|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06466 |
PRK06466 |
acetolactate synthase 3 large subunit; |
1-574 |
0e+00 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 180578 [Multi-domain] Cd Length: 574 Bit Score: 1235.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK06466 1 MELLSGAEMLVRALRDEGVEYIYGYPGGAVLHIYDALFKQDKVEHILVRHEQAATHMADGYARATGKTGVVLVTSGPGAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK06466 81 NAITGIATAYMDSIPMVVLSGQVPSTLIGEDAFQETDMVGISRPIVKHSFMVKHASEIPEIIKKAFYIAQSGRPGPVVVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKDMTNPAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK06466 161 IPKDMTNPAEKFEYEYPKKVKLRSYSPAVRGHSGQIRKAVEMLLAAKRPVIYSGGGVVLGNASALLTELAHLLNLPVTNT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK06466 241 LMGLGGFPGTDRQFLGMLGMHGTYEANMAMHHADVILAVGARFDDRVTNGPAKFCPNAKIIHIDIDPASISKTIKADIPI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKEIGEQPDKAALDAWWKQIDEWRGDGALFPYDKGDGNLIKPQQVIETLCEVTKGDAFVTSDVGQH 400
Cdd:PRK06466 321 VGPVESVLTEMLAILKEIGEKPDKEALAAWWKQIDEWRGRHGLFPYDKGDGGIIKPQQVVETLYEVTNGDAYVTSDVGQH 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 401 QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVL 480
Cdd:PRK06466 401 QMFAAQYYKFNKPNRWINSGGLGTMGFGLPAAMGVKLAFPDQDVACVTGEGSIQMNIQELSTCLQYGLPVKIINLNNGAL 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 481 GMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLVFIDIAVDRTEHVYPMQIKD 560
Cdd:PRK06466 481 GMVRQWQDMQYEGRHSHSYMESLPDFVKLAEAYGHVGIRITDLKDLKPKLEEAFAMKDRLVFIDIYVDRSEHVYPMQIAD 560
|
570
....*....|....
gi 655281819 561 GSMRDMWLSKTERT 574
Cdd:PRK06466 561 GSMRDMWLSKTERT 574
|
|
| PRK08979 |
PRK08979 |
acetolactate synthase 3 large subunit; |
1-574 |
0e+00 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 181602 [Multi-domain] Cd Length: 572 Bit Score: 963.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK08979 1 MEMLSGASMIVRSLIDEGVKHIFGYPGGSVLDIYDALHEKSGIEHILVRHEQAAVHMADGYARATGKVGVVLVTSGPGAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK08979 81 NTITGIATAYMDSIPMVVLSGQVPSNLIGNDAFQECDMIGISRPVVKHSFLVKDAEDIPEIIKKAFYIASTGRPGPVVID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKDMTNPAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK08979 161 LPKDCLNPAILHPYEYPESIKMRSYNPTTSGHKGQIKRGLQALLAAKKPVLYVGGGAIISGADKQILQLAEKLNLPVVST 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK08979 241 LMGLGAFPGTHKNSLGMLGMHGRYEANMAMHNADLIFGIGVRFDDRTTNNLEKYCPNATILHIDIDPSSISKTVRVDIPI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKEIGEQPDKAALDAWWKQIDEWRGDGALfPYDKGDGNlIKPQQVIETLCEVTKGDAFVTSDVGQH 400
Cdd:PRK08979 321 VGSADKVLDSMLALLDESGETNDEAAIASWWNEIEVWRSRNCL-AYDKSSER-IKPQQVIETLYKLTNGDAYVASDVGQH 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 401 QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVL 480
Cdd:PRK08979 399 QMFAALYYPFDKPRRWINSGGLGTMGFGLPAAMGVKFAMPDETVVCVTGDGSIQMNIQELSTALQYDIPVKIINLNNRFL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 481 GMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLVFIDIAVDRTEHVYPMQIKD 560
Cdd:PRK08979 479 GMVKQWQDMIYQGRHSHSYMDSVPDFAKIAEAYGHVGIRISDPDELESGLEKALAMKDRLVFVDINVDETEHVYPMQIRG 558
|
570
....*....|....
gi 655281819 561 GSMRDMWLSKTERT 574
Cdd:PRK08979 559 GAMNEMWLSKTERT 572
|
|
| PRK07979 |
PRK07979 |
acetolactate synthase 3 large subunit; |
1-574 |
0e+00 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 181185 [Multi-domain] Cd Length: 574 Bit Score: 896.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK07979 1 MEMLSGAEMVVRSLIDQGVKQVFGYPGGAVLDIYDALHTVGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK07979 81 NAITGIATAYMDSIPLVVLSGQVATSLIGYDAFQECDMVGISRPVVKHSFLVKQTEDIPQVLKKAFWLAASGRPGPVVVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKDMTNPAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK07979 161 LPKDILNPANKLPYVWPESVSMRSYNPTTQGHKGQIKRALQTLVAAKKPVVYVGGGAINAACHQQLKELVEKLNLPVVSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK07979 241 LMGLGAFPATHRQSLGMLGMHGTYEANMTMHNADVIFAVGVRFDDRTTNNLAKYCPNATVLHIDIDPTSISKTVTADIPI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKEIGEQPDKAALDAWWKQIDEWRGDGALfPYDKgDGNLIKPQQVIETLCEVTKGDAFVTSDVGQH 400
Cdd:PRK07979 321 VGDARQVLEQMLELLSQESAHQPLDEIRDWWQQIEQWRARQCL-KYDT-HSEKIKPQAVIETLWRLTKGDAYVTSDVGQH 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 401 QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVL 480
Cdd:PRK07979 399 QMFAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPEETVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNNRYL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 481 GMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFA--MKDRLVFIDIAVDRTEHVYPMQI 558
Cdd:PRK07979 479 GMVKQWQDMIYSGRHSQSYMQSLPDFVRLAEAYGHVGIQISHPDELESKLSEALEqvRNNRLVFVDVTVDGSEHVYPMQI 558
|
570
....*....|....*.
gi 655281819 559 KDGSMRDMWLSKTERT 574
Cdd:PRK07979 559 RGGGMDEMWLSKTERT 574
|
|
| PRK06882 |
PRK06882 |
acetolactate synthase 3 large subunit; |
1-574 |
0e+00 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 168717 [Multi-domain] Cd Length: 574 Bit Score: 893.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK06882 1 MKKLSGAEMVVQSLRDEGVEYVFGYPGGSVLDIYDAIHTLGGIEHVLVRHEQAAVHMADGYARSTGKVGCVLVTSGPGAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK06882 81 NAITGIATAYTDSVPLVILSGQVPSNLIGTDAFQECDMLGISRPVVKHSFIVKNAEDIPSTIKKAFYIASTGRPGPVVID 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKDMTNPAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK06882 161 IPKDMVNPANKFTYEYPEEVSLRSYNPTVQGHKGQIKKALKALLVAKKPVLFVGGGVITAECSEQLTQFAQKLNLPVTSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK06882 241 LMGLGAYPSTDKQFLGMLGMHGTYEANNAMHESDLILGIGVRFDDRTTNNLAKYCPNAKVIHIDIDPTSISKNVPAYIPI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKEIGEQPDKAALDAWWKQIDEWRGDGALfPYDKGDGnLIKPQQVIETLCEVTKGDAFVTSDVGQH 400
Cdd:PRK06882 321 VGSAKNVLEEFLSLLEEENLAKSQTDLTAWWQQINEWKAKKCL-EFDRTSD-VIKPQQVVEAIYRLTNGDAYVASDVGQH 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 401 QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVL 480
Cdd:PRK06882 399 QMFAALHYPFDKPRRWINSGGAGTMGFGLPAAIGVKFAHPEATVVCVTGDGSIQMNIQELSTAKQYDIPVVIVSLNNRFL 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 481 GMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLVFIDIAVDRTEHVYPMQIKD 560
Cdd:PRK06882 479 GMVKQWQDLIYSGRHSQVYMNSLPDFAKLAEAYGHVGIQIDTPDELEEKLTQAFSIKDKLVFVDVNVDETEHVYPMQIRG 558
|
570
....*....|....
gi 655281819 561 GSMRDMWLSKTERT 574
Cdd:PRK06882 559 GAMNEMILSKPEET 572
|
|
| acolac_lg |
TIGR00118 |
acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form ... |
4-570 |
0e+00 |
|
acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272915 [Multi-domain] Cd Length: 558 Bit Score: 879.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAI 83
Cdd:TIGR00118 1 MSGAEAIIESLKDEGVKTVFGYPGGAILPIYDALYNDSGIEHILVRHEQGAAHAADGYARASGKVGVVLVTSGPGATNLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 84 TGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPK 163
Cdd:TIGR00118 81 TGIATAYMDSIPMVVFTGQVPTSLIGSDAFQEADILGITMPITKHSFQVKSAEDIPRIIKEAFHIATTGRPGPVLVDLPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 164 DMTNPAekFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMG 243
Cdd:TIGR00118 161 DVTTAE--IEYPYPEKVNLPGYRPTVKGHPLQIKKAAELINLAKKPVILVGGGVIIAGASEELKELAERIQIPVTTTLMG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 244 LGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIVGP 323
Cdd:TIGR00118 239 LGSFPEDHPLSLGMLGMHGTKTANLAVHECDLIIAVGARFDDRVTGNLAKFAPNAKIIHIDIDPAEIGKNVRVDIPIVGD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 324 VESVLSEMLTILKEIGEQPDKaaldAWWKQIDEWRGDGAL-FPYDKGDgnlIKPQQVIETLCEVTKGDAFVTSDVGQHQM 402
Cdd:TIGR00118 319 ARNVLEELLKKLFELKERKES----AWLEQINKWKKEYPLkMDYTEEG---IKPQQVIEELSRVTKDEAIVTTDVGQHQM 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 403 FAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGM 482
Cdd:TIGR00118 392 WAAQFYPFRKPRRFITSGGLGTMGFGLPAAIGAKVAKPESTVICITGDGSFQMNLQELSTAVQYDIPVKILILNNRYLGM 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 483 VRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKdRLVFIDIAVDRTEHVYPMQIKDGS 562
Cdd:TIGR00118 472 VRQWQELFYEERYSHTHMGSLPDFVKLAEAYGIKGIRIEKPEELDEKLKEALSSN-EPVLLDVVVDKPENVLPMVAPGGG 550
|
....*...
gi 655281819 563 MRDMWLSK 570
Cdd:TIGR00118 551 LDEMIGEK 558
|
|
| PRK06965 |
PRK06965 |
acetolactate synthase 3 catalytic subunit; Validated |
4-556 |
0e+00 |
|
acetolactate synthase 3 catalytic subunit; Validated
Pssm-ID: 180780 [Multi-domain] Cd Length: 587 Bit Score: 856.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAI 83
Cdd:PRK06965 21 SIGAEILMKALAAEGVEFIWGYPGGAVLYIYDELYKQDKIQHVLVRHEQAAVHAADGYARATGKVGVALVTSGPGVTNAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 84 TGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPK 163
Cdd:PRK06965 101 TGIATAYMDSIPMVVISGQVPTAAIGQDAFQECDTVGITRPIVKHNFLVKDVRDLAETVKKAFYIARTGRPGPVVVDIPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 164 DMTnpAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMG 243
Cdd:PRK06965 181 DVS--KTPCEYEYPKSVEMRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGVILANASRELRQLADLLGYPVTNTLMG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 244 LGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNA-KIIHIDIDPASISKMIKADVPIVG 322
Cdd:PRK06965 259 LGAYPASDKKFLGMLGMHGTYEANMAMQHCDVLIAIGARFDDRVIGNPAHFASRPrKIIHIDIDPSSISKRVKVDIPIVG 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 323 PVESVLSEMLTILKEIGEQPDKAALDAWWKQIDEWRGDGALfPYDKgDGNLIKPQQVIETLCEVTKGDAFVTSDVGQHQM 402
Cdd:PRK06965 339 DVKEVLKELIEQLQTAEHGPDADALAQWWKQIEGWRSRDCL-KYDR-ESEIIKPQYVVEKLWELTDGDAFVCSDVGQHQM 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 403 FAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGM 482
Cdd:PRK06965 417 WAAQFYRFNEPRRWINSGGLGTMGVGLPYAMGIKMAHPDDDVVCITGEGSIQMCIQELSTCLQYDTPVKIISLNNRYLGM 496
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 655281819 483 VRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLVFIDIAVDRTEHVYPM 556
Cdd:PRK06965 497 VRQWQEIEYSKRYSHSYMDALPDFVKLAEAYGHVGMRIEKTSDVEPALREALRLKDRTVFLDFQTDPTENVWPM 570
|
|
| PRK09107 |
PRK09107 |
acetolactate synthase 3 catalytic subunit; Validated |
4-556 |
0e+00 |
|
acetolactate synthase 3 catalytic subunit; Validated
Pssm-ID: 236380 [Multi-domain] Cd Length: 595 Bit Score: 766.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAI 83
Cdd:PRK09107 11 MTGAEMVVQALKDQGVEHIFGYPGGAVLPIYDEIFQQDDIQHILVRHEQGAGHAAEGYARSTGKPGVVLVTSGPGATNAV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 84 TGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPK 163
Cdd:PRK09107 91 TPLQDALMDSIPLVCITGQVPTHLIGSDAFQECDTVGITRPCTKHNWLVKDVNDLARVIHEAFHVATSGRPGPVVVDIPK 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 164 DMTnpAEKFEYIYPKKVKL-RSYSPAVRGHSGQIRKAAEMLLAAKRPIVYS--GGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK09107 171 DVQ--FATGTYTPPQKAPVhVSYQPKVKGDAEAITEAVELLANAKRPVIYSggGVINSGPEASRLLRELVELTGFPITST 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK09107 249 LMGLGAYPASGKNWLGMLGMHGTYEANMAMHDCDVMLCVGARFDDRITGRLDAFSPNSKKIHIDIDPSSINKNVRVDVPI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKEIGEQPDKAALDAWWKQIDEWRGDGALfPYdKGDGNLIKPQQVIETLCEVTKG-DAFVTSDVGQ 399
Cdd:PRK09107 329 IGDVGHVLEDMLRLWKARGKKPDKEALADWWGQIARWRARNSL-AY-TPSDDVIMPQYAIQRLYELTKGrDTYITTEVGQ 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 400 HQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGV 479
Cdd:PRK09107 407 HQMWAAQFFGFEEPNRWMTSGGLGTMGYGLPAALGVQIAHPDALVIDIAGDASIQMCIQEMSTAVQYNLPVKIFILNNQY 486
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 655281819 480 LGMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMkDRLVFIDIAVDRTEHVYPM 556
Cdd:PRK09107 487 MGMVRQWQQLLHGNRLSHSYTEAMPDFVKLAEAYGAVGIRCEKPGDLDDAIQEMIDV-DKPVIFDCRVANLENCFPM 562
|
|
| IlvB |
COG0028 |
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ... |
4-560 |
0e+00 |
|
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439799 [Multi-domain] Cd Length: 548 Bit Score: 765.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAI 83
Cdd:COG0028 3 MTGADALVEALEAEGVETVFGVPGGAILPLYDALRRQSGIRHILVRHEQGAAFMADGYARATGKPGVCLVTSGPGATNLV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 84 TGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPK 163
Cdd:COG0028 83 TGLADAYMDSVPVLAITGQVPTSLIGRGAFQEVDQVGLFRPITKWSYLVTDPEDLPEVLRRAFRIATSGRPGPVVLDIPK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 164 DMTnpAEKFEYiYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMG 243
Cdd:COG0028 163 DVQ--AAEAEE-EPAPPELRGYRPRPAPDPEAIEEAAELLAAAKRPVILAGGGARRAGAAEELRALAERLGAPVVTTLMG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 244 LGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIVGP 323
Cdd:COG0028 240 KGAFPEDHPLYLGMLGMHGTPAANEALAEADLVLAVGARFDDRVTGNWDEFAPDAKIIHIDIDPAEIGKNYPVDLPIVGD 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 324 VESVLSEMLTILKeigeqPDKAALDAWWKQIDEWRGDgALFPYDKGDGnLIKPQQVIETLCEVTKGDAFVTSDVGQHQMF 403
Cdd:COG0028 320 AKAVLAALLEALE-----PRADDRAAWLARIAAWRAE-YLAAYAADDG-PIKPQRVIAALREALPDDAIVVTDVGQHQMW 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 404 AAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMV 483
Cdd:COG0028 393 AARYLRFRRPRRFLTSGGLGTMGYGLPAAIGAKLARPDRPVVAITGDGGFQMNLQELATAVRYGLPVKVVVLNNGGLGMV 472
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 655281819 484 RQWQDMAYNGRHSHSYVeSLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVDRTEHVYPMQIKD 560
Cdd:COG0028 473 RQWQELFYGGRYSGTDL-PNPDFAKLAEAFGAKGERVETPEELEAALEEALA-SDGPALIDVRVDPEENPPGATLDE 547
|
|
| PRK08527 |
PRK08527 |
acetolactate synthase large subunit; |
4-573 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 181458 [Multi-domain] Cd Length: 563 Bit Score: 730.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAI 83
Cdd:PRK08527 3 LSGSQMVCEALKEEGVKVVFGYPGGAILNIYDEIYKQNYFKHILTRHEQAAVHAADGYARASGKVGVAIVTSGPGFTNAV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 84 TGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPK 163
Cdd:PRK08527 83 TGLATAYMDSIPLVLISGQVPNSLIGTDAFQEIDAVGISRPCVKHNYLVKSIEELPRILKEAFYIARSGRPGPVHIDIPK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 164 DMTnpAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMG 243
Cdd:PRK08527 163 DVT--ATLGEFEYPKEISLKTYKPTYKGNSRQIKKAAEAIKEAKKPLFYLGGGAILSNASEEIRELVKKTGIPAVETLMA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 244 LGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIVGP 323
Cdd:PRK08527 241 RGVLRSDDPLLLGMLGMHGSYAANMAMSECDLLISLGARFDDRVTGKLSEFAKHAKIIHVDIDPSSISKIVNADYPIVGD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 324 VESVLSEMLTILKEIGEQpdkaALDAWWKQIDEWRgdgALFPYDKGDGN-LIKPQQVIETLCEVTKGDAFVTSDVGQHQM 402
Cdd:PRK08527 321 LKNVLKEMLEELKEENPT----TYKEWREILKRYN---ELHPLSYEDSDeVLKPQWVIERVGELLGDDAIISTDVGQHQM 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 403 FAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGM 482
Cdd:PRK08527 394 WVAQFYPFNYPRQLATSGGLGTMGYGLPAALGAKLAVPDKVVINFTGDGSILMNIQELMTAVEYKIPVINIILNNNFLGM 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 483 VRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVDRTEHVYPMQIKDGS 562
Cdd:PRK08527 474 VRQWQTFFYEERYSETDLSTQPDFVKLAESFGGIGFRVTTKEEFDKALKEALE-SDKVALIDVKIDRFENVLPMVPAGGA 552
|
570
....*....|.
gi 655281819 563 MRDMWLSKTER 573
Cdd:PRK08527 553 LYNMILPKKKD 563
|
|
| PRK07418 |
PRK07418 |
acetolactate synthase large subunit; |
5-556 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 236014 [Multi-domain] Cd Length: 616 Bit Score: 690.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 5 SGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFK---EPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATN 81
Cdd:PRK07418 20 TGAYALMDSLKRHGVKHIFGYPGGAILPIYDELYKaeaEGWLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPGATN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 82 AITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDI 161
Cdd:PRK07418 100 LVTGIATAQMDSVPMVVITGQVPRPAIGTDAFQETDIFGITLPIVKHSYVVRDPSDMARIVAEAFHIASSGRPGPVLIDI 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 162 PKDMTNpaEKFEYI--YPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTN 239
Cdd:PRK07418 180 PKDVGQ--EEFDYVpvEPGSVKPPGYRPTVKGNPRQINAALKLIEEAERPLLYVGGGAISAGAHAELKELAERFQIPVTT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 240 TLMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVP 319
Cdd:PRK07418 258 TLMGKGAFDEHHPLSVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDEFASRAKVIHIDIDPAEVGKNRRPDVP 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 320 IVGPVESVLSEMLTILKEIGEQPDKAaldAWWKQIDEWRGDGALF-PYDKGDgnlIKPQQVIETLCEVTKgDAFVTSDVG 398
Cdd:PRK07418 338 IVGDVRKVLVKLLERSLEPTTPPRTQ---AWLERINRWKQDYPLVvPPYEGE---IYPQEVLLAVRDLAP-DAYYTTDVG 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 399 QHQMFAAQYYRfNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNG 478
Cdd:PRK07418 411 QHQMWAAQFLR-NGPRRWISSAGLGTMGFGMPAAMGVKVALPDEEVICIAGDASFLMNIQELGTLAQYGINVKTVIINNG 489
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 655281819 479 VLGMVRQWQDMAYNGRHSHSYVE-SLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVDRTEHVYPM 556
Cdd:PRK07418 490 WQGMVRQWQESFYGERYSASNMEpGMPDFVKLAEAFGVKGMVISERDQLKDAIAEALA-HDGPVLIDVHVRRDENCYPM 567
|
|
| PRK06048 |
PRK06048 |
acetolactate synthase large subunit; |
1-556 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 180368 [Multi-domain] Cd Length: 561 Bit Score: 689.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEpEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK06048 5 TEKMTGARAIIKCLEKEGVEVIFGYPGGAIIPVYDELYDS-DLRHILVRHEQAAAHAADGYARATGKVGVCVATSGPGAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK06048 84 NLVTGIATAYMDSVPIVALTGQVPRSMIGNDAFQEADITGITMPITKHNYLVQDAKDLPRIIKEAFHIASTGRPGPVLID 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKDMTNpaEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK06048 164 LPKDVTT--AEIDFDYPDKVELRGYKPTYKGNPQQIKRAAELIMKAERPIIYAGGGVISSNASEELVELAETIPAPVTTT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK06048 242 LMGIGAIPTEHPLSLGMLGMHGTKYANYAIQESDLIIAVGARFDDRVTGKLASFAPNAKIIHIDIDPAEISKNVKVDVPI 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEmltILKEIGEQPDKaaldAWWKQIDEWRGDGALFpYdKGDGNLIKPQQVIETLCEVTKgDAFVTSDVGQH 400
Cdd:PRK06048 322 VGDAKQVLKS---LIKYVQYCDRK----EWLDKINQWKKEYPLK-Y-KEREDVIKPQYVIEQIYELCP-DAIIVTEVGQH 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 401 QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVL 480
Cdd:PRK06048 392 QMWAAQYFKYKYPRTFITSGGLGTMGYGFPAAIGAKVGKPDKTVIDIAGDGSFQMNSQELATAVQNDIPVIVAILNNGYL 471
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 655281819 481 GMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMkDRLVFIDIAVDRTEHVYPM 556
Cdd:PRK06048 472 GMVRQWQELFYDKRYSHTCIKGSVDFVKLAEAYGALGLRVEKPSEVRPAIEEAVAS-DRPVVIDFIVECEENVSPM 546
|
|
| PRK07789 |
PRK07789 |
acetolactate synthase 1 catalytic subunit; Validated |
1-556 |
0e+00 |
|
acetolactate synthase 1 catalytic subunit; Validated
Pssm-ID: 236098 [Multi-domain] Cd Length: 612 Bit Score: 674.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK07789 28 PERMTGAQAVVRSLEELGVDVVFGIPGGAILPVYDPLFDSTKVRHVLVRHEQGAGHAAEGYAQATGRVGVCMATSGPGAT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK07789 108 NLVTPIADANMDSVPVVAITGQVGRGLIGTDAFQEADIVGITMPITKHNFLVTDADDIPRVIAEAFHIASTGRPGPVLVD 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKDMTNpaEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK07789 188 IPKDALQ--AQTTFSWPPRMDLPGYRPVTKPHGKQIREAAKLIAAARRPVLYVGGGVIRAEASAELRELAELTGIPVVTT 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK07789 266 LMARGAFPDSHPQHLGMPGMHGTVAAVAALQRSDLLIALGARFDDRVTGKLDSFAPDAKVIHADIDPAEIGKNRHADVPI 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKEIGEQPDKAALDAWWKQIDEWRGDgalFP--YDKGDGNLIKPQQVIETLCEVTKGDAFVTSDVG 398
Cdd:PRK07789 346 VGDVKEVIAELIAALRAEHAAGGKPDLTAWWAYLDGWRET---YPlgYDEPSDGSLAPQYVIERLGEIAGPDAIYVAGVG 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 399 QHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNG 478
Cdd:PRK07789 423 QHQMWAAQFIDYEKPRTWLNSGGLGTMGYAVPAAMGAKVGRPDKEVWAIDGDGCFQMTNQELATCAIEGIPIKVALINNG 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 479 VLGMVRQWQDMAYNGRHS----HSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLVFIDIAVDRTEHVY 554
Cdd:PRK07789 503 NLGMVRQWQTLFYEERYSntdlHTHSHRIPDFVKLAEAYGCVGLRCEREEDVDAVIEKARAINDRPVVIDFVVGKDAMVW 582
|
..
gi 655281819 555 PM 556
Cdd:PRK07789 583 PM 584
|
|
| PRK07710 |
PRK07710 |
acetolactate synthase large subunit; |
2-556 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 236076 [Multi-domain] Cd Length: 571 Bit Score: 627.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 2 ELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEpEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATN 81
Cdd:PRK07710 14 KLMTGAQMLIEALEKEGVEVIFGYPGGAVLPLYDALYDC-GIPHILTRHEQGAIHAAEGYARISGKPGVVIATSGPGATN 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 82 AITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDI 161
Cdd:PRK07710 93 VVTGLADAMIDSLPLVVFTGQVATSVIGSDAFQEADIMGITMPVTKHNYQVRKASDLPRIIKEAFHIATTGRPGPVLIDI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 162 PKDMTnpAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTL 241
Cdd:PRK07710 173 PKDMV--VEEGEFCYDVQMDLPGYQPNYEPNLLQIRKLVQAVSVAKKPVILAGAGVLHAKASKELTSYAEQQEIPVVHTL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 242 MGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIV 321
Cdd:PRK07710 251 LGLGGFPADHPLFLGMAGMHGTYTANMALYECDLLINIGARFDDRVTGNLAYFAKEATVAHIDIDPAEIGKNVPTEIPIV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 322 GPVESVLSEMLtilKEIGEQPDKaalDAWWKQIDEWRGDGALFPYDKGDGnlIKPQQVIETLCEVTKGDAFVTSDVGQHQ 401
Cdd:PRK07710 331 ADAKQALQVLL---QQEGKKENH---HEWLSLLKNWKEKYPLSYKRNSES--IKPQKAIEMLYEITKGEAIVTTDVGQHQ 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 402 MFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLG 481
Cdd:PRK07710 403 MWAAQYYPFKTPDKWVTSGGLGTMGFGLPAAIGAQLAKPDETVVAIVGDGGFQMTLQELSVIKELSLPVKVVILNNEALG 482
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 655281819 482 MVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMkDRLVFIDIAVDRTEHVYPM 556
Cdd:PRK07710 483 MVRQWQEEFYNQRYSHSLLSCQPDFVKLAEAYGIKGVRIDDELEAKEQLQHAIEL-QEPVVIDCRVLQSEKVMPM 556
|
|
| PRK06276 |
PRK06276 |
acetolactate synthase large subunit; |
4-566 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 235766 [Multi-domain] Cd Length: 586 Bit Score: 624.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEpEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAI 83
Cdd:PRK06276 1 MKGAEAIIKALEAEGVKIIFGYPGGALLPFYDALYDS-DLIHILTRHEQAAAHAADGYARASGKVGVCVATSGPGATNLV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 84 TGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPK 163
Cdd:PRK06276 80 TGIATAYADSSPVIALTGQVPTKLIGNDAFQEIDALGIFMPITKHNFQIKKPEEIPEIFRAAFEIAKTGRPGPVHIDLPK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 164 DM-TNPAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLM 242
Cdd:PRK06276 160 DVqEGELDLEKYPIPAKIDLPGYKPTTFGHPLQIKKAAELIAEAERPVILAGGGVIISGASEELIELSELVKIPVCTTLM 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 243 GLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIVG 322
Cdd:PRK06276 240 GKGAFPEDHPLALGMVGMHGTKAANYSVTESDVLIAIGCRFSDRTTGDISSFAPNAKIIHIDIDPAEIGKNVRVDVPIVG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 323 PVESVLSEMLTILKEigEQPDKAalDAWWKQIDEWRGDGalFPYDKGDGNLIKPQQVIETLCEVTKG-----DAFVTSDV 397
Cdd:PRK06276 320 DAKNVLRDLLAELMK--KEIKNK--SEWLERVKKLKKES--IPRMDFDDKPIKPQRVIKELMEVLREidpskNTIITTDV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 398 GQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNN 477
Cdd:PRK06276 394 GQNQMWMAHFFKTSAPRSFISSGGLGTMGFGFPAAIGAKVAKPDANVIAITGDGGFLMNSQELATIAEYDIPVVICIFDN 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 478 GVLGMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFaMKDRLVFIDIAVDRTEhVYPMQ 557
Cdd:PRK06276 474 RTLGMVYQWQNLYYGKRQSEVHLGETPDFVKLAESYGVKADRVEKPDEIKEALKEAI-KSGEPYLLDIIIDPAE-ALPMV 551
|
....*....
gi 655281819 558 IKDGSMRDM 566
Cdd:PRK06276 552 PPGGNLTNI 560
|
|
| ilvB |
CHL00099 |
acetohydroxyacid synthase large subunit |
18-556 |
0e+00 |
|
acetohydroxyacid synthase large subunit
Pssm-ID: 214363 [Multi-domain] Cd Length: 585 Bit Score: 620.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 18 GVKHIYGYPGGALLHVYDALF---KEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGIATAYMDSI 94
Cdd:CHL00099 24 GVKHIFGYPGGAILPIYDELYaweKKGLIKHILVRHEQGAAHAADGYARSTGKVGVCFATSGPGATNLVTGIATAQMDSV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 95 PMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKDMTnpAEKFEY 174
Cdd:CHL00099 104 PLLVITGQVGRAFIGTDAFQEVDIFGITLPIVKHSYVVRDARDISRIVAEAFYIAKHGRPGPVLIDIPKDVG--LEKFDY 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 175 IYPKK----VKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGLGGFPGT 250
Cdd:CHL00099 182 YPPEPgntiIKILGCRPIYKPTIKRIEQAAKLILQSSQPLLYVGGGAIISDAHQEITELAELYKIPVTTTLMGKGIFDED 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 251 DRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIVGPVESVLSE 330
Cdd:CHL00099 262 HPLCLGMLGMHGTAYANFAVSECDLLIALGARFDDRVTGKLDEFACNAQVIHIDIDPAEIGKNRIPQVAIVGDVKKVLQE 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 331 MLTILKEIGEQPDKAALDAWWKQIDEWRGDGALF-PYDKgdgNLIKPQQVIETLCEVtKGDAFVTSDVGQHQMFAAQYYR 409
Cdd:CHL00099 342 LLELLKNSPNLLESEQTQAWRERINRWRKEYPLLiPKPS---TSLSPQEVINEISQL-APDAYFTTDVGQHQMWAAQFLK 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 410 FnKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDM 489
Cdd:CHL00099 418 C-KPRKWLSSAGLGTMGYGLPAAIGAQIAHPNELVICISGDASFQMNLQELGTIAQYNLPIKIIIINNKWQGMVRQWQQA 496
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 655281819 490 AYNGRHSHSYV-ESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRlVFIDIAVDRTEHVYPM 556
Cdd:CHL00099 497 FYGERYSHSNMeEGAPDFVKLAEAYGIKGLRIKSRKDLKSSLKEALDYDGP-VLIDCQVIEDENCYPM 563
|
|
| PRK06725 |
PRK06725 |
acetolactate synthase large subunit; |
2-556 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 180672 [Multi-domain] Cd Length: 570 Bit Score: 603.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 2 ELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFkEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATN 81
Cdd:PRK06725 13 EEVTGAGHVIQCLKKLGVTTVFGYPGGAILPVYDALY-ESGLKHILTRHEQAAIHAAEGYARASGKVGVVFATSGPGATN 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 82 AITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDI 161
Cdd:PRK06725 92 LVTGLADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAESGRPGPVLIDI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 162 PKDMTNpaEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTL 241
Cdd:PRK06725 172 PKDVQN--EKVTSFYNEVVEIPGYKPEPRPDSMKLREVAKAISKAKRPLLYIGGGVIHSGGSEELIEFARENRIPVVSTL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 242 MGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIV 321
Cdd:PRK06725 250 MGLGAYPPGDPLFLGMLGMHGTYAANMAVTECDLLLALGVRFDDRVTGKLELFSPHSKKVHIDIDPSEFHKNVAVEYPVV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 322 GPVESVLSEMLtilkeigEQPDKAALDAWWKQIDEWRGDGALfPYDKGDGNLiKPQQVIETLCEVTKGDAFVTSDVGQHQ 401
Cdd:PRK06725 330 GDVKKALHMLL-------HMSIHTQTDEWLQKVKTWKEEYPL-SYKQKESEL-KPQHVINLVSELTNGEAIVTTEVGQHQ 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 402 MFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLG 481
Cdd:PRK06725 401 MWAAHFYKAKNPRTFLTSGGLGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENNIPVKVFIINNKFLG 480
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 655281819 482 MVRQWQDMAYNGRHSHSYVESlPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLVfIDIAVDRTEHVYPM 556
Cdd:PRK06725 481 MVRQWQEMFYENRLSESKIGS-PDFVKVAEAYGVKGLRATNSTEAKQVMLEAFAHEGPVV-VDFCVEEGENVFPM 553
|
|
| PRK08978 |
PRK08978 |
acetolactate synthase 2 catalytic subunit; Reviewed |
6-556 |
0e+00 |
|
acetolactate synthase 2 catalytic subunit; Reviewed
Pssm-ID: 181601 [Multi-domain] Cd Length: 548 Bit Score: 579.53 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPeVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:PRK08978 3 GAQWVVHALRAQGVDTVFGYPGGAIMPVYDALYDGG-VEHLLCRHEQGAAMAAIGYARATGKVGVCIATSGPGATNLITG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKDM 165
Cdd:PRK08978 82 LADALLDSVPVVAITGQVSSPLIGTDAFQEIDVLGLSLACTKHSFLVQSLEELPEIMAEAFEIASSGRPGPVLVDIPKDI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 166 TNPAEKFEYIYPKKVKLRSYSPAvrghsgQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGLG 245
Cdd:PRK08978 162 QLAEGELEPHLTTVENEPAFPAA------ELEQARALLAQAKKPVLYVGGGVGMAGAVPALREFLAATGMPAVATLKGLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 246 GFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIVGPVE 325
Cdd:PRK08978 236 AVEADHPYYLGMLGMHGTKAANLAVQECDLLIAVGARFDDRVTGKLNTFAPHAKVIHLDIDPAEINKLRQAHVALQGDLN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 326 SVLSEMltilkeigEQPdkAALDAWWKQIDEWRGDGAlFPYDKgDGNLIKPQQVIETLCEVTKGDAFVTSDVGQHQMFAA 405
Cdd:PRK08978 316 ALLPAL--------QQP--LNIDAWRQHCAQLRAEHA-WRYDH-PGEAIYAPALLKQLSDRKPADTVVTTDVGQHQMWVA 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 406 QYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQ 485
Cdd:PRK08978 384 QHMRFTRPENFITSSGLGTMGFGLPAAIGAQVARPDDTVICVSGDGSFMMNVQELGTIKRKQLPVKIVLLDNQRLGMVRQ 463
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 655281819 486 WQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLvFIDIAVDRTEHVYPM 556
Cdd:PRK08978 464 WQQLFFDERYSETDLSDNPDFVMLASAFGIPGQTITRKDQVEAALDTLLNSEGPY-LLHVSIDELENVWPL 533
|
|
| PRK07282 |
PRK07282 |
acetolactate synthase large subunit; |
5-556 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 180919 [Multi-domain] Cd Length: 566 Bit Score: 566.76 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 5 SGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAIT 84
Cdd:PRK07282 11 SGSDLVLETLRDLGVDTIFGYPGGAVLPLYDAIYNFEGIRHILARHEQGALHEAEGYAKSTGKLGVAVVTSGPGATNAIT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 85 GIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKD 164
Cdd:PRK07282 91 GIADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQIRETADIPRIITEAVHIATTGRPGPVVIDLPKD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 165 MTnpAEKFEYIYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGL 244
Cdd:PRK07282 171 VS--ALETDFIYDPEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVILAGGGINYAEAATELNAFAERYQIPVVTTLLGQ 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 245 GGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPIVGPV 324
Cdd:PRK07282 249 GTIATSHPLFLGMGGMHGSYAANIAMTEADFMINIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIIKTDIPVVGDA 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 325 ESVLSEMLTilkeigEQPDKAALDAWWKQIDEwrgDGALFP-YDKgDGNLIKPQQVIETLCEVTKGDAFVTSDVGQHQMF 403
Cdd:PRK07282 329 KKALQMLLA------EPTVHNNTEKWIEKVTK---DKNRVRsYDK-KERVVQPQAVIERIGELTNGDAIVVTDVGQHQMW 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 404 AAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMV 483
Cdd:PRK07282 399 AAQYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVILFVGDGGFQMTNQELAILNIYKVPIKVVMLNNHSLGMV 478
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 655281819 484 RQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEeaFAMKDRLVFIDIAVDRTEHVYPM 556
Cdd:PRK07282 479 RQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKHYKFDNPETLAQDLE--VITEDVPMLIEVDISRKEHVLPM 549
|
|
| PRK08155 |
PRK08155 |
acetolactate synthase large subunit; |
1-556 |
0e+00 |
|
acetolactate synthase large subunit;
Pssm-ID: 181257 [Multi-domain] Cd Length: 564 Bit Score: 543.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK08155 10 RKRFTGAELIVRLLERQGIRIVTGIPGGAILPLYDALSQSTQIRHILARHEQGAGFIAQGMARTTGKPAVCMACSGPGAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK08155 90 NLVTAIADARLDSIPLVCITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVRDIEELPQVISDAFRIAQSGRPGPVWID 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKDMTNPAEKFEYIYPkkVKLRSYSPAVRGHSgqIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNT 240
Cdd:PRK08155 170 IPKDVQTAVIELEALPA--PAEKDAAPAFDEES--IRDAAAMINAAKRPVLYLGGGVINSGAPARARELAEKAQLPTTMT 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 241 LMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:PRK08155 246 LMALGMLPKAHPLSLGMLGMHGARSTNYILQEADLLIVLGARFDDRAIGKTEQFCPNAKIIHVDIDRAELGKIKQPHVAI 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKeigEQPDKaaldAWWKQIDEWRGDgalFPYD-KGDGNLIKPQQVIETLCEVTKGDAFVTSDVGQ 399
Cdd:PRK08155 326 QADVDDVLAQLLPLVE---AQPRA----EWHQLVADLQRE---FPCPiPKADDPLSHYGLINAVAACVDDNAIITTDVGQ 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 400 HQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGV 479
Cdd:PRK08155 396 HQMWTAQAYPLNRPRQWLTSGGLGTMGFGLPAAIGAALANPERKVLCFSGDGSLMMNIQEMATAAENQLDVKIILMNNEA 475
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 655281819 480 LGMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRlVFIDIAVDRTEHVYPM 556
Cdd:PRK08155 476 LGLVHQQQSLFYGQRVFAATYPGKINFMQIAAGFGLETCDLNNEADPQAALQEAINRPGP-ALIHVRIDAEEKVYPM 551
|
|
| PLN02470 |
PLN02470 |
acetolactate synthase |
6-566 |
0e+00 |
|
acetolactate synthase
Pssm-ID: 215261 [Multi-domain] Cd Length: 585 Bit Score: 524.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:PLN02470 15 GADILVEALEREGVDTVFAYPGGASMEIHQALTRSNCIRNVLCRHEQGEVFAAEGYAKASGKVGVCIATSGPGATNLVTG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKDM 165
Cdd:PLN02470 95 LADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYLVMDVEDIPRVIREAFFLASSGRPGPVLVDIPKDI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 166 TNpaekfEYIYP---KKVKLRSYS---PAVRGHSgQIRKAAEMLLAAKRPIVYSggGVILGGGSEALTEIAKSLNLPVTN 239
Cdd:PLN02470 175 QQ-----QLAVPnwnQPMKLPGYLsrlPKPPEKS-QLEQIVRLISESKRPVVYV--GGGCLNSSEELREFVELTGIPVAS 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 240 TLMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVP 319
Cdd:PLN02470 247 TLMGLGAFPASDELSLQMLGMHGTVYANYAVDSADLLLAFGVRFDDRVTGKLEAFASRASIVHIDIDPAEIGKNKQPHVS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 320 IVGPVESVLSEMLTILKEigEQPDKAALDAWWKQIDEWRgdgALFPYD-KGDGNLIKPQQVIETLCEVTKGDAFVTSDVG 398
Cdd:PLN02470 327 VCADVKLALQGLNKLLEE--RKAKRPDFSAWRAELDEQK---EKFPLSyPTFGDAIPPQYAIQVLDELTDGNAIISTGVG 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 399 QHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNG 478
Cdd:PLN02470 402 QHQMWAAQWYKYKEPRRWLTSGGLGAMGFGLPAAIGAAAANPDAIVVDIDGDGSFIMNIQELATIHVENLPVKIMVLNNQ 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 479 VLGMVRQWQDMAYNGRHSHSYV-------ESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVDRTE 551
Cdd:PLN02470 482 HLGMVVQWEDRFYKANRAHTYLgdpdaeaEIFPDFLKFAEGCKIPAARVTRKSDLREAIQKMLD-TPGPYLLDVIVPHQE 560
|
570
....*....|....*
gi 655281819 552 HVYPMQIKDGSMRDM 566
Cdd:PLN02470 561 HVLPMIPGGGTFKDI 575
|
|
| PRK06456 |
PRK06456 |
acetolactate synthase large subunit; |
3-569 |
4.04e-145 |
|
acetolactate synthase large subunit;
Pssm-ID: 180569 [Multi-domain] Cd Length: 572 Bit Score: 430.80 E-value: 4.04e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 3 LLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDAL---FKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGA 79
Cdd:PRK06456 1 MPTGARILVDSLKREGVKVIFGIPGLSNMQIYDAFvedLANGELRHVLMRHEQAAAHAADGYARASGVPGVCTATSGPGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 80 TNAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVV 159
Cdd:PRK06456 81 TNLVTGLITAYWDSSPVIAITGQVPRSVMGKMAFQEADAMGVFENVTKYVIGIKRIDEIPQWIKNAFYIATTGRPGPVVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 160 DIPKDMTNpaEKFEYI-YPKKVKLRSYSP-AVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPV 237
Cdd:PRK06456 161 DIPRDIFY--EKMEEIkWPEKPLVKGYRDfPTRIDRLALKKAAEILINAERPIILVGTGVVWSNATPEVLELAELLHIPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 238 TNTLMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKFCPN-AKIIHIDIDPASISKMIKA 316
Cdd:PRK06456 239 VSTFPGKTAIPHDHPLYFGPMGYYGRAEASMAALESDAMLVVGARFSDRTFTSYDEMVETrKKFIMVNIDPTDGEKAIKV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 317 DVPIVGPVESVLSEMLTILKEIGEQPDKAaldAWWKQIDEWRGDGALFPYDKGDGNLiKPQQVIETLCEVTKGDAFVTSD 396
Cdd:PRK06456 319 DVGIYGNAKIILRELIKAITELGQKRDRS---AWLKRVKEYKEYYSQFYYTEENGKL-KPWKIMKTIRQALPRDAIVTTG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 397 VGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLN 476
Cdd:PRK06456 395 VGQHQMWAEVFWEVLEPRTFLTSSGMGTMGFGLPAAMGAKLARPDKVVVDLDGDGSFLMTGTNLATAVDEHIPVISVIFD 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 477 NGVLGMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEafAMKDRL-VFIDIAVDRTEHVYP 555
Cdd:PRK06456 475 NRTLGLVRQVQDLFFGKRIVGVDYGPSPDFVKLAEAFGALGFNVTTYEDIEKSLKS--AIKEDIpAVIRVPVDKEELALP 552
|
570
....*....|....
gi 655281819 556 MQIKDGSMRDMWLS 569
Cdd:PRK06456 553 TLPPGGRLKQVILR 566
|
|
| PRK08322 |
PRK08322 |
acetolactate synthase large subunit; |
6-551 |
1.65e-125 |
|
acetolactate synthase large subunit;
Pssm-ID: 236239 [Multi-domain] Cd Length: 547 Bit Score: 379.56 E-value: 1.65e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPeVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:PRK08322 3 AADLFVKCLENEGVEYIFGIPGEENLDLLEALRDSS-IKLILTRHEQGAAFMAATYGRLTGKAGVCLSTLGPGATNLVTG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKDM 165
Cdd:PRK08322 82 VAYAQLGGMPMVAITGQKPIKRSKQGSFQIVDVVAMMAPLTKWTRQIVSPDNIPEVVREAFRLAEEERPGAVHLELPEDI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 166 TnpAEKfeyiYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGLG 245
Cdd:PRK08322 162 A--AEE----TDGKPLPRSYSRRPYASPKAIERAAEAIQAAKNPLILIGAGANRKTASKALTEFVDKTGIPFFTTQMGKG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 246 GFPGTDRQFLGMLGMH-GSYTaNMAMHHADVIFAVGArfdDRVVNGPAKFCPNA--KIIHIDIDPASISKMIKADVPIVG 322
Cdd:PRK08322 236 VIPETHPLSLGTAGLSqGDYV-HCAIEHADLIINVGH---DVIEKPPFFMNPNGdkKVIHINFLPAEVDPVYFPQVEVVG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 323 PVESVLSEMLTILKEIGEQPDKAAL---DAWWKQIDEWRGDGAlFPydkgdgnlIKPQQVIETLCEVTKGDAFVTSDVGQ 399
Cdd:PRK08322 312 DIANSLWQLKERLADQPHWDFPRFLkirEAIEAHLEEGADDDR-FP--------MKPQRIVADLRKVMPDDDIVILDNGA 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 400 HQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGV 479
Cdd:PRK08322 383 YKIWFARNYRAYEPNTCLLDNALATMGAGLPSAIAAKLVHPDRKVLAVCGDGGFMMNSQELETAVRLGLPLVVLILNDNA 462
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 655281819 480 LGMVRqWQDMAYNGRhsHSYVE-SLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVDRTE 551
Cdd:PRK08322 463 YGMIR-WKQENMGFE--DFGLDfGNPDFVKYAESYGAKGYRVESADDLLPTLEEALA-QPGVHVIDCPVDYSE 531
|
|
| PRK11269 |
PRK11269 |
glyoxylate carboligase; Provisional |
1-536 |
3.33e-116 |
|
glyoxylate carboligase; Provisional
Pssm-ID: 183066 [Multi-domain] Cd Length: 591 Bit Score: 356.98 E-value: 3.33e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARAT-GKAGVVLVTSGPGA 79
Cdd:PRK11269 1 MAKMRAVDAAVLVLEKEGVTTAFGVPGAAINPFYSAMRKHGGIRHILARHVEGASHMAEGYTRATaGNIGVCIGTSGPAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 80 TNAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVV 159
Cdd:PRK11269 81 TDMITGLYSASADSIPILCITGQAPRARLHKEDFQAVDIESIAKPVTKWAVTVREPALVPRVFQQAFHLMRSGRPGPVLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 160 DIPKDMTNPAEKFEY-IY-PKKVklrsYSPAvrGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPV 237
Cdd:PRK11269 161 DLPFDVQVAEIEFDPdTYePLPV----YKPA--ATRAQIEKALEMLNAAERPLIVAGGGVINADASDLLVEFAELTGVPV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 238 TNTLMGLGGFPGTDRQFLGMLGMHGSYT-ANMAMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKA 316
Cdd:PRK11269 235 IPTLMGWGAIPDDHPLMAGMVGLQTSHRyGNATLLASDFVLGIGNRWANRHTGSVEVYTKGRKFVHVDIEPTQIGRVFGP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 317 DVPIVGPVESVLSEMLTILKEI---GEQPDKAaldAWWKQIDEWRgdGALFPYDKGDGNLIKPQQVIETLCEVTKGDAFV 393
Cdd:PRK11269 315 DLGIVSDAKAALELLVEVAREWkaaGRLPDRS---AWVADCQERK--RTLLRKTHFDNVPIKPQRVYEEMNKAFGRDTCY 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 394 TSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIV 473
Cdd:PRK11269 390 VSTIGLSQIAAAQFLHVYKPRHWINCGQAGPLGWTIPAALGVRAADPDRNVVALSGDYDFQFLIEELAVGAQFNLPYIHV 469
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 655281819 474 NLNNGVLGMVRQWQ---DMAYNGRHSHSYVESLP------DFVKLAEAYGHVGIRITSLKDLKPKLEEAFAM 536
Cdd:PRK11269 470 LVNNAYLGLIRQAQrafDMDYCVQLAFENINSPElngygvDHVKVAEGLGCKAIRVFKPEDIAPALEQAKAL 541
|
|
| TPP_AHAS |
cd02015 |
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding ... |
374-556 |
6.39e-107 |
|
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate. 2-Acetolactate is the precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. In addition to requiring TPP and a divalent metal ion as cofactors, AHAS requires FAD.
Pssm-ID: 238973 [Multi-domain] Cd Length: 186 Bit Score: 318.67 E-value: 6.39e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 374 IKPQQVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSI 453
Cdd:cd02015 1 IKPQEVIKELSELTPGDAIVTTDVGQHQMWAAQYYRFKKPRSWLTSGGLGTMGFGLPAAIGAKVARPDKTVICIDGDGSF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 454 QMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEA 533
Cdd:cd02015 81 QMNIQELATAAQYNLPVKIVILNNGSLGMVRQWQELFYEGRYSHTTLDSNPDFVKLAEAYGIKGLRVEKPEELEAALKEA 160
|
170 180
....*....|....*....|...
gi 655281819 534 FAmKDRLVFIDIAVDRTEHVYPM 556
Cdd:cd02015 161 LA-SDGPVLLDVLVDPEENVLPM 182
|
|
| PRK08199 |
PRK08199 |
thiamine pyrophosphate protein; Validated |
6-548 |
4.82e-105 |
|
thiamine pyrophosphate protein; Validated
Pssm-ID: 181285 [Multi-domain] Cd Length: 557 Bit Score: 327.22 E-value: 4.82e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:PRK08199 10 GGQILVDALRANGVERVFCVPGESYLAVLDALHDETDIRVIVCRQEGGAAMMAEAYGKLTGRPGICFVTRGPGATNASIG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKDM 165
Cdd:PRK08199 90 VHTAFQDSTPMILFVGQVARDFREREAFQEIDYRRMFGPMAKWVAEIDDAARIPELVSRAFHVATSGRPGPVVLALPEDV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 166 -TNPAEkfeyiypkkVKLRSYSPAVRGHSG--QIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLM 242
Cdd:PRK08199 170 lSETAE---------VPDAPPYRRVAAAPGaaDLARLAELLARAERPLVILGGSGWTEAAVADLRAFAERWGLPVACAFR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 243 GLGGFPGTDRQFLGMLGmhgsYTANMAM----HHADVIFAVGARFDD------RVVNGPAkfcPNAKIIHIDIDPASISK 312
Cdd:PRK08199 241 RQDLFDNRHPNYAGDLG----LGINPALaariREADLVLAVGTRLGEvttqgyTLLDIPV---PRQTLVHVHPDAEELGR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 313 MIKADVPIVGPVESVLsEMLTILKEIGEQPDKAALDAWWKQIDEWRgdgalfPYDKGDGNLIKPqQVIETLCEVTKGDAF 392
Cdd:PRK08199 314 VYRPDLAIVADPAAFA-AALAALEPPASPAWAEWTAAAHADYLAWS------APLPGPGAVQLG-EVMAWLRERLPADAI 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 393 VTSDVGQHQMFAAQYYRFNKPNRWI--NSgglGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPV 470
Cdd:PRK08199 386 ITNGAGNYATWLHRFFRFRRYRTQLapTS---GSMGYGLPAAIAAKLLFPERTVVAFAGDGCFLMNGQELATAVQYGLPI 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 471 KIVNLNNGVLGMVRQWQDMAYNGRHSHSyveSL--PDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKdRLVFIDIAVD 548
Cdd:PRK08199 463 IVIVVNNGMYGTIRMHQEREYPGRVSGT---DLtnPDFAALARAYGGHGETVERTEDFAPAFERALASG-KPALIEIRID 538
|
|
| sulphoacet_xsc |
TIGR03457 |
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde ... |
7-550 |
3.38e-101 |
|
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde acetyltransferase, an enzyme of taurine utilization. Taurine, or 2-aminoethanesulfonate, can be used by bacteria as a source of carbon, nitrogen, and sulfur. [Central intermediary metabolism, Other]
Pssm-ID: 132497 [Multi-domain] Cd Length: 579 Bit Score: 317.96 E-value: 3.38e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 7 AEMVVRFLRDEGVKHIYGYPGGALLHVYDaLFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGI 86
Cdd:TIGR03457 5 SEAFVEVLVANGVTHAFGIMGSAFMDAMD-LFPPAGIRFIPVVHEQGAGHMADGFARVTGRMSMVIGQNGPGVTNCVTAI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 87 ATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRpGPVVVDIPKDmt 166
Cdd:TIGR03457 84 AAAYWAHTPVVIVTPEAGTKTIGLGGFQEADQLPMFQEFTKYQGHVRHPSRMAEVLNRCFERAWREM-GPAQLNIPRD-- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 167 npaekfeYIYPK-KVKLRSYSPAVRGHSG--QIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMG 243
Cdd:TIGR03457 161 -------YFYGEiDVEIPRPVRLDRGAGGatSLAQAARLLAEAKFPVIISGGGVVMGDAVEECKALAERLGAPVVNSYLH 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 244 LGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGAR---FDDRVVNGPAKFCPNAKIIHIDIDPASISKMIKADVPI 320
Cdd:TIGR03457 234 NDSFPASHPLWVGPLGYQGSKAAMKLISDADVVLALGTRlgpFGTLPQYGIDYWPKNAKIIQVDANAKMIGLVKKVTVGI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 321 VGPVESVLSEMLTILKEIGEQPDKAAL--------DAWWKQIDEWRGDGALFPYD------KGDGNLIKPQQVIETLCEV 386
Cdd:TIGR03457 314 CGDAKAAAAEILQRLAGKAGDANRAERkakiqaerSAWEQELSEMTHERDPFSLDmiveqrQEEGNWLHPRQVLRELEKA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 387 TKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQY 466
Cdd:TIGR03457 394 MPEDAIVSTDIGNINSVANSYLRFEKPRKFLAPMSFGNCGYAFPTIIGAKIAAPDRPVVAYAGDGAWGMSMNEIMTAVRH 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 467 GLPVKIVNLNNGVLGMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFA--MKDRLVFID 544
Cdd:TIGR03457 474 DIPVTAVVFRNRQWGAEKKNQVDFYNNRFVGTELESELSFAGIADAMGAKGVVVDKPEDVGPALKKAIAaqAEGKTTVIE 553
|
....*.
gi 655281819 545 IAVDRT 550
Cdd:TIGR03457 554 IVCTRE 559
|
|
| PRK08611 |
PRK08611 |
pyruvate oxidase; Provisional |
6-558 |
7.23e-101 |
|
pyruvate oxidase; Provisional
Pssm-ID: 181502 [Multi-domain] Cd Length: 576 Bit Score: 316.94 E-value: 7.23e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPE-VQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAIT 84
Cdd:PRK08611 6 AGEALVKLLQDWGIDHVYGIPGDSIDAVVDALRKEQDkIKFIQVRHEEVAALAAAAYAKLTGKIGVCLSIGGPGAIHLLN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 85 GIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRpGPVVVDIPKD 164
Cdd:PRK08611 86 GLYDAKMDHVPVLALAGQVTSDLLGTDFFQEVNLEKMFEDVAVYNHQIMSAENLPEIVNQAIRTAYEKK-GVAVLTIPDD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 165 MtnPAEKFEYIYPKKVKLrsYSPA-VRGHSGQIRKAAEMLLAAKRPIVysGGGVILGGGSEALTEIAKSLNLPVTNTLMG 243
Cdd:PRK08611 165 L--PAQKIKDTTNKTVDT--FRPTvPSPKPKDIKKAAKLINKAKKPVI--LAGLGAKHAKEELLAFAEKAKIPIIHTLPA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 244 LGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRvvngpaKFCPN-AKIIHIDIDPASISKMIKADVPIVG 322
Cdd:PRK08611 239 KGIIPDDHPYSLGNLGKIGTKPAYEAMQEADLLIMVGTNYPYV------DYLPKkAKAIQIDTDPANIGKRYPVNVGLVG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 323 PVESVLSEmLTilKEIGEQPDKAALDA-------WWKQIDEWRGDgalfpydkgDGNLIKPQQVIETLCEVTKGDAFVTS 395
Cdd:PRK08611 313 DAKKALHQ-LT--ENIKHVEDRRFLEAcqenmakWWKWMEEDENN---------ASTPIKPERVMAAIQKIADDDAVLSV 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 396 DVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNL 475
Cdd:PRK08611 381 DVGTVTVWSARYLNLGTNQKFIISSWLGTMGCGLPGAIAAKIAFPDRQAIAICGDGGFSMVMQDFVTAVKYKLPIVVVVL 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 476 NNGVLGMVRQWQDMAYNgrhsHSYVESL--PDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVDRTEHV 553
Cdd:PRK08611 461 NNQQLAFIKYEQQAAGE----LEYAIDLsdMDYAKFAEACGGKGYRVEKAEELDPAFEEALA-QDKPVIIDVYVDPNAAP 535
|
....*
gi 655281819 554 YPMQI 558
Cdd:PRK08611 536 LPGKI 540
|
|
| PRK08266 |
PRK08266 |
hypothetical protein; Provisional |
1-555 |
1.28e-96 |
|
hypothetical protein; Provisional
Pssm-ID: 181337 [Multi-domain] Cd Length: 542 Bit Score: 304.63 E-value: 1.28e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEP-EVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGA 79
Cdd:PRK08266 1 MTTMTGGEAIVAGLVAHGVDTVFGLPGAQLYWLFDALYKAGdRIRVIHTRHEQAAGYMAFGYARSTGRPGVCSVVPGPGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 80 TNAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQ--ET-DMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGP 156
Cdd:PRK08266 81 LNAGAALLTAYGCNSPVLCLTGQIPSALIGKGRGHlhEMpDQLATLRSFTKWAERIEHPSEAPALVAEAFQQMLSGRPRP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 157 VVVDIPKDM------TNPAEKFEYIYPkkvklrsysPAVrgHSGQIRKAAEMLLAAKRPIVYsgGGVILGGGSEALTEIA 230
Cdd:PRK08266 161 VALEMPWDVfgqrapVAAAPPLRPAPP---------PAP--DPDAIAAAAALIAAAKNPMIF--VGGGAAGAGEEIRELA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 231 KSLNLPVTNTLMGLGGFPgtDRQFLGMlgmhgsytaNMA-----MHHADVIFAVGARFDDRVVNgpAKFCP-NAKIIHID 304
Cdd:PRK08266 228 EMLQAPVVAFRSGRGIVS--DRHPLGL---------NFAaayelWPQTDVVIGIGSRLELPTFR--WPWRPdGLKVIRID 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 305 IDPASISKMiKADVPIVGPVESVLSEMLTILKEIGEQ-PDK----AALDAWWK-QIDEwrgdgalfpydkgdgnlIKPQ- 377
Cdd:PRK08266 295 IDPTEMRRL-KPDVAIVADAKAGTAALLDALSKAGSKrPSRraelRELKAAARqRIQA-----------------VQPQa 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 378 QVIETLCEVTKGDAFVTSDVGqhQMFAAQYYRF--NKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQM 455
Cdd:PRK08266 357 SYLRAIREALPDDGIFVDELS--QVGFASWFAFpvYAPRTFVTCGYQGTLGYGFPTALGAKVANPDRPVVSITGDGGFMF 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 456 NIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGRhshsYVES-L--PDFVKLAEAYGHVGIRITSLKDLKPKLEE 532
Cdd:PRK08266 435 GVQELATAVQHNIGVVTVVFNNNAYGNVRRDQKRRFGGR----VVASdLvnPDFVKLAESFGVAAFRVDSPEELRAALEA 510
|
570 580
....*....|....*....|...
gi 655281819 533 AFAmKDRLVFIDIAVDRTEHVYP 555
Cdd:PRK08266 511 ALA-HGGPVLIEVPVPRGSEASP 532
|
|
| PRK07525 |
PRK07525 |
sulfoacetaldehyde acetyltransferase; Validated |
8-549 |
7.45e-94 |
|
sulfoacetaldehyde acetyltransferase; Validated
Pssm-ID: 236042 [Multi-domain] Cd Length: 588 Bit Score: 298.84 E-value: 7.45e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 8 EMVVRFLRDEGVKHIYGYPGGALLHVYDaLFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGIA 87
Cdd:PRK07525 10 EAFVETLQAHGITHAFGIIGSAFMDASD-LFPPAGIRFIDVAHEQNAGHMADGYTRVTGRMGMVIGQNGPGITNFVTAVA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 88 TAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRpGPVVVDIPKDMTN 167
Cdd:PRK07525 89 TAYWAHTPVVLVTPQAGTKTIGQGGFQEAEQMPMFEDMTKYQEEVRDPSRMAEVLNRVFDKAKRES-GPAQINIPRDYFY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 168 PAEKFEYIYPKKVKlrsyspavRGHSG--QIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGLG 245
Cdd:PRK07525 168 GVIDVEIPQPVRLE--------RGAGGeqSLAEAAELLSEAKFPVILSGAGVVLSDAIEECKALAERLDAPVACGYLHND 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 246 GFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFddrvvnGPAKFCP---------NAKIIHIDIDPASISKMIKA 316
Cdd:PRK07525 240 AFPGSHPLWVGPLGYNGSKAAMELIAKADVVLALGTRL------NPFGTLPqygidywpkDAKIIQVDINPDRIGLTKKV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 317 DVPIVGPVESVLSEMLTILKEI--GEQPDKAALD-------AWWKQIDEW---RGDGALFPYDKG---DGNLIKPQQVIE 381
Cdd:PRK07525 314 SVGICGDAKAVARELLARLAERlaGDAGREERKAliaaeksAWEQELSSWdheDDDPGTDWNEEArarKPDYMHPRQALR 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 382 TLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELS 461
Cdd:PRK07525 394 EIQKALPEDAIVSTDIGNNCSIANSYLRFEKGRKYLAPGSFGNCGYAFPAIIGAKIACPDRPVVGFAGDGAWGISMNEVM 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 462 TCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLV 541
Cdd:PRK07525 474 TAVRHNWPVTAVVFRNYQWGAEKKNQVDFYNNRFVGTELDNNVSYAGIAEAMGAEGVVVDTQEELGPALKRAIDAQNEGK 553
|
570
....*....|
gi 655281819 542 --FIDIAVDR 549
Cdd:PRK07525 554 ttVIEIMCNQ 563
|
|
| PRK08617 |
PRK08617 |
acetolactate synthase AlsS; |
5-557 |
8.19e-94 |
|
acetolactate synthase AlsS;
Pssm-ID: 236312 [Multi-domain] Cd Length: 552 Bit Score: 297.92 E-value: 8.19e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 5 SGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALfKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAIT 84
Cdd:PRK08617 6 YGADLVVDSLINQGVKYVFGIPGAKIDRVFDAL-EDSGPELIVTRHEQNAAFMAAAIGRLTGKPGVVLVTSGPGVSNLAT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 85 GIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKD 164
Cdd:PRK08617 85 GLVTATAEGDPVVAIGGQVKRADRLKRTHQSMDNVALFRPITKYSAEVQDPDNLSEVLANAFRAAESGRPGAAFVSLPQD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 165 MTNPAEKFEYIYPK-KVKLRSYSPAvrghsgQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMG 243
Cdd:PRK08617 165 VVDAPVTSKAIAPLsKPKLGPASPE------DINYLAELIKNAKLPVLLLGMRASSPEVTAAIRRLLERTNLPVVETFQA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 244 lggfPGT-DR----QFLGMLGMHGSYTANMAMHHADVIFAVG---ARFDDRVVNGPakfcPNAKIIHIDIDPASISKMIK 315
Cdd:PRK08617 239 ----AGViSReledHFFGRVGLFRNQPGDELLKKADLVITIGydpIEYEPRNWNSE----GDATIIHIDVLPAEIDNYYQ 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 316 ADVPIVGPVESVLSEMLTILKEIGEQPD-KAALDAWWKQIDEwrgdGALFPYDKgDGNLIKPQQVIETLCEVTKGDAFVT 394
Cdd:PRK08617 311 PERELIGDIAATLDLLAEKLDGLSLSPQsLEILEELRAQLEE----LAERPARL-EEGAVHPLRIIRALQDIVTDDTTVT 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 395 SDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPvkIVN 474
Cdd:PRK08617 386 VDVGSHYIWMARYFRSYEPRHLLFSNGMQTLGVALPWAIAAALVRPGKKVVSVSGDGGFLFSAMELETAVRLKLN--IVH 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 475 L--NNGVLGMVRQWQDMAYnGRHSHsyVESLP-DFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMkDRLVFIDIAVDRTE 551
Cdd:PRK08617 464 IiwNDGHYNMVEFQEEMKY-GRSSG--VDFGPvDFVKYAESFGAKGLRVTSPDELEPVLREALAT-DGPVVIDIPVDYSD 539
|
....*.
gi 655281819 552 HVYPMQ 557
Cdd:PRK08617 540 NIKLME 545
|
|
| acolac_catab |
TIGR02418 |
acetolactate synthase, catabolic; Acetolactate synthase (EC 2.2.1.6) combines two molecules of ... |
6-557 |
5.88e-88 |
|
acetolactate synthase, catabolic; Acetolactate synthase (EC 2.2.1.6) combines two molecules of pyruvate to yield 2-acetolactate with the release of CO2. This reaction may be involved in either valine biosynthesis (biosynthetic) or conversion of pyruvate to acetoin and possibly to 2,3-butanediol (catabolic). The biosynthetic type, described by TIGR00118, is also capable of forming acetohydroxybutyrate from pyruvate and 2-oxobutyrate for isoleucine biosynthesis. The family described here, part of the same larger family of thiamine pyrophosphate-dependent enzymes (pfam00205, pfam02776) is the catabolic form, generally found associated with in species with acetolactate decarboxylase and usually found in the same operon. The model may not encompass all catabolic acetolactate synthases, but rather one particular clade in the larger TPP-dependent enzyme family. [Energy metabolism, Fermentation]
Pssm-ID: 131471 [Multi-domain] Cd Length: 539 Bit Score: 282.02 E-value: 5.88e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALfKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:TIGR02418 1 GADLVVDQLENQGVRYVFGIPGAKIDRVFDAL-EDKGIELIVVRHEQNAAFMAQAVGRITGKPGVALVTSGPGCSNLVTG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKDM 165
Cdd:TIGR02418 80 LATANSEGDPVVAIGGQVKRADLLKLTHQSMDNVALFRPITKYSAEVQDPDALSEVVANAFRAAESGKPGAAFVSLPQDV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 166 TNPAEKFEYIYPkkvklrSYSPAVRGHS-GQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGL 244
Cdd:TIGR02418 160 VDSPVSVKAIPA------SYAPKLGAAPdDAIDEVAEAIQNAKLPVLLLGLRASSPETTEAVRRLLKKTQLPVVETFQGA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 245 GgfpGTDR----QFLGMLGMHGSYTANMAMHHADVIFAVGarFDdrvvngPAKFCP-------NAKIIHIDIDPASISKM 313
Cdd:TIGR02418 234 G---AVSReledHFFGRVGLFRNQPGDRLLKQADLVITIG--YD------PIEYEPrnwnsenDATIVHIDVEPAQIDNN 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 314 IKADVPIVGPVESVLSEMLTILKEIGEQPDKAALdawWKQIDEWRGDGALFPYDKGDGNLiKPQQVIETLCEVTKGDAFV 393
Cdd:TIGR02418 303 YQPDLELVGDIASTLDLLAERIPGYELPPDALAI---LEDLKQQREALDRVPATLKQAHL-HPLEIIKAMQAIVTDDVTV 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 394 TSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIV 473
Cdd:TIGR02418 379 TVDMGSHYIWMARYFRSYRARHLLISNGMQTLGVALPWAIGAALVRPNTKVVSVSGDGGFLFSSMELETAVRLKLNIVHI 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 474 NLNNGVLGMVRQWQDMAYngrHSHSYVESLP-DFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMkDRLVFIDIAVDRTEH 552
Cdd:TIGR02418 459 IWNDNGYNMVEFQEEMKY---QRSSGVDFGPiDFVKYAESFGAKGLRVESPDQLEPTLRQAMEV-EGPVVVDIPVDYSDN 534
|
....*
gi 655281819 553 VYPMQ 557
Cdd:TIGR02418 535 PKLMS 539
|
|
| pyruv_oxi_spxB |
TIGR02720 |
pyruvate oxidase; Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an ... |
6-554 |
1.42e-77 |
|
pyruvate oxidase; Members of this family are examples of pyruvate oxidase (EC 1.2.3.3), an enzyme with FAD and TPP as cofactors that catalyzes the reaction pyruvate + phosphate + O2 + H2O = acetyl phosphate + CO2 + H2O2. It should not be confused with pyruvate dehydrogenase [cytochrome] (EC 1.2.2.2) as in E. coli PoxB, although the E. coli enzyme is closely homologous and has pyruvate oxidase as an alternate name. [Energy metabolism, Aerobic]
Pssm-ID: 213733 [Multi-domain] Cd Length: 575 Bit Score: 255.92 E-value: 1.42e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPE-VQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAIT 84
Cdd:TIGR02720 1 ASAAVLKVLEAWGVDHIYGIPGGSFNSTMDALSAERDrIHYIQVRHEEVGALAAAADAKLTGKIGVCFGSAGPGATHLLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 85 GIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSgRPGPVVVDIPKD 164
Cdd:TIGR02720 81 GLYDAKEDHVPVLALVGQVPTTGMNMDTFQEMNENPIYADVAVYNRTAMTAESLPHVIDEAIRRAYA-HNGVAVVTIPVD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 165 M--TNPAEKFEYIYPKKVKLRSYsPAVRGHsgQIRKAAEMLLAAKRPIVYsgGGVILGGGSEALTEIAKSLNLPVTNTLM 242
Cdd:TIGR02720 160 FgwQEIPDNDYYASSVSYQTPLL-PAPDVE--AVTRAVQTLKAAERPVIY--YGIGARKAGEELEALSEKLKIPLISTGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 243 GLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAKfcpNAK-IIHIDIDPASISKMIKADVPIV 321
Cdd:TIGR02720 235 AKGIIEDRYPAYLGSAYRVAQKPANEALFQADLVLFVGNNYPFAEVSKAFK---NTKyFIQIDIDPAKLGKRHHTDIAVL 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 322 GPVESVLSemlTILKEIGEQPDKAALDAWWKQIDEWRGDGALFPyDKGDGNLiKPQQVIETLCEVTKGDAFVTSDVGQHQ 401
Cdd:TIGR02720 312 ADAKKALA---AILAQVEPRESTPWWQANVANVKNWRAYLASLE-DKTEGPL-QAYQVYRAINKIAEDDAIYSIDVGDIN 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 402 MFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLG 481
Cdd:TIGR02720 387 INSNRHLKMTPKNKWITSNLFATMGVGVPGAIAAKLNYPDRQVFNLAGDGAFSMTMQDLLTQVQYHLPVINIVFSNCTYG 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 482 MVRQWQDmaynGRHSHSYVESLP--DFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMK-DRLVFID--IAVDR---TEHV 553
Cdd:TIGR02720 467 FIKDEQE----DTNQPLIGVDFNdaDFAKIAEGVGAVGFRVNKIEQLPAVFEQAKAIKqGKPVLIDakITGDRplpVEKL 542
|
.
gi 655281819 554 Y 554
Cdd:TIGR02720 543 R 543
|
|
| PRK06154 |
PRK06154 |
thiamine pyrophosphate-requiring protein; |
4-533 |
1.21e-76 |
|
thiamine pyrophosphate-requiring protein;
Pssm-ID: 235718 [Multi-domain] Cd Length: 565 Bit Score: 253.20 E-value: 1.21e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALfkepEVQHILVRHEQAATHMADGYARATG--KAGVVLVTSGPGATN 81
Cdd:PRK06154 20 MKVAEAVAEILKEEGVELLFGFPVNELFDAAAAA----GIRPVIARTERVAVHMADGYARATSgeRVGVFAVQYGPGAEN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 82 AITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIgiSRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDI 161
Cdd:PRK06154 96 AFGGVAQAYGDSVPVLFLPTGYPRGSTDVAPNFESLRN--YRHITKWCEQVTLPDEVPELMRRAFTRLRNGRPGPVVLEL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 162 PKDMTN---PAEKFEYIYPKKVKlrsYSPAVRghsgQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVT 238
Cdd:PRK06154 174 PVDVLAeelDELPLDHRPSRRSR---PGADPV----EVVEAAALLLAAERPVIYAGQGVLYAQATPELKELAELLEIPVM 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 239 NTLMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDDRVVNGPAkfcPNAK-IIHIDIDPASISKMIKAD 317
Cdd:PRK06154 247 TTLNGKSAFPEDHPLALGSGGRARPATVAHFLREADVLFGIGCSLTRSYYGLPM---PEGKtIIHSTLDDADLNKDYPID 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 318 VPIVGPVESVLSEMLTILK-EIGEQPDKAA---------LDAWwkqIDEWrgdgalFPYDKGDGNLIKPQQVIETLCE-V 386
Cdd:PRK06154 324 HGLVGDAALVLKQMIEELRrRVGPDRGRAQqvaaeieavRAAW---LAKW------MPKLTSDSTPINPYRVVWELQHaV 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 387 TKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQY 466
Cdd:PRK06154 395 DIKTVIITHDAGSPRDQLSPFYVASRPGSYLGWGKTTQLGYGLGLAMGAKLARPDALVINLWGDAAFGMTGMDFETAVRE 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 467 GLPVKIVNLNNGVLGmvrqwqdmayngrhshSYVESLP-------------DFVKLAEAYGHVGIRITSLKDLKPKLEEA 533
Cdd:PRK06154 475 RIPILTILLNNFSMG----------------GYDKVMPvsttkyratdisgDYAAIARALGGYGERVEDPEMLVPALLRA 538
|
|
| TPP_PYR_POX_like |
cd07035 |
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP ... |
8-163 |
2.30e-76 |
|
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) and related protiens subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. For glyoxylate carboligase, which belongs to this subfamily, but lacks this conserved glutamate, the rate of the initial TPP activation step is reduced but the ensuing steps of the enzymic reaction proceed efficiently. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. This subfamily includes pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. This subfamily also includes the large catalytic subunit of acetohydroxyacid synthase (AHAS). AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate, a precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. Methanococcus jannaschii sulfopyruvate decarboxylase (MjComDE) and phosphonopyruvate decarboxylase (PpyrDc) also belong to this subfamily. PpyrDc is a homotrimeric enzyme having the PP and PYR domains tandemly arranged on the same subunit. It functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. MjComDE is a dodecamer having the PYR and PP domains on different subunits, it has six alpha (PYR/ComD) subunits and six beta (PP/ComE) subunits. MjComDE catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway.
Pssm-ID: 132918 [Multi-domain] Cd Length: 155 Bit Score: 238.59 E-value: 2.30e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 8 EMVVRFLRDEGVKHIYGYPGGALLHVYDALfKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGIA 87
Cdd:cd07035 1 DALVEALKAEGVDHVFGVPGGAILPLLDAL-ARSGIRYILVRHEQGAVGMADGYARATGKPGVVLVTSGPGLTNAVTGLA 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 655281819 88 TAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPK 163
Cdd:cd07035 80 NAYLDSIPLLVITGQRPTAGEGRGAFQEIDQVALFRPITKWAYRVTSPEEIPEALRRAFRIALSGRPGPVALDLPK 155
|
|
| PRK07524 |
PRK07524 |
5-guanidino-2-oxopentanoate decarboxylase; |
4-553 |
5.11e-76 |
|
5-guanidino-2-oxopentanoate decarboxylase;
Pssm-ID: 236041 [Multi-domain] Cd Length: 535 Bit Score: 250.66 E-value: 5.11e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 4 LSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPeVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAI 83
Cdd:PRK07524 2 TTCGEALVRLLEAYGVETVFGIPGVHTVELYRGLAGSG-IRHVTPRHEQGAGFMADGYARVSGKPGVCFIITGPGMTNIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 84 TGIATAYMDSIPMVILSG--QVPSTMVGTDAFQET-DMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK07524 81 TAMGQAYADSIPMLVISSvnRRASLGKGRGKLHELpDQRAMVAGVAAFSHTLMSAEDLPEVLARAFAVFDSARPRPVHIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 161 IPKD-MTNPAEKFeyiyPKKVKLRSYSPAvrGHSGQIRKAAEMLLAAKRPIVysGGGVILGGGSEALTEIAKSLNLPVTN 239
Cdd:PRK07524 161 IPLDvLAAPADHL----LPAPPTRPARPG--PAPAALAQAAERLAAARRPLI--LAGGGALAAAAALRALAERLDAPVAL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 240 TLMGLGGFPgtDRQFLgMLGMHGSYTANMA-MHHADVIFAVG---ARFD-DRVVNGPakFCPNAKIIHIDIDPASISKMI 314
Cdd:PRK07524 233 TINAKGLLP--AGHPL-LLGASQSLPAVRAlIAEADVVLAVGtelGETDyDVYFDGG--FPLPGELIRIDIDPDQLARNY 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 315 KADVPIVGPVESVLSEMLTILKEIGEQPDKAAL--DAWWKQID-EWRGDGALFpydkgdgnlikpQQVIETLCEVTKGDA 391
Cdd:PRK07524 308 PPALALVGDARAALEALLARLPGQAAAADWGAArvAALRQALRaEWDPLTAAQ------------VALLDTILAALPDAI 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 392 FVtSDVGQHQMFAAQYYRFNKPNRWINSG-GLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPV 470
Cdd:PRK07524 376 FV-GDSTQPVYAGNLYFDADAPRRWFNAStGYGTLGYGLPAAIGAALGAPERPVVCLVGDGGLQFTLPELASAVEADLPL 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 471 KIVNLNNGVLGMVRQW---QDMAYNGRHSHSyveslPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAV 547
Cdd:PRK07524 455 IVLLWNNDGYGEIRRYmvaRDIEPVGVDPYT-----PDFIALARAFGCAAERVADLEQLQAALRAAFA-RPGPTLIEVDQ 528
|
....*.
gi 655281819 548 DRTEHV 553
Cdd:PRK07524 529 ACWFAA 534
|
|
| PRK06457 |
PRK06457 |
pyruvate dehydrogenase; Provisional |
5-559 |
1.16e-74 |
|
pyruvate dehydrogenase; Provisional
Pssm-ID: 180570 [Multi-domain] Cd Length: 549 Bit Score: 247.44 E-value: 1.16e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 5 SGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEpEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAIT 84
Cdd:PRK06457 3 SVAEVIIRVLEDNGIQRIYGIPGDSIDPLVDAIRKS-KVKYVQVRHEEGAALAASVEAKITGKPSACMGTSGPGSIHLLN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 85 GIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRpGPVVVDIPKD 164
Cdd:PRK06457 82 GLYDAKMDHAPVIALTGQVESDMIGHDYFQEVNLTKLFDDVAVFNQILINPENAEYIIRRAIREAISKR-GVAHINLPVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 165 MTNPAEKFEYIYPKKVKLRSYSPavrghsgQIRKAAEMLLAAKRPIVYsgGGVILGGGSEALTEIAKSLNLPVTNTLMGL 244
Cdd:PRK06457 161 ILRKSSEYKGSKNTEVGKVKYSI-------DFSRAKELIKESEKPVLL--IGGGTRGLGKEINRFAEKIGAPIIYTLNGK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 245 GGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFDdrVVNgpakFCP-NAKIIHIDIDPASISKMIKADVPIVGP 323
Cdd:PRK06457 232 GILPDLDPKVMGGIGLLGTKPSIEAMDKADLLIMLGTSFP--YVN----FLNkSAKVIQVDIDNSNIGKRLDVDLSYPIP 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 324 VesvlSEMLTIlkEIGEQPDK------AALDAWWKQIDEWRGDGAlfpydkgdgNLIKPQQVIETLCEVTKGDAFVTSDV 397
Cdd:PRK06457 306 V----AEFLNI--DIEEKSDKfyeelkGKKEDWLDSISKQENSLD---------KPMKPQRVAYIVSQKCKKDAVIVTDT 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 398 GQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKL-NFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLN 476
Cdd:PRK06457 371 GNVTMWTARHFRASGEQTFIFSAWLGSMGIGVPGSVGASFaVENKRQVISFVGDGGFTMTMMELITAKKYDLPVKIIIYN 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 477 NGVLGMVRQWQD-MAYngrhSHSYVESL-PDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMKDRLVfIDIAVDRTEHvy 554
Cdd:PRK06457 451 NSKLGMIKFEQEvMGY----PEWGVDLYnPDFTKIAESIGFKGFRLEEPKEAEEIIEEFLNTKGPAV-LDAIVDPNER-- 523
|
....*
gi 655281819 555 PMQIK 559
Cdd:PRK06457 524 PMPPK 528
|
|
| PRK06112 |
PRK06112 |
acetolactate synthase catalytic subunit; Validated |
5-552 |
3.26e-70 |
|
acetolactate synthase catalytic subunit; Validated
Pssm-ID: 235700 [Multi-domain] Cd Length: 578 Bit Score: 236.58 E-value: 3.26e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 5 SGAEMVVRFLRDEGVKHIYGYPggallhVYDALFKEPE---VQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATN 81
Cdd:PRK06112 15 TVAHAIARALKRHGVEQIFGQS------LPSALFLAAEaigIRQIAYRTENAGGAMADGYARVSGKVAVVTAQNGPAATL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 82 AITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDI 161
Cdd:PRK06112 89 LVAPLAEALKASVPIVALVQDVNRDQTDRNAFQELDHIALFQSCTKWVRRVTVAERIDDYVDQAFTAATSGRPGPVVLLL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 162 PKDMtnpaekfeyiypkkVKLRSYSPAVR-----GH---------SGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALT 227
Cdd:PRK06112 169 PADL--------------LTAAAAAPAAPrsnslGHfpldrtvpaPQRLAEAASLLAQAQRPVVVAGGGVHISGASAALA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 228 EIAKSLNLPVTNTLMGLGGFPGTDRQFLGMLGM------HGSYTANMaMHHADVIFAVGARFDDRVVNGPAKFCPNAKII 301
Cdd:PRK06112 235 ALQSLAGLPVATTNMGKGAVDETHPLSLGVVGSlmgprsPGRHLRDL-VREADVVLLVGTRTNQNGTDSWSLYPEQAQYI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 302 HIDIDPASISKMIKAdVPIVGPVESVLSEMLTILKEIG---EQPDKAAL-----DAWWKQIDEWRgdgalfPYDKGDGNL 373
Cdd:PRK06112 314 HIDVDGEEVGRNYEA-LRLVGDARLTLAALTDALRGRDlaaRAGRRAALepaiaAGREAHREDSA------PVALSDASP 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 374 IKPQQVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPN-RWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGS 452
Cdd:PRK06112 387 IRPERIMAELQAVLTGDTIVVADASYSSIWVANFLTARRAGmRFLTPRGLAGLGWGVPMAIGAKVARPGAPVICLVGDGG 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 453 IQMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYnGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEE 532
Cdd:PRK06112 467 FAHVWAELETARRMGVPVTIVVLNNGILGFQKHAETVKF-GTHTDACHFAAVDHAAIARACGCDGVRVEDPAELAQALAA 545
|
570 580
....*....|....*....|
gi 655281819 533 AFAMKDRLVfIDIAVDRTEH 552
Cdd:PRK06112 546 AMAAPGPTL-IEVITDPSAF 564
|
|
| TPP_enzyme_N |
pfam02776 |
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; |
6-165 |
2.64e-69 |
|
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;
Pssm-ID: 460690 [Multi-domain] Cd Length: 169 Bit Score: 220.95 E-value: 2.64e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:pfam02776 1 GAEALADVLKALGVDTVFGVPGGHILPLLDALAKSPGIRYVLTRHEQGAAFAADGYARATGKPGVVLVTSGPGATNALTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQ-ETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKD 164
Cdd:pfam02776 81 LANAYVDSVPLLVISGQRPRSLVGRGALQqELDQLALFRPVTKWAVRVTSADEIPEVLRRAFRAALSGRPGPVYLEIPLD 160
|
.
gi 655281819 165 M 165
Cdd:pfam02776 161 V 161
|
|
| TPP_enzyme_C |
pfam02775 |
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; |
396-545 |
7.57e-67 |
|
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
Pssm-ID: 460689 [Multi-domain] Cd Length: 151 Bit Score: 213.99 E-value: 7.57e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 396 DVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNL 475
Cdd:pfam02775 1 DIGCHQMWAAQYYRFRPPRRYLTSGGLGTMGYGLPAAIGAKLARPDRPVVAIAGDGGFQMNLQELATAVRYNLPITVVVL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 655281819 476 NNGVLGMVRQWQDMAYNGRHSHSYVESL--PDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDI 545
Cdd:pfam02775 81 NNGGYGMTRGQQTPFGGGRYSGPSGKILppVDFAKLAEAYGAKGARVESPEELEEALKEALE-HDGPALIDV 151
|
|
| PRK08327 |
PRK08327 |
thiamine pyrophosphate-requiring protein; |
5-550 |
4.70e-62 |
|
thiamine pyrophosphate-requiring protein;
Pssm-ID: 236243 [Multi-domain] Cd Length: 569 Bit Score: 214.48 E-value: 4.70e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 5 SGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQH-----ILVRHEQAATHMADGYARATGKAGVVLVTSGPGA 79
Cdd:PRK08327 8 TAAELFLELLKELGVDYIFINSGTDYPPIIEAKARARAAGRplpefVICPHEIVAISMAHGYALVTGKPQAVMVHVDVGT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 80 TNAITGIATAYMDSIPMVILSGQVPSTM---VGT-DAF----QET-DMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQ 150
Cdd:PRK08327 88 ANALGGVHNAARSRIPVLVFAGRSPYTEegeLGSrNTRihwtQEMrDQGGLVREYVKWDYEIRRGDQIGEVVARAIQIAM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 151 SGRPGPVVVDIPKDMTnpAEKFEYIypkKVKLRSYSPAVRGHS--GQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTE 228
Cdd:PRK08327 168 SEPKGPVYLTLPREVL--AEEVPEV---KADAGRQMAPAPPAPdpEDIARAAEMLAAAERPVIITWRAGRTAEGFASLRR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 229 IAKSLNLPVTNtlmglggFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVgarfDDRVVNGPAKFCP--NAKIIHIDID 306
Cdd:PRK08327 243 LAEELAIPVVE-------YAGEVVNYPSDHPLHLGPDPRADLAEADLVLVV----DSDVPWIPKKIRPdaDARVIQIDVD 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 307 PaSISKM----IKADVPIVGPVESVLSEMLTILKEIGEQPDK-----------AALDAWWKQIDEWRgdgalfpyDKGDG 371
Cdd:PRK08327 312 P-LKSRIplwgFPCDLCIQADTSTALDQLEERLKSLASAERRrarrrraavreLRIRQEAAKRAEIE--------RLKDR 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 372 NLIKPQQVIETLCEVTKGDAFVTSDVGqhqmFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEG 451
Cdd:PRK08327 383 GPITPAYLSYCLGEVADEYDAIVTEYP----FVPRQARLNKPGSYFGDGSAGGLGWALGAALGAKLATPDRLVIATVGDG 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 452 SIQMNIQELSTCM--QYGLPVKIVNLNNGVLGMVRQWQDMAY-NG--RHSHSYVES----LPDFVKLAEAYGHVGIRITS 522
Cdd:PRK08327 459 SFIFGVPEAAHWVaeRYGLPVLVVVFNNGGWLAVKEAVLEVYpEGyaARKGTFPGTdfdpRPDFAKIAEAFGGYGERVED 538
|
570 580 590
....*....|....*....|....*....|.
gi 655281819 523 LKDLKPKLEEAFA-MKD--RLVFIDIAVDRT 550
Cdd:PRK08327 539 PEELKGALRRALAaVRKgrRSAVLDVIVDRV 569
|
|
| PRK09124 |
PRK09124 |
ubiquinone-dependent pyruvate dehydrogenase; |
7-559 |
4.34e-60 |
|
ubiquinone-dependent pyruvate dehydrogenase;
Pssm-ID: 181661 [Multi-domain] Cd Length: 574 Bit Score: 209.07 E-value: 4.34e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 7 AEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGI 86
Cdd:PRK09124 6 ADYIAKTLEQAGVKRIWGVTGDSLNGLSDSLRRMGTIEWMHTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLHLINGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 87 ATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRpGPVVVDIPKDM- 165
Cdd:PRK09124 86 FDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSNPEQLPRVLAIAMRKAILNR-GVAVVVLPGDVa 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 166 TNPAEKfeyiYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRpiVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGlg 245
Cdd:PRK09124 165 LKPAPE----RATPHWYHAPQPVVTPAEEELRKLAALLNGSSN--ITLLCGSGCAGAHDELVALAETLKAPIVHALRG-- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 246 gfpgtdRQFL--------GMLGMHGSYTANMAMHHADVIFAVGARFDDRvvngpaKFCP-NAKIIHIDIDPASISKMIKA 316
Cdd:PRK09124 237 ------KEHVeydnpydvGMTGLIGFSSGYHAMMNCDTLLMLGTDFPYR------QFYPtDAKIIQIDINPGSLGRRSPV 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 317 DVPIVGPVESVLSEMLTILKEigeQPDKAALDAWWKQIDEWRGDGALFPYDKGDGNLIKPQQVIETLCEVTKGDAFVTSD 396
Cdd:PRK09124 305 DLGLVGDVKATLAALLPLLEE---KTDRKFLDKALEHYRKARKGLDDLAVPSDGGKPIHPQYLARQISEFAADDAIFTCD 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 397 VGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLN 476
Cdd:PRK09124 382 VGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQAAHPGRQVVALSGDGGFSMLMGDFLSLVQLKLPVKIVVFN 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 477 NGVLGMVRqwQDMAYNGrhshsYVE-----SLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVDRTE 551
Cdd:PRK09124 462 NSVLGFVA--MEMKAGG-----YLTdgtdlHNPDFAAIAEACGITGIRVEKASELDGALQRAFA-HDGPALVDVVTAKQE 533
|
....*...
gi 655281819 552 HVYPMQIK 559
Cdd:PRK09124 534 LAMPPQIK 541
|
|
| PRK06546 |
PRK06546 |
pyruvate dehydrogenase; Provisional |
7-548 |
4.45e-60 |
|
pyruvate dehydrogenase; Provisional
Pssm-ID: 180614 [Multi-domain] Cd Length: 578 Bit Score: 209.07 E-value: 4.45e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 7 AEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGI 86
Cdd:PRK06546 6 AEQLVEQLVAAGVKRIYGIVGDSLNPIVDAVRRTGGIEWVHVRHEEAAAFAAAAEAQLTGKLAVCAGSCGPGNLHLINGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 87 ATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAqSGRPGPVVVDIPKDMT 166
Cdd:PRK06546 86 YDAHRSGAPVLAIASHIPSAQIGSGFFQETHPDRLFVECSGYCEMVSSAEQAPRVLHSAIQHA-VAGGGVSVVTLPGDIA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 167 N-PAEKfeyiYPKKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSggGVILGGGSEALTEIAKSLNLPVTNTLMGlG 245
Cdd:PRK06546 165 DePAPE----GFAPSVISPRRPTVVPDPAEVRALADAINEAKKVTLFA--GAGVRGAHAEVLALAEKIKAPVGHSLRG-K 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 246 GFPGTDRQF-LGMLGMHGSYTANMAMHHADVIFAVGARF--DDrvvngpakFCPNAKIIHIDIDPASISKMIKADVPIVG 322
Cdd:PRK06546 238 EWIQYDNPFdVGMSGLLGYGAAHEAMHEADLLILLGTDFpyDQ--------FLPDVRTAQVDIDPEHLGRRTRVDLAVHG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 323 PVESVLSEMLTILKeigEQPDKAALDAWWKQIDEwRGDGALFPYDKGDGNL--IKPQQVIETLCEVTKGDAFVTSDVGQH 400
Cdd:PRK06546 310 DVAETIRALLPLVK---EKTDRRFLDRMLKKHAR-KLEKVVGAYTRKVEKHtpIHPEYVASILDELAADDAVFTVDTGMC 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 401 QMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVL 480
Cdd:PRK06546 386 NVWAARYITPNGRRRVIGSFRHGSMANALPHAIGAQLADPGRQVISMSGDGGLSMLLGELLTVKLYDLPVKVVVFNNSTL 465
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 655281819 481 GMVRqwQDMAYNGRHSHSYVESLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVD 548
Cdd:PRK06546 466 GMVK--LEMLVDGLPDFGTDHPPVDYAAIAAALGIHAVRVEDPKDVRGALREAFA-HPGPALVDVVTD 530
|
|
| PRK05858 |
PRK05858 |
acetolactate synthase; |
6-535 |
4.84e-58 |
|
acetolactate synthase;
Pssm-ID: 235629 [Multi-domain] Cd Length: 542 Bit Score: 203.03 E-value: 4.84e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEpEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:PRK05858 7 AGRLAARRLKAHGVDTMFTLSGGHLFPLYDGAREE-GIRLIDVRHEQTAAFAAEAWAKLTRVPGVAVLTAGPGVTNGMSA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIPKD- 164
Cdd:PRK05858 86 MAAAQFNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVTKFAATAQSAENAGRLVDQALQAAVTPHRGPVFVDFPMDh 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 165 MTNPAEKFEYIYPKKVKLRSYSPAvrghSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGL 244
Cdd:PRK05858 166 AFSMADDDGRPGALTELPAGPTPD----PDALARAAGLLAEAQRPVIMAGTDVWWGHAEAALLRLAEELGIPVLMNGMGR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 245 GGFPGTDRQFLgmlgmhgSYTANMAMHHADVIFAVGARFDDRVvnGPAKFCPNAKIIHIDIDPASISkmikADVPIVGPV 324
Cdd:PRK05858 242 GVVPADHPLAF-------SRARGKALGEADVVLVVGVPMDFRL--GFGVFGGTAQLVHVDDAPPQRA----HHRPVAAGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 325 ESVLSEMLTILKEIGEQPDKAAldAWwkqIDEWR-GDGALFPYDKG----DGNLIKPQQVIETLCEVTKGDAFVTSDVGQ 399
Cdd:PRK05858 309 YGDLSAILSALAGAGGDRTDHQ--GW---IEELRtAETAARARDAAeladDRDPIHPMRVYGELAPLLDRDAIVIGDGGD 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 400 HQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGV 479
Cdd:PRK05858 384 FVSYAGRYIDPYRPGCWLDPGPFGCLGTGPGYALAARLARPSRQVVLLQGDGAFGFSLMDVDTLVRHNLPVVSVIGNNGI 463
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 655281819 480 LGMVRQWQDMAYngrhSHSYVESL-PD--FVKLAEAYGHVGIRITSLKDLKPKLEEAFA 535
Cdd:PRK05858 464 WGLEKHPMEALY----GYDVAADLrPGtrYDEVVRALGGHGELVTVPAELGPALERAFA 518
|
|
| PRK07092 |
PRK07092 |
benzoylformate decarboxylase; Reviewed |
8-548 |
1.07e-57 |
|
benzoylformate decarboxylase; Reviewed
Pssm-ID: 235931 [Multi-domain] Cd Length: 530 Bit Score: 201.72 E-value: 1.07e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 8 EMVVRFLRDEGVKHIYGYPGGALLHVYDALfkePE-VQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGI 86
Cdd:PRK07092 16 DATIDLLRRFGITTVFGNPGSTELPFLRDF---PDdFRYVLGLQEAVVVGMADGYAQATGNAAFVNLHSAAGVGNAMGNL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 87 ATAYMDSIPMVILSGQVPSTMVGTDAF-QETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIP-KD 164
Cdd:PRK07092 93 FTAFKNHTPLVITAGQQARSILPFEPFlAAVQAAELPKPYVKWSIEPARAEDVPAAIARAYHIAMQPPRGPVFVSIPyDD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 165 MTNPAEkfeyiypkKVKLRSYSPAVRGHSGQIRKAAEMLLAAKRP-IVYSGGGVILGGGSEALTeIAKSLNLPVTNTLM- 242
Cdd:PRK07092 173 WDQPAE--------PLPARTVSSAVRPDPAALARLGDALDAARRPaLVVGPAVDRAGAWDDAVR-LAERHRAPVWVAPMs 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 243 GLGGFPGTDRQFLGML-GMHGSYTANMAMHhaDVIFAVGA---RFDdrvVNGPAKFCP-NAKIIHIDIDP--ASISKMIK 315
Cdd:PRK07092 244 GRCSFPEDHPLFAGFLpASREKISALLDGH--DLVLVIGApvfTYH---VEGPGPHLPeGAELVQLTDDPgeAAWAPMGD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 316 AdvpIVGPVESVLSEMLtilkEIGEQPDKAALDAwwkqidewRgdgALFPYDKGDGNLIKPQQVIETLCEVTKGDAFV-- 393
Cdd:PRK07092 319 A---IVGDIRLALRDLL----ALLPPSARPAPPA--------R---PMPPPAPAPGEPLSVAFVLQTLAALRPADAIVve 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 394 --TSDVGQHQmfaaQYYRFNKPNRW--INSGGLgtmGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLP 469
Cdd:PRK07092 381 eaPSTRPAMQ----EHLPMRRQGSFytMASGGL---GYGLPAAVGVALAQPGRRVIGLIGDGSAMYSIQALWSAAQLKLP 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 470 VKIVNLNNGVLGMVRqWQDMAYNGRHSHSYveSLP--DFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMkDRLVFIDIAV 547
Cdd:PRK07092 454 VTFVILNNGRYGALR-WFAPVFGVRDVPGL--DLPglDFVALARGYGCEAVRVSDAAELADALARALAA-DGPVLVEVEV 529
|
.
gi 655281819 548 D 548
Cdd:PRK07092 530 A 530
|
|
| PRK08273 |
PRK08273 |
thiamine pyrophosphate protein; Provisional |
7-548 |
3.54e-54 |
|
thiamine pyrophosphate protein; Provisional
Pssm-ID: 181344 [Multi-domain] Cd Length: 597 Bit Score: 193.59 E-value: 3.54e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 7 AEMVVRFLRDEGVKHIYGYPGGALLHVYDALFK-EPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:PRK08273 6 ADFILERLREWGVRRVFGYPGDGINGLLGALGRaDDKPEFVQARHEEMAAFMAVAHAKFTGEVGVCLATSGPGAIHLLNG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPiVKHSF--MIKHASEIPEVLKKAFYLAQSGRpGPVVVDIPK 163
Cdd:PRK08273 86 LYDAKLDHVPVVAIVGQQARAALGGHYQQEVDLQSLFKD-VAGAFvqMVTVPEQLRHLVDRAVRTALAER-TVTAVILPN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 164 DM-----TNPAEKFEYIyPKKVKLRsySPAVRGHSGQIRKAAEMLLAAKRpiVYSGGGVILGGGSEALTEIAKSLNLPVT 238
Cdd:PRK08273 164 DVqeleyEPPPHAHGTV-HSGVGYT--RPRVVPYDEDLRRAAEVLNAGRK--VAILVGAGALGATDEVIAVAERLGAGVA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 239 NTLMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADVIFAVGARFddrvvngP-AKFCP---NAKIIHIDIDPASISKMI 314
Cdd:PRK08273 239 KALLGKAALPDDLPWVTGSIGLLGTKPSYELMRECDTLLMVGSSF-------PySEFLPkegQARGVQIDIDGRMLGLRY 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 315 KADVPIVGPVESVLSEMLTILKeigEQPDKA-------ALDAWWKQIDEWrgdgALFPYDKgdgnlIKPQQVIETLCEVT 387
Cdd:PRK08273 312 PMEVNLVGDAAETLRALLPLLE---RKKDRSwreriekWVARWWETLEAR----AMVPADP-----VNPQRVFWELSPRL 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 388 KGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMN-IQELSTCMQY 466
Cdd:PRK08273 380 PDNAILTADSGSCANWYARDLRMRRGMMASLSGTLATMGPAVPYAIAAKFAHPDRPVIALVGDGAMQMNgMAELITVAKY 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 467 -----GLPVKIVNLNNGVLGMVrQWQDMAYNGRHSHSYVESLPDF--VKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDR 539
Cdd:PRK08273 460 wrqwsDPRLIVLVLNNRDLNQV-TWEQRVMEGDPKFEASQDLPDVpyARFAELLGLKGIRVDDPEQLGAAWDEALA-ADR 537
|
....*....
gi 655281819 540 LVFIDIAVD 548
Cdd:PRK08273 538 PVVLEVKTD 546
|
|
| TPP_enzyme_M |
pfam00205 |
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a ... |
196-331 |
2.46e-50 |
|
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a 2-fold Rossman fold.
Pssm-ID: 425523 [Multi-domain] Cd Length: 137 Bit Score: 170.05 E-value: 2.46e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 196 IRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLNLPVTNTLMGLGGFPGTDRQFLGMLGMHGSYTANMAMHHADV 275
Cdd:pfam00205 1 IEKAAELLKKAKRPVILAGGGVRRSGASEELRELAEKLGIPVVTTLMGKGAFPEDHPLYLGMLGMHGTPAANEALEEADL 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 655281819 276 IFAVGARFDDRVVNGP-AKFCPNAKIIHIDIDPASISKMIKADVPIVGPVESVLSEM 331
Cdd:pfam00205 81 VLAVGARFDDIRTTGKlPEFAPDAKIIHIDIDPAEIGKNYPVDVPIVGDAKETLEAL 137
|
|
| PRK07064 |
PRK07064 |
thiamine pyrophosphate-binding protein; |
6-537 |
3.07e-50 |
|
thiamine pyrophosphate-binding protein;
Pssm-ID: 180820 [Multi-domain] Cd Length: 544 Bit Score: 181.73 E-value: 3.07e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 6 GAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITG 85
Cdd:PRK07064 5 VGELIAAFLEQCGVKTAFGVISIHNMPILDAIGRRGKIRFVPARGEAGAVNMADAHARVSGGLGVALTSTGTGAGNAAGA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 86 IATAYMDSIPMVILSGQVPSTMVGTDA--FQET-DMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVDIP 162
Cdd:PRK07064 85 LVEALTAGTPLLHITGQIETPYLDQDLgyIHEApDQLTMLRAVSKAAFRVRSAETALATIREAVRVALTAPTGPVSVEIP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 163 KD-----MTNPAEKFeyiyPKKVKLRSYSPAvrghsgQIRKAAEMLLAAKRPIVYsgGGVILGGGSEALTEIAKsLNLPV 237
Cdd:PRK07064 165 IDiqaaeIELPDDLA----PVHVAVPEPDAA------AVAELAERLAAARRPLLW--LGGGARHAGAEVKRLVD-LGFGV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 238 TNTLMGLGGFPGTDRQFLGMLGMHGSYTANMAmhHADVIFAVGARF-----DDRVVNGPakfcpnAKIIHIDIDPASISK 312
Cdd:PRK07064 232 VTSTQGRGVVPEDHPASLGAFNNSAAVEALYK--TCDLLLVVGSRLrgnetLKYSLALP------RPLIRVDADAAADGR 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 313 MIKADVPIVGPVESVLSEMLTILkeigeqPDKAALDAWWKQ-----IDEWRGD--GALFPYdkgdgnlikpQQVIETLCE 385
Cdd:PRK07064 304 GYPNDLFVHGDAARVLARLADRL------EGRLSVDPAFAAdlraaREAAVADlrKGLGPY----------AKLVDALRA 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 386 VTKGDAFVTSDVG-QHQMFAAQYYRFNKPNRWINSGGlGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCM 464
Cdd:PRK07064 368 ALPRDGNWVRDVTiSNSTWGNRLLPIFEPRANVHALG-GGIGQGLAMAIGAALAGPGRKTVGLVGDGGLMLNLGELATAV 446
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 655281819 465 QYGLPVKIVNLNNGVLGMVRQWQDMAYNGRhsHSYVESL-PDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAMK 537
Cdd:PRK07064 447 QENANMVIVLMNDGGYGVIRNIQDAQYGGR--RYYVELHtPDFALLAASLGLPHWRVTSADDFEAVLREALAKE 518
|
|
| PDC1 |
COG3961 |
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate ... |
14-552 |
6.51e-50 |
|
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 443161 [Multi-domain] Cd Length: 545 Bit Score: 180.74 E-value: 6.51e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 14 LRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGkAGVVLVTSGPGATNAITGIATAYMDS 93
Cdd:COG3961 15 LAELGIRHIFGVPGDYNLPFLDAIEAHPGIRWVGCCNELNAGYAADGYARVNG-LGALVTTYGVGELSAINGIAGAYAER 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 94 IPMVILSGqvpstMVGTDAFQetdmigiSRPIVKHSF----------MIKH-------------ASEIPEVLKKAFYLAQ 150
Cdd:COG3961 94 VPVVHIVG-----APGTRAQR-------RGPLLHHTLgdgdfdhflrMFEEvtvaqavltpenaAAEIDRVLAAALREKR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 151 sgrpgPVVVDIPKDMTNpAEkfeyIYPKKVKLRSYSPAVRGHSGQ--IRKAAEMLLAAKRPIVYSGGGVILGGGSEALTE 228
Cdd:COG3961 162 -----PVYIELPRDVAD-AP----IEPPEAPLPLPPPASDPAALAaaVAAAAERLAKAKRPVILAGVEVHRFGLQEELLA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 229 IAKSLNLPVTNTLMGLGGFPGTDRQFLGMlgmhgsYTANM-------AMHHADVIFAVGARFDDRVVNG-PAKFCPnAKI 300
Cdd:COG3961 232 LAEKTGIPVATTLLGKSVLDESHPQFIGT------YAGAAsspevreYVENADCVLCLGVVFTDTNTGGfTAQLDP-ERT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 301 IHIDIDPASISKMIKADVPIvgpvESVLSEMLTILKEIGEQ-------------PDKAAL--DAWWKQIDEWrgdgalfp 365
Cdd:COG3961 305 IDIQPDSVRVGGHIYPGVSL----ADFLEALAELLKKRSAPlpapapppppppaAPDAPLtqDRLWQRLQAF-------- 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 366 ydkgdgnlIKPQQVIetLCEVtkGDAFvtsdvgqhqmFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVA 445
Cdd:COG3961 373 --------LDPGDIV--VADT--GTSL----------FGAADLRLPEGATFIAQPLWGSIGYTLPAALGAALAAPDRRVI 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 446 CVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMVR--QWQDMAYNGrhshsyvesLP--DFVKLAEAYG---HVGI 518
Cdd:COG3961 431 LLVGDGAFQLTAQELSTMLRYGLKPIIFVLNNDGYTIERaiHGPDGPYND---------IAnwDYAKLPEAFGggnALGF 501
|
570 580 590
....*....|....*....|....*....|....
gi 655281819 519 RITSLKDLKPKLEEAFAMKDRLVFIDIAVDRTEH 552
Cdd:COG3961 502 RVTTEGELEEALAAAEANTDRLTLIEVVLDKMDA 535
|
|
| TPP_enzymes |
cd00568 |
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ... |
378-547 |
1.91e-49 |
|
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain] Cd Length: 168 Bit Score: 168.59 E-value: 1.91e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 378 QVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNI 457
Cdd:cd00568 1 RVLAALRAALPEDAIVVNDAGNSAYWAYRYLPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAPDRPVVCIAGDGGFMMTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 458 QELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGRHSHSYVeSLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmK 537
Cdd:cd00568 81 QELATAVRYGLPVIVVVFNNGGYGTIRMHQEAFYGGRVSGTDL-SNPDFAALAEAYGAKGVRVEDPEDLEAALAEALA-A 158
|
170
....*....|
gi 655281819 538 DRLVFIDIAV 547
Cdd:cd00568 159 GGPALIEVKT 168
|
|
| TPP_POX |
cd02014 |
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; ... |
374-551 |
1.57e-46 |
|
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. It requires FAD in addition to TPP and a divalent cation as cofactors.
Pssm-ID: 238972 [Multi-domain] Cd Length: 178 Bit Score: 161.16 E-value: 1.57e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 374 IKPQQVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSI 453
Cdd:cd02014 2 IHPERVAAELNKRAPDDAIFTIDVGNVTVWAARHLRMNGKQRFILSGLLATMGNGLPGAIAAKLAYPDRQVIALSGDGGF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 454 QMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGRHshsYVE-SLPDFVKLAEAYGHVGIRITSLKDLKPKLEE 532
Cdd:cd02014 82 AMLMGDLITAVKYNLPVIVVVFNNSDLGFIKWEQEVMGQPEF---GVDlPNPDFAKIAEAMGIKGIRVEDPDELEAALDE 158
|
170
....*....|....*....
gi 655281819 533 AFAMkDRLVFIDIAVDRTE 551
Cdd:cd02014 159 ALAA-DGPVVIDVVTDPNE 176
|
|
| TPP_PYR_POX |
cd07039 |
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) ... |
7-164 |
2.16e-46 |
|
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. Lactobacillus plantarum POX is a homotetramer (dimer-of-homodimers), having two active sites per homodimer lying between PYR and PP domains of different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate.
Pssm-ID: 132922 [Multi-domain] Cd Length: 164 Bit Score: 160.41 E-value: 2.16e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 7 AEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGI 86
Cdd:cd07039 3 ADVIVETLENWGVKRVYGIPGDSINGLMDALRREGKIEFIQVRHEEAAAFAASAEAKLTGKLGVCLGSSGPGAIHLLNGL 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 655281819 87 ATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRpGPVVVDIPKD 164
Cdd:cd07039 83 YDAKRDRAPVLAIAGQVPTDELGTDYFQEVDLLALFKDVAVYNETVTSPEQLPELLDRAIRTAIAKR-GVAVLILPGD 159
|
|
| TPP_ALS |
cd02010 |
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; ... |
376-551 |
7.53e-44 |
|
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2 molecules of pyruvate to acetolactate and carbon dioxide. ALS does not contain FAD, and requires TPP and a divalent metal cation for activity.
Pssm-ID: 238968 [Multi-domain] Cd Length: 177 Bit Score: 153.98 E-value: 7.53e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 376 PQQVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQM 455
Cdd:cd02010 1 PQRIVHDLRAVMGDDDIVLLDVGAHKIWMARYYRTYAPNTCLISNGLATMGVALPGAIGAKLVYPDRKVVAVSGDGGFMM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 456 NIQELSTCMQYGLPVKIVNLNNGVLGMVRqWQDMAYNGRhsHSYVE-SLPDFVKLAEAYGHVGIRITSLKDLKPKLEEAF 534
Cdd:cd02010 81 NSQELETAVRLKIPLVVLIWNDNGYGLIK-WKQEKEYGR--DSGVDfGNPDFVKYAESFGAKGYRIESADDLLPVLERAL 157
|
170
....*....|....*..
gi 655281819 535 AmKDRLVFIDIAVDRTE 551
Cdd:cd02010 158 A-ADGVHVIDCPVDYSE 173
|
|
| PRK09259 |
PRK09259 |
putative oxalyl-CoA decarboxylase; Validated |
2-535 |
1.50e-39 |
|
putative oxalyl-CoA decarboxylase; Validated
Pssm-ID: 236433 [Multi-domain] Cd Length: 569 Bit Score: 152.06 E-value: 1.50e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 2 ELLSGAEMVVRFLRDEGVKHIYGYPGgalLHVYD-ALFKEPE-VQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGA 79
Cdd:PRK09259 8 QLTDGFHLVIDALKLNGIDTIYGVVG---IPITDlARLAQAEgIRYIGFRHEQSAGNAAAAAGFLTQKPGVCLTVSAPGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 80 TNAITGIATAYMDSIPMVILSGQVPSTMVGTDA--FQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPV 157
Cdd:PRK09259 85 LNGLTALANATTNCFPMIMISGSSEREIVDLQQgdYEELDQLNAAKPFCKAAFRVNRAEDIGIGVARAIRTAVSGRPGGV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 158 VVDIPKDM---TNPAEKfeyiyPKK--VKLRSYSPAVRGHSGQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKS 232
Cdd:PRK09259 165 YLDLPAKVlaqTMDADE-----ALTslVKVVDPAPAQLPAPEAVDRALDLLKKAKRPLIILGKGAAYAQADEQIREFVEK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 233 LNLPVTNTLMGLGGFPGTDRQflgmlgmhgSYTA--NMAMHHADVIFAVGARFDDRVVNGPAK-FCPNAKIIHIDIDPAS 309
Cdd:PRK09259 240 TGIPFLPMSMAKGLLPDTHPQ---------SAAAarSLALANADVVLLVGARLNWLLSHGKGKtWGADKKFIQIDIEPQE 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 310 ISKMIKADVPIVGPVESVLSemlTILKEIGEQPDKAALDaWWKQIDEwrgdgalfpydKGDGNLIKPQQVIET------- 382
Cdd:PRK09259 311 IDSNRPIAAPVVGDIGSVMQ---ALLAGLKQNTFKAPAE-WLDALAE-----------RKEKNAAKMAEKLSTdtqpmnf 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 383 ------LCEVTKG--DAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNfPDQDVACVTGEGSIQ 454
Cdd:PRK09259 376 ynalgaIRDVLKEnpDIYLVNEGANTLDLARNIIDMYKPRHRLDCGTWGVMGIGMGYAIAAAVE-TGKPVVAIEGDSAFG 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 455 MNIQELSTCMQYGLPVKIVNLNNGvlGMVR-------QWQDMA-----YNGRHShsyveslpdfvKLAEAYGHVGIRITS 522
Cdd:PRK09259 455 FSGMEVETICRYNLPVTVVIFNNG--GIYRgddvnlsGAGDPSptvlvHHARYD-----------KMMEAFGGVGYNVTT 521
|
570
....*....|...
gi 655281819 523 LKDLKPKLEEAFA 535
Cdd:PRK09259 522 PDELRHALTEAIA 534
|
|
| TPP_enzyme_PYR |
cd06586 |
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine ... |
14-163 |
9.78e-36 |
|
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine pyrophosphate (TPP) family, pyrimidine (PYR) binding domain; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this group. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. In the case of 2-oxoisovalerate dehydrogenase (2OXO), sulfopyruvate decarboxylase (ComDE), and the E1 component of human pyruvate dehydrogenase complex (E1- PDHc) the PYR and PP domains appear on different subunits. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. For many of these enzymes the active sites lie between PP and PYR domains on different subunits. However, for the homodimeric enzymes 1-deoxy-D-xylulose 5-phosphate synthase (DXS) and Desulfovibrio africanus pyruvate:ferredoxin oxidoreductase (PFOR), each active site lies at the interface of the PYR and PP domains from the same subunit.
Pssm-ID: 132915 [Multi-domain] Cd Length: 154 Bit Score: 130.93 E-value: 9.78e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 14 LRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGkAGVVLVTSGPGATNAITGIATAYMDS 93
Cdd:cd06586 7 LTAWGVRHVFGYPGDEISSLLDALREGDKRIIDTVIHELGAAGAAAGYARAGG-PPVVIVTSGTGLLNAINGLADAAAEH 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 94 IPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGrPGPVVVDIPK 163
Cdd:cd06586 86 LPVVFLIGARGISAQAKQTFQSMFDLGMYRSIPEANISSPSPAELPAGIDHAIRTAYAS-QGPVVVRLPR 154
|
|
| TPP_Xsc_like |
cd02013 |
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of ... |
371-550 |
3.40e-30 |
|
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl phosphate. This enzyme requires TPP and divalent metal ions for activity.
Pssm-ID: 238971 [Multi-domain] Cd Length: 196 Bit Score: 117.23 E-value: 3.40e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 371 GNLIKPQQVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGE 450
Cdd:cd02013 1 GNPMHPRQVLRELEKAMPEDAIVSTDIGNICSVANSYLRFEKPRSFIAPLSFGNCGYALPAIIGAKAAAPDRPVVAIAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 451 GSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGRHSHSYVESlPDFVKLAEAYGHVGIRITSLKDLKPKL 530
Cdd:cd02013 81 GAWGMSMMEIMTAVRHKLPVTAVVFRNRQWGAEKKNQVDFYNNRFVGTELES-ESFAKIAEACGAKGITVDKPEDVGPAL 159
|
170 180
....*....|....*....|..
gi 655281819 531 EEAFAM--KDRLVFIDIAVDRT 550
Cdd:cd02013 160 QKAIAMmaEGKTTVIEIVCDQE 181
|
|
| TPP_BZL_OCoD_HPCL |
cd02004 |
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of ... |
376-548 |
7.90e-27 |
|
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules of benzaldehyde and enabling the Pseudomonas to grow on benzoin as the sole carbon and energy source. OCoD has a role in the detoxification of oxalate, catalyzing the decarboxylation of oxalyl-CoA to formate. 2-HPCL is a peroxisomal enzyme which plays a role in the alpha-oxidation of 3-methyl-branched fatty acids, catalyzing the cleavage of 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. All these enzymes depend on Mg2+ and TPP for activity.
Pssm-ID: 238962 [Multi-domain] Cd Length: 172 Bit Score: 106.85 E-value: 7.90e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 376 PQQVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQM 455
Cdd:cd02004 1 PYRVLHELQEALPDDAIIVSDGGNTMDWARYILRPRKPRHRLDAGTFGTLGVGLGYAIAAALARPDKRVVLVEGDGAFGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 456 NIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGrHSHSYVESLP-DFVKLAEAYGHVGIRITSLKDLKPKLEEAF 534
Cdd:cd02004 81 SGMELETAVRYNLPIVVVVGNNGGWYQGLDGQQLSYGL-GLPVTTLLPDtRYDLVAEAFGGKGELVTTPEELKPALKRAL 159
|
170
....*....|....
gi 655281819 535 AmKDRLVFIDIAVD 548
Cdd:cd02004 160 A-SGKPALINVIID 172
|
|
| TPP_Gcl |
cd02006 |
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins ... |
374-536 |
4.41e-24 |
|
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give tartronic semialdehyde and carbon dioxide. This enzyme requires TPP, magnesium ion and FAD as cofactors.
Pssm-ID: 238964 [Multi-domain] Cd Length: 202 Bit Score: 100.05 E-value: 4.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 374 IKPQQVIETLCEVTKGDAFVTSDVGQHQMFAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSI 453
Cdd:cd02006 8 IKPQRVYEEMNKAFGRDVRYVTTIGLSQIAGAQMLHVYKPRHWINCGQAGPLGWTVPAALGVAAADPDRQVVALSGDYDF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 454 QMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQ---DMAYNGRHSHSYVESLP------DFVKLAEAYGHVGIRITSLK 524
Cdd:cd02006 88 QFMIEELAVGAQHRIPYIHVLVNNAYLGLIRQAQrafDMDYQVNLAFENINSSElggygvDHVKVAEGLGCKAIRVTKPE 167
|
170
....*....|..
gi 655281819 525 DLKPKLEEAFAM 536
Cdd:cd02006 168 ELAAAFEQAKKL 179
|
|
| TPP_BFDC |
cd02002 |
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins ... |
376-547 |
1.86e-22 |
|
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This enzyme is dependent on TPP and a divalent metal cation as cofactors.
Pssm-ID: 238960 [Multi-domain] Cd Length: 178 Bit Score: 94.58 E-value: 1.86e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 376 PQQVIETLCEVTKGDAF-----VTSDVGQHQMFAaqyyrFNKPNRWINSGGlGTMGFGFPAAMGIKLNFPDQDVACVTGE 450
Cdd:cd02002 3 PEYLAAALAAALPEDAIivdeaVTNGLPLRDQLP-----LTRPGSYFTLRG-GGLGWGLPAAVGAALANPDRKVVAIIGD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 451 GSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNGRHSHSYVESL------PDFVKLAEAYGHVGIRITSLK 524
Cdd:cd02002 77 GSFMYTIQALWTAARYGLPVTVVILNNRGYGALRSFLKRVGPEGPGENAPDGLdlldpgIDFAAIAKAFGVEAERVETPE 156
|
170 180
....*....|....*....|...
gi 655281819 525 DLKPKLEEAFAmKDRLVFIDIAV 547
Cdd:cd02002 157 ELDEALREALA-EGGPALIEVVV 178
|
|
| TPP_PDC_IPDC |
cd02005 |
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of ... |
403-549 |
2.91e-20 |
|
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize other 2-oxo acids as substrates. In plants and various plant-associated bacteria, IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway, a tryptophan-dependent biosynthetic route to indole-3-acetaldehyde (IAA). IPDC catalyzes the decarboxylation of IPA to IAA. Both PDC and IPDC depend on TPP and Mg2+ as cofactors.
Pssm-ID: 238963 [Multi-domain] Cd Length: 183 Bit Score: 88.36 E-value: 2.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 403 FAAQYYRFNKPNRWINSGGLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGM 482
Cdd:cd02005 30 FGALDLKLPKGTRFISQPLWGSIGYSVPAALGAALAAPDRRVILLVGDGSFQMTVQELSTMIRYGLNPIIFLINNDGYTI 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 655281819 483 VRQWQDMAYngrhshSYVESLP-DFVKLAEAYG----HVGIRITSLKDLKPKLEEAFAMKDRLVFIDIAVDR 549
Cdd:cd02005 110 ERAIHGPEA------SYNDIANwNYTKLPEVFGggggGLSFRVKTEGELDEALKDALFNRDKLSLIEVILPK 175
|
|
| TPP_PYR_PDC_IPDC_like |
cd07038 |
Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase ... |
14-155 |
8.16e-19 |
|
Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. Also belonging to this group is Mycobacterium tuberculosis alpha-keto acid decarboxylase (MtKDC) which participates in amino acid degradation via the Ehrlich pathway, and Lactococcus lactis branched-chain keto acid decarboxylase (KdcA) an enzyme identified as being involved in cheese ripening, which exhibits a very broad substrate range in the decarboxylation and carboligation reactions.
Pssm-ID: 132921 [Multi-domain] Cd Length: 162 Bit Score: 83.70 E-value: 8.16e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 14 LRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGkAGVVLVTSGPGATNAITGIATAYMDS 93
Cdd:cd07038 7 LKQLGVKHVFGVPGDYNLPLLDAIEENPGLRWVGNCNELNAGYAADGYARVKG-LGALVTTYGVGELSALNGIAGAYAEH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 94 IPMVILSGqVPST-----------MVGT---DAFQEtdmigISRPIVKHSFMIKH----ASEIPEVLKKAFylaQSGRPG 155
Cdd:cd07038 86 VPVVHIVG-APSTkaqasglllhhTLGDgdfDVFLK-----MFEEITCAAARLTDpenaAEEIDRVLRTAL---RESRPV 156
|
|
| TPP_PYR_MenD |
cd07037 |
Pyrimidine (PYR) binding domain of ... |
10-162 |
2.66e-15 |
|
Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase (MenD) and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate (SEPHCHC) synthase (MenD) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. Escherichia coli MenD (EcMenD) is a homotetramer (dimer-of-homodimers), having two active sites per homodimer lying between PYR and PP domains of different subunits. EcMenD catalyzes a Stetter-like conjugate addition of alpha-ketoglutarate to isochorismate, leading to the formation of SEPHCHC and carbon dioxide, this addition is the first committed step in the biosynthesis of vitamin K2 (menaquinone).
Pssm-ID: 132920 [Multi-domain] Cd Length: 162 Bit Score: 73.69 E-value: 2.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 10 VVRFLRDEGVKHIYGYPG---GALLHvydALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAITGI 86
Cdd:cd07037 3 LVEELKRLGVRDVVISPGsrsAPLAL---AAAEHPEFRLHVRVDERSAAFFALGLAKASGRPVAVVCTSGTAVANLLPAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 87 ATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSF------MIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:cd07037 80 VEAYYSGVPLLVLTADRPPELRGTGANQTIDQVGLFGDYVRWSVdlpppeDDDDLWYLLRLANRAVLEALSAPPGPVHLN 159
|
..
gi 655281819 161 IP 162
Cdd:cd07037 160 LP 161
|
|
| PRK12474 |
PRK12474 |
hypothetical protein; Provisional |
1-208 |
2.76e-15 |
|
hypothetical protein; Provisional
Pssm-ID: 139002 [Multi-domain] Cd Length: 518 Bit Score: 78.76 E-value: 2.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 1 MELLSGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGAT 80
Cdd:PRK12474 2 GQTMNGADSVVDTLLNCGVEVCFANPGTSEMHFVAALDRVPRMRPVLCLFEGVVTGAADGYGRIAGKPAVTLLHLGPGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 81 NAITGIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIVKHSFMIKHASEIPEVLKKAFYLAQSGRPGPVVVD 160
Cdd:PRK12474 82 NGLANLHNARRAASPIVNIVGDHAVEHLQYDAPLTSDIDGFARPVSRWVHRSASAGAVDSDVARAVQAAQSAPGGIATLI 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 655281819 161 IPKDMT-NPAEKfeyiypKKVKLRSYSPAvRGHSGQIRKAAEMLLAAKR 208
Cdd:PRK12474 162 MPADVAwNEAAY------AAQPLRGIGPA-PVAAETVERIAALLRNGKK 203
|
|
| TPP_IolD |
cd02003 |
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins ... |
421-548 |
3.01e-14 |
|
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism.
Pssm-ID: 238961 [Multi-domain] Cd Length: 205 Bit Score: 71.57 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 421 GLGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQdMAYNG------- 493
Cdd:cd02003 46 GYSCMGYEIAAGLGAKLAKPDREVYVLVGDGSYLMLHSEIVTAVQEGLKIIIVLFDNHGFGCINNLQ-ESTGSgsfgtef 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 655281819 494 RHSHSYVESLP------DFVKLAEAYGHVGIRITSLKDLKPKLEEAFAmKDRLVFIDIAVD 548
Cdd:cd02003 125 RDRDQESGQLDgallpvDFAANARSLGARVEKVKTIEELKAALAKAKA-SDRTTVIVIKTD 184
|
|
| PRK07586 |
PRK07586 |
acetolactate synthase large subunit; |
5-535 |
5.42e-13 |
|
acetolactate synthase large subunit;
Pssm-ID: 236063 [Multi-domain] Cd Length: 514 Bit Score: 71.41 E-value: 5.42e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 5 SGAEMVVRFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGKAGVVLVTSGPGATNAIT 84
Cdd:PRK07586 2 NGAESLVRTLVDGGVDVCFANPGTSEMHFVAALDRVPGMRCVLGLFEGVATGAADGYARMAGKPAATLLHLGPGLANGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 85 GIATAYMDSIPMVILSGQVPSTMVGTDAFQETDMIGISRPIvkHSFM--IKHASEIPEVLKKAFYLAQSGrPGPVVVDI- 161
Cdd:PRK07586 82 NLHNARRARTPIVNIVGDHATYHRKYDAPLTSDIEALARPV--SGWVrrSESAADVAADAAAAVAAARGA-PGQVATLIl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 162 PKD-MTNPAEKfeyiyPKKVKLRSYSPAVRGHsgQIRKAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKS----LNLP 236
Cdd:PRK07586 159 PADvAWSEGGP-----PAPPPPAPAPAAVDPA--AVEAAAAALRSGEPTVLLLGGRALRERGLAAAARIAAAtgarLLAE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 237 VTNTLMGLG-GFPGTDRqfLGmlgmhgsYTANMAMH---HADVIFAVGAR-------FDDRvvngPAKFCPNAKIIHIDI 305
Cdd:PRK07586 232 TFPARMERGaGRPAVER--LP-------YFAEQALAqlaGVRHLVLVGAKapvaffaYPGK----PSRLVPEGCEVHTLA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 306 DPASiskmikadvpivgPVESVLsEMLtiLKEIGEQPDKAALDAWwkqIDEWRGDGALFPYDKGD--GNLIkPQQVIetL 383
Cdd:PRK07586 299 GPGE-------------DAAAAL-EAL--ADALGAKPAAPPLAAP---ARPPLPTGALTPEAIAQviAALL-PENAI--V 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 384 CE--VTKGDAFVTSDVGqhqmfAAqyyrfnkPNRWINSGGlGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELS 461
Cdd:PRK07586 357 VDesITSGRGFFPATAG-----AA-------PHDWLTLTG-GAIGQGLPLATGAAVACPDRKVLALQGDGSAMYTIQALW 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 462 TCMQYGLPVKIVNLNN-------------GVLGMVRQWQDMAYNGRhshsyveslP--DFVKLAEAYGHVGIRITSLKDL 526
Cdd:PRK07586 424 TQARENLDVTTVIFANrayailrgelarvGAGNPGPRALDMLDLDD---------PdlDWVALAEGMGVPARRVTTAEEF 494
|
....*....
gi 655281819 527 KPKLEEAFA 535
Cdd:PRK07586 495 ADALAAALA 503
|
|
| PLN02573 |
PLN02573 |
pyruvate decarboxylase |
12-549 |
1.36e-12 |
|
pyruvate decarboxylase
Pssm-ID: 215311 [Multi-domain] Cd Length: 578 Bit Score: 70.50 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 12 RFLRDEGVKHIYGYPGGALLHVYDALFKEPEVQHILVRHEQAATHMADGYARATGkAGVVLVTSGPGATNAITGIATAYM 91
Cdd:PLN02573 24 RRLVEIGVTDVFSVPGDFNLTLLDHLIAEPGLNLIGCCNELNAGYAADGYARARG-VGACVVTFTVGGLSVLNAIAGAYS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 92 DSIPMVILSGQVPSTMVGTD-AFQETdmIGIS---------RPIVKHSFMIKHASEIPEVLKKAFYLAQsGRPGPVVVDI 161
Cdd:PLN02573 103 ENLPVICIVGGPNSNDYGTNrILHHT--IGLPdfsqelrcfQTVTCYQAVINNLEDAHELIDTAISTAL-KESKPVYISV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 162 P---KDMTNPAEKFE----YIYPKKVKLRSYSPAVRGhsgqirkAAEMLLAAKRPIVYSGGGVILGGGSEALTEIAKSLN 234
Cdd:PLN02573 180 ScnlAAIPHPTFSREpvpfFLTPRLSNKMSLEAAVEA-------AAEFLNKAVKPVLVGGPKLRVAKACKAFVELADASG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 235 LPVTNTLMGLGGFPGTDRQFLGML--GMHGSYTANMaMHHADVIFAVGARFDDRVVNGPAKFCPNAKIIHIDIDPASISK 312
Cdd:PLN02573 253 YPVAVMPSAKGLVPEHHPHFIGTYwgAVSTPFCAEI-VESADAYLFAGPIFNDYSSVGYSLLLKKEKAIIVQPDRVTIGN 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 313 MikadvPIVGPVesVLSEMLTIL-KEIgeQPDKAALDAwWKQIdeWRGDGALFPYDKGD----GNLIKPQQvietlcEVT 387
Cdd:PLN02573 332 G-----PAFGCV--LMKDFLEALaKRV--KKNTTAYEN-YKRI--FVPEGEPLKSEPGEplrvNVLFKHIQ------KML 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 388 KGDAFVTSDVGqhqmfaaqyyrfnkpNRWINSGGL--------------GTMGFGFPAAMGIKLNFPDQDV-ACVtGEGS 452
Cdd:PLN02573 394 SGDTAVIAETG---------------DSWFNCQKLklpegcgyefqmqyGSIGWSVGATLGYAQAAPDKRViACI-GDGS 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 453 IQMNIQELSTCMQYGLPVKIVNLNNGVLGMVRQWQDMAYNgrhshsyVESLPDFVKLAEAYgHVG------IRITSLKDL 526
Cdd:PLN02573 458 FQVTAQDVSTMIRCGQKSIIFLINNGGYTIEVEIHDGPYN-------VIKNWNYTGLVDAI-HNGegkcwtAKVRTEEEL 529
|
570 580
....*....|....*....|....
gi 655281819 527 KPKLEEAF-AMKDRLVFIDIAVDR 549
Cdd:PLN02573 530 IEAIATATgEKKDCLCFIEVIVHK 553
|
|
| TPP_PpyrDC |
cd03371 |
Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of ... |
423-552 |
1.70e-06 |
|
Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. These proteins require TPP and divalent metal cation cofactors.
Pssm-ID: 239468 [Multi-domain] Cd Length: 188 Bit Score: 48.85 E-value: 1.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 423 GTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELSTCMQYGLP--VKIVnLNNGVLGMVrqwqdmayNGRHSHSYV 500
Cdd:cd03371 48 GSMGHASQIALGIALARPDRKVVCIDGDGAALMHMGGLATIGGLAPAnlIHIV-LNNGAHDSV--------GGQPTVSFD 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 655281819 501 ESLPDFVKlAEAYGHVgIRITSLKDLKPKLEEAFAMkDRLVFIDIAVDRTEH 552
Cdd:cd03371 119 VSLPAIAK-ACGYRAV-YEVPSLEELVAALAKALAA-DGPAFIEVKVRPGSR 167
|
|
| TPP_ComE |
cd03372 |
Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins ... |
378-548 |
3.89e-04 |
|
Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits, which catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway. ComDE requires TPP and divalent metal cation cofactors.
Pssm-ID: 239469 [Multi-domain] Cd Length: 179 Bit Score: 41.50 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 378 QVIETLCEVTKgDAFVTSDVG--QHQMFAAQyyrfnkpNRWINSGGLGTMGFGFPAAMGIKLNFPDQdVACVTGEGSIQM 455
Cdd:cd03372 3 DAIKTLIADLK-DELVVSNIGfpSKELYAAG-------DRPLNFYMLGSMGLASSIGLGLALAQPRK-VIVIDGDGSLLM 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 456 NIQELSTCMQYGLP-VKIVNLNNGVL---GMVRQwqdmayngrHSHSYVeslpDFVKLAEAYG-HVGIRITSLKDLKPKL 530
Cdd:cd03372 74 NLGALATIAAEKPKnLIIVVLDNGAYgstGNQPT---------HAGKKT----DLEAVAKACGlDNVATVASEEAFEKAV 140
|
170
....*....|....*...
gi 655281819 531 EEAfamKDRLVFIDIAVD 548
Cdd:cd03372 141 EQA---LDGPSFIHVKIK 155
|
|
| PRK06163 |
PRK06163 |
hypothetical protein; Provisional |
422-462 |
4.50e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 235721 [Multi-domain] Cd Length: 202 Bit Score: 38.66 E-value: 4.50e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 655281819 422 LGTMGFGFPAAMGIKLNFPDQDVACVTGEGSIQMNIQELST 462
Cdd:PRK06163 56 LGSMGLAFPIALGVALAQPKRRVIALEGDGSLLMQLGALGT 96
|
|
| TPP_ComE_PpyrDC |
cd02001 |
Thiamine pyrophosphate (TPP) family, ComE and PpyrDC subfamily, TPP-binding module; composed ... |
422-535 |
5.28e-03 |
|
Thiamine pyrophosphate (TPP) family, ComE and PpyrDC subfamily, TPP-binding module; composed of proteins similar to sulfopyruvate decarboxylase beta subunit (ComE) and phosphonopyruvate decarboxylase (Ppyr decarboxylase). Methanococcus jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits which, catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway. Ppyr decarboxylase is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. Ppyr decarboxylase and ComDE require TPP and divalent metal cation cofactors.
Pssm-ID: 238959 [Multi-domain] Cd Length: 157 Bit Score: 37.85 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655281819 422 LGTMGFGFPAAMGIKLNFPDQdVACVTGEGSIQMNIQELSTCMQY-GLPVKIVNLNNGVLGmvrqwqdmAYNGRHSHSYV 500
Cdd:cd02001 41 LGSMGLAGSIGLGLALGLSRK-VIVVDGDGSLLMNPGVLLTAGEFtPLNLILVVLDNRAYG--------STGGQPTPSSN 111
|
90 100 110
....*....|....*....|....*....|....*
gi 655281819 501 ESLPdfvKLAEAYGHVGIRITSLKDLKPKLEEAFA 535
Cdd:cd02001 112 VNLE---AWAAACGYLVLSAPLLGGLGSEFAGLLA 143
|
|
| |
