|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
7-473 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 711.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 INLTAGSTIRFDTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNVPDV 166
Cdd:COG0469 83 VELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 167 LLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQ---GRAQINLKLEKPLAVEHLTRLTELSDSIMVAR 243
Cdd:COG0469 163 GLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEeagGRAPIIAKIEKPEAVENLDEIIEASDGIMVAR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 244 GDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVEA 323
Cdd:COG0469 243 GDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 324 VAMMDQIIKQVERDPGYRAIIESQRPEEGHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQ 403
Cdd:COG0469 323 VETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTPN 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 404 LSTARRLVMSYGVHVVHAPeEIHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLVTI 473
Cdd:COG0469 403 ERTARRLALVWGVYPVLVD-DVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
4-473 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 656.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 4 RRGRATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFE 83
Cdd:PRK06247 2 KRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 84 NGFINLTAGSTIRFDTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNV 163
Cdd:PRK06247 82 DGKVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 164 PDVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQGRAQINLKLEKPLAVEHLTRLTELSDSIMVAR 243
Cdd:PRK06247 162 PGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVAR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 244 GDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVEA 323
Cdd:PRK06247 242 GDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 324 VAMMDQIIKQVERDPGYRAIIESQRPEEGHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQ 403
Cdd:PRK06247 322 VRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTPN 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 404 LSTARRLVMSYGVHVVHAPeEIHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLVTI 473
Cdd:PRK06247 402 PETARRLALTWGVHCVVVD-DARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
7-470 |
1.41e-174 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 499.88 E-value: 1.41e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 INLTAGSTIRFDTDPTP--GNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNVP 164
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKgeGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 165 DVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQ----GRAQINLKLEKPLAVEHLTRLTELSDSIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGekgaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 241 VARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 321 VEAVAMMDQIIKQVERDPGYRAIIESQRPEEGH--SVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPII 398
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKpsTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648599625 399 GIASQLSTARRLVMSYGVHVVHAPEEIHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRL 470
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
7-473 |
2.56e-155 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 451.38 E-value: 2.56e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 -INLTAGSTIRFDTDPTP--GNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGY-IDAEVVAGNKLSNNKGFN 162
Cdd:cd00288 82 dISLKAGDKFLVTTDPAAkkGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 163 VPDVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQG---RAQINLKLEKPLAVEHLTRLTELSDSI 239
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEkgkDIKIIAKIENQEGVNNFDEILEASDGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 240 MVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQY 319
Cdd:cd00288 242 MVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 320 PVEAVAMMDQIIKQVERDPGYRAIIESQRPEE--GHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPI 397
Cdd:cd00288 322 PVEAVKAMARICLEAEKALSHRVLFNEMRRLTprPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 398 IGIASQLSTARRLVMSYGVHVVHAPEEIHTFGE----MAAKATQVTVEHGFATEGDLIAITAGVPFATpGTTNVLRLVTI 473
Cdd:cd00288 402 IAVTRNEQTARQLHLYRGVYPVLFEEPKPGWQEdtdaRLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRILTV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
7-343 |
9.58e-118 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 350.51 E-value: 9.58e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 --INLTAGSTIRFDTDP---TPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKG-AGYIDAEVVAGNKLSNNKG 160
Cdd:pfam00224 82 kdIELKAGDEMIVSTDAkykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDdDKTLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 161 FNVPDVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQG---RAQINLKLEKPLAVEHLTRLTELSD 237
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEagkNIQIIAKIENQEGVNNFDEILEATD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 238 SIMVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAG 317
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321
|
330 340
....*....|....*....|....*.
gi 648599625 318 QYPVEAVAMMDQIIKQVERDPGYRAI 343
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALPHRNL 347
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
7-473 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 711.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:COG0469 3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKEGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 INLTAGSTIRFDTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNVPDV 166
Cdd:COG0469 83 VELKKGDTFTLTTDDVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVNLPGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 167 LLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQ---GRAQINLKLEKPLAVEHLTRLTELSDSIMVAR 243
Cdd:COG0469 163 GLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEeagGRAPIIAKIEKPEAVENLDEIIEASDGIMVAR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 244 GDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVEA 323
Cdd:COG0469 243 GDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAVGKYPVEA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 324 VAMMDQIIKQVERDPGYRAIIESQRPEEGHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQ 403
Cdd:COG0469 323 VETMARIAEEAEKSLDYRRILDRLRDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRPKVPILALTPN 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 404 LSTARRLVMSYGVHVVHAPeEIHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLVTI 473
Cdd:COG0469 403 ERTARRLALVWGVYPVLVD-DVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
4-473 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 656.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 4 RRGRATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFE 83
Cdd:PRK06247 2 KRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 84 NGFINLTAGSTIRFDTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNV 163
Cdd:PRK06247 82 DGKVQLANGQTFRLDVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGVSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 164 PDVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQGRAQINLKLEKPLAVEHLTRLTELSDSIMVAR 243
Cdd:PRK06247 162 PGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKIEKPQAIDRLEAIVEASDAIMVAR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 244 GDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVEA 323
Cdd:PRK06247 242 GDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETASGKYPVEA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 324 VAMMDQIIKQVERDPGYRAIIESQRPEEGHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQ 403
Cdd:PRK06247 322 VRTMARIIRQVERDPTYPPLIHAQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERPPLPILALTPN 401
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 404 LSTARRLVMSYGVHVVHAPeEIHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLVTI 473
Cdd:PRK06247 402 PETARRLALTWGVHCVVVD-DARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
|
|
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
4-463 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 536.66 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 4 RRGRATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFE 83
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 84 NGFINLTAGSTIRFDTDPT-PGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFN 162
Cdd:PRK05826 81 EGKITLKTGDKFTLDTDQKeEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGIN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 163 VPDVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQ----GRAQINLKLEKPLAVEHLTRLTELSDS 238
Cdd:PRK05826 161 IPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLReagcPHAKIIAKIERAEAVDNIDEIIEASDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 239 IMVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQ 318
Cdd:PRK05826 241 IMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAAGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 319 YPVEAVAMMDQIIKQVERDP---GYRAIIESQRPEEGHSVADAVTQAAYHaalSTNAAAIVTYTLSGTTTLHAARERPRI 395
Cdd:PRK05826 321 YPVEAVEAMARICKGAEKEFsinLSKHRLDRQFDRIDEAIAMSAMYAANH---LKGVKAIVALTESGRTARLISRFRPGA 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648599625 396 PIIGIASQLSTARRLVMSYGVHVVHAPEEiHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPG 463
Cdd:PRK05826 398 PIFAVTRDEKTQRRLALYRGVYPVLFDSA-ADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
7-478 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 522.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:PRK06354 8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRLGRFEDGP 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 INLTAGSTIRFDTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRV--VKKGAGYIDAEVVAGNKLSNNKGFNVP 164
Cdd:PRK06354 88 IELKTGDEFILTSREVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVeeVDKADGELHCKVLVGGVLSNKKGVNFP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 165 DVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQGRA----QINLKLEKPLAVEHLTRLTELSDSIM 240
Cdd:PRK06354 168 GVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNgkhiPIIAKIEKQEAIDNIDAILELCDGLM 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 241 VARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYP 320
Cdd:PRK06354 248 VARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVMLSNETAAGDYP 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 321 VEAVAMMDQIIKQVERDPGYRAiIESQRPEEGHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGI 400
Cdd:PRK06354 328 VEAVQTMATIAVRIEKDLPYRD-ILSKRPEFTTTITNAISQAVSHIALQLDAAAIVTLTKSGATARNVSKYRPKTPILAV 406
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648599625 401 ASQLSTARRLVMSYGVHVVHAPEEIHTfGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLVTIDKAMA 478
Cdd:PRK06354 407 TPNESVARRLQLVWGVTPLLVLDAPST-DETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTDLMKVHVVGAVVA 483
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
7-470 |
1.41e-174 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 499.88 E-value: 1.41e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 INLTAGSTIRFDTDPTP--GNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNVP 164
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKgeGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 165 DVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQ----GRAQINLKLEKPLAVEHLTRLTELSDSIM 240
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGekgaKDVKIIAKIENQEGVDNIDEIAEASDGIM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 241 VARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYP 320
Cdd:TIGR01064 241 VARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKGKYP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 321 VEAVAMMDQIIKQVERDPGYRAIIESQRPEEGH--SVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPII 398
Cdd:TIGR01064 321 VEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKpsTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPNAPII 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 648599625 399 GIASQLSTARRLVMSYGVHVVHAPEEIHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRL 470
Cdd:TIGR01064 401 AVTPNERVARQLALYWGVFPFLVDEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
7-473 |
2.56e-155 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 451.38 E-value: 2.56e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:cd00288 2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 -INLTAGSTIRFDTDPTP--GNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGY-IDAEVVAGNKLSNNKGFN 162
Cdd:cd00288 82 dISLKAGDKFLVTTDPAAkkGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGSRKGVN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 163 VPDVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQG---RAQINLKLEKPLAVEHLTRLTELSDSI 239
Cdd:cd00288 162 LPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEkgkDIKIIAKIENQEGVNNFDEILEASDGI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 240 MVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQY 319
Cdd:cd00288 242 MVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKGKY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 320 PVEAVAMMDQIIKQVERDPGYRAIIESQRPEE--GHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPI 397
Cdd:cd00288 322 PVEAVKAMARICLEAEKALSHRVLFNEMRRLTprPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPNAPI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 398 IGIASQLSTARRLVMSYGVHVVHAPEEIHTFGE----MAAKATQVTVEHGFATEGDLIAITAGVPFATpGTTNVLRLVTI 473
Cdd:cd00288 402 IAVTRNEQTARQLHLYRGVYPVLFEEPKPGWQEdtdaRLKAAVNVAKEKGLLKKGDLVVVVQGWPVGS-GSTNTMRILTV 480
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
7-343 |
9.58e-118 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 350.51 E-value: 9.58e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:pfam00224 2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDGK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 --INLTAGSTIRFDTDP---TPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKG-AGYIDAEVVAGNKLSNNKG 160
Cdd:pfam00224 82 kdIELKAGDEMIVSTDAkykGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDdDKTLVVEVLNGGVIGSRKG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 161 FNVPDVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQG---RAQINLKLEKPLAVEHLTRLTELSD 237
Cdd:pfam00224 162 VNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEagkNIQIIAKIENQEGVNNFDEILEATD 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 238 SIMVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAG 317
Cdd:pfam00224 242 GIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAKG 321
|
330 340
....*....|....*....|....*.
gi 648599625 318 QYPVEAVAMMDQIIKQVERDPGYRAI 343
Cdd:pfam00224 322 NYPVEAVRMMHEICLEAEKALPHRNL 347
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
7-466 |
3.61e-117 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 353.59 E-value: 3.61e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGF 86
Cdd:PRK09206 2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGGN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 87 -INLTAGSTIRFDTDPT-PGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNVP 164
Cdd:PRK09206 82 dVSLKAGQTFTFTTDKSvVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKGVNLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 165 DVLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQG----RAQINLKLEKPLAVEHLTRLTELSDSIM 240
Cdd:PRK09206 162 GVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAhggeNIQIISKIENQEGLNNFDEILEASDGIM 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 241 VARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYP 320
Cdd:PRK09206 242 VARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGESAKGKYP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 321 VEAVAMMDQIIKQVerDPGYRAIIESQRPEEGHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGI 400
Cdd:PRK09206 322 LEAVSIMATICERT--DRVMNSRLESNNDNRKLRITEAVCRGAVETAEKLDAPLIVVATQGGKSARSVRKYFPDATILAL 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648599625 401 ASQLSTARRLVMSYGV--HVVhapEEIHTFGEMAAKATQVTVEHGFATEGDLIAITAGVPFATpGTTN 466
Cdd:PRK09206 400 TTNEKTARQLVLSKGVvpQLV---KEIASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPS-GTTN 463
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
5-473 |
4.12e-102 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 316.32 E-value: 4.12e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 5 RGRATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVR-ALEKEVRRPIGVLADLQGPKLRLGRFE 83
Cdd:PTZ00066 36 RQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVReAAKARPNANLGILLDTKGPEIRTGFLK 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 84 NGF-INLTAGSTIRFDTDPT-PGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGF 161
Cdd:PTZ00066 116 NHKpITLKEGQTLKITTDYTfLGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGERKNM 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 162 NVPDVLLPVSALTDKDRADLF-FALDLGVEWIALSFVQRPEDVLEAKELIQGRAQ---INLKLEKPLAVEHLTRLTELSD 237
Cdd:PTZ00066 196 NLPGVKVELPVIGEKDKNDILnFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRhikIIPKIENIEGLINFDEILAESD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 238 SIMVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAG 317
Cdd:PTZ00066 276 GIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETANG 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 318 QYPVEAVAMMDQIIKQVERDPGYRAIIESQRPEEGH--SVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRI 395
Cdd:PTZ00066 356 KFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTpvSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPSC 435
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 648599625 396 PIIGIASQLSTARRLVMSYGVHVVHAPEEIHTFGEMAAkATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLVTI 473
Cdd:PTZ00066 436 TILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRN-AIALAKERGLVESGDSAIAVHGVKEEVAGSSNLMKVVKI 512
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
1-474 |
2.09e-88 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 280.71 E-value: 2.09e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 1 MVSRRGRATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLG 80
Cdd:PLN02461 15 ADGLRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 81 RFENGF-INLTAGSTIRFDTDPT-PGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVK--KGAGYIDAEVVAGNKLS 156
Cdd:PLN02461 95 FLKDGKpVQLKQGQEITITTDYSiKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAMLG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 157 NNKGFNVPDVLLPVSALTDKDRADLffaLDLGV----EWIALSFVQRPEDVLEAKELIQGRA---QINLKLEKPLAVEHL 229
Cdd:PLN02461 175 ERKNVNLPGVVVDLPTLTEKDKEDI---LQWGVpnkiDFIALSFVRKGSDLVEVRKVLGEHAksiLLISKVENQEGLDNF 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 230 TRLTELSDSIMVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVM 309
Cdd:PLN02461 252 DDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVM 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 310 LSAESAAGQYPVEAVAMMDQIIKQVER--DPG--YRAIIESQ----RPEEghSVAdavtQAAYHAALSTNAAAIVTYTLS 381
Cdd:PLN02461 332 LSGETAAGAYPELAVKTMARICREAEAslDYGalFKEIMRSAplpmSPLE--SLA----SSAVRTANKVKASLIVVLTRG 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 382 GTTTLHAARERPRIPIIGIA-------------SQLSTARRLVMSYGVHVVHAPEEIHTFGEMAAK-----ATQVTVEHG 443
Cdd:PLN02461 406 GTTARLVAKYRPAVPILSVVvpeittdsfdwscSDEAPARHSLIYRGLIPVLAEGSAKATDSESTEeileaAIEHAKKKG 485
|
490 500 510
....*....|....*....|....*....|.
gi 648599625 444 FATEGDLIaitagVPFATPGTTNVLRLVTID 474
Cdd:PLN02461 486 LCKPGDSV-----VALHRIGGASVIKILTVK 511
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
12-324 |
5.22e-87 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 271.82 E-value: 5.22e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 12 VATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRrpigVLADLQGPKLRLGRFENGFINLTA 91
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDSIK----ILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 92 GSTIRFDTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNVPDVLLPVS 171
Cdd:PRK06739 82 GDSFILHTQPVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVRLP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 172 ALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQGRAQI--NL--KLEKPLAVEHLTRLTELSDSIMVARGDLG 247
Cdd:PRK06739 162 AITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETspNLiaKIETMEAIENFQDICKEADGIMIARGDLG 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 648599625 248 VELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVEAV 324
Cdd:PRK06739 242 VELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIESV 318
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
33-446 |
6.71e-79 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 254.20 E-value: 6.71e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 33 VDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGFINLTAGSTIRFDTDPT---PGNETRV 109
Cdd:PTZ00300 1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAfadKGTKDKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 110 SIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGY-IDAEVVAGNKLSNNKGFNVP--DVLLPvsALTDKDRADLFFALD 186
Cdd:PTZ00300 81 YIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQtLKCTVTNAHTISDRRGVNLPgcDVDLP--AVSAKDCADLQFGVE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 187 LGVEWIALSFVQRPEDVLEAKELIQGRAQ---INLKLEKPLAVEHLTRLTELSDSIMVARGDLGVELSLPEIPALQKRVI 263
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKGGdimIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 264 RESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVEAVAMMDQIIKQVERDPGYRAI 343
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVF 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 344 IESQRPEEG--HSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQLSTARRLVMSYGVHVVHA 421
Cdd:PTZ00300 319 FNSIKKLQPipMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF 398
|
410 420
....*....|....*....|....*
gi 648599625 422 PEEihTFGEMAAKATQVTVEHGFAT 446
Cdd:PTZ00300 399 DAE--RLGHDEGKEQRVAMGVGFAK 421
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
7-453 |
1.19e-78 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 257.16 E-value: 1.19e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 7 RATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKE-VRRPIGVLADLQGPKLRLGRFENG 85
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQsKDNVIAIMLDTKGPEVRSGDLPQP 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 86 fINLTAGSTIRFDTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVAGNKLSNNKGFNVPD 165
Cdd:PLN02623 190 -IMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNVRG 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 166 VLLPVSALTDKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQG-RAQINL--KLEKPLAVEHLTRLTELSDSIMVA 242
Cdd:PLN02623 269 KSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKScNADIHVivKIESADSIPNLHSIITASDGAMVA 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 243 RGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVE 322
Cdd:PLN02623 349 RGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHGKFPLK 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 323 AVAMMDQIIKQVERD-PGyraiiESQRPEEGHSVADAVTQA-AYHAALSTNA--AAIVTYTLSGTTTLHAARERPRIPII 398
Cdd:PLN02623 429 AVKVMHTVALRTEATlPE-----GTTPPNLGQAFKNHMSEMfAFHATMMANTlgTSIIVFTRTGFMAILLSHYRPSGTIF 503
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 399 GIASQLSTARRLVMSYGVHVVHA-----PEEihTFgemaAKATQVTVEHGFATEGDLIAI 453
Cdd:PLN02623 504 AFTNEKRIQQRLALYQGVCPIYMqfsddAEE--TF----ARALSLLLNKGMVKEGEEVAL 557
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
4-416 |
1.97e-68 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 228.09 E-value: 1.97e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 4 RRGRATKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFe 83
Cdd:PLN02762 22 RSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDL- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 84 NGFINLTA--GS----TIRFDTDPTPgnETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKgagyidaevvAGNKLSN 157
Cdd:PLN02762 101 GGASSAKAedGEewtfTVRKFDGSRP--EFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEK----------IGPDVKC 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 158 NkgFNVPDVLLPVSALT-------------------DKDRADLFFALDLGVEWIALSFVQRPEDVLEAKELIQGRA---Q 215
Cdd:PLN02762 169 K--CTDPGLLLPRANLTfwrdgslvrernamlptisSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSrdsD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 216 INL--KLEKPLAVEHLTRLTELSDSIMVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVATQMLESMISAPVPTRAE 293
Cdd:PLN02762 247 IGViaKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAE 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 294 VSDVATAVYDGADAVMLSAESAAGQYPVEAVAMMDQIIKQVE---RDPGYRAIIEsqRPEEGHSVADAVTQ----AAYHA 366
Cdd:PLN02762 327 VADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMElwsREEKRHEALE--LPQLSSSLSDRISEeicnSAAKM 404
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 648599625 367 ALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQLSTARRLVMSYGV 416
Cdd:PLN02762 405 ANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGL 454
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
9-475 |
2.26e-55 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 193.73 E-value: 2.26e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 9 TKIVATLGPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRFENGFIN 88
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 89 LTAGSTIRFDTDPT-PGNETRVSIPHPEILEALNEGSTVLLD-------------------DGKVRVRVVKKGAgyidae 148
Cdd:PLN02765 110 LKAGNTVTLTPDQSkEASSEVLPINFPGLAKAVKPGDTIFVGqylftgsettsvwlevdevKGDDVVCTVKNSA------ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 149 VVAGNKLSnnkgFNVPDVLLPVSALTDKDRADL-FFALDLGVEWIALSFVQRPEDVLEAKELIQ----GRAQINLKLEKP 223
Cdd:PLN02765 184 TLAGSLFT----LHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSslglSQTQIFAKIENV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 224 LAVEHLTRLTELSDSIMVARGDLGVELSLPEIPALQKRVIRESRRLGKPVIVaTQMLESMISAPVPTRAEVSDVATAVYD 303
Cdd:PLN02765 260 EGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAVLD 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 304 GADAVMLSAESAAGQYPVEAVAMMDQIIKQVER----DPGYRAIIESQRPEEGHsvADAVTQAAYHAALSTNAAAIVTYT 379
Cdd:PLN02765 339 GADAILLGAETLRGLYPVETISTVGRICAEAEKvfnqDLYFKKTVKYVGEPMSH--LESIASSAVRAAIKVKASVIIVFT 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 380 LSGTTTLHAARERPRIPIIGIA-SQLST------------ARRLVMSYGVHVV-----HAPEEIHTFGEMAAKatqVTVE 441
Cdd:PLN02765 417 SSGRAARLIAKYRPTMPVLSVViPRLKTnqlkwsftgafqARQCLIVRGLFPMladprHSAESTSATNESVLK---VALD 493
|
490 500 510
....*....|....*....|....*....|....*...
gi 648599625 442 H----GFATEGDLIAITAGVpfatpGTTNVLRLVTIDK 475
Cdd:PLN02765 494 HgkaaGVIKSHDRVVVCQKV-----GDSSVVKIIELDD 526
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
4-330 |
7.58e-55 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 191.77 E-value: 7.58e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 4 RRGRATKIVATL-GPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLG-- 80
Cdd:PRK08187 130 PAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGav 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 81 RFENGFINLTAGSTIRF----DTDPTPGNETRVSIPHPEILEALNEGSTVLLDDGKVRVRVVKKGAGYIDAEVVA----G 152
Cdd:PRK08187 210 AGPLGKTRLYTGDRLALvaqgPPRRIDEEHFQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHarpkG 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 153 NKLSNNKGFNVPDVLLPVSALTDKDRADLFFAL---DLgvewIALSFVQRPEDV--LEAkELIQGRAQ------INLKLE 221
Cdd:PRK08187 290 LKLKPEKGLNFPDTALDLPALTEKDRADLDFVArhaDL----VGYSFVQSPGDVeaLQA-ALAARRPDdwrklgLVLKIE 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 222 KPLAVEHLTRLT-----ELSDSIMVARGDLGVELSLPEIPALQKRV--IRESRRLgkPVIVATQMLESMISAPVPTRAEV 294
Cdd:PRK08187 365 TPRAVANLPELIvqaagRQPFGVMIARGDLAVEIGFERLAEMQEEIlwLCEAAHV--PVIWATQVLEGLVKKGLPSRAEM 442
|
330 340 350
....*....|....*....|....*....|....*.
gi 648599625 295 SDVATAvyDGADAVMLSaesaAGQYPVEAVAMMDQI 330
Cdd:PRK08187 443 TDAAMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
268-478 |
3.30e-49 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 172.01 E-value: 3.30e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 268 RLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYDGADAVMLSAESAAGQYPVEAVAMMDQIIKQVERDPGYRAIIESQ 347
Cdd:COG3848 4 AAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQRVPR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 348 RPEEGHSVADAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQLSTARRLVMSYGVHVVHAPEEIHT 427
Cdd:COG3848 84 AKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESAST 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 648599625 428 fGEMAAKATQVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLVTIDKAMA 478
Cdd:COG3848 164 -DEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVVGDVLA 213
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
4-336 |
5.03e-43 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 161.66 E-value: 5.03e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 4 RRGRATKIVATL-GPASSSPEMIKALYEAGVDVFRLNFSHGTQENHGRVLASVRALEKEVRRPIGVLADLQGPKLRLGRF 82
Cdd:PRK14725 136 PSGRPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPI 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 83 ENG----------------------------------------------------------------------------- 85
Cdd:PRK14725 216 APGprviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvtevdde 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 86 ------------------------------------FINLTAGSTIRFDTDPTPG-------NETRVSIPHPEILEALNE 122
Cdd:PRK14725 296 gvlaegsqtaylangtllrlgrhdstrvgglppveqKLRLKVGDRLVLTRDDAPGdpaqgdaPPARISCTLPEAFRAARV 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 123 GSTVLLDDGKVRVRVVKKGAGYIDAEVVA----GNKLSNNKGFNVPDVLLPVSALTDKDRADLFFAldlgVEW---IALS 195
Cdd:PRK14725 376 GERVWFDDGKIGAVVVKVEADEVELRITHarpgGSKLKAGKGINLPDSHLPLPALTDKDLEDLAFV----AKHadiVALS 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 196 FVQRPEDV---LEAKELIQGR-AQINLKLEKPLAVEHLTR-LTELSDS----IMVARGDLGVELSLPEIPALQKRVIRES 266
Cdd:PRK14725 452 FVRSPEDVrllLDALEKLGADdLGVVLKIETRRAFENLPRiLLEAMRHprfgVMIARGDLAVEVGFERLAEVQEEILWLC 531
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 267 RRLGKPVIVATQMLESMISAPVPTRAEVSDVATAVYdgADAVMLSaesaAGQYPVEAVAMMDQIIKQVER 336
Cdd:PRK14725 532 EAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEE 595
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
357-471 |
1.69e-33 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 122.97 E-value: 1.69e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 648599625 357 DAVTQAAYHAALSTNAAAIVTYTLSGTTTLHAARERPRIPIIGIASQLSTARRLVMSYGVHVVHAPEEiHTFGEMAAKAT 436
Cdd:pfam02887 1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEA-ETTDEMLRRAV 79
|
90 100 110
....*....|....*....|....*....|....*
gi 648599625 437 QVTVEHGFATEGDLIAITAGVPFATPGTTNVLRLV 471
Cdd:pfam02887 80 KVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| |
