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Conserved domains on  [gi|655376227|ref|WP_028781506|]
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MULTISPECIES: MurR/RpiR family transcriptional regulator [Shewanella]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11485311)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

Gene Ontology:  GO:0006355|GO:0006351|GO:0003677|GO:0003700|GO:0097367

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 1-284 0e+00

DNA-binding transcriptional regulator HexR; Provisional


:

Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 594.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY 80
Cdd:PRK11302   1 MNMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  81 VSRHVEEDDTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVLCF 160
Cdd:PRK11302  81 VNRNVEEDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 161 DDVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITARHSPLSQECTLPVTMEVPEDTDMYLPMASR 240
Cdd:PRK11302 161 DDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 655376227 241 LAQLVIIDVLATGFTLRRGPRFRESLKRVKEVLKESRIDKSEPL 284
Cdd:PRK11302 241 IAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDLLN 284
 
Name Accession Description Interval E-value
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 1-284 0e+00

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 594.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY 80
Cdd:PRK11302   1 MNMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  81 VSRHVEEDDTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVLCF 160
Cdd:PRK11302  81 VNRNVEEDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 161 DDVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITARHSPLSQECTLPVTMEVPEDTDMYLPMASR 240
Cdd:PRK11302 161 DDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 655376227 241 LAQLVIIDVLATGFTLRRGPRFRESLKRVKEVLKESRIDKSEPL 284
Cdd:PRK11302 241 IAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDLLN 284
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-278 2.30e-97

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 287.59  E-value: 2.30e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY 80
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  81 VSRH--VEEDDTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVL 158
Cdd:COG1737   85 YERLrrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 159 CFD-DVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITA-RHSPLSQECTLPVTMEVPEDTDMYLP 236
Cdd:COG1737  165 LLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDsPLSPLAKLADVVLYVPSEEPTLRSSA 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 655376227 237 MASRLAQLVIIDVLATGFTLRRGPRFRESLKRVKEVLKESRI 278
Cdd:COG1737  245 FSSRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELRE 286
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 117-253 2.95e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 144.29  E-value: 2.95e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 117 AINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVLCFDDVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIAR 196
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 655376227 197 LARENGAAVIGITAR-HSPLSQECTLPVTMEVPEDTDMYLPMASRLAQLVIIDVLATG 253
Cdd:cd05013   82 IAKERGAKVIAITDSaNSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 1-77 2.65e-30

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 108.96  E-value: 2.65e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 655376227    1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANG 77
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELANS 77
 
Name Accession Description Interval E-value
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 1-284 0e+00

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 594.28  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY 80
Cdd:PRK11302   1 MNMLEKIQSRLEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  81 VSRHVEEDDTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVLCF 160
Cdd:PRK11302  81 VNRNVEEDDSVEAYTGKIFESAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAHDAQNKFFRFNVPVVYF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 161 DDVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITARHSPLSQECTLPVTMEVPEDTDMYLPMASR 240
Cdd:PRK11302 161 DDIVMQRMSCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 655376227 241 LAQLVIIDVLATGFTLRRGPRFRESLKRVKEVLKESRIDKSEPL 284
Cdd:PRK11302 241 IAQLTVIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDLLN 284
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 1-278 2.30e-97

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 287.59  E-value: 2.30e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPY 80
Cdd:COG1737    5 MSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  81 VSRH--VEEDDTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVL 158
Cdd:COG1737   85 YERLrrLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 159 CFD-DVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITA-RHSPLSQECTLPVTMEVPEDTDMYLP 236
Cdd:COG1737  165 LLDgDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDsPLSPLAKLADVVLYVPSEEPTLRSSA 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 655376227 237 MASRLAQLVIIDVLATGFTLRRGPRFRESLKRVKEVLKESRI 278
Cdd:COG1737  245 FSSRVAQLALIDALAAAVAQRDGDKARERLERTEALLSELRE 286
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
4-258 4.10e-65

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 214.78  E-value: 4.10e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   4 LEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANGTPYVSR 83
Cdd:PRK14101 344 FERIRQMRDALTPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSHS 423

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  84 HVEEDDTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVLCFDDV 163
Cdd:PRK14101 424 QVHLGDTATDFGAKVLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDL 503

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 164 LMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITARHSPLSQECTLPVTMEVPEDTDMYLPMASRLAQ 243
Cdd:PRK14101 504 YMQAASAALLGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILH 583

                        250
                 ....*....|....*
gi 655376227 244 LVIIDVLATGFTLRR 258
Cdd:PRK14101 584 LVMIDILAVGVAIRR 598
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
11-250 1.01e-45

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 155.69  E-value: 1.01e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  11 LPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSlaNGTPYVSRHVE--ED 88
Cdd:PRK11337  23 QEGLTPLESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEDY--FSQSEQVLHSElsFD 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  89 DTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVLCFDDVLMQRM 168
Cdd:PRK11337 101 DAPQDVVNKVFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHIMLM 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 169 SCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGIT-ARHSPLSQECTLPVTMEVPEDTDMYLPMASRLAQLVII 247
Cdd:PRK11337 181 SAALLQEGDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITnSYHSPIAKLADYVICSTAQGSPLLGENAAARIAQLNIL 260


                 ...
gi 655376227 248 DVL 250
Cdd:PRK11337 261 DAF 263
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 117-253 2.95e-43

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 144.29  E-value: 2.95e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 117 AINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRFNVPVLCFDDVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIAR 196
Cdd:cd05013    2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 655376227 197 LARENGAAVIGITAR-HSPLSQECTLPVTMEVPEDTDMYLPMASRLAQLVIIDVLATG 253
Cdd:cd05013   82 IAKERGAKVIAITDSaNSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 1-77 2.65e-30

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 108.96  E-value: 2.65e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 655376227    1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLANG 77
Cdd:pfam01418   1 MGLLEKIQSRYSKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELANS 77
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 124-252 3.05e-23

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 91.98  E-value: 3.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  124 ILTQAKKISFFGLGASASVAHDAQNKFFRFNV-PVLCFDDVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENG 202
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYkVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 655376227  203 AAVIGITAR-HSPLSQECTLPVTMEVPEDTdMYLPMASRLAQLVIIDVLAT 252
Cdd:pfam01380  81 AKIIAITDSpGSPLAREADHVLYINAGPET-GVASTKSITAQLAALDALAV 130
PRK15482 PRK15482
HTH-type transcriptional regulator MurR;
1-254 5.64e-22

HTH-type transcriptional regulator MurR;


Pssm-ID: 185379 [Multi-domain]  Cd Length: 285  Bit Score: 92.84  E-value: 5.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   1 MNTLEKVQKNLPHFSKSERKVAEVILASPQTAIHSSIATLAKMADVSEPTVNRFCRRLDTKGFPDFKLHLAQSLA----- 75
Cdd:PRK15482   1 MLYLTKIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSasrek 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227  76 -NGTP-YVSRHVEEDDTPESYTTKIFESSMASLDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAHDAQNKFFRF 153
Cdd:PRK15482  81 tNATAlHLHSSITSDDSLEVIARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGGSALVGRDLSFKLMKI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 154 NVPVLCFDDVLMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITA-RHSPLSQECTLPVTMEVPEDTD 232
Cdd:PRK15482 161 GYRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSlADSPLRRLAHFTLDTVSGETEW 240

                        250       260
                 ....*....|....*....|..
gi 655376227 233 MYLPMASRLAQLVIIDVLATGF 254
Cdd:PRK15482 241 RSSSMSTRTAQNSVTDLLFVGL 262
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 175-251 1.41e-12

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 63.33  E-value: 1.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 175 EGDVVVLISHTGRTKSLIDIARLARENGAAVIGITA-RHSPLSQECTLPVTMEVPEDTDMY--LPMASRLAQLVIIDVLA 251
Cdd:cd05014   47 PGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGnPNSTLAKLSDVVLDLPVEEEACPLglAPTTSTTAMLALGDALA 126
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 106-232 1.52e-11

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 61.82  E-value: 1.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 106 LDTARQSIDTTAINKAVDILTQAKKISFFGLGASASVAhdaqnKFF--R-----FNVPVLcFDDVlmqrmsCINSDEGDV 178
Cdd:cd05005   11 IENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVA-----KAFamRlmhlgLNVYVV-GETT------TPAIGPGDL 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 655376227 179 VVLISHTGRTKSLIDIARLARENGAAVIGITA-RHSPLSQECTlpVTMEVPEDTD 232
Cdd:cd05005   79 LIAISGSGETSSVVNAAEKAKKAGAKVVLITSnPDSPLAKLAD--VVVVIPAATK 131
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 175-255 2.58e-10

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 59.99  E-value: 2.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 175 EGDVVVLISHTGRTKSLIDIARLARENGAAVIGITAR-HSPLSQECTLPVTMEVPEDTDMY--LPMASRLAQLVIIDVLA 251
Cdd:COG0794   91 PGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNpDSTLARAADVVLDLPVEREACPLnlAPTTSTTATLALGDALA 170

                         90
                 ....*....|
gi 655376227 252 ------TGFT 255
Cdd:COG0794  171 valleaRGFT 180
SIS_GmhA cd05006
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ...
 109-211 3.48e-09

Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).


Pssm-ID: 240139 [Multi-domain]  Cd Length: 177  Bit Score: 54.82  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 109 ARQSIDTTAINKAVDILTQA----KKISFFGLGASASVA-HDAQN-----KFFRFNVPVLCF-DDVLMqrMSCINSD--- 174
Cdd:cd05006   10 ALLELLAEAIEQAAQLLAEAllngGKILICGNGGSAADAqHFAAElvkrfEKERPGLPAIALtTDTSI--LTAIANDygy 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 655376227 175 -------------EGDVVVLISHTGRTKSLIDIARLARENGAAVIGITAR 211
Cdd:cd05006   88 eevfsrqvealgqPGDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGR 137
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 99-209 8.06e-09

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 52.98  E-value: 8.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227   99 FESSMASLDTARQSiDTTAINKAVDILTQA----KKISFFGLGASASVAHDAQN---KFFRFNvPVLCFDDVLMQRMSCI 171
Cdd:pfam13580   3 LDEVRALLERVVET-QADAIEKAADLIAASlangGKVYAFGTGHSAAPAEELFAragGLAGFE-PILLPALALHTDASAT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 655376227  172 NS-------------------DEGDVVVLISHTGRTKSLIDIARLARENGAAVIGIT 209
Cdd:pfam13580  81 IStalerdegyarqilalypgRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 131-210 1.45e-08

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 51.22  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 131 ISFFGLGASASVAHDAQNKFFRFN-VPVLCFDDV-LMQRMSCINSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGI 208
Cdd:cd04795    1 IFVIGIGGSGAIAAYFALELLELTgIEVVALIATeLEHASLLSLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                 ..
gi 655376227 209 TA 210
Cdd:cd04795   81 TD 82
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 174-237 4.93e-08

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 50.27  E-value: 4.93e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 655376227 174 DEGDVVVLISHTGRTKSLIDIARLARENGAAVIGIT-ARHSPLSQECTLPVTMEVPEDTDMYLPM 237
Cdd:cd05710   46 TEKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTdDEDSPLAKLADYVIVYGFEIDAVEEKYL 110
PRK02947 PRK02947
sugar isomerase domain-containing protein;
175-213 3.50e-07

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 50.25  E-value: 3.50e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 655376227 175 EGDVVVLISHTGRTKSLIDIARLARENGAAVIGITAR-HS 213
Cdd:PRK02947 106 PGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTSLaYS 145
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 174-225 6.72e-07

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 47.49  E-value: 6.72e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 655376227 174 DEGDVVVLISHTGRTKSLIDIARLARENGAAVIGIT-ARHSPLSQECTLPVTM 225
Cdd:cd05008   45 DEDTLVIAISQSGETADTLAALRLAKEKGAKTVAITnVVGSTLAREADYVLYL 97
murQ PRK05441
N-acetylmuramic acid-6-phosphate etherase; Reviewed
 175-229 1.25e-06

N-acetylmuramic acid-6-phosphate etherase; Reviewed


Pssm-ID: 235467 [Multi-domain]  Cd Length: 299  Bit Score: 48.63  E-value: 1.25e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 655376227 175 EGDVVVLISHTGRTKSLIDIARLARENGAAVIGITA-RHSPLSQECTLPVTMEV-PE 229
Cdd:PRK05441 131 AKDVVVGIAASGRTPYVIGALEYARERGALTIGISCnPGSPLSKEADIAIEVVVgPE 187
gutQ PRK11543
arabinose-5-phosphate isomerase GutQ;
174-259 3.77e-05

arabinose-5-phosphate isomerase GutQ;


Pssm-ID: 183186 [Multi-domain]  Cd Length: 321  Bit Score: 44.37  E-value: 3.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 174 DEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITAR-HSPLSQ--ECTLPVTMEvPEDTDMYL-PMASRLAQLVIIDV 249
Cdd:PRK11543  88 ESRDVMLFISYSGGAKELDLIIPRLEDKSIALLAMTGKpTSPLGLaaKAVLDISVE-REACPMHLaPTSSTVNTLMMGDA 166

                         90
                 ....*....|
gi 655376227 250 LATGFTLRRG 259
Cdd:PRK11543 167 LAMAVMQARG 176
MurQ COG2103
N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis] ...
 175-229 4.78e-05

N-acetylmuramic acid 6-phosphate (MurNAc-6-P) etherase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441706 [Multi-domain]  Cd Length: 301  Bit Score: 43.93  E-value: 4.78e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 655376227 175 EGDVVVLISHTGRTKSLIDIARLARENGAAVIGITA-RHSPLSQECTLPVTMEV-PE 229
Cdd:COG2103  132 PGDVVVGIAASGRTPYVIGALEYARARGALTVAIACnPGSPLSAAADIAIELVTgPE 188
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 174-245 1.18e-04

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 42.96  E-value: 1.18e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 655376227 174 DEGDVVVLISHTGRTKSLIDIARLARENGAAVIGITAR-HSPLSQECTLPVTMEVPED-----TDMYLPMASRLAQLV 245
Cdd:COG2222   81 LEGTLVVAISRSGNSPEVVAALELAKARGARTLAITNNpDSPLAEAADRVLPLPAGPEksvaaTKSFTTMLLALLALL 158
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 171-229 1.98e-03

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 39.04  E-value: 1.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 655376227 171 INSDEGDVVVLISHTGRTKSLIDIARLARENGAAVIGIT-ARHSPLSQECTLPVTMEV-PE 229
Cdd:cd05007  114 INLTERDVVIGIAASGRTPYVLGALRYARARGALTIGIAcNPGSPLLQLADIAIALITgPE 174
PRK08674 PRK08674
bifunctional phosphoglucose/phosphomannose isomerase; Validated
 124-284 4.13e-03

bifunctional phosphoglucose/phosphomannose isomerase; Validated


Pssm-ID: 181536 [Multi-domain]  Cd Length: 337  Bit Score: 38.04  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 124 ILTQAKKISFFGLGASAsVAHDAQNKFFR--FNVPVLCFDDVLMQRMScinsDEGDVVVLISHTGRTKSLIDIARLAREN 201
Cdd:PRK08674  30 DLEKIDNIVISGMGGSG-IGGDLLRILLFdeLKVPVFVNRDYTLPAFV----DEKTLVIAVSYSGNTEETLSAVEQALKR 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 202 GAAVIGITA--RHSPLSQECTLPVtMEVPEDtdmYLPMASrLAQLVI--IDVLAT-GFTLRRGPRFRESLKRVKEvLKES 276
Cdd:PRK08674 105 GAKIIAITSggKLKEMAKEHGLPV-IIVPGG---YQPRAA-LGYLFTplLKILEKlGLIPDKSAEVLETKIVLSE-LAEG 178


                 ....*...
gi 655376227 277 RIDKSEPL 284
Cdd:PRK08674 179 LKEKVPTL 186
PRK13937 PRK13937
phosphoheptose isomerase; Provisional
 175-211 5.11e-03

phosphoheptose isomerase; Provisional


Pssm-ID: 184408 [Multi-domain]  Cd Length: 188  Bit Score: 37.14  E-value: 5.11e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 655376227 175 EGDVVVLISHTGRTKSLIDIARLARENGAAVIGITAR 211
Cdd:PRK13937 106 PGDVLIGISTSGNSPNVLAALEKARELGMKTIGLTGR 142
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
 130-210 6.97e-03

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 35.70  E-value: 6.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655376227 130 KISFFGLGASASVAHDAQNKFF-RFNVPV-LCFDDVLMQRMscinsDEGDVVVLISHTGRTKSLIDIARLARENGAAVIG 207
Cdd:cd05017    1 NIVILGMGGSGIGGDLLESLLLdEAKIPVyVVKDYTLPAFV-----DRKTLVIAVSYSGNTEETLSAVEQAKERGAKIVA 75


                 ...
gi 655376227 208 ITA 210
Cdd:cd05017   76 ITS 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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