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Conserved domains on  [gi|654680645|ref|WP_028139469|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Bradyrhizobium]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
9-145 9.04e-30

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 105.44  E-value: 9.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645   9 DPQRLDNQICFAVYSAAHAFNRVYKPLLDRLGLTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVR 88
Cdd:COG1846    4 EPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 654680645  89 RTRSSEDERQVLIALTAQGHALKEKARSVPQSILAA--SDCSVSELVSMKDEIVALRDR 145
Cdd:COG1846   84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAEllAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
9-145 9.04e-30

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 105.44  E-value: 9.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645   9 DPQRLDNQICFAVYSAAHAFNRVYKPLLDRLGLTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVR 88
Cdd:COG1846    4 EPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 654680645  89 RTRSSEDERQVLIALTAQGHALKEKARSVPQSILAA--SDCSVSELVSMKDEIVALRDR 145
Cdd:COG1846   84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAEllAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-131 8.15e-24

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 88.81  E-value: 8.15e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645    36 LDRLGLTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSEDERQVLIALTAQGHALKEKAR 115
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*.
gi 654680645   116 SVPQSILAASDCSVSE 131
Cdd:smart00347  83 EARSETLAELLAGLTA 98
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 1.39e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 64.11  E-value: 1.39e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 654680645   41 LTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSEDERQV 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 19-113 8.55e-04

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 36.85  E-value: 8.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645   19 FAVYSAAHAFNRVYKPlldRLGLTYPQYLVM--LVLWERDD--VPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSE 94
Cdd:TIGR01889   4 LSLYLYIKSLKRYLKK---EFNLSLEELLILyyLGKLENNEgkLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90
                  ....*....|....*....
gi 654680645   95 DERQVLIALTAQGHALKEK 113
Cdd:TIGR01889  81 DERKVIISINKEQRSKIES 99
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
9-145 9.04e-30

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 105.44  E-value: 9.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645   9 DPQRLDNQICFAVYSAAHAFNRVYKPLLDRLGLTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVR 88
Cdd:COG1846    4 EPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 654680645  89 RTRSSEDERQVLIALTAQGHALKEKARSVPQSILAA--SDCSVSELVSMKDEIVALRDR 145
Cdd:COG1846   84 REPDPEDRRAVLVRLTEKGRALLEEARPALEALLAEllAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
36-131 8.15e-24

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 88.81  E-value: 8.15e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645    36 LDRLGLTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSEDERQVLIALTAQGHALKEKAR 115
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*.
gi 654680645   116 SVPQSILAASDCSVSE 131
Cdd:smart00347  83 EARSETLAELLAGLTA 98
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 41-99 1.39e-14

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 64.11  E-value: 1.39e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 654680645   41 LTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSEDERQV 99
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 39-98 1.43e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 51.05  E-value: 1.43e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645   39 LGLTYPQYLVMLVLWERDDVPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSEDERQ 98
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_27 pfam13463
Winged helix DNA-binding domain;
41-107 5.25e-07

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 44.59  E-value: 5.25e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654680645   41 LTYPQYLVMLVLWERDD-VPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSEDERQVLIALTAQG 107
Cdd:pfam13463   1 LTRLEALILHNIGHRGDpKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 48-148 3.57e-04

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 37.97  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645   48 VMLVLWERDDVPVKDI----GERLFLDSGTLTPLLKRLEAAHLVRRTRS----------SEDErqvLIALTAQGHALKEK 113
Cdd:pfam03965   8 VMEILWALGPATVKEVveelPEPKDWAYSTVKTLLTRLVKKGLLSREKDgrafiysplvSREE---YKAGQVKQLLDRFF 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 654680645  114 ARSVPQSILAASDcsvSELVSmKDEIVALRDRLNA 148
Cdd:pfam03965  85 GGSVPALVANFVE---REKLS-PDDIEELRQLLDQ 115
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 19-113 8.55e-04

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 36.85  E-value: 8.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654680645   19 FAVYSAAHAFNRVYKPlldRLGLTYPQYLVM--LVLWERDD--VPVKDIGERLFLDSGTLTPLLKRLEAAHLVRRTRSSE 94
Cdd:TIGR01889   4 LSLYLYIKSLKRYLKK---EFNLSLEELLILyyLGKLENNEgkLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90
                  ....*....|....*....
gi 654680645   95 DERQVLIALTAQGHALKEK 113
Cdd:TIGR01889  81 DERKVIISINKEQRSKIES 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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