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Conserved domains on  [gi|651619984|ref|WP_026614079|]
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winged helix-turn-helix domain-containing tetratricopeptide repeat protein [Ensifer aridi]

Protein Classification

winged helix-turn-helix domain-containing tetratricopeptide repeat protein( domain architecture ID 11467125)

winged helix-turn-helix domain-containing tetratricopeptide repeat protein with a TolBN (TolB amino-terminal) domain, may bind DNA and function as a transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
110-241 4.43e-65

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


:

Pssm-ID: 444347  Cd Length: 135  Bit Score: 206.66  E-value: 4.43e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 110 RREPLPLPDKPSIAVLPFVNVSNDSEQESFADGLTEDLITDLSRVSGLFVIARNSAFAYKGKAMDVRAIAEDLGVRYLLE 189
Cdd:COG5616    1 ASPAPAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 651619984 190 GSARRAAGRVRINAQLVDAMSGDHLWAERFDRSLDDIFVVQDEVTGKIVEAL 241
Cdd:COG5616   81 GSVRRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAAL 132
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
5-106 3.87e-33

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


:

Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 121.55  E-value: 3.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   5 RFAFGPFVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLGPAAD 84
Cdd:COG3710    2 RYRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNSLTQAISRLRKALGDDGL 81

                         90       100
                 ....*....|....*....|..
gi 651619984  85 GGQWISTIPRVGYRFAGAVERL 106
Cdd:COG3710   82 EPRLIRTVPRRGYRLVAPVEVE 103
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
278-463 4.37e-19

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.60  E-value: 4.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHWMgwvhsggptEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG0457   25 EEAIEDYEKALELDPDDAEALYNLGLAYLR---------LGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 358 DAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYlTLGQAQYAAGEYEAAVETLRQDETYR 437
Cdd:COG0457   96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALY-NLGIALEKLGRYEEALELLEKLEAAA 174

                        170       180
                 ....*....|....*....|....*.
gi 651619984 438 TSSRRFLAASLAQLGRLDEARAEVEL 463
Cdd:COG0457  175 LAALLAAALGEAALALAAAEVLLALL 200
 
Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
110-241 4.43e-65

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 206.66  E-value: 4.43e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 110 RREPLPLPDKPSIAVLPFVNVSNDSEQESFADGLTEDLITDLSRVSGLFVIARNSAFAYKGKAMDVRAIAEDLGVRYLLE 189
Cdd:COG5616    1 ASPAPAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 651619984 190 GSARRAAGRVRINAQLVDAMSGDHLWAERFDRSLDDIFVVQDEVTGKIVEAL 241
Cdd:COG5616   81 GSVRRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAAL 132
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
5-106 3.87e-33

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 121.55  E-value: 3.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   5 RFAFGPFVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLGPAAD 84
Cdd:COG3710    2 RYRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNSLTQAISRLRKALGDDGL 81

                         90       100
                 ....*....|....*....|..
gi 651619984  85 GGQWISTIPRVGYRFAGAVERL 106
Cdd:COG3710   82 EPRLIRTVPRRGYRLVAPVEVE 103
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
5-403 8.74e-20

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 92.22  E-value: 8.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   5 RFAFGPFVLDSGaGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLGPAAD 84
Cdd:PRK12370  13 KFVFDDFILNMD-GSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIYALRRILSEDKE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  85 gGQWISTIPRVGYRFAGAVERLGgarrEPLPLPDKPSIAVLPF-VNVSNDSEQesfadgLTEDLITDLSRVS--GLFV-- 159
Cdd:PRK12370  92 -HRYIETLYGQGYRFNRPVVVVS----PPAPQPTTHTLAILPFqMQDQVQSES------LHYSIVKGLSQYApfGLSVlp 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 160 --IARNSafaykGKAMDVRAIAEDLGVRYLLEGSARRAAGRVRINAQLVDAMSGDHLWAERFDRSLDD-IFVVQDEVTGK 236
Cdd:PRK12370 161 vtITKNC-----RSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQpASLLQNKIANL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 237 IVEallgrlRTPPPRNRPKNLQAYD------LCVRARKVMDD-SPQMAQEAHLMLRRAVSLDPEYAEAYRWLAINHWMgw 309
Cdd:PRK12370 236 LLR------CIPGLRWDTKQISELNsidstmVYLRGKHELNQyTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLS-- 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 310 VHSGGPTEANRSI--ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGR 387
Cdd:PRK12370 308 MAQMGIFDKQNAMikAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQ 387

                        410
                 ....*....|....*.
gi 651619984 388 VEEGLDHIRKAFRLNP 403
Cdd:PRK12370 388 LEEALQTINECLKLDP 403
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
278-463 4.37e-19

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.60  E-value: 4.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHWMgwvhsggptEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG0457   25 EEAIEDYEKALELDPDDAEALYNLGLAYLR---------LGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 358 DAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYlTLGQAQYAAGEYEAAVETLRQDETYR 437
Cdd:COG0457   96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALY-NLGIALEKLGRYEEALELLEKLEAAA 174

                        170       180
                 ....*....|....*....|....*.
gi 651619984 438 TSSRRFLAASLAQLGRLDEARAEVEL 463
Cdd:COG0457  175 LAALLAAALGEAALALAAAEVLLALL 200
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 11-99 7.58e-16

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 72.51  E-value: 7.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  11 FVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGN-LTVQIALLRKLLGPAAdGGQWI 89
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRtVDVHISRLRKKLEDDP-EPRLI 79

                         90
                 ....*....|
gi 651619984  90 STIPRVGYRF 99
Cdd:cd00383   80 KTVRGVGYRL 89
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 24-99 2.17e-13

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 65.27  E-value: 2.17e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 651619984    24 DDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGT-AVEEGNLTVQIALLRKLLGPAADgGQWISTIPRVGYRF 99
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDeDVDDNTLDVHISRLRKKLEDDGD-PRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
24-99 2.18e-13

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 65.23  E-value: 2.18e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 651619984   24 DDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWP-GTAVEEGNLTVQIALLRKLLGPAADGGQWISTIPRVGYRF 99
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGeDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 291-471 1.03e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  291 DPEYAEAYRWLAINHwmgwVHSGGPTEANRSIALelarkAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPN 370
Cdd:TIGR02917 121 DEGAAELLALRGLAY----LGLGQLELAQKSYEQ-----ALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPG 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  371 EADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFpASWYYLTLGQAQYAAGEYEAA---VETLRQdETYRTSSRRFLAAS 447
Cdd:TIGR02917 192 NVDALLLKGDLLLSLGNIELALAAYRKAIALRPN-NIAVLLALATILIEAGEFEEAekhADALLK-KAPNSPLAHYLKAL 269

                         170       180
                  ....*....|....*....|....*
gi 651619984  448 LA-QLGRLDEARAEVELFLVGNPHF 471
Cdd:TIGR02917 270 VDfQKKNYEDARETLQDALKSAPEY 294
ompR PRK09468
osmolarity response regulator; Provisional
 6-99 4.51e-07

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 51.13  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   6 FAFGPFVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAA----WpgtAVEEGNLTVQIALLRKLLGP 81
Cdd:PRK09468 139 IAFGKFKLNLGTRELFRGDEPMPLTTGEFAVLKALVSHPREPLSRDKLMNLArgreY---SAMERSIDVQISRLRRLIEE 215

                         90
                 ....*....|....*...
gi 651619984  82 AADGGQWISTIPRVGYRF 99
Cdd:PRK09468 216 DPAHPRYIQTVWGLGYVF 233
FlgO pfam17680
FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio ...
 115-211 3.60e-05

FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.


Pssm-ID: 435970  Cd Length: 130  Bit Score: 43.27  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  115 PLPDKPSIAVLPFVNVSNDSEQESFADGLTEDLITDLSRVsGLFVI---ARNS-AFAYKGKAM---DVRAIAEDLGVRYL 187
Cdd:pfam17680  13 PLLLRRPIAVTSFVDLDDLQQTSTLGRQLSESLITELQQR-GYSVVeykLTDSiRVTEEGEFAlsrDLRELAETQNADYV 91

                          90       100
                  ....*....|....*....|....
gi 651619984  188 LEGSARRAAGRVRINAQLVDAMSG 211
Cdd:pfam17680  92 LVGTYTVTRDGVLVNARLIDLKDN 115
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 413-462 1.74e-03

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 37.23  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 651619984  413 LGQAQYAAGEYEAAVETLRQDETYRTSSR-RFLAA-SLAQLGRLDEARAEVE 462
Cdd:pfam12895  29 LAQCLFLNGQYKRAYELLRKAKLNGSSLGcRYLFAqCLLKLKKYDEALDALG 80
 
Name Accession Description Interval E-value
TolBN COG5616
TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];
110-241 4.43e-65

TolB amino-terminal domain (function unknown) [Signal transduction mechanisms];


Pssm-ID: 444347  Cd Length: 135  Bit Score: 206.66  E-value: 4.43e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 110 RREPLPLPDKPSIAVLPFVNVSNDSEQESFADGLTEDLITDLSRVSGLFVIARNSAFAYKGKAMDVRAIAEDLGVRYLLE 189
Cdd:COG5616    1 ASPAPAAPDRPSIAVLPFENLSGDPEQEYFADGLTEELITALSRLRGLRVIARTSSFAFKGRAVDLREIARELGVRYVLE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 651619984 190 GSARRAAGRVRINAQLVDAMSGDHLWAERFDRSLDDIFVVQDEVTGKIVEAL 241
Cdd:COG5616   81 GSVRRSGDRVRVTAQLIDAATGRHLWSERYDRDLDDLFALQDEIARAIAAAL 132
CadC1 COG3710
DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];
5-106 3.87e-33

DNA-binding winged helix-turn-helix (wHTH) domain [Transcription];


Pssm-ID: 442924 [Multi-domain]  Cd Length: 106  Bit Score: 121.55  E-value: 3.87e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   5 RFAFGPFVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLGPAAD 84
Cdd:COG3710    2 RYRFGDFRLDPARRELLRDGEPVRLSPRAFDLLLLLLEHPGRVVSRDELLAAVWPGRVVSDNSLTQAISRLRKALGDDGL 81

                         90       100
                 ....*....|....*....|..
gi 651619984  85 GGQWISTIPRVGYRFAGAVERL 106
Cdd:COG3710   82 EPRLIRTVPRRGYRLVAPVEVE 103
PRK12370 PRK12370
HilA/EilA family virulence transcriptional regulator;
5-403 8.74e-20

HilA/EilA family virulence transcriptional regulator;


Pssm-ID: 237080 [Multi-domain]  Cd Length: 553  Bit Score: 92.22  E-value: 8.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   5 RFAFGPFVLDSGaGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLGPAAD 84
Cdd:PRK12370  13 KFVFDDFILNMD-GSLLRSEKKVNIPPKEYAVLVILLEAAGEIVSKNTLLDQVWGDAEVNEESLTRCIYALRRILSEDKE 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  85 gGQWISTIPRVGYRFAGAVERLGgarrEPLPLPDKPSIAVLPF-VNVSNDSEQesfadgLTEDLITDLSRVS--GLFV-- 159
Cdd:PRK12370  92 -HRYIETLYGQGYRFNRPVVVVS----PPAPQPTTHTLAILPFqMQDQVQSES------LHYSIVKGLSQYApfGLSVlp 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 160 --IARNSafaykGKAMDVRAIAEDLGVRYLLEGSARRAAGRVRINAQLVDAMSGDHLWAERFDRSLDD-IFVVQDEVTGK 236
Cdd:PRK12370 161 vtITKNC-----RSVKDILELMDQLRPDYYISGQMIPDGNDNIVQIEIVRVKGYHLLHQESIKLIEHQpASLLQNKIANL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 237 IVEallgrlRTPPPRNRPKNLQAYD------LCVRARKVMDD-SPQMAQEAHLMLRRAVSLDPEYAEAYRWLAINHWMgw 309
Cdd:PRK12370 236 LLR------CIPGLRWDTKQISELNsidstmVYLRGKHELNQyTPYSLQQALKLLTQCVNMSPNSIAPYCALAECYLS-- 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 310 VHSGGPTEANRSI--ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGR 387
Cdd:PRK12370 308 MAQMGIFDKQNAMikAKEHAIKATELDHNNPQALGLLGLINTIHSEYIVGSLLFKQANLLSPISADIKYYYGWNLFMAGQ 387

                        410
                 ....*....|....*.
gi 651619984 388 VEEGLDHIRKAFRLNP 403
Cdd:PRK12370 388 LEEALQTINECLKLDP 403
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
278-463 4.37e-19

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 86.60  E-value: 4.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHWMgwvhsggptEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG0457   25 EEAIEDYEKALELDPDDAEALYNLGLAYLR---------LGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 358 DAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYlTLGQAQYAAGEYEAAVETLRQDETYR 437
Cdd:COG0457   96 LEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALY-NLGIALEKLGRYEEALELLEKLEAAA 174

                        170       180
                 ....*....|....*....|....*.
gi 651619984 438 TSSRRFLAASLAQLGRLDEARAEVEL 463
Cdd:COG0457  175 LAALLAAALGEAALALAAAEVLLALL 200
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
288-462 2.31e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 81.59  E-value: 2.31e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 288 VSLDPEYAEAYRWLAINHWMgwvhSGGPTEanrsiALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIEL 367
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRR----LGRYEE-----AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 368 DPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYlTLGQAQYAAGEYEAAVETLRQ---DETYRTSSRRFL 444
Cdd:COG0457   72 DPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALY-NLGLALLELGRYDEAIEAYERaleLDPDDADALYNL 150

                        170
                 ....*....|....*...
gi 651619984 445 AASLAQLGRLDEARAEVE 462
Cdd:COG0457  151 GIALEKLGRYEEALELLE 168
trans_reg_C cd00383
DNA-binding effector domain of two-component system response regulators; Bacteria and some ...
 11-99 7.58e-16

DNA-binding effector domain of two-component system response regulators; Bacteria and some eukaryotes use two-component signal transduction systems to detect and respond to changes in the environment. The systems consists of a sensor histidine kinase and a response regulator. The former autophosphorylates a histidine residue on detecting an external stimulus. The phosphate is then transferred to an invariant aspartate residue in a highly conserved receiver domain of the response regulator. Phosphorylation activates a variable effector domain of the response regulator, which triggers the cellular response. This C-terminal effector domain belongs to the winged helix-turn-helix family of transcriptional regulators and contains DNA and RNA polymerase binding sites. Several dimers or monomers bind head to tail to small tandem repeats upstream of the genes. The RNA polymerase binding sites interact with the alpha or sigma subunit of RNA polymerase.


Pssm-ID: 294013 [Multi-domain]  Cd Length: 89  Bit Score: 72.51  E-value: 7.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  11 FVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGN-LTVQIALLRKLLGPAAdGGQWI 89
Cdd:cd00383    1 LRLDPARREVTVDGEEVELTPKEFELLELLARNPGRVVSREELLEAVWGYDYEVDDRtVDVHISRLRKKLEDDP-EPRLI 79

                         90
                 ....*....|
gi 651619984  90 STIPRVGYRF 99
Cdd:cd00383   80 KTVRGVGYRL 89
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 278-462 1.13e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.08  E-value: 1.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHwmgwvhsggptEANRSI--ALELARKAVALDPNDAGCRWVLAYLLAYERSFA 355
Cdd:COG2956   93 DRAEELLEKLLELDPDDAEALRLLAEIY-----------EQEGDWekAIEVLERLLKLGPENAHAYCELAELYLEQGDYD 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 356 EADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYLtLGQAQYAAGEYEAAVETLRQ--D 433
Cdd:COG2956  162 EAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPR-LAELYEKLGDPEEALELLRKalE 240

                        170       180
                 ....*....|....*....|....*....
gi 651619984 434 ETYRTSSRRFLAASLAQLGRLDEARAEVE 462
Cdd:COG2956  241 LDPSDDLLLALADLLERKEGLEAALALLE 269
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 323-451 1.49e-15

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 73.12  E-value: 1.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLN 402
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 651619984 403 P-FPASWYYltLGQAQYAAGEYEAAVETLRQ--DETYRTSSRRFLAASLAQL 451
Cdd:COG4235   82 PdNPEALYL--LGLAAFQQGDYAEAIAAWQKllALLPADAPARLLEASIAEA 131
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 323-502 4.35e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 74.64  E-value: 4.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLN 402
Cdd:COG3914   97 ALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELD 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 403 PFPASWYYLtLGQAQYAAGEYEAAVETLRQ-------DETYRTS--SRRFLAASLAQLGRLDEARAEVELFLVGNPHFTI 473
Cdd:COG3914  177 PDNAEALNN-LGNALQDLGRLEEAIAAYRRaleldpdNADAHSNllFALRQACDWEVYDRFEELLAALARGPSELSPFAL 255

                        170       180
                 ....*....|....*....|....*....
gi 651619984 474 RHWATTEPFRHAATLEHFVDGFRKAGLPE 502
Cdd:COG3914  256 LYLPDDDPAELLALARAWAQLVAAAAAPE 284
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 283-462 4.66e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.45  E-value: 4.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 283 MLRRAVSLDPEYAEAYRWLAINHWMgwvhsggptEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFA 362
Cdd:COG2956   64 IHQKLLERDPDRAEALLELAQDYLK---------AGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 363 KAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASwYYLTLGQAQYAAGEYEAAVETLRQ---DETYRTS 439
Cdd:COG2956  135 RLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCAR-ALLLLAELYLEQGDYEEAIAALERaleQDPDYLP 213

                        170       180
                 ....*....|....*....|...
gi 651619984 440 SRRFLAASLAQLGRLDEARAEVE 462
Cdd:COG2956  214 ALPRLAELYEKLGDPEEALELLR 236
Trans_reg_C smart00862
Transcriptional regulatory protein, C terminal; This domain is almost always found associated ...
 24-99 2.17e-13

Transcriptional regulatory protein, C terminal; This domain is almost always found associated with the response regulator receiver domain. It may play a role in DNA binding.


Pssm-ID: 214866 [Multi-domain]  Cd Length: 76  Bit Score: 65.27  E-value: 2.17e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 651619984    24 DDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGT-AVEEGNLTVQIALLRKLLGPAADgGQWISTIPRVGYRF 99
Cdd:smart00862   1 GEPIKLTPKEFRLLELLLRNPGRVVSREELLEAVWGDDeDVDDNTLDVHISRLRKKLEDDGD-PRLIETVRGVGYRL 76
Trans_reg_C pfam00486
Transcriptional regulatory protein, C terminal;
24-99 2.18e-13

Transcriptional regulatory protein, C terminal;


Pssm-ID: 425712 [Multi-domain]  Cd Length: 77  Bit Score: 65.23  E-value: 2.18e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 651619984   24 DDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWP-GTAVEEGNLTVQIALLRKLLGPAADGGQWISTIPRVGYRF 99
Cdd:pfam00486   1 GEEVELTPKEFKLLELLAENPGRVVSREQLLEEVWGeDYDVDDNTVDVHISRLRKKLEDDPRDPRLIKTVRGVGYRL 77
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 323-432 2.97e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 66.75  E-value: 2.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLN 402
Cdd:COG4783   23 AEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLD 102

                         90       100       110
                 ....*....|....*....|....*....|
gi 651619984 403 PFPASWYYLtLGQAQYAAGEYEAAVETLRQ 432
Cdd:COG4783  103 PEHPEAYLR-LARAYRALGRPDEAIAALEK 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
331-471 4.17e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 4.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 331 VALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNP-FPASWY 409
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPdDAEALN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 651619984 410 YltLGQAQYAAGEYEAAVETLRQ---DETYRTSSRRFLAASLAQLGRLDEARAEVELFLVGNPHF 471
Cdd:COG0457   81 N--LGLALQALGRYEEALEDYDKaleLDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDD 143
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
278-465 5.03e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.88  E-value: 5.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHWmgwvHSGGPTEAnrsiaLELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG0457   59 EEALADYEQALELDPDDAEALNNLGLALQ----ALGRYEEA-----LEDYDKALELDPDDAEALYNLGLALLELGRYDEA 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 358 DAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYLTLGQAQYAAGEYEAAVETLRQDETYR 437
Cdd:COG0457  130 IEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRK 209

                        170       180
                 ....*....|....*....|....*...
gi 651619984 438 TSSRRFLAASLAQLGRLDEARAEVELFL 465
Cdd:COG0457  210 KLAILTLAALAELLLLALALLLALRLAA 237
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 284-471 8.18e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 68.60  E-value: 8.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 284 LRRAVSLDPEYAEAYRWLAINHWMgwvhSGGPTEAnrsiaLELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAK 363
Cdd:COG2956   31 LEEALELDPETVEAHLALGNLYRR----RGEYDRA-----IRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 364 AIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYLtLGQAQYAAGEYEAAVETLRQ-DETYRTSSR- 441
Cdd:COG2956  102 LLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCE-LAELYLEQGDYDEAIEALEKaLKLDPDCARa 180

                        170       180       190
                 ....*....|....*....|....*....|.
gi 651619984 442 -RFLAASLAQLGRLDEARAEVELFLVGNPHF 471
Cdd:COG2956  181 lLLLAELYLEQGDYEEAIAALERALEQDPDY 211
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-471 9.42e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 70.41  E-value: 9.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 275 QMAQEAHLMLRRAVSLDPEYAEAYRWLAINHWMGWVHSGGPTEANRSIALELARKAVALDPNDAGCRWVLAYLLAYE--- 351
Cdd:COG3914    8 ALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAall 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 352 ----RSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYLtLGQAQYAAGEYEAAV 427
Cdd:COG3914   88 lqalGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLN-LGEALRRLGRLEEAI 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 651619984 428 ETLRQ----DETYRTSSRRfLAASLAQLGRLDEARAEVELFLVGNPHF 471
Cdd:COG3914  167 AALRRalelDPDNAEALNN-LGNALQDLGRLEEAIAAYRRALELDPDN 213
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 344-471 9.65e-13

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.60  E-value: 9.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 344 LAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFpASWYYLTLGQAQYAAGEY 423
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD-EPEARLNLGLALLKAGDY 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 651619984 424 EAAVETLRQ---DETYRTSSRRFLAASLAQLGRLDEARAEVELFLVGNPHF 471
Cdd:COG4783   89 DEALALLEKalkLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 277-403 3.59e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 63.67  E-value: 3.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 277 AQEAHLMLRRAVSLDPEYAEAYRWLAinhwMGWVHSGGPTEAnrsiaLELARKAVALDPNDAGCRWVLAYLLAYERSFAE 356
Cdd:COG4783   20 YDEAEALLEKALELDPDNPEAFALLG----EILLQLGDLDEA-----IVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 651619984 357 ADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNP 403
Cdd:COG4783   91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 278-432 1.71e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 1.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHWMgwvhsggptEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG2956  127 EKAIEVLERLLKLGPENAHAYCELAELYLE---------QGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEA 197

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 651619984 358 DAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASwyYLTLGQAQYAAGEYEAAVETLRQ 432
Cdd:COG2956  198 IAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDL--LLALADLLERKEGLEAALALLER 270
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
323-403 5.19e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 56.33  E-value: 5.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEAdAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLN 402
Cdd:COG3063   11 AEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELD 89


                 .
gi 651619984 403 P 403
Cdd:COG3063   90 P 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 356-469 1.09e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 56.55  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 356 EADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASwYYLTLGQAQYAAGEYEAAVETLRQ--- 432
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNAD-ALLDLAEALLAAGDTEEAEELLERala 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 651619984 433 -DETYrTSSRRFLAASLAQLGRLDEARAEVELFLVGNP 469
Cdd:COG4235   80 lDPDN-PEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 251-381 2.63e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.40  E-value: 2.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 251 RNRPKNLQAYDLCVRARKVMDDspqmAQEAHLMLRRAVSLDPEYAEAYRWLAINHwmgwVHSGGPTEanrsiALELARKA 330
Cdd:COG4235   11 AANPNDAEGWLLLGRAYLRLGR----YDEALAAYEKALRLDPDNADALLDLAEAL----LAAGDTEE-----AEELLERA 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 651619984 331 VALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDI 381
Cdd:COG4235   78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASI 128
PRK10153 PRK10153
DNA-binding transcriptional activator CadC; Provisional
 1-367 2.88e-09

DNA-binding transcriptional activator CadC; Provisional


Pssm-ID: 236658 [Multi-domain]  Cd Length: 517  Bit Score: 59.29  E-value: 2.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   1 MRGSRFAFGPFVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLg 80
Cdd:PRK10153   1 MQQPVFRIGEWLVTPSENKISRQGREVTLEPRLIDLLVFFAQHSGEVLSRDELIDHVWDRAIVTDHVVTQSISELRKSL- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  81 paADGG----QWISTIPRVGYRFAGAVERLGGARREPLPLPDKPS----------------------------------- 121
Cdd:PRK10153  80 --KDGRednpEYIVTVPKRGYKLVAPVIWYSEEEGEEILASSPPPipeavpataepsesanaqfpappltravcqspaks 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 122 ---------------------IAVLPFV--------------------------NVSNDSEQESFADGLTEDLITDLSRV 154
Cdd:PRK10153 158 krfttfwvwrlfllslgicvlLVAMSSLtyrqpvvkirqllnprdidfrfqngnSCNNWSSQLSYADGIGQLLMADLNTV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 155 SGlFVIARNSAFAYKGKAMDVRAIAEDLGVRyllegsARRAAGRVRINAQLVDAMSGDHLWAERFDRSLDDIFVVQDEVT 234
Cdd:PRK10153 238 ST-FVVHDKTNYNINEPSSSGKTLGIAFVNQ------RHYRAQQCFLSVELVDNADGSVMLSKRYFLTNGNQLSVQNDLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 235 GKIVEAL----LGRLRTPPPRNRPKNLQAYDLCVRARK-VMDDSPQMAQEAHLMLRRAVSLDPE--YAEAYRWLAINhwm 307
Cdd:PRK10153 311 NSLSRALnqpwPERMQERLQQGLPHQGAALTLFYQAHHyLNSGDAKSLNKASDLLEEILKSEPDftYAQAEKALADI--- 387

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 651619984 308 gWVHSGGPTEANRSIAL--ELARKAVALDPNDAGCRW-VLAYLLAYERSFAEADAEFAKAIEL 367
Cdd:PRK10153 388 -VRHSQQPLDEKQLAALstELDNIVALPELNVLPRIYeILAVQALVKGKTDEAYQAINKAIDL 449
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 285-432 8.59e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.58  E-value: 8.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 285 RRAVSLDPEYAEAYRWLAINHWMGWVHSGGPTEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKA 364
Cdd:COG5010    1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 651619984 365 IELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYLtLGQAQYAAGEYEAAVETLRQ 432
Cdd:COG5010   81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSN-LAALLLSLGQDDEAKAALQR 147
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 291-471 1.03e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  291 DPEYAEAYRWLAINHwmgwVHSGGPTEANRSIALelarkAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPN 370
Cdd:TIGR02917 121 DEGAAELLALRGLAY----LGLGQLELAQKSYEQ-----ALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPG 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  371 EADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFpASWYYLTLGQAQYAAGEYEAA---VETLRQdETYRTSSRRFLAAS 447
Cdd:TIGR02917 192 NVDALLLKGDLLLSLGNIELALAAYRKAIALRPN-NIAVLLALATILIEAGEFEEAekhADALLK-KAPNSPLAHYLKAL 269

                         170       180
                  ....*....|....*....|....*
gi 651619984  448 LA-QLGRLDEARAEVELFLVGNPHF 471
Cdd:TIGR02917 270 VDfQKKNYEDARETLQDALKSAPEY 294
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 323-471 1.32e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.89  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLN 402
Cdd:COG2956   27 AIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELD 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 651619984 403 PFPASWYYLtLGQAQYAAGEYEAAVETLRQDETYRTSSRRF---LAASLAQLGRLDEARAEVELFLVGNPHF 471
Cdd:COG2956  107 PDDAEALRL-LAEIYEQEGDWEKAIEVLERLLKLGPENAHAyceLAELYLEQGDYDEAIEALEKALKLDPDC 177
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 319-469 1.55e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.40  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  319 NRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKA 398
Cdd:TIGR02917 208 NIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQDA 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 651619984  399 FRLNP-FPASWYYLtlGQAQYAAGEYEAAVETLRQDETYRTSS---RRFLAASLAQLGRLDEARAEVELFLVGNP 469
Cdd:TIGR02917 288 LKSAPeYLPALLLA--GASEYQLGNLEQAYQYLNQILKYAPNShqaRRLLASIQLRLGRVDEAIATLSPALGLDP 360
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 330-472 4.89e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 55.86  E-value: 4.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  330 AVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWY 409
Cdd:TIGR02917  48 ALQKDPNDAEARFLLGKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKFQQVLDELPGKTLLDDEGAAEL 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 651619984  410 YLTLGQAQYAAGEYEAA---VETLRQDETYRTSSRRFLAASLAQLGRLDEARAEVELFLVGNPHFT 472
Cdd:TIGR02917 128 LALRGLAYLGLGQLELAqksYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNV 193
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 323-403 1.02e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.50  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLN 402
Cdd:COG5010   73 SLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152


                 .
gi 651619984 403 P 403
Cdd:COG5010  153 P 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 344-462 3.24e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 344 LAYLLayERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPfPASWYYLTLGQAQYAAGEY 423
Cdd:COG2956   16 LNYLL--NGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDP-DRAEALLELAQDYLKAGLL 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 651619984 424 EAAVETLRQ---DETYRTSSRRFLAASLAQLGRLDEARAEVE 462
Cdd:COG2956   93 DRAEELLEKlleLDPDDAEALRLLAEIYEQEGDWEKAIEVLE 134
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
354-432 3.47e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 48.24  E-value: 3.47e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 651619984 354 FAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDhIRKAFRLNPFPAsWYYLTLGQAQYAAGEYEAAVETLRQ 432
Cdd:COG3063    8 LEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNA-EALLNLAELLLELGDYDEALAYLER 84
ompR PRK09468
osmolarity response regulator; Provisional
 6-99 4.51e-07

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 51.13  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   6 FAFGPFVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAA----WpgtAVEEGNLTVQIALLRKLLGP 81
Cdd:PRK09468 139 IAFGKFKLNLGTRELFRGDEPMPLTTGEFAVLKALVSHPREPLSRDKLMNLArgreY---SAMERSIDVQISRLRRLIEE 215

                         90
                 ....*....|....*...
gi 651619984  82 AADGGQWISTIPRVGYRF 99
Cdd:PRK09468 216 DPAHPRYIQTVWGLGYVF 233
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 278-470 6.29e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.01  E-value: 6.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  278 QEAHLMLRRAVSLDPEYAEAYRWLAinhwMGWVHSGGPTEANRSIAlelarKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:TIGR02917 312 EQAYQYLNQILKYAPNSHQARRLLA----SIQLRLGRVDEAIATLS-----PALGLDPDDPAALSLLGEAYLALGDFEKA 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  358 DAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFP------------------------ASWY---- 409
Cdd:TIGR02917 383 AEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELgradlllilsylrsgqfdkalaaaKKLEkkqp 462

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 651619984  410 -----YLTLGQAQYAAGEYEAAVETLRQDetyRTSSRRFLAA--SLAQL----GRLDEARAEVELFLVGNPH 470
Cdd:TIGR02917 463 dnaslHNLLGAIYLGKGDLAKAREAFEKA---LSIEPDFFPAaaNLARIdiqeGNPDDAIQRFEKVLTIDPK 531
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
344-432 6.71e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 50.30  E-value: 6.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 344 LAYLLAYERSFAEADaeFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPfPASWYYLTLGQAQYAAGEY 423
Cdd:COG4785   81 VAYDSLGDYDLAIAD--FDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDP-DYAYAYLNRGIALYYLGRY 157


                 ....*....
gi 651619984 424 EAAVETLRQ 432
Cdd:COG4785  158 ELAIADLEK 166
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 278-371 9.18e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.26  E-value: 9.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHwmgwVHSGGPTEAnrsiaLELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG4783   55 DEAIVLLHEALELDPDEPEARLNLGLAL----LKAGDYDEA-----LALLEKALKLDPEHPEAYLRLARAYRALGRPDEA 125

                         90
                 ....*....|....
gi 651619984 358 DAEFAKAIELDPNE 371
Cdd:COG4783  126 IAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
278-370 1.23e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.70  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHWMgwvhSGGPTEAnrsialELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG3063    9 EEAEEYYEKALELDPDNADALNNLGLLLLE----QGRYDEA------IALEKALKLDPNNAEALLNLAELLLELGDYDEA 78

                         90
                 ....*....|...
gi 651619984 358 DAEFAKAIELDPN 370
Cdd:COG3063   79 LAYLERALELDPS 91
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
284-428 1.60e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.14  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 284 LRRAVSLDPEYAEAYRWLAINhwmgWVHSGGPTEAnrsiaLELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAK 363
Cdd:COG4785   96 FDQALELDPDLAEAYNNRGLA----YLLLGDYDAA-----LEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEK 166

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 651619984 364 AIELDPNEADTWAALsditvlaGRVEEGLDHIRKAFRLNPFPAsWYYLTLGQAQYAAGEYEAAVE 428
Cdd:COG4785  167 ALELDPNDPERALWL-------YLAERKLDPEKALALLLEDWA-TAYLLQGDTEEARELFKLALA 223
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 2-81 1.77e-06

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 48.80  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   2 RGSRFAFGPFvLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLGP 81
Cdd:COG0745  121 AAEVLRVGDL-LDLAAREVTRDGEPVELTPKEFRLLELLMRNPGRVVSREQLLEEVWGYDYGDDRTVDVHISRLRKKLED 199
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
355-471 3.94e-06

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 48.34  E-value: 3.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 355 AEADAEFAkaieldpNEADTWAALSDITVLAGRVEEGLDHIRKAFRlNPFPASWYYLT-LGQAQYAAGEYEAAVETL--- 430
Cdd:COG4700   79 LEKALEFA-------DTVQNRVRLADALLELGRYDEAIELYEEALT-GIFADDPHILLgLAQALFELGRYAEALETLekl 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 651619984 431 -RQDETYRTSSRRFLAA-SLAQLGRLDEARAEVELFLVGNPHF 471
Cdd:COG4700  151 iAKNPDFKSSDAHLLYArALEALGDLEAAEAELEALARRYSGP 193
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 312-462 1.26e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  312 SGGPTEANRSIALELARkavalDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEAdtwAALSDITVLAGRVE-- 389
Cdd:TIGR02917 749 SGNTAEAVKTLEAWLKT-----HPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNA---VVLNNLAWLYLELKdp 820

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 651619984  390 EGLDHIRKAFRLNP-FPASwyYLTLGQAQYAAGEYEAAVETLRQDETYRTSS---RRFLAASLAQLGRLDEARAEVE 462
Cdd:TIGR02917 821 RALEYAERALKLAPnIPAI--LDTLGWLLVEKGEADRALPLLRKAVNIAPEAaaiRYHLALALLATGRKAEARKELD 895
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 320-469 1.59e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.95  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 320 RSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAF 399
Cdd:COG5010    2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 651619984 400 RLNPFPASwYYLTLGQAQYAAGEYEAAVETLRQ---DETYRTSSRRFLAASLAQLGRLDEARAEVELFLVGNP 469
Cdd:COG5010   82 QLDPNNPE-LYYNLALLYSRSGDKDEAKEYYEKalaLSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 278-370 2.72e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 46.90  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  278 QEAHLMLRRAVSLDPEYAEAYRWLA-INhwmgwVHSGGPTEANrsialELARKAVALDPNDAGCRWVLAYLLAYERSFAE 356
Cdd:TIGR00990 348 LEALADLSKSIELDPRVTQSYIKRAsMN-----LELGDPDKAE-----EDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQ 417

                          90
                  ....*....|....
gi 651619984  357 ADAEFAKAIELDPN 370
Cdd:TIGR00990 418 AGKDYQKSIDLDPD 431
FlgO pfam17680
FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio ...
 115-211 3.60e-05

FlgO protein; This entry represents the FlgO protein. Mutation of this protein in Vibrio cholerae has been shown to reduce motility. FlgO is an outer membrane protein that localizes throughout the membrane and not at the flagellar pole. Although FlgO and FlgP do not specifically localize to the flagellum, they are required for flagellar stability. Proteins in this family mostly contain an N-terminal lipoprotein attachment motif.


Pssm-ID: 435970  Cd Length: 130  Bit Score: 43.27  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  115 PLPDKPSIAVLPFVNVSNDSEQESFADGLTEDLITDLSRVsGLFVI---ARNS-AFAYKGKAM---DVRAIAEDLGVRYL 187
Cdd:pfam17680  13 PLLLRRPIAVTSFVDLDDLQQTSTLGRQLSESLITELQQR-GYSVVeykLTDSiRVTEEGEFAlsrDLRELAETQNADYV 91

                          90       100
                  ....*....|....*....|....
gi 651619984  188 LEGSARRAAGRVRINAQLVDAMSG 211
Cdd:pfam17680  92 LVGTYTVTRDGVLVNARLIDLKDN 115
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 323-465 9.38e-05

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 43.87  E-value: 9.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADtwaALSDI-TVLA--GRVEEGLDHIRKAF 399
Cdd:TIGR02521  50 AKENLDKALEHDPDDYLAYLALALYYQQLGELEKAEDSFRRALTLNPNNGD---VLNNYgTFLCqqGKYEQAMQQFEQAI 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 651619984  400 RLNPFPASW-YYLTLGQAQYAAGEYEAAVETLRQDETY-RTSSRRFLaaSLAQLGRLDEARAEVELFL 465
Cdd:TIGR02521 127 EDPLYPQPArSLENAGLCALKAGDFDKAEKYLTRALQIdPQRPESLL--ELAELYYLRGQYKDARAYL 192
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 278-369 1.55e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 278 QEAHLMLRRAVSLDPEYAEAYRWLAINHWMgwvhsggptEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEA 357
Cdd:COG5010   71 EESLALLEQALQLDPNNPELYYNLALLYSR---------SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEA 141

                         90
                 ....*....|..
gi 651619984 358 DAEFAKAIELDP 369
Cdd:COG5010  142 KAALQRALGTSP 153
TolB_N pfam04052
TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent ...
 108-211 3.31e-04

TolB amino-terminal domain; TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain.


Pssm-ID: 461148  Cd Length: 105  Bit Score: 39.91  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  108 GARREPLPlpdkpsIAVLPFVNVSNDSEQESFADGLTEDLitdlsRVSGLF-VIARNSAFAYKGKAMDVRAIA-EDLGVR 185
Cdd:pfam04052   7 GGGDTALP------IAVVPFQGEGGADLPQDISEVIAADL-----ERSGLFrPIDPAAFPQRPTSDSEVDFADwRALGAD 75

                          90       100
                  ....*....|....*....|....*..
gi 651619984  186 YLLEGSARRAA-GRVRINAQLVDAMSG 211
Cdd:pfam04052  76 ALVTGSVTRGGdGRYKVEFRLYDVVKG 102
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 372-469 3.87e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 3.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 372 ADTWAALSDITVLAGRVEEGLDHIRKAFRLNPfPASWYYLTLGQAQYAAGEYEAAVETLRQ------DETYrtsSRRFLA 445
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDP-DNPEAFALLGEILLQLGDLDEAIVLLHEaleldpDEPE---ARLNLG 79

                         90       100
                 ....*....|....*....|....
gi 651619984 446 ASLAQLGRLDEARAEVELFLVGNP 469
Cdd:COG4783   80 LALLKAGDYDEALALLEKALKLDP 103
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 279-431 6.64e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 6.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  279 EAHLMLRRAVSLDPEYAEAYRWLAINHWmgwvhsggpTEANRSIALELARKAVALDPNDAGCRWVLAYLLAYERSFAEAD 358
Cdd:TIGR02917 483 KAREAFEKALSIEPDFFPAAANLARIDI---------QEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAV 553

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 651619984  359 AEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASwYYLTLGQAQYAAGEYEAAVETLR 431
Cdd:TIGR02917 554 AWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPE-AWLMLGRAQLAAGDLNKAVSSFK 625
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
385-469 8.52e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.61  E-value: 8.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 385 AGRVEEGLDHIRKAFRLNPFPASWYYLtLGQAQYAAGEYEAAVETLR--QDETYRTSSRRFLAASLAQLGRLDEARAEVE 462
Cdd:COG3063    5 LGDLEEAEEYYEKALELDPDNADALNN-LGLLLLEQGRYDEAIALEKalKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                 ....*..
gi 651619984 463 LFLVGNP 469
Cdd:COG3063   84 RALELDP 90
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 413-462 1.74e-03

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 37.23  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 651619984  413 LGQAQYAAGEYEAAVETLRQDETYRTSSR-RFLAA-SLAQLGRLDEARAEVE 462
Cdd:pfam12895  29 LAQCLFLNGQYKRAYELLRKAKLNGSSLGcRYLFAqCLLKLKKYDEALDALG 80
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 323-432 2.08e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 40.74  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLN 402
Cdd:TIGR00990 350 ALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLD 429

                          90       100       110
                  ....*....|....*....|....*....|...
gi 651619984  403 P---FPaswyYLTLGQAQYAAGEYEAAVETLRQ 432
Cdd:TIGR00990 430 PdfiFS----HIQLGVTQYKEGSIASSMATFRR 458
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 328-459 3.67e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  328 RKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPfPAS 407
Cdd:TIGR02917 489 EKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNP-QEI 567

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 651619984  408 WYYLTLGQAQYAAGEYEAAVETLRQ-DETYRTSSRRFLAASLAQL--GRLDEARA 459
Cdd:TIGR02917 568 EPALALAQYYLGKGQLKKALAILNEaADAAPDSPEAWLMLGRAQLaaGDLNKAVS 622
PRK07239 PRK07239
bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated
 2-100 4.62e-03

bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated


Pssm-ID: 235981 [Multi-domain]  Cd Length: 381  Bit Score: 39.19  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984   2 RGSRFAFGPFVLDSGAGTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMdAAWPGTAVEEGNLTVQIALLRKLLGp 81
Cdd:PRK07239 280 RARTLRAAGHVLEIRGHAVVVDGEVKPLSPAPMALLRALAARPGRVVSREDLL-AALPGGGTDEHAVETAVARLRTALG- 357

                         90
                 ....*....|....*....
gi 651619984  82 aadGGQWISTIPRVGYRFA 100
Cdd:PRK07239 358 ---DPKLVQTVVKRGYRLA 373
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 276-427 5.21e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  276 MAQEAHLMLRRAVSLDPEYAEAYRWLAINHWMgwvhSGGPTEanrsiALELARKAVALDPN--DAGCRWVLAYLLAYErs 353
Cdd:TIGR02917 378 DFEKAAEYLAKATELDPENAAARTQLGISKLS----QGDPSE-----AIADLETAAQLDPElgRADLLLILSYLRSGQ-- 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  354 FAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNP--FPASWYYLTL----GQAQYAAGEYEAAV 427
Cdd:TIGR02917 447 FDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPdfFPAAANLARIdiqeGNPDDAIQRFEKVL 526
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 252-430 5.93e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  252 NRPKNLQAYDLCVRARKVMDDSpqmaQEAHLMLRRAVSLDPEYAEAYRWLAINHWmgwvhsggpTEANRSIALELARKAV 331
Cdd:TIGR02917 596 AAPDSPEAWLMLGRAQLAAGDL----NKAVSSFKKLLALQPDSALALLLLADAYA---------VMKNYAKAITSLKRAL 662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  332 ALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNEADTWAALSDITVLAGRVEEGLDHIRKAFRLNPFPASWYYl 411
Cdd:TIGR02917 663 ELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIK- 741

                         170
                  ....*....|....*....
gi 651619984  412 tLGQAQYAAGEYEAAVETL 430
Cdd:TIGR02917 742 -LHRALLASGNTAEAVKTL 759
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 346-432 6.11e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.51  E-value: 6.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984 346 YLLAYERSFAEADAEFAKAIELDPNE---ADTWAALSDITVLAGRVEEGLDHIRKAFRLNP--FPASWYYLTLGQAQYAA 420
Cdd:COG1729    1 KALLKAGDYDEAIAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPdsPKAPDALLKLGLSYLEL 80

                         90
                 ....*....|..
gi 651619984 421 GEYEAAVETLRQ 432
Cdd:COG1729   81 GDYDKARATLEE 92
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 323-401 7.04e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 38.74  E-value: 7.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 651619984 323 ALELARKAVALDPNDAGCRWVLAYLLAYERSFAEADAEFAKAIELDPNeADTWAALSDITVLAGRVEEGLDHIRKAFRL 401
Cdd:COG3071  243 QLKRAEKWLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPS-AEAYAELARLLEQLGDPEEAAEHYRKALAL 320
PRK11906 PRK11906
HilA family transcriptional regulator YgeH;
18-158 8.75e-03

HilA family transcriptional regulator YgeH;


Pssm-ID: 183373 [Multi-domain]  Cd Length: 458  Bit Score: 38.50  E-value: 8.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 651619984  18 GTLLRNDDPVAVGHRGLKLLAALVGRPGEILGKAELMDAAWPGTAVEEGNLTVQIALLRKLLGPAAdGGQWISTIPRVGY 97
Cdd:PRK11906  21 GILTQGNEQVYIPQKELGVLIVLLESAGHVVLKDMIIESVWKNIIVSDESLTRCIYSLRCIFEKIG-YDRCIETIYRKGY 99

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 651619984  98 RFAGAVERlggARREPLPLPDKpSIAVLPFVNVSNDSEQESfadgLTEDLITDLS--RVSGLF 158
Cdd:PRK11906 100 RFSGQVFK---TKINEDNTSDY-SIAIFPFTTSLNTLDPLI----LNQELVQIISnkKIDGLY 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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