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Conserved domains on  [gi|651313609|ref|WP_026438361|]
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MULTISPECIES: PilZ domain-containing protein [Acinetobacter]

Protein Classification

PilZ domain-containing protein( domain architecture ID 10007091)

PilZ domain-containing protein is involved in binding bis-(3'-5')-cyclic dimeric GMP (c-di-GMP), a ubiquitous second messenger that regulates cell surface-associated traits in bacteria; similar to Xanthomonas citri type IV fimbriae assembly protein

CATH:  2.40.10.220
Gene Ontology:  GO:0035438
PubMed:  30710060|18034161|16920715|31740493
SCOP:  4007748

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilZ COG3215
Type IV pilus assembly protein PilZ [Cell motility, Extracellular structures];
2-113 8.59e-39

Type IV pilus assembly protein PilZ [Cell motility, Extracellular structures];


:

Pssm-ID: 442448  Cd Length: 117  Bit Score: 125.74  E-value: 8.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651313609   2 QPRMGGIIQANIPDVETLYLSYMPYVVGGGLFVPSKQPVKMGEEIFVLATLPEQSQKIPLTGKVIWISQK--QNGiKLQG 79
Cdd:COG3215    5 AARRPGILSLAIKDKAALYAAYMPFLKNGGLFVPTNRPYKLGDEVFLLLTLPDDPEKLPVAGKVVWITPPgaQGG-RPAG 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 651313609  80 FGIQLSGEKGVYYKSEAERILAGLKSDNRNSYTM 113
Cdd:COG3215   84 IGVQFSDDDKEAARNKIEALLAGLLSSDRPTHTM 117
 
Name Accession Description Interval E-value
PilZ COG3215
Type IV pilus assembly protein PilZ [Cell motility, Extracellular structures];
2-113 8.59e-39

Type IV pilus assembly protein PilZ [Cell motility, Extracellular structures];


Pssm-ID: 442448  Cd Length: 117  Bit Score: 125.74  E-value: 8.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651313609   2 QPRMGGIIQANIPDVETLYLSYMPYVVGGGLFVPSKQPVKMGEEIFVLATLPEQSQKIPLTGKVIWISQK--QNGiKLQG 79
Cdd:COG3215    5 AARRPGILSLAIKDKAALYAAYMPFLKNGGLFVPTNRPYKLGDEVFLLLTLPDDPEKLPVAGKVVWITPPgaQGG-RPAG 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 651313609  80 FGIQLSGEKGVYYKSEAERILAGLKSDNRNSYTM 113
Cdd:COG3215   84 IGVQFSDDDKEAARNKIEALLAGLLSSDRPTHTM 117
PilZ pfam07238
PilZ domain; PilZ is a c-di-GMP binding domain found in widespread cytoplasmic receptors, ...
 3-83 2.43e-05

PilZ domain; PilZ is a c-di-GMP binding domain found in widespread cytoplasmic receptors, which is involved in regulation of motility, biofilm formation and virulence of many bacterial pathogens. This domain binds c-di-GMP through RXXXR and [D/N]hSXXG motifs, however, some PilZ domains lack these motifs and do not bind c-di-GMP. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This is the canonical PilZ domain whose structure consists of six beta-strands that form a beta barrel, followed by a long C-terminal alpha-helix.


Pssm-ID: 399904  Cd Length: 102  Bit Score: 40.18  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651313609    3 PRMGGIIQANIPDVETLYLSYMPYVVGGGLFVPSK-QPVKMGEEIFVLATLPEQSQKIPLTGKVIWISQKQNGiklQGFG 81
Cdd:pfam07238   6 PRVPVSLPVTLRDGGGEYKGRLIDISLGGAAIRLPdEPLALGDRVELSLDLLDDGQELALPGRVVRIRPDEDG---ARVG 82


                  ..
gi 651313609   82 IQ 83
Cdd:pfam07238  83 VQ 84
gmx_TIGR02266 TIGR02266
Myxococcus xanthus paralogous domain TIGR02266; This domain is related to Type IV pilus ...
 30-87 3.34e-03

Myxococcus xanthus paralogous domain TIGR02266; This domain is related to Type IV pilus assembly protein PilZ (pfam07238). It is found in at least 12 copies in Myxococcus xanthus DK 1622.


Pssm-ID: 274060  Cd Length: 96  Bit Score: 34.24  E-value: 3.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 651313609   30 GGLFVPSKQPVKMGEEIFVLATLPEQSQKIPLTGKVIWiSQKQNGIKLQGFGIQLSGE 87
Cdd:TIGR02266  27 GGLFIRTRKPLAVGTRVELKLTLPGGERPVELKGVVAW-VRPAADGGPPGMGVRFEDL 83
 
Name Accession Description Interval E-value
PilZ COG3215
Type IV pilus assembly protein PilZ [Cell motility, Extracellular structures];
2-113 8.59e-39

Type IV pilus assembly protein PilZ [Cell motility, Extracellular structures];


Pssm-ID: 442448  Cd Length: 117  Bit Score: 125.74  E-value: 8.59e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651313609   2 QPRMGGIIQANIPDVETLYLSYMPYVVGGGLFVPSKQPVKMGEEIFVLATLPEQSQKIPLTGKVIWISQK--QNGiKLQG 79
Cdd:COG3215    5 AARRPGILSLAIKDKAALYAAYMPFLKNGGLFVPTNRPYKLGDEVFLLLTLPDDPEKLPVAGKVVWITPPgaQGG-RPAG 83

                         90       100       110
                 ....*....|....*....|....*....|....
gi 651313609  80 FGIQLSGEKGVYYKSEAERILAGLKSDNRNSYTM 113
Cdd:COG3215   84 IGVQFSDDDKEAARNKIEALLAGLLSSDRPTHTM 117
PilZ pfam07238
PilZ domain; PilZ is a c-di-GMP binding domain found in widespread cytoplasmic receptors, ...
 3-83 2.43e-05

PilZ domain; PilZ is a c-di-GMP binding domain found in widespread cytoplasmic receptors, which is involved in regulation of motility, biofilm formation and virulence of many bacterial pathogens. This domain binds c-di-GMP through RXXXR and [D/N]hSXXG motifs, however, some PilZ domains lack these motifs and do not bind c-di-GMP. Proteins which contain PilZ are known to interact with the flagellar switch-complex proteins FliG and FliM. This interaction results in a reduction of torque generation and induces CCW motor bias. This is the canonical PilZ domain whose structure consists of six beta-strands that form a beta barrel, followed by a long C-terminal alpha-helix.


Pssm-ID: 399904  Cd Length: 102  Bit Score: 40.18  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651313609    3 PRMGGIIQANIPDVETLYLSYMPYVVGGGLFVPSK-QPVKMGEEIFVLATLPEQSQKIPLTGKVIWISQKQNGiklQGFG 81
Cdd:pfam07238   6 PRVPVSLPVTLRDGGGEYKGRLIDISLGGAAIRLPdEPLALGDRVELSLDLLDDGQELALPGRVVRIRPDEDG---ARVG 82


                  ..
gi 651313609   82 IQ 83
Cdd:pfam07238  83 VQ 84
gmx_TIGR02266 TIGR02266
Myxococcus xanthus paralogous domain TIGR02266; This domain is related to Type IV pilus ...
 30-87 3.34e-03

Myxococcus xanthus paralogous domain TIGR02266; This domain is related to Type IV pilus assembly protein PilZ (pfam07238). It is found in at least 12 copies in Myxococcus xanthus DK 1622.


Pssm-ID: 274060  Cd Length: 96  Bit Score: 34.24  E-value: 3.34e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 651313609   30 GGLFVPSKQPVKMGEEIFVLATLPEQSQKIPLTGKVIWiSQKQNGIKLQGFGIQLSGE 87
Cdd:TIGR02266  27 GGLFIRTRKPLAVGTRVELKLTLPGGERPVELKGVVAW-VRPAADGGPPGMGVRFEDL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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