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Conserved domains on  [gi|656290532|ref|WP_029235856|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Vibrio]

Protein Classification

class I SAM-dependent DNA methyltransferase( domain architecture ID 11471966)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047
PubMed:  23180741|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
5-145 1.02e-27

Predicted methyltransferase, contains TPR repeat [General function prediction only];


:

Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 104.31  E-value: 1.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   5 ALYTDLSGYYD-LMCVDIDYQAQSNCVRR-LHQIFGNEGKTHLDLACGTGPHVRHFIDFGYQSGGLDLNKPMLDIAEVRC 82
Cdd:COG4976    9 ALFDQYADSYDaALVEDLGYEAPALLAEElLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 656290532  83 PEAKFSVQNMSNFEVT-EPLDLITCFLySIHYndgLEKLKECIESVHRALKPEGIFCFNVVDKD 145
Cdd:COG4976   89 VYDRLLVADLADLAEPdGRFDLIVAAD-VLTY---LGDLAAVFAGVARALKPGGLFIFSVEDAD 148
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
5-145 1.02e-27

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 104.31  E-value: 1.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   5 ALYTDLSGYYD-LMCVDIDYQAQSNCVRR-LHQIFGNEGKTHLDLACGTGPHVRHFIDFGYQSGGLDLNKPMLDIAEVRC 82
Cdd:COG4976    9 ALFDQYADSYDaALVEDLGYEAPALLAEElLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 656290532  83 PEAKFSVQNMSNFEVT-EPLDLITCFLySIHYndgLEKLKECIESVHRALKPEGIFCFNVVDKD 145
Cdd:COG4976   89 VYDRLLVADLADLAEPdGRFDLIVAAD-VLTY---LGDLAAVFAGVARALKPGGLFIFSVEDAD 148
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 45-135 5.08e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.27  E-value: 5.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   45 LDLACGTGPHVRHFIDFGYQSG-GLDLNKPMLDIAEVRC----PEAKFSVQNMSNFEV-TEPLDLITCFlYSIHYNDgLE 118
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVtGVDLSPEMLERARERAaeagLNVEFVQGDAEDLPFpDGSFDLVVSS-GVLHHLP-DP 79

                          90
                  ....*....|....*..
gi 656290532  119 KLKECIESVHRALKPEG 135
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 45-137 2.04e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.29  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  45 LDLACGTGPHVRHFIDFGYQSG---GLDLNKPMLDIAEVRCPEAKFSvqnmSNFEVTE------PL-----DLITcflys 110
Cdd:PRK00216  56 LDLACGTGDLAIALAKAVGKTGevvGLDFSEGMLAVGREKLRDLGLS----GNVEFVQgdaealPFpdnsfDAVT----- 126

                         90       100       110
                 ....*....|....*....|....*....|
gi 656290532 111 IHYndGL---EKLKECIESVHRALKPEGIF 137
Cdd:PRK00216 127 IAF--GLrnvPDIDKALREMYRVLKPGGRL 154
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 45-142 5.44e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.57  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  45 LDLACGTGPHVRHFIDF-GYQSGGLDLNKPMLDIAEV-----RCPEAKFSVQNMSNFEVT--EPLDLITCFLYSIHYNDG 116
Cdd:cd02440    3 LDLGCGTGALALALASGpGARVTGVDISPVALELARKaaaalLADNVEVLKGDAEELPPEadESFDVIISDPPLHHLVED 82

                         90       100
                 ....*....|....*....|....*.
gi 656290532 117 LEKLkecIESVHRALKPEGIFCFNVV 142
Cdd:cd02440   83 LARF---LEEARRLLKPGGVLVLTLV 105
 
Name Accession Description Interval E-value
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
5-145 1.02e-27

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 104.31  E-value: 1.02e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   5 ALYTDLSGYYD-LMCVDIDYQAQSNCVRR-LHQIFGNEGKTHLDLACGTGPHVRHFIDFGYQSGGLDLNKPMLDIAEVRC 82
Cdd:COG4976    9 ALFDQYADSYDaALVEDLGYEAPALLAEElLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKG 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 656290532  83 PEAKFSVQNMSNFEVT-EPLDLITCFLySIHYndgLEKLKECIESVHRALKPEGIFCFNVVDKD 145
Cdd:COG4976   89 VYDRLLVADLADLAEPdGRFDLIVAAD-VLTY---LGDLAAVFAGVARALKPGGLFIFSVEDAD 148
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
45-141 7.88e-15

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 67.93  E-value: 7.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  45 LDLACGTGPHVRHFID--FGYQSGGLDLNKPMLDIAEVRCPEAKFSVQNMSNFEVTEPLDLITCFlYSIHYNDGLEKLke 122
Cdd:COG4106    6 LDLGCGTGRLTALLAErfPGARVTGVDLSPEMLARARARLPNVRFVVADLRDLDPPEPFDLVVSN-AALHWLPDHAAL-- 82

                         90
                 ....*....|....*....
gi 656290532 123 cIESVHRALKPEGIFCFNV 141
Cdd:COG4106   83 -LARLAAALAPGGVLAVQV 100
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 31-141 1.61e-14

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 68.12  E-value: 1.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  31 RRLHQI---FGNEGKTHLDLACGTGPHVRHFIDFGYQSGGLDLNKPMLDIAEVRCPE--AKFSVQNMSNFEVT-EPLDLI 104
Cdd:COG2227   12 RRLAALlarLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAElnVDFVQGDLEDLPLEdGSFDLV 91

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 656290532 105 TCFlYSIHYndgLEKLKECIESVHRALKPEGIFCFNV 141
Cdd:COG2227   92 ICS-EVLEH---LPDPAALLRELARLLKPGGLLLLST 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 33-139 1.86e-14

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 68.10  E-value: 1.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  33 LHQIFGNEGKTHLDLACGTGPHVRHFIDFGYQSGGLDLNKPMLDIAEVRCPEAKFSVQ----NMSNFEV-TEPLDLITCF 107
Cdd:COG2226   15 LAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERAAEAGLNVEfvvgDAEDLPFpDGSFDLVISS 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 656290532 108 lYSIHYndgLEKLKECIESVHRALKPEGIFCF 139
Cdd:COG2226   95 -FVLHH---LPDPERALAEIARVLKPGGRLVV 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 39-145 7.58e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 68.02  E-value: 7.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  39 NEGKTHLDLACGTGPHVRHFID-FGYQSGGLDLNKPMLDIAEVRCPEAK-----FSVQNMSNFE--VTEPLDLITCFlYS 110
Cdd:COG0500   25 PKGGRVLDLGCGTGRNLLALAArFGGRVIGIDLSPEAIALARARAAKAGlgnveFLVADLAELDplPAESFDLVVAF-GV 103

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 656290532 111 IHYNDgLEKLKECIESVHRALKPEGIFCFNVVDKD 145
Cdd:COG0500  104 LHHLP-PEEREALLRELARALKPGGVLLLSASDAA 137
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 45-135 5.08e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.27  E-value: 5.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   45 LDLACGTGPHVRHFIDFGYQSG-GLDLNKPMLDIAEVRC----PEAKFSVQNMSNFEV-TEPLDLITCFlYSIHYNDgLE 118
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGARVtGVDLSPEMLERARERAaeagLNVEFVQGDAEDLPFpDGSFDLVVSS-GVLHHLP-DP 79

                          90
                  ....*....|....*..
gi 656290532  119 KLKECIESVHRALKPEG 135
Cdd:pfam13649  80 DLEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 45-139 5.32e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 60.37  E-value: 5.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   45 LDLACGTGPHVRHFIDFGYQSGGLDLNKPMLDIAEVRCPEAKFSVQNMSNFEVtePL-----DLITCFLYSIHYNDGLEK 119
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKAPREGLTFVVGDAEDL--PFpdnsfDLVLSSEVLHHVEDPERA 78

                          90       100
                  ....*....|....*....|
gi 656290532  120 LKECiesvHRALKPEGIFCF 139
Cdd:pfam08241  79 LREI----ARVLKPGGILII 94
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 24-139 6.10e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 50.70  E-value: 6.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  24 QAQSNCVRRLHQIFG-NEGKTHLDLACGTGPHVRHFID-FGYQSGGLDLNKPMLDIAEVRCPEA------KFSVQNMSNF 95
Cdd:COG2230   34 EAQEAKLDLILRKLGlKPGMRVLDIGCGWGGLALYLARrYGVRVTGVTLSPEQLEYARERAAEAgladrvEVRLADYRDL 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 656290532  96 EVTEPLDLITCFLYSIHYndGLEKLKECIESVHRALKPEGIFCF 139
Cdd:COG2230  114 PADGQFDAIVSIGMFEHV--GPENYPAYFAKVARLLKPGGRLLL 155
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 45-137 1.91e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 47.75  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   45 LDLACGTGPHVRHFIDF--GYQSGGLDLNKPMLDIAEVRCPEAKFSVQNMSNFEVTEPL-------DLITCFlYSIHYnd 115
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGeldpgsfDVVVAS-NVLHH-- 77

                          90       100
                  ....*....|....*....|..
gi 656290532  116 gLEKLKECIESVHRALKPEGIF 137
Cdd:pfam08242  78 -LADPRAVLRNIRRLLKPGGVL 98
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 22-152 1.83e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 43.57  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   22 DYQAQSNCVRRLHQIFGN--EGKTHLDLACGTGPHVRHFIDFGYQSGGLDLNKPMLDIAEVRCPEAKFSVQNMSNFEvtE 99
Cdd:pfam13489   2 AHQRERLLADLLLRLLPKlpSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPA--G 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 656290532  100 PLDLITCF--LYSIHYNDGLeklkecIESVHRALKPEGIFCFNVVDKDKISNDLF 152
Cdd:pfam13489  80 KFDVIVARevLEHVPDPPAL------LRQIAALLKPGGLLLLSTPLASDEADRLL 128
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 45-137 2.04e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.29  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  45 LDLACGTGPHVRHFIDFGYQSG---GLDLNKPMLDIAEVRCPEAKFSvqnmSNFEVTE------PL-----DLITcflys 110
Cdd:PRK00216  56 LDLACGTGDLAIALAKAVGKTGevvGLDFSEGMLAVGREKLRDLGLS----GNVEFVQgdaealPFpdnsfDAVT----- 126

                         90       100       110
                 ....*....|....*....|....*....|
gi 656290532 111 IHYndGL---EKLKECIESVHRALKPEGIF 137
Cdd:PRK00216 127 IAF--GLrnvPDIDKALREMYRVLKPGGRL 154
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 39-138 2.76e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 40.09  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532   39 NEGKTHLDLACGTGPHVRHFIDFGYQSG---GLDLNKPMLDIAEVRCPE-----AKFSVQNMSNFEVT---EPLDLITCF 107
Cdd:pfam13847   2 DKGMRVLDLGCGTGHLSFELAEELGPNAevvGIDISEEAIEKARENAQKlgfdnVEFEQGDIEELPELledDKFDVVISN 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 656290532  108 LYSIHYNDglekLKECIESVHRALKPEGIFC 138
Cdd:pfam13847  82 CVLNHIPD----PDKVLQEILRVLKPGGRLI 108
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 45-142 5.44e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.57  E-value: 5.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 656290532  45 LDLACGTGPHVRHFIDF-GYQSGGLDLNKPMLDIAEV-----RCPEAKFSVQNMSNFEVT--EPLDLITCFLYSIHYNDG 116
Cdd:cd02440    3 LDLGCGTGALALALASGpGARVTGVDISPVALELARKaaaalLADNVEVLKGDAEELPPEadESFDVIISDPPLHHLVED 82

                         90       100
                 ....*....|....*....|....*.
gi 656290532 117 LEKLkecIESVHRALKPEGIFCFNVV 142
Cdd:cd02440   83 LARF---LEEARRLLKPGGVLVLTLV 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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