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Conserved domains on  [gi|654680494|ref|WP_028139318|]
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MULTISPECIES: heme biosynthesis protein HemY [Bradyrhizobium]

Protein Classification

heme biosynthesis protein HemY( domain architecture ID 11467560)

heme biosynthesis protein HemY similar to Escherichia coli HemY, is found in heme biosynthesis gene clusters and contains tetratricopeptide repeats (TPRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 23-463 4.21e-160

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


:

Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 465.52  E-value: 4.21e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  23 DQPGDLVLTAGSFRASTTLPKFVFLLGLFAAAVVLVWSIVTTIWRTPGRLRRRRHDKRHARGRHAITHGLLAIGHGDTAL 102
Cdd:COG3898   23 DRPGTVSITWLGYEIETSLLVAAIALLVLAAAVWLLWRLLRFLLGSPTALSRYFRRRRRRKGYQALSRGLIAVAAGDGRL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 103 ARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRADDAVGAVMIAEEAIKLS 182
Cdd:COG3898  103 ARRKAAKAERLLDRPPLTLLLEAQAAQLAGDREAARRAFEAMLEDPETRFLGLRGLMVEALRRGDTEAALALAEEALALA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 183 PSSTWASHAVLGFRCARGDWSGALAILDSNLSAGQIDKQTYRRQRGVLLTARALELATMDRDVARESVMEAIKLAPTLVP 262
Cdd:COG3898  183 PKLPWAQDALLELQAAAGDWDGALATLDAALKAGLLDKDVARRRRAVLLTARARELEEGDPDEARELAIEALKLAPDLVP 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 263 AAVLAAKFESEAHQVRRAMKLVEAAWIANPHPDLADAYAHVKLGDTAWHRLQRVETLVAKtsadKPGHVEGQLAIARAAI 342
Cdd:COG3898  263 AAVLAARLLIAQGKLRKAAKVLEKAWRAQPHPDLAAAYAELRPGDSALDRLKRAETLAAL----NPDHPESRLALAEAAL 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 343 DASEFARAREVLAPYVK-DPTQRVALLMAEIERTEHGDGGRARAWTLRAVRARHDPAWTAD--GYVSDRWRPVSPVTGRL 419
Cdd:COG3898  339 AAGDFGEARRALGPLLEeRPTARVCLLMAEIERGEHGDDGRVREWLARALRAPRDPAWVCDacGTVSDDWAPVSPVCGRL 418

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 654680494 420 DAFQWQTPVASLPSDKGTT-----IESSAFEEAMLAAPPPKRVTVAPSE 463
Cdd:COG3898  419 DAFEWKTPPERLAAPPAEAemlplIVGLPAAEAEAAAPPAEAVPDDPVE 467
 
Name Accession Description Interval E-value
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 23-463 4.21e-160

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 465.52  E-value: 4.21e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  23 DQPGDLVLTAGSFRASTTLPKFVFLLGLFAAAVVLVWSIVTTIWRTPGRLRRRRHDKRHARGRHAITHGLLAIGHGDTAL 102
Cdd:COG3898   23 DRPGTVSITWLGYEIETSLLVAAIALLVLAAAVWLLWRLLRFLLGSPTALSRYFRRRRRRKGYQALSRGLIAVAAGDGRL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 103 ARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRADDAVGAVMIAEEAIKLS 182
Cdd:COG3898  103 ARRKAAKAERLLDRPPLTLLLEAQAAQLAGDREAARRAFEAMLEDPETRFLGLRGLMVEALRRGDTEAALALAEEALALA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 183 PSSTWASHAVLGFRCARGDWSGALAILDSNLSAGQIDKQTYRRQRGVLLTARALELATMDRDVARESVMEAIKLAPTLVP 262
Cdd:COG3898  183 PKLPWAQDALLELQAAAGDWDGALATLDAALKAGLLDKDVARRRRAVLLTARARELEEGDPDEARELAIEALKLAPDLVP 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 263 AAVLAAKFESEAHQVRRAMKLVEAAWIANPHPDLADAYAHVKLGDTAWHRLQRVETLVAKtsadKPGHVEGQLAIARAAI 342
Cdd:COG3898  263 AAVLAARLLIAQGKLRKAAKVLEKAWRAQPHPDLAAAYAELRPGDSALDRLKRAETLAAL----NPDHPESRLALAEAAL 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 343 DASEFARAREVLAPYVK-DPTQRVALLMAEIERTEHGDGGRARAWTLRAVRARHDPAWTAD--GYVSDRWRPVSPVTGRL 419
Cdd:COG3898  339 AAGDFGEARRALGPLLEeRPTARVCLLMAEIERGEHGDDGRVREWLARALRAPRDPAWVCDacGTVSDDWAPVSPVCGRL 418

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 654680494 420 DAFQWQTPVASLPSDKGTT-----IESSAFEEAMLAAPPPKRVTVAPSE 463
Cdd:COG3898  419 DAFEWKTPPERLAAPPAEAemlplIVGLPAAEAEAAAPPAEAVPDDPVE 467
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 29-132 1.73e-20

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 86.41  E-value: 1.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494   29 VLTAGSFRASTTLPKFVFLLGLFAAAVVLVWSIVTTIWRTPGRLRRRRHDKRHARGRHAITHGLLAIGHGDTALARRHAE 108
Cdd:pfam07219   1 LIVWGGYRIETSLWVAVLLLVLLFVLLYLLLRLLRLLLRLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAA 80

                          90       100
                  ....*....|....*....|....
gi 654680494  109 TARRHAPNDPLALLLHAQSAQLEG 132
Cdd:pfam07219  81 KAAKLLDAPLLNYLLAARAAQLQG 104
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 87-297 3.05e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494   87 AITHGLLA---IGHGDTALARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLF-IEA 162
Cdd:TIGR02917 465 ASLHNLLGaiyLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAgLYL 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  163 QRADDAVGAVMIaEEAIKLSPSSTWASHAVLGFRCARGDWSGALAILDSnLSAGQIDKQTYrrqrgVLLTARALeLATMD 242
Cdd:TIGR02917 545 RTGNEEEAVAWL-EKAAELNPQEIEPALALAQYYLGKGQLKKALAILNE-AADAAPDSPEA-----WLMLGRAQ-LAAGD 616

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 654680494  243 RDVARESVMEAIKLAPTLVPAAVLAAKFESEAHQVRRAMKLVEAAWIANPHPDLA 297
Cdd:TIGR02917 617 LNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEA 671
 
Name Accession Description Interval E-value
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 23-463 4.21e-160

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 465.52  E-value: 4.21e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  23 DQPGDLVLTAGSFRASTTLPKFVFLLGLFAAAVVLVWSIVTTIWRTPGRLRRRRHDKRHARGRHAITHGLLAIGHGDTAL 102
Cdd:COG3898   23 DRPGTVSITWLGYEIETSLLVAAIALLVLAAAVWLLWRLLRFLLGSPTALSRYFRRRRRRKGYQALSRGLIAVAAGDGRL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 103 ARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRADDAVGAVMIAEEAIKLS 182
Cdd:COG3898  103 ARRKAAKAERLLDRPPLTLLLEAQAAQLAGDREAARRAFEAMLEDPETRFLGLRGLMVEALRRGDTEAALALAEEALALA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 183 PSSTWASHAVLGFRCARGDWSGALAILDSNLSAGQIDKQTYRRQRGVLLTARALELATMDRDVARESVMEAIKLAPTLVP 262
Cdd:COG3898  183 PKLPWAQDALLELQAAAGDWDGALATLDAALKAGLLDKDVARRRRAVLLTARARELEEGDPDEARELAIEALKLAPDLVP 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 263 AAVLAAKFESEAHQVRRAMKLVEAAWIANPHPDLADAYAHVKLGDTAWHRLQRVETLVAKtsadKPGHVEGQLAIARAAI 342
Cdd:COG3898  263 AAVLAARLLIAQGKLRKAAKVLEKAWRAQPHPDLAAAYAELRPGDSALDRLKRAETLAAL----NPDHPESRLALAEAAL 338

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 343 DASEFARAREVLAPYVK-DPTQRVALLMAEIERTEHGDGGRARAWTLRAVRARHDPAWTAD--GYVSDRWRPVSPVTGRL 419
Cdd:COG3898  339 AAGDFGEARRALGPLLEeRPTARVCLLMAEIERGEHGDDGRVREWLARALRAPRDPAWVCDacGTVSDDWAPVSPVCGRL 418

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 654680494 420 DAFQWQTPVASLPSDKGTT-----IESSAFEEAMLAAPPPKRVTVAPSE 463
Cdd:COG3898  419 DAFEWKTPPERLAAPPAEAemlplIVGLPAAEAEAAAPPAEAVPDDPVE 467
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 29-132 1.73e-20

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 86.41  E-value: 1.73e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494   29 VLTAGSFRASTTLPKFVFLLGLFAAAVVLVWSIVTTIWRTPGRLRRRRHDKRHARGRHAITHGLLAIGHGDTALARRHAE 108
Cdd:pfam07219   1 LIVWGGYRIETSLWVAVLLLVLLFVLLYLLLRLLRLLLRLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAA 80

                          90       100
                  ....*....|....*....|....
gi 654680494  109 TARRHAPNDPLALLLHAQSAQLEG 132
Cdd:pfam07219  81 KAAKLLDAPLLNYLLAARAAQLQG 104
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 43-354 1.34e-12

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 68.78  E-value: 1.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  43 KFVFLLGLFAAAVVLVwsivttiwrtpgrlrrrrhdkrhargrhAITHGLLAIGHGDTALARRHAETARRHAPNDPLALL 122
Cdd:COG3071    3 RLLWLLLLLAAAVLLA----------------------------ALLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYL 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 123 LHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRAD-DAVGAVMIAEEAIKLSPSSTWASHAVLGFRCARGD 201
Cdd:COG3071   55 LAARAAQALGDYERRDEYLAQALELAPEAELAVLLTRAELLLDQgQAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGD 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 202 WSGALAILDSNLSAGQIDKQTYRRQRgVLLTARALELATMDRDVARE---SVMEAIKLAPTLvpaAVLAAKFESEAHQVR 278
Cdd:COG3071  135 WEELLELLPALRKHKALSAEEAQALE-RRAYLGLLRQAARDAEALKAlwkALPRAERRDPEL---AAAYARALIALGDHD 210

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654680494 279 RAMKLVEAAWIANPHPDLADAYAHVKLGDTAwHRLQRVETLVAKtsadKPGHVEGQLAIARAAIDASEFARAREVL 354
Cdd:COG3071  211 EAERLLREALKRQWDPRLVRLYGRLQGGDPA-KQLKRAEKWLKK----HPNDPDLLLALGRLCLRNQLWGKAREYL 281
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 91-359 2.68e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.45  E-value: 2.68e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  91 GLLAIGHGDTALARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRADDAVG 170
Cdd:COG2956   15 GLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 171 AVMIAEEAIKLSPSSTWASHAVLGFRCARGDWSGALAILDSNLSAGQIDKQTYRRQrgvlltARALeLATMDRDVARESV 250
Cdd:COG2956   95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCEL------AELY-LEQGDYDEAIEAL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 251 MEAIKLAPTLVPAAVLAAKFESEAHQVRRAMKLVEAAWIANP-----HPDLADAYAhvKLGDtawhrLQRVETLVAKTSA 325
Cdd:COG2956  168 EKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPdylpaLPRLAELYE--KLGD-----PEEALELLRKALE 240

                        250       260       270
                 ....*....|....*....|....*....|....
gi 654680494 326 DKPGHVEgQLAIARAAIDASEFARAREVLAPYVK 359
Cdd:COG2956  241 LDPSDDL-LLALADLLERKEGLEAALALLERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 87-297 3.05e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 3.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494   87 AITHGLLA---IGHGDTALARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLF-IEA 162
Cdd:TIGR02917 465 ASLHNLLGaiyLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAgLYL 544

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  163 QRADDAVGAVMIaEEAIKLSPSSTWASHAVLGFRCARGDWSGALAILDSnLSAGQIDKQTYrrqrgVLLTARALeLATMD 242
Cdd:TIGR02917 545 RTGNEEEAVAWL-EKAAELNPQEIEPALALAQYYLGKGQLKKALAILNE-AADAAPDSPEA-----WLMLGRAQ-LAAGD 616

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 654680494  243 RDVARESVMEAIKLAPTLVPAAVLAAKFESEAHQVRRAMKLVEAAWIANPHPDLA 297
Cdd:TIGR02917 617 LNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEA 671
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-368 2.25e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.30  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494   91 GLLAIGHGDTALARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAERE--DTRLLGLRGLFIEAQRadDA 168
Cdd:TIGR02917 302 GASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDpdDPAALSLLGEAYLALG--DF 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  169 VGAVMIAEEAIKLSPSSTwASHAVLG-FRCARGDWSGA------------------LAILDSNLSAGQIDKqtyrrqrgV 229
Cdd:TIGR02917 380 EKAAEYLAKATELDPENA-AARTQLGiSKLSQGDPSEAiadletaaqldpelgradLLLILSYLRSGQFDK--------A 450

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  230 LLTARALE-----------------LATMDRDVARESVMEAIKLAPTLVPAAVLAAKFESEAHQVRRAMKLVEAAWIANP 292
Cdd:TIGR02917 451 LAAAKKLEkkqpdnaslhnllgaiyLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDP 530

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  293 HpdlaDAYAHVKLGDTAwHRLQRVETLVA---KTSADKPGHVEGQLAIARAAIDASEFARAREVLAPYV---KDPTQRVA 366
Cdd:TIGR02917 531 K----NLRAILALAGLY-LRTGNEEEAVAwleKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAAdaaPDSPEAWL 605


                  ..
gi 654680494  367 LL 368
Cdd:TIGR02917 606 ML 607
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 99-355 1.42e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494   99 DTALARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRADDAVGAVMIAEEA 178
Cdd:TIGR02917 650 NYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKA 729

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  179 IKLSPSSTWAS--HAVLGfrcARGDWSGALAILDSNLSAGQIDKqtyrrqrgVLLTARA-LELATMDRDVARESVMEAIK 255
Cdd:TIGR02917 730 LKRAPSSQNAIklHRALL---ASGNTAEAVKTLEAWLKTHPNDA--------VLRTALAeLYLAQKDYDKAIKHYQTVVK 798

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  256 LAPTLVPA----AVLAAKF---ESEAHqVRRAMKLVEAAwianphPDLAD--AYAHVKLGDTAwhrlqRVETLVAKTSAD 326
Cdd:TIGR02917 799 KAPDNAVVlnnlAWLYLELkdpRALEY-AERALKLAPNI------PAILDtlGWLLVEKGEAD-----RALPLLRKAVNI 866

                         250       260
                  ....*....|....*....|....*....
gi 654680494  327 KPGHVEGQLAIARAAIDASEFARAREVLA 355
Cdd:TIGR02917 867 APEAAAIRYHLALALLATGRKAEARKELD 895
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
98-184 2.23e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  98 GDTALARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMaEREDTRLLGLRGLFIEAQRADDAVGAVMIAEE 177
Cdd:COG3063    6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEKAL-KLDPNNAEALLNLAELLLELGDYDEALAYLER 84


                 ....*..
gi 654680494 178 AIKLSPS 184
Cdd:COG3063   85 ALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 120-258 3.44e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 3.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 120 ALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRADDAVGAVMIAEEAIKLSPSSTWAsHAVLGFRCAR 199
Cdd:COG4783    6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEA-RLNLGLALLK 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494 200 -GDWSGALAILDSNLSAGQIDKQTYRRQrgvlltARALElATMDRDVARESVMEAIKLAP 258
Cdd:COG4783   85 aGDYDEALALLEKALKLDPEHPEAYLRL------ARAYR-ALGRPDEAIAALEKALELDP 137
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 91-183 4.54e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.86  E-value: 4.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680494  91 GLLAIGHGDTALARRHAETARRHAPNDPLALLLHAQSAQLEGNRDEAQRVFRAMAEREDTRLLGLRGLFIEAQRADDAVG 170
Cdd:COG4783   45 GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124

                         90
                 ....*....|...
gi 654680494 171 AVMIAEEAIKLSP 183
Cdd:COG4783  125 AIAALEKALELDP 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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