|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
1-447 |
0e+00 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 594.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 1 MQRYWSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARK 80
Cdd:PRK01766 4 TQKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 81 QDEVRPAVHQGFWLALIVTPIAMVALYFS-PLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPT 159
Cdd:PRK01766 84 RERIAHQVRQGLWLALFLSVLIMLVLYNAvPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 160 MVIGFVGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLFAQLARPNGSRIWRLFR 239
Cdd:PRK01766 164 MVIGFLGLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWAVIKRLLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 240 LGFPIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLM 319
Cdd:PRK01766 244 LGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 320 LGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGL 399
Cdd:PRK01766 324 VGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFFITFIAYWVLGL 403
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 657198907 400 PTGMILGLTDwvvpRMGPQGFWIGFIVGLTSAALMLGARLRVIYGRFA 447
Cdd:PRK01766 404 PLGYILALTD----PMGPFGFWIGLIIGLTAAAILLLLRLRKLQRQPS 447
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
7-445 |
6.65e-180 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 509.73 E-value: 6.65e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 7 EAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRP 86
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 87 AVHQGFWLALIVTPIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVG 166
Cdd:cd13131 81 AVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 167 LAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLFAQLARPNGSRIWRLFRLGFPIAM 246
Cdd:cd13131 161 LVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYRLFARFWRPDWARLKELLRLGLPIGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 247 AIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAA 326
Cdd:cd13131 241 TIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 327 ATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTGMILG 406
Cdd:cd13131 321 LTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLPLGYLLA 400
|
410 420 430
....*....|....*....|....*....|....*....
gi 657198907 407 LTDwvvpRMGPQGFWIGFIVGLTSAALMLGARLRVIYGR 445
Cdd:cd13131 401 FTT----GLGAFGVWIGLIIGLALAAILLLWRFRRLQRR 435
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
9-438 |
6.03e-99 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 303.22 E-value: 6.03e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAV 88
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 89 HQGFWLALIVT-PIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGL 167
Cdd:COG0534 88 GQALLLALLLGlLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 168 AVNIPANYIFIHGhfgmPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLFAqlARPNGSRIWRLFRLGFPIAMA 247
Cdd:COG0534 168 VLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRD--LRPDRKILKRILRIGLPAGLQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 248 IFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAAA 327
Cdd:COG0534 242 QLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 328 TAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTGMILGL 407
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF 401
|
410 420 430
....*....|....*....|....*....|.
gi 657198907 408 TDWvvprmGPQGFWIGFIVGLTSAALMLGAR 438
Cdd:COG0534 402 LGL-----GLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
17-361 |
1.06e-85 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 266.03 E-value: 1.06e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 17 PILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAVHQGFWLAL 96
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 97 IVT-PIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGLAVNIPANY 175
Cdd:TIGR00797 81 LLGlPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 176 IFIHGHFGMpkLGGVGCGVATAIVLWAMLLAMIVYVKcsaHFKRINLFAQLA-RPNGSRIWRLFRLGFPIAMAIFCEVTL 254
Cdd:TIGR00797 161 ILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIK---KAKKIGLKWEGLlKPDWEVLKRLLKLGLPIAFRVILESLS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 255 FTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAAATAALTVL 334
Cdd:TIGR00797 236 FALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILIL 315
|
330 340
....*....|....*....|....*..
gi 657198907 335 LRDPIAGIYTDDLQVIGLAATLLFFAA 361
Cdd:TIGR00797 316 FREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-440 |
2.27e-71 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 232.03 E-value: 2.27e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAV 88
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 89 HQGFWLALIVTPIAMVALYF-SPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGL 167
Cdd:cd13133 85 WQGLYFSLLLAPLLALLSALaAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 168 AVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLFAQLaRPNGSRIWRLFRLGFPIAMA 247
Cdd:cd13133 165 VVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGLRRAW-RFDRELLRRILRLGLPSGLQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 248 IFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAAA 327
Cdd:cd13133 244 FFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 328 TAALTVLLRDPIAGIYTDDL---QVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTGMI 404
Cdd:cd13133 324 LGILFLLFPELLLSIFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYL 403
|
410 420 430
....*....|....*....|....*....|....*.
gi 657198907 405 LgltdwVVPRMGPQGFWIGFIVGLTSAALMLGARLR 440
Cdd:cd13133 404 L-----VVLGAGLAGAWTVETVYVIVLALIFLLRFR 434
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
7-435 |
1.22e-67 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 223.47 E-value: 1.22e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 7 EAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRP 86
Cdd:PRK00187 8 ELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGATR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 87 AVHQGFWLALIVTPIAMVALY-FSPLALQFMDVdPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFV 165
Cdd:PRK00187 88 LAQAGLWLAWLLALVAALLLWnLKPLLLLFGQA-PQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 166 GLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLFAQLARPNGSRIWRLFRLGFPIA 245
Cdd:PRK00187 167 GAVANLLLNYALIEGWFGLPKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRKGLSRPSRAALRELWRLGLPIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 246 MAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVA 325
Cdd:PRK00187 247 GTYAVEVGLFTFAALCMGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVM 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 326 AATAALTVLLRDPIAGIYTD-----DLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLP 400
Cdd:PRK00187 327 LLFAGLFWLLPEAIIGLFLDrndpaFAEIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAP 406
|
410 420 430
....*....|....*....|....*....|....*.
gi 657198907 401 TGMILGLT-DWvvprmGPQGFWIGFIVGLTSAALML 435
Cdd:PRK00187 407 LAWLLAFTlGW-----GAVGVWWGLALGLACAAVAL 437
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-440 |
4.95e-62 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 207.75 E-value: 4.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAV 88
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 89 HQGFWLALIVT-PIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGL 167
Cdd:cd13137 81 GQSLLLALLLSlPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 168 AVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLfaQLARPNGSRIWRLFRLGFPIAMA 247
Cdd:cd13137 161 VLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISF--KGFRLDRKIIKKLLRIGLPAGLE 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 248 IFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAAA 327
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 328 TAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTGMILGL 407
Cdd:cd13137 319 LGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGF 398
|
410 420 430
....*....|....*....|....*....|...
gi 657198907 408 TDWvvprMGPQGFWIGFIVGLTSAALMLGARLR 440
Cdd:cd13137 399 VLG----LGLTGIWLAMFVDTIVRAILLLYRFR 427
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
7-436 |
3.49e-61 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 205.50 E-value: 3.49e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 7 EAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFW-LPIILLVQGIIMALTPIVSQLNGARKQDEVR 85
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFAnVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 86 PAVHQGFW-LALIVTPIAMVALYFSPLaLQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGF 164
Cdd:cd13132 81 VYLQRALViLLLCCVPISLLWLNTEPI-LLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 165 VGLAVNIPANYIFIHGHfgmpKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRinLFAQLARPNGSRIWRLFRLGFPI 244
Cdd:cd13132 160 VALLLNILLNYLLVFVL----GLGFIGAALATSISYWLIVVLLLLYIFFSKGHKA--TWGGFSREAFRGWGPFLKLAIPS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 245 AMAIFCEVTLFTVVALMLAPFGAET-VASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMG 323
Cdd:cd13132 234 ALMLCLEWWAFEILVLLAGLLPGTVaLAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 324 VAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGyKDTQAIF-YVTIVAYWGLGLPTG 402
Cdd:cd13132 314 IGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRG-CGRQKLGaYVNLVAYYLIGLPVG 392
|
410 420 430
....*....|....*....|....*....|....
gi 657198907 403 MILGltdwVVPRMGPQGFWIGFIVGLTSAALMLG 436
Cdd:cd13132 393 LLLA----FVLGLGLKGLWIGLIAGLILQAVILL 422
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-426 |
1.56e-58 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 198.49 E-value: 1.56e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAV 88
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 89 HQGFWLALIV-TPIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLP----AFVMFQVLRNFSeglsHTMPTMVIG 163
Cdd:cd13134 83 GVALLFNLLLgLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFlqalSLTLSAILRSHG----RTKIPMYVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 164 FVGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIvlwAMLLAMIVYVKCSAHFKRINLFAQLARPNGSRIWR-LFRLGF 242
Cdd:cd13134 159 LIMNILNIVGNYLLIFGWFGLPKLGVAGVAISTVI---SRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKkILKIGL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 243 PIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGM 322
Cdd:cd13134 236 PSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 323 GVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTG 402
Cdd:cd13134 316 LVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLA 395
|
410 420
....*....|....*....|....
gi 657198907 403 MILGltdwVVPRMGPQGFWIGFIV 426
Cdd:cd13134 396 YLLG----IVLGLGLLGVWIAFAA 415
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
15-440 |
9.01e-54 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 185.61 E-value: 9.01e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 15 ASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAVHQGFWL 94
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 95 ALIV-TPIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGLAVNIPA 173
Cdd:cd12082 81 AILLgLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 174 NYIFIHGhFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLFaqLARPNGSRIWRLFRLGFPIAMAIFCEVT 253
Cdd:cd12082 161 DPLLIFG-LGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLS--LLKPDLELLRRLLRIGLPSAIQNSLLSL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 254 LFTVVALMLAPF-GAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAAATAALT 332
Cdd:cd12082 238 GLLIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLI 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 333 VLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTGMILGLTDwvv 412
Cdd:cd12082 318 LLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG--- 394
|
410 420
....*....|....*....|....*...
gi 657198907 413 prMGPQGFWIGFIVGLTSAALMLGARLR 440
Cdd:cd12082 395 --LGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-435 |
7.51e-47 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 167.25 E-value: 7.51e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVD-LAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPA 87
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAaLAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 88 VHQGFWLALIVTPIAMVALY-FSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVG 166
Cdd:cd13138 83 VGTLLVLFLILGIVLTILGLlFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 167 LAVNIPANYIFIhghfGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLfaQLARPNGSRIWRLFRLGFPIAM 246
Cdd:cd13138 163 CVLNIILDLLFI----AVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSL--KDFRFDKEILKEILKIGLPSAL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 247 AIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAA 326
Cdd:cd13138 237 QQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 327 ATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTGMILG 406
Cdd:cd13138 317 IIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLS 396
|
410 420
....*....|....*....|....*....
gi 657198907 407 LTdwvvPRMGPQGFWIGFIVGLTSAALML 435
Cdd:cd13138 397 RL----TGLGLFGIWLAMPISNILSAIIC 421
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-427 |
1.05e-45 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 164.67 E-value: 1.05e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 8 AKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVAssfWlPIILLV----QGIIMALTPIVSQLNGARKQDE 83
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSIS---W-PLIFLFislgGGLTVAGTALVAQYTGAGDYDK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 84 VRPAVHQGFWLALIVTPIAMVALYF--SPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMV 161
Cdd:cd13142 86 ANKVAGQTFSFVIILSLILAVLGYIlsRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 162 IGFVGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAI---VLWAMLLAMIVYVKCSAHFKRINLfaqlaRPNGSRIWRLF 238
Cdd:cd13142 166 IMFGSVLLNVILDPLLIFGIGPFPGLGVAGAALATVIsrgIAAVIGLYLLFKGRVGLKISLRDL-----KPDWEWLKKIF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 239 RLGFPIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGL 318
Cdd:cd13142 241 RIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 319 MLGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLG 398
Cdd:cd13142 321 LLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIR 400
|
410 420
....*....|....*....|....*....
gi 657198907 399 LPTGMILGLtdwvVPRMGPQGFWIGFIVG 427
Cdd:cd13142 401 IPLAYLLAY----VLGLGVTGIWIAMAIS 425
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-392 |
1.06e-37 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 142.66 E-value: 1.06e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 8 AKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSF-WL--PIILLVqgiIMALTPIVSQLNGARKQDEV 84
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFvWLayALALLS---KIGAQVKVSQSIGAKDEKEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 85 RPAVHQGFWLALIVTPIAMVALY-FSPLALQFMDV-DPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVI 162
Cdd:cd13140 81 RKYARNALQLNLLLGILYGLLLLlFAKPLIGFFNLgDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 163 GFVGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSahFKRINLFAQLARPNGSRIWRLFRLGF 242
Cdd:cd13140 161 NAIGLVLNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKK--KGLFLKIRILKRPDRKYIKEILKLGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 243 PIAM--AIFCEVTLftVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLML 320
Cdd:cd13140 239 PVALqsILFALISM--ILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKI 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657198907 321 GMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIV 392
Cdd:cd13140 317 ASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIV 388
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
9-440 |
1.19e-31 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 125.37 E-value: 1.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQ-VSAVDLAAVSVASS-----FWLPIILLvqgiiMALTPIVSQLNGARKQD 82
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHlGSAAYLGAVALGTTifntlFWLFGFLR-----MGTTGLVAQALGAGDRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 83 EVRPAVHQGFWLALIVTPIAMVALY-FSPLALQFMDVDPVMAAKTAGYLHAILWGLPA----FVMFQVLRnfseGLSHTM 157
Cdd:cd13136 78 EAIALLVRALLLALAIGLLLILLQSpLLALALLLLGASAAVAALARQYLRIRILGAPAvllnYVATGWFR----GLQDTR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 158 PTMVIGFVGLAVNIPANYIFIHGhFGMpklGGVGCGVATAIVLWAMLLAMIVYVKcsAHFKRINLFAQLARPNGSRIWRL 237
Cdd:cd13136 154 TPLILQIVGNVVNIVLDPLFVFG-LGW---GVAGAALATVIAQYLGALLGLWLLR--RRVRLLGKSLSRRLPSKAALKRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 238 FRLGFPIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTG 317
Cdd:cd13136 228 FKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 318 LMLGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAywgl 397
Cdd:cd13136 308 LQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS---- 383
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 657198907 398 glpTGMILGLTDWVVPRMGPQGFWIGFIVGLTSAALMLGARLR 440
Cdd:cd13136 384 ---LAVFLPLLFLLVPLWGNHGLWLALILFMLLRGLTLALRLP 423
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
17-176 |
1.38e-28 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 110.35 E-value: 1.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 17 PILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAVHQGFWLAL 96
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 97 IV-TPIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGLAVNIPANY 175
Cdd:pfam01554 81 LLsLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 657198907 176 I 176
Cdd:pfam01554 161 L 161
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
243-404 |
2.99e-25 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 101.10 E-value: 2.99e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 243 PIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGM 322
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 323 GVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYwGLGLPTG 402
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL-LLNIPLN 159
|
..
gi 657198907 403 MI 404
Cdd:pfam01554 160 YL 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-391 |
1.05e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 102.76 E-value: 1.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAV 88
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 89 HQGFWLALIVTPIAMVALYFSPLAL-QFMDVDPVMAAKTAGYLHA-------ILWGLPAFVMFQvlrnfseGLSHTMPTM 160
Cdd:cd13135 81 ISSIVYNSIIGVILFLLWLFGARIIfVLFGVDGQILGYSINYVRIfsiylllLGILFTFSSILQ-------GIGETKPIM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 161 VIGFVGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLFAQLARPNGSRIWRLFRL 240
Cdd:cd13135 154 YGGIIKNLLNVILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCRKIKKLTFKLSNTKVLKANIRPYKFTIKL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 241 GFPIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLML 320
Cdd:cd13135 234 GLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 657198907 321 GMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTI 391
Cdd:cd13135 314 GLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQI 384
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
9-375 |
3.40e-23 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 101.43 E-value: 3.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQ-VSAVDLAAVSVAssfwLPIILLVQGIIMAL----TPIVSQLNGARKQDE 83
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLV----FPIIMLLMALGLMIgvggASLISRRLGAGDREK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 84 VRPAVHQGFWLALIVTPIAMVALY-FSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNF--SEGLSHTMptM 160
Cdd:cd13143 80 ANRIFSTALLLSLILGLLLTILGLlFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLlrAEGKPKLA--M 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 161 VIGFVGLAVNIPANYIFIHGhFGMpklGGVGCGVATAIvlwAMLLAMIVYVKCSAHFKR-INLFAQLARPNGSRIWRLFR 239
Cdd:cd13143 158 LGMLIGAVLNIILDPLFIFV-LGL---GIAGAALATVI---AQLISLLLLLLYFFRGKSlLKLSLLRFKLSLKIIKEILA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 240 LGFP-IAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGL 318
Cdd:cd13143 231 LGFPsFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLAL 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 657198907 319 MLGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAA 375
Cdd:cd13143 311 IVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSG 367
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-407 |
3.72e-23 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 101.14 E-value: 3.72e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 11 LVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAVHQ 90
Cdd:cd13145 11 IRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 91 GFWLALIVTP-IAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGLAV 169
Cdd:cd13145 91 GLSFGIILAIlLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 170 NIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLfaQLARPNGSRIWRLFRLGFPIAMAIF 249
Cdd:cd13145 171 NIILDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRL--RDFIPRLDVYKEILKQGFPASLNMM 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 250 CEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAAATA 329
Cdd:cd13145 249 TIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVAT 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 330 ALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTI--------------VAYW 395
Cdd:cd13145 329 VFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLyrqlvgpalvfwllVNVL 408
|
410
....*....|..
gi 657198907 396 GLGLpTGMILGL 407
Cdd:cd13145 409 GLGV-TGIWWGI 419
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-361 |
3.66e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 89.30 E-value: 3.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 6 SEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVR 85
Cdd:cd13141 8 SIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEAN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 86 PAVHQGFWLALIVTPIAMVALY-FSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGF 164
Cdd:cd13141 88 AVFNQSLLLAAVLGLVVLVLGYlFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 165 VGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLfaQLARPNGSRIWRLFRLGFPI 244
Cdd:cd13141 168 LAVLLNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDL--ALWRPDLPTWKRLLKIGLPS 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 245 AMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGV 324
Cdd:cd13141 246 GGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTAL 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 657198907 325 AAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAA 361
Cdd:cd13141 326 MLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVS 362
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-433 |
4.39e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 86.13 E-value: 4.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 14 LASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAVHQGFW 93
Cdd:cd13139 19 LAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAIL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 94 LALIVT-PIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGLAVNIP 172
Cdd:cd13139 99 LGVALSlILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWLANGLNII 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 173 ANYIFIHGHFGMPKLGGVGCGVATAIVLwAMLLAMIVYVKCSAHFkRINLFAQLARPNGSRIWRLFRLGFPIAMAIFCEV 252
Cdd:cd13139 179 LDPLFIFGLGPIPAMGVTGAAIATTIGR-SIGVLYQLYHLFKGKG-RIQIRRRHLKLDWAIIKKIIKIAVGGILQFLIAS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 253 TLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAAATAALT 332
Cdd:cd13139 257 SSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIVSLVF 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 333 VLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYWGLGLPTGMILGltdwVV 412
Cdd:cd13139 337 FLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLA----RH 412
|
410 420
....*....|....*....|.
gi 657198907 413 PRMGPQGFWIGFIVGLTSAAL 433
Cdd:cd13139 413 LNLGPKGVFIAIPIAETVLAI 433
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-362 |
2.97e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 83.51 E-value: 2.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 8 AKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPA 87
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 88 VHQGFWLALIVTP-IAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVG 166
Cdd:cd13149 88 ATDSLILSLLLSViVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 167 LAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVlWAMLLAMIVYVkcsAHFK-RINLFAQLARPNGSRIWR-LFRLGFPI 244
Cdd:cd13149 168 ALVNVILDPILIFGFGPIPGMGIAGAAIATVIS-RALGLGAALYF---LHYHhRLIDFSEPSLKALFRSWKdILSIGIPA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 245 AMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGV 324
Cdd:cd13149 244 ALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIY 323
|
330 340 350
....*....|....*....|....*....|....*...
gi 657198907 325 AAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAI 362
Cdd:cd13149 324 GAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPI 361
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
4-423 |
7.28e-17 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 82.48 E-value: 7.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 4 YWSEakqLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDE 83
Cdd:PRK10189 27 FWRE---ITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 84 VRPAVHQGFWL-ALIVTPIAMVALYFSPLALQFM--DVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTM 160
Cdd:PRK10189 104 ARAAARQSLVImTLFAVLLAVLIHFFGEQIIDLVagDATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTKIPL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 161 VIGFVGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMI-VYVKCSAHFKRINLFAQLARPNGSRIWRLFR 239
Cdd:PRK10189 184 LINGGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIwVLMIGFNPALRISLKSYFKPLNFAIIWEVMG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 240 LGFPIAMaifcEVTLFTVVALM----LAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAAR 315
Cdd:PRK10189 264 IGIPASI----ESVLFNGGKLLtqmfVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAERQLR 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 316 TGLMLGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIVAYW 395
Cdd:PRK10189 340 HVFWLSTLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYAMWVSMLGMW 419
|
410 420
....*....|....*....|....*...
gi 657198907 396 GLGLPTGMILGltdwVVPRMGPQGFWIG 423
Cdd:PRK10189 420 GCRVVAGYILG----IMLGFGVVGVWMG 443
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
9-353 |
1.30e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 81.51 E-value: 1.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAV 88
Cdd:cd13144 8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 89 HQGFWLALIVT-PIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGL 167
Cdd:cd13144 88 NNGLLLALLSYlLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 168 AVNIPANYIFIHGHFGMPKLGGVGCGVATAI-VLWAMLLAMIVYVKCSahfKRINLFAQLARPNGSRIWRLFRLGFPIAM 246
Cdd:cd13144 168 IINIILDPILIFGLFGFPAMGIAGAAIATVIgQILAMFLAFFFLLRKN---KDVQPDLRLFRPSLRIIKEIYAVGLPSII 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 247 AIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAA 326
Cdd:cd13144 245 MQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVIML 324
|
330 340
....*....|....*....|....*..
gi 657198907 327 ATAALTVLLRDPIAGIYTDDLQVIGLA 353
Cdd:cd13144 325 AGGLLFQLFPDQLLGLFNASEEMLAIG 351
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
5-210 |
3.46e-16 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 80.19 E-value: 3.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 5 WSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEV 84
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 85 RPAVHQGFWLALIVTPIAMVALY-FSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIG 163
Cdd:COG0534 305 RRAARLALLLALGIGLLLALLLFlFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIIS 384
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 657198907 164 FVGL-AVNIPANYIFIHGHFGMpklggVGCGVATAIVLWAMLLAMIVY 210
Cdd:COG0534 385 LLRLwLVRLPLAYLLAFLGLGL-----TGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
9-212 |
5.63e-12 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 67.09 E-value: 5.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQ-VAQIAMnFVDTVMAGQVSAVDLAAVSVASSFW-LPIILLVQGIIMALTPIVSQLNGARKQDEVRP 86
Cdd:cd13123 215 RRVLKLMLPALLGVsVSQINL-LVDTILASFLPEGSISALYYADRLYqLPLGIFGVAIATALLPRLSRLAAAGDLDEFRR 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 87 AVHQGFWLALIVTPIAMVALYFspLALQFMDV-------DPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPT 159
Cdd:cd13123 294 TLSRGLRLVLFLLLPAAVGLIV--LAEPIVRLlfergafTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTP 371
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 657198907 160 MVIGFVGLAVNIPANYIFihghfgMPKLGGVGCGVATAIVLWAMLLAMIVYVK 212
Cdd:cd13123 372 VKIAVIAVAVNILLNLLL------IKPLGHVGLALATSLSAWVNALLLLVLLR 418
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-357 |
2.79e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 64.99 E-value: 2.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 11 LVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVAssfwLPIILLVQ-----GIIMALTPIVSQLNGARKQDEVR 85
Cdd:cd13148 14 LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALV----FPLLMLTQmmsngAMGGGVSSAIARALGAGDRERAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 86 PAVHQGFWLALIVTPIAMVA-LYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHT-MPTMVIg 163
Cdd:cd13148 90 ALVWHALVIALAGGLVFSLLfLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMrVPALVT- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 164 FVGLAVNIPANYIFIHGHFGMPKLGGVGCGVATAIVLWAMLLAMIVYvkCSAHFKRINLFAQLARPNGSRIWRLFRLGFP 243
Cdd:cd13148 169 LVGAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRY--LASGRSRLRLRLRALRLERRLFRDILRVGLL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 244 IAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMG 323
Cdd:cd13148 247 AALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARARRIAWTGALMAAV 326
|
330 340 350
....*....|....*....|....*....|....
gi 657198907 324 VAAATAALTVLLRDPIAGIYTDDLQVIGLAATLL 357
Cdd:cd13148 327 LAGAIGLVLALFPELWLGLFTHDPAVLAAGASYL 360
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
9-212 |
1.03e-10 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 63.63 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFW-LPIILLVQGIIMALTPIVSQLNGARKQDEVRPA 87
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYqLPLGLFGVAIGTALLPRLSRAAAAGDLEEFRRT 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 88 VHQGFWLALIVTPIAMVALYFspLALQFMDV-------DPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTM 160
Cdd:COG0728 302 LSRGLRLVLLLTLPAAVGLIV--LAEPIVRLlfergafTAEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPV 379
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 657198907 161 VIGFVGLAVNIPANYIFihghfgMPKLGGVGCGVATAIVLWAMLLAMIVYVK 212
Cdd:COG0728 380 RIAVIAVVVNIVLNLLL------VPPLGHAGLALATSLSALVNALLLLVLLR 425
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
5-209 |
2.62e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 59.06 E-value: 2.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 5 WSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEV 84
Cdd:cd13137 222 RKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEA 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 85 RPAVHQGFWLA-LIVTPIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIG 163
Cdd:cd13137 302 RRYGKRALRLGvLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIIN 381
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 657198907 164 FVGL-AVNIPANYIFIHgHFGMPKLGgvgcgvataiVLWAMLLAMIV 209
Cdd:cd13137 382 LISMwLVRLPLAYLLGF-VLGLGLTG----------IWLAMFVDTIV 417
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
230-393 |
3.45e-09 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 58.62 E-value: 3.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 230 NGSRIWRLFRLGFPIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQ 309
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 310 ARVAARTGLMLGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYV 389
Cdd:COG0534 83 ARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMII 162
|
....
gi 657198907 390 TIVA 393
Cdd:COG0534 163 MLIG 166
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
4-212 |
1.27e-08 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 56.78 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 4 YWSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQ-VSAVDLAAVSVASsfwlPIILLVQGIIMALT----PIVSQLNgA 78
Cdd:cd13128 201 DLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGYfLGDAAVGIYNAAY----RIAELLLFIPSAIStalfPRISELY-K 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 79 RKQDEVRPAVHQGF-WLALIVTPIAMVALYFSPLALQFmdvdpVMAAK---TAGYLHAILWGLPAFVMFQVLRNFSEGLS 154
Cdd:cd13128 276 NDKDELKKLLKKSFkYLFLISLPIAIGLFLFAEPIITL-----LFGEEylpAALVLQILAWGFLFIFLNGIFGSILQAIG 350
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 657198907 155 HTMPTMVIGFVGLAVNIPANYIFIhghfgmPKLGGVGCGVATAIVLWAMLLAMIVYVK 212
Cdd:cd13128 351 KQKLTLKILLIGALLNVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
9-362 |
2.08e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 56.01 E-value: 2.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 9 KQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAV 88
Cdd:cd13147 9 KAIIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 89 HQGFWLALIVTPIAMVALY-FSPLALQFMDVDPVmAAKTAGYLHAILWGLPAFVMFQV----LRnfSEGLSH-TMPTMVI 162
Cdd:cd13147 89 VHSILLGLIISIILTIVLLpFLEPILVLMGAGEV-LDLAVDYGRIIFLGSIFLIFNNVaygiLR--GEGDTKrAMYAMVA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 163 GFVglaVNIPANYIFIHGhFGMpklGGVGCGVAT--AIVLWAMLLAMIVYVKCSAHFKrinLFAQLARPNGSRIWRLFRL 240
Cdd:cd13147 166 GSI---LNIILDPIFIYT-LGL---GIAGAAWATviSMLISSLVLLYWFFVKKDTYVS---LSLKNFKFDKKIVKDILKV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 241 GFP-----IAMAIFceVTLFTVVALMLApfGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAAR 315
Cdd:cd13147 236 GIPasleqLIMSVL--MIILNLILVIVA--GTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYN 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 657198907 316 TGLMLGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAI 362
Cdd:cd13147 312 YSIKLGLIIELIIAILIFIFAPQIAYLFTYSEESAHLAPEIVAFLRI 358
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
11-208 |
1.76e-06 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 49.95 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 11 LVRLASPILVAQVAQIAMNFVDTVMAGQ-VSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEVRPAVH 89
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGAlLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 90 QGF-WLALIVTPIAMVALYFSPLALQFMDVDPVMAAktAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVGLA 168
Cdd:COG2244 255 KALrLLLLLGLPLALGLALLAPPLLSLLFGPEYAEA--APVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV 332
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 657198907 169 VNIPANYIFIhghfgmPKLGGVGCGVATAIVLWAMLLAMI 208
Cdd:COG2244 333 LNLVLNLLLI------PRYGLVGAAIATLLSYLVLLLLLL 366
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
5-110 |
2.60e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 49.17 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 5 WSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEV 84
Cdd:TIGR00797 212 WEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRA 291
|
90 100
....*....|....*....|....*.
gi 657198907 85 RPAVHQGFWLALIVTPIAMVALYFSP 110
Cdd:TIGR00797 292 KEVARVALKLSLLLGLVLAIILILFR 317
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-205 |
9.30e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 47.91 E-value: 9.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 5 WSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFWLPIILLVQGIIMALTPIVSQLNGARKQDEV 84
Cdd:cd13133 227 RELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLA 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 85 RPAVHQGFWLALIVTPIAMVALYFSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRN-FSEGLS---HTMPTM 160
Cdd:cd13133 307 MRVTRRGLKLALAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLLRFVAAYILFDALALvFAGALRgagDTRFVM 386
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 657198907 161 VIGFVGL-AVNIPANYIFIhgHFGMPKLGGVGCGVATAIVLWAMLL 205
Cdd:cd13133 387 LAELIVAwLYLLPPAYLLV--VLGAGLAGAWTVETVYVIVLALIFL 430
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-362 |
1.14e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 47.40 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 11 LVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVS-VASSFWLPIILLV--QGIIMALTPIVSQLNGARKQDEVRPA 87
Cdd:cd13146 10 LIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVGgIGLVFPLGMIFLAlgNGIQVGVSSLLARAIGAQRAKELDQA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 88 VHQGFWLALIVTPIAMVALY-FSPLALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGLSHTMPTMVIGFVG 166
Cdd:cd13146 90 ADSGLALALLAATVIVVLGYiFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 167 LAVNIPANYIFIHGhFGMpklGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLfaQLARPNGSRIWRLFRLGFPIAM 246
Cdd:cd13146 170 TVVNIVLDPILIFV-FDM---GVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHI--KLSNISSSVIVEILRVGLPQML 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 247 AIFCEVTLFTVVALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAARTGLMLGMGVAA 326
Cdd:cd13146 244 LQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVL 323
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 657198907 327 ATAALTVLLRDPIAGIYTDDLQVIGLA-------ATLLFFAAI 362
Cdd:cd13146 324 VLVLGYVLVAPWLFSLFTTVPEVVAYAvlqvrtmALALPFVAI 366
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
2-212 |
2.47e-04 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 43.23 E-value: 2.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 2 QRYWSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQVSAVDLAAVSVASSFW-------LPIILLVQGIIMALT----P 70
Cdd:cd13124 217 ISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRRLQAAGLSESEATALYgiltgraQPLVQLPTVIATALStslvP 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 71 IVSQLNGARKQDEVRPAVHQGFWLALIVTPIAMVALYFspLAlqfmdvDPVM-----AAKTAGYLHAILWGLPAFVMFQV 145
Cdd:cd13124 297 AISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAV--LA------EPINtllfgDSEGGLILQILAPSILFLSLQQV 368
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 657198907 146 LRNFSEGLSHTMPTMVIGFVGLAVNIPANYIFIhghfgmPKLGGVGCGVATAIVLWAMLLAMIVYVK 212
Cdd:cd13124 369 TAAILQGLGKVKIPVINLLIGLLVKIVLNYVLI------PIFGIYGAAIATVIGFLVAALLNLRALK 429
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
1-279 |
1.18e-03 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 41.26 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 1 MQRYWSEAKQLVRLASPILVAQVAQIAMNFVDTVMAGQV-SAVDLAAVSV---ASSFWLPIILLVQgiiMALTPIVSQLN 76
Cdd:PRK10367 1 MAFLTSSDKALWRLALPMIFSNITVPLLGLVDTAVIGHLdSPVYLGGVAVgatATSFLFMLLLFLR---MSTTGLTAQAF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 77 GARKQDEVRPAVHQGFWLALIVTpiAMVALYFSP---LALQFMDVDPVMAAKTAGYLHAILWGLPAFVMFQVLRNFSEGL 153
Cdd:PRK10367 78 GAKNPQALARALVQPLLLALGAG--ALIALLRTPlidLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 154 SHTMPTMVIGFVGLAVNIPANYIFIHGHfgmpKLGGVGCGVATAIVLWAMLLAMIVYVKCSAHFKRINLfAQLARPNGSR 233
Cdd:PRK10367 156 QYARAPVILLVVGNILNIVLDLWLVMGL----HMNVQGAALATVIAEYATLLIGLLMVRKVLKLRGISL-EMLKTAWRGN 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 657198907 234 IWRLFRLGFPIAMAIFCEVTLFTVVALMLAPFGAETVASHQIALNF 279
Cdd:PRK10367 231 FRRLLALNRDIMLRSLLLQLCFGAITVLGARLGSDIIAVNAVLMTL 276
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
237-440 |
7.37e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 38.75 E-value: 7.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 237 LFRLGFPIAMAIFCEvTLFTVV-ALMLAPFGAETVASHQIALNFSSLVFMLPLSIGVGVTIRVGHNIGEGQPDQARVAAR 315
Cdd:cd13144 10 LLTMSIPAMISMLFQ-ALYNIVdSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAAN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657198907 316 TGLMLGMGVAAATAALTVLLRDPIAGIYTDDLQVIGLAATLLFFAAIYQISDSVQVVAAAALRGYKDTQAIFYVTIV-AY 394
Cdd:cd13144 89 NGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIgAI 168
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 657198907 395 WGLGLPTGMILGLtdWVVPRMGPQGFWIGFIVGLTSAALMLGARLR 440
Cdd:cd13144 169 INIILDPILIFGL--FGFPAMGIAGAAIATVIGQILAMFLAFFFLL 212
|
|
| |
