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Conserved domains on  [gi|656276259|ref|WP_029221912|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Vibrio]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
8-147 2.68e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 137.60  E-value: 2.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259   8 MVDSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLERERVDlm 87
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259  88 hNFKKEMSSNRSVQQCYYVTGSSDFIMIVTAADMEGYDNFTREAFFDNANIKSFQTNVVM 147
Cdd:COG1522   80 -EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
8-147 2.68e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 137.60  E-value: 2.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259   8 MVDSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLERERVDlm 87
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259  88 hNFKKEMSSNRSVQQCYYVTGSSDFIMIVTAADMEGYDNFTREAFFDNANIKSFQTNVVM 147
Cdd:COG1522   80 -EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 10-118 2.95e-33

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 113.38  E-value: 2.95e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259    10 DSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLERErvDLMHN 89
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENP--DKLEE 79

                           90       100
                   ....*....|....*....|....*....
gi 656276259    90 FKKEMSSNRSVQQCYYVTGSSDFIMIVTA 118
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-151 1.12e-22

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 88.28  E-value: 1.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259   1 MTQQPALMVDSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLE 80
Cdd:PRK11169   4 SKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 656276259  81 RERVDLMHNFKKEMSSNRSVQQCYYVTGSSDFIMIVTAADMEGYDNFTREAFFDNANIKSFQTNVVMDNVK 151
Cdd:PRK11169  84 RGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVK 154
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 75-147 2.10e-14

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 64.08  E-value: 2.10e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 656276259   75 VQVTLERERVdlMHNFKKEMSSNRSVQQCYYVTGSSDFIMIVTAADMEGYDNFTREAFFDNANIKSFQTNVVM 147
Cdd:pfam01037   1 VEVKLEPGHA--LEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVL 71
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-57 2.47e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.06  E-value: 2.47e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 656276259  10 DSFDKKILNIVQDSNRATSDkIAEKVGLSPAAVQRRLKRMRAQGVIQA 57
Cdd:cd00090    6 DPTRLRILRLLLEGPLTVSE-LAERLGLSQSTVSRHLKKLEEAGLVES 52
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
8-147 2.68e-42

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 137.60  E-value: 2.68e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259   8 MVDSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLERERVDlm 87
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259  88 hNFKKEMSSNRSVQQCYYVTGSSDFIMIVTAADMEGYDNFTREAFFDNANIKSFQTNVVM 147
Cdd:COG1522   80 -EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 10-118 2.95e-33

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 113.38  E-value: 2.95e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259    10 DSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLERErvDLMHN 89
Cdd:smart00344   2 DEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENP--DKLEE 79

                           90       100
                   ....*....|....*....|....*....
gi 656276259    90 FKKEMSSNRSVQQCYYVTGSSDFIMIVTA 118
Cdd:smart00344  80 FLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-151 1.12e-22

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 88.28  E-value: 1.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259   1 MTQQPALMVDSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLE 80
Cdd:PRK11169   4 SKKRPGKDLDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 656276259  81 RERVDLMHNFKKEMSSNRSVQQCYYVTGSSDFIMIVTAADMEGYDNFTREAFFDNANIKSFQTNVVMDNVK 151
Cdd:PRK11169  84 RGAPDVFEQFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVK 154
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 75-147 2.10e-14

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 64.08  E-value: 2.10e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 656276259   75 VQVTLERERVdlMHNFKKEMSSNRSVQQCYYVTGSSDFIMIVTAADMEGYDNFTREAFFDNANIKSFQTNVVM 147
Cdd:pfam01037   1 VEVKLEPGHA--LEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVL 71
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
10-50 5.48e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 59.69  E-value: 5.48e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 656276259   10 DSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMR 50
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
13-55 3.14e-12

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 57.83  E-value: 3.14e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 656276259   13 DKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVI 55
Cdd:pfam13412   3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 9-117 1.59e-08

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 50.86  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656276259   9 VDSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQADVSVINPKAVGHGMTFIVQVTLERERvDlMH 88
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSAK-D-YP 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 656276259  89 NFKKEMSSNRSVQQCYYVTGS-SDFIMIVT 117
Cdd:PRK11179  85 SALAKLESLDEVVEAYYTTGHySIFIKVMC 114
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-57 2.47e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 43.06  E-value: 2.47e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 656276259  10 DSFDKKILNIVQDSNRATSDkIAEKVGLSPAAVQRRLKRMRAQGVIQA 57
Cdd:cd00090    6 DPTRLRILRLLLEGPLTVSE-LAERLGLSQSTVSRHLKKLEEAGLVES 52
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 13-56 2.46e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.97  E-value: 2.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 656276259  13 DKKILNIVQDSN-RATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQ 56
Cdd:COG2512   17 ERRVLELLRENGgRMTQSEIVKETGWSKSKVSRLLSRLEERGLIE 61
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
1-57 3.96e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 3.96e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 656276259   1 MTQQPALMV--DSFDKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQA 57
Cdd:COG2345    1 MTDTPALAAlaDPTRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVER 59
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
15-55 8.56e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 36.03  E-value: 8.56e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 656276259    15 KILNIVQDSNRATSDkIAEKVGLSPAAVQRRLKRMRAQGVI 55
Cdd:smart00418   1 KILKLLAEGELCVCE-LAEILGLSQSTVSHHLKKLREAGLV 40
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
13-56 9.54e-04

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 37.25  E-value: 9.54e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 656276259  13 DKKILNIVQDSNR-ATSDKIAEKVGLSPAAVQRRLKRMRAQGVIQ 56
Cdd:COG3355   29 DAEVYLILLENGEpLTVEELAEALDRSRSTVYRSLQKLLEAGLVE 73
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 16-55 1.17e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.64  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 656276259   16 ILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVI 55
Cdd:pfam12802  10 VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
13-55 1.26e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.17  E-value: 1.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 656276259  13 DKKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVI 55
Cdd:COG3398   99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV 141
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
14-55 3.53e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.56  E-value: 3.53e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 656276259  14 KKILNIVQDSNRATSDKIAEKVGLSPAAVQRRLKRMRAQGVI 55
Cdd:COG1321   13 KAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLV 54
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
31-58 7.73e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 32.80  E-value: 7.73e-03
                           10        20
                   ....*....|....*....|....*...
gi 656276259    31 IAEKVGLSPAAVQRRLKRMRAQGVIQAD 58
Cdd:smart00419  14 IAELLGLTRETVSRTLKRLEKEGLISRE 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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