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Conserved domains on  [gi|657627562|ref|WP_029438330|]
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MULTISPECIES: O-methyltransferase [Bacillus]

Protein Classification

O-methyltransferase( domain architecture ID 11467877)

O-methyltransferase of the class I-like SAM-binding methyltransferase superfamily, such as catechol O-methyltransferases that can use various catechol-like compounds

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.-.-
Gene Ontology:  GO:0008757|GO:0032259|GO:1904047|GO:0008168|GO:0008171
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 37-197 4.81e-52

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443298  Cd Length: 173  Bit Score: 164.97  E-value: 4.81e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  37 REMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEEtNGNVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAF 116
Cdd:COG4122    2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPD-DGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562 117 LDSQLDDSFDFIFLDSERTQYMWWLEHIKRILQPQGLLVVDNATSH------------ASELVEFIKMIEEDEMFETVLL 184
Cdd:COG4122   81 LPRLADGPFDLVFIDADKSNYPDYLELALPLLRPGGLIVADNVLWHgrvadparrdpsTRAIREFNEYLREDPRLESVLL 160

                        170
                 ....*....|...
gi 657627562 185 AFQNGAFVARKKK 197
Cdd:COG4122  161 PIGDGLLLARKRG 173
 
Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 37-197 4.81e-52

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 164.97  E-value: 4.81e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  37 REMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEEtNGNVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAF 116
Cdd:COG4122    2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPD-DGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562 117 LDSQLDDSFDFIFLDSERTQYMWWLEHIKRILQPQGLLVVDNATSH------------ASELVEFIKMIEEDEMFETVLL 184
Cdd:COG4122   81 LPRLADGPFDLVFIDADKSNYPDYLELALPLLRPGGLIVADNVLWHgrvadparrdpsTRAIREFNEYLREDPRLESVLL 160

                        170
                 ....*....|...
gi 657627562 185 AFQNGAFVARKKK 197
Cdd:COG4122  161 PIGDGLLLARKRG 173
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 15-196 5.06e-27

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 101.81  E-value: 5.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   15 EQYGEEHDRNKKTREEKLRN------ISREMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEEtNGNVTTVELSSE 88
Cdd:pfam01596   1 ETSAYEHEYLKELREETAKLplapmqVSPDEGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPE-DGKITAIDIDPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   89 RVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDDS----FDFIFLDSERTQYMWWLEHIKRILQPQGLLVVDNATSHAS 164
Cdd:pfam01596  80 AYEIAKKFIQKAGVAHKISFILGPALKVLEQLTQDKplpeFDFIFIDADKSNYPNYYERLLELLKVGGLMAIDNTLWHGK 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 657627562  165 ------------ELVEFIKMIEEDEMFETVLLAFQNGAFVARKK 196
Cdd:pfam01596 160 vtepddqeaktqRLQEFNKDLAQDPRVEISVIPVGDGITLCRKI 203
PLN02589 PLN02589
caffeoyl-CoA O-methyltransferase
 5-164 2.74e-17

caffeoyl-CoA O-methyltransferase


Pssm-ID: 166230  Cd Length: 247  Bit Score: 76.96  E-value: 2.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   5 DTLDSLLFQLEQYGEEHDRNKKTREEKLR---NI---SREMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEEtNG 78
Cdd:PLN02589  27 DALYQYILETSVYPREPESMKELRELTAKhpwNImttSADEGQFLNMLLKLINAKNTMEIGVYTGYSLLATALALPE-DG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  79 NVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDD-----SFDFIFLDSERTQYMWWLEHIKRILQPQGL 153
Cdd:PLN02589 106 KILAMDINRENYELGLPVIQKAGVAHKIDFREGPALPVLDQMIEDgkyhgTFDFIFVDADKDNYINYHKRLIDLVKVGGV 185

                        170
                 ....*....|.
gi 657627562 154 LVVDNATSHAS 164
Cdd:PLN02589 186 IGYDNTLWNGS 196
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 54-156 3.09e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  54 NILEIGTSNGYSTLWLANAVeetNGNVTTVELSSERVGEALANfEKANLLQRIDVHNQEAGAFLDsQLDDSFDFIFLDSE 133
Cdd:cd02440    1 RVLDLGCGTGALALALASGP---GARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPP-EADESFDVIISDPP 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 657627562 134 rtqYMWWLEHIKRILQ-------PQGLLVV 156
Cdd:cd02440   76 ---LHHLVEDLARFLEearrllkPGGVLVL 102
 
Name Accession Description Interval E-value
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 37-197 4.81e-52

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 164.97  E-value: 4.81e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  37 REMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEEtNGNVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAF 116
Cdd:COG4122    2 PEQGRLLYLLARLLGAKRILEIGTGTGYSTLWLARALPD-DGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562 117 LDSQLDDSFDFIFLDSERTQYMWWLEHIKRILQPQGLLVVDNATSH------------ASELVEFIKMIEEDEMFETVLL 184
Cdd:COG4122   81 LPRLADGPFDLVFIDADKSNYPDYLELALPLLRPGGLIVADNVLWHgrvadparrdpsTRAIREFNEYLREDPRLESVLL 160

                        170
                 ....*....|...
gi 657627562 185 AFQNGAFVARKKK 197
Cdd:COG4122  161 PIGDGLLLARKRG 173
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 15-196 5.06e-27

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 101.81  E-value: 5.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   15 EQYGEEHDRNKKTREEKLRN------ISREMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEEtNGNVTTVELSSE 88
Cdd:pfam01596   1 ETSAYEHEYLKELREETAKLplapmqVSPDEGQFLGMLVKLTGAKNVLEIGVFTGYSALAMALALPE-DGKITAIDIDPE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   89 RVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDDS----FDFIFLDSERTQYMWWLEHIKRILQPQGLLVVDNATSHAS 164
Cdd:pfam01596  80 AYEIAKKFIQKAGVAHKISFILGPALKVLEQLTQDKplpeFDFIFIDADKSNYPNYYERLLELLKVGGLMAIDNTLWHGK 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 657627562  165 ------------ELVEFIKMIEEDEMFETVLLAFQNGAFVARKK 196
Cdd:pfam01596 160 vtepddqeaktqRLQEFNKDLAQDPRVEISVIPVGDGITLCRKI 203
PLN02589 PLN02589
caffeoyl-CoA O-methyltransferase
 5-164 2.74e-17

caffeoyl-CoA O-methyltransferase


Pssm-ID: 166230  Cd Length: 247  Bit Score: 76.96  E-value: 2.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   5 DTLDSLLFQLEQYGEEHDRNKKTREEKLR---NI---SREMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEEtNG 78
Cdd:PLN02589  27 DALYQYILETSVYPREPESMKELRELTAKhpwNImttSADEGQFLNMLLKLINAKNTMEIGVYTGYSLLATALALPE-DG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  79 NVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDD-----SFDFIFLDSERTQYMWWLEHIKRILQPQGL 153
Cdd:PLN02589 106 KILAMDINRENYELGLPVIQKAGVAHKIDFREGPALPVLDQMIEDgkyhgTFDFIFVDADKDNYINYHKRLIDLVKVGGV 185

                        170
                 ....*....|.
gi 657627562 154 LVVDNATSHAS 164
Cdd:PLN02589 186 IGYDNTLWNGS 196
PLN02781 PLN02781
Probable caffeoyl-CoA O-methyltransferase
 5-158 9.60e-17

Probable caffeoyl-CoA O-methyltransferase


Pssm-ID: 215417  Cd Length: 234  Bit Score: 75.24  E-value: 9.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   5 DTLDSLLFQLEQYGEEHDRNKKTRE---EKLRNISrEM------GQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEE 75
Cdd:PLN02781  14 EALKQYIMETSAYPREHELLKELREatvQKYGNLS-EMevpvdeGLFLSMLVKIMNAKNTLEIGVFTGYSLLTTALALPE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  76 tNGNVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDDS----FDFIFLDSERTQYMWWLEHIKRILQPQ 151
Cdd:PLN02781  93 -DGRITAIDIDKEAYEVGLEFIKKAGVDHKINFIQSDALSALDQLLNNDpkpeFDFAFVDADKPNYVHFHEQLLKLVKVG 171


                 ....*..
gi 657627562 152 GLLVVDN 158
Cdd:PLN02781 172 GIIAFDN 178
Methyltransf_24 pfam13578
Methyltransferase domain; This family appears to be a methyltransferase domain.
 56-158 1.71e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 433324 [Multi-domain]  Cd Length: 106  Bit Score: 71.57  E-value: 1.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   56 LEIGTSNGYSTLWLANAVEETN-GNVTTVELsSERVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDDSFDFIFLDS-- 132
Cdd:pfam13578   1 VEIGTYSGVSTLWLAAALRDNGlGRLTAVDP-DPGAEEAGALLRKAGLDDRVRLIVGDSREALPSLADGPIDLLFIDGdh 79

                          90       100
                  ....*....|....*....|....*.
gi 657627562  133 ERTQYMWWLEHIKRILQPQGLLVVDN 158
Cdd:pfam13578  80 TYEAVLNDLELWLPRLAPGGVILFHD 105
PLN02476 PLN02476
O-methyltransferase
 25-196 1.31e-13

O-methyltransferase


Pssm-ID: 178094  Cd Length: 278  Bit Score: 67.39  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  25 KKTREE--KLR----NISREMGQFLSILVKGCSAKNILEIGTSNGYSTLWLANAVEETnGNVTTVELSSERVGEALANFE 98
Cdd:PLN02476  86 RQLREEtsKMRgsqmQVSPDQAQLLAMLVQILGAERCIEVGVYTGYSSLAVALVLPES-GCLVACERDSNSLEVAKRYYE 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  99 KANLLQRIDVHNQEAGAFLDSQLDD----SFDFIFLDSERTQYMWWLEHIKRILQPQGLLVVDNATSH---ASELV---- 167
Cdd:PLN02476 165 LAGVSHKVNVKHGLAAESLKSMIQNgegsSYDFAFVDADKRMYQDYFELLLQLVRVGGVIVMDNVLWHgrvADPLVndak 244

                        170       180       190
                 ....*....|....*....|....*....|....
gi 657627562 168 -----EFIKMIEEDEMFETVLLAFQNGAFVARKK 196
Cdd:PLN02476 245 tisirNFNKKLMDDKRVSISMVPIGDGMTICRKR 278
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 53-183 3.15e-11

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 60.56  E-value: 3.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  53 KNILEIGTSNGYSTLWLANAVEETnGNVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAFLDsqlDDSFDFIFLDs 132
Cdd:COG2519   93 ARVLEAGTGSGALTLALARAVGPE-GKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGID---EGDVDAVFLD- 167

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 657627562 133 ertqyM---W-WLEHIKRILQPQGLLVVDNAT-SHASELVE------FIkmieEDEMFETVL 183
Cdd:COG2519  168 -----MpdpWeALEAVAKALKPGGVLVAYVPTvNQVSKLVEalresgFT----DIEAVETLL 220
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 54-168 7.72e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 56.08  E-value: 7.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  54 NILEIGTSNGYSTLWLANAveeTNGNVTTVELSSERVGEALANFEKANlLQRIDVHNQEAGAFLDSQlDDSFDFIFLD-- 131
Cdd:COG0500   29 RVLDLGCGTGRNLLALAAR---FGGRVIGIDLSPEAIALARARAAKAG-LGNVEFLVADLAELDPLP-AESFDLVVAFgv 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 657627562 132 ------SERTQYmwwLEHIKRILQPQGLLVVDNATSHASELVE 168
Cdd:COG0500  104 lhhlppEEREAL---LRELARALKPGGVLLLSASDAAAALSLA 143
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 55-152 1.04e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 53.34  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   55 ILEIGTSNGYSTLWLANAVeetNGNVTTVELSSERVGEALANFEKANLlqRIDVHNQEAGAFldSQLDDSFDFIFLdSER 134
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG---GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDL--PFPDGSFDLVVS-SGV 72

                          90       100
                  ....*....|....*....|....
gi 657627562  135 TQYMWW------LEHIKRILQPQG 152
Cdd:pfam13649  73 LHHLPDpdleaaLREIARVLKPGG 96
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 55-156 3.26e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.39  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  55 ILEIGTSNGYSTLWLAnavEETNGNVTTVELSSERVGEALANFEKANLLQRIDVHNQEagaFLDSQLDDSFDFIFL---- 130
Cdd:COG2230   55 VLDIGCGWGGLALYLA---RRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLAD---YRDLPADGQFDAIVSigmf 128

                         90       100       110
                 ....*....|....*....|....*....|
gi 657627562 131 ----DSERTQYmwwLEHIKRILQPQGLLVV 156
Cdd:COG2230  129 ehvgPENYPAY---FAKVARLLKPGGRLLL 155
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 53-171 7.67e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 52.30  E-value: 7.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  53 KNILEIGTSNGYSTLWLAnaveETNGNVTTVELSSERVGEALANFEKANLlqRIDVHNQEAGAF-LDsqlDDSFDFIFL- 130
Cdd:COG2226   24 ARVLDLGCGTGRLALALA----ERGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLpFP---DGSFDLVISs 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 657627562 131 -------DSERTqymwwLEHIKRILQPQG-LLVVDNATSHASELVEFIK 171
Cdd:COG2226   95 fvlhhlpDPERA-----LAEIARVLKPGGrLVVVDFSPPDLAELEELLA 138
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 54-156 3.09e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 3.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  54 NILEIGTSNGYSTLWLANAVeetNGNVTTVELSSERVGEALANfEKANLLQRIDVHNQEAGAFLDsQLDDSFDFIFLDSE 133
Cdd:cd02440    1 RVLDLGCGTGALALALASGP---GARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPP-EADESFDVIISDPP 75

                         90       100       110
                 ....*....|....*....|....*....|
gi 657627562 134 rtqYMWWLEHIKRILQ-------PQGLLVV 156
Cdd:cd02440   76 ---LHHLVEDLARFLEearrllkPGGVLVL 102
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 53-156 5.21e-07

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 46.93  E-value: 5.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  53 KNILEIGTSNGYSTLWLANAVEEtngnVTTVELSSERVGEALANFEKANllqrIDVHNQEAGAFldSQLDDSFDFIFL-- 130
Cdd:COG2227   26 GRVLDVGCGTGRLALALARRGAD----VTGVDISPEALEIARERAAELN----VDFVQGDLEDL--PLEDGSFDLVICse 95

                         90       100       110
                 ....*....|....*....|....*....|..
gi 657627562 131 ------DSERtqymwWLEHIKRILQPQGLLVV 156
Cdd:COG2227   96 vlehlpDPAA-----LLRELARLLKPGGLLLL 122
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 56-156 1.06e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 42.27  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   56 LEIGTSNGYSTLWLAnaveETNGNVTTVELSSERVGEALANFEKANLLQRIdvhnqeaGAFLDSQL-DDSFDFIFLdser 134
Cdd:pfam08241   1 LDVGCGTGLLTELLA----RLGARVTGVDISPEMLELAREKAPREGLTFVV-------GDAEDLPFpDNSFDLVLS---- 65

                          90       100       110
                  ....*....|....*....|....*....|..
gi 657627562  135 tqyMWWLEH----------IKRILQPQGLLVV 156
Cdd:pfam08241  66 ---SEVLHHvedperalreIARVLKPGGILII 94
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 51-175 4.21e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 42.82  E-value: 4.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  51 SAKNILEIGTSNGYSTLWLANAVEetNGNVTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDDSFDFIF- 129
Cdd:COG4123   37 KGGRVLDLGTGTGVIALMLAQRSP--GARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAAELPPGSFDLVVs 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 657627562 130 -------------LDSERTQYMW--------WLEHIKRILQPQGLLVVdnaTSHASELVEFIKMIEE 175
Cdd:COG4123  115 nppyfkagsgrksPDEARAIARHedaltledLIRAAARLLKPGGRFAL---IHPAERLAEILAALRK 178
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 51-177 4.49e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.02  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562   51 SAKNILEIGTSNGYSTLWLANAVEEtNGNVTTVELSSERVGEALANFEKaNLLQRIDVHNQEAGAFLDSQLDDSFDFIFL 130
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGP-NAEVVGIDISEEAIEKARENAQK-LGFDNVEFEQGDIEELPELLEDDKFDVVIS 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 657627562  131 --------DSERTqymwwLEHIKRILQPQGLLVVdnatSHASELVEFIKMIEEDE 177
Cdd:pfam13847  81 ncvlnhipDPDKV-----LQEILRVLKPGGRLII----SDPDSLAELPAHVKEDS 126
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 80-156 1.78e-04

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 40.45  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657627562  80 VTTVELSSERVGEALANFEKANLLQRIDVHNQEAGAFLDSQLDDSFDFIFLD-------SERTqymwwLEHI--KRILQP 150
Cdd:COG0742   67 VVFVEKDRKAAAVIRKNLEKLGLEDRARVIRGDALRFLKRLAGEPFDLVFLDppyakglLEKA-----LELLaeNGLLAP 141


                 ....*.
gi 657627562 151 QGLLVV 156
Cdd:COG0742  142 GGLIVV 147
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 54-104 2.19e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 37.69  E-value: 2.19e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 657627562  54 NILEIGTSNGYSTLWLANAVEETnGNVTTVelssERVGEaLANFEKANLLQ 104
Cdd:PRK13942  79 KVLEIGTGSGYHAAVVAEIVGKS-GKVVTI----ERIPE-LAEKAKKTLKK 123
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
54-102 3.49e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 37.11  E-value: 3.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 657627562  54 NILEIGTSNGYSTLWLANAVEEtngnVTTVELSSERVGEALANFEKANL 102
Cdd:PRK00312  81 RVLEIGTGSGYQAAVLAHLVRR----VFSVERIKTLQWEAKRRLKQLGL 125
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 55-102 7.67e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 35.83  E-value: 7.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 657627562  55 ILEIGTSNGYSTLWLANAVeetnGNVTTVELSSERVGEALANFEKANL 102
Cdd:COG2518   70 VLEIGTGSGYQAAVLARLA----GRVYSVERDPELAERARERLAALGY 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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