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Conserved domains on  [gi|654544779|ref|WP_028012487|]
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MULTISPECIES: undecaprenyl-diphosphate phosphatase [Enterobacter]

Protein Classification

undecaprenyl-diphosphatase( domain architecture ID 10793621)

undecaprenyl-diphosphatase catalyzes the dephosphorylation of undecaprenyl diphosphate to undecaprenyl phosphate, includes Bacillus subtilis BcrC and Escherichia coli YbjG

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 1-202 5.73e-123

undecaprenyl pyrophosphate phosphatase; Provisional


:

Pssm-ID: 183335  Cd Length: 202  Bit Score: 345.84  E-value: 5.73e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   1 MLENLNYQLFYLINATPASPEWMIDFATFLAKDLISIVPALAAILWLWGPRSQVKAQRQLVIKVAMALGVSVLVSYLLGH 80
Cdd:PRK11837   1 MLENLNLSLFSLINATPDSAPWMISLAIFIAKDLILIVPLLAVVLWLWGPRDQLTAQRQLVIKIAIALAISLLVSWTIGH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  81 AFPHDRPFVDRIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFWHRLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLV 160
Cdd:PRK11837  81 LFPHDRPFVEGIGYNFLHHAADDSFPSDHGTVIFTFALAFLFWHRLWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 654544779 161 GLIGCVSAAILWNLFGEALYRGLSSLYRAIFAIPIRKGWIRD 202
Cdd:PRK11837 161 GMIGCLSAQIIWQLFGEKLYQRLQRLYRFCFALPIRKGWVRD 202
 
Name Accession Description Interval E-value
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 1-202 5.73e-123

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 345.84  E-value: 5.73e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   1 MLENLNYQLFYLINATPASPEWMIDFATFLAKDLISIVPALAAILWLWGPRSQVKAQRQLVIKVAMALGVSVLVSYLLGH 80
Cdd:PRK11837   1 MLENLNLSLFSLINATPDSAPWMISLAIFIAKDLILIVPLLAVVLWLWGPRDQLTAQRQLVIKIAIALAISLLVSWTIGH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  81 AFPHDRPFVDRIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFWHRLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLV 160
Cdd:PRK11837  81 LFPHDRPFVEGIGYNFLHHAADDSFPSDHGTVIFTFALAFLFWHRLWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 654544779 161 GLIGCVSAAILWNLFGEALYRGLSSLYRAIFAIPIRKGWIRD 202
Cdd:PRK11837 161 GMIGCLSAQIIWQLFGEKLYQRLQRLYRFCFALPIRKGWVRD 202
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 23-168 7.49e-54

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 168.59  E-value: 7.49e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  23 MIDFATFLAKDLISIVPALAAILWLWGPRSQvkaqRQLVIKVAMALGVSVLVSYLLGHAFPHDRPFVDRIGYTFLHHAPD 102
Cdd:cd03385    1 LDALAIFIAEYLIYILPLLLVVLWLWGGEKQ----RKVVLFATIAVAVALLINYIIGLLYFHPRPFVVGLGHNLLPHAAD 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654544779 103 DSFPSDHGTVIFTFALAFLFWHRLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGCVSA 168
Cdd:cd03385   77 SSFPSDHTTLFFSIAFSLLLRRRKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLV 142
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 9-173 3.68e-20

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 83.55  E-value: 3.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   9 LFYLINATPASPEWMIDFATFLAKDLISIVPALAAILWLWGPRSQVKAQRQLVIKVAMALGVSVLVSYLLGHAFPHDRPF 88
Cdd:COG0671   23 ALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPF 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  89 VDRIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFWH-RLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGCVS 167
Cdd:COG0671  103 VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLpRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALL 182


                 ....*.
gi 654544779 168 AAILWN 173
Cdd:COG0671  183 LLALLR 188
acidPPc smart00014
Acid phosphatase homologues;
65-168 1.42e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 71.99  E-value: 1.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779    65 AMALGVSVLVSYLLGHAFPHDRPFVDRIG------YTFLHHAPDDSFPSDHGTVIFTFALAFLFWHRLWSGAVL-----M 133
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGdacctpNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLlifllL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 654544779   134 VVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGCVSA 168
Cdd:smart00014  81 LLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 67-163 4.78e-10

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 55.12  E-value: 4.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   67 ALGVSVLVSYLLGHAFPHDRPFVD-----RIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFW-------HRLWSGAVLMV 134
Cdd:pfam01569   5 ALALAGLLSSVLKDYFGRPRPFFLlleggLVPAPSTLPGLGYSFPSGHSATAFALALLLALLlrrlrkiVRVLLALLLLV 84

                          90       100
                  ....*....|....*....|....*....
gi 654544779  135 VAVAIAWSRVYLGVHWPLDMVGGFLVGLI 163
Cdd:pfam01569  85 LALLVGLSRLYLGVHFPSDVLAGALIGIL 113
 
Name Accession Description Interval E-value
PRK11837 PRK11837
undecaprenyl pyrophosphate phosphatase; Provisional
 1-202 5.73e-123

undecaprenyl pyrophosphate phosphatase; Provisional


Pssm-ID: 183335  Cd Length: 202  Bit Score: 345.84  E-value: 5.73e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   1 MLENLNYQLFYLINATPASPEWMIDFATFLAKDLISIVPALAAILWLWGPRSQVKAQRQLVIKVAMALGVSVLVSYLLGH 80
Cdd:PRK11837   1 MLENLNLSLFSLINATPDSAPWMISLAIFIAKDLILIVPLLAVVLWLWGPRDQLTAQRQLVIKIAIALAISLLVSWTIGH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  81 AFPHDRPFVDRIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFWHRLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLV 160
Cdd:PRK11837  81 LFPHDRPFVEGIGYNFLHHAADDSFPSDHGTVIFTFALAFLFWHRLWSGSLLMAIAVAIAWSRVYLGVHWPLDMLGALLV 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 654544779 161 GLIGCVSAAILWNLFGEALYRGLSSLYRAIFAIPIRKGWIRD 202
Cdd:PRK11837 161 GMIGCLSAQIIWQLFGEKLYQRLQRLYRFCFALPIRKGWVRD 202
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 23-168 7.49e-54

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 168.59  E-value: 7.49e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  23 MIDFATFLAKDLISIVPALAAILWLWGPRSQvkaqRQLVIKVAMALGVSVLVSYLLGHAFPHDRPFVDRIGYTFLHHAPD 102
Cdd:cd03385    1 LDALAIFIAEYLIYILPLLLVVLWLWGGEKQ----RKVVLFATIAVAVALLINYIIGLLYFHPRPFVVGLGHNLLPHAAD 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654544779 103 DSFPSDHGTVIFTFALAFLFWHRLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGCVSA 168
Cdd:cd03385   77 SSFPSDHTTLFFSIAFSLLLRRRKWAGWILLILALLVAWSRIYLGVHYPLDMLGAALVAVLSALLV 142
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 9-173 3.68e-20

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 83.55  E-value: 3.68e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   9 LFYLINATPASPEWMIDFATFLAKDLISIVPALAAILWLWGPRSQVKAQRQLVIKVAMALGVSVLVSYLLGHAFPHDRPF 88
Cdd:COG0671   23 ALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPF 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  89 VDRIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFWH-RLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGCVS 167
Cdd:COG0671  103 VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLpRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALL 182


                 ....*.
gi 654544779 168 AAILWN 173
Cdd:COG0671  183 LLALLR 188
acidPPc smart00014
Acid phosphatase homologues;
65-168 1.42e-16

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 71.99  E-value: 1.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779    65 AMALGVSVLVSYLLGHAFPHDRPFVDRIG------YTFLHHAPDDSFPSDHGTVIFTFALAFLFWHRLWSGAVL-----M 133
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGdacctpNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLlifllL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 654544779   134 VVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGCVSA 168
Cdd:smart00014  81 LLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVL 115
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 14-163 3.90e-15

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 69.95  E-value: 3.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  14 NATPASPEWMIDFATFLAKDLISIVPALAAILWLWgprsqvKAQRQLVIKVAMALGVSVLVSYLLGHAFPHDRPFVDRIG 93
Cdd:cd03392   23 LRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLL------KRRRRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLV 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 654544779  94 ytflhHAPDDSFPSDH--GTVIFTFALAFLFWHRLWSG-------AVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVGLI 163
Cdd:cd03392   97 -----PEGGYSFPSGHamGATVLYGFLAYLLARRLPRRrvrilllILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLA 170
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 58-166 2.69e-14

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 66.33  E-value: 2.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  58 RQLVIKVAMALGVSVLVSYLLGHAFPHDRPFV----DRIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFW-----HRLWS 128
Cdd:cd01610    2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFllrcGPDGDPLLLTEGGYSFPSGHAAFAFALALFLALLlprrlLRLLL 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 654544779 129 GAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGCV 166
Cdd:cd01610   82 GLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVAL 119
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 1-164 1.00e-13

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 66.13  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   1 MLENLNYQLFYLINATPASPeWMIDFATFLAKDLISIVPALAAILWLWgprsqVKAQRQLVIKVAMALGVSVLVSYLLGH 80
Cdd:cd03395    1 LLEQIDVWLFLLLNGTLVHP-LLDDLMPFLTGKKLSVPIFLLLALFIL-----FRKGPIGLLILLLVLLAVGFADQLASG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  81 AFphdRPFVDRIGYTFLHHAPDD----------SFPSDHGTVIFTFALAF-LFWHRLWSGAVLMVVAVAIAWSRVYLGVH 149
Cdd:cd03395   75 FL---KPLVARLRPCNALDGVRLvvlgdqggsySFASSHAANSFALALFIwLFFRRGLFSPVLLLWALLVGYSRVYVGVH 151

                        170
                 ....*....|....*
gi 654544779 150 WPLDMVGGFLVGLIG 164
Cdd:cd03395  152 YPGDVIAGALIGIIS 166
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 67-163 4.78e-10

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 55.12  E-value: 4.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779   67 ALGVSVLVSYLLGHAFPHDRPFVD-----RIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFW-------HRLWSGAVLMV 134
Cdd:pfam01569   5 ALALAGLLSSVLKDYFGRPRPFFLlleggLVPAPSTLPGLGYSFPSGHSATAFALALLLALLlrrlrkiVRVLLALLLLV 84

                          90       100
                  ....*....|....*....|....*....
gi 654544779  135 VAVAIAWSRVYLGVHWPLDMVGGFLVGLI 163
Cdd:pfam01569  85 LALLVGLSRLYLGVHFPSDVLAGALIGIL 113
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 64-172 1.97e-09

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 53.10  E-value: 1.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  64 VAMALGVSVLVSYLLGHAFPHDRPFVDRIGYtflhhapdDSFPSDHGTVIFTFALAF---LFWHrlWSGAVLMVVAVAIA 140
Cdd:cd03394    8 LAEAAALTAAVTEGLKFAVGRARPDGSNNGY--------RSFPSGHTASAFAAATFLqyrYGWR--WYGIPAYALASLVG 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 654544779 141 WSRVYLGVHWPLDMVGGflvGLIGCVSAAILW 172
Cdd:cd03394   78 ASRVVANRHWLSDVLAG---AAIGILVGYLVT 106
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 58-166 8.41e-08

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 48.91  E-value: 8.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  58 RQLVIKVAMALGVSVLVSYLLGHAFPHDRPFV-DRIGYTFLHHAPDDSFPSDHGTVIFTFALAFLFWHR---LWSGAVLM 133
Cdd:cd03393   12 KRLGRYLGLALCASGYLNAALKEVFKIPRPFTyDGIQAIYEESAGGYGFPSGHAQTSATFWGSLMLHVRkkwFTLIGVVL 91

                         90       100       110
                 ....*....|....*....|....*....|...
gi 654544779 134 VVAVAIawSRVYLGVHWPLDMVGGFLVGLIGCV 166
Cdd:cd03393   92 VVLISF--SRLYLGVHWPSDVIGGVLIGLLVLV 122
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 86-161 9.73e-07

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 47.43  E-value: 9.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  86 RPFV------DRIGYTFLHHAPDDSFPSDHGTVIFTFA--LAFLFwHRLWSGavLMVVAVAIAWSRVYLGVHWPLDMVGG 157
Cdd:cd03380  120 RPFVairlqwLPICTPEEGTPKHPSYPSGHATFGGAAAlvLAELF-PERAAE--LLARAAEAGNSRVVAGVHWPSDVEAG 196


                 ....
gi 654544779 158 FLVG 161
Cdd:cd03380  197 RILG 200
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 99-161 4.74e-06

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 44.53  E-value: 4.74e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  99 HAPDDSFPSDHGTVIFTFALAFLFW-HRLWSGAVLMVVAVAIAW------SRVYLGVHWPLDMVGGFLVG 161
Cdd:cd03388   74 AALEYGFPSTHAMNATAISFYLLIYlYDRYQYPFVLGLILALFYstlvclSRIYMGMHSVLDVIAGSLIG 143
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 43-162 1.20e-05

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 43.85  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  43 AILWLWGP-----RSQVKAQRQLVIKVAMALGVSVLVSYLLGHAFPHDRPFVDRIGYtFLHHAPDD-SFPSDHGTVIFtF 116
Cdd:cd03391   26 GIPWLAGTisclwISSSPAGQEVLVNLLLGLLLDIITVAILKALVRRRRPAYNSPDM-LDYVAVDKySFPSGHASRAA-F 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 654544779 117 ALAFLFWHRLWSGAVLMVV---AVAIAWSRVYLGVHWPLDMVGGFLVGL 162
Cdd:cd03391  104 VARFLLNHLVLAVPLRVLLvlwATVVGISRVLLGRHHVLDVLAGAFLGY 152
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 93-175 2.38e-05

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 43.08  E-value: 2.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  93 GYTFLH-HAPDDSFPSDHGTVIFTF--ALAFLFWHRLWSGAVLMVVavaIAWSRVYLGVHWPLDMVGGFlvgLIGCVSAA 169
Cdd:cd03389  107 GFDPFHaDYAFTSFPSGHSATAGAAaaALALLFPRYRWAFILLALL---IAFSRVIVGAHYPSDVIAGS---LLGAVTAL 180


                 ....*.
gi 654544779 170 ILWNLF 175
Cdd:cd03389  181 ALYQRF 186
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 102-173 1.45e-04

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 41.17  E-value: 1.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 654544779 102 DDSFPSDHGTVIFT--FALAFLFWHRlwsGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVgliGCVSAAILWN 173
Cdd:cd03397  149 DGSYPSGHTAAGYAwaLILAELVPER---ADEILARGSEYGQSRIVCGVHWPSDVMGGRIM---AAALVAALLA 216
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 29-171 5.23e-04

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 39.20  E-value: 5.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  29 FLAKDLISIVPALAAILWLWGPRSQVKAQRQLV-IKVAMALGVSVLVSYLLGHAFPHDRP-----FVDRIGYTFLHHAPD 102
Cdd:cd03396   36 LGGRLLSIALAVLLLALALLFFRRKRLRRRRRAlLLLILVIGLGLLVVAILKSHWGRPRPwdlteFGGDAPYTPLFSGPS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779 103 D------SFPSDHGTVIFTF-ALAFLFWHRLWSGAVLMVVAV-----AIAWSRVYLGVHWPLDMV-GGFLVGLIGCVSAA 169
Cdd:cd03396  116 NgcgkgcSFPSGHASAGFALlALYFLFRRRRPRLARLVLAAGlalgaLMGLARMARGAHFLSDVLwSLLLVWLIALLLYR 195


                 ..
gi 654544779 170 IL 171
Cdd:cd03396  196 LI 197
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 70-163 1.45e-03

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 37.64  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654544779  70 VSVLVSYLLGHAFPHDRPfvdrigYTFLHHAPDD-SFPSDHGTVIFTFALAFL------------FWHRLWSGAVLMVVA 136
Cdd:cd03382   53 ANEALNYVLKRIIKEPRP------CSGAYFVRSGyGMPSSHSQFMGFFAVYLLlfiylrlgrlnsLVSRFLLSLGLLLLA 126

                         90       100
                 ....*....|....*....|....*..
gi 654544779 137 VAIAWSRVYLGVHWPLDMVGGFLVGLI 163
Cdd:cd03382  127 LLVSYSRVYLGYHTVSQVVVGAIVGIL 153
PAP2_Aur1_like cd03386
PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of ...
 105-165 1.60e-03

PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin.


Pssm-ID: 239481  Cd Length: 186  Bit Score: 37.68  E-value: 1.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654544779 105 FPSDHGTVIFTFALAFLFWHRLWSGAVLMVVAVAIAWSRVYLGVHWPLDMVGGFLVGLIGC 165
Cdd:cd03386  119 FPSLHVAWAVLAALFLWRHRRRLLRWLAVLWPLLIWLSTLYLGNHYFIDLVGGIALALLSF 179
PRK10699 PRK10699
phosphatidylglycerophosphatase B; Provisional
 104-160 1.74e-03

phosphatidylglycerophosphatase B; Provisional


Pssm-ID: 182658  Cd Length: 244  Bit Score: 38.09  E-value: 1.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654544779 104 SFPSDHGTVIFTFAL--AFLFWHRLWSG--AVLMVVAVAIAWSRVYLGVHWPLDMVGGFLV 160
Cdd:PRK10699 158 AFPSGHTMFAASWALlaVGLLWPRRRYKtvALLMLWATGVMGSRLLLGMHWPRDLVVATLI 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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