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Conserved domains on  [gi|654623347|ref|WP_028087757|]
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helix-turn-helix domain-containing protein [Dorea longicatena]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-85 4.93e-12

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 55.77  E-value: 4.93e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654623347 11 KNLISQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEGKEEKS 85
Cdd:COG1396   5 KKALGERLRELRKARGLTQEELAERL-----GVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEEL 74
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-85 4.93e-12

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 55.77  E-value: 4.93e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654623347 11 KNLISQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEGKEEKS 85
Cdd:COG1396   5 KKALGERLRELRKARGLTQEELAERL-----GVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEEL 74
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-77 1.67e-08

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 46.01  E-value: 1.67e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 654623347 15 SQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYL 77
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKL-----GVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
17-77 1.32e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 43.66  E-value: 1.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654623347   17 RLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYL 77
Cdd:smart00530  1 RLKELREEKGLTQEELAEKL-----GVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 16-83 1.28e-06

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 41.51  E-value: 1.28e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654623347  16 QRLIELRRQHNLSQRDLARQLQlhgydMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEGKEE 83
Cdd:pfam12844  2 ERLRKAREERGLTQEELAERLG-----ISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGEGE 64
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 15-80 9.44e-03

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 33.17  E-value: 9.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654623347  15 SQRLIELRRQHNLSQRDLARQLQLHGYDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEG 80
Cdd:PRK13355   5 AERLKQAMKARGLKQEDLVHAAEARGVKLGKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGG 70
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
11-85 4.93e-12

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 55.77  E-value: 4.93e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654623347 11 KNLISQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEGKEEKS 85
Cdd:COG1396   5 KKALGERLRELRKARGLTQEELAERL-----GVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEEL 74
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
11-82 5.12e-09

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 47.54  E-value: 5.12e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654623347 11 KNLISQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEGKE 82
Cdd:COG1476   2 KKKLGNRLKELRKERGLTQEELAELL-----GVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLEE 68
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 15-77 1.67e-08

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 46.01  E-value: 1.67e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 654623347 15 SQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYL 77
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKL-----GVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
17-77 1.32e-07

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 43.66  E-value: 1.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 654623347   17 RLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYL 77
Cdd:smart00530  1 RLKELREEKGLTQEELAEKL-----GVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 14-73 8.83e-07

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 42.23  E-value: 8.83e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 654623347 14 ISQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNIS 73
Cdd:COG1813  13 YGERIREAREARGLSQEELAEKL-----GVSESTIRRIERGEATPSLDTLRKLEKALGIS 67
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 16-83 1.28e-06

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 41.51  E-value: 1.28e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654623347  16 QRLIELRRQHNLSQRDLARQLQlhgydMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEGKEE 83
Cdd:pfam12844  2 ERLRKAREERGLTQEELAERLG-----ISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGEGE 64
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 18-77 5.28e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 39.83  E-value: 5.28e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 654623347  18 LIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYL 77
Cdd:pfam01381  1 LKELREELGLSQEELAEKL-----GVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 1-78 2.53e-03

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 33.84  E-value: 2.53e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654623347  1 MPKPKTSTGEKNLISQRLIELRRQHNLSQRDLARQLqlhgyDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLI 78
Cdd:COG3620   5 MSRDVVTVSPDDTLGEALRLMRKELGLSQLPVAELV-----GVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVL 77
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 16-73 5.57e-03

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 32.11  E-value: 5.57e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 654623347  16 QRLIELRRQHNLSQRDLARQLQlhgydMDKNVITRIETNKRYVTDVE-LKALTEIFNIS 73
Cdd:pfam13560  4 ARLRRLRERAGLSQEALARRLG-----VSRSTLSRLETGRRGRPSPAvVERLARALGVD 57
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 15-80 9.44e-03

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 33.17  E-value: 9.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654623347  15 SQRLIELRRQHNLSQRDLARQLQLHGYDMDKNVITRIETNKRYVTDVELKALTEIFNISYEYLIEG 80
Cdd:PRK13355   5 AERLKQAMKARGLKQEDLVHAAEARGVKLGKSHISQYVSGKTGPRRDVLPFLAAILGVSEDWLLGG 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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