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Conserved domains on  [gi|654546848|ref|WP_028014554|]
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MULTISPECIES: serine-type D-Ala-D-Ala carboxypeptidase [Enterobacter]

Protein Classification

D-alanyl-D-alanine carboxypeptidase( domain architecture ID 10013735)

D-alanyl-D-alanine carboxypeptidase catalyzes the peptide bond cleavage of D-alanyl-D-alanine to form D-alanine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK11113 PRK11113
D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional
1-477 0e+00

D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional


:

Pssm-ID: 182972  Cd Length: 477  Bit Score: 958.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   1 MRFSSFIIGLTTSITFTAQAANVDEYINQLPAGANLALMVQKVGAQAPEIDYHSQQMALPASTQKVITALAALLQLGPDF 80
Cdd:PRK11113   1 MRFSRIIIGLTSLISFSVQAANVDEYITQLPAGANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALLQLGPDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  81 RFTTTLETKGNVDGGELKGDLIARFGGDPTFKRQDIRNMVAVLKKSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQCF 160
Cdd:PRK11113  81 RFTTTLETKGKVENGVLKGDLIARFGGDPTLTRQDLRNMVATLKKSGVKQIDGNLLIDTSVFASHDRAPGWPWNDLTQCF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 161 SAPPAAAIVDRNCFSISLYSAPKPDDLAFIRVASYYPVTMFSQVRTLAKGSPDAQYCELDVVPGDLNRYTLTGCLTQRAD 240
Cdd:PRK11113 161 SAPPAAAIVDRNCFSVSLYSAPKPGDRAFIRVPSYYPVTVFSQVRTLPRGSAEAQYCELDVVPGDLNRYTLTGCLPQRSK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 241 PLPLAFAIQDGASYAGAILKDELKQAGITYSGTLLRQTQVNQPGTVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMIGH 320
Cdd:PRK11113 241 PLPLAFAVQDGASYAGAILKDELKQAGIELSGKILRQTQPNKPGTVLASHQSAPLHDLLKIMLKKSDNMIADTLFRTIGH 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 321 ARFGVPGTWRAGSDAVRQILRQQAGIDLGNTIAVDGSGLSRHNLIAPATMMQVLQYIAQHDTELNFISMLPLAGHDGSLQ 400
Cdd:PRK11113 321 ERFNVPGTFRAGSDAVRQILRQQAGIDLGNTIIADGSGLSRHNLIAPATMMQVLQYIAQHDKELNLISMLPLAGYDGTLQ 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654546848 401 YRAGLHAAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPTDQRNRRIPLVRFESRLYKDIYQNN 477
Cdd:PRK11113 401 YRGGLHQAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQFLSGYAVPPADQRNRRIPLVRFESRLYKDLYQNN 477
 
Name Accession Description Interval E-value
PRK11113 PRK11113
D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional
1-477 0e+00

D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional


Pssm-ID: 182972  Cd Length: 477  Bit Score: 958.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   1 MRFSSFIIGLTTSITFTAQAANVDEYINQLPAGANLALMVQKVGAQAPEIDYHSQQMALPASTQKVITALAALLQLGPDF 80
Cdd:PRK11113   1 MRFSRIIIGLTSLISFSVQAANVDEYITQLPAGANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALLQLGPDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  81 RFTTTLETKGNVDGGELKGDLIARFGGDPTFKRQDIRNMVAVLKKSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQCF 160
Cdd:PRK11113  81 RFTTTLETKGKVENGVLKGDLIARFGGDPTLTRQDLRNMVATLKKSGVKQIDGNLLIDTSVFASHDRAPGWPWNDLTQCF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 161 SAPPAAAIVDRNCFSISLYSAPKPDDLAFIRVASYYPVTMFSQVRTLAKGSPDAQYCELDVVPGDLNRYTLTGCLTQRAD 240
Cdd:PRK11113 161 SAPPAAAIVDRNCFSVSLYSAPKPGDRAFIRVPSYYPVTVFSQVRTLPRGSAEAQYCELDVVPGDLNRYTLTGCLPQRSK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 241 PLPLAFAIQDGASYAGAILKDELKQAGITYSGTLLRQTQVNQPGTVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMIGH 320
Cdd:PRK11113 241 PLPLAFAVQDGASYAGAILKDELKQAGIELSGKILRQTQPNKPGTVLASHQSAPLHDLLKIMLKKSDNMIADTLFRTIGH 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 321 ARFGVPGTWRAGSDAVRQILRQQAGIDLGNTIAVDGSGLSRHNLIAPATMMQVLQYIAQHDTELNFISMLPLAGHDGSLQ 400
Cdd:PRK11113 321 ERFNVPGTFRAGSDAVRQILRQQAGIDLGNTIIADGSGLSRHNLIAPATMMQVLQYIAQHDKELNLISMLPLAGYDGTLQ 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654546848 401 YRAGLHAAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPTDQRNRRIPLVRFESRLYKDIYQNN 477
Cdd:PRK11113 401 YRGGLHQAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQFLSGYAVPPADQRNRRIPLVRFESRLYKDLYQNN 477
Peptidase_S13 pfam02113
D-Ala-D-Ala carboxypeptidase 3 (S13) family; This family of serine peptidases belong to MEROPS ...
20-469 0e+00

D-Ala-D-Ala carboxypeptidase 3 (S13) family; This family of serine peptidases belong to MEROPS peptidase family S13 (D-Ala-D-Ala carboxypeptidase C, clan SE). The active site residues occur in the motif SXXK. D-Ala-D-Ala carboxypeptidase C is involved in the metabolism of cell components. There are three families of serine-type D-Ala-D-Ala peptidase (designated S11, S12 and S13), which are also known as low molecular weight penicillin-binding proteins. Family S13 comprises D-Ala-D-Ala peptidases that have sufficient sequence similarity around their active sites to assume a distant evolutionary relationship to other clan members; members of the S13 family also bind penicillin and have D-amino-peptidase activity.


Pssm-ID: 396611  Cd Length: 444  Bit Score: 557.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   20 AANVDEYINQlPA--GANLALMVQKVGAQAPEIDYHSQQMALPASTQKVITALAALLQLGPDFRFTTTLETKGNVDGGEL 97
Cdd:pfam02113   2 QANLDAHLAD-PAleGANAGVAVQDADTGQELYDYNGDTPLLPASTQKLLTAAAALLTLGPNFRFTTEVVANGTVNNGNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   98 KGDLIARFGGDPTFKRQDIRNMVAVLKKSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCFSIS 177
Cdd:pfam02113  81 DGNLYLVGSGDPTLSAEDLDALAAQLKDSGVTPIEGDLVVDDSLFASPDLAPGWPWADLTYGYSAPINAAMIDAGCVIVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  178 LYSaPKPDDLAFIRVASYYPVTMFSQVRTlaKGSPDAQYCELDVVPGDLNRYTLTGCLTQRADPLPLAFAIQDGASYAGA 257
Cdd:pfam02113 161 LTP-QNPGEPATITVPPPIPIAQFQNVAV--TTAAEPHYCLLDVVPFGTNTLVVTGCLPPDAEPRPLSRAVQDPAAYAGA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  258 ILKDELKQAGITYSGTLLRQTQVnQPGTVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMIGHARfGVPGTWRAGSDAVR 337
Cdd:pfam02113 238 IFAKALAKQGITVSGDVGIATAP-QGARVLAVHQSAPLSDLLKKMMKKSDNLIAESLFREIGVAI-KRPGSFEAGTDAVR 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  338 QILrQQAGIDLGNTIAVDGSGLSRHNLIAPATMMQVLQYIAQHDTELNFISMLPLAGHDGSLQYRAGLHAAGVDGKVSAK 417
Cdd:pfam02113 316 SRL-QTAGIDTANLVLRDGSGLSRHNLVTAATLAQLLQAIADQPWLQALLDSLPVAGESGTLRNRFKLTSTPAVGKVRAK 394
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 654546848  418 TGSLQGVYNLAGFITTASGQRMAFVQYLSGyaVEPTDQRNRRIPLVRFESRL 469
Cdd:pfam02113 395 TGSLTGVYSLAGYVTTASGRKLAFSFILNG--LGAADGKNIRDAMDGLLANL 444
PBP4 TIGR00666
D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; In E. coli, this protein is ...
45-447 5.59e-180

D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; In E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 200042 [Multi-domain]  Cd Length: 333  Bit Score: 507.03  E-value: 5.59e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   45 AQAPEIDYHSQQMALPASTQKVITALAALLQLGPDFRFTTTLETKGNVDGGELKGDLIARFGGDPTFKRQDIRNMVAVLK 124
Cdd:TIGR00666   1 TSQPLYDYHGDTFMLPASTQKVITAAAALLQLGPNFRFTTTVETKGNVENGNLKGNLVLRFGGDPTLKRQDIRNMVATLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  125 KSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCfsislysapkpddlafirvasyypvtmfsqv 204
Cdd:TIGR00666  81 KSGVTQIDGNVLVDTSAFSSHDRAPGWPWNDLTQCFSAPPAAAIIDANC------------------------------- 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  205 rtlakgspdaqyceldvvpgdlnrytltgcltqradPLPLAFAIQDGASYAGAILKDELKQAGITYSGTLLrQTQVNQPG 284
Cdd:TIGR00666 130 ------------------------------------PQPLTFAVQRPASYALDLLQQLLKQQGISVAGVIL-ASEPPQAG 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  285 TVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMIGHArFGVPGTWRAGSDAVRQILrQQAGIDLGNTIAVDGSGLSRHNL 364
Cdd:TIGR00666 173 QVLASHQSAPLHDLLKIMMKKSDNMIAETLFREIGHA-FNRPGSWQAGVDAVRSIL-QQAGVDTGNTILADGSGLSRHNL 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  365 IAPATMMQVLQYIAQHDTELNFISMLPLAGHDGSLQYRAGLHAAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQY 444
Cdd:TIGR00666 251 VAPATLMQVLQYIAQQSNELNYLSSLPVAGYDGTLGERAGLHDTPLVGKVRAKTGSLTGVYSLAGFITTASGQKLAFVQY 330

                  ...
gi 654546848  445 LSG 447
Cdd:TIGR00666 331 LNG 333
DacB COG2027
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
7-477 2.78e-162

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441630  Cd Length: 464  Bit Score: 467.08  E-value: 2.78e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   7 IIGLTTSITFTAQAANVDEYINQL-----PAGANLALMVQKVGAQAPEIDYHSQQMALPASTQKVITALAALLQLGPDFR 81
Cdd:COG2027    1 LLALLLLLALLASAAALPAALDALladpgLGGASVGVVVVDLDTGEVLYSRNADRPLTPASTMKLLTTAAALELLGPDYR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  82 FTTTLETKGNVDGGELKGDLIARFGGDPTFKRQD---IRNMVAVLKKSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQ 158
Cdd:COG2027   81 FKTTVYADGTIRDGVLNGNLYLVGGGDPTLSSEDaagLWDLAAQLKAAGIRRINGDLVLDDSLFDGPALAPGWFWDDLGR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 159 CFSAPPAAAIVDRNCFSISLYSAPKPDDLAFIRVASYYPVTMFSQVRTlAKGSPDAQYCELDvvpGDLNRYTLTGCLTQR 238
Cdd:COG2027  161 GYGAPPSALMVNENAVRLTLRPGAAGGPARVSVEPPLAGVTIDNQVKT-AAGSGDTLDVYRA---PGGNRLVLTGTLPAG 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 239 ADPLPLAFAIQDGASYAGAILKDELKQAGITYSGTlLRQTQVNQPGTVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMI 318
Cdd:COG2027  237 CGEFTLSLAVPDPALYAARAFAAALAAAGITVTGK-VRRGTAPAGARLLAEVQSPPLAELVRDMNKESDNLYAEALLRTL 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 319 GHARFGVPGTWRAGSDAVRQILRqQAGIDLGNTIAVDGSGLSRHNLIAPATMMQVLQYIAQHDTELNFISMLPLAGHDGS 398
Cdd:COG2027  316 GAERTGAPGSFAGGAAAVRAFLA-ELGIDTSGLVLVDGSGLSRYNRVTARALAQLLQAAARSPWLPEFLASLPVAGVDGT 394
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 654546848 399 LQYRagLHAAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPTDQRnrriplvRFESRLYKDIYQNN 477
Cdd:COG2027  395 LRNR--FKGTPAAGRVRAKTGTLTGVSALAGYVTTADGRRLAFSILVNNYNASAAEAR-------AALDALLAALARCG 464
 
Name Accession Description Interval E-value
PRK11113 PRK11113
D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional
1-477 0e+00

D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional


Pssm-ID: 182972  Cd Length: 477  Bit Score: 958.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   1 MRFSSFIIGLTTSITFTAQAANVDEYINQLPAGANLALMVQKVGAQAPEIDYHSQQMALPASTQKVITALAALLQLGPDF 80
Cdd:PRK11113   1 MRFSRIIIGLTSLISFSVQAANVDEYITQLPAGANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALLQLGPDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  81 RFTTTLETKGNVDGGELKGDLIARFGGDPTFKRQDIRNMVAVLKKSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQCF 160
Cdd:PRK11113  81 RFTTTLETKGKVENGVLKGDLIARFGGDPTLTRQDLRNMVATLKKSGVKQIDGNLLIDTSVFASHDRAPGWPWNDLTQCF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 161 SAPPAAAIVDRNCFSISLYSAPKPDDLAFIRVASYYPVTMFSQVRTLAKGSPDAQYCELDVVPGDLNRYTLTGCLTQRAD 240
Cdd:PRK11113 161 SAPPAAAIVDRNCFSVSLYSAPKPGDRAFIRVPSYYPVTVFSQVRTLPRGSAEAQYCELDVVPGDLNRYTLTGCLPQRSK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 241 PLPLAFAIQDGASYAGAILKDELKQAGITYSGTLLRQTQVNQPGTVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMIGH 320
Cdd:PRK11113 241 PLPLAFAVQDGASYAGAILKDELKQAGIELSGKILRQTQPNKPGTVLASHQSAPLHDLLKIMLKKSDNMIADTLFRTIGH 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 321 ARFGVPGTWRAGSDAVRQILRQQAGIDLGNTIAVDGSGLSRHNLIAPATMMQVLQYIAQHDTELNFISMLPLAGHDGSLQ 400
Cdd:PRK11113 321 ERFNVPGTFRAGSDAVRQILRQQAGIDLGNTIIADGSGLSRHNLIAPATMMQVLQYIAQHDKELNLISMLPLAGYDGTLQ 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654546848 401 YRAGLHAAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPTDQRNRRIPLVRFESRLYKDIYQNN 477
Cdd:PRK11113 401 YRGGLHQAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQFLSGYAVPPADQRNRRIPLVRFESRLYKDLYQNN 477
Peptidase_S13 pfam02113
D-Ala-D-Ala carboxypeptidase 3 (S13) family; This family of serine peptidases belong to MEROPS ...
20-469 0e+00

D-Ala-D-Ala carboxypeptidase 3 (S13) family; This family of serine peptidases belong to MEROPS peptidase family S13 (D-Ala-D-Ala carboxypeptidase C, clan SE). The active site residues occur in the motif SXXK. D-Ala-D-Ala carboxypeptidase C is involved in the metabolism of cell components. There are three families of serine-type D-Ala-D-Ala peptidase (designated S11, S12 and S13), which are also known as low molecular weight penicillin-binding proteins. Family S13 comprises D-Ala-D-Ala peptidases that have sufficient sequence similarity around their active sites to assume a distant evolutionary relationship to other clan members; members of the S13 family also bind penicillin and have D-amino-peptidase activity.


Pssm-ID: 396611  Cd Length: 444  Bit Score: 557.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   20 AANVDEYINQlPA--GANLALMVQKVGAQAPEIDYHSQQMALPASTQKVITALAALLQLGPDFRFTTTLETKGNVDGGEL 97
Cdd:pfam02113   2 QANLDAHLAD-PAleGANAGVAVQDADTGQELYDYNGDTPLLPASTQKLLTAAAALLTLGPNFRFTTEVVANGTVNNGNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   98 KGDLIARFGGDPTFKRQDIRNMVAVLKKSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCFSIS 177
Cdd:pfam02113  81 DGNLYLVGSGDPTLSAEDLDALAAQLKDSGVTPIEGDLVVDDSLFASPDLAPGWPWADLTYGYSAPINAAMIDAGCVIVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  178 LYSaPKPDDLAFIRVASYYPVTMFSQVRTlaKGSPDAQYCELDVVPGDLNRYTLTGCLTQRADPLPLAFAIQDGASYAGA 257
Cdd:pfam02113 161 LTP-QNPGEPATITVPPPIPIAQFQNVAV--TTAAEPHYCLLDVVPFGTNTLVVTGCLPPDAEPRPLSRAVQDPAAYAGA 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  258 ILKDELKQAGITYSGTLLRQTQVnQPGTVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMIGHARfGVPGTWRAGSDAVR 337
Cdd:pfam02113 238 IFAKALAKQGITVSGDVGIATAP-QGARVLAVHQSAPLSDLLKKMMKKSDNLIAESLFREIGVAI-KRPGSFEAGTDAVR 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  338 QILrQQAGIDLGNTIAVDGSGLSRHNLIAPATMMQVLQYIAQHDTELNFISMLPLAGHDGSLQYRAGLHAAGVDGKVSAK 417
Cdd:pfam02113 316 SRL-QTAGIDTANLVLRDGSGLSRHNLVTAATLAQLLQAIADQPWLQALLDSLPVAGESGTLRNRFKLTSTPAVGKVRAK 394
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 654546848  418 TGSLQGVYNLAGFITTASGQRMAFVQYLSGyaVEPTDQRNRRIPLVRFESRL 469
Cdd:pfam02113 395 TGSLTGVYSLAGYVTTASGRKLAFSFILNG--LGAADGKNIRDAMDGLLANL 444
PBP4 TIGR00666
D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; In E. coli, this protein is ...
45-447 5.59e-180

D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; In E. coli, this protein is known as penicillin binding protein 4 (dacB). A signal sequence is cleaved from a precursor form. The protein is described as periplasmic in E. coli (Gram-negative) and extracellular in Actinomadura R39 (Gram-positive). Unlike some other proteins with similar activity, it does not form transpeptidation. It is not essential for viability. This family is related to class A beta-lactamases. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 200042 [Multi-domain]  Cd Length: 333  Bit Score: 507.03  E-value: 5.59e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   45 AQAPEIDYHSQQMALPASTQKVITALAALLQLGPDFRFTTTLETKGNVDGGELKGDLIARFGGDPTFKRQDIRNMVAVLK 124
Cdd:TIGR00666   1 TSQPLYDYHGDTFMLPASTQKVITAAAALLQLGPNFRFTTTVETKGNVENGNLKGNLVLRFGGDPTLKRQDIRNMVATLK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  125 KSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCfsislysapkpddlafirvasyypvtmfsqv 204
Cdd:TIGR00666  81 KSGVTQIDGNVLVDTSAFSSHDRAPGWPWNDLTQCFSAPPAAAIIDANC------------------------------- 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  205 rtlakgspdaqyceldvvpgdlnrytltgcltqradPLPLAFAIQDGASYAGAILKDELKQAGITYSGTLLrQTQVNQPG 284
Cdd:TIGR00666 130 ------------------------------------PQPLTFAVQRPASYALDLLQQLLKQQGISVAGVIL-ASEPPQAG 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  285 TVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMIGHArFGVPGTWRAGSDAVRQILrQQAGIDLGNTIAVDGSGLSRHNL 364
Cdd:TIGR00666 173 QVLASHQSAPLHDLLKIMMKKSDNMIAETLFREIGHA-FNRPGSWQAGVDAVRSIL-QQAGVDTGNTILADGSGLSRHNL 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  365 IAPATMMQVLQYIAQHDTELNFISMLPLAGHDGSLQYRAGLHAAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQY 444
Cdd:TIGR00666 251 VAPATLMQVLQYIAQQSNELNYLSSLPVAGYDGTLGERAGLHDTPLVGKVRAKTGSLTGVYSLAGFITTASGQKLAFVQY 330

                  ...
gi 654546848  445 LSG 447
Cdd:TIGR00666 331 LNG 333
DacB COG2027
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
7-477 2.78e-162

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441630  Cd Length: 464  Bit Score: 467.08  E-value: 2.78e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848   7 IIGLTTSITFTAQAANVDEYINQL-----PAGANLALMVQKVGAQAPEIDYHSQQMALPASTQKVITALAALLQLGPDFR 81
Cdd:COG2027    1 LLALLLLLALLASAAALPAALDALladpgLGGASVGVVVVDLDTGEVLYSRNADRPLTPASTMKLLTTAAALELLGPDYR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848  82 FTTTLETKGNVDGGELKGDLIARFGGDPTFKRQD---IRNMVAVLKKSGVTKIDGNVLIDTSIFASHDKAPGWPWNDMTQ 158
Cdd:COG2027   81 FKTTVYADGTIRDGVLNGNLYLVGGGDPTLSSEDaagLWDLAAQLKAAGIRRINGDLVLDDSLFDGPALAPGWFWDDLGR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 159 CFSAPPAAAIVDRNCFSISLYSAPKPDDLAFIRVASYYPVTMFSQVRTlAKGSPDAQYCELDvvpGDLNRYTLTGCLTQR 238
Cdd:COG2027  161 GYGAPPSALMVNENAVRLTLRPGAAGGPARVSVEPPLAGVTIDNQVKT-AAGSGDTLDVYRA---PGGNRLVLTGTLPAG 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 239 ADPLPLAFAIQDGASYAGAILKDELKQAGITYSGTlLRQTQVNQPGTVIASKQSPPLHDLLRIMLKKSDNMIADTVFRMI 318
Cdd:COG2027  237 CGEFTLSLAVPDPALYAARAFAAALAAAGITVTGK-VRRGTAPAGARLLAEVQSPPLAELVRDMNKESDNLYAEALLRTL 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 319 GHARFGVPGTWRAGSDAVRQILRqQAGIDLGNTIAVDGSGLSRHNLIAPATMMQVLQYIAQHDTELNFISMLPLAGHDGS 398
Cdd:COG2027  316 GAERTGAPGSFAGGAAAVRAFLA-ELGIDTSGLVLVDGSGLSRYNRVTARALAQLLQAAARSPWLPEFLASLPVAGVDGT 394
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 654546848 399 LQYRagLHAAGVDGKVSAKTGSLQGVYNLAGFITTASGQRMAFVQYLSGYAVEPTDQRnrriplvRFESRLYKDIYQNN 477
Cdd:COG2027  395 LRNR--FKGTPAAGRVRAKTGTLTGVSALAGYVTTADGRRLAFSILVNNYNASAAEAR-------AALDALLAALARCG 464
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
294-475 8.25e-07

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 50.28  E-value: 8.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 294 PLHDLLRIMLKKSDNMIADTVFRmigharfgvpgtwRAGSDAVRQILRQ--------QAGIDLGNTIAVDGSglsrhNLI 365
Cdd:COG2367  109 TLRELAELMITVSDNTATNLLLR-------------LLGPDAVNAFLRSlgltdtrlDRKEPDLNELPGDGR-----NTT 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546848 366 APATMMQVLQYIAQHD------TELnFISMLpLAGHDGSLqYRAGLhAAGVdgKVSAKTGSLQGVYNLAGFITTASGQRM 439
Cdd:COG2367  171 TPRDMARLLAALYRGEllspesRAR-LLDWL-ARQTGRDR-LRAGL-PEGW--RVAHKTGTGGGVRNDVGIVWPPDGKPY 244
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 654546848 440 AFVQYLSGYAvEPTDQRNRRIplvrfeSRLYKDIYQ 475
Cdd:COG2367  245 VLAVFTKGPD-ADAARAEALI------AEIARAVYD 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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