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Conserved domains on  [gi|655507208|ref|WP_028888312|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Tenacibaculum]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 11450212)

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4002925

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 41-178 6.00e-38

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


:

Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 127.30  E-value: 6.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208  41 SPATLQTYLSLGD-LTASGNFSNKFREQLALAIAEENECDYCLSAHTAIGKMNGLTDAETEQNRQGLAA---DEKVQAGL 116
Cdd:COG2128    2 SPELLKAFLALSGaLMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESplfDPRERAAL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 655507208 117 NLAQSITKNRGNISSDEIAAAKvAGYNDSDILEIVLNVVSNTLTNYVNHIAKTEVDFPKVEA 178
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALR-AGFSDAEIVELVLAIALFNMSNRLNNALGTPPDPPFAAL 142
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 41-178 6.00e-38

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 127.30  E-value: 6.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208  41 SPATLQTYLSLGD-LTASGNFSNKFREQLALAIAEENECDYCLSAHTAIGKMNGLTDAETEQNRQGLAA---DEKVQAGL 116
Cdd:COG2128    2 SPELLKAFLALSGaLMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESplfDPRERAAL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 655507208 117 NLAQSITKNRGNISSDEIAAAKvAGYNDSDILEIVLNVVSNTLTNYVNHIAKTEVDFPKVEA 178
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALR-AGFSDAEIVELVLAIALFNMSNRLNNALGTPPDPPFAAL 142
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 14-175 5.54e-16

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 71.67  E-value: 5.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208   14 TGKSKELFDAVQNKLGFIPNLIKVFGNSPATLQ----TYLSLGDltASGNFSNKFREQLALAIAEENECDYCLSAHTAI- 88
Cdd:TIGR01926  12 TEEQKAYLAKIEEKTGFVPNVFRALAHDPEALRartaYFNDLML--GEGGLSRAERELIAVVVSRANGCVYCAAVHGAAl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208   89 ---GKMNGLTDAETEQNRQGLAADEKvQAGLNLAQSITKNRGNISSDEIAAAKVAGYNDSDILEIVlNVVSntLTNYVNH 165
Cdd:TIGR01926  90 rqlSGDPDLADAVAVNFRDADLSPRE-RAMLDFAVKLTATPAKVNEADFAALRAAGFSDLDILDLI-HSVA--FFNWANR 165

                         170
                  ....*....|..
gi 655507208  166 IAKT--EVDFPK 175
Cdd:TIGR01926 166 LMLAlgEPPNPE 177
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 42-120 1.48e-08

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 49.62  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208   42 PATLQTYLSL-GDLTASGNFSNKFREQLALAIAEENECDYCLSAHTAIGKMNGLTD---AETEQNRQGLAADEKVQAGLN 117
Cdd:pfam02627   1 PELLAALTALaFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEeeiAEVLAWAAAYAGGPAARAALA 80


                  ...
gi 655507208  118 LAQ 120
Cdd:pfam02627  81 AAE 83
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 41-178 6.00e-38

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 127.30  E-value: 6.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208  41 SPATLQTYLSLGD-LTASGNFSNKFREQLALAIAEENECDYCLSAHTAIGKMNGLTDAETEQNRQGLAA---DEKVQAGL 116
Cdd:COG2128    2 SPELLKAFLALSGaLMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESplfDPRERAAL 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 655507208 117 NLAQSITKNRGNISSDEIAAAKvAGYNDSDILEIVLNVVSNTLTNYVNHIAKTEVDFPKVEA 178
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALR-AGFSDAEIVELVLAIALFNMSNRLNNALGTPPDPPFAAL 142
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 14-175 5.54e-16

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 71.67  E-value: 5.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208   14 TGKSKELFDAVQNKLGFIPNLIKVFGNSPATLQ----TYLSLGDltASGNFSNKFREQLALAIAEENECDYCLSAHTAI- 88
Cdd:TIGR01926  12 TEEQKAYLAKIEEKTGFVPNVFRALAHDPEALRartaYFNDLML--GEGGLSRAERELIAVVVSRANGCVYCAAVHGAAl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208   89 ---GKMNGLTDAETEQNRQGLAADEKvQAGLNLAQSITKNRGNISSDEIAAAKVAGYNDSDILEIVlNVVSntLTNYVNH 165
Cdd:TIGR01926  90 rqlSGDPDLADAVAVNFRDADLSPRE-RAMLDFAVKLTATPAKVNEADFAALRAAGFSDLDILDLI-HSVA--FFNWANR 165

                         170
                  ....*....|..
gi 655507208  166 IAKT--EVDFPK 175
Cdd:TIGR01926 166 LMLAlgEPPNPE 177
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 42-120 1.48e-08

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 49.62  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208   42 PATLQTYLSL-GDLTASGNFSNKFREQLALAIAEENECDYCLSAHTAIGKMNGLTD---AETEQNRQGLAADEKVQAGLN 117
Cdd:pfam02627   1 PELLAALTALaFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEeeiAEVLAWAAAYAGGPAARAALA 80


                  ...
gi 655507208  118 LAQ 120
Cdd:pfam02627  81 AAE 83
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 58-98 9.58e-06

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 41.20  E-value: 9.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 655507208   58 GNFSNKFREQLALAIAEENECDYCLSAHTAIGKMNGLTDAE 98
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREE 41
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 18-98 9.58e-05

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 39.93  E-value: 9.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 655507208  18 KELFDAVQNklgFIPNLIKVFGN-SPATLQTYLSL-GDLTASGNFSNKFREQLALAIAEENECDYCLSAHTAIGKMNGLT 95
Cdd:COG0599    1 EEVLKEVEE---YVPRALEALAEfAPEFAEAFEALfGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGAT 77


                 ...
gi 655507208  96 DAE 98
Cdd:COG0599   78 REE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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