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Conserved domains on  [gi|652348933|ref|WP_026745212|]
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HMA2 domain-containing protein [Leptotrichia hofstadii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HMA_2 super family cl45374
Heavy metal associated domain 2; This family of proteins is functionally uncharacterized. This ...
 14-84 1.21e-06

Heavy metal associated domain 2; This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 180 and 190 amino acids in length. These proteins are distantly related to the HMA domain pfam00403 particularly in the N-terminal half of the family. This family lacks the conserved pair of cysteines found in the HMA domain but does have an N-terminal conserved histidine that may fulfil a similar role.


The actual alignment was detected with superfamily member pfam19991:

Pssm-ID: 437823  Cd Length: 154  Bit Score: 44.49  E-value: 1.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 652348933   14 NQIKVVHSIPGRLRLSVPNLsKIPEELKKYdyrVTELILSKKGIKSIEYSYVTNKILIYYDVKLIsEKQIL 84
Cdd:pfam19991   6 GILEVKHAIPGRIRLYIPVL-KNNEELAKE---LVEQLSKIKGIKSVEINTITGSILIEYDEEKI-EPQLL 71
 
Name Accession Description Interval E-value
HMA_2 pfam19991
Heavy metal associated domain 2; This family of proteins is functionally uncharacterized. This ...
 14-84 1.21e-06

Heavy metal associated domain 2; This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 180 and 190 amino acids in length. These proteins are distantly related to the HMA domain pfam00403 particularly in the N-terminal half of the family. This family lacks the conserved pair of cysteines found in the HMA domain but does have an N-terminal conserved histidine that may fulfil a similar role.


Pssm-ID: 437823  Cd Length: 154  Bit Score: 44.49  E-value: 1.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 652348933   14 NQIKVVHSIPGRLRLSVPNLsKIPEELKKYdyrVTELILSKKGIKSIEYSYVTNKILIYYDVKLIsEKQIL 84
Cdd:pfam19991   6 GILEVKHAIPGRIRLYIPVL-KNNEELAKE---LVEQLSKIKGIKSVEINTITGSILIEYDEEKI-EPQLL 71
 
Name Accession Description Interval E-value
HMA_2 pfam19991
Heavy metal associated domain 2; This family of proteins is functionally uncharacterized. This ...
 14-84 1.21e-06

Heavy metal associated domain 2; This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 180 and 190 amino acids in length. These proteins are distantly related to the HMA domain pfam00403 particularly in the N-terminal half of the family. This family lacks the conserved pair of cysteines found in the HMA domain but does have an N-terminal conserved histidine that may fulfil a similar role.


Pssm-ID: 437823  Cd Length: 154  Bit Score: 44.49  E-value: 1.21e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 652348933   14 NQIKVVHSIPGRLRLSVPNLsKIPEELKKYdyrVTELILSKKGIKSIEYSYVTNKILIYYDVKLIsEKQIL 84
Cdd:pfam19991   6 GILEVKHAIPGRIRLYIPVL-KNNEELAKE---LVEQLSKIKGIKSVEINTITGSILIEYDEEKI-EPQLL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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