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Conserved domains on  [gi|654546230|ref|WP_028013936|]
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MULTISPECIES: SLC13 family permease [Enterobacter]

Protein Classification

SLC13 family permease( domain architecture ID 18423072)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Gene Ontology:  GO:0008324
PubMed:  23506872|12915942|24114175

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 1.32e-58

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 200.38  E-value: 1.32e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  61 AALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQS-----SPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSekrskFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFSVTPLGLVILAMGVVYMLLTRfalkgdkqdknkegwkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 216 tfrdlikeyrltgrarrlairpgspmvgqrlddlklreryganvigverWRRFRRVIVNVNGVSEfrardvllidmstad 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKE--------------- 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 296 vdlrefcseqllepmvlrgeyfsdqaldvgmaevslipeseLLGKTVREMGFRTRyglnvvglkrdgvamegavvdepil 375
Cdd:COG0471  159 -----------------------------------------VIREELAELGPLSR------------------------- 172

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 376 lgdiflvvgnwklisqlgqkgrdfvvlnmpveesdaspahsQAPHAIFCLVLMVALMLTDE---IPNPVAAIIACLLMGK 452
Cdd:COG0471  173 -----------------------------------------REKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 453 FRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYGPYMMMVCLFVMCATIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654546230 533 APIALAMAKSMGVSPYPFAMMVAMAASAAFMTPVSSPVNTLVLGPGNYKFSDFVKLGVPFTVLVMVVCVVLIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 304-392 5.57e-11

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 60.71  E-value: 5.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 304 EQLLEPMVLRGEYFSDQALDVGMAEVSLIPESELLGKTVREMGFRTRYGLNVVGLKRDGVAMEGAVVDEPILLGDIFLVV 383
Cdd:COG0490   48 LLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVV 127


                 ....*....
gi 654546230 384 GNWKLISQL 392
Cdd:COG0490  128 GTREQLERL 136
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 214-289 1.54e-07

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 50.69  E-value: 1.54e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654546230 214 RRTFRDLIKEYRLTgRARRLAIRPGSPMVGQRLDDLKLRERYGANVIGVerwRRFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490   55 RLLTRLLIELVLLL-AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAI---RRGGEVILSPGPDTVLEAGDTLVV 126
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 1.32e-58

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 200.38  E-value: 1.32e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  61 AALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQS-----SPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSekrskFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFSVTPLGLVILAMGVVYMLLTRfalkgdkqdknkegwkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 216 tfrdlikeyrltgrarrlairpgspmvgqrlddlklreryganvigverWRRFRRVIVNVNGVSEfrardvllidmstad 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKE--------------- 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 296 vdlrefcseqllepmvlrgeyfsdqaldvgmaevslipeseLLGKTVREMGFRTRyglnvvglkrdgvamegavvdepil 375
Cdd:COG0471  159 -----------------------------------------VIREELAELGPLSR------------------------- 172

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 376 lgdiflvvgnwklisqlgqkgrdfvvlnmpveesdaspahsQAPHAIFCLVLMVALMLTDE---IPNPVAAIIACLLMGK 452
Cdd:COG0471  173 -----------------------------------------REKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 453 FRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYGPYMMMVCLFVMCATIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654546230 533 APIALAMAKSMGVSPYPFAMMVAMAASAAFMTPVSSPVNTLVLGPGNYKFSDFVKLGVPFTVLVMVVCVVLIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 19-197 3.06e-54

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 189.33  E-value: 3.06e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  19 FATGKVRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYL 98
Cdd:cd01115   11 FVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  99 MLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFSV 178
Cdd:cd01115   91 MLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGFSFFEF 170

                        170
                 ....*....|....*....
gi 654546230 179 TPLGLVILAMGVVYMLLTR 197
Cdd:cd01115  171 TPIGLPLLIIGLLYLWFIF 189
CitMHS pfam03600
Citrate transporter;
19-216 2.91e-41

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 152.85  E-value: 2.91e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   19 FATGKVRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYL 98
Cdd:pfam03600   4 IITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   99 MLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELiREGFQGFSFFSV 178
Cdd:pfam03600  84 MLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASAL-GLSFGDFGFFMF 162

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 654546230  179 TPLGLVILAMGVVYMLLTRFALKGDKQDKNKEGWKRRT 216
Cdd:pfam03600 163 PPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRK 200
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 28-186 7.61e-13

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 70.84  E-value: 7.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   28 AVALFVI-VAFVLSGTLTLP---EAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKM-LIYLMLTV 102
Cdd:TIGR00785  33 VTALLAIpIIAVLLGVLSAFkfkNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLET 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  103 AGLGAFMSSTGVV-AIFIPVVLSVSMRMQSSPSR--------LMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGF 173
Cdd:TIGR00785 113 LLAPMWPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIQI 192

                         170
                  ....*....|....*..
gi 654546230  174 SFFS----VTPLGLVIL 186
Cdd:TIGR00785 193 SWGDwflaGLPLGIILL 209
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 304-392 5.57e-11

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 60.71  E-value: 5.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 304 EQLLEPMVLRGEYFSDQALDVGMAEVSLIPESELLGKTVREMGFRTRYGLNVVGLKRDGVAMEGAVVDEPILLGDIFLVV 383
Cdd:COG0490   48 LLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVV 127


                 ....*....
gi 654546230 384 GNWKLISQL 392
Cdd:COG0490  128 GTREQLERL 136
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-392 4.86e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 50.30  E-value: 4.86e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654546230  326 MAEVSLIPESELLGKTVREMGFRTRYGLNVVGLKRDGVaMEGAVVDEPILLGDIFLVVGNWKLISQL 392
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR-LIIPSGDTVLEAGDRLLVIGTPDDLAAL 66
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 214-289 1.54e-07

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 50.69  E-value: 1.54e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654546230 214 RRTFRDLIKEYRLTgRARRLAIRPGSPMVGQRLDDLKLRERYGANVIGVerwRRFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490   55 RLLTRLLIELVLLL-AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAI---RRGGEVILSPGPDTVLEAGDTLVV 126
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 1.56e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 45.68  E-value: 1.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654546230  231 RRLAIRPGSPMVGQRLDDLKLRERYGANVIGVERWRRfrrvIVNVNGVSEFRARDVLLIDMSTADVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR----LIIPSGDTVLEAGDRLLVIGTPDDLA 64
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
61-610 1.32e-58

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 200.38  E-value: 1.32e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  61 AALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQS-----SPSR 135
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSekrskFGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 136 LMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFSVTPLGLVILAMGVVYMLLTRfalkgdkqdknkegwkrr 215
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVL------------------ 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 216 tfrdlikeyrltgrarrlairpgspmvgqrlddlklreryganvigverWRRFRRVIVNVNGVSEfrardvllidmstad 295
Cdd:COG0471  143 -------------------------------------------------YRLLPPEIKEVPGSKE--------------- 158

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 296 vdlrefcseqllepmvlrgeyfsdqaldvgmaevslipeseLLGKTVREMGFRTRyglnvvglkrdgvamegavvdepil 375
Cdd:COG0471  159 -----------------------------------------VIREELAELGPLSR------------------------- 172

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 376 lgdiflvvgnwklisqlgqkgrdfvvlnmpveesdaspahsQAPHAIFCLVLMVALMLTDE---IPNPVAAIIACLLMGK 452
Cdd:COG0471  173 -----------------------------------------REKIALAIFALTVLLWITGSlhgIPIAVVALLGAVLLLL 211

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 453 FRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYGPYMMMVCLFVMCATIGLFISNTATAVLM 532
Cdd:COG0471  212 TGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTATAALL 291

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654546230 533 APIALAMAKSMGVSPYPFAMMVAMAASAAFMTPVSSPVNTLVLGPGNYKFSDFVKLGVPFTVLVMVVCVVLIPVLFPF 610
Cdd:COG0471  292 LPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 19-197 3.06e-54

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 189.33  E-value: 3.06e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  19 FATGKVRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYL 98
Cdd:cd01115   11 FVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  99 MLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFSV 178
Cdd:cd01115   91 MLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGFSFFEF 170

                        170
                 ....*....|....*....
gi 654546230 179 TPLGLVILAMGVVYMLLTR 197
Cdd:cd01115  171 TPIGLPLLIIGLLYLWFIF 189
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 418-608 9.78e-43

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 157.75  E-value: 9.78e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 418 APHAIFCLVLMVALMLTDEIPNPVAAIIACLLMGK---FRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVK 494
Cdd:cd01115  189 FRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVlvfGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 495 GLMDVGGGYGPYMMMVCLFVMCATIGLFISNTATAVLMAPIALAMAKSMGVSPYPFAMMVAMAASAAFMTPVSSPVNTLV 574
Cdd:cd01115  269 ALISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIV 348

                        170       180       190
                 ....*....|....*....|....*....|....
gi 654546230 575 LGPGNYKFSDFVKLGVPFTVLVMVVCVVLIPVLF 608
Cdd:cd01115  349 LGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
CitMHS pfam03600
Citrate transporter;
19-216 2.91e-41

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 152.85  E-value: 2.91e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   19 FATGKVRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYL 98
Cdd:pfam03600   4 IITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   99 MLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELiREGFQGFSFFSV 178
Cdd:pfam03600  84 MLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASAL-GLSFGDFGFFMF 162

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 654546230  179 TPLGLVILAMGVVYMLLTRFALKGDKQDKNKEGWKRRT 216
Cdd:pfam03600 163 PPVGVALLLVGLLPLLLIFRKLLPVRKEEEAELEELRK 200
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 19-206 1.42e-31

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 126.60  E-value: 1.42e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  19 FATGKVRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKmLIYL 98
Cdd:cd00625    4 IRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRL-LLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  99 MLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSP-SRLMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFS 177
Cdd:cd00625   83 MLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPpVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFLDFLAFMA 162

                        170       180
                 ....*....|....*....|....*....
gi 654546230 178 VTPLGLVILAMGVVYMLLTRFALKGDKQD 206
Cdd:cd00625  163 PPALGLLLLLLGLLYLLFRKKLLLPDEDK 191
CitMHS pfam03600
Citrate transporter;
399-547 1.47e-21

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 96.23  E-value: 1.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  399 FVVLNMPVEESDASPAHSQAPHAIFCLVLMVALMLTDEIPNPVAAIIACLLMGKFRCIDAESAYKAIHWPSIILIVGMMP 478
Cdd:pfam03600 186 PVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFI 265

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 654546230  479 FALALQKTGGVDLIVKGLmdvGGGYGPYMMMVCLFVMCATIGLFISNTATAVLMAPIALAMAKSMGVSP 547
Cdd:pfam03600 266 LVGALEKTGLADALADAL---GGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
CitMHS pfam03600
Citrate transporter;
429-591 2.12e-17

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 83.90  E-value: 2.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  429 VALMLTDEIPNPVAAIIACLLMGKFRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYgPYMM 508
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK-PRRL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  509 MVCLFVMCATIGLFISNTATAVLMAPIALAMAKSMGVSPYPFAMMVAMAASA-AFMTPVSSPVNTLVLGPGNYKFSDFVK 587
Cdd:pfam03600  80 LVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIgGTATPIGDPPNIIIASALGLSFGDFGF 159


                  ....
gi 654546230  588 LGVP 591
Cdd:pfam03600 160 FMFP 163
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
28-195 2.09e-15

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 78.27  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  28 AVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVK-VAGSSETKMLIYLMLTVAGLG 106
Cdd:COG0471  200 VVALLGAVLLLLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLT 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 107 AFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLiSGMMTLVATPPNLVV-------NSELIREGFqgfsffsvt 179
Cdd:COG0471  280 EFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAAS-CAFLLPVGTPPNAIVygsgyykFKDFLKVGL--------- 349

                        170
                 ....*....|....*.
gi 654546230 180 PLGLVILAMGVVYMLL 195
Cdd:COG0471  350 PLNLIGLVVLLLLGPL 365
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
421-591 2.31e-14

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 75.16  E-value: 2.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 421 AIFCLVLMVALMLTDEIPNPVAAIIACLLMGKFRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVG 500
Cdd:COG1055    7 AIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 501 GGyGPYMMMVCLFVMCATIGLFISNTATAVLMAPIALAMAKSMGVSPYPFAMMVAMAA-SAAFMTPVSSPVNTLVLGPGN 579
Cdd:COG1055   87 KG-SPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAAnIGGAATPIGNPTNIMIASAGG 165

                        170
                 ....*....|...
gi 654546230 580 YKFSDFVK-LGVP 591
Cdd:COG1055  166 LSFLDFLAnLFPP 178
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
20-219 4.13e-14

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 74.39  E-value: 4.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  20 ATGKVRMD--AVALFVIVAFVLSGTLTLPEAFSGFsDPNVI-LIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLI 96
Cdd:COG1055   17 ILEPRGLNraVAALLGAALLLLLGVVSLEDALEAI-DWNTIlFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLW 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  97 YLMLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSeliregFQGFSFF 176
Cdd:COG1055   96 LLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTNIMIAS------AGGLSFL 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 654546230 177 S-VTPLGLVILAMGVVYMLLTRFALKGD-KQDKNKEGWKRRTFRD 219
Cdd:COG1055  170 DfLANLFPPSLVSLLVTLLVLYLLFRKElPAAPDLEDDPKEAIKD 214
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 430-610 4.14e-14

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 74.59  E-value: 4.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 430 ALMLTDEIPNPVAAIIACLLMGKFRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYGPYMMM 509
Cdd:cd00625    2 VLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 510 VCLFVmcATIGLFISNTATAVLMAPIALAMAKSMGVSPYPFAMMVAMAASAA--FMTPVSSPVNTLVLGPGNYKFSDFVK 587
Cdd:cd00625   82 LMLLT--AALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIggAATPIGNPPNLIIASLSGLGFLDFLA 159

                        170       180
                 ....*....|....*....|...
gi 654546230 588 LGVPFTVLVMVVCVVLIPVLFPF 610
Cdd:cd00625  160 FMAPPALGLLLLLLGLLYLLFRK 182
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 425-591 6.40e-13

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 70.69  E-value: 6.40e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 425 LVLMVALMLTDEIPNPVAAIIACLLMGKFRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYG 504
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 505 PYMMMVcLFVMCATIGLFISNTATAVLMAPIALAMAKSMGVSPYP-FAMMVAMAASAAFMTPVSSPVNTLV------LGP 577
Cdd:cd01115   84 RRLLLL-LMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRlLMPLAFAASIGGMLTLIGTPPNLVAsgylesLGG 162

                        170
                 ....*....|....
gi 654546230 578 GNYKFSDFVKLGVP 591
Cdd:cd01115  163 QGFSFFEFTPIGLP 176
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 28-186 7.61e-13

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 70.84  E-value: 7.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   28 AVALFVI-VAFVLSGTLTLP---EAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKM-LIYLMLTV 102
Cdd:TIGR00785  33 VTALLAIpIIAVLLGVLSAFkfkNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLET 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  103 AGLGAFMSSTGVV-AIFIPVVLSVSMRMQSSPSR--------LMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGF 173
Cdd:TIGR00785 113 LLAPMWPSNTARAgGILLPIIKSLLPLLGSKPEKsprkigkyLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIQI 192

                         170
                  ....*....|....*..
gi 654546230  174 SFFS----VTPLGLVIL 186
Cdd:TIGR00785 193 SWGDwflaGLPLGIILL 209
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 19-195 3.27e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 68.38  E-value: 3.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  19 FATGKVRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVA-GSSETKMLIY 97
Cdd:cd01115  206 AITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISLLgGLPPFAILLL 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  98 LMLTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGlISGMMTLVATPPNLVVNSElirEGFQGFSFFS 177
Cdd:cd01115  286 LCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGA-SCAFMLPVGTPPNAIVLGP---GGYKFSDFAK 361

                        170
                 ....*....|....*....
gi 654546230 178 V-TPLGLVILAMGVVYMLL 195
Cdd:cd01115  362 VgLPLSILSLVVSVTMIPL 380
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 28-210 1.07e-11

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 66.92  E-value: 1.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  28 AVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSEtKMLIYLMLTVAGLGA 107
Cdd:cd01117   15 AIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPR-RLLFLLVLLSGILSA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 108 FMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELiREGFQGFSFFSVTPLGLVILA 187
Cdd:cd01117   94 LLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIASES-GISFPFFLAAMAPLALLGLLL 172

                        170       180
                 ....*....|....*....|...
gi 654546230 188 MGVVYMLLTRFALKGDKQDKNKE 210
Cdd:cd01117  173 LLILLLVLFPGELKGLPLDKATK 195
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 28-193 4.34e-11

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 64.96  E-value: 4.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  28 AVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLGA 107
Cdd:cd00625  233 ALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSN 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 108 FMSSTGVVAIFIPVVLSVsmrmqSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELIREG--FQGFSFFSVT-PLGLV 184
Cdd:cd00625  313 FISNVPTVALLLPIAASL-----APPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGvgISFGEFLKVGlPLTLL 387


                 ....*....
gi 654546230 185 ILAMGVVYM 193
Cdd:cd00625  388 SLVVSLLYL 396
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 304-392 5.57e-11

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 60.71  E-value: 5.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 304 EQLLEPMVLRGEYFSDQALDVGMAEVSLIPESELLGKTVREMGFRTRYGLNVVGLKRDGVAMEGAVVDEPILLGDIFLVV 383
Cdd:COG0490   48 LLLGELLRLLTRLLIELVLLLAIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAGDTLVVV 127


                 ....*....
gi 654546230 384 GNWKLISQL 392
Cdd:COG0490  128 GTREQLERL 136
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 437-593 9.29e-10

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 61.21  E-value: 9.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  437 IPNPVAAIIACLLMGKFRCIDAESAYK-AIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYGPYM-MMVCLFV 514
Cdd:TIGR00785 270 INASVVALLAVVLMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIaVLVLVVL 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  515 MCATIGLFISNTATAVLMAPIALAMAKSMGVSPYPFAMMVAMAA-SAAFMTPVSSPVNTLVLGPGNYKFSDFVKLGVPFT 593
Cdd:TIGR00785 350 FYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSAsLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIG 429
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 28-192 1.19e-09

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 60.82  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   28 AVALFVIVAFVLSGTLTLPEAFSGFSDPNV-ILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLI--YLMLTVAG 104
Cdd:TIGR00785 274 VVALLAVVLMLFLGIVTWKDIQKNKVAWNTlILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVlvLVVLFYII 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  105 LGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVV-------NSELIREGFQgFSFFS 177
Cdd:TIGR00785 354 LYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMGFLTPYATPPNAIAygsgyvkIKDMWRVGAI-IGIVG 432

                         170
                  ....*....|....*
gi 654546230  178 VtplgLVILAMGVVY 192
Cdd:TIGR00785 433 L----IVLLLVGTLW 443
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 28-195 2.40e-08

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 56.49  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  28 AVALFVIVAFVLSGTLTLPEAFSgFSDPNVI-LIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLG 106
Cdd:cd01116   21 AGALWLVILGLATLSPDLETIVS-WVDWETLaLLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLS 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 107 AFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSEliregfQGFSFFSVTPLGL--V 184
Cdd:cd01116  100 AFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGSA------AGLTFNDFLLHMLpsV 173

                        170
                 ....*....|.
gi 654546230 185 ILAMGVVYMLL 195
Cdd:cd01116  174 VLALVVTFILL 184
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 425-608 3.57e-08

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 56.11  E-value: 3.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 425 LVLMVALMLTDEIPNPVAAIIACLLMGKFRCIDAESAYKAIH----WPSIILIVGMMPFALALQKTGGVD-LIVKGLMDV 499
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLSPDLETIVswvdWETLALLLGMMIIVSILSETGVFEyLAIWAVKIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 500 GGGYGPYMMMVCLFVmcATIGLFISNTATAVLMAPIALAMAKSMGVSPYPFAMMVAMAA-SAAFMTPVSSPVNTLVLGPG 578
Cdd:cd01116   81 KGRPWRLLLLLGLLT--AFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAAnIGGAATLIGDPPNIMIGSAA 158

                        170       180       190
                 ....*....|....*....|....*....|
gi 654546230 579 NYKFSDFVKLGVPFTVLVMVVCVVLIPVLF 608
Cdd:cd01116  159 GLTFNDFLLHMLPSVVLALVVTFILLYFLY 188
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 326-392 4.86e-08

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 50.30  E-value: 4.86e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654546230  326 MAEVSLIPESELLGKTVREMGFRTRYGLNVVGLKRDGVaMEGAVVDEPILLGDIFLVVGNWKLISQL 392
Cdd:pfam02080   1 LVEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR-LIIPSGDTVLEAGDRLLVIGTPDDLAAL 66
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 214-289 1.54e-07

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 50.69  E-value: 1.54e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654546230 214 RRTFRDLIKEYRLTgRARRLAIRPGSPMVGQRLDDLKLRERYGANVIGVerwRRFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG0490   55 RLLTRLLIELVLLL-AIEEVKVPPGSPLVGKTLGELNLRQRTGVTVVAI---RRGGEVILSPGPDTVLEAGDTLVV 126
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 23-194 4.49e-07

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 52.64  E-value: 4.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  23 KVRMDAVALF-VIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLT 101
Cdd:cd01116  238 GVSLGWIALLgALLLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWI 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 102 VAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQgFSFFSVTPL 181
Cdd:cd01116  318 SALLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYK-ISFWEFLKV 396

                        170
                 ....*....|....*..
gi 654546230 182 GLVI----LAMGVVYML 194
Cdd:cd01116  397 GFPImlvsLILATVYLL 413
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
29-195 5.27e-07

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 52.44  E-value: 5.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  29 VALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLGAF 108
Cdd:COG1055  245 IALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAV 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 109 MSSTGVVAIFIPVVLSVSMRMQSSPsrLMMPLSFAGLISGMMTLVATPPNLVVnSELIREGFQGFSFFS----VTPLGLV 184
Cdd:COG1055  325 VDNVPLVAALLPLIPDLGATGNPEP--LWLALALGATLGGNLTPIGSAANVIV-LGIAEKKGIKISFGEflkvGLPLTLL 401

                        170
                 ....*....|.
gi 654546230 185 ILAMGVVYMLL 195
Cdd:COG1055  402 TLLIALLYLLL 412
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 436-610 1.26e-06

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 51.12  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 436 EIPNPVAAIIACLLMGKFRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGgyGPYMMMVCLFVM 515
Cdd:cd01117   10 RLDRWAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAG--SPRRLLFLLVLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 516 CATIGLFISNTATAVLMAPIALAMAKSMGVSPYPFAMMVAMAASA-AFMTPVSSPVNTLVLGPGNYKFSDFVKLGVPFTV 594
Cdd:cd01117   88 SGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIgSAATPIGNPQNLLIASESGISFPFFLAAMAPLAL 167

                        170
                 ....*....|....*.
gi 654546230 595 LVMVVCVVLIPVLFPF 610
Cdd:cd01117  168 LGLLLLLILLLVLFPG 183
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 231-297 1.56e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 45.68  E-value: 1.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654546230  231 RRLAIRPGSPMVGQRLDDLKLRERYGANVIGVERWRRfrrvIVNVNGVSEFRARDVLLIDMSTADVD 297
Cdd:pfam02080   2 VEVTVPENSPLVGKTLKELNLPERFGVRIVAIRRGGR----LIIPSGDTVLEAGDRLLVIGTPDDLA 64
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
24-289 2.11e-06

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 50.44  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  24 VRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVA 103
Cdd:COG3273  107 DIGLPEAMRAALPEAVETLVRATVAASSALAGRTLLLILLETETGVRVIAIRRGDDWLLNPGPTTILRADDLVLLRGPEG 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 104 GLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFSVTPLGL 183
Cdd:COG3273  187 GILEVYLAATGDLYERPRPPEDSIVEMKNLSELAVDLAYSSVLFDSEELAEEVRELEEEVDALKSRLEAWVLRAARRVDD 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 184 VILAMGVVYMLLTRFALKGDKQDKNkegwkRRTFRDLIKEYRLTG-------RARRLAIRPGSPMVGQRLDDLKLRERYG 256
Cdd:COG3273  267 PVALRGLLHLASSTEVISDAALDIA-----EGVLRGLEDHPVVAEavresdeRIVRVTVPPGSPLVGKTLGELKLETETG 341

                        250       260       270
                 ....*....|....*....|....*....|...
gi 654546230 257 ANVIGVerwRRFRRVIVNVNGVSEFRARDVLLI 289
Cdd:COG3273  342 VRVIAI---RRGGGWIYDPDGDTRLRAGDVLIV 371
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 26-194 3.85e-06

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 49.68  E-value: 3.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   26 MDAVALFVIVAF-VLSGTLT---LPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLT 101
Cdd:pfam00939  51 MAVIALFAISLSaILIGTLLakaLSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFS 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  102 VAGLGAFMSSTGV--VAIFIPVVLSVSMRMQSSP---------SRLMMPLSFAGLISGMMTLVATPPNLVVnSELIRE-- 168
Cdd:pfam00939 131 DLLLAPATPSNTAraGGIVFPIIMSLPPAFGSDPekgserrigAYLMWTVYQSTSITSAMFLTAMAPNLLL-LGLMNSil 209

                         170       180       190
                  ....*....|....*....|....*....|.
gi 654546230  169 GF-----QGFSFFSVTPLGLVILAMGVVYML 194
Cdd:pfam00939 210 GVtitwaSWFLAAIPPGVILLLLAPLLLYVL 240
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
26-386 4.44e-06

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 49.28  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  26 MDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGL 105
Cdd:COG3273   31 IDLAYSAVLDESDALAEEVLELELRMDVLQLLARMSLLLAARALEEAELLAPVLGVVAAAVAISAAAGDIAKVVLEDIGL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 106 GAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVVNSELIREGFQGFSFFSVTPLGLVI 185
Cdd:COG3273  111 PEAMRAALPEAVETLVRATVAASSALAGRTLLLILLETETGVRVIAIRRGDDWLLNPGPTTILRADDLVLLRGPEGGILE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 186 LAMGVVYMLLTRFALKGDKQDKNKEGwkrrtfRDLIKEYRLTG-RARRLAIRPGSPMVGQRLDDLKLRERY-----GANV 259
Cdd:COG3273  191 VYLAATGDLYERPRPPEDSIVEMKNL------SELAVDLAYSSvLFDSEELAEEVRELEEEVDALKSRLEAwvlraARRV 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 260 IGVERWRRFRRVIVNVNGVSEFRArdvllidmSTADVDLREFCSEQLLEPMVLRGEYfsdqaldvGMAEVSLIPESELLG 339
Cdd:COG3273  265 DDPVALRGLLHLASSTEVISDAAL--------DIAEGVLRGLEDHPVVAEAVRESDE--------RIVRVTVPPGSPLVG 328

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 654546230 340 KTVREMGFRTRYGLNVVGLKRDGVAMEGAVVDEPILLGDIFLVVGNW 386
Cdd:COG3273  329 KTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTR 375
CitMHS pfam03600
Citrate transporter;
20-133 4.66e-06

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 48.85  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   20 ATGKVRMDAVALFVIVAFVLSGTLTLPEAFSGFSDPNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSseTKMLIYLM 99
Cdd:pfam03600 220 ILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLSGL--LVALALIL 297

                          90       100       110
                  ....*....|....*....|....*....|....
gi 654546230  100 LTVAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSP 133
Cdd:pfam03600 298 WLSALLSAFISNVPTAALMAPIIVGMAPAAGLGD 331
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 421-588 4.15e-05

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 46.10  E-value: 4.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 421 AIFCLVLMVALMLTDEIPNPVAAIIACLLMGKFRCIDAESAYKAIH--WPSIILIVGMMPFALALQKTGGVDLIVKGLMD 498
Cdd:cd01118    4 AIFVLTLVLVIWRPFGLPEAVWAVLGAVIALILGLVSPHDALEVWGivWDVTLTLIGVILLSLLLDEEGFFEWVAALAAR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 499 VGGGyGPYMMMVCLFVMCATIGLFISNTATAVLMAPIALAMAKSMGVSPY---PFAMMVAMAASAAFMT-PVSSPVNTLV 574
Cdd:cd01118   84 WARG-SGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKNrtlPFLYACAFIADAASLPlPISNLVNIVT 162

                        170
                 ....*....|....
gi 654546230 575 LGPGNYKFSDFVKL 588
Cdd:cd01118  163 AGYFGIGFTEYAAL 176
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 229-288 4.80e-05

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 45.44  E-value: 4.80e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 229 RARRLAIRPGSPMVGQRLDDLKLRERYGANVIGVERwrrfRRVIVNVNGVSEFRARDVLL 288
Cdd:COG0569  241 EIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKR----GGEVIIPSGDTVLEAGDELI 296
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 306-362 2.05e-04

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 43.52  E-value: 2.05e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 654546230 306 LLEPMVLrgEYFSDQALDVGMAEVSLIPESELLGKTVREMGFRTRYGLNVVGLKRDG 362
Cdd:COG0569  224 LLRPGVL--DVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERYGVTVVAIKRGG 278
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 467-593 3.29e-04

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 43.51  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  467 WPSIILIVGMMPFALALQKTGGVDLIVKGLMDVGGGYGPYM-MMVCLFVMCATIGLFISNTATAVLMAPIALAMAKSMGV 545
Cdd:pfam00939 322 WNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMaFIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPG 401

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 654546230  546 SPYPFAMMVAMAAS--AAFMTPVSSPVNTLVLGPGNYKFSDFVKLGVPFT 593
Cdd:pfam00939 402 APPLLAALLLGFAIslGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILT 451
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 416-549 3.54e-04

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 43.49  E-value: 3.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  416 SQAPHAIFCLVLMVALMLTDEIPNPVAAIIACLLM----GKFRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDL 491
Cdd:TIGR00785   8 SGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIavllGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKR 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 654546230  492 IVKGLMDVGGGYGPYMMMVCLFVMCATIGLFISNTA-TAVLMAPIALAMAKSMGVSPYP 549
Cdd:TIGR00785  88 IAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKPEK 146
DctM pfam06808
Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a ...
 28-157 2.44e-03

Tripartite ATP-independent periplasmic transporter, DctM component; This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers. Note that many family members are hypothetical proteins.


Pssm-ID: 284275 [Multi-domain]  Cd Length: 413  Bit Score: 40.70  E-value: 2.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   28 AVALFVIVAFVLSGTLTLPEAFSGFSDPN------VILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETkMLIYLMLT 101
Cdd:pfam06808 241 AVVYALLIGVLVYRRLTLEEVAAALLQTAkttaavLFILAAAGIFAGLLTITGVPFKLSDWLLSLGGGNLL-FLILVNLL 319

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 654546230  102 VAGLGAFMSSTGVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMmtlvaTPP 157
Cdd:pfam06808 320 CLVLGMFLDPTAAIIILVPILAPAAAQLGIDPIHFGVVIVYNGSIGLI-----TPP 370
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 35-201 3.92e-03

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 39.94  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230  35 VAFVLSGTLTLPEAFSGFSD--PNVILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLGAFMSST 112
Cdd:cd01118   31 VIALILGLVSPHDALEVWGIvwDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFAND 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 113 GVVAIFIPVVLSVSMRMQSSPSRLMMPLSFAGLISGMMTLVATPPNLVvnsELIREGFQGFSFFSVT-----PLGLVILA 187
Cdd:cd01118  111 GTALILTPIVIALLRALGAKKNRTLPFLYACAFIADAASLPLPISNLV---NIVTAGYFGIGFTEYAalmflPSIVSILA 187

                        170
                 ....*....|....
gi 654546230 188 MGVVYMLLTRFALK 201
Cdd:cd01118  188 TYVVLYLFFRRALP 201
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 28-161 7.59e-03

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 39.28  E-value: 7.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230   28 AVALFVIVAFVLSGTLTLPEAFSGFSDPN-VILIAALFIIGDGLVRTGVATIMGAWLVKVAGSSETKMLIYLMLTVAGLG 106
Cdd:pfam00939 295 TVAIIGLALMLLLRILDWKDIVKNKGAWNtLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLS 374

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 654546230  107 --AFMSSTGVVAIFIPVVLSVSMRMQSSPSRL-MMPLSFAGLISGMMTLVATPPNLVV 161
Cdd:pfam00939 375 hyLFASATAHTAAMLPIFAAVAQAIPGAPPLLaALLLGFAISLGGFLTPYGTGPGPIY 432
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
422-593 8.19e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 38.96  E-value: 8.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 422 IFCLVLMVALMLTDEIPNPVA--AIIACLLMGKFRCIDAESAYKAIHWPSIILIVGMMPFALALQKTGGVDLIVKGLMDV 499
Cdd:COG1055  223 LVLALLLVGFVLHSFLGLPPAliALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASL 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546230 500 GGGYGPYMMMVCLFVMcATIGLFISNTATAVLMAPialaMAKSMGVSPYPFAMMVAMAASAAF---MTPVSSPVNTLVLG 576
Cdd:COG1055  303 TGGNLLLAALLILWLS-AILSAVVDNVPLVAALLP----LIPDLGATGNPEPLWLALALGATLggnLTPIGSAANVIVLG 377

                        170       180
                 ....*....|....*....|..
gi 654546230 577 -----PGNYKFSDFVKLGVPFT 593
Cdd:COG1055  378 iaekkGIKISFGEFLKVGLPLT 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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