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Conserved domains on  [gi|654546863|ref|WP_028014569|]
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MULTISPECIES: lipopolysaccharide ABC transporter substrate-binding protein LptA [Enterobacter]

Protein Classification

lipopolysaccharide transport periplasmic protein LptA( domain architecture ID 10013673)

lipopolysaccharide ABC transporter substrate-binding protein LptA plays a role in the delivery of lipopolysaccharide to the outer leaflet of the outer membrane

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10894 PRK10894
lipopolysaccharide ABC transporter substrate-binding protein LptA;
5-184 5.51e-121

lipopolysaccharide ABC transporter substrate-binding protein LptA;


:

Pssm-ID: 182816 [Multi-domain]  Cd Length: 180  Bit Score: 339.04  E-value: 5.51e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863   5 TNKLSLKVIIASAMLAASLPALAVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGEQGKE 84
Cdd:PRK10894   1 TNKLSLNLLLASSLLAASIPAFALTGDTDQPIHIDSDQQSLDMQGNVVTFTGNVVVTQGTIKINADKVVVTRPGGEQGKE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  85 IIDGYGNPATFYQMQDNGKPVKGHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQASSEKGKRVTTVL 164
Cdd:PRK10894  81 VIDGYGNPATFYQMQDNGKPVKGHASKMHYELAKDFVVLTGNAYLEQLDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVL 160
                        170       180
                 ....*....|....*....|
gi 654546863 165 VPSQLQDKGKGQAPAQKKSN 184
Cdd:PRK10894 161 VPSQLQDKNKGQTPAQKKSN 180
 
Name Accession Description Interval E-value
PRK10894 PRK10894
lipopolysaccharide ABC transporter substrate-binding protein LptA;
5-184 5.51e-121

lipopolysaccharide ABC transporter substrate-binding protein LptA;


Pssm-ID: 182816 [Multi-domain]  Cd Length: 180  Bit Score: 339.04  E-value: 5.51e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863   5 TNKLSLKVIIASAMLAASLPALAVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGEQGKE 84
Cdd:PRK10894   1 TNKLSLNLLLASSLLAASIPAFALTGDTDQPIHIDSDQQSLDMQGNVVTFTGNVVVTQGTIKINADKVVVTRPGGEQGKE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  85 IIDGYGNPATFYQMQDNGKPVKGHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQASSEKGKRVTTVL 164
Cdd:PRK10894  81 VIDGYGNPATFYQMQDNGKPVKGHASKMHYELAKDFVVLTGNAYLEQLDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVL 160
                        170       180
                 ....*....|....*....|
gi 654546863 165 VPSQLQDKGKGQAPAQKKSN 184
Cdd:PRK10894 161 VPSQLQDKNKGQTPAQKKSN 180
outer_YhbN_LptA TIGR03002
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ...
27-167 1.45e-63

lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]


Pssm-ID: 274384 [Multi-domain]  Cd Length: 142  Bit Score: 192.44  E-value: 1.45e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863   27 AVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGeQGKEIIDGYGNPATFYQMQDNGKPVK 106
Cdd:TIGR03002   1 ALTSDREQPIHIEADSQTLDDKKGVVTFTGNVVITQGTLKIRADKVVVTRNDA-GGIEKATATGKPATFRQKLDNGKEIE 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 654546863  107 GHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQASSEKGK--RVTTVLVPS 167
Cdd:TIGR03002  80 GQANRIEYDPAKDEVVLTGNARLKQGGNEISGDVITYDTKKQKVIAKGDGGKtgRVTTIIQPK 142
LptA COG1934
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
11-175 2.11e-60

Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441537 [Multi-domain]  Cd Length: 164  Bit Score: 185.12  E-value: 2.11e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  11 KVIIASAMLAASLPALAVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGeQGKEIIDGYG 90
Cdd:COG1934    1 LLLLALLLLLLAAPALAQKADRDQPIEIEADRLEVDDKKGTAVFTGNVVVTQGTLTLRADKLVVYYDKA-GGIERIEATG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  91 NpATFYQMQDNGKPVKGHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQA-SSEKGKRVTTVLVPSQL 169
Cdd:COG1934   80 N-VTFRQKRDGGQEVEATADRAEYDVATDTVVLTGNAVLTQGGNTVTGDRITYDLKTGRATAeGGGGGGRVRAVLQPKQK 158

                 ....*.
gi 654546863 170 QDKGKG 175
Cdd:COG1934  159 KDKKPA 164
LptD_N pfam03968
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in ...
37-149 5.16e-37

LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in lipopolysaccharide transport across the gram negative inner and outer membranes. The type examples for this family are E. coli LptA and the N-terminal domain of LptD.


Pssm-ID: 427621 [Multi-domain]  Cd Length: 113  Bit Score: 123.89  E-value: 5.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863   37 HIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGEQGKEIIDGYGnPATFYQMQDN-GKPVKGHASHMHYE 115
Cdd:pfam03968   1 EIEADNAELDDKKNVATFTGNVIVTQGTLTLRADKVIVTQDKKKNGPERLEATG-PATFRQKVDLvGRPIRGKADRIEYD 79
                          90       100       110
                  ....*....|....*....|....*....|....
gi 654546863  116 LAKDLVILTGNAYLEQLDSNITGDQITYLVKEQK 149
Cdd:pfam03968  80 VAKDIIVLTGNARLTQGGNSVRGDKITYDIKEQK 113
 
Name Accession Description Interval E-value
PRK10894 PRK10894
lipopolysaccharide ABC transporter substrate-binding protein LptA;
5-184 5.51e-121

lipopolysaccharide ABC transporter substrate-binding protein LptA;


Pssm-ID: 182816 [Multi-domain]  Cd Length: 180  Bit Score: 339.04  E-value: 5.51e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863   5 TNKLSLKVIIASAMLAASLPALAVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGEQGKE 84
Cdd:PRK10894   1 TNKLSLNLLLASSLLAASIPAFALTGDTDQPIHIDSDQQSLDMQGNVVTFTGNVVVTQGTIKINADKVVVTRPGGEQGKE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  85 IIDGYGNPATFYQMQDNGKPVKGHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQASSEKGKRVTTVL 164
Cdd:PRK10894  81 VIDGYGNPATFYQMQDNGKPVKGHASKMHYELAKDFVVLTGNAYLEQLDSNIKGDKITYLVKEQKMQAFSDKGKRVTTVL 160
                        170       180
                 ....*....|....*....|
gi 654546863 165 VPSQLQDKGKGQAPAQKKSN 184
Cdd:PRK10894 161 VPSQLQDKNKGQTPAQKKSN 180
outer_YhbN_LptA TIGR03002
lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include ...
27-167 1.45e-63

lipopolysaccharide transport periplasmic protein LptA; Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]


Pssm-ID: 274384 [Multi-domain]  Cd Length: 142  Bit Score: 192.44  E-value: 1.45e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863   27 AVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGeQGKEIIDGYGNPATFYQMQDNGKPVK 106
Cdd:TIGR03002   1 ALTSDREQPIHIEADSQTLDDKKGVVTFTGNVVITQGTLKIRADKVVVTRNDA-GGIEKATATGKPATFRQKLDNGKEIE 79
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 654546863  107 GHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQASSEKGK--RVTTVLVPS 167
Cdd:TIGR03002  80 GQANRIEYDPAKDEVVLTGNARLKQGGNEISGDVITYDTKKQKVIAKGDGGKtgRVTTIIQPK 142
LptA COG1934
Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];
11-175 2.11e-60

Lipopolysaccharide export system protein LptA [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441537 [Multi-domain]  Cd Length: 164  Bit Score: 185.12  E-value: 2.11e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  11 KVIIASAMLAASLPALAVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGeQGKEIIDGYG 90
Cdd:COG1934    1 LLLLALLLLLLAAPALAQKADRDQPIEIEADRLEVDDKKGTAVFTGNVVVTQGTLTLRADKLVVYYDKA-GGIERIEATG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  91 NpATFYQMQDNGKPVKGHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQA-SSEKGKRVTTVLVPSQL 169
Cdd:COG1934   80 N-VTFRQKRDGGQEVEATADRAEYDVATDTVVLTGNAVLTQGGNTVTGDRITYDLKTGRATAeGGGGGGRVRAVLQPKQK 158

                 ....*.
gi 654546863 170 QDKGKG 175
Cdd:COG1934  159 KDKKPA 164
LptD_N pfam03968
LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in ...
37-149 5.16e-37

LptA/(LptD N-terminal domain) LPS transport protein; This family of proteins are involved in lipopolysaccharide transport across the gram negative inner and outer membranes. The type examples for this family are E. coli LptA and the N-terminal domain of LptD.


Pssm-ID: 427621 [Multi-domain]  Cd Length: 113  Bit Score: 123.89  E-value: 5.16e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863   37 HIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGEQGKEIIDGYGnPATFYQMQDN-GKPVKGHASHMHYE 115
Cdd:pfam03968   1 EIEADNAELDDKKNVATFTGNVIVTQGTLTLRADKVIVTQDKKKNGPERLEATG-PATFRQKVDLvGRPIRGKADRIEYD 79
                          90       100       110
                  ....*....|....*....|....*....|....
gi 654546863  116 LAKDLVILTGNAYLEQLDSNITGDQITYLVKEQK 149
Cdd:pfam03968  80 VAKDIIVLTGNARLTQGGNSVRGDKITYDIKEQK 113
LptD COG1452
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
20-142 2.36e-12

LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441061 [Multi-domain]  Cd Length: 702  Bit Score: 64.24  E-value: 2.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654546863  20 AASLPALAVTGDTDQPIHIESDTQSLDMQGNVVTFTGNVVMTQGTIKINADKVVVTRPggeqgKEIIDGYGNPatfyQMQ 99
Cdd:COG1452    5 AQALSVPDLAPDDDAPVLIEADSLEYDQDDGTVTAEGNVEIRQGDRRLKADRVTYDQK-----TGTVTAEGNV----RLT 75
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 654546863 100 DNGKPVKGhaSHMHYEL-AKDLVILTGNAYLEQLDSNITGDQIT 142
Cdd:COG1452   76 DGGNVLTG--DEAELNLdTKDGFIENARYQLVDRGGRGAAERIK 117
PRK03761 PRK03761
LPS assembly outer membrane complex protein LptD; Provisional
28-80 1.22e-07

LPS assembly outer membrane complex protein LptD; Provisional


Pssm-ID: 235158 [Multi-domain]  Cd Length: 778  Bit Score: 50.69  E-value: 1.22e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 654546863  28 VTGDTDQ-PIHIESDTQSLDmQGNVVTFTGNVVMTQGTIKINADKVVVTRPGGE 80
Cdd:PRK03761  42 VTGDPNQlPVTIEADHAEAN-YPDDAVYTGNVDIKQGNSRLTADEVQLHQQENP 94
LptD COG1452
LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall ...
100-153 6.77e-04

LPS assembly outer membrane protein LptD (organic solvent tolerance protein OstA) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441061 [Multi-domain]  Cd Length: 702  Bit Score: 39.59  E-value: 6.77e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 654546863 100 DNGKPVKGHASHMHYELAKDLVILTGNAYLEQLDSNITGDQITYLVKEQKMQAS 153
Cdd:COG1452   16 DDDAPVLIEADSLEYDQDDGTVTAEGNVEIRQGDRRLKADRVTYDQKTGTVTAE 69
Planc_TIGR03067 TIGR03067
Planctomycetes uncharacterized domain TIGR03067; This domain occurs in several species, mostly ...
63-119 6.45e-03

Planctomycetes uncharacterized domain TIGR03067; This domain occurs in several species, mostly from the Planctomycetes division of the bacteria. It is expanded into a paralogous family of at least twenty-five members in Gemmata obscuriglobus UQM 2246. This family appears related to TIGR03066, which also is expanded into a large paralogous family in Gemmata obscuriglobus. [Unknown function, General]


Pssm-ID: 274415  Cd Length: 107  Bit Score: 35.04  E-value: 6.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 654546863   63 GTIKINADKVVVTRPGGEQGKEII--DGYGNPATFyQMQDNGKPVKGHASHMHYELAKD 119
Cdd:TIGR03067  31 LTVTFKGDKLTLKVGEGDPRVATIvlDPAANPKTI-DLVQPDGPEKGKPCKGIYKLEGD 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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