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Conserved domains on  [gi|652334571|ref|WP_026731787|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [unclassified Fischerella]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
7-101 2.01e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.02  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   7 DIFKVLANETRLQILHWLKEPEVnfpcqdvdprtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRN 86
Cdd:COG0640   12 ELFKALADPTRLRILRLLAEGEL--------------CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                         90
                 ....*....|....*
gi 652334571  87 EEAFSQFAAHVATDL 101
Cdd:COG0640   78 DEALAELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
7-101 2.01e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.02  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   7 DIFKVLANETRLQILHWLKEPEVnfpcqdvdprtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRN 86
Cdd:COG0640   12 ELFKALADPTRLRILRLLAEGEL--------------CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                         90
                 ....*....|....*
gi 652334571  87 EEAFSQFAAHVATDL 101
Cdd:COG0640   78 DEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 7-92 1.00e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 73.26  E-value: 1.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   7 DIFKVLANETRLQILHWLKEPEVnfpcqdvdprtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRN 86
Cdd:NF033788   3 ELFKALADPTRLRILELLAEGEL--------------CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68


                 ....*.
gi 652334571  87 EEAFSQ 92
Cdd:NF033788  69 DEHVAE 74
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-87 3.67e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 64.24  E-value: 3.67e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 652334571   9 FKVLANETRLQILHWLKEPEVnfpcqdvdprtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRNE 87
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPL--------------TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
44-93 1.09e-11

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 54.91  E-value: 1.09e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 652334571    44 CVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRNEEAFSQF 93
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-79 7.26e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 50.23  E-value: 7.26e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 652334571    7 DIFKVLANETRLQILHWLKEPEvnfpcqdvdprtvGVCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQ 79
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDE-------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 6-84 2.59e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 45.19  E-value: 2.59e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 652334571   6 IDIFKVLANETRLQILHWLKEpevnfpcqdvdprTVGVCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYR 84
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLRE-------------SGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYR 72
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
7-101 2.01e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.02  E-value: 2.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   7 DIFKVLANETRLQILHWLKEPEVnfpcqdvdprtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRN 86
Cdd:COG0640   12 ELFKALADPTRLRILRLLAEGEL--------------CVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLA 77

                         90
                 ....*....|....*
gi 652334571  87 EEAFSQFAAHVATDL 101
Cdd:COG0640   78 DEALAELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 7-92 1.00e-18

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 73.26  E-value: 1.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   7 DIFKVLANETRLQILHWLKEPEVnfpcqdvdprtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRN 86
Cdd:NF033788   3 ELFKALADPTRLRILELLAEGEL--------------CVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLA 68


                 ....*.
gi 652334571  87 EEAFSQ 92
Cdd:NF033788  69 DEHVAE 74
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-87 3.67e-15

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 64.24  E-value: 3.67e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 652334571   9 FKVLANETRLQILHWLKEPEVnfpcqdvdprtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRNE 87
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPL--------------TVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTD 65
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
44-93 1.09e-11

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 54.91  E-value: 1.09e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 652334571    44 CVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRNEEAFSQF 93
Cdd:smart00418  12 CVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADL 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
4-77 1.40e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 55.74  E-value: 1.40e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 652334571   4 KDIDIFKVLANETRLQILHWLKEpevnfpcqdvDPRTVgvcvSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQ 77
Cdd:COG4189    8 ESLEVLKALASETRLRILRLLAE----------EPLNV----NELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
6-97 8.15e-11

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 54.88  E-value: 8.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   6 IDIFKVLANETRLQILHWLKE-PevnfpcqdvdprtvGVCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYR 84
Cdd:COG3398   12 ITRKNVLDNDTRRRIYEYIREnP--------------GIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRYF 77

                         90
                 ....*....|...
gi 652334571  85 RNEEAFSQFAAHV 97
Cdd:COG3398   78 PNSGTYSEEEKKI 90
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
1-89 5.87e-10

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 52.57  E-value: 5.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   1 MDTKDIDIFKVLANETRLQIL-HWLKEPEVNFpcqdvdprtvgvcvSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQ 79
Cdd:COG3398   83 YSEEEKKILAYLRRETPRRILlYLLENPGATN--------------KELAEELGISRSTVSWHLKRLEEDGLVERERDGR 148

                         90
                 ....*....|
gi 652334571  80 STYYRRNEEA 89
Cdd:COG3398  149 NVRYYLNPPE 158
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-79 7.26e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 50.23  E-value: 7.26e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 652334571    7 DIFKVLANETRLQILHWLKEPEvnfpcqdvdprtvGVCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQ 79
Cdd:pfam12840   2 DVAEALADPTRLRILRALVGDE-------------PLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
7-88 8.20e-10

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 51.57  E-value: 8.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 652334571   7 DIFKVLANETRLQILHWLKEpevnfpcqdvDPRTVgvcvSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQS-----T 81
Cdd:COG1777    9 RLLDALGNPTRRRILALLSE----------EPAYV----SELARELGVSRQAVYKHLRKLEEAGLVESYREGREdgrarK 74


                 ....*..
gi 652334571  82 YYRRNEE 88
Cdd:COG1777   75 YYRLSAF 81
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 14-72 1.36e-07

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 43.97  E-value: 1.36e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 652334571   14 NETRLQILHWLKEpevnfpcqdvDPRtvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLI 72
Cdd:pfam01022   1 DPTRLKILKLLAE----------GEL----CVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 6-84 2.59e-07

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 45.19  E-value: 2.59e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 652334571   6 IDIFKVLANETRLQILHWLKEpevnfpcqdvdprTVGVCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYR 84
Cdd:PRK10141   7 LQLFKILSDETRLGIVLLLRE-------------SGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYR 72
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 46-88 8.23e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.59  E-value: 8.23e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 652334571  46 SSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYRRNEE 88
Cdd:COG2512   34 SEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPED 76
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
15-72 3.23e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 32.79  E-value: 3.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 652334571   15 ETRLQILHWLKEpevnfpcqdvDPRTvgvCVSSIQKKTGLAQSTVSHYLSMLEATGLI 72
Cdd:pfam13412   1 ETDRKILNLLQE----------NPRI---SQRELAERLGLSPSTVNRRLKRLEEEGVI 45
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
42-84 4.32e-03

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 34.80  E-value: 4.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 652334571  42 GVCVSSIQKKTGLAQSTVSHYLSMLEATGLIVssRQGQSTYYR 84
Cdd:COG1414   24 GLSLSELARRLGLPKSTVHRLLATLEEEGYVE--RDPEGGRYR 64
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
39-84 4.94e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 33.30  E-value: 4.94e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 652334571  39 RTVGVCVSSIQKKTGLAQSTVSHYLSMLEATGLIVSSRQGQSTYYR 84
Cdd:COG3432   18 KNEGAKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKEDDGGRRIYR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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