VASGNGKGQIFVKGEVIK-TVPESKIVETLIE 363
Cdd:PLN02925 660 HLPGVSIAIMGCIVNGP---GEMADADFGyVGGAPGKIDLYVGKEVVKrGIAMEEATDALIQ 718
YcjR COG1082
Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];
36-268 1.19e-03

Sugar phosphate isomerase/epimerase [Carbohydrate transport and metabolism];


Pssm-ID: 440699 [Multi-domain]  Cd Length: 254  Bit Score: 40.38  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643  36 PVSVQSMTTtRTSDIGSTLQQIAELTASGCQIVRVAcPTQDDADALATIARKSQIPVIA------DIHFQPKYVFAAIEA 109
Cdd:COG1082    2 KLGLSTYSL-PDLDLEEALRAAAELGYDGVELAGGD-LDEADLAELRAALADHGLEISSlhapglNLAPDPEVREAALER 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 110 -----------GCAAVRVNPG-----------NIKQFDDKVKEIARAAKDHGtpIRIGV--NAGSLDRrllqkygkaTPE 165
Cdd:COG1082   80 lkraidlaaelGAKVVVVHPGsppppdlppeeAWDRLAERLRELAELAEEAG--VTLALenHEGTFVN---------TPE 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648556643 166 ALVEsalweasLFEEHDFRDIKI-------SVKHNDPVVMIEAYRQLAAQ---CDYPLHLGVteagPAFQGTIKSAVAFG 235
Cdd:COG1082  149 EALR-------LLEAVDSPNVGLlldtghaLLAGEDPVELLRKLGDRIKHvhlKDADGDQHL----PPGEGDIDFAAILR 217

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 648556643 236 ALlsQGIGDTIRVSL-----SAPPAEEVKVGLQILESL 268
Cdd:COG1082  218 AL--KEAGYDGWLSLevesdPDDPEEAARESLEYLRKL 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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