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Conserved domains on  [gi|654154813|ref|WP_027726611|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Vibrio]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 3.60e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 141.45  E-value: 3.60e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813   1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLASHSKHAql 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE-- 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 654154813  81 gFEEHVRFVDQVVECHNITGSNEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVM 139
Cdd:COG1522   81 -FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 3.60e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 141.45  E-value: 3.60e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813   1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLASHSKHAql 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE-- 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 654154813  81 gFEEHVRFVDQVVECHNITGSNEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVM 139
Cdd:COG1522   81 -FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-108 4.77e-33

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 112.22  E-value: 4.77e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813     1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLASHSKHAQl 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEE- 79

                           90       100
                   ....*....|....*....|....*...
gi 654154813    81 gFEEHVRFVDQVVECHNITGSNEYLLRV 108
Cdd:smart00344  80 -FLEKLEKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-144 1.09e-32

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 113.32  E-value: 1.09e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813   1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLASHSKHAQL 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 654154813  81 GFEEHVRFVDQVVECHNITGSNEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVMDTPKD 144
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQ 155
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 1.05e-15

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 66.30  E-value: 1.05e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 654154813    3 RFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVI 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-52 1.66e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 1.66e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 654154813   2 DRFDERILQALKsDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRA 52
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 3.60e-44

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 141.45  E-value: 3.60e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813   1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLASHSKHAql 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLDE-- 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 654154813  81 gFEEHVRFVDQVVECHNITGSNEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVM 139
Cdd:COG1522   81 -FAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-108 4.77e-33

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 112.22  E-value: 4.77e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813     1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLASHSKHAQl 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEE- 79

                           90       100
                   ....*....|....*....|....*...
gi 654154813    81 gFEEHVRFVDQVVECHNITGSNEYLLRV 108
Cdd:smart00344  80 -FLEKLEKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-144 1.09e-32

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 113.32  E-value: 1.09e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813   1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLASHSKHAQL 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 654154813  81 GFEEHVRFVDQVVECHNITGSNEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVMDTPKD 144
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQ 155
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 1.05e-15

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 66.30  E-value: 1.05e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 654154813    3 RFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVI 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.29e-14

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 63.54  E-value: 1.29e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 654154813    2 DRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-141 7.11e-14

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 62.16  E-value: 7.11e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654154813   67 VSIGLASHSKHAQlgFEEHVRFVDQVVECHNITGSNEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVMDT 141
Cdd:pfam01037   1 VEVKLEPGHALEE--FAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-142 5.99e-12

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 59.34  E-value: 5.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813   1 MDRFDERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRAVLDNQQMGVGFVAYVSIGLAS----HSK 76
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSakdyPSA 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654154813  77 HAQLgfeehvRFVDQVVECHNITGSNEYLLRVETQDLAAYKAFHADVLGECEHVKAITTMVVMDTP 142
Cdd:PRK11179  87 LAKL------ESLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQSTETLISLQNP 146
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-52 1.66e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 46.14  E-value: 1.66e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 654154813   2 DRFDERILQALKsDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYRA 52
Cdd:cd00090    6 DPTRLRILRLLL-EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 5-51 3.22e-06

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 42.59  E-value: 3.22e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 654154813   5 DERILQALKS-DGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYR 51
Cdd:COG2512   17 ERRVLELLREnGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKER 64
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 6-48 2.68e-05

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 42.43  E-value: 2.68e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 654154813   6 ERILQALKSDGRISNVELSERVGLSPsATLRR-VQDLERKGVIK 48
Cdd:COG1349    8 QKILELLRERGRVSVEELAERLGVSE-ETIRRdLAELEEQGLLR 50
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
7-51 5.78e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 40.63  E-value: 5.78e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 654154813   7 RILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYR 51
Cdd:COG3398  101 RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERER 145
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-47 7.83e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.68  E-value: 7.83e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 654154813   6 ERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVI 47
Cdd:COG2345   16 RRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLV 57
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
1-48 5.35e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 38.85  E-value: 5.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 654154813   1 MDRFDERILQALKSDG--RISNVELSERVGLSPSATLRRVQDLERKGVIK 48
Cdd:COG3888    1 MMSLREKILRILKNYGgeGIPQSELVRLLGASKSRVSEILSELEKEGLIA 50
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
7-51 1.13e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.65  E-value: 1.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 654154813     7 RILQALkSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYR 51
Cdd:smart00418   1 KILKLL-AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRR 44
PRK05472 PRK05472
redox-sensing transcriptional repressor Rex; Provisional
 7-83 1.60e-03

redox-sensing transcriptional repressor Rex; Provisional


Pssm-ID: 235486 [Multi-domain]  Cd Length: 213  Bit Score: 37.02  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654154813   7 RILQALKSDG--RISNVELSERVGLSPsATLRRvqDLE------RKGVikGY---------RAVLD-NQQMGVGFVAYVS 68
Cdd:PRK05472  20 RYLKELKEEGveRVSSKELAEALGVDS-AQIRK--DLSyfgefgKRGV--GYnveellefiEKILGlDRTWNVALVGAGN 94

                         90
                 ....*....|....*..
gi 654154813  69 IG--LASHSKHAQLGFE 83
Cdd:PRK05472  95 LGraLLNYNGFEKRGFK 111
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-45 1.87e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 36.49  E-value: 1.87e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 654154813   7 RILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKG 45
Cdd:COG1846   42 RVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKG 80
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
7-51 1.90e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.78  E-value: 1.90e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 654154813   7 RILQALkSDGRISNVELSERVGLSPSATLRRVQDLERKGVIKGYR 51
Cdd:COG1777   21 RILALL-SEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYR 64
BirA COG1654
Biotin operon repressor [Transcription];
6-51 2.52e-03

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 36.89  E-value: 2.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 654154813   6 ERILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVI------KGYR 51
Cdd:COG1654    7 LKLLRLLADGEFHSGEELAEELGVSRAAVWKHIKALRELGYEiesvpgKGYR 58
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
7-48 3.27e-03

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 36.35  E-value: 3.27e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 654154813   7 RILQALKSDGRISNVELSERVGLSPSATLRRVQDLERKGVIK 48
Cdd:PRK04172  10 KVLKALKELKEATLEELAEKLGLPPEAVMRAAEWLEEKGLVK 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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