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Conserved domains on  [gi|654544566|ref|WP_028012274|]
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MULTISPECIES: anti-sigma factor domain-containing protein [Enterobacter]

Protein Classification

anti-sigma factor( domain architecture ID 11475021)

anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor which has a putative zinc finger domain and may bind zinc; its anti-sigma factor domain is similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; zf-HC2 domain-containing anti-sigma factor; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor which has a putative zinc finger domain and may bind zinc; its anti-sigma factor domain is similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor similar to mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis; anti-sigma factor such as mycobacterial anti-sigma-K factor RskA, an anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK; ECF sigma factors are held in an inactive form by an anti-sigma factor until r

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RskA COG5343
Anti-sigma-K factor RskA [Signal transduction mechanisms];
1-215 4.76e-63

Anti-sigma-K factor RskA [Signal transduction mechanisms];


:

Pssm-ID: 444127 [Multi-domain]  Cd Length: 239  Bit Score: 196.01  E-value: 4.76e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566   1 MNDAEKRDDMLAAEYALGTLRGGARLQFQKRVLREPALAARVAYWQDMFSTLDSHLVPVPPPETVWKRIALDL------- 73
Cdd:COG5343    1 MNTPEYDLDALAGEYVLGTLSGEERREFERRLASDPELAAEVAEWEERLAPLADAVEPVAPPPSLWARIEARLdaaraaa 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  74 -PPKKPLRQSRPYLGWMVAASLAALTVVAWYA--------TRAPELAPLM--VLNDAQQHGQWVVSADASRQHLSIAPLR 142
Cdd:COG5343   81 aAPAARLWRRLRFWRGLAAAAAAAALLLAVVLvwllqpqlNPAPQQVPQLvaVLAADDGGPAAVVVVDPSSGELVLTPLG 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654544566 143 PTAVAAQHSLQLWLIPGGQAPVSMGLLHNDIPTRVTLRNATLP---ADATIAISLEPEGGSPTGLPTGPVLYSGKL 215
Cdd:COG5343  161 LPAPPAGKSYQLWAIPDDGAPVSLGLLPPGGSTTLPLPAALAPllaAGAALAVTLEPAGGSPTGLPTGPVLAVGRL 236
 
Name Accession Description Interval E-value
RskA COG5343
Anti-sigma-K factor RskA [Signal transduction mechanisms];
1-215 4.76e-63

Anti-sigma-K factor RskA [Signal transduction mechanisms];


Pssm-ID: 444127 [Multi-domain]  Cd Length: 239  Bit Score: 196.01  E-value: 4.76e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566   1 MNDAEKRDDMLAAEYALGTLRGGARLQFQKRVLREPALAARVAYWQDMFSTLDSHLVPVPPPETVWKRIALDL------- 73
Cdd:COG5343    1 MNTPEYDLDALAGEYVLGTLSGEERREFERRLASDPELAAEVAEWEERLAPLADAVEPVAPPPSLWARIEARLdaaraaa 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  74 -PPKKPLRQSRPYLGWMVAASLAALTVVAWYA--------TRAPELAPLM--VLNDAQQHGQWVVSADASRQHLSIAPLR 142
Cdd:COG5343   81 aAPAARLWRRLRFWRGLAAAAAAAALLLAVVLvwllqpqlNPAPQQVPQLvaVLAADDGGPAAVVVVDPSSGELVLTPLG 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654544566 143 PTAVAAQHSLQLWLIPGGQAPVSMGLLHNDIPTRVTLRNATLP---ADATIAISLEPEGGSPTGLPTGPVLYSGKL 215
Cdd:COG5343  161 LPAPPAGKSYQLWAIPDDGAPVSLGLLPPGGSTTLPLPAALAPllaAGAALAVTLEPAGGSPTGLPTGPVLAVGRL 236
RskA pfam10099
Anti-sigma-K factor rskA; This domain, formerly known as DUF2337, is the anti-sigma-K factor, ...
61-213 6.64e-15

Anti-sigma-K factor rskA; This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83.


Pssm-ID: 431053  Cd Length: 180  Bit Score: 69.78  E-value: 6.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566   61 PPETVWKRIALDL--------------PPKKPLRQSRPYLGWMVAASLAALTVVAWYATRAPELAPL------------- 113
Cdd:pfam10099   1 PPPRLWDRILARLaatpqappaaapppAARARRPRRRRRARLAAAAAAAVLVALGQLVRLQAELAPLqqaaaqapqlvav 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  114 MVLNDAQQHGQWVVSADASRQHLSIAPLRP-TAVAAQHSLQLWLIPGGQAPVSMGLLHNDIPTRVTLRNATLPADA-TIA 191
Cdd:pfam10099  81 LAAPDAGAGGATATVVDSPSGGLAVVPVAGlPALPAGKVYQLWLIPDDGGPVSLGVFDGGGAATLTLPLLPDLGAAaALA 160
                         170       180
                  ....*....|....*....|..
gi 654544566  192 ISLEPEGGSPTglPTGPVLYSG 213
Cdd:pfam10099 161 VTVEPAGGSPQ--PTGPVVAKG 180
PRK13920 PRK13920
putative anti-sigmaE protein; Provisional
15-210 9.61e-12

putative anti-sigmaE protein; Provisional


Pssm-ID: 237558 [Multi-domain]  Cd Length: 206  Bit Score: 61.76  E-value: 9.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  15 YALGTLRGGARLQFQKRVLREPALAARVAYWQDMFSTLDSHLVPVPPPETVWKRIALDLPPKK----PLRQSRPYLGWMV 90
Cdd:PRK13920   4 YALGALSPEERARVEAALEAYPELWAELRALQEALAALAEGLPPVPVPPGLEERVLARLRPRRlpllPLLARAAAALALL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  91 AASLAALTVVAWYATRAPELAPLMVLndaQQHGQWVVSADASRQHLSIAPLRPTAVAAQHS---------LQLWLIPGGQ 161
Cdd:PRK13920  84 LAGYGLAAGLSWTLSLREPATLRHYA---RLPGRVYALVGPEGEPVGRAVWRKDGRALVVLkrpppagrvYQAWGLKKGQ 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 654544566 162 aPVSMGLLHndipTRVTLRNAtLPADATIAISLEPEGGSPTglPTGPVL 210
Cdd:PRK13920 161 -PVSLGTFR----GPLKLTRL-PPGADALAVSLEPPGGSPQ--PTEPLG 201
 
Name Accession Description Interval E-value
RskA COG5343
Anti-sigma-K factor RskA [Signal transduction mechanisms];
1-215 4.76e-63

Anti-sigma-K factor RskA [Signal transduction mechanisms];


Pssm-ID: 444127 [Multi-domain]  Cd Length: 239  Bit Score: 196.01  E-value: 4.76e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566   1 MNDAEKRDDMLAAEYALGTLRGGARLQFQKRVLREPALAARVAYWQDMFSTLDSHLVPVPPPETVWKRIALDL------- 73
Cdd:COG5343    1 MNTPEYDLDALAGEYVLGTLSGEERREFERRLASDPELAAEVAEWEERLAPLADAVEPVAPPPSLWARIEARLdaaraaa 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  74 -PPKKPLRQSRPYLGWMVAASLAALTVVAWYA--------TRAPELAPLM--VLNDAQQHGQWVVSADASRQHLSIAPLR 142
Cdd:COG5343   81 aAPAARLWRRLRFWRGLAAAAAAAALLLAVVLvwllqpqlNPAPQQVPQLvaVLAADDGGPAAVVVVDPSSGELVLTPLG 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654544566 143 PTAVAAQHSLQLWLIPGGQAPVSMGLLHNDIPTRVTLRNATLP---ADATIAISLEPEGGSPTGLPTGPVLYSGKL 215
Cdd:COG5343  161 LPAPPAGKSYQLWAIPDDGAPVSLGLLPPGGSTTLPLPAALAPllaAGAALAVTLEPAGGSPTGLPTGPVLAVGRL 236
RskA pfam10099
Anti-sigma-K factor rskA; This domain, formerly known as DUF2337, is the anti-sigma-K factor, ...
61-213 6.64e-15

Anti-sigma-K factor rskA; This domain, formerly known as DUF2337, is the anti-sigma-K factor, RskA. In Mycobacterium tuberculosis the protein positively regulates expression of the antigenic proteins MPB70 and MPB83.


Pssm-ID: 431053  Cd Length: 180  Bit Score: 69.78  E-value: 6.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566   61 PPETVWKRIALDL--------------PPKKPLRQSRPYLGWMVAASLAALTVVAWYATRAPELAPL------------- 113
Cdd:pfam10099   1 PPPRLWDRILARLaatpqappaaapppAARARRPRRRRRARLAAAAAAAVLVALGQLVRLQAELAPLqqaaaqapqlvav 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  114 MVLNDAQQHGQWVVSADASRQHLSIAPLRP-TAVAAQHSLQLWLIPGGQAPVSMGLLHNDIPTRVTLRNATLPADA-TIA 191
Cdd:pfam10099  81 LAAPDAGAGGATATVVDSPSGGLAVVPVAGlPALPAGKVYQLWLIPDDGGPVSLGVFDGGGAATLTLPLLPDLGAAaALA 160
                         170       180
                  ....*....|....*....|..
gi 654544566  192 ISLEPEGGSPTglPTGPVLYSG 213
Cdd:pfam10099 161 VTVEPAGGSPQ--PTGPVVAKG 180
PRK13920 PRK13920
putative anti-sigmaE protein; Provisional
15-210 9.61e-12

putative anti-sigmaE protein; Provisional


Pssm-ID: 237558 [Multi-domain]  Cd Length: 206  Bit Score: 61.76  E-value: 9.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  15 YALGTLRGGARLQFQKRVLREPALAARVAYWQDMFSTLDSHLVPVPPPETVWKRIALDLPPKK----PLRQSRPYLGWMV 90
Cdd:PRK13920   4 YALGALSPEERARVEAALEAYPELWAELRALQEALAALAEGLPPVPVPPGLEERVLARLRPRRlpllPLLARAAAALALL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544566  91 AASLAALTVVAWYATRAPELAPLMVLndaQQHGQWVVSADASRQHLSIAPLRPTAVAAQHS---------LQLWLIPGGQ 161
Cdd:PRK13920  84 LAGYGLAAGLSWTLSLREPATLRHYA---RLPGRVYALVGPEGEPVGRAVWRKDGRALVVLkrpppagrvYQAWGLKKGQ 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 654544566 162 aPVSMGLLHndipTRVTLRNAtLPADATIAISLEPEGGSPTglPTGPVL 210
Cdd:PRK13920 161 -PVSLGTFR----GPLKLTRL-PPGADALAVSLEPPGGSPQ--PTEPLG 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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