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Conserved domains on  [gi|656016307|ref|WP_029056213|]
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MULTISPECIES: glycine cleavage system protein H [Staphylococcus]

Protein Classification

glycine cleavage system protein H( domain architecture ID 10160151)

glycine cleavage system protein H plays a role in the degradation of glycine by shuttling the methylamine group of glycine from P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase).

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 7-96 2.17e-23

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


:

Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 86.05  E-value: 2.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307   7 YIKVEKEGNQYVYyMTPELQDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:cd06848    7 WVKVEGDGIATVG-ITDYAQDLLGDIVFVELPEVgTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNPELINS 85

                         90
                 ....*....|.
gi 656016307  86 EKPEDNWLVKL 96
Cdd:cd06848   86 DPYGEGWLVKI 96
 
Name Accession Description Interval E-value
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 7-96 2.17e-23

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 86.05  E-value: 2.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307   7 YIKVEKEGNQYVYyMTPELQDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:cd06848    7 WVKVEGDGIATVG-ITDYAQDLLGDIVFVELPEVgTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNPELINS 85

                         90
                 ....*....|.
gi 656016307  86 EKPEDNWLVKL 96
Cdd:cd06848   86 DPYGEGWLVKI 96
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 26-107 2.08e-17

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 71.69  E-value: 2.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307  26 QDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNSEKPEDNWLVKLEDVDEDAF 104
Cdd:COG0509   33 QDLLGDIVFVELPEVgTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEVNEALEDDPELVNEDPYGEGWLFKIKPSDPAEL 112


                 ...
gi 656016307 105 NAL 107
Cdd:COG0509  113 DDL 115
PRK01202 PRK01202
glycine cleavage system protein GcvH;
26-107 5.71e-14

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 62.87  E-value: 5.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307  26 QDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNSEKPEDNWLVKLEDVDEDAF 104
Cdd:PRK01202  33 QEQLGDIVFVELPEVgDEVKAGETFGVVESVKAASDIYAPVSGEVVEVNEALEDSPELVNEDPYGEGWLFKIKPSDESEL 112


                 ...
gi 656016307 105 NAL 107
Cdd:PRK01202 113 DDL 115
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 7-107 7.03e-13

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 60.04  E-value: 7.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307    7 YIKVEKEGNQYVYyMTPELQDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:pfam01597   9 WVKVEGDGTATVG-ITDFAQAQLGDIVFVELPEVgTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLEDNPGLINK 87

                          90       100
                  ....*....|....*....|..
gi 656016307   86 EKPEDNWLVKLEDVDEDAFNAL 107
Cdd:pfam01597  88 DPYEDGWIAKLKPSNLEELESL 109
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 7-97 6.14e-11

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 55.23  E-value: 6.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307    7 YIKVEKEGNQYVYyMTPELQDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:TIGR00527  14 WVRVEGDKTATVG-ITKFAQDELGDIVFVELPEVgAEVAAGESLGSVESVKAASDIYAPVDGTVVEVNTALEDSPELVNE 92

                          90
                  ....*....|..
gi 656016307   86 EKPEDNWLVKLE 97
Cdd:TIGR00527  93 DPYGDGWLIKVK 104
 
Name Accession Description Interval E-value
GCS_H cd06848
Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage ...
 7-96 2.17e-23

Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-proteins) which catalyzes the oxidative cleavage of glycine. The H-protein shuttles the methylamine group of glycine from the P-protein (glycine dehydrogenase) to the T-protein (aminomethyltransferase) via a lipoyl group, attached to a completely conserved lysine residue.


Pssm-ID: 133457 [Multi-domain]  Cd Length: 96  Bit Score: 86.05  E-value: 2.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307   7 YIKVEKEGNQYVYyMTPELQDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:cd06848    7 WVKVEGDGIATVG-ITDYAQDLLGDIVFVELPEVgTEVKKGDPFGSVESVKAASDLYSPVSGEVVEVNEALLDNPELINS 85

                         90
                 ....*....|.
gi 656016307  86 EKPEDNWLVKL 96
Cdd:cd06848   86 DPYGEGWLVKI 96
GcvH COG0509
Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; ...
 26-107 2.08e-17

Glycine cleavage system protein H (lipoate-binding) [Amino acid transport and metabolism]; Glycine cleavage system protein H (lipoate-binding) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440275  Cd Length: 128  Bit Score: 71.69  E-value: 2.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307  26 QDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNSEKPEDNWLVKLEDVDEDAF 104
Cdd:COG0509   33 QDLLGDIVFVELPEVgTEVEAGEPFGVVESVKAVSDLYAPVSGEVVEVNEALEDDPELVNEDPYGEGWLFKIKPSDPAEL 112


                 ...
gi 656016307 105 NAL 107
Cdd:COG0509  113 DDL 115
PRK01202 PRK01202
glycine cleavage system protein GcvH;
26-107 5.71e-14

glycine cleavage system protein GcvH;


Pssm-ID: 234918  Cd Length: 127  Bit Score: 62.87  E-value: 5.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307  26 QDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNSEKPEDNWLVKLEDVDEDAF 104
Cdd:PRK01202  33 QEQLGDIVFVELPEVgDEVKAGETFGVVESVKAASDIYAPVSGEVVEVNEALEDSPELVNEDPYGEGWLFKIKPSDESEL 112


                 ...
gi 656016307 105 NAL 107
Cdd:PRK01202 113 DDL 115
GCV_H pfam01597
Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the ...
 7-107 7.03e-13

Glycine cleavage H-protein; This is a family of glycine cleavage H-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. A lipoyl group is attached to a completely conserved lysine residue. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


Pssm-ID: 396258  Cd Length: 122  Bit Score: 60.04  E-value: 7.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307    7 YIKVEKEGNQYVYyMTPELQDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:pfam01597   9 WVKVEGDGTATVG-ITDFAQAQLGDIVFVELPEVgTKVKKGESLAAIESVKAASPIYAPVSGEVVEVNEKLEDNPGLINK 87

                          90       100
                  ....*....|....*....|..
gi 656016307   86 EKPEDNWLVKLEDVDEDAFNAL 107
Cdd:pfam01597  88 DPYEDGWIAKLKPSNLEELESL 109
gcvH TIGR00527
glycine cleavage system H protein; This model represents the glycine cleavage system H protein, ...
 7-97 6.14e-11

glycine cleavage system H protein; This model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff. [Energy metabolism, Amino acids and amines]


Pssm-ID: 200024  Cd Length: 128  Bit Score: 55.23  E-value: 6.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307    7 YIKVEKEGNQYVYyMTPELQDDVGTVGYVEFMSP-DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:TIGR00527  14 WVRVEGDKTATVG-ITKFAQDELGDIVFVELPEVgAEVAAGESLGSVESVKAASDIYAPVDGTVVEVNTALEDSPELVNE 92

                          90
                  ....*....|..
gi 656016307   86 EKPEDNWLVKLE 97
Cdd:TIGR00527  93 DPYGDGWLIKVK 104
PRK13380 PRK13380
glycine cleavage system protein H; Provisional
 7-107 1.22e-09

glycine cleavage system protein H; Provisional


Pssm-ID: 237370  Cd Length: 144  Bit Score: 51.93  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307   7 YIKVEKEGNqYVYYMTPELQDDVGTVGYVEFMSPDK-VEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPAILNS 85
Cdd:PRK13380  22 WLRLEGDGT-VTVGITDYAQTMAGDVVFVRLKELGKkVEKGKPVATLESGKWAGPVPAPLTGEVVEVNEALEDSPELVNE 100

                         90       100
                 ....*....|....*....|..
gi 656016307  86 EKPEDNWLVKLEDVDEDAFNAL 107
Cdd:PRK13380 101 DPYGEGWFFRFKPANPEELKQL 122
PRK00624 PRK00624
glycine cleavage system protein H; Provisional
 21-102 8.12e-06

glycine cleavage system protein H; Provisional


Pssm-ID: 167014  Cd Length: 114  Bit Score: 41.35  E-value: 8.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656016307  21 MTPELQDDVGTVGYVEFMSPDKVEKNDEIVSI-EASKTVLDVQSPLAGTIVERNTKAEDEPAILNSEKPEDNWLVKLEdV 99
Cdd:PRK00624  23 LTSKMQENLGNILHIDLPSVGSFCKEGEVLVIlESSKSAIEVLSPVSGEVIEVNTALEDDIQPINNAPESEGWFVVVQ-L 101


                 ...
gi 656016307 100 DED 102
Cdd:PRK00624 102 DED 104
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 41-79 4.80e-05

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 38.54  E-value: 4.80e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 656016307  41 DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDE 79
Cdd:cd06849   26 DSVEEGDVLAEVETDKATVEVEAPAAGVLAKILVEEGDT 64
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 29-96 2.70e-04

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 36.65  E-value: 2.70e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 656016307  29 VGTVGYVEFMSPDKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDEPailnsekPEDNWLVKL 96
Cdd:cd06663   13 DGTVVKWLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKV-------EGDTPLVKI 73
PRK11856 PRK11856
branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed
 41-79 6.58e-04

branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed


Pssm-ID: 237001 [Multi-domain]  Cd Length: 411  Bit Score: 37.46  E-value: 6.58e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 656016307  41 DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDE 79
Cdd:PRK11856  28 DTVKEGQPLAEVETDKATVEIPSPVAGTVAKLLVEEGDV 66
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 41-78 1.34e-03

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 34.31  E-value: 1.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 656016307  41 DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAED 78
Cdd:cd06850   19 DKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGD 56
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 28-78 1.50e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 36.39  E-value: 1.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 656016307   28 DVGTVGYVEFMS-----PDKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAED 78
Cdd:TIGR01348   7 DIGDNEEGEVIEvlvkpGDKVEAGQSLITLESDKASMEVPSSAAGIIKEIKVKVGD 62
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 41-79 4.33e-03

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 33.50  E-value: 4.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 656016307  41 DKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAEDE 79
Cdd:COG0508   28 DTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDT 66
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 22-78 8.76e-03

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 34.32  E-value: 8.76e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 656016307   22 TPELQDDV--GTVGYVEFMSPDKVEKNDEIVSIEASKTVLDVQSPLAGTIVERNTKAED 78
Cdd:TIGR01347   5 VPELAESIteGTVAEWHKKVGDTVKRDENIVEIETDKVVLEVPSPADGVLQEILFKEGD 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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