|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-647 |
0e+00 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 975.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 1 MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLA 80
Cdd:PRK06599 1 MAKKLVIVESPAKAKTIKKYLGKDYKVLASFGHVRDLPKKKGGVDPDNDFAPKYEIIEGKEKVVDALKKAAKKADAVYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 81 ADPDREGEAIAWHLAHSLDVDIASDC---RVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKK 157
Cdd:PRK06599 81 TDPDREGEAIAWHIAEVLKEAKLKDKnvkRVVFNEITKKAVQEAIENPRDIDMDLVDAQQARRALDYLVGFKLSPLLWKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 158 VKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQ-FEGQLIEYQGKKVE---LSNEDDVTNIVKQLDG 233
Cdd:PRK06599 161 VRRGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGEpFTAKLVEVNGKKLEkfsITNEEQAKALVKALEG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 234 NEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGkEGTVGLITYMRTDSTRISETAQTE 313
Cdd:PRK06599 241 QAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEGIDLG-EGTVGLITYMRTDSVRLSNEALDE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 314 ARDYITNAYGNQFVATEKRKEKKNS-NAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMA 392
Cdd:PRK06599 320 ARKYITKKYGKEYLPAKPRVYKKKSkNAQEAHEAIRPTSINRTPESLKPYLTPDQFKLYELIWKRTVASQMAPAILDQTS 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 393 VDLK--NGDVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLE 470
Cdd:PRK06599 400 VDIAseNGKYVFRATGSVILFPGFLKVYGESKDDEEEDDEKLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKLE 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 471 ELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEF 550
Cdd:PRK06599 480 EYGIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIVNDFLVEHFPKYVDYDFTAGLEDELDEIAEGKKDWKPVLREF 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 551 YSDFEKRLEHAEKEMREVEIKDEPAGEDCEEC-GSPMVYKMGRYGKFMACSNFPDCRNTKPI-----------VKEIGVK 618
Cdd:PRK06599 560 WEPFISNLEKVEEDVRTEKVTQEETDETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNItrdedepieeeEIVEEEK 639
|
650 660 670
....*....|....*....|....*....|.
gi 654961648 619 CPKCEEGNIVerksKKKRT--FYGCDRFPGC 647
Cdd:PRK06599 640 CPKCGGPLVL----KKGRYgkFLACSGYPEC 666
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
5-612 |
0e+00 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 917.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLAADPD 84
Cdd:TIGR01051 1 LVIVESPAKAKTIKKYLGDEYEVEASMGHIRDLPKSRLGVDIEKDFEPEYVVSKGKKKVVKELKTLAKKADEVYLATDPD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 85 REGEAIAWHLAHSLDVDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSA 164
Cdd:TIGR01051 81 REGEAIAWHLAEVLKPKDPVYKRIVFNEITKKAIRAALKNPREIDMNLVNAQQARRILDRLVGYTLSPLLWKKVAKGLSA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 165 GRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKV---ELSNEDDVTNIVKQLDGNEFSISKV 241
Cdd:TIGR01051 161 GRVQSVALRLIVDREREIKRFVPEEYWTIDATFQKGEETFEALLTEVNGKKLkagSDLDEAEATALKEQLKGEELVVEEI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 242 TKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGkEGTVGLITYMRTDSTRISETAQTEARDYITNA 321
Cdd:TIGR01051 241 EKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGVSTG-DGTIGLITYMRTDSTRLSNQAVNEARNLIDKN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 322 YGNQFVATE-KRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKN--G 398
Cdd:TIGR01051 320 YGKEYLGPKpKRYKSKEKNAQEAHEAIRPTSVFRTPEELKDYLKRDEFRLYELIWKRFVASQMADARYDSTSVRLTNedG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 399 DVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPS 478
Cdd:TIGR01051 400 EYVFKATGRKLIFDGYYKVYVEGSDDPLEEKDRILPPLKEGDAVKLVEVKPNQHFTQPPARYTEASLVKELEELGIGRPS 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 479 TYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEKRL 558
Cdd:TIGR01051 480 TYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKMEKDLDEIAEGKAEWKPVLKNFYTGFSSKV 559
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 654961648 559 ehaEKEMREVEIKDEPAGEDCEECGSPMVYKMGRYGKFMACSNFPDCRNTKPIV 612
Cdd:TIGR01051 560 ---KKLRNMRIIVDFKTSQDCPLCGRPMVVKLGKYGPFLACSNFPECKYTKSIV 610
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
4-559 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 872.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 4 YLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLAADP 83
Cdd:COG0550 2 KLVIVESPAKAKTIAKYLGKDYVVTASVGHLRDLPKPELDVDVENDFEPKYEVIPGKKKQVKELKKLAKKADEVILATDP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 84 DREGEAIAWHLAHSLDVDiASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLS 163
Cdd:COG0550 82 DREGEAIAWHLLELLGDK-KPVKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRILDRLVGYNLSPLLWKKVKRGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 164 AGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKveLSNEDDVTNIVKQLDGNEFSISKVTK 243
Cdd:COG0550 161 AGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKIDGKK--ILDEEEAEAILAALKGKTFTVTSVEK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 244 RERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEgidlgkegtVGLITYMRTDSTRISETAQTEARDYITNAYG 323
Cdd:COG0550 239 KPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYE---------VGLITYMRTDSVRLSEDAVAAAREYIEALYG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 324 NQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEvkefLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFR 403
Cdd:COG0550 310 KEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPES----LSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFR 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 404 ANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPT 483
Cdd:COG0550 386 ASGKVIKFPGFLKVYGEGKDDEEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGIGRPSTYASI 465
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654961648 484 LDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEKRLE 559
Cdd:COG0550 466 IETLQDRGYVEREGKRLVPTELGFIVIDLLEEHFPDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
127-548 |
2.20e-169 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 490.99 E-value: 2.20e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 127 AINMDLVDAQQARRILDRLVGYNISPLLWKKVK--KGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQF 204
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKgnKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 205 EGQLIeyqgKKVELSNEDDVTNIVKQLDGNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEg 284
Cdd:pfam01131 81 ANAKW----KRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 285 idlgkegTVGLITYMRTDSTRISETAQ-TEARDYITNAYGNQF-----VATEKRKEKKNSNAQ-DAHEAIRPTsalrKPG 357
Cdd:pfam01131 156 -------KHGLITYPRTDSTYLSDDATlKAILEYLTKNYGKYLpyaprLLKKTKGKLTVGNAKvTAHEAIRPT----GDI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 358 EVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDdqveEKENLLPDLE 437
Cdd:pfam01131 225 PVLPELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKK----EDEEELPELK 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 438 EGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLElVLEFF 517
Cdd:pfam01131 301 EGEELKVTQVEVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVE-ALEKF 379
|
410 420 430
....*....|....*....|....*....|.
gi 654961648 518 PEILDVEFTAKMENDLDEVEDGNVQWVRVID 548
Cdd:pfam01131 380 PDLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
130-556 |
1.97e-162 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 472.09 E-value: 1.97e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 130 MDLVDAQQARRILDRLVGYNISPLLWKKV--KKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKatfqkgndqfegq 207
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLrrKGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 208 lieyqgkkvelsneddvtnivkqldgnEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGidl 287
Cdd:cd00186 68 ---------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA--- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 288 gkegtvGLITYMRTDSTRISETAQTEARDYITNAYGNQFVATEKRKE----KKNSNAQDAHEAIRPTSALRKPgEVKEFL 363
Cdd:cd00186 118 ------GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGrrnpKRGKKEQGAHEAIRPTKVAPTP-ELEANL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 364 SRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDDqveeKENLLPDLEEGEVAY 443
Cdd:cd00186 191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDD----EEEEPPPLKEGDELK 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 444 SKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDV 523
Cdd:cd00186 267 LEEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHFPELVDP 346
|
410 420 430
....*....|....*....|....*....|...
gi 654961648 524 EFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEK 556
Cdd:cd00186 347 EFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKK 379
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
242-509 |
3.85e-109 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 330.75 E-value: 3.85e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 242 TKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGidlgkegtvGLITYMRTDSTRISETAQTEARDYITNA 321
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEK---------GLITYPRTDSTRLSEEAVLEARNYIQKL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 322 YGNQFVA-----TEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEfLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLK 396
Cdd:smart00437 72 YGKEYLDlavvlLKPRKPRKGKKAQGAHEAIRPTKPIFTPELEKE-LSEDEFKLYELIWRRFLASQMPDAKYEETKVTIK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 397 NGDVTFRANGSKVKFPGFMKVYVEgnddQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGR 476
Cdd:smart00437 151 IGGEKFKAKGKTLLFDGWLKVYPE----EKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGR 226
|
250 260 270
....*....|....*....|....*....|...
gi 654961648 477 PSTYAPTLDTIQKRGYVALDNKRFVPTELGEIV 509
Cdd:smart00437 227 PSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| RNA_POL_M_15KD |
pfam02150 |
RNA polymerases M/15 Kd subunit; |
660-691 |
2.62e-05 |
|
RNA polymerases M/15 Kd subunit;
Pssm-ID: 280336 Cd Length: 36 Bit Score: 41.69 E-value: 2.62e-05
10 20 30
....*....|....*....|....*....|..
gi 654961648 660 CPKCENLLVEKKQKKGTQVVCTSCDYKEEAQQ 691
Cdd:pfam02150 4 CPKCGNLLLPTEDKLGSNFECRQCGYEEPADQ 35
|
|
| RPOL9 |
smart00661 |
RNA polymerase subunit 9; |
660-691 |
4.61e-04 |
|
RNA polymerase subunit 9;
Pssm-ID: 197822 Cd Length: 52 Bit Score: 38.52 E-value: 4.61e-04
10 20 30
....*....|....*....|....*....|..
gi 654961648 660 CPKCENLLVEKKQKKGTQVVCTSCDYKEEAQQ 691
Cdd:smart00661 3 CPKCGNMLYPREGKEKRRFVCRKCGYEEPAEQ 34
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-647 |
0e+00 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 975.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 1 MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLA 80
Cdd:PRK06599 1 MAKKLVIVESPAKAKTIKKYLGKDYKVLASFGHVRDLPKKKGGVDPDNDFAPKYEIIEGKEKVVDALKKAAKKADAVYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 81 ADPDREGEAIAWHLAHSLDVDIASDC---RVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKK 157
Cdd:PRK06599 81 TDPDREGEAIAWHIAEVLKEAKLKDKnvkRVVFNEITKKAVQEAIENPRDIDMDLVDAQQARRALDYLVGFKLSPLLWKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 158 VKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQ-FEGQLIEYQGKKVE---LSNEDDVTNIVKQLDG 233
Cdd:PRK06599 161 VRRGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGEpFTAKLVEVNGKKLEkfsITNEEQAKALVKALEG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 234 NEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGkEGTVGLITYMRTDSTRISETAQTE 313
Cdd:PRK06599 241 QAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEGIDLG-EGTVGLITYMRTDSVRLSNEALDE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 314 ARDYITNAYGNQFVATEKRKEKKNS-NAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMA 392
Cdd:PRK06599 320 ARKYITKKYGKEYLPAKPRVYKKKSkNAQEAHEAIRPTSINRTPESLKPYLTPDQFKLYELIWKRTVASQMAPAILDQTS 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 393 VDLK--NGDVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLE 470
Cdd:PRK06599 400 VDIAseNGKYVFRATGSVILFPGFLKVYGESKDDEEEDDEKLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKLE 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 471 ELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEF 550
Cdd:PRK06599 480 EYGIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIVNDFLVEHFPKYVDYDFTAGLEDELDEIAEGKKDWKPVLREF 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 551 YSDFEKRLEHAEKEMREVEIKDEPAGEDCEEC-GSPMVYKMGRYGKFMACSNFPDCRNTKPI-----------VKEIGVK 618
Cdd:PRK06599 560 WEPFISNLEKVEEDVRTEKVTQEETDETCPKCgGGPLVLKLGKNGKFLGCSGYPECKYTKNItrdedepieeeEIVEEEK 639
|
650 660 670
....*....|....*....|....*....|.
gi 654961648 619 CPKCEEGNIVerksKKKRT--FYGCDRFPGC 647
Cdd:PRK06599 640 CPKCGGPLVL----KKGRYgkFLACSGYPEC 666
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
5-612 |
0e+00 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 917.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLAADPD 84
Cdd:TIGR01051 1 LVIVESPAKAKTIKKYLGDEYEVEASMGHIRDLPKSRLGVDIEKDFEPEYVVSKGKKKVVKELKTLAKKADEVYLATDPD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 85 REGEAIAWHLAHSLDVDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLSA 164
Cdd:TIGR01051 81 REGEAIAWHLAEVLKPKDPVYKRIVFNEITKKAIRAALKNPREIDMNLVNAQQARRILDRLVGYTLSPLLWKKVAKGLSA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 165 GRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKV---ELSNEDDVTNIVKQLDGNEFSISKV 241
Cdd:TIGR01051 161 GRVQSVALRLIVDREREIKRFVPEEYWTIDATFQKGEETFEALLTEVNGKKLkagSDLDEAEATALKEQLKGEELVVEEI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 242 TKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGkEGTVGLITYMRTDSTRISETAQTEARDYITNA 321
Cdd:TIGR01051 241 EKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGVSTG-DGTIGLITYMRTDSTRLSNQAVNEARNLIDKN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 322 YGNQFVATE-KRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKN--G 398
Cdd:TIGR01051 320 YGKEYLGPKpKRYKSKEKNAQEAHEAIRPTSVFRTPEELKDYLKRDEFRLYELIWKRFVASQMADARYDSTSVRLTNedG 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 399 DVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPS 478
Cdd:TIGR01051 400 EYVFKATGRKLIFDGYYKVYVEGSDDPLEEKDRILPPLKEGDAVKLVEVKPNQHFTQPPARYTEASLVKELEELGIGRPS 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 479 TYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEKRL 558
Cdd:TIGR01051 480 TYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKMEKDLDEIAEGKAEWKPVLKNFYTGFSSKV 559
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 654961648 559 ehaEKEMREVEIKDEPAGEDCEECGSPMVYKMGRYGKFMACSNFPDCRNTKPIV 612
Cdd:TIGR01051 560 ---KKLRNMRIIVDFKTSQDCPLCGRPMVVKLGKYGPFLACSNFPECKYTKSIV 610
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
4-559 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 872.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 4 YLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLAADP 83
Cdd:COG0550 2 KLVIVESPAKAKTIAKYLGKDYVVTASVGHLRDLPKPELDVDVENDFEPKYEVIPGKKKQVKELKKLAKKADEVILATDP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 84 DREGEAIAWHLAHSLDVDiASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKGLS 163
Cdd:COG0550 82 DREGEAIAWHLLELLGDK-KPVKRVVFNEITKKAIKEAFKNPRDIDMNLVDAQQARRILDRLVGYNLSPLLWKKVKRGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 164 AGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKveLSNEDDVTNIVKQLDGNEFSISKVTK 243
Cdd:COG0550 161 AGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGGEFTAKLVKIDGKK--ILDEEEAEAILAALKGKTFTVTSVEK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 244 RERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEgidlgkegtVGLITYMRTDSTRISETAQTEARDYITNAYG 323
Cdd:COG0550 239 KPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYE---------VGLITYMRTDSVRLSEDAVAAAREYIEALYG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 324 NQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEvkefLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFR 403
Cdd:COG0550 310 KEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPES----LSGDEFKLYDLIWKRFLASQMPPAEYETTTVTIEVGGEEFR 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 404 ANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPT 483
Cdd:COG0550 386 ASGKVIKFPGFLKVYGEGKDDEEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTEASLVKAMEELGIGRPSTYASI 465
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654961648 484 LDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEKRLE 559
Cdd:COG0550 466 IETLQDRGYVEREGKRLVPTELGFIVIDLLEEHFPDLVDYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKELVE 541
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
5-614 |
0e+00 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 859.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKS--------------QMGIDIEQDYNPKYITIRGKGPVLKELKTA 70
Cdd:PRK07561 4 LVIVESPAKAKTINKYLGSDYVVKASVGHIRDLPTSassvpakekgalwaRMGVDPDHDFEALYEVLPGKEKVVSELKKA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 71 AKKAKKIYLAADPDREGEAIAWHLAHSL---DVDIAsdcRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVG 147
Cdd:PRK07561 84 AKDADELYLATDPDREGEAIAWHLLEVLggdDVPVK---RVVFNEITKNAIQEAFENPRELDINLVNAQQARRFLDRLVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 148 YNISPLLWKKVKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQK-GNDQFEGQLIEYQGKKVE---LSNEDD 223
Cdd:PRK07561 161 YMVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTpRGDAFEARLTHLDGKKFApvdLLNEAQ 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 224 VTNIVKQLDGNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEgidlgkegtVGLITYMRTDS 303
Cdd:PRK07561 241 AEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYE---------AGYITYMRTDS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 304 TRISETAQTEARDYITNAYGNQFVATEKRKEK-KNSNAQDAHEAIRPTSALRKPGEVKeFLSRDQYRLYKLVWERFVASQ 382
Cdd:PRK07561 312 TNLSQEAINAARGYIGDNYGKKYLPEKPRQYSsKAKNAQEAHEAIRPSDVFRTPDQLK-GLEGDAQRLYELIWKRFVASQ 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 383 MAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTE 462
Cdd:PRK07561 391 MAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDALDDEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSE 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 463 ARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQ 542
Cdd:PRK07561 471 ASLVKELEKLGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLEEFFPRLVDYDFTARMEEELDDIANGEAD 550
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654961648 543 WVRVIDEFYSDFEKRLEHAEKEMREVEIK---DEPAGEDCEECGSPMVYKMGRYGKFMACSNF---PDCRNTKPIVKE 614
Cdd:PRK07561 551 WKPVLDDFYKDFSQQLEKAEELREEGGMRpnqMVITDRDCPTCGRGMGIRTGKTGVFLGCSGYalkERCKTTRNLTPE 628
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-598 |
0e+00 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 667.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 1 MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLA 80
Cdd:PRK08780 1 MSKHLVIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPENGFAMRYDLIDKNEKHVEAIAKAAKSADDLYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 81 ADPDREGEAIAWHLAHSLD----VDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWK 156
Cdd:PRK08780 81 TDPDREGEAISWHLAEILKerglLKDKPMQRVVFTEITPRAIKEAMAKPRDIASDLVDAQQARRALDYLVGFNLSPLLWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 157 KVKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVE---LSNEDDVTNIVKQLD- 232
Cdd:PRK08780 161 KIQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPSQPFNAKLIKLDGQKFEqftITDGDTAEAARLRIQq 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 233 --GNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISETA 310
Cdd:PRK08780 241 aaQGTLHVTDVESKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQKLYEGVDLGDEGSVGLITYMRTDSVNLSQDA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 311 QTEARDYITNAYG-NQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMD 389
Cdd:PRK08780 321 LAEIRDVIARDYGtASLPDQPNTYKTKSKNAQEAHEAVRPTSALRTPAQVARFLSDDQRRLYELIWKRAVACQMIPATLN 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 390 TMAVDLKNGDV-TFRANGSKVKFPGFMKVYVEGNDD---QVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARL 465
Cdd:PRK08780 401 TVSVDLAAGSEhVFRATGSTVVVPGFLAVYEEGKDDksaEDEDEGRKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 466 VKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVR 545
Cdd:PRK08780 481 VKALEEYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLTGHFTRYVDYDFTARLEDDLDAVSRGEKEWIP 560
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....
gi 654961648 546 VIDEFYSDFEKRLEHAEKEM-REVEIKDEPAGEDcEECGSPMVYKMGRYGKFMA 598
Cdd:PRK08780 561 LMEKFWGPFKELVEEKKDSVdRTEAGQVRELGTD-PKSGKPVSVRIGRFGPMVQ 613
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-682 |
0e+00 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 641.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 1 MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLA 80
Cdd:PRK06319 1 MKKSLIIVESPAKIKTLQKLLGEGFIFASSLGHIVDLPAKEFGIDIENDFEPDYQILPDKEEVINKICKLAKKCDVVYLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 81 ADPDREGEAIAWHLAHSLDVDIASDcRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKK 160
Cdd:PRK06319 81 PDPDREGEAIAWHIANQLPKNTKIQ-RISFNAITKGAVTEALKHPREIDMALVNAQQARRLLDRIVGYKISPILSRKLQR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 161 --GLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQ--FEGQLIEYQGKKVE--------------LSNED 222
Cdd:PRK06319 160 rsGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKDPKTQktFWAHLYSVDGKKWEkeipegktedevllINSKE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 223 DVTNIVKQLDGNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTD 302
Cdd:PRK06319 240 KADHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSRTMNIAQTLYEGVDLDSEGATGLITYMRTD 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 303 STRISETAQTEARDYITNAYGNQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQ 382
Cdd:PRK06319 320 SVRTDPEALKQVRKYIEGTFGKEFLPSSPNVYTTKKMAQDAHEAIRPTDITLTPEKLRSKLTEDQYKLYSLIWKRFVASQ 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 383 MAPAIMDTMAVDLK-NGDVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENL-LPDLEEGEVAYSKDIDEKQHFTQPPPRY 460
Cdd:PRK06319 400 MIPAIYDTLAIRITtNKGIDLRATGSLLKFKGFLAVYEEKRDDEGDEEENIhLPKLHEQDVLTKEELSAEQAFTKPLPRF 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 461 TEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGN 540
Cdd:PRK06319 480 TEASLVKELEKSGIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQFLETNFPRIMDIGFTALMEDELELIADNK 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 541 VQWVRVIDEFYSDFEKRLEHAEKE------MREVEI-------------------------------------------- 570
Cdd:PRK06319 560 KPWKLLLQEFWELFLPVVVTAEKEafipriVTEIDCpkchkgklvkiwaknryfygcseypecdyktseeeltfnkedya 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 571 KDEPAGEDCEECGSPMVYKMGRYGKFMACSNFPDCRNTKPIVK--------EIGVKCPKCE-EGNIVERKSKKKRTFYGC 641
Cdd:PRK06319 640 EDTPWDSPCPLCGGEMKVRHGRFGTFLGCENYPECRGIINIHKkgeegiepEETVPCPAIGcTGHIVKRRSRFNKMFYSC 719
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 654961648 642 DRFPGCDFV--SWDKPIArKCPKCENLLVEKKQKKGTQVVCTS 682
Cdd:PRK06319 720 SEYPACSVIgnSIDAVIT-KYAGTPKTPYEKKTKAKKKSASTK 761
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
127-548 |
2.20e-169 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 490.99 E-value: 2.20e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 127 AINMDLVDAQQARRILDRLVGYNISPLLWKKVK--KGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQF 204
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLKgnKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 205 EGQLIeyqgKKVELSNEDDVTNIVKQLDGNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEg 284
Cdd:pfam01131 81 ANAKW----KRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 285 idlgkegTVGLITYMRTDSTRISETAQ-TEARDYITNAYGNQF-----VATEKRKEKKNSNAQ-DAHEAIRPTsalrKPG 357
Cdd:pfam01131 156 -------KHGLITYPRTDSTYLSDDATlKAILEYLTKNYGKYLpyaprLLKKTKGKLTVGNAKvTAHEAIRPT----GDI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 358 EVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDdqveEKENLLPDLE 437
Cdd:pfam01131 225 PVLPELSDDERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKK----EDEEELPELK 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 438 EGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLElVLEFF 517
Cdd:pfam01131 301 EGEELKVTQVEVEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVE-ALEKF 379
|
410 420 430
....*....|....*....|....*....|.
gi 654961648 518 PEILDVEFTAKMENDLDEVEDGNVQWVRVID 548
Cdd:pfam01131 380 PDLVDPELTAELEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
130-556 |
1.97e-162 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 472.09 E-value: 1.97e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 130 MDLVDAQQARRILDRLVGYNISPLLWKKV--KKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKatfqkgndqfegq 207
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLrrKGVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIK------------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 208 lieyqgkkvelsneddvtnivkqldgnEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGidl 287
Cdd:cd00186 68 ---------------------------EAVVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEA--- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 288 gkegtvGLITYMRTDSTRISETAQTEARDYITNAYGNQFVATEKRKE----KKNSNAQDAHEAIRPTSALRKPgEVKEFL 363
Cdd:cd00186 118 ------GLITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLGrrnpKRGKKEQGAHEAIRPTKVAPTP-ELEANL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 364 SRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDDqveeKENLLPDLEEGEVAY 443
Cdd:cd00186 191 SEDEFKLYELIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDD----EEEEPPPLKEGDELK 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 444 SKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDV 523
Cdd:cd00186 267 LEEVELEEKETQPPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHFPELVDP 346
|
410 420 430
....*....|....*....|....*....|...
gi 654961648 524 EFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEK 556
Cdd:cd00186 347 EFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKK 379
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
1-686 |
8.17e-111 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 350.32 E-value: 8.17e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 1 MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLA 80
Cdd:COG0551 9 LAAAKEAVKLVKKKKKKKKEGKKKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 81 ADPDREGEAIAWHLAHSLDVDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKK 160
Cdd:COG0551 89 LAAADDDAIEAAAAADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAASRALRLLLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 161 GLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVELSNEDDVTNIVKQLDGNEFSISK 240
Cdd:COG0551 169 LAAGRLRLLSAVAAGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKKKKKKKDKEEETKAIKKKKKAAEAV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 241 VTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISETAQTEARDYITN 320
Cdd:COG0551 249 LAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGELLYTGGYIRYTRTPKSSEADALAALEAL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 321 AYGNQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDV 400
Cdd:COG0551 329 KKIAEEPPDERAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRKLLLELLVRRRFAAAADLAKVEELTKVEE 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 401 TFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTY 480
Cdd:COG0551 409 ADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLEEEGGGGRGTT 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 481 APTLDTIQKRGY-VALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFYSDFEKRLE 559
Cdd:COG0551 489 ATIIILILKRRYvVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLE 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 560 HAEKEMREV-EIKDEPAGEDCEECGSPMVYKMGRYGKFMACSNFPDCRNTKPIVK--EIGVKCPKCeEGNIVERKSKKKR 636
Cdd:COG0551 569 IAEEEGEEElSEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNYPECKYTKPLPKpeVTGVKCPKC-GKKLVLRKSKKGK 647
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 654961648 637 TFYGCDRFPGCDFVSWDKPIARKCPKCENLLVEKKQKKGtqvvCTS--CDYK 686
Cdd:COG0551 648 VFYGCSNYPKCKFTEWDKPVKEPCPKCGSPLVEKKTKKG----CANklCGYE 695
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
242-509 |
3.85e-109 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 330.75 E-value: 3.85e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 242 TKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGidlgkegtvGLITYMRTDSTRISETAQTEARDYITNA 321
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEK---------GLITYPRTDSTRLSEEAVLEARNYIQKL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 322 YGNQFVA-----TEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEfLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLK 396
Cdd:smart00437 72 YGKEYLDlavvlLKPRKPRKGKKAQGAHEAIRPTKPIFTPELEKE-LSEDEFKLYELIWRRFLASQMPDAKYEETKVTIK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 397 NGDVTFRANGSKVKFPGFMKVYVEgnddQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGR 476
Cdd:smart00437 151 IGGEKFKAKGKTLLFDGWLKVYPE----EKKEEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGR 226
|
250 260 270
....*....|....*....|....*....|...
gi 654961648 477 PSTYAPTLDTIQKRGYVALDNKRFVPTELGEIV 509
Cdd:smart00437 227 PSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
82-687 |
3.97e-99 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 322.72 E-value: 3.97e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 82 DPDREGEAI---AWHLA-HSLDVDIAsdcRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKK 157
Cdd:PRK07219 106 DYDREGELIgkeAYHILrEVCQVPVK---RARFSSLTKKEIRKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSLS 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 158 VK-----KGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKgNDQFEGQLIEYQGKKVELSNEDDVTNIVKQLD 232
Cdd:PRK07219 183 VRqlgrwDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWKIEALLDK-EAQYFYRDLIGGHEAEKFWDEEEAEEIYEKLK 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 233 G-NEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGidlgkegtvGLITYMRTDSTRISETAQ 311
Cdd:PRK07219 262 GaKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPKRAMEIAEKLYTA---------GYISYPRTDNTVYPDDLD 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 312 TE------ARDYITNAYGNQFVATEKRKEKKNSNAQDAHEAIRPTSALrKPGEvkefLSRDQYRLYKLVWERFVASQMAP 385
Cdd:PRK07219 333 PKellkklSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPVDVP-KREE----LSDDEWKVYELIVRRFLATLADP 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 386 AIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDDqveekENLLPDLEEGEVAYSKDI--DEKQhfTQPPPRYTEA 463
Cdd:PRK07219 408 AEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKFD-----EKELPDLEEGEKLKVNKIeiEAKE--TQPPKRYTQS 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 464 RLVKTLEELGIGRPSTYAPTLDTIQKRGYVaLDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQW 543
Cdd:PRK07219 481 SLIKEMEKRGLGTKATRHDIIEKLYKRGYV-IEGDPPRPTDLGIAVIEALEKYAPEIVSEEMTAQLEADMQAIEDGKKKK 559
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 544 VRVIDE-------FYSDFEKRLEHAEKEMREvEIKDEPAGED----CEECGSPMV---YKMGRYgkFMACSNFPDCRNTK 609
Cdd:PRK07219 560 EDVTEEsremlkeILSELKEKRKEIGDHLAG-SLKAENRSLKtigkCPECGGDLIiirTDKGSR--FVGCSGYPDCRNTF 636
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 610 PIVK--EIGV---KCPKCEEgNIVERKSKKKRTFYGCdrfPGCDFVSWDKPIAR---KCPKCENLLVEKKQKKGTQVVCT 681
Cdd:PRK07219 637 PLPStgRIKVldeVCEKCGL-PVIKILRGKQTFVVGC---PDCEAEKEEEDPDEvigPCPKCGGELAIKQLKYGSFLGCT 712
|
....*....
gi 654961648 682 S---CDYKE 687
Cdd:PRK07219 713 NypkCKYTL 721
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
5-551 |
4.50e-92 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 310.75 E-value: 4.50e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKK----------YKVK---------ASMGHVRDL-----PKSQMGI-DIEQDYNPKYITI-- 57
Cdd:COG1110 632 LVIVESPNKARTIASFFGKPsrrrigglrvYEVSigdylllitASGGHVFDLvteayARGFYGVlVENGRFIPVYDTIkr 711
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 58 -----------------------RGKGPVLKELKTAAKKAKKIYLAADPDREGEAIAWHLAHSLDVDIASDCRVVFNEIT 114
Cdd:COG1110 712 cldcgeqftdevevcprcgspniVDSLEIVEALRELATEVDEVLIGTDPDTEGEKIGWDVYNLLRPYAKNIKRIEFHEVT 791
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 115 KEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKG-LSAGRVQSIAVRLIIDREKEIAKfipEEYWTV 193
Cdd:COG1110 792 RKAILEALKNPREIDENLVEAQIVRRIEDRWIGFTLSQKLWKVFGNRnLSAGRVQTPVLGWIIERYEESRK---SKKYLI 868
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 194 KATFQkgndqfegqlieyqGKKVELSNEDDVT--NIVKQLDGN-EFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFR 270
Cdd:COG1110 869 ILTLE--------------NGRLELSIEDLKEaeEVRKALEKEvKVKVKKVEEEEEELNPLPPYTTDTLLRDASRRLGLS 934
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 271 AKKTMMIAQQLYEgidlgkegtVGLITYMRTDSTRISETAQTEARDYITNAYGNQFVATEKRKEkknsnaQDAHEAIRPT 350
Cdd:COG1110 935 AEETMRLAQDLFE---------SGLITYHRTDSTRVSDAGIAVAKEYISERFGEEYFKPRRWGE------GGAHEAIRPT 999
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 351 SALRKPG----------EVKEFLSRDQYRLYKLVWERFVASQMAPAIMD--TMAVDLKNGDVTFRANG-SKVKFPGFMKV 417
Cdd:COG1110 1000 RPLDAEDlrrlieegviELPIPLTRRHLRLYDLIFRRFMASQMRPAKVEkvKLRVSLELPGGEIEEERiVEIIEDGFLLI 1079
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 418 YvegnddqveEKENLLPDLEEGEVAYSKDIDEKQHFTQPpprYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDN 497
Cdd:COG1110 1080 Y---------PPIKVEPELKEGEYKVTEVKIRKVPKVPL---YTQGDLVREMKERGIGRPSTYAKIVETLLRRGYVVESK 1147
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 654961648 498 KR--FVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFY 551
Cdd:COG1110 1148 KGkkLVPTKLGIEVYNYLSENFPDLVSEERTRELEEKMDEIEEGEADYQDVLEELY 1203
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
22-605 |
2.23e-89 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 291.73 E-value: 2.23e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 22 GKKYKVKASMGHVRDL-PKSQMG---IDIEqdYNPKYITIRGKGPV---LKELKTAAKKAKKIYLAADPDREGEAIAWH- 93
Cdd:TIGR01057 37 GKKIIVASAVGHLFGLhPKSRGGypvFDIE--WVPIFEFDKGKGYVskyIKALSKLAKGADEYINACDYDIEGEVIGFKa 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 94 LAHSLDVDIASdcRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKKG------LSAGRV 167
Cdd:TIGR01057 115 LKYFCGVERAK--RMKFSTLTKQDIRRAYANPEEIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAagrwviLSAGRV 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 168 QSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGqliEYQGKKVElsNEDDVTNIVKQLDGNEF-SISKVTKRER 246
Cdd:TIGR01057 193 QGPTLAFLVEREREINLFVPKPYWVIKATLEKGGGVFDA---RPEKWKIW--SEEEAKSIKEELKKSPWaAVEEVRSERS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 247 KRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGidlgkegtvGLITYMRTDSTRISETAQTEArDYITNAYGNQF 326
Cdd:TIGR01057 268 ILKPPPPFDLGTLQREAYRIFGFSPKKTQSIAQELYEE---------ALISYPRTSSQKLPPSINYRA-ILDNLAKGPLY 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 327 -VATEKRKEKKN------SNAQDAHEAIRPTSALRKPGevkefLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGD 399
Cdd:TIGR01057 338 rEAAERLLETGVlkpvegKKEDPAHPAIHPTGEIPSQE-----LSKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQ 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 400 VTFRANGSKVKFPGFMKVYVEGNDDQVEekenlLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPST 479
Cdd:TIGR01057 413 EKFRLSGLRVVKLGWLEYYHYSKFEEKE-----LPPLDRGDKIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKAT 487
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 480 YAPTLDTIQKRGYVAlDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDE-------FYS 552
Cdd:TIGR01057 488 RARIIETLYKRGYIE-GKKSIKVTPLGEAVIETLQRYCPEIISEELTRRFESKLEDIMSGRITKDEVIDEakkrlrkILE 566
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 654961648 553 DFEKRLEHAEKEMREVEIKDEPAGEdCEECGSPMVYKMGRYGKFMACSNFPDC 605
Cdd:TIGR01057 567 EFKKRLDDIGIELGKSLGSVEVVGK-CPKCGGKLVSKYAKKGRFVGCSNYPEC 618
|
|
| rgy |
TIGR01054 |
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial ... |
5-551 |
4.07e-86 |
|
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273418 [Multi-domain] Cd Length: 1171 Bit Score: 293.66 E-value: 4.07e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYK-------------------VKASMGHVRDL--PKSQMGIDIEQ-DYNPKYITI----- 57
Cdd:TIGR01054 604 LLVVESPNKARTIARFFGKPSVrkiggsvvyevpvgdlilmITASGGHVFDLvtDKGFHGVLVENgRYVPVYTSIkrcrd 683
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 58 --------------------RGKGPVLKELKTAAKKAKKIYLAADPDREGEAIAWHLAHSLDVDIASDCRVVFNEITKEA 117
Cdd:TIGR01054 684 cgyqftedrescpkcgseniEDSKSIIEILRELAHEVDEVFIGTDPDTEGEKIGWDLALLLSPYNPNVKRAEFHEVTRRA 763
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 118 IKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKV-KKGLSAGRVQSIAVRLIIDREKEIAKFIPEeywtvkat 196
Cdd:TIGR01054 764 ILEALESPRSVDENLVKAQVVRRIEDRWIGFTLSQKLWEAFnKRWLSAGRVQTPVLGWIIDRYRESREKRGY-------- 835
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 197 fqkgndqfegQLIEYQGKKVELSNEDDVTNIVKQLDGNE--FSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKT 274
Cdd:TIGR01054 836 ----------LLIFALESDFRLGLEHDNRLEAKEFEKDLtwLDVEDIAEREEERNPLPPYTTDTMLEDANRKLGLSVKET 905
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 275 MMIAQQLYEgidlgkegtVGLITYMRTDSTRISETAQTEARDYITNAYGNQFVATEKRKEkknsnaQDAHEAIRPTsalr 354
Cdd:TIGR01054 906 MQIAQELFE---------NGLITYHRTDSTRVSDVGMRVAKEYLASRLGGEYFYPREWGE------GGAHECIRPT---- 966
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 355 KPGEVKEF-------------LSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDVT-FRANGSKVKFPGFMKVYve 420
Cdd:TIGR01054 967 RPLDVDDLqrlilegvielegLTREHLRLYDLIFRRFMASQMRPAKVDTKEITLKADGKEaEEEGIVEIVERGFELVY-- 1044
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 421 gnddqveeKENLLPDLEEGEVAYSKDIDEKQHFTQPPprYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRF 500
Cdd:TIGR01054 1045 --------PLWRKNELEKGSTFIVKDKELRSVPKVYP--YTQGEIVQEMKERGIGRPSTYATIVEKLLRRGYVVESKGFL 1114
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|.
gi 654961648 501 VPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWVRVIDEFY 551
Cdd:TIGR01054 1115 IPTKLGIEVYNYLTNRYPKLVSEDRTRELEEAMDKIERGELDYLEVLESVY 1165
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
4-621 |
8.06e-84 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 278.03 E-value: 8.06e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 4 YLVIVESPAKAKTI-----ERYL---------------GKKYKVKASMGHVRDLPKSQMGIDI-EQDYNPKYITIRGKG- 61
Cdd:PRK05776 3 ILVIAEKPKAARKIaealsEKPIrcriygvpywivkrdGKKIVVAPAAGHLFGLHTKSKGFPVfDYEWKPLYEIDKGSKy 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 62 --PVLKELKTAAKKAKKIYLAADPDREGEAIAWhLAHSLDVDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQAR 139
Cdd:PRK05776 83 tkKYYELLSSLSKYADEFINACDYDIEGSVIGY-LIIKYLGDPKKAKRMKFSALTKSDIRRAFRNLETLDYEMINAGIAR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 140 RILDRLVGYNISPLLWKKVKKG------LSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEgqlIEYQG 213
Cdd:PRK05776 162 HELDWLWGINVSRALMSSVRDAsgkrviLSAGRVQSPTLKYVVEREIERNLFVPLPYFSVSIIIEKNGYEFT---LKYEN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 214 KKVElsNEDDVTNIVKQLDGNEF-SISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGidlgkegt 292
Cdd:PRK05776 239 KKFE--TKEEAKEILEEIKKTGYlKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAEDLYLD-------- 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 293 vGLITYMRTDSTRISET-----------AQTEARDYItnayGNQFVATEKRKEKKNSNAQD-AHEAIRPTsalrkpGEVK 360
Cdd:PRK05776 309 -GLISYPRTNSQKLPPTlnirnilkglsRSPQYRPLV----NLLLKETKGVLKPVQGPKDDpAHPAIYPT------GEPP 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 361 EFLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLKNGDV--TFRANGSKVKFPGFMKVYvegNDDQVEEKEnlLPDLEE 438
Cdd:PRK05776 378 KNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFplVFSASGQRIEERGWLKYY---PFHKFDEEE--LPLLKK 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 439 GEVAYSKDIDEKQHFTQPPPRYTEARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFP 518
Cdd:PRK05776 453 GERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGYLTSNGKYIEVTPLGFGVAEVLEKYFP 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 519 EILDVEFTAKMENDLDEVEDGNVQWVRVIDE-------FYSDFEKRLEHAEKEMREVEIKDEPAGEdCEECGSPMV---- 587
Cdd:PRK05776 533 DIVSVELTRDFEEKLEMIRTGKATREEVIEEaketlnkLLEEFKKNKDEIGEELAKALGLIKPVGK-CKICGREAYkdgl 611
|
650 660 670
....*....|....*....|....*....|....*.
gi 654961648 588 --YKMGRYGKFMACSNFPDCRNTKPIvKEIGVKCPK 621
Cdd:PRK05776 612 ckYHYEAKKRLVKAYEEWKERTGYDH-KEYLEKISK 646
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
82-654 |
9.45e-82 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 274.33 E-value: 9.45e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 82 DPDREGEAI---AWHLAHSLDVDIASDcRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYN----ISPLL 154
Cdd:PRK07220 106 DYDREGELIgveALNIIKKVNPDIKFD-RVRYSAITKKEIERAFSNPVEVDFNLADAGHSRQVIDLVWGAAltryISLAA 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 155 WKKVKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGndqfeGQLIEYQGKKVELSNEDDVTNIVKQLdGN 234
Cdd:PRK07220 185 GRLGKMFLSVGRVQSPTLALIVDREKEREAFVPTPYWEIYATLENN-----GETFVAQHSTRRFWEKEEADRVFEKL-GK 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 235 EFSISKVTKRERKRNAAPSFTTSSLQQeAARKLNFRAKKTMMIAQQLYegidlgkegTVGLITYMRTDSTRISET----- 309
Cdd:PRK07220 259 TAEVTEVEKGTKTDKPPTPFNTTEFIS-AANSIGFSAANAMRIAESLY---------TNGYISYPRTDNTVYPESldlre 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 310 -----AQTEARDYITNAYG-NQFVATEKRKEKKNsnaqdaHEAIRPTSALRKpGEVKEflsrDQYRLYKLVWERFVASQM 383
Cdd:PRK07220 329 qieifAEGPFGEYAQKLLEkGELVPTRGKKETTD------HPPIYPASLAKK-SELKE----DEWKVYELVVRRFFATFA 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 384 APAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGnddqvEEKENLLPDLEEGEV--AYSKDIDEKQhfTQPPPRYT 461
Cdd:PRK07220 398 GPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYN-----APEDRLLPELSEGEElkVKKKEMLDKE--TQPPGRYG 470
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 462 EARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNkrFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNV 541
Cdd:PRK07220 471 QGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHGNP--IQPTNTAFAVVDALEKYAPTITKPDMTSRLEEDMDKIAEGKI 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 542 QWVRVIDE-------FYSDFEKRLEHAEKEMREVEIKDEPAGEdCEECGSP-MVYKMGRYGKFMACSNFPDCRNTKPIVK 613
Cdd:PRK07220 549 KEDAVLEEsremleqVFDELDKNREKIRESLREGLREDKIIGK-CPLCGSDlMVRRSKRGSRFIGCEGYPECTFSLPLPK 627
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 654961648 614 --EIGVKCPKCEEGNIVERK---SKKKRTFYGCdrfPGCDFVSWDK 654
Cdd:PRK07220 628 sgQIIVTDKVCEAHGLNHIRiinGGKRPWDLGC---PQCNFIEWQK 670
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
82-622 |
9.69e-78 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 261.64 E-value: 9.69e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 82 DPDREGEAIA-WHLAHsldvdiasdCRVV-------FNEITKEAIKESFKHPRA----INmdLVDAQQARRILDRLVGYN 149
Cdd:PRK07726 101 DADREGELIArEILDY---------CGVRkpikrlwISSLTDKAIKRAFANLKPgketIP--LYYSALARSRADWLVGIN 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 150 ISPLLWKKVKKG-----LSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFqKGNDQFEGQLIEYQGKKVE---LSNE 221
Cdd:PRK07726 170 MTRAYTLLGRKAgyngvLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHL-TPGERFTAKWQPSEPYQDEegrLLDR 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 222 DDVTNIVKQLDGNEFSISKVTKrERKRNAAPS-FTTSSLQQEAARKLNFRAKKTMMIAQQLYEgidlgkegTVGLITYMR 300
Cdd:PRK07726 249 PLAEQVVARIQGQPAKVTEVET-KRKKEYAPLlYDLSELQIDANKRFGLSAKETLDIAQSLYE--------THKLITYPR 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 301 TDSTRISETAQTEARDYI-----TNAYGNQFVATEKRKEKK---NSNAQDAHEAIRPTsalRKPGEVkEFLSRDQYRLYK 372
Cdd:PRK07726 320 TDSRYLPEDMVATLPEVLnaiskVDPYLLLAPPVLDPSIRSrawNDKKVTAHHAIIPT---EQPPNL-SKLSEDERKVYD 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 373 LVWERFVASQMAPAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYveGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQH 452
Cdd:PRK07726 396 LIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALL--GKKEEDEEKEQPLPVLAKGDELKVEKGEVKEG 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 453 FTQPPPRYTEA----------------RLVKTLEEL-GIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVle 515
Cdd:PRK07726 474 QTQPPKRFTEGtllsameniarfvqdkELKKTLKETdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQLIDAL-- 551
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 516 ffPEIL-DVEFTAKMENDLDEVEDGNVQWvrviDEFYSDFEKRLEHAEKEMREVEIK---DEPAGEDCEECGSPMVYKMG 591
Cdd:PRK07726 552 --PEELtSPDMTAKWEQALDQISEGQLSY----QDFMQPLKQWLKQLVEQAKQSSEKykfDNLTGPKCPDCGKPMLKVKG 625
|
570 580 590
....*....|....*....|....*....|.
gi 654961648 592 RYGKFMACSNFPDCRnTKPIVKEIGVKCPKC 622
Cdd:PRK07726 626 KNGKMLVCQDRECGK-RKNVSKKTNARCPNC 655
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
1-614 |
9.29e-71 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 247.42 E-value: 9.29e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 1 MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQDYNPKYITIRGKGPVLKELKTAAKKAKKIYLA 80
Cdd:COG1754 3 AAVLVVVVVVVVKVPAAKKVLPKYAKKKKGVKAVLKKADVAKADDKVVDDDDKKDDVDDDKKKKKKLLKAAAKKKKALAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 81 ADPDREGEAIAWHLAHSLDVDIASDCRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKK 160
Cdd:COG1754 83 ALAADDEDEELLAADDELEEEKVIKLLLLELAVERVARAAAVRAAAAEAARLAALLRRRLVLRRLVRRLLVRLLLLRLVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 161 GLSAGRVQSIAVRL------------IIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVELSNEDDVTNIV 228
Cdd:COG1754 163 LLLRLLVARRAARRrrrrrrrrarrrELERRRERARAAEAEEAAAAAAAAADAGRAAAARDGKGGGKLAAGGAAAAAAAA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 229 KQLDGNEFSISKVTKRERKRNAAPSFTTSSLQQEAARKLNFRAKKTMMIAQQLYEGIDLGKEGTVGLITYMRTDSTRISE 308
Cdd:COG1754 243 AAAAAAAAALAEAAAAAAVREPPTPTTTTTAQAATTTTTRAAAARTTRSAQQAARRTRLGGEGTYTTTTTTTTTTSAAAA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 309 TAQTEARDYITNAYGNQFVATEKRKEKKNSNAQDAHEAIRPTSALRKPGEVKEFLSRDQYRLYKLVWERFVASQMAPAIM 388
Cdd:COG1754 323 AAAAAAAALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAAARRPPAARAALLSDDRLLLELLLLRRTAAAAAAAAAA 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 389 DTMAVDLKN----GDVTFRANGSKVKFPGFMKVYVEGNDDQVEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEAR 464
Cdd:COG1754 403 TATTTAAAAaagaGAVGTAAAGAVFFFGGFLLFAEEEDDDEEDDDDDDLPALEEGLPLLKEGVLADQHFTQPPPRYTEAP 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 465 LVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNVQWV 544
Cdd:COG1754 483 LVKRMEELGIGRPSTYASILSTLADRIYVRLDKRRLIPEDKGRLVTAFLFSFFRRYVEYDFTADLEEFLDDVSDGELDWK 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 545 RVIDEFYSDFeKRLEHAEKEMREVEIKDEPA--GE-D------CEECGSPMVYKMGRYGKFMACSN-------FPDCRNT 608
Cdd:COG1754 563 AVLRRFWRDF-SAAYDETGDLRISEVLDALEdlGEiDpreinsCPLGTGGLSLRVGRYGPFIECSNyeprrasIPECLAP 641
|
....*.
gi 654961648 609 KPIVKE 614
Cdd:COG1754 642 DELTPE 647
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
82-606 |
4.99e-57 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 208.93 E-value: 4.99e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 82 DPDREGEAI---AWHLAHSLDVDIASDcRVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKV 158
Cdd:PRK14973 105 DFDTEGELIgkeAYELVRAVNPKVPID-RARFSAITKEEIVTAFAEPTDLDFALAAAGEARQIIDLIWGASLTRFISLAA 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 159 KKG----LSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVELSNEddvtniVKQLDGN 234
Cdd:PRK14973 184 HRGgdniLSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLSLATEKDGEGIEARHTHGRFTDSAAAEA------AYDATKE 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 235 EFSISKVtKRERKRNAAPS-FTTSSLQQEAARkLNFRAKKTMMIAQQLYEGidlgkegtvGLITYMRTDST------RIS 307
Cdd:PRK14973 258 PLVVTEV-KEGHKVDRAPTpFDTTTFIVAASR-LGFSAANAMRIAEDLYMN---------GYISYPRTDNTiypkslDLN 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 308 ETAQTEARDYITNAYGnqFVATEKRKE----KKNSNAqdaHEAIRPTSAlrkpgEVKEFLSRDQYRLYKLVWERFVASQM 383
Cdd:PRK14973 327 GVLATLAKGAFSKDVA--WVKDNRRPVptrgKKSSTD---HPPIHPTGV-----ATREELGDDRWKLYELVVRRFLATLS 396
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 384 APAIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYvegndDQVEEKENLLPDLEEGEV--AYSKDIDEKQhfTQPPPRYT 461
Cdd:PRK14973 397 PDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVY-----PYSEAKENILPAFALGEKlpILAVNLEEKE--TQPPARYS 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 462 EARLVKTLEELGIGRPSTYAPTLDTIQKRGYVALDNKRfvPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEVEDGNv 541
Cdd:PRK14973 470 QSRLIQRMEELGLGTKSTRHEVIGKLVSRKYIEGNPLR--PTLVGRAVTESLEEHAGTITEPDMTQTLEEHMQQIKERK- 546
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654961648 542 qwvRVIDEFYSDFEKRLEHA--EKEMREVEIKDEPAGEDCEE--------CGSPMVYKMGRYGKFMACSNFPDCR 606
Cdd:PRK14973 547 ---RTRDDVVTESRKMLHRAfdELEANEAVIGRDIMERTAEEltigpcpvCGKDLRIKHIGSSQFIGCSGYPDCT 618
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
82-606 |
4.48e-54 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 196.99 E-value: 4.48e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 82 DPDREGEAIAWHLAHSLDV-DIASDCRVVFNEITKEAIKESFKH--PRAINMDLVDAQQARRILDRLVGYNISPLLWKKV 158
Cdd:TIGR01056 104 DPDREGELIAREILDYLKVtDKVTIKRLWISSLVDSSIRKAFKNlrPKSETEGLYKSGVARARADWLVGINLTRAFTKLG 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 159 KKG-----LSAGRVQSIAVRLIIDREKEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVELSNEDDVTNIVKQLDG 233
Cdd:TIGR01056 184 REAgndgvLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVSATINKDEQEFTTEWQPYKDEEERELHEFLAENVVTDLTQ 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 234 NEFSISKVtKRERKRNAAPS-FTTSSLQQEAARKLNFRAKKTMMIAQQLYEgidlgkegTVGLITYMRTDSTRISETAQT 312
Cdd:TIGR01056 264 KPALVTDI-EKERKKTSAPLfYDLSALQEDANKRFGISAKRTLDIAQKLYE--------THKLITYPRTDSRYLPEDEKE 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 313 EARDYIT----NAYGNQFVA---TEKRKEKKNSNAQDAHEAIRPTSalrKPGeVKEFLSRDQYRLYKLVWERFVASQMAP 385
Cdd:TIGR01056 335 MLLEVLDalkvITPALLPIKkrdELTNNRLWNDKKIEDHHAIIPTG---NDF-NLSDLSEEERNVYKLIAQNYLMQFMPK 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 386 AIMDTMAVDLKNGDVTFRANGSKVKFPGFMKVYVEGNDDQvEEKENLLPDLEEGEVAYSKDIDEKQHFTQPPPRYTEAR- 464
Cdd:TIGR01056 411 EEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDE-ETEDTTLPAFQKGDELDVETLELLEKQTKPPARYTEGTl 489
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 465 ---------------LVKTLEEL-GIGRPSTYAPTLDTIQKRGYVALDNKRFVPTELGEIVLELVleffPEIL-DVEFTA 527
Cdd:TIGR01056 490 lsamtnpaafvqdkgLKKTLKETkGLGTEATRADIIENLFKRGFIQKKKNKIYITKNGKLLCLLL----PELLtKPDLTA 565
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 528 KMENDLDEVEDGNVQWvrviDEFYSDFEKRLEHAEKEMREV-EIKDEPAGEDCeECGSPMVYKMGRYGKFMACSNFPDCR 606
Cdd:TIGR01056 566 QWEQYLNGISAGEKDD----DDFINTINEMIKQTINEEKKNpETIQKVAKEPV-SCGGIAKCPAKDNGRLIDCKKFPECT 640
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
5-125 |
2.18e-51 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 173.90 E-value: 2.18e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGIDIEQD-YNPKYITIRGKGPVLKELKTAAKKAKKIYLAADP 83
Cdd:cd03363 3 LVIVESPAKAKTIKKYLGKEYEVLASVGHIRDLPKKGLGVDGEDDgFEPKYVVIPGKKKVVKELKKLAKKADEIYLATDP 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 654961648 84 DREGEAIAWHLAHSLDVDIaSDCRVVFNEITKEAIKESFKHP 125
Cdd:cd03363 83 DREGEAIAWHLAEVLKLKK-NVKRVVFNEITKEAIKEALKNP 123
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
82-536 |
1.75e-42 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 165.11 E-value: 1.75e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 82 DPDREGEAIAWH-------LAHSLDVDIAsdcRVVFNEITKEAIKESFK--HPRAINMDLVDAQQARRILDRLVGYNISP 152
Cdd:PTZ00407 133 DPDREGELIAVHalqtikrLYPKLKVPFS---RAYMHSITEDGIRKAMRerHVEACDYDLANAAETRHAMDRIFGFLGSS 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 153 LLWKKVKKGLSAGRVQSIAVRLIIDREKEIAKFIPEEYWT--VKAT--FQKGNDQFEGQLI----EYQGKKVELSNEDDV 224
Cdd:PTZ00407 210 VVRAANSQMRSIGRVQTPALILINEREDKIKAFLESNKSTfeVQAMcqFPSPHGTTFSQVVtitpDRKGGASHWATEAEA 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 225 TNIVKQ--LDG-NEFSISKVTKRERKRNAAPS-FTTSSLQQEAARKLNFRAKKTMMIAQQLYEgidlgkegtVGLITYMR 300
Cdd:PTZ00407 290 RRCLEQwkLNNcTGFSVPLEPKPQPSVVPPPQpFTMATAIAKANRQLKYSSEMVSGCLQDLFQ---------LGHITYPR 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 301 TDSTRISETAQTEARDYITNAYGNQFV------------------ATEKR--KEKKNS-----NAQDAHEAIRPTSALRK 355
Cdd:PTZ00407 361 TDSTRIDESALPDIYAAVKKEFGKEFLyrledrtvsaqegkgskkTGKKRstKQKKGAdtpvgNVEDAHEAIRPTNIDTT 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 356 PGEVKefLSRDQYRLYKLVWERFVASQMAPAIMDTMAVDLK----NGD-VTFRANGSKVKFPGFMKVY----------VE 420
Cdd:PTZ00407 441 GESLS--LSPPTRAVYDLVRRNTLAVFMIPMKTEKIVATVKftsgSGEkLEFELQGKRVVEPGWTRAFhkgdkgttgpAE 518
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 421 GNDDQVEEKEN---LLPDLEEGE------VAYSKDIDEKQHFTQ------------PPPRYTEARLVKTLEELGIGRPST 479
Cdd:PTZ00407 519 ETDEDITAVEEgapVVPSLSQEEfkaimnLRSQLGSGVQKGFFElrspqvrenrpvPPLPHSEGTLIEELKNNGVGRPST 598
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 654961648 480 YAPTLDTIQKRGYVALDNK-RFVPTELGEIVLELVLEFFPEILDVEFTAKMENDLDEV 536
Cdd:PTZ00407 599 YPMIVKTLLARGYIAVNPKgRCETTPVGRMLVETAKSTFPSIVDIGFTAAFEKKLDRI 656
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
107-192 |
3.58e-42 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 147.34 E-value: 3.58e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 107 RVVFNEITKEAIKESFKHPRAINMDLVDAQQARRILDRLVGYNISPLLWKKVKK-GLSAGRVQSIAVRLIIDREKEIAKF 185
Cdd:smart00436 3 RIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIKNF 82
|
....*..
gi 654961648 186 IPEEYWT 192
Cdd:smart00436 83 VPKPYWE 89
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
1-540 |
1.01e-35 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 144.42 E-value: 1.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 1 MSDYLVIVESPAKAKTIERYLGK-----------KYKVKASMGHVrdlpksqMGIDIEQDYNPKyitiRGK--------- 60
Cdd:PRK08173 1 MSKALIIAEKPSVANDIARALGGftkhdeyfesdEYVLSSAVGHL-------LEIAAPEEYEVK----RGKwsfahlpvi 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 61 ------GPV------LKELKTAAKKAKKIYLAA--DPDREGEAI----AWHLAHSLDVDiasdcRVVFNEITKEAIKESF 122
Cdd:PRK08173 70 pphfdlNPIaktesrLKVLTKLIKRKDVTRLINacDAGREGELIfrliAQHAKAKKPVK-----RLWLQSMTPQAIRDGF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 123 KHPRAIN--MDLVDAQQARRILDRLVGYNISpllwkkvkKGLSA-------------GRVQSIAVRLIIDREKEIAKFIP 187
Cdd:PRK08173 145 ANLRSDEdmQPLADAARCRSEADWLVGINGT--------RAMTAfnskgggfflttvGRVQTPTLSIVVEREEKIRRFVP 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 188 EEYWTVKATFQKGNDQFEGQLIEYQGKKVELSNEDDVTN---------IVKQLDGNEFSISKVTKRERkRNAAPSFTTSS 258
Cdd:PRK08173 217 RDYWEVRAEFVAAAGFYEGRWFDPKFKKDEFDPEKRASRlwseaaaeaIVAACRGKPGTVTEESKPST-QLSPLLFDLTS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 259 LQQEAARKLNFRAKKTMMIAQQLYEgidlgKEgtvGLITYMRTDSTRISE----------TAQTEARDYITNA---YGNQ 325
Cdd:PRK08173 296 LQREANGRFGFSAKNTLGLAQALYE-----KH---KVLTYPRTDSRALPEdylgtvkqtlEMLKESNNYLPHAkqiLDKG 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 326 FVATEKR--KEKKNSNaqdaHEAIRPTsalrkpGEVKEFLSRDQYRLYKLVWERFVASQMAPA-IMDTMAVDLKNGDvTF 402
Cdd:PRK08173 368 WVKPNKRifDNSKISD----HFAIIPT------LQAPKSLSEPEQKLYDLVVKRFLAVFFPAAeFLVTTRITEVAGH-HF 436
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 403 RANGSKVKFPGFMKVYveGNDDQVEEkENLLPdLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKTLE---------EL- 472
Cdd:PRK08173 437 KTEGKVLVNPGWLAVY--GKEAQGAD-ANLVP-VQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddELr 512
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654961648 473 ------GIGRPSTYAPTLDTIQKRGYVALDNKRFVPT----ELGEIVLELVLEffpEILDVEFTAKMENDLDEVEDGN 540
Cdd:PRK08173 513 eamaekGLGTPATRAAIIEGLLGEKYLVREGRELIPTakafQLMTLLRGLGVE---ELTSPELTGEWEYKLSQIERGK 587
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
107-594 |
9.27e-32 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 132.39 E-value: 9.27e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 107 RVVFNEITKEAIKESFKHPR--AINMDLVDAQQARRILDRLVGYNISPLL--WKKVKKGL---SAGRVQSIAVRLIIDRE 179
Cdd:PRK14724 137 RLWLQSMTPQAIRDGFDNLRsdAQMQGLASAARSRSEADWLVGINGTRAMtaFNSRDGGFfltTVGRVQTPTLSLVVERE 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 180 KEIAKFIPEEYWTVKATFQKGNDQFEGQLIEYQGKKVE---------LSNEDDVTNIVKQLDGNEFSISKVTKRERKrnA 250
Cdd:PRK14724 217 EKIRKFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKASddpearadrVWSEREARAIADAVRGKAATVTEESKPTTQ--A 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 251 APS-FTTSSLQQEAARKLNFRAKKTMMIAQQLYEgidlgkegTVGLITYMRTDSTRISETAQTEARD------------- 316
Cdd:PRK14724 295 SPLlFDLTSLQREANGKFGFSAKTTLALAQSLYE--------RHKALTYPRTDSRALPEDYLPVAKQtfemlatsgmrhl 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 317 --YITNAYGNQFVATEKRKeKKNSNAQDaHEAIRPTsaLRKPGEvkefLSRDQYRLYKLVWERFVASQMAPAIMDTMAVD 394
Cdd:PRK14724 367 apFAQQALDGNYVRPSKRI-FDNSKVSD-HFAIIPT--TQAPSG----LSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRI 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 395 LKNGDVTFRANGSKVKFPGFMKVYVEGNDDQVEEK------ENLLPdLEEGEVAYSKDIDEKQHFTQPPPRYTEARLVKT 468
Cdd:PRK14724 439 SQVVGHSFKTEGKVLVKPGWLAIYGKEAANEVEDAkdgdkgQPLVP-VKPGEMVRTEFAEAKGLKTKPPARYSEATLLGA 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 469 LE----------------ELGIGRPSTYAPTLDTIQKRGYVALDNKRFVPT----ELGEIVLELVLEffpEILDVEFTAK 528
Cdd:PRK14724 518 MEsagkqidddelreamqEKGLGTPATRAAIIEGLLTEKYMLREGRELIPTakafQLMTLLRGLGVE---ELSRAELTGE 594
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654961648 529 MENDLDEVEDGnvQWVRviDEFYSDFEKRLEHAEKEMREVEiKDEPAGE------DCEECGSPMVYKMGRYG 594
Cdd:PRK14724 595 WEYKLAQMEKG--QLSR--EAFMQQIAAMTEKLVKKAKEYD-RDTIPGDyatlstPCPNCGGVVKENYRRYA 661
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
5-125 |
1.25e-28 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 111.55 E-value: 1.25e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKK------------YKVKASMGHVRDLPKSQMGIDIEQDYN-------PKYITIRGKGPVLK 65
Cdd:cd01028 3 LIIAEKPSKAKTIAKILGKGskkkgfygegggYVVTASVGHLLELPFPEEYVDWDKDWPlelfpfePKYVVIPDKKKQLK 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 66 ELKTAAKKAKKIYLAADPDREGEAIAWHLAHSLDVDIASDCRVVFNEITKEAIKESFKHP 125
Cdd:cd01028 83 ALKKLAKKADEIVLATDPDREGELIAWEILEVLKCDNKPVKRAWFSEITPKAIREAFKNL 142
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
576-613 |
5.28e-16 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 71.91 E-value: 5.28e-16
10 20 30
....*....|....*....|....*....|....*...
gi 654961648 576 GEDCEECGSPMVYKMGRYGKFMACSNFPDCRNTKPIVK 613
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFVGCSNYPECRFTRPLKK 38
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
5-113 |
1.60e-13 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 66.61 E-value: 1.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYK-VKASMGHVRDLPKsqmgidieqdynpkyitiRGKGPVLKELKTAAKKAKKIYLAADP 83
Cdd:pfam01751 2 LIIVEGPSDAIALEKALGGGFQaVVAVLGHLLSLEK------------------GPKKKALKALKELALKAKEVILATDP 63
|
90 100 110
....*....|....*....|....*....|
gi 654961648 84 DREGEAIAWHLAHSLDVDIASDCRVVFNEI 113
Cdd:pfam01751 64 DREGEAIALKLLELKELLENAGGRVEFSEL 93
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
5-98 |
6.23e-12 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 61.51 E-value: 6.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYKVKASMGHVrdLPKSQMGIdIEQDYNPKYITIrgkgpvlkelktaakkakkiylAADPD 84
Cdd:smart00493 3 LIIVEGPADAIALEKAGGKRGNVVALGGHL--LSKEQIKL-LKKLAKKAEVIL----------------------ATDPD 57
|
90
....*....|....
gi 654961648 85 REGEAIAWHLAHSL 98
Cdd:smart00493 58 REGEAIAWELAELL 71
|
|
| TOPRIM_TopoIA_RevGyr |
cd03361 |
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA ... |
5-125 |
8.16e-12 |
|
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173781 [Multi-domain] Cd Length: 170 Bit Score: 64.26 E-value: 8.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 5 LVIVESPAKAKTIERYLGKKYK-------------------VKASMGHVRDLPKSQMGIDIEQD---YNPKYITIR---- 58
Cdd:cd03361 3 LMIVESPNKARTIANFFGRPSVrrlgglvvyevstgdgvlmITASGGHVYDLVTKEGGHGVVEDdgrYVPVYDSIKrcrd 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 59 ---------------------GKGPVLKELKTAAKKAKKIYLAADPDREGEAIAWHLAHSLDVDIASDCRVVFNEITKEA 117
Cdd:cd03361 83 cgyqftedsdkcprcgsenidDKLETLEALRELALEVDEVLIATDPDTEGEKIAWDVYLALRPYNKNIKRAEFHEVTRRA 162
|
....*...
gi 654961648 118 IKESFKHP 125
Cdd:cd03361 163 ILEALRNP 170
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
616-656 |
3.42e-09 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 52.65 E-value: 3.42e-09
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 654961648 616 GVKCPKCEeGNIVERKSKKKrTFYGCDRFPGCDFVSWDKPI 656
Cdd:pfam01396 1 GGKCPKCG-GDLVLKRGRFG-KFVGCSNYPECRFTRPLKKN 39
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
3-98 |
1.95e-06 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 46.27 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654961648 3 DYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQmgIDIEQDYNPKYITIRgkgpvlkelktaakkakkiylaaD 82
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGGYGGAVVALGGHALNKTREL--LKRLLGEAKEVIIAT-----------------------D 55
|
90
....*....|....*.
gi 654961648 83 PDREGEAIAWHLAHSL 98
Cdd:cd00188 56 ADREGEAIALRLLELL 71
|
|
| RNA_POL_M_15KD |
pfam02150 |
RNA polymerases M/15 Kd subunit; |
660-691 |
2.62e-05 |
|
RNA polymerases M/15 Kd subunit;
Pssm-ID: 280336 Cd Length: 36 Bit Score: 41.69 E-value: 2.62e-05
10 20 30
....*....|....*....|....*....|..
gi 654961648 660 CPKCENLLVEKKQKKGTQVVCTSCDYKEEAQQ 691
Cdd:pfam02150 4 CPKCGNLLLPTEDKLGSNFECRQCGYEEPADQ 35
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
4-125 |
1.05e-04 |
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TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 42.99 E-value: 1.05e-04
10 20 30 40 50 60 70 80
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gi 654961648 4 YLVIVESPAKAKTIERYLGKKYKVKASM------------------GHVrdlpksqMGIDIEQDYNP------------- 52
Cdd:cd03362 2 VLIIAEKPSVAKAIAKILGGGSKKKGKGryyefygegggyvvtwasGHL-------LELDFPEEYDPwdkvwpledplfp 74
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90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 654961648 53 ---KYITIRGKGPVLKELKTAAKKAKKIYLAADPDREGEAIAWH-LAHSLDVDIASDCRVVFNEITKEAIKESFKHP 125
Cdd:cd03362 75 apfKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREiLEYAKCVKRKPVKRAWFSSLTPKAIRRAFKNL 151
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| RPOL9 |
smart00661 |
RNA polymerase subunit 9; |
660-691 |
4.61e-04 |
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RNA polymerase subunit 9;
Pssm-ID: 197822 Cd Length: 52 Bit Score: 38.52 E-value: 4.61e-04
10 20 30
....*....|....*....|....*....|..
gi 654961648 660 CPKCENLLVEKKQKKGTQVVCTSCDYKEEAQQ 691
Cdd:smart00661 3 CPKCGNMLYPREGKEKRRFVCRKCGYEEPAEQ 34
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