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Conserved domains on  [gi|654542451|ref|WP_028010270|]
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LuxR family transcriptional regulator [Sinorhizobium meliloti]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10507064)

helix-turn-helix (HTH) transcriptional regulator containing an N-terminal an autoinducer binding domain and a LuxR family HTH DNA-binding domain; may act as an activator or repressor in response to an inducer

Gene Ontology:  GO:0006355|GO:0003677|GO:0003700
PubMed:  15808743|19076237|10473770|8831795

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 25-171 6.23e-24

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 427319  Cd Length: 148  Bit Score: 93.58  E-value: 6.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451   25 SEDDVRRALGRVSEGFGFRGFMvLAIPESGSHSLTAQALMTTWPMDFLRRYDSARLIDGSPVIQRLRRSTIPFTYDAHLL 104
Cdd:pfam03472   1 SEEELFDALARLAAALGFDHFA-YGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLF 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654542451  105 ARGRvdGKGEAAICVFEQANMPRGVYLPVHDAAGHRAAIAFGGDRSAVSDDE----MQALNLWAGLLYSRL 171
Cdd:pfam03472  80 AEAR--GAERRFLDEARDFGLRDGYTVPVHGPGGRLGALSFAGPGEDLDPAEaieaAARLQLLAIYAHLRL 148
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 185-241 6.85e-17

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


:

Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 72.18  E-value: 6.85e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIR 241
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
 
Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 25-171 6.23e-24

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 427319  Cd Length: 148  Bit Score: 93.58  E-value: 6.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451   25 SEDDVRRALGRVSEGFGFRGFMvLAIPESGSHSLTAQALMTTWPMDFLRRYDSARLIDGSPVIQRLRRSTIPFTYDAHLL 104
Cdd:pfam03472   1 SEEELFDALARLAAALGFDHFA-YGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLF 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654542451  105 ARGRvdGKGEAAICVFEQANMPRGVYLPVHDAAGHRAAIAFGGDRSAVSDDE----MQALNLWAGLLYSRL 171
Cdd:pfam03472  80 AEAR--GAERRFLDEARDFGLRDGYTVPVHGPGGRLGALSFAGPGEDLDPAEaieaAARLQLLAIYAHLRL 148
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 185-241 6.85e-17

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 72.18  E-value: 6.85e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIR 241
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 182-239 3.22e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 70.63  E-value: 3.22e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 654542451   182 PGSLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKA 239
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 185-246 4.59e-16

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 72.23  E-value: 4.59e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLIN 246
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
62-245 1.42e-14

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 69.78  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451  62 ALMTTWPMDFLRRYDSARLIDGSPVIQRLRRSTIPFTYDAHLLARGRVDGKGEAAICVFEQANMPRGVYLPVHDAAGHRA 141
Cdd:COG2771    5 ALALLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLAL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451 142 AIAFGGDRSAVSDDEMQALNLWAGLLYSRLSEVRTRDRRGPGSLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLN 221
Cdd:COG2771   85 LLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLK 164

                        170       180
                 ....*....|....*....|....
gi 654542451 222 RATRKLDSVNRVQTVAKAIRAGLI 245
Cdd:COG2771  165 RIYRKLGVSSRAELVALALRLGLI 188
GerE pfam00196
Bacterial regulatory proteins, luxR family;
184-239 4.76e-13

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 61.83  E-value: 4.76e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 654542451  184 SLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKA 239
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
PRK10188 PRK10188
transcriptional regulator SdiA;
185-245 6.68e-10

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 57.49  E-value: 6.68e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLI 245
Cdd:PRK10188 180 FSKREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNKTQIACYAAATGLI 240
PRK13870 PRK13870
transcriptional regulator TraR; Provisional
 13-245 5.86e-08

transcriptional regulator TraR; Provisional


Pssm-ID: 172390 [Multi-domain]  Cd Length: 234  Bit Score: 51.92  E-value: 5.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451  13 LPDGHAISGSidsEDDVRRALGRVSEGFGFRGFMVLAIPEsgsHSLTAqalMTTWPMDFLRRYDSARLIDGSPVIQRLRR 92
Cdd:PRK13870   8 LTDLAAIEGD---ECILKTGLADIADHFGFTGYAYLHIQH---RHITA---VTNYHREWQSVYFDKKFDALDPVVKRARS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451  93 STIPFTYDAHLlARGRVDGKGEAAICVFEQANMPRGVYLPVHDAAGHRAAIAFGGDRSAVS-DDEMQALNLWA--GLLYS 169
Cdd:PRK13870  79 RKHIFTWSGEQ-ERPRLSKDERAFYAHAADFGIRSGITIPIKTANGSMSMFTLASEKPVIDlDREIDAVAAAAtiGQIHA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654542451 170 RLSEVRTRDRRGPGS-LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLI 245
Cdd:PRK13870 158 RISFLRTTPTAEDAAwLDPKEATYLRWIAVGKTMEEIADVEGVKYNSVRVKLREAMKRFDVRSKAHLTALAIRRKLI 234
 
Name Accession Description Interval E-value
Autoind_bind pfam03472
Autoinducer binding domain; This domain is found a a large family of transcriptional ...
 25-171 6.23e-24

Autoinducer binding domain; This domain is found a a large family of transcriptional regulators. This domain specifically binds to autoinducer molecules (N-Acyl homoserine lactones, chlorolactone and rosmarinic acid) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 427319  Cd Length: 148  Bit Score: 93.58  E-value: 6.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451   25 SEDDVRRALGRVSEGFGFRGFMvLAIPESGSHSLTAQALMTTWPMDFLRRYDSARLIDGSPVIQRLRRSTIPFTYDAHLL 104
Cdd:pfam03472   1 SEEELFDALARLAAALGFDHFA-YGARAPLGLSAPDVLVLSNYPAEWLDRYDEANYFAIDPVVRHARRSSSPFSWSDVLF 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654542451  105 ARGRvdGKGEAAICVFEQANMPRGVYLPVHDAAGHRAAIAFGGDRSAVSDDE----MQALNLWAGLLYSRL 171
Cdd:pfam03472  80 AEAR--GAERRFLDEARDFGLRDGYTVPVHGPGGRLGALSFAGPGEDLDPAEaieaAARLQLLAIYAHLRL 148
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 185-241 6.85e-17

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 72.18  E-value: 6.85e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIR 241
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 182-239 3.22e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 70.63  E-value: 3.22e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 654542451   182 PGSLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKA 239
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 185-246 4.59e-16

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 72.23  E-value: 4.59e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLIN 246
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLLD 131
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 178-245 7.32e-15

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 67.29  E-value: 7.32e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654542451 178 DRRGPGSLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLI 245
Cdd:COG5905    6 STSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
62-245 1.42e-14

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 69.78  E-value: 1.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451  62 ALMTTWPMDFLRRYDSARLIDGSPVIQRLRRSTIPFTYDAHLLARGRVDGKGEAAICVFEQANMPRGVYLPVHDAAGHRA 141
Cdd:COG2771    5 ALALLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLLAL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451 142 AIAFGGDRSAVSDDEMQALNLWAGLLYSRLSEVRTRDRRGPGSLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLN 221
Cdd:COG2771   85 LLLLALLALLAALLARLAALLLALALAALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLK 164

                        170       180
                 ....*....|....*....|....
gi 654542451 222 RATRKLDSVNRVQTVAKAIRAGLI 245
Cdd:COG2771  165 RIYRKLGVSSRAELVALALRLGLI 188
GerE pfam00196
Bacterial regulatory proteins, luxR family;
184-239 4.76e-13

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 61.83  E-value: 4.76e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 654542451  184 SLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKA 239
Cdd:pfam00196   2 SLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
PRK10188 PRK10188
transcriptional regulator SdiA;
185-245 6.68e-10

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 57.49  E-value: 6.68e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLI 245
Cdd:PRK10188 180 FSKREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNKTQIACYAAATGLI 240
PRK13870 PRK13870
transcriptional regulator TraR; Provisional
 13-245 5.86e-08

transcriptional regulator TraR; Provisional


Pssm-ID: 172390 [Multi-domain]  Cd Length: 234  Bit Score: 51.92  E-value: 5.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451  13 LPDGHAISGSidsEDDVRRALGRVSEGFGFRGFMVLAIPEsgsHSLTAqalMTTWPMDFLRRYDSARLIDGSPVIQRLRR 92
Cdd:PRK13870   8 LTDLAAIEGD---ECILKTGLADIADHFGFTGYAYLHIQH---RHITA---VTNYHREWQSVYFDKKFDALDPVVKRARS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451  93 STIPFTYDAHLlARGRVDGKGEAAICVFEQANMPRGVYLPVHDAAGHRAAIAFGGDRSAVS-DDEMQALNLWA--GLLYS 169
Cdd:PRK13870  79 RKHIFTWSGEQ-ERPRLSKDERAFYAHAADFGIRSGITIPIKTANGSMSMFTLASEKPVIDlDREIDAVAAAAtiGQIHA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654542451 170 RLSEVRTRDRRGPGS-LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLI 245
Cdd:PRK13870 158 RISFLRTTPTAEDAAwLDPKEATYLRWIAVGKTMEEIADVEGVKYNSVRVKLREAMKRFDVRSKAHLTALAIRRKLI 234
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
155-245 2.09e-05

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 43.92  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654542451 155 DEMQALNLWAGLLYSRLSEVRTRDRRGPGSLSRREIEcLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQ 234
Cdd:COG2909   94 ALLERLLALAEAAGRLLLRALALRALGDREEALAALR-RRLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTE 172

                         90
                 ....*....|.
gi 654542451 235 TVAKAIRAGLI 245
Cdd:COG2909  173 AVARARELGLL 183
PRK10100 PRK10100
transcriptional regulator CsgD;
185-239 5.49e-03

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 37.16  E-value: 5.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 654542451 185 LSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKA 239
Cdd:PRK10100 156 LTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWA 210
PRK09483 PRK09483
response regulator; Provisional
 171-246 9.01e-03

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 36.24  E-value: 9.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654542451 171 LSEVRTRDRRGPGSLSRREIECLRWAAAGKTTVEMARIMALSEYTVNHYLNRATRKLDSVNRVQTVAKAIRAGLIN 246
Cdd:PRK09483 135 LSQIEPATENPFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLLN 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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